Title: M1846 Postprandial Reflux Patterns in Healthy Volunteers (HV) and Patients with Gastro-Esophageal Refux Disease (GERD)
Abstract: Introduction:Acid reflux has been shown to be able to induce microscopic esophagitis in non-erosive reflux disease (NERD) patients.There are no data on the role of nonacid reflux in causing the same histological alteration.Aim: To assess whether nonacid reflux can provoke microscopic esophagitis in NERD patients.Methods: We evaluated 35 consecutive patients with NERD (20F, median age 47; range 40-71 yrs) while off-PPI therapy.During the upper GI endoscopy multiple biopsies were taken at the Z-line, 2 and 4 cm above it.Microscopic esophagitis was identified by necrosis/erosion, neutrophil/eosinophil intraepithelial infiltration, basal cell hyperplasia, elongation of papillae, dilation of intercellular spaces and a score (range: 0-2) was given for each lesion.In agreement with previous studies a cut-off value of 2 was considered for diagnosing a microscopic esophagitis 1 .Within 3 days of endoscopy, patients underwent a multichannel intraluminal impedance and pH (MII-pH) testing using a standardized Mediterranean diet.We measured distal esophageal acid exposure time (AET) and number of impedance-detected reflux episodes (acid, nonacid) 2 .Results: Out of 35 NERD patients, 15 (43%) had an abnormal esophageal AET.Among these, 10 (29%) patients had microscopic esophagitis in agreement with our histological score (score>2).The remaining twenty (57%) patients had normal distal esophageal AET,
Publication Year: 2009
Publication Date: 2009-05-01
Language: en
Type: article
Indexed In: ['crossref']
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