Cyclin D3 Expression in Melanoma Cells Is Regulated by Adhesion-dependent Phosphatidylinositol 3-Kinase Signaling and Contributes to G1-S Progression

Name: Work Video:
Duration: 3 min 30 s
Laurie S. Spofford; Ethan V. Abel; Karen Boisvert-Adamo; Andrew E. Aplin
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4120, 4235, 4261, 4279, 4311, 4357, 4368, 4401, 4411, 4430, 4442, 4452, 4480, 4518, 4532, 4640, 4658, 4678, 4701, 4706, 4763, 4900, 4902, 4994, 5372, 5416, 5500, 5560, 5595, 5763, 5799, 5870, 5977, 5989], 'their': [16, 184, 657, 4282, 4424, 4460], 'expression': [17, 62, 185, 230, 408, 1254, 2431, 2532, 2546, 2553, 2738, 2976, 3288, 3506, 3612, 3653, 3821, 3896, 3938, 3955, 3997, 4363, 4380, 4569, 4574, 4590, 4651, 4669, 4715, 4940, 4989, 5491], 'is': [18, 33, 126, 148, 186, 201, 294, 316, 656, 808, 820, 845, 880, 903, 925, 935, 1255, 1265, 1291, 1308, 1357, 1366, 2432, 2536, 2980, 3393, 3736, 3780, 4127, 4208, 4384, 4652, 4659, 4670, 4687, 4883, 5201, 5383, 5405, 5492, 5507, 5586, 5842, 5862], 'frequently': [19, 187, 686, 2537, 3394], 'altered': [20, 188, 697, 3222, 3395], 'in': [21, 35, 56, 65, 104, 165, 189, 203, 224, 233, 272, 333, 404, 431, 475, 561, 688, 712, 839, 893, 937, 1205, 1258, 1293, 1334, 1348, 1360, 1447, 1479, 1563, 1755, 1856, 1894, 1945, 2019, 2073, 2097, 2198, 2267, 2330, 2422, 2434, 2486, 2515, 2539, 2739, 2955, 2977, 3060, 3071, 3079, 3115, 3227, 3294, 3345, 3357, 3364, 3396, 3498, 3534, 3542, 3554, 3571, 3595, 3700, 3717, 3750, 3778, 3793, 3832, 3848, 3941, 3965, 3983, 3998, 4016, 4036, 4128, 4136, 4179, 4281, 4288, 4331, 4345, 4360, 4364, 4419, 4477, 4483, 4506, 4540, 4609, 4654, 4680, 4691, 4716, 4775, 4886, 4919, 5013, 5024, 5054, 5212, 5224, 5341, 5365, 5436, 5508, 5569, 5742, 5796, 5852], 'malignant': [22, 190, 654], 'cells.': [23, 59, 106, 167, 191, 227, 274, 335, 1351, 3296, 3536, 3719, 4074, 4542, 4693, 5056, 5571], 'We': [24, 192, 1352, 3339, 3783, 4240, 5486, 5937, 5959], 'others': [26, 194, 3325, 5733], 'have': [27, 195, 477, 3106, 3730, 4707, 5059, 5380, 5734], 'previously': [28, 196, 1410, 1636, 2971, 3731, 4172], 'shown': [29, 197, 3107, 5219], 'that': [30, 93, 124, 145, 159, 198, 261, 292, 313, 327, 1354, 1750, 1830, 2442, 2531, 2973, 3024, 3108, 3309, 3351, 3386, 3733, 3903, 3923, 3993, 4058, 4110, 4209, 4324, 4332, 4377, 4446, 4494, 4529, 4648, 4698, 4769, 4880, 4892, 4926, 5017, 5198, 5488, 5541, 5557, 5723, 5844, 5859, 5923], 'cyclin': [31, 54, 94, 109, 117, 132, 139, 146, 199, 222, 262, 277, 285, 300, 307, 314, 557, 604, 933, 1213, 1250, 1252, 1332, 1355, 1389, 1396, 1622, 1629, 1678, 1697, 1711, 1956, 1981, 1997, 2140, 2355, 2429, 2481, 2534, 2974, 3010, 3058, 3113, 3290, 3321, 3559, 3575, 3599, 3610, 3642, 3651, 3664, 3714, 3734, 3776, 3791, 3816, 3851, 3857, 3870, 3881, 3898, 3907, 3936, 3953, 3971, 3974, 3995, 4021, 4039, 4051, 4062, 4081, 4111, 4125, 4134, 4177, 4213, 4233, 4238, 4255, 4277, 4295, 4319, 4327, 4351, 4361, 4369, 4382, 4392, 4396, 4409, 4412, 4450, 4453, 4469, 4473, 4499, 4507, 4516, 4524, 4530, 4533, 4544, 4548, 4588, 4613, 4638, 4649, 4667, 4685, 4713, 4770, 4881, 4912, 4931, 4947, 5011, 5021, 5199, 5222, 5338, 5402, 5433, 5489, 5515, 5544, 5549, 5558, 5561, 5578, 5596, 5715, 5739, 5845, 5860, 5928, 5986], 'D1': [32, 110, 200, 278, 934, 1214, 1698, 1712, 1779, 1812, 1957, 2356, 2975, 3652, 3665, 3735, 3858, 4135, 4160, 4178, 4234, 4278, 4296, 4328, 4383, 4400, 4413, 4454, 4470, 4478, 4517, 4534, 4549, 4686, 4702, 5012, 5022, 5403, 5516, 5545, 5562, 5579, 5987], 'up-regulated': [34, 202], 'melanoma': [36, 58, 71, 105, 153, 166, 204, 226, 239, 273, 321, 334, 807, 921, 941, 1262, 1335, 1350, 1361, 1527, 1558, 2439, 2449, 2541, 2740, 2978, 3228, 3295, 3311, 3397, 3718, 3779, 3796, 3944, 4000, 4115, 4180, 4249, 4420, 4541, 4656, 4681, 4718, 4888, 4920, 4923, 5014, 5055, 5069, 5329, 5367, 5503, 5570, 5867, 5935, 5979], 'cells': [37, 205, 496, 500, 655, 838, 1362, 1546, 1588, 1850, 2062, 2144, 2171, 2264, 2317, 2507, 2559, 2979, 3019, 3031, 3050, 3063, 3074, 3247, 3278, 3369, 3502, 3544, 3581, 3619, 3632, 3702, 3752, 3797, 3834, 3837, 3967, 4001, 4042, 4066, 4087, 4138, 4250, 4260, 4263, 4290, 4371, 4562, 4657, 4682, 4891, 5015, 5330, 5343, 5359, 5368, 5439, 5745], 'through': [38, 206, 1017, 3807], 'adhesion-independent': [39, 207, 5026], 'MEK-ERK1/2': [40, 208, 5018], 'signaling': [41, 84, 209, 252, 700, 1020, 3111, 3286, 3390, 3570, 3712, 5019, 5211, 5216], 'initiated': [42, 210], 'mutant': [44, 212, 3337, 3794], 'B-RAF.': [45, 213, 3338], 'Here,': [46, 214], 'we': [47, 215, 1338, 1734, 3016, 3230, 3527, 3578, 3934, 4028, 4230, 4422, 4553, 4646, 4878], 'describe': [48, 216], 'regulation': [50, 218, 1307, 1341, 1383, 3573, 5004], 'role': [52, 220, 1330, 3519, 3566, 4132, 4953, 5851], 'D3': [55, 61, 95, 118, 147, 223, 229, 263, 286, 315, 1253, 1290, 1333, 1356, 1390, 1630, 1679, 1998, 2141, 2352, 2419, 2430, 2482, 2511, 2535, 2737, 2758, 2960, 3011, 3059, 3114, 3291, 3302, 3322, 3560, 3576, 3600, 3611, 3643, 3715, 3721, 3777, 3792, 3820, 3852, 3882, 3908, 3937, 3949, 3972, 3996, 4009, 4022, 4040, 4052, 4063, 4082, 4112, 4126, 4166, 4214, 4352, 4393, 4403, 4410, 4451, 4474, 4484, 4508, 4531, 4545, 4614, 4639, 4650, 4668, 4700, 4714, 4771, 4882, 4913, 4932, 4988, 5200, 5223, 5339, 5352, 5434, 5490, 5550, 5559, 5573, 5670, 5716, 5861], 'human': [57, 70, 225, 238, 372, 689, 1349, 1400, 1696, 2438, 2540, 3999, 4254, 4655, 4717], 'Cyclin': [60, 228, 485, 1289, 2351, 2418, 2510, 2959, 3301, 3720, 3819, 3948, 4008, 4159, 4165, 4170, 4399, 4402, 4987, 5572], 'was': [63, 78, 231, 246, 1458, 1633, 1682, 1691, 1700, 1714, 1780, 1799, 1837, 2048, 2156, 2222, 2288, 2374, 2483, 2512, 3012, 3272, 3354, 3551, 3590, 3822, 3963, 4047, 4312, 4329, 4343, 4475, 4513, 4990, 5354, 5361, 5729], 'enhanced': [64, 232, 936, 2538, 3055, 3255, 3273, 4379, 4505, 4616, 4653, 4930, 5673], 'a': [66, 127, 234, 295, 814, 928, 1268, 1294, 1369, 1604, 1617, 1701, 1747, 2053, 2129, 2162, 2225, 2302, 2325, 2435, 2956, 3022, 3383, 3584, 3593, 3635, 3840, 3884, 3942, 4131, 4174, 4217, 4220, 4242, 4520, 4951, 5205, 5511, 5712], 'panel': [68, 236, 2436], 'lines': [73, 241, 1533, 1560, 2441, 2491, 2750, 2780, 3313, 3335, 3348, 4285, 4720, 4889, 4925, 5369], 'compared': [74, 242, 1301, 1363, 1394, 3323, 3835, 3968, 4069], 'with': [75, 138, 243, 306, 813, 905, 927, 1267, 1302, 1364, 1395, 1449, 1460, 1594, 1746, 1764, 1782, 1810, 1827, 1867, 1879, 1917, 1935, 2024, 2068, 2174, 2180, 2209, 2224, 2243, 2275, 2320, 2366, 2402, 2408, 2551, 3324, 3504, 3548, 3582, 3592, 3620, 3633, 3668, 3829, 3836, 3839, 3883, 3969, 4070, 4076, 4251, 4271, 4336, 4459, 4498, 4515, 4523, 4538, 4618, 5006, 5331, 5581, 5588, 5727, 5872, 6003], 'melanocytes': [76, 244, 1402, 3366], 'regulated': [79, 164, 247, 332, 346, 1367, 3013, 4660, 4705, 4991, 5053], 'fibronectin-mediated': [81, 249], 'phosphatidylinositol': [82, 250, 377], '3-kinase/Akt': [83, 251], 'but': [85, 253, 1300, 2273, 3044, 3250, 3361, 3645, 3709, 3860, 4286, 4471, 4546, 4997, 5360], 'not': [86, 112, 254, 280, 2548, 3076, 3251, 3704, 3710, 3781, 3855, 3916, 3927, 4287, 4385, 4472, 4547, 4585, 4904, 4928, 4999, 5345, 5547, 5704, 5730], 'MEK': [87, 255, 3636, 3711, 5001], 'activity.': [88, 256, 5002], 'RNA': [89, 257, 389, 1583, 1598], 'interference': [90, 258], 'experiments': [91, 259, 4322, 5364], 'demonstrated': [92, 260, 4173, 4445], 'contributed': [96, 264], 'to': [97, 265, 406, 693, 707, 908, 922, 1209, 1249, 1344, 1377, 1462, 1721, 1757, 1793, 1823, 2158, 2234, 2412, 2969, 3029, 3039, 3062, 3220, 3248, 3253, 3279, 3391, 3530, 3786, 3918, 3929, 3985, 4003, 4011, 4024, 4114, 4130, 4246, 4303, 4317, 4354, 4387, 4416, 4426, 4519, 4551, 4556, 4765, 5203, 5220, 5376, 5394, 5510, 5675, 5711, 5717, 5803, 5932, 5940, 5963], 'G1-S': [98, 154, 266, 322, 659, 4674], 'proliferation': [103, 271, 493, 664, 4092, 4679, 5501, 5869], 'Overexpression': [107, 275, 4161], 'did': [111, 279, 3075, 3854, 4584, 4998, 5703], 'recover': [113, 281], 'effects': [115, 283, 3605, 3660, 3801, 3890, 3905, 4211, 4390, 4632], 'knockdown.': [119, 287, 4642], 'Finally,': [120, 288], 'immunoprecipitation': [121, 289, 4444, 4458], 'studies': [122, 290, 474, 1260, 4723, 5058, 5874], 'showed': [123, 291, 2972, 3054, 3308, 4057, 4323, 4493, 4615], 'CDK6': [125, 293, 401, 1965, 4502, 4565, 4571, 4583, 4610, 4641, 5702, 5800], 'major': [128, 296, 5206], 'binding': [129, 297, 1386, 4342, 4425, 4491, 4710], 'partner': [130, 298, 5726], 'for': [131, 299, 482, 1524, 1591, 1731, 1839, 1853, 1885, 1929, 2032, 2113, 2149, 2183, 2195, 2214, 2255, 2296, 2392, 3086, 3233, 3725, 3741, 4090, 4124, 4176, 4219, 4672, 5062, 5208, 5348, 5494, 5514, 5951, 5956, 5971, 5985, 5993], 'D3,': [133, 301, 1623], 'whereas': [134, 302, 4501, 5577], 'CDK4': [135, 303, 399, 1952, 4337, 4341, 4495, 4576, 5798], 'preferentially': [136, 304, 4496, 5574], 'associated': [137, 305, 904, 926, 1266, 3591, 4497, 4514], 'D1.': [140, 308, 1397, 1796, 4256, 4320], 'Together,': [141, 309, 3989], 'these': [142, 310, 3080, 3333, 3346, 3659, 3695, 3990, 4077, 4137, 4692], 'findings': [143, 311, 2529, 3304, 4527, 5009, 5555], 'demonstrate': [144, 312, 4109, 4697], 'an': [149, 317, 809, 1450, 2291, 3239, 3552, 3825, 4355, 4916, 5025, 5349, 5384, 5849, 5863], 'important': [150, 318, 1392, 5385, 5850, 5864], 'regulator': [151, 319, 5865], 'are': [162, 330, 345, 402, 429, 685, 1774, 2751, 2781, 3292, 3666, 3915, 4703, 4773, 5051, 5801, 5938, 5960], 'differentially': [163, 331, 4704, 5052], 'entry': [341, 454, 2138, 3749, 4119, 5496], 'into': [342, 455, 1716, 1770, 5497], 'S': [343, 456, 3747, 4025, 4117, 5498], 'phase': [344, 457, 879, 902, 3748, 4026, 4118, 4898, 5499], '(CDKs).': [353], '2The': [354], 'abbreviations': [355], 'used': [356, 1523, 1690, 1735, 1838, 1944, 2127], 'are:': [357], 'CDK,': [358], 'kinase;': [360, 364, 369], 'ERK,': [361], 'extracellular': [362], 'signal-regulated': [363], 'MEK,': [365], 'mitogen-activated': [366], 'protein': [367, 2386], 'kinase/ERK': [368], 'NHEM,': [370], 'normal': [371, 3365], 'epidermal': [373, 1401, 1473], 'melanocytes;': [374], 'PI-3': [375, 1372, 3109, 3224, 3284, 3297, 3388, 3568, 3585, 3707, 4663, 4995, 5064, 5209, 5214], 'kinase,': [376], '3-kinase;': [378], 'PTEN,': [379, 1971], 'phosphatase': [380, 3374, 3385], 'tensin': [382, 3376], 'homologue': [383, 3377], 'deleted': [384, 3378], 'from': [385, 831, 1406, 1439, 1466, 1472, 1516, 1536, 1703, 1960, 1973, 1990, 2000, 2005, 2012, 2525, 2752, 2782, 3305, 3379, 5357], 'chromosome': [386, 3380], '10;': [387], 'RNAi,': [388], 'interference;': [390], 'siRNA,': [391], 'short-interfering': [392, 1597], 'RNA;': [393], 'BrdUrd,': [394, 4035], 'bromodeoxyuridine.': [395], 'In': [396, 1247, 1434, 3627, 4560, 4643, 4922, 5323, 5854], 'early': [397, 825, 4917], 'activated': [403], 'response': [405], 'increased': [407, 2433, 3994, 4774], '(1Sherr': [412], 'C.J.': [413, 1118, 2664, 2881], 'Roberts': [414], 'J.M.': [415, 949, 1278, 3399, 4735, 5073, 5168], 'Genes': [416, 462, 545], 'Dev.': [417, 463, 546], '1999;': [418, 4849, 5912], '13:': [419], '1501-1512Crossref': [420], 'PubMed': [421, 467, 530, 550, 598, 645, 678, 748, 787, 872, 1012, 1129, 1151, 1179, 1323, 1429, 1672, 2472, 2675, 2731, 2892, 2948, 3141, 3209, 4758, 4814, 4831, 4852, 4872, 5124, 5141, 5190, 5245, 5318, 5428, 5481, 5633, 5663, 5695, 5758, 5786, 5835, 5915], 'Scopus': [422, 468, 531, 551, 599, 646, 679, 749, 788, 873, 1013, 1130, 1152, 1180, 1200, 1324, 1430, 1673, 2473, 2676, 2732, 2893, 2949, 3003, 3142, 3210, 3688, 3769, 4155, 4202, 4759, 4815, 4832, 4853, 4873, 5044, 5125, 5142, 5191, 5246, 5319, 5429, 5482, 5533, 5634, 5664, 5696, 5759, 5787, 5836, 5916], '(5159)': [423], 'Google': [424, 470, 533, 553, 601, 648, 681, 751, 790, 804, 875, 958, 988, 1015, 1132, 1154, 1182, 1202, 1245, 1287, 1326, 1432, 1675, 2475, 2678, 2704, 2734, 2895, 2921, 2951, 3005, 3102, 3144, 3174, 3191, 3212, 3415, 3435, 3493, 3690, 3771, 4157, 4204, 4744, 4761, 4817, 4834, 4855, 4875, 4985, 5046, 5089, 5104, 5127, 5144, 5165, 5193, 5248, 5278, 5295, 5321, 5431, 5484, 5535, 5636, 5666, 5698, 5761, 5789, 5838, 5903, 5918], 'Scholar).': [425, 471, 649, 682, 805, 876, 1246, 1288, 1327, 1433, 2476, 3006, 3103, 3213, 3494, 3691, 3772, 4158, 4205, 4876, 4986, 5047, 5194, 5322, 5485, 5536, 5667, 5699, 5790], 'Three': [426], 'expressed': [430, 1292, 1359, 2484, 2514, 3738, 4313, 4690, 4885], 'mammalian': [432], 'cells:': [433], 'D1,': [434, 1251, 4500], 'D2,': [435], 'D3.': [437, 4239, 4525], 'Activation': [438], 'CDK4/6': [440], 'promotes': [441], 'hyperphosphorylation': [442, 3892], 'retinoblastoma': [445, 3811, 3863], 'protein,': [446], 'release': [447], 'derepression': [449], 'E2F': [451], 'activity,': [452], '(2Harbour': [458], 'J.W.': [459, 1102, 2648, 2865], 'Dean': [460], 'D.C.': [461], '2000;': [464, 670, 955, 1284, 3133, 3171, 3206, 4741, 5237, 5275, 5315], '14:': [465], '2393-2409Crossref': [466], '(963)': [469], 'Genetic': [472], 'depletion': [473, 4581], 'mice': [476, 487, 555, 606, 5598], 'illustrated': [478], 'some': [479, 3310, 5566], 'non-overlapping': [480], 'roles': [481, 5568], 'cyclins.': [484, 4226], 'D1-deficient': [486], 'display': [488, 559, 607, 2443, 4893, 4929], 'defects': [489], 'caused': [490], 'reduced': [492, 3646, 3823, 3873, 3935, 3952, 3977, 4049, 4083, 5337], 'retinal': [495], 'mammary': [498], 'epithelial': [499], 'during': [501], 'pregnancy': [502], '(3Sicinski': [503], 'P.': [504, 567, 634, 717, 776, 1028, 1661, 2574, 2689, 2694, 2791, 2906, 2911, 3418, 3421, 3478, 4803, 5092, 5423, 5470, 5622, 5651, 5684, 5823], 'Donaher': [505, 568, 718], 'J.L.': [506, 569, 719], 'Parker': [507, 572, 722, 1063, 2609, 2826], 'S.B.': [508, 573, 723], 'Li': [509, 2682, 2899, 5133], 'T.': [510, 997, 3444, 5117], 'Fazeli': [511], 'A.': [512, 540, 966, 1060, 1064, 1096, 1098, 1100, 1157, 1165, 1223, 2606, 2610, 2642, 2644, 2646, 2712, 2722, 2823, 2827, 2859, 2861, 2863, 2929, 2939, 3162, 3166, 3403, 3423, 3460, 3484, 4837, 5077, 5098, 5147, 5170, 5266, 5270, 5647, 5749, 5782, 5819, 5881], 'Gardner': [513, 574, 724], 'H.': [514, 575, 632, 725, 774, 1022, 1036, 1074, 1114, 1659, 2568, 2582, 2620, 2660, 2708, 2785, 2799, 2837, 2877, 2925, 3442, 4801, 5468, 5620], 'Haslam': [515], 'S.Z.': [516], 'Bronson': [517, 588, 738], 'R.T.': [518, 589, 739], 'Elledge': [519, 590, 740], 'S.J.': [520, 591, 741, 3185, 5289], 'Weinberg': [521, 592, 667, 742], 'R.A.': [522, 593, 668, 743], 'Cell.': [523, 636, 669, 778, 1663, 4805, 5472, 5624, 5654, 5826], '1995;': [524, 547, 801], '82:': [525], '621-630Abstract': [526], 'Full': [527, 640, 642, 673, 675, 782, 784, 1146, 1148, 1174, 1176, 1424, 1426, 1667, 1669, 3136, 3138, 4809, 4811, 5240, 5242, 5476, 5478, 5628, 5630, 5658, 5660, 5830, 5832], 'Text': [528, 641, 643, 674, 676, 783, 785, 1147, 1149, 1175, 1177, 1425, 1427, 1668, 1670, 3137, 3139, 4810, 4812, 5241, 5243, 5477, 5479, 5629, 5631, 5659, 5661, 5831, 5833], 'PDF': [529, 644, 677, 786, 1150, 1178, 1428, 1671, 3140, 4813, 5244, 5480, 5632, 5662, 5834], '(897)': [532], 'Scholar,': [534, 752, 791, 959, 989, 1133, 1155, 1183, 2679, 2705, 2896, 2922, 3145, 3175, 3192, 3416, 3436, 4745, 4818, 4835, 4856, 5090, 5105, 5128, 5145, 5166, 5249, 5279, 5637, 5904], '4Fantl': [535], 'V.': [536, 1058, 2604, 2821, 3425, 5767], 'Stamp': [537], 'G.': [538, 974, 1088, 1094, 1137, 1159, 1189, 1231, 1415, 2634, 2640, 2683, 2851, 2857, 2900, 2992, 3148, 3156, 3158, 3482, 3677, 3758, 4144, 4191, 5033, 5107, 5134, 5252, 5260, 5262, 5522, 5889], 'Andrews': [539], 'Rosewell': [541], 'I.': [542, 614, 756, 1641, 2710, 2716, 2927, 2933, 4783, 5450, 5602], 'Dickson': [543], 'C.': [544, 621, 763, 1026, 1062, 1066, 1078, 1161, 1648, 2572, 2608, 2612, 2624, 2789, 2825, 2829, 2841, 3448, 3476, 4790, 5457, 5609], '9:': [548], '2364-2372Crossref': [549], '(606)': [552], 'Scholar),': [554, 602, 1676], 'lacking': [556], 'D2': [558], 'hypoplasia': [560], 'ovaries': [563], 'or': [564, 696, 890, 1813, 2026, 2110, 2115, 2360, 3027, 4594], 'testes': [565], '(5Sicinski': [566, 716], 'Geng': [570, 628, 720, 770, 1655, 4797, 5420, 5464, 5616], 'Y.': [571, 629, 721, 771, 1048, 1656, 2594, 2714, 2724, 2811, 2931, 2941, 4798, 5421, 5465, 5617], 'Park': [576, 726], 'M.Y.': [577, 727], 'Robker': [578, 728], 'R.L.': [579, 729, 5751], 'Richards': [580, 730], 'J.S.': [581, 731], 'McGinnis': [582, 732], 'L.K.': [583, 733], 'Biggers': [584, 734], 'J.D.': [585, 735], 'Eppig': [586, 736], 'J.J.': [587, 737, 4973], 'Nature.': [594, 744, 1125, 2671, 2888, 5424], '1996;': [595, 745, 1009, 4755, 4828], '384:': [596, 746], '470-474Crossref': [597, 747], '(597)': [600, 750], 'D3-deficient': [605], 'defective': [608], 'thymocyte': [609], 'maturation': [610], '(6Sicinska': [611, 1638, 4780, 5447, 5599], 'E.': [612, 754, 995, 1044, 1639, 2454, 2590, 2807, 4781, 4955, 5153, 5448, 5600, 5771], 'Aifantis': [613, 755, 1640, 4782, 5449, 5601], 'Le': [615, 757, 1642, 4784, 5451, 5603], 'Cam': [616, 758, 1643, 4785, 5452, 5604], 'L.': [617, 759, 1644, 3458, 4786, 4843, 4957, 5182, 5453, 5605, 5686], 'Swat': [618, 760, 1645, 4787, 5454, 5606], 'W.': [619, 761, 968, 1040, 1225, 1646, 2586, 2803, 4788, 5455, 5607, 5883], 'Borowski': [620, 762, 1647, 4789, 5456, 5608], 'Yu': [622, 764, 1649, 4791, 5458, 5610], 'Q.': [623, 765, 1650, 4792, 5419, 5459, 5611], 'Ferrando': [624, 766, 1651, 4793, 5460, 5612], 'A.A.': [625, 767, 1652, 4794, 5461, 5613], 'Levin': [626, 768, 1653, 4795, 5462, 5614], 'S.D.': [627, 769, 1654, 4796, 5463, 5615], 'von': [630, 772, 964, 1221, 1657, 4799, 5466, 5618, 5879], 'Boehmer': [631, 773, 1658, 4800, 5467, 5619], 'Sicinski': [633, 775, 1660, 4802, 5422, 5469, 5621], 'Cancer': [635, 777, 867, 953, 983, 1240, 1282, 1662, 2699, 2916, 3169, 3186, 3410, 3430, 4739, 4804, 4867, 4980, 5084, 5099, 5160, 5185, 5273, 5290, 5471, 5623, 5898], '2003;': [637, 779, 1143, 1171, 1421, 1664, 2701, 2918, 3412, 4806, 5086, 5121, 5162, 5473, 5625], '4:': [638, 780, 1665, 4807, 5474, 5626], '451-461Abstract': [639, 781, 1666, 4808, 5475, 5627], '(282)': [647, 789, 1674, 4816, 5483, 5635], 'A': [650, 1982, 3068, 3817, 3845, 3871, 3899, 3954, 3975, 4362, 4397, 4589], 'hallmark': [651], 'characteristic': [652], 'aberrant': [658, 708], '(7Hanahan': [665], 'D.': [666, 860, 978, 1082, 1235, 2628, 2845, 3446, 4847, 4963, 4965, 5157, 5643, 5815, 5893], '100:': [671], '57-70Abstract': [672], '(22628)': [680], 'overexpressed': [687, 4232], 'tumors': [690, 5409], 'due': [691, 1208, 3917, 4302, 5710], 'either': [692], 'gene': [694, 1215], 'amplification': [695, 1210], 'control': [698, 4037, 4073], 'pathways,': [701], 'this': [703, 1946, 4644, 5506, 5996], 'overexpression': [704, 5542], 'likely': [705, 5202], 'contributes': [706, 1376, 4002, 4023, 4113], 'many': [713, 4776], 'tumor': [714, 5070], 'types': [715, 1299, 3118, 4777, 5227], '6Sicinska': [753], '8Bartkova': [792], 'J.': [793, 795, 799, 865, 1007, 1034, 1056, 1080, 1140, 1168, 1312, 1314, 1318, 1418, 1705, 2580, 2602, 2626, 2718, 2726, 2797, 2819, 2843, 2935, 2943, 3130, 3198, 3204, 3429, 3468, 4747, 4751, 4753, 4820, 4824, 4826, 4841, 4845, 4858, 5109, 5135, 5234, 5307, 5313, 5645, 5682, 5817], 'Lukas': [794, 1313], 'Strauss': [796, 1315], 'M.': [797, 862, 976, 980, 1191, 1233, 1237, 1316, 2466, 2698, 2915, 2994, 3129, 3160, 3168, 3401, 3462, 3679, 3760, 4146, 4193, 4749, 4822, 4961, 4975, 5035, 5075, 5115, 5119, 5132, 5172, 5174, 5180, 5233, 5264, 5272, 5524, 5639, 5653, 5811, 5825, 5891, 5895, 5906], 'Bartek': [798, 1317, 4750, 4823], 'Oncogene.': [800, 1196, 1319, 2727, 2944, 2999, 3094, 3684, 3765, 4151, 4198, 4848, 5040, 5120, 5529, 5691, 5754], '10:': [802], '775-778PubMed': [803], 'Metastatic': [806], 'aggressive': [810], 'skin': [811, 910], 'cancer': [812, 4779, 5744], 'rising': [815], 'incidence': [816], 'rate.': [817], 'Currently,': [818], 'it': [819, 4333, 5841], 'only': [821, 3045], 'effectively': [822, 4566], 'treated': [823, 2208, 3579], 'detection': [826, 3511], 'surgery.': [828], 'Melanoma': [829, 2424, 2467, 4017], 'arises': [830], 'transformation': [833, 5395, 5442], 'melanocytes,': [835, 1365], 'pigment-producing': [837], 'skin,': [841], 'its': [843, 1306, 1340, 2545], 'well': [846], 'characterized': [847, 881], '(9Clark': [848], 'Jr.,': [849], 'W.H.': [850], 'Elder': [851, 2463, 2695, 2912], 'D.E.': [852, 2464, 2696, 2913, 4862], 'Guerry': [853], 'D.t.': [854], 'Braitman': [855], 'L.E.': [856], 'Trock': [857], 'B.J.': [858], 'Schultz': [859], 'Synnestvedt': [861], 'Halpern': [863], 'A.C.': [864], 'Natl.': [866, 5777], 'Inst.': [868], '1989;': [869], '81:': [870], '1893-1904Crossref': [871], '(1044)': [874], 'Radial': [877], 'growth': [878, 884, 901, 906, 1509, 2761, 2764, 2766, 2768, 2770, 4897], 'within': [885], 'epidermis': [887, 1465], '(in': [888], 'situ)': [889], 'as': [891, 1409, 1635, 1875, 2271, 3082, 3315, 4599, 4939], 'nests': [892], 'papillary': [895], 'dermal': [896], 'layer': [897], '(microinvasion).': [898], 'The': [899, 1440, 1710, 2775, 3773, 3958, 4293, 5374, 5583, 5721, 5944], 'vertical': [900, 2496, 2516], 'perpendicular': [907], 'surface': [911], 'gain': [914], 'tumorigenic': [916], 'properties.': [917], 'Subsequent': [918], 'metastasis': [919], 'distant': [923], 'sites': [924], 'poor': [929, 1269], 'prognosis.': [930], 'Expression': [931, 2416, 3372, 3722], 'primary': [938, 1936], 'metastatic': [940, 2503, 2520], '(10Florenes': [942, 1271, 4728], 'V.A.': [943, 993, 1272, 4729], 'Faye': [944, 1273, 4730], 'R.S.': [945, 1274, 4731], 'Maelandsmo': [946, 1275, 4732], 'G.M.': [947, 991, 1276, 4733], 'Nesland': [948, 1277, 4734], 'Holm': [950, 1000, 1279, 4736], 'R.': [951, 1001, 1046, 1054, 1072, 1116, 1120, 1280, 2592, 2600, 2618, 2662, 2666, 2809, 2817, 2835, 2879, 2883, 3152, 3440, 4737, 5256, 5641, 5680, 5813], 'Clin.': [952, 1281, 4738, 5136], 'Res.': [954, 984, 1241, 1283, 2468, 2700, 2917, 3170, 3187, 3411, 3431, 3489, 4740, 4868, 4981, 5085, 5100, 5161, 5186, 5274, 5291, 5899], '6:': [956, 1285, 4742, 5913], '3614-3620PubMed': [957, 1286, 4743], '11Sauter': [960], 'E.R.': [961, 1218, 5876], 'Yeo': [962, 1219, 5877], 'U.-C.': [963, 1220, 5878], 'Stemm': [965, 1222, 5880], 'Zhu': [967, 1224, 5882], 'Litwin': [969, 1226, 5884], 'S.': [970, 1030, 1032, 1052, 1068, 1070, 1227, 2462, 2576, 2578, 2598, 2614, 2616, 2793, 2795, 2815, 2831, 2833, 3194, 3407, 3464, 4860, 5081, 5303, 5649, 5690, 5781, 5821, 5885], 'Tichansky': [971, 1228, 5886], 'D.S.': [972, 1229, 5887], 'Pistritto': [973, 1230, 5888], 'Nesbit': [975, 1232, 5890], 'Pinkel': [977, 1234, 5892], 'Herlyn': [979, 1236, 1553, 2465, 2697, 2914, 5118, 5894, 5966], 'Bastian': [981, 1238, 5896], 'B.C.': [982, 1239, 5897], '2002;': [985, 1126, 1242, 2672, 2889, 5101, 5900], '62:': [986, 1243, 5102, 5901], '3200-3206PubMed': [987, 1244, 5902], '12Maelandsmo': [990], 'Florenes': [992], 'Hovig': [994], 'Oyjord': [996], 'Engebraaten': [998], 'O.': [999, 1005], 'Borresen': [1002], 'A.L.': [1003], 'Fodstad': [1004], 'Br.': [1006], 'Cancer.': [1008, 4754, 4827], '73:': [1010], '909-916Crossref': [1011], '(113)': [1014], 'Scholar)': [1016, 1203, 4762, 5296, 5762, 5919], 'constitutive': [1018], 'B-RAF-MEK-ERK1/2': [1019], '(13Davies': [1021], 'Bignell': [1023, 2569, 2786], 'G.R.': [1024, 2570, 2787], 'Cox': [1025, 2571, 2788], 'Stephens': [1027, 2573, 2790], 'Edkins': [1029, 2575, 2792], 'Clegg': [1031, 2577, 2794], 'Teague': [1033, 2579, 2796], 'Woffendin': [1035, 2581, 2798], 'Garnett': [1037, 2583, 2800], 'M.J.': [1038, 2584, 2801], 'Bottomley': [1039, 2585, 2802], 'Davis': [1041, 2587, 2804, 3443], 'N.': [1042, 1086, 2588, 2632, 2805, 2849, 3127, 4959, 4969, 5231], 'Dicks': [1043, 2589, 2806], 'Ewing': [1045, 2591, 2808], 'Floyd': [1047, 2593, 2810], 'Gray': [1049, 2595, 2812], 'K.': [1050, 1084, 1193, 2452, 2596, 2630, 2681, 2720, 2813, 2847, 2898, 2937, 2996, 3091, 3681, 3762, 4148, 4195, 4977, 5037, 5526], 'Hall': [1051, 2597, 2814], 'Hawes': [1053, 2599, 2816], 'Hughes': [1055, 2601, 2818], 'Kosmidou': [1057, 2603, 2820], 'Menzies': [1059, 2605, 2822], 'Mould': [1061, 2607, 2824], 'Stevens': [1065, 2611, 2828], 'Watt': [1067, 2613, 2830], 'Hooper': [1069, 2615, 2832], 'Wilson': [1071, 2617, 2834], 'Jayatilake': [1073, 2619, 2836], 'Gusterson': [1075, 2621, 2838], 'B.A.': [1076, 2622, 2839], 'Cooper': [1077, 2623, 2840], 'Shipley': [1079, 2625, 2842], 'Hargrave': [1081, 2627, 2844], 'Pritchard-Jones': [1083, 2629, 2846], 'Maitland': [1085, 2631, 2848], 'Chenevix-Trench': [1087, 2633, 2850], 'Riggins': [1089, 2635, 2852], 'G.J.': [1090, 2636, 2853], 'Bigner': [1091, 2637, 2854], 'D.D.': [1092, 2638, 2855], 'Palmieri': [1093, 2639, 2856], 'Cossu': [1095, 2641, 2858], 'Flanagan': [1097, 2643, 2860], 'Nicholson': [1099, 2645, 2862], 'Ho': [1101, 2647, 2864], 'Leung': [1103, 2649, 2866], 'S.Y.': [1104, 2650, 2867], 'Yuen': [1105, 2651, 2868], 'S.T.': [1106, 2652, 2869], 'Weber': [1107, 2653, 2690, 2870, 2907], 'B.L.': [1108, 2654, 2691, 2871, 2908], 'Seigler': [1109, 2655, 2872], 'H.F.': [1110, 2656, 2873], 'Darrow': [1111, 2657, 2874], 'T.L.': [1112, 2658, 2875], 'Paterson': [1113, 2659, 2876], 'Marais': [1115, 2661, 2878], 'Marshall': [1117, 2663, 2880], 'Wooster': [1119, 2665, 2882], 'Stratton': [1121, 2667, 2884], 'M.R.': [1122, 2668, 2685, 2885, 2902], 'Futreal': [1123, 2669, 2886], 'P.A.': [1124, 2670, 2887, 3486], '417:': [1127, 2673, 2890], '949-954Crossref': [1128, 2674, 2891], '(8397)': [1131, 2677, 2894], '14Conner': [1134], 'S.R.': [1135, 1413], 'Scott': [1136, 1414], 'Aplin': [1138, 1194, 1416, 2997, 3092, 3682, 3763, 4149, 4196, 5038, 5527], 'A.E.': [1139, 1195, 1417, 2998, 3093, 3683, 3764, 4150, 4197, 5039, 5528], 'Biol.': [1141, 1169, 1419, 3131, 5235], 'Chem.': [1142, 1170, 1420, 3132, 5236], '278:': [1144, 1172, 1422], '34548-34554Abstract': [1145, 1423], '(47)': [1153, 1431], '15Calipel': [1156], 'Lefevre': [1158], 'Pouponnot': [1160], 'Mouriaux': [1162], 'F.': [1163, 1167, 5113], 'Eychene': [1164], 'Mascarelli': [1166], '42409-42418Abstract': [1173], '(106)': [1181], '16Bhatt': [1184], 'K.V.': [1185, 2988, 3673, 3754, 4140, 4187, 5029, 5518], 'Spofford': [1186, 2989, 3674, 3755, 4141, 4188, 5030, 5519], 'L.S.': [1187, 2990, 3675, 3756, 4142, 4189, 5031, 5520], 'Aram': [1188, 2991, 3676, 3757, 4143, 4190, 5032, 5521], 'McMullen': [1190, 2993, 3678, 3759, 4145, 4192, 5034, 5523], 'Pumiglia': [1192, 2995, 3680, 3761, 4147, 4194, 5036, 5525], '2005;': [1197, 3000, 3685, 3766, 4152, 4199, 4982, 5041, 5138, 5530], '12:': [1198, 3001, 3686, 3767, 4153, 4200, 5042, 5531], '3459-3471Crossref': [1199, 3002, 3687, 3768, 4154, 4201, 5043, 5532], '(124)': [1201, 3004, 3689, 3770, 4156, 4203, 5045, 5534], 'or,': [1204], 'acral': [1206], 'melanoma,': [1207], 'locus': [1216], '(11Sauter': [1217, 5875], 'addition': [1248, 2381, 4129, 4305, 5509], 'readily': [1256, 3355], 'detected': [1257, 2049, 3356, 3363, 4344, 4476], 'immunohistochemical': [1259], 'on': [1261, 2290, 3020, 3047, 3052, 3064, 3606, 3641, 3663, 3802, 3891, 3910, 4169, 4395, 4633, 4725, 5010], 'tissue': [1263, 1457, 4726, 5954], 'prognosis': [1270], 'wide': [1295], 'variety': [1296], 'other': [1303, 4934, 5225, 5718, 5873], 'poorly': [1309, 3362], 'understood': [1310], '(17Bartkova': [1311], '1998;': [1320, 5755], '17:': [1321], '1027-1037Crossref': [1322], '(176)': [1325], 'Because': [1328, 4543], 'remains': [1336], 'unknown,': [1337], 'analyzed': [1339, 2223, 2427, 4423], 'contribution': [1343], 'find': [1353], 'aberrantly': [1358], 'fibronectin': [1370, 2107, 2119, 3041, 3053, 3221, 3249, 3280], 'adhesion-dependent': [1371, 4662], 'kinase/Akt': [1373, 3110, 3225, 3285, 4664, 5065, 5210], 'pathway,': [1374], 'progression.': [1380, 4007, 4921], 'Notably,': [1381, 2544, 4608], 'CDK': [1385, 4490, 4709, 5719], 'partners': [1387, 4492, 5575], 'show': [1391, 2530, 4376, 4647, 4879, 5487, 5540, 5672, 5858], 'differences': [1393], 'Cell': [1398, 1974, 2060, 3727, 5909], 'Culture—Normal': [1399], '(NHEM)': [1403], 'were': [1404, 1437, 1470, 1522, 1534, 1547, 1561, 1589, 1614, 1627, 1805, 1843, 1851, 1865, 1873, 1897, 1903, 1915, 2017, 2040, 2063, 2071, 2091, 2125, 2145, 2172, 2190, 2206, 2241, 2265, 2299, 2318, 2328, 2364, 2398, 3613, 3698, 3872, 3926, 3976, 4264, 4455, 4466, 4504], 'isolated': [1405], 'neonatal': [1407], 'foreskins': [1408, 1436], 'described': [1411, 5735], '(14Conner': [1412], 'brief,': [1435], 'obtained': [1438, 5356], 'Birth': [1441, 5945], 'Place': [1442, 5946], 'at': [1443, 1603, 1939, 2035, 2128, 2161, 2186, 2217, 2252, 2258, 2370, 3119, 3258, 3812, 3864, 4314, 4627, 5297, 5564, 5947], 'Albany': [1444, 5948], 'Medical': [1445, 1708, 5949], 'Center': [1446, 5950], 'accordance': [1448], 'Institutional': [1451], 'Review': [1452], 'Board': [1453], 'approved': [1454], 'protocol.': [1455], 'Foreskin': [1456], 'incubated': [1459, 1852, 1934, 2023, 2365], 'dispase': [1461], 'separate': [1463], 'dermis.': [1468], 'Cells': [1469, 1613, 2070, 2090, 2189, 3036], 'removed': [1471, 4456], 'sheets': [1474], 'trypsinization': [1476], 'cultured': [1478, 1562], 'MCDB': [1480, 1564, 2074, 2098], '153': [1481, 1565, 2075], 'medium': [1482, 1566, 2076, 2160], '(Sigma)': [1483, 2082, 2124], 'containing': [1484, 1567, 1920, 2077, 2201, 2332], '0.2%': [1485, 1576], '(w/v)': [1486], 'sodium': [1487, 1577], 'bicarbonate,': [1488, 1578], '0.5%': [1489, 2078, 2100, 2202], '(v/v)': [1490, 1495], 'fetal': [1491, 1573], 'bovine': [1492, 1496, 1574, 1922, 2079, 2101], 'serum,': [1493, 1575], '0.05%': [1494], 'pituitary': [1497], 'extract,': [1498], '0.5': [1499], 'μg/ml': [1500, 1503, 1581, 1869, 2254], 'hydrocortisone,': [1501], '10': [1502, 1521, 2132, 2184, 2256, 3381], 'insulin,': [1504], '1': [1505, 1930, 2033, 2084, 2253, 2341, 2344, 2564, 3307], 'ng/ml': [1506], 'basic': [1507], 'fibroblast': [1508], 'factor,': [1510], '8': [1512, 2169], 'nm': [1513, 1609], '12-O-tetradecanoylphorbol-13-acetate.': [1514], 'NHEM': [1515, 2524], 'between': [1517, 5593], 'passages': [1518], '3': [1519, 3089], 'experiments.': [1525], 'Human': [1526, 2118, 2423], 'SK-MEL-5,': [1528], 'SK-MEL-24,': [1529], 'SK-MEL-28': [1531, 1587, 2504, 3277, 3618, 3631, 3966, 5342, 5371], 'purchased': [1535], 'ATCC': [1537], '(Manassas,': [1538], 'VA).': [1539], 'WM793,': [1540], 'WM115,': [1541, 5975], 'WM278,': [1542, 5976], 'WM35,': [1543, 5973], 'SBcl2': [1545, 2558], 'kindly': [1548], 'donated': [1549], 'Dr.': [1551, 1704, 5964, 5982, 5990], 'Meenhard': [1552, 5965], '(Wistar': [1554, 5967], 'Institute,': [1555, 5968], 'Philadelphia).': [1556], 'All': [1557, 3330], '20%': [1568], 'Leibovitz': [1569], 'L-15': [1570], 'medium,': [1571], '2%': [1572], '5': [1580, 1868, 2196], 'insulin.': [1582], 'Interference': [1584], '(RNAi)—WM793': [1585], 'transfected': [1590, 3838], '4': [1592, 1940, 2371], 'h': [1593, 1846, 1855, 1931, 2034, 2170], 'chemically': [1595], 'synthesized': [1596], '(siRNA;': [1599], 'Dharmacon,': [1600], 'Lafayette,': [1601], 'CO)': [1602], 'final': [1605, 2163], 'concentration': [1606, 2130, 2164], '25': [1608], 'using': [1610, 1784, 2042, 2052, 2301, 2308, 2324], 'OligofectAMINE': [1611], '(Invitrogen).': [1612, 2089], 'harvested': [1615], 'after': [1616, 2139, 3274, 3615, 4050, 4443], 'further': [1618, 2191, 2390, 3563], '68': [1619], 'h.': [1620, 2117, 2394], 'For': [1621, 1684, 1848, 2261, 2313], 'two': [1624, 3803], 'distinct': [1625, 2526, 3886], 'sequences': [1626, 1773], 'used:': [1628], 'siRNA': [1631, 1680, 1688, 3538, 3831, 3842, 3887, 4563], '#1': [1632], '5′-GGAUCUUUGUGGCCAAGGAdTdT-3′,': [1634], 'utilized': [1637, 3528, 3784, 4241, 4554], '#2': [1681], '5′-GAUUAUACCUUUGCCAUGUUU-3′.': [1683], 'PTEN': [1685, 3508, 3514, 3521, 3533, 3541, 3549], 'knockdown,': [1686, 2142], 'sequence': [1689, 1713], '5′-GUGAAGAUCUUGACCAAUGUU-3′.': [1692], 'Recombinant': [1693], 'Lentiviral': [1694], 'Transduction—Full-length': [1695], 'cDNA': [1699], 'gift': [1702], 'Zhao': [1706, 5984], '(Albany': [1707], 'College).': [1709], 'subcloned': [1715], 'pEN-TR™/D-TOPO': [1717], 'vector': [1718], '(Invitrogen)': [1719, 1792, 1815, 1821, 2362], 'according': [1720, 1822], "manufacturer's": [1723, 1825], 'guidelines.': [1724], 'To': [1725, 3007, 3214, 3516, 3562, 3921, 4227], 'generate': [1726, 1794], 'blunt-ended': [1728], 'PCR': [1729], 'products': [1730], 'TOPO': [1732], 'cloning,': [1733], 'KOD': [1737], 'Hot': [1738], 'Start': [1739], 'DNA': [1740, 1802], 'polymerase': [1741], 'kit': [1742, 1789], '(Novagen,': [1743], 'Darmstadt,': [1744], 'Germany)': [1745], 'reverse': [1748], 'primer': [1749], 'omits': [1751], 'stop': [1753], 'codon': [1754], 'order': [1756], 'put': [1758], 'open': [1760], 'reading': [1761, 5995], 'frame': [1762], 'in-frame': [1763], 'V5': [1766, 1887, 2361, 4252, 4273, 4308], 'epitope': [1767, 4309], 'tag': [1768, 4310], 'built': [1769], 'pLenti6/UbC/V5-DEST.': [1771], 'Primer': [1772], 'available': [1775], 'upon': [1776, 4637], 'request.': [1777], 'pENTR/d-TOPO/cyclin': [1778], 'recombined': [1781], 'pLenti6/UbC/V5-DEST': [1783], 'LR': [1786], 'Clonase': [1787], 'II': [1788], 'protocol': [1791], 'pLenti6/UbC/V5-GW/cyclin': [1795, 1811], 'This': [1797, 2373, 4122, 4623, 5003], 'construct': [1798], 'verified': [1800], 'sequencing.': [1803], 'Lentiviruses': [1804], 'generated': [1806], 'cotransfecting': [1808], '293FT': [1809], 'pLenti6/UbC/V5-GW/LacZ': [1814], 'three': [1817, 2400, 3331], 'lentiviral': [1818, 1860, 4243], 'packaging': [1819], 'plasmids': [1820], 'guidelines,': [1826], 'exception': [1829], 'FuGENE': [1831], '6': [1832, 4431], 'reagent': [1833, 2245], '(Roche': [1834], 'Applied': [1835], 'Science)': [1836], 'transfection.': [1840], 'Viral': [1841], 'supernatants': [1842], 'collected': [1844], '72': [1845, 1854], 'post-transfection.': [1847], 'transduction,': [1849], 'presence': [1858, 5737], 'supernatant.': [1861], 'Transduced': [1862], 'populations': [1864], 'selected': [1866], 'blasticidin.': [1870], 'Transduction': [1871], 'efficiencies': [1872], '>70%,': [1874], 'judged': [1876], 'transduction': [1878, 4244], 'green': [1880], 'fluorescent': [1881], 'lentivirus': [1882], 'immunostaining': [1884], 'tag.': [1888], 'SDS-PAGE': [1889, 2409], 'Western': [1891, 2038, 2478, 4266, 4434], 'Blotting—Cells': [1892], 'lysed': [1893, 2329], 'sample': [1895, 2410], 'buffer': [1896, 2331, 2405, 2411], 'separated': [1898], 'SDS-PAGE,': [1900], 'proteins': [1902], 'transferred': [1904], 'electrophoretically': [1905], 'onto': [1906, 2106, 2147], 'Immobilon': [1907], 'P': [1908], 'membranes': [1909], '(Millipore': [1910], 'Corp.,': [1911], 'Bedford,': [1912], 'MA).': [1913, 2239], 'Membranes': [1914, 2016], 'blocked': [1916], 'phosphate-buffered': [1918, 2020, 2175, 2199], 'saline': [1919, 2176, 2200], '1%': [1921, 2348], 'serum': [1923, 2080, 2102], 'albumin': [1924, 2081, 2103], '0.1%': [1926], 'Tween': [1927], '20': [1928], 'subsequently': [1933], 'antibody': [1937, 2228, 4274], 'overnight': [1938, 2065, 2369], '°C.': [1941, 2219, 2372], 'Primary': [1942], 'antibodies': [1943, 2363, 4462], 'study': [1947, 4645], 'were:': [1948], 'Akt': [1949, 2963, 3242, 3256, 3271, 3352, 3496, 3557, 3596, 3607], '(clone': [1950, 1953, 1987, 2010], '55),': [1951], '97),': [1954], '(DCS-6),': [1958], 'all': [1959, 1972, 1989], 'BD': [1961], 'Biosciences;': [1962], 'phospho-473': [1963], 'Akt,': [1964, 3238, 3392, 3526], '(DCS-83),': [1966], 'phospho-ERK1/2,': [1967], 'phospho-Ser-780': [1968], 'Rb,': [1969], 'Signaling': [1975, 3299], 'Technology,': [1976], 'Beverley,': [1977], 'MA;': [1978], 'CDK2': [1979, 4512, 4619, 5728], '(M2),': [1980], '(H-432),': [1983], 'total': [1985, 4224], 'ERK1/2': [1986, 3649], 'K-23),': [1988], 'Santa': [1991, 1994, 2358], 'Cruz': [1992], 'Biotechnology,': [1993], 'Cruz,': [1995], 'CA;': [1996, 2003], '(DCS-22),': [1999], 'Lab-Vision,': [2001], 'Fremont,': [2002], 'β-galactosidase,': [2004], 'Promega,': [2006], 'Madison': [2007], 'WI;': [2008], 'tubulin': [2009], 'KMX-1),': [2011], 'Chemicon,': [2013], 'Temecula,': [2014], 'CA.': [2015], 'washed': [2018, 2092, 2173, 2192, 2399], 'saline/Tween,': [2021], 'anti-mouse': [2025], 'anti-rabbit': [2027, 2280], 'IgG': [2028, 2232], 'peroxidase': [2029], 'conjugates': [2030], '(Calbiochem)': [2031], 'room': [2036, 2187, 2259], 'temperature.': [2037, 2188, 2260], 'blots': [2039], 'developed': [2041], 'SuperSignal': [2043], 'chemiluminescent': [2044], 'substrate': [2045], '(Pierce).': [2046], 'Immunoreactivity': [2047], 'quantified': [2051], 'Fluor-S': [2054], 'Multi-Imager': [2055], 'Quantity-One': [2057], 'software': [2058], '(Bio-Rad).': [2059], 'Adhesion—WM793': [2061], 'serum-starved': [2064], 'before': [2066, 4441], 'detachment': [2067], 'trypsin.': [2069], 'pelleted': [2072], 'mg/ml': [2085], 'soybean': [2086], 'trypsin': [2087, 2321], 'inhibitor': [2088, 5334], 'once': [2093], 'then': [2095, 2153, 2178, 2207], 'resuspended': [2096], '153,': [2099], 're-plated': [2105], '(BD': [2108, 2120], 'Biosciences)': [2109, 2121], 'poly-lysine-coated': [2111], 'dishes': [2112], '16': [2114], '24': [2116], 'poly-lysine': [2123, 3028, 3043, 3065, 3254], 'both': [2126, 3040, 4414, 5797], 'μg/ml.': [2133], 'Immunofluorescence—For': [2134], 'analysis': [2135, 4436], 'S-phase': [2137, 4012], 'WM793': [2143, 2498, 3018, 3049, 3073, 3217, 3246, 3327, 3358, 3499, 3580, 3751, 3833, 3931, 4065, 4561, 5358, 5978], 'replated': [2146, 3017, 3051], 'coverslips': [2148], '12': [2150], 'h,': [2151], 'bromodeoxyuridine': [2154], '(BrdUrd)': [2155], 'added': [2157], '100': [2166], 'μm.': [2167], 'After': [2168], 'fixed': [2179, 2266], '3.7%': [2181], 'formaldehyde': [2182, 2268], 'min': [2185, 2197, 2216, 2257], 'permeabilized': [2194], 'Triton': [2203, 2349], 'X-100.': [2204, 2350], 'Slides': [2205], '0.1': [2210], 'units/μl': [2211], 'DNase': [2213], '30': [2215], '37': [2218], 'BrdUrd': [2220, 4045, 4068], 'incorporation': [2221, 4030, 4046], 'sheep': [2226], 'anti-BrdUrd': [2227], 'rabbit': [2230], 'anti-sheep': [2231], 'conjugated': [2233], 'fluorescein': [2235], 'isothiocyanate': [2236], '(Biodesign,': [2237], 'Saco,': [2238], 'Nuclei': [2240], 'stained': [2242, 2274], 'Hoechst': [2244], '33342': [2246], '(Molecular': [2247, 2283], 'Probes': [2248], 'Inc.': [2249], 'Eugene,': [2250], 'OR)': [2251], 'Ki67': [2262, 4094], 'staining': [2263, 2287, 3085, 4088, 4604], 'processed': [2270, 2307], 'above': [2272], 'anti-Ki67': [2276], '(RB-9043,': [2277], 'Lab-Vision)': [2278], 'Alexa-Fluor': [2281], '488': [2282], 'Probes)': [2284], 'antibodies.': [2285], 'Fluorescent': [2286], 'viewed': [2289], 'Olympus': [2292], 'BX60': [2293], 'microscope': [2294], 'equipped': [2295], 'epifluorescence.': [2297], 'Images': [2298], 'captured': [2300], 'Spot': [2303], 'CCD': [2304], 'camera': [2305], 'deconvolution': [2309], 'Slide': [2310], 'Book': [2311], 'software.': [2312], 'counting': [2315], 'experiments,': [2316, 5326], 'detached': [2319], 'counted': [2323], 'hemocytometer.': [2326], 'Immunoprecipitation—Cells': [2327], '50': [2333], 'mm': [2334, 2339, 2342, 2345], 'Tris,': [2335], 'pH': [2336], '7.5,': [2337], '150': [2338], 'NaCl,': [2340], 'EDTA,': [2343], 'EGTA,': [2346], '(Ab-3,': [2353], 'Lab-Vision),': [2354], '(M-20,': [2357], 'Cruz),': [2359], 'lysates': [2368, 3232, 4270, 4440], 'followed': [2375], 'next': [2377], 'day': [2378], '40': [2383], 'μl': [2384], 'A/G': [2387], 'agarose': [2388], 'incubation': [2391], '2': [2393], 'Protein': [2395], 'A/G-agarose': [2396], 'complexes': [2397, 4335, 5671, 5741, 5847], 'times': [2401], 'cold': [2403], 'lysis': [2404], 'boiled': [2407], 'dissociate': [2413], 'proteins.': [2415], 'Is': [2420, 3723], 'Enhanced': [2421, 3495, 4712], 'Cells—We': [2425], 'initially': [2426], 'whether': [2428, 3009, 3216, 4020], 'characteristics': [2444, 4894], 'different': [2446, 4536, 4631, 5398], 'stages': [2447], '(18Satyamoorthy': [2451], 'DeJesus': [2453], 'Linnenbach': [2455], 'A.J.': [2456], 'Kraj': [2457], 'B.': [2458, 3450, 5688], 'Kornreich': [2459], 'D.L.': [2460, 5096, 5130], 'Rendle': [2461], '1997;': [2469, 3432, 3490], '7:': [2470], '35-42Crossref': [2471], '(136)': [2474], 'By': [2477], 'blot': [2479, 4435], 'analysis,': [2480], 'highly': [2485, 3737, 4689, 4884], 'radial': [2488, 4896], 'growth-phase': [2489, 2497, 2517], 'WM35': [2492], 'SBcl2,': [2494, 5974], 'WM115': [2500, 3360, 3501], 'cells,': [2501, 2519, 2522, 3229, 4421, 4612], 'SK-MEL-5': [2506, 3701], '(Fig.': [2508, 3066, 3261, 3281, 3370, 3545, 3602, 3622, 3654, 3843, 3900, 3956, 3987, 4054, 4099, 4105, 4291, 4338, 4372, 4463, 4486, 4510], '1).': [2509], 'weakly': [2513], 'WM278': [2518, 3316, 3368, 3535, 3543], 'SK-MEL-24': [2521], 'donors.': [2527], 'These': [2528, 4107, 4374, 4526], 'lines.': [2543], 'does': [2547, 5546], 'tightly': [2549], 'correlate': [2550], 'B-RAF': [2555, 2562, 2746, 2776, 4906], 'mutations': [2556, 4907], 'because': [2557], 'express': [2560, 3317, 3336, 4905], 'wild-type': [2561, 5808], '(Table': [2563], 'Refs.': [2566, 2753, 2783], '13Davies': [2567, 2784], '19Satyamoorthy': [2680, 2897], 'Gerrero': [2684, 2901], 'Brose': [2686, 2903], 'M.S.': [2687, 2904, 5908], 'Volpe': [2688, 2905], 'van': [2692, 2909, 4970], 'Belle': [2693, 2910], '63:': [2702, 2919, 3413, 5087, 5163], '756-759PubMed': [2703, 2920], '20Tanami': [2707, 2924], 'Imoto': [2709, 2926], 'Hirasawa': [2711, 2928], 'Yuki': [2713, 2930], 'Sonoda': [2715, 2932], 'Inoue': [2717, 2934], 'Yasui': [2719, 2936], 'Misawa-Furihata': [2721, 2938], 'Kawakami': [2723, 2940], 'Inazawa': [2725, 2942], '2004;': [2728, 2945, 4869, 5187, 5655, 5692, 5827], '23:': [2729, 2946, 5139, 5693], '8796-8804Crossref': [2730, 2947], '(73)': [2733, 2950], 'Scholar).TABLE': [2735], '1Cyclin': [2736], 'linesCell': [2742], 'lineMelanoma': [2743], 'stageB-RAF': [2744], 'statusaThe': [2745], 'statuses': [2747, 2777], '13,': [2754], '19,': [2755], '20Cyclin': [2757], 'expressionNHEMWild': [2759], 'typeLowSBcl2Radial': [2760], 'phaseWild': [2762], 'typeHighWM35Radial': [2763], 'phaseV600EHighWM793Vertical': [2765], 'phaseV600EHighWM115Vertical': [2767], 'phaseV600DHighWM278Vertical': [2769], 'phaseV600ELowSK-MEL-5Metastatic': [2771], 'melanomaV600EHighSK-MEL-24Metastatic': [2772], 'melanomaV600ELowSK-MEL-28Metastatic': [2773], 'melanomaV600EHigha': [2774], 'Scholar': [2952], 'Open': [2953], 'table': [2954], 'new': [2957], 'tab': [2958], 'Levels': [2961], 'Phosphorylation': [2964], 'Are': [2965], 'Regulated': [2966], 'Adhesion': [2968, 3244], 'Fibronectin—We': [2970], 'independent': [2981], 'integrin-mediated': [2983], 'adhesion': [2984, 3219, 3275, 4993], 'spreading': [2986], '(16Bhatt': [2987, 3672, 3753, 4139, 4186, 5028, 5517], 'determine': [3008, 3517, 4019], 'adhesion,': [3015], 'fibronectin,': [3021], 'matrix': [3023], 'engages': [3025], 'integrins,': [3026], 'which': [3030, 5377], 'attach': [3032], 'independently': [3033], 'integrins.': [3035], 'attached': [3037], 'efficiently': [3038, 3539, 4247, 5933], 'spread': [3046], 'fibronectin.': [3048], 'levels': [3056, 3234, 3319, 3342, 3601, 3644, 3716, 3789, 3868, 4316, 4503, 4772, 5023, 5340], 'comparison': [3061, 3984], '2,': [3067, 3262, 4428], 'quantitated': [3070, 3847], 'B).': [3072, 3849], 'undergo': [3077], 'apoptosis': [3078], 'conditions,': [3081], 'determined': [3083, 3799, 4600], 'cleaved': [3087], 'caspase': [3088], '(21Boisvert-Adamo': [3090], '2006;': [3095], '(Epub': [3096], 'ahead': [3097], 'print': [3099], 'PMID:': [3100], '16547495)PubMed': [3101], 'Previous': [3104], 'reports': [3105], 'regulates': [3112, 3713], 'non-melanoma': [3116], 'level': [3121, 4222, 5299], 'translation': [3123, 5301], '(22Feng': [3124, 5228], 'L.X.': [3125, 5229], 'Ravindranath': [3126, 5230], 'Dym': [3128, 5232], '275:': [3134, 5238], '25572-25576Abstract': [3135, 5239], '(215)': [3143, 5247], '23De': [3146, 5250], 'Vita': [3147, 5251], 'Berlingieri': [3149, 5253], 'M.T.': [3150, 5151, 5254], 'Visconti': [3151, 5255], 'Castellone': [3153, 5257], 'M.D.': [3154, 5258], 'Viglietto': [3155, 5259], 'Baldassarre': [3157, 5261], 'Zannini': [3159, 5263], 'Bellacosa': [3161, 5265], 'Tsichlis': [3163, 5267], 'P.N.': [3164, 5268], 'Fusco': [3165, 5269], 'Santoro': [3167, 5271], '60:': [3172, 5276], '3916-3920PubMed': [3173, 5277], '24Zhu': [3176, 5280], 'X.': [3177, 5111, 5281], 'Kwon': [3178, 5282], 'C.H.': [3179, 5283], 'Schlosshauer': [3180, 5284], 'P.W.': [3181, 5285], 'Ellenson': [3182, 5286], 'L.H.': [3183, 5287], 'Baker': [3184, 5288], '2001;': [3188, 5292, 5425], '61:': [3189, 5293], '4569-4575PubMed': [3190, 5294], '25Naderi': [3193], 'Gutzkow': [3195, 5304], 'K.B.': [3196, 5305], 'Christoffersen': [3197, 5306], 'Smeland': [3199, 5308], 'E.B.': [3200, 5309], 'Blomhoff': [3201, 5310], 'H.K.': [3202, 5311], 'Eur.': [3203, 5312], 'Immunol.': [3205, 5314], '30:': [3207, 5316], '1757-1768Crossref': [3208, 5317], '(36)': [3211, 5320], 'investigate': [3215], 'pathway': [3226, 5066, 5353], 'probed': [3231], 'serine': [3236, 3259, 3267, 3813, 3865], '473-phosphorylated': [3237], 'indicator': [3240], 'activation.': [3243], 'attachment': [3252], 'phosphorylation': [3257, 3269, 3353, 3497, 3555, 3597, 3608, 3647, 3809, 3861], '473': [3260, 3268], 'C': [3263], 'D).': [3265], 'Similarly,': [3266], '2E).': [3282], 'Thus,': [3283, 3706], 'adhesion-regulated': [3293], 'Kinase': [3298], 'Regulates': [3300], 'Expression—Our': [3303], 'Fig.': [3306, 4578, 4592, 4606, 4621], 'such': [3314, 4938], 'low': [3318, 4942], 'including': [3326, 4890, 5370], 'WM115.': [3329], 'examined': [3340], 'phospho-Akt': [3344], 'observed': [3350, 3614, 3699, 5592], '3A).': [3371], '(PTEN),': [3382], 'lipid': [3384], 'inhibits': [3387], 'kinase': [3389, 3586, 3708, 4996, 5215], '(26Stahl': [3398, 5072], 'Cheung': [3400, 5074, 5171], 'Sharma': [3402, 5076, 5169], 'Trivedi': [3404, 5078], 'N.R.': [3405, 5079], 'Shanmugam': [3406, 5080], 'Robertson': [3408, 5082, 5183], 'G.P.': [3409, 5083, 5184], '2881-2890PubMed': [3414, 5088], '27Guldberg': [3417], 'thor': [3419], 'Straten': [3420], 'Birck': [3422], 'Ahrenkiel': [3424], 'Kirkin': [3426], 'A.F.': [3427], 'Zeuthen': [3428], '57:': [3433, 3491], '3660-3663PubMed': [3434], '28Teng': [3437], 'D.H.': [3438], 'Hu': [3439, 4859], 'Lin': [3441], 'Iliev': [3445], 'Frye': [3447], 'Swedlund': [3449], 'Hansen': [3451], 'K.L.': [3452, 3456], 'Vinson': [3453], 'V.L.': [3454], 'Gumpper': [3455], 'Ellis': [3457, 5095], 'El-Naggar': [3459], 'Frazier': [3461], 'Jasser': [3463], 'Langford': [3465], 'L.A.': [3466], 'Lee': [3467], 'Mills': [3469, 4956], 'G.B.': [3470], 'Pershouse': [3471], 'M.A.': [3472, 4839], 'Pollack': [3473], 'R.E.': [3474], 'Tornos': [3475], 'Troncoso': [3477], 'Yung': [3479], 'W.K.': [3480], 'Fujii': [3481], 'Berson': [3483], 'Steck': [3485], 'et': [3487], 'al.Cancer': [3488], '5221-5225PubMed': [3492], 'correlated': [3503], 'decreased': [3505, 4102], 'truncated': [3513], 'products.': [3515], 'subsequent': [3523], 'activation': [3524], 'RNAi': [3529, 3785, 3940, 4555], 'knock': [3531, 3787, 4557], 'down': [3532, 3788, 4237, 4558, 4568], 'PTEN-targeting': [3537], 'down-regulated': [3540], '3B).': [3546], 'Concomitant': [3547], 'down-regulation': [3550], 'increase': [3553], 'expression.': [3561, 3818, 4398], 'examine': [3564], 'kinase-Akt': [3569], 'expression,': [3577, 4933], 'LY294002,': [3583], 'inhibitor.': [3587], 'LY294002': [3588, 3621], 'treatment': [3589, 3616, 3629, 5327], 'decrease': [3594, 4359], '3C).': [3603], 'Comparable': [3604], '3,': [3623, 3655], 'D': [3624, 3656], 'E).': [3626], 'contrast,': [3628], 'U0126,': [3634], 'inhibitor,': [3637], 'had': [3638], 'no': [3639], 'effect': [3640], 'E);': [3658], 'U0126': [3662], 'consistent': [3667, 5587], 'our': [3669, 3924, 4695, 5007, 5324, 5538, 5554, 5856], 'previous': [3670, 5008], 'report': [3671], 'Similar': [3692], 'results': [3693, 3925, 4108, 4375], 'utilizing': [3694], 'pharmacological': [3696], 'inhibitors': [3697], '(data': [3703, 5344], 'shown).': [3705, 5346], 'Required': [3724], 'Cycle': [3728], 'Progression—We': [3729], 'reported': [3732], 'required': [3740, 4671], 'requirement': [3774, 4123, 4175, 4218, 5513], 'known.': [3782], 'B-RAF-expressing': [3795], 'markers': [3804], 'G1:': [3808], '780': [3814, 3866], 'average': [3826], '84%': [3828], 'targeting': [3830, 4564, 5922], 'non-targeting': [3841], '4,': [3844, 4429], 'Importantly,': [3850, 4348, 4666, 4877], 'knockdown': [3853, 3909, 3950, 3962, 4041, 4053, 4079, 4215, 4349, 4394, 4611, 5551], 'affect': [3856, 4587], 'levels,': [3859], '56': [3875], '74%,': [3877], 'respectively.': [3878], 'Knockdown': [3879, 4167, 5700], 'second': [3885, 3943], 'elicited': [3888], 'similar': [3889, 5512, 5590], 'Rb': [3894], '4C),': [3901], 'indicating': [3902], 'events': [3914], 'off-target': [3919], 'effects.': [3920, 5552], 'ensure': [3922], 'exclusive': [3928], 'line,': [3933, 3946], 'SK-MEL-28.': [3947], 'again': [3951], '4D).': [3957], 'overall': [3959], 'efficiency': [3960], 'lower': [3964], 'WM793;': [3970], '54': [3979], '39%,': [3981], 'respectively,': [3982], 'controls': [3986, 5020], '4E).': [3988], 'data': [3991, 4696, 5196, 5539, 5857], 'indicate': [3992, 5197, 5556], 'Contributes': [4010], 'Entry': [4013], 'Proliferation': [4015], 'Cells—To': [4018], 'entry,': [4027], 'measured': [4029], 'thymidine': [4033], 'analogue,': [4034], 'immunofluorescence.': [4044], 'dramatically': [4048, 4586], '5A).': [4055], 'Quantitation': [4056], '34%': [4059], 'siRNA-transfected': [4064], 'incorporated': [4067], '58%': [4071], 'Consistent': [4075], 'effects,': [4078], 'number': [4085], 'positively': [4089, 5067], 'marker': [4093], 'more': [4096, 5924], 'than': [4097, 4299, 5807, 5925], '50%': [4098], '5B)': [4100], 'numbers': [4104], '5C).': [4106], 'proliferation.': [4121, 5853], 'Does': [4162], 'Not': [4163], 'Rescue': [4164], 'Effects': [4168], 'A—We': [4171], 'One': [4206], 'possibility': [4207], 'reflect': [4216], 'certain': [4221], 'test': [4228], 'this,': [4229], 'coordinately': [4231], 'knocked': [4236, 4567], 'approach': [4245], 'transduce': [4248], 'epitope-tagged': [4253], 'As': [4257], 'controls,': [4258], 'non-transduced': [4259, 4289], 'lacZ-transduced': [4262], 'utilized.': [4265], 'blotting': [4267], 'identified': [4275], 'tagged': [4276], 'β-galactosidase': [4280], 'respective': [4283, 4461], '6A).': [4292], 'exogenous': [4294, 4326], 'migrated': [4297], 'slower': [4298, 5806], 'endogenous': [4301, 4318], 'comparable': [4315, 4358], 'Immunoprecipitation': [4321], 'functional': [4330], 'formed': [4334], '6B).': [4339], 'No': [4340], 'V5-β-galactosidase': [4346], 'immunoprecipitates.': [4347], 'led': [4353], 'efficient': [4356, 4673, 5495], 'non-transduced,': [4366], 'lacZ-transduced,': [4367], 'D1-transduced': [4370], '6C).': [4373], '2-fold': [4378], 'able': [4386, 5802], 'rescue': [4388, 5548], 'Differentially': [4404], 'Bind': [4405], 'CDKs—To': [4406], 'understand': [4407], 'how': [4408], 'contribute': [4415], 'CDKs,': [4427], 'co-immunoprecipitation.': [4433], 'whole': [4438], 'majority': [4448], '7A).': [4464], 'Immunoprecipitations': [4465], 'selective': [4467], 'since': [4468, 5732], 'immunoprecipitates': [4479, 4485, 4509], 'vice': [4481], 'versa': [4482], '7B).': [4487], 'Analysis': [4488], '7C).': [4511], 'lesser': [4521], 'extent': [4522, 5375], 'suggest': [4528], 'exhibit': [4535], 'associations': [4537], 'CDKs': [4539], 'bound': [4550], 'CDK6,': [4552, 5576], 'CDK6.': [4559], 'without': [4572], 'reducing': [4573], '(supplemental': [4577, 4591, 4605, 4620], '1A).': [4579], 'However,': [4580], '1A)': [4593], 'profile': [4598], 'propidium': [4602], 'iodide': [4603], '1B).': [4607], 'association': [4617], '1C).': [4622], 'finding': [4624, 5585, 5722], 'may': [4625, 4914, 4949, 5929], 'explain,': [4626], 'least': [4628, 5565], 'partially,': [4629], 'signaling.': [4665], 'even': [4683], 'though': [4684], 'also': [4688, 5336], 'Additionally,': [4694], 'preferred': [4708], 'partners.': [4711, 5720], 'supports': [4721], 'earlier': [4722], 'performed': [4724], 'sections': [4727], '29Bartkova': [4746, 4819], 'Zemanova': [4748, 4821], 'Int.': [4752, 4825], '65:': [4756, 4829, 4983], '323-327Crossref': [4757, 4830], '(65)': [4760, 4833], 'adds': [4764], 'growing': [4767], 'evidence': [4768, 5061], '30Russell': [4836], 'Thompson': [4838], 'Hendley': [4840], 'Trute': [4842], 'Armes': [4844], 'Germain': [4846], '18:': [4850], '1983-1991Crossref': [4851], '(115)': [4854], '31Zhang': [4857], 'Schofield': [4861], 'Sorensen': [4863], 'P.H.': [4864], 'Triche': [4865], 'T.J.': [4866], '64:': [4870, 5188], '6026-6034Crossref': [4871], '(56)': [4874], 'several': [4887], '(SBcl2': [4899], 'WM35)': [4901], 'do': [4903, 4927], '(SBcl2).': [4908], 'Hence,': [4909, 5048], 'up-regulation': [4910], 'be': [4915, 5204, 5930], 'event': [4918], 'alterations': [4937], 'molecular': [4943], 'weight': [4944], 'forms': [4945, 5413], 'E': [4948], 'play': [4950, 5848], 'key': [4952], '(32Bales': [4954], 'Milam': [4958], 'McGahren-Murray': [4960], 'Bandyopadhyay': [4962], 'Chen': [4964], 'Reed': [4966, 5772], 'J.A.': [4967, 5149], 'Timchenko': [4968], 'den': [4971], 'Oord': [4972], 'Bar-Eli': [4974], 'Keyomarsi': [4976], 'Medrano': [4978], 'E.E.': [4979], '692-697PubMed': [4984], 'require': [5000], 'contrasts': [5005], 'showing': [5016], 'manner': [5027], 'Recent': [5057], 'provided': [5060], 'regulating': [5068], 'development': [5071], '33Dhawan': [5091], 'Singh': [5093], 'A.B.': [5094], 'Richmond': [5097], '7335-7342PubMed': [5103], '34Li': [5106], 'Kalabis': [5108], 'Xu': [5110], 'Meier': [5112], 'Oka': [5114], 'Bogenrieder': [5116], '22:': [5122], '6891-6899Crossref': [5123], '(68)': [5126], '35Dai': [5129], 'Martinka': [5131], 'Oncol.': [5137], '1473-1482Crossref': [5140], '(251)': [5143], '36Jetzt': [5146], 'Howe': [5148], 'Horn': [5150], 'Maxwell': [5152], 'Yin': [5154], 'Z.': [5155], 'Johnson': [5156], 'Kumar': [5158], 'C.C.': [5159], '6697-6706PubMed': [5164], '37Stahl': [5167], 'Zimmerman': [5173], 'Cheng': [5175], 'J.Q.': [5176], 'Bosenberg': [5177], 'M.W.': [5178], 'Kester': [5179], 'Sandirasegarane': [5181], '7002-7010Crossref': [5189], '(464)': [5192], 'Our': [5195], 'target': [5207], 'melanoma.': [5213], 'has': [5217], 'been': [5218], '(25Naderi': [5302], 'initial': [5325], 'mTOR': [5333], 'rapamycin': [5335], 'Evidence': [5347], 'adhesion-PI-3': [5350], 'kinase-cyclin': [5351], 'primarily': [5355], 'supported': [5362], 'additional': [5366], 'WM278.': [5373], 'non-redundant': [5381, 5567], 'functions': [5382], 'issue.': [5386], 'Deficiency': [5387], 'individual': [5389], 'reduces': [5392], 'susceptibility': [5393], 'mediated': [5396], 'oncogenes.': [5399], 'Loss': [5400], 'alone': [5404], 'protective': [5406], 'against': [5407, 5441], 'breast': [5408, 5743], 'induced': [5410, 5443], 'oncogenic': [5412], 'Ras': [5415], 'Neu': [5417], '(38Yu': [5418], '411:': [5426], '1017-1021Crossref': [5427], '(833)': [5430], 'Scholar);': [5432, 5839], 'deficiency': [5435], 'hematopoietic': [5437], 'progenitor': [5438], 'protects': [5440], 'active': [5445], 'Notch1': [5446], 'necessary': [5493, 5931], 'cells;': [5504], 'notably': [5505], 'Also,': [5537], 'Combined,': [5553], 'serve': [5563], 'associates': [5580], 'CDK4.': [5582], 'former': [5584], 'phenotypes': [5591], 'CDK6-/-': [5594], 'D3-/-': [5597], '39Malumbres': [5638], 'Sotillo': [5640, 5812], 'Santamaria': [5642, 5814], 'Galan': [5644, 5816], 'Cerezo': [5646, 5818], 'Ortega': [5648, 5820], 'Dubus': [5650, 5822], 'Barbacid': [5652, 5824], '118:': [5656, 5828], '493-504Abstract': [5657, 5829], '(631)': [5665, 5837], 'Interestingly,': [5668], 'CDK6-cyclin': [5669], 'resistance': [5674], 'inhibition': [5676], 'p16INK4a': [5678], '(40Faast': [5679], 'White': [5681], 'Cartwright': [5683], 'Crocker': [5685], 'Sarcevic': [5687], 'Dalton': [5689], '491-502Crossref': [5694], '(98)': [5697], 'inhibit': [5705], 'possibly': [5709], 'redistribution': [5713], 'surprising': [5731], 'D1-CDK2': [5740], '(41Sweeney': [5746], 'K.J.': [5747], 'Swarbrick': [5748], 'Sutherland': [5750], 'Musgrove': [5752], 'E.A.': [5753], '16:': [5756], '2865-2878Crossref': [5757], '(72)': [5760], 'senescent': [5764], 'fibroblasts': [5765, 5794], '(42Dulic': [5766], 'Drullinger': [5768], 'L.F.': [5769], 'Lees': [5770], 'S.I.': [5773], 'Stein': [5774], 'G.H.': [5775], 'Proc.': [5776], 'Acad.': [5778], 'Sci.': [5779], 'U.': [5780], '1993;': [5783], '90:': [5784], '11034-11038Crossref': [5785], '(287)': [5788], 'Furthermore,': [5791], 'mouse': [5792], 'embryo': [5793], 'deficient': [5795], 'proliferate,': [5804], 'albeit': [5805], 'counterparts': [5809], '(39Malumbres': [5810], 'hence,': [5840], 'possible': [5843], 'D-CDK2': [5846], 'summary,': [5855], 'together': [5871], '43Rieber': [5905], 'Rieber': [5907], 'Death': [5910], 'Differ.': [5911], '1209-1215Crossref': [5914], '(10)': [5917], 'highlight': [5920], 'therapeutic': [5921], 'one': [5926], 'block': [5934], 'growth.': [5936], 'indebted': [5939], 'staff': [5942], 'providing': [5952], 'discarded': [5953], 'samples': [5955], 'melanocyte': [5957], 'isolation.': [5958], 'very': [5961], 'grateful': [5962], 'Philadelphia,': [5969], 'PA)': [5970], 'lines,': [5981], 'Jihe': [5983], 'cDNA,': [5988], 'Michael': [5991], 'DiPersio': [5992], 'critically': [5994], 'manuscript.': [5997], 'Download': [5998], '.zip': [5999], '(.1': [6000], 'MB)': [6001], 'Help': [6002], 'zip': [6004], 'files': [6005]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2050984994', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 5}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2025-01-21T04:24:04.359680', 'created_date': '2016-06-24'}
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