Publication Information

{'id': 'https://openalex.org/W2050696207', 'doi': 'https://doi.org/10.1074/jbc.m704343200', 'title': 'PRR5, a Novel Component of mTOR Complex 2, Regulates Platelet-derived Growth Factor Receptor β Expression and Signaling', 'display_name': 'PRR5, a Novel Component of mTOR Complex 2, Regulates Platelet-derived Growth Factor Receptor β Expression and Signaling', 'publication_year': 2007, 'publication_date': '2007-06-29', 'ids': {'openalex': 'https://openalex.org/W2050696207', 'doi': 'https://doi.org/10.1074/jbc.m704343200', 'mag': '2050696207', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/17599906'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m704343200', 'pdf_url': 'http://www.jbc.org/article/S0021925820746351/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 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Hegg', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I130238516', 'display_name': 'University of Minnesota', 'ror': 'https://ror.org/017zqws13', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I130238516']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'James W. 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['https://openalex.org/W3200561857', 'https://openalex.org/W3021526079', 'https://openalex.org/W3018246728', 'https://openalex.org/W2946335957', 'https://openalex.org/W2325585628', 'https://openalex.org/W2088207925', 'https://openalex.org/W2054117275', 'https://openalex.org/W2008913806', 'https://openalex.org/W1977883755', 'https://openalex.org/W1566520694'], 'abstract_inverted_index': {'The': [0, 218, 282, 500, 2138, 2163, 2397, 3111, 3154, 3319, 3488, 4308], 'protein': [1, 39, 68, 94, 97, 283, 321, 350, 376, 379, 623, 770, 922, 985, 1156, 1344, 1569, 1728, 2942, 3121, 3476, 3748], 'kinase': [2, 284, 649, 1570], 'mammalian': [3, 285, 909, 1692, 2418, 3270], 'target': [4, 286, 614, 910, 2776], 'of': [5, 16, 56, 72, 85, 89, 153, 170, 189, 220, 236, 248, 267, 287, 298, 338, 354, 367, 371, 435, 452, 471, 502, 518, 530, 549, 570, 590, 615, 624, 627, 645, 671, 764, 911, 923, 927, 956, 974, 1150, 1155, 1331, 1446, 1558, 1694, 1723, 1782, 1995, 2033, 2037, 2343, 2361, 2377, 2389, 2792, 2842, 2886, 2921, 2939, 2958, 3015, 3020, 3058, 3061, 3066, 3183, 3216, 3375, 3385, 3415, 3425, 3453, 3529, 3652, 3741, 3749, 3785, 3794, 3821, 3831, 3836, 3867, 3885, 3905, 3912, 4036, 4060, 4067, 4158, 4208, 4257, 4311, 4337, 4355], 'rapamycin': [6, 288, 912], '(mTOR)': [7, 289], 'plays': [8, 290, 752], 'an': [9, 291, 1730, 1861, 2233, 2734, 2961, 2969, 3124, 3416, 3478, 3486, 3746, 4071], 'important': [10, 174, 292, 456, 1800, 3901, 3919, 4048, 4163, 4302, 4333, 4345], 'role': [11, 266, 293, 548, 755, 3126, 3830], 'in': [12, 59, 213, 232, 269, 294, 341, 495, 514, 551, 578, 603, 658, 666, 756, 791, 965, 990, 1232, 1469, 1733, 1883, 1948, 2001, 2031, 2132, 2212, 2220, 2252, 2404, 2466, 2571, 2586, 2631, 2637, 2672, 2694, 2789, 2901, 3078, 3083, 3127, 3227, 3292, 3295, 3408, 3412, 3422, 3430, 3451, 3458, 3567, 3576, 3591, 3604, 3607, 3695, 3762, 3769, 3833, 3855, 3872, 3882, 3889, 3894, 4033, 4090, 4201, 4217, 4280], 'the': [13, 53, 57, 67, 149, 162, 176, 233, 270, 273, 295, 335, 339, 349, 431, 444, 458, 515, 552, 555, 591, 646, 659, 757, 1168, 1676, 1710, 1772, 1777, 1792, 1865, 2113, 2119, 2123, 2130, 2199, 2204, 2346, 2375, 2424, 2467, 2609, 2679, 2769, 2781, 2790, 2825, 2876, 2890, 2972, 3018, 3051, 3286, 3333, 3353, 3373, 3386, 3397, 3413, 3423, 3426, 3440, 3482, 3507, 3703, 3786, 3834, 3837, 3842, 3865, 3883, 3903, 3921, 4034, 4037, 4050, 4065, 4068, 4080, 4085, 4104, 4110, 4115, 4165, 4189, 4206, 4254, 4295, 4315, 4327, 4335, 4359], 'coordinate': [14, 296], 'regulation': [15, 297, 569, 593], 'cellular': [17, 274, 299, 556, 575, 672, 765], 'responses': [18, 300], 'to': [19, 35, 51, 66, 75, 301, 317, 333, 348, 357, 580, 596, 668, 983, 992, 1167, 1709, 1807, 1848, 1945, 2172, 2193, 2203, 2336, 2658, 2798, 2875, 2982, 3025, 3178, 3252, 3468, 3493, 3800, 3847, 3878, 3917, 4030, 4109, 4364], 'nutritional': [20, 61, 302, 343], 'and': [21, 33, 42, 62, 111, 133, 148, 155, 179, 199, 202, 216, 222, 250, 258, 280, 303, 315, 324, 344, 393, 415, 430, 437, 461, 481, 484, 498, 504, 532, 540, 562, 586, 680, 773, 784, 960, 970, 978, 980, 987, 995, 1159, 1161, 1164, 1335, 1337, 1452, 1456, 1461, 1555, 1577, 1682, 1684, 1696, 1771, 1780, 1787, 1795, 1804, 1809, 1812, 1832, 1860, 1878, 1927, 1967, 1971, 2035, 2099, 2116, 2156, 2178, 2196, 2214, 2224, 2334, 2352, 2359, 2370, 2383, 2399, 2408, 2415, 2422, 2458, 2558, 2564, 2581, 2628, 2651, 2663, 2676, 2714, 2727, 2753, 2775, 2831, 2899, 2979, 3022, 3028, 3171, 3245, 3257, 3264, 3298, 3340, 3344, 3372, 3402, 3445, 3569, 3580, 3596, 3622, 3630, 3655, 3764, 3863, 4041, 4100, 4156, 4160, 4171, 4183, 4194, 4204, 4211, 4224, 4229, 4236, 4244, 4260, 4264, 4269, 4287, 4306, 4349, 4357], 'growth': [22, 63, 215, 238, 256, 304, 345, 497, 520, 538, 565, 583, 617, 620, 665, 678, 914, 918, 989, 996, 1170, 1816, 1968, 3297], 'factor': [23, 64, 239, 305, 346, 521, 584, 618, 621, 915, 919, 997, 1817], 'conditions.': [24, 306], 'mTOR': [25, 154, 180, 307, 436, 462, 751, 792, 924, 928, 929, 932, 958, 963, 2040, 2106, 2980, 3079, 3360, 3365, 3401, 3409, 3417, 3444, 3448, 3503, 3644, 3754, 3763, 3826, 3848, 3871, 3873, 3890, 4040, 4159, 4182, 4193, 4210, 4228, 4235, 4263, 4286, 4305, 4348], 'achieves': [26, 308], 'these': [27, 309, 3635], 'roles': [28, 55, 212, 310, 337, 494], 'through': [29, 311, 3858], 'interacting': [30, 312, 3747], 'with': [31, 143, 210, 230, 272, 313, 425, 492, 512, 554, 789, 1766, 1857, 2029, 2112, 2118, 2142, 2158, 2168, 2208, 2340, 2596, 2644, 2653, 2678, 2716, 2748, 2780, 2814, 2835, 2933, 2952, 3239, 3285, 3328, 3363, 3439, 3501, 3660, 3823, 3870, 4056, 4181, 4192, 4214, 4227, 4240, 4248, 4262, 4314, 4329], 'raptor': [32, 314, 3770], 'rictor': [34, 316, 1788, 2400, 3765, 3801, 3822, 3832, 3854, 3899, 4154, 4161, 4195, 4212, 4237, 4288, 4330], 'form': [36, 318, 3384], 'two': [37, 319, 966, 1153, 1457, 3266], 'distinct': [38, 320], 'complexes,': [40, 322, 968], 'mTORC1': [41, 50, 323, 332, 969, 972, 1147, 1223, 1352], 'mTORC2.': [43, 325, 971], 'Previous': [44, 326], 'studies': [45, 327, 1564], 'have': [46, 77, 328, 359, 953, 1465, 1688, 2469, 3272], 'been': [47, 329, 652, 1467, 2470, 3274, 3534, 3915], 'focused': [48, 330], 'on': [49, 103, 191, 331, 385, 473, 567, 599, 2232, 2848, 3012, 3034, 3159], 'elucidate': [52, 334], 'central': [54, 336, 656, 754], 'complex': [58, 340, 629, 631, 930, 933, 1677, 3755, 3788], 'mediating': [60, 342], 'signals': [65, 347, 673, 998, 1166], 'synthesis': [69, 351, 986, 2893], 'machinery.': [70, 352], 'Functions': [71, 353, 1554], 'mTORC2,': [73, 171, 355, 453, 3913], 'relative': [74, 356], 'mTORC1,': [76, 358], 'remained': [78, 360], 'little': [79, 361, 3650], 'understood.': [80, 362], 'Here': [81, 363], 'we': [82, 364, 1687, 1698, 1718, 1999, 2967, 3054, 3510, 3637, 3751, 3851, 4185, 4231, 4351], 'report': [83, 365, 1886], 'identification': [84, 366], 'a': [86, 96, 100, 104, 207, 264, 368, 378, 382, 386, 489, 546, 643, 655, 669, 753, 762, 1720, 1727, 1869, 2073, 2133, 2143, 2174, 2181, 2284, 2330, 2341, 2390, 2659, 2740, 2849, 2928, 2934, 2947, 2953, 3064, 3119, 3162, 3213, 3289, 3329, 3381, 3657, 3698, 3739, 3782, 3791, 3818, 3829, 3859, 3879, 4031, 4091], 'novel': [87, 369, 1721], 'component': [88, 169, 370, 451, 1722, 3911], 'mTORC2': [90, 268, 372, 550, 1329, 1349, 1559, 1567, 1713, 1724, 3777], 'named': [91, 373, 1725], 'PRR5': [92, 141, 190, 195, 211, 226, 243, 374, 423, 472, 477, 493, 508, 525, 1763, 1786, 1798, 1850, 1855, 1947, 2398, 2624, 2738, 2959, 3155, 3174, 3235, 3279, 3378, 3404, 3455, 3470, 3474, 3497, 3514, 3531, 3562, 3601, 3640, 3690, 3706, 3737, 3744, 3759, 3774, 3796, 3824, 3845, 3868, 3886, 3906, 4025, 4045, 4061, 4152, 4168, 4179, 4312, 4356], '(PRoline-Rich': [93, 375], '5),': [95, 377], 'encoded': [98, 380], 'by': [99, 225, 381, 507, 1226, 2226, 2366, 2387, 2412, 2428, 2434, 2642, 2756, 2867, 2908, 3393, 3518, 3643, 4074], 'gene': [101, 383, 3156], 'located': [102, 384, 3158], 'chromosomal': [105, 387], 'region': [106, 388, 3163, 3331, 4310], 'frequently': [107, 389, 3166], 'deleted': [108, 390, 3167], 'during': [109, 391, 3168, 4334], 'breast': [110, 392, 3170, 3624], 'colorectal': [112, 394, 3172], 'carcinogenesis': [113, 395], '(Johnstone,': [114, 396], 'C.': [115, 397, 1073, 2368], 'N.,': [116, 398], 'Castellvi-Bel,': [117, 399], 'S.,': [118, 400], 'Chang,': [119, 401], 'L.': [120, 402, 897], 'M.,': [121, 130, 403, 412], 'Sung,': [122, 404], 'R.': [123, 405, 1093, 1354, 1420, 1473, 1508, 1616, 2317], 'K.,': [124, 406], 'Bowser,': [125, 407], 'M.': [126, 408, 714, 846, 850, 852, 1658], 'J.,': [127, 409], 'Pique,': [128, 410], 'J.': [129, 411, 860, 1075, 1242, 1263, 1313, 1513, 1536, 1659, 2297, 3990], 'Castells,': [131, 413], 'A.,': [132, 414], 'Rustgi,': [134, 416], 'A.': [135, 417, 688, 712, 1099, 1177, 1214, 1360, 1422, 1428, 1479, 1532, 1618, 1624, 1748, 2311, 2372, 3142, 3199, 3550, 3678, 3725], 'K.': [136, 418, 824, 891, 1061, 1067, 1077, 1236, 1311, 4007], '(2005)': [137, 419], 'Genomics': [138, 420], '85,': [139, 421], '338–351).': [140, 422], 'interacts': [142, 424, 1765, 3362, 4180], 'rictor,': [144, 426, 1333, 1767, 3850, 4042, 4184, 4230, 4265, 4350], 'but': [145, 252, 427, 534, 1768, 3081, 3247, 3420, 3456, 3521, 3767, 3892, 4083, 4246, 4271], 'not': [146, 156, 173, 428, 438, 455, 1340, 1466, 1689, 1769, 3082, 3249, 3273, 3421, 3457, 3522, 3768, 3887, 4028, 4047, 4063, 4084, 4247, 4272], 'raptor,': [147, 429, 976, 1770], 'interaction': [150, 178, 432, 460, 1773, 1779, 1794, 3399, 3442, 3923, 4038, 4052, 4072, 4106, 4117, 4256, 4328], 'is': [151, 172, 433, 454, 1224, 1774, 1799, 3157, 3165, 3225, 3499, 3515, 3564, 3572, 3602, 3641, 3691, 3709, 3745, 3900, 4046, 4107, 4162, 4331], 'independent': [152, 434, 1781], 'disturbed': [157, 439], 'under': [158, 440, 2804, 3047], 'conditions': [159, 441, 3041], 'that': [160, 276, 442, 558, 573, 662, 760, 1566, 1686, 1700, 1762, 1797, 1998, 2328, 2736, 3030, 3071, 3122, 3164, 3233, 3359, 3498, 3512, 3600, 3639, 3743, 3773, 3781, 3817, 3844, 3898, 4044, 4103, 4113, 4151, 4178, 4221, 4233, 4294, 4326], 'disrupt': [161, 443], 'mTOR-rictor': [163, 177, 445, 459, 3787, 3922, 4069, 4116], 'interaction.': [164, 446, 3839, 4167], 'PRR5,': [165, 447, 1726, 3118, 3211, 3364, 3403, 3446, 3790], 'unlike': [166, 448], 'Sin1,': [167, 449, 1336, 3909], 'another': [168, 450, 3910], 'for': [175, 457, 1791, 1801, 2355, 2442, 2618, 2648, 2705, 2806, 2895, 3042, 3068, 3902, 3920, 4049, 4164, 4175, 4303, 4342, 4346, 4361], 'activity': [181, 463], 'toward': [182, 464], 'Akt': [183, 193, 198, 221, 251, 465, 475, 480, 503, 533, 633, 936, 1578, 1683, 1808, 1917], 'phosphorylation.': [184, 260, 466, 542], 'Despite': [185, 467], 'no': [186, 468], 'significant': [187, 469, 3880], 'effect': [188, 470], 'mTORC2-mediated': [192, 474], 'phosphorylation,': [194, 476, 1573], 'silencing': [196, 244, 478, 526, 3876, 4026], 'inhibits': [197, 479], 'S6K1': [200, 223, 249, 482, 505, 531, 1158, 1911], 'phosphorylation': [201, 224, 247, 483, 506, 529, 1579], 'reduces': [203, 254, 485, 536], 'cell': [204, 214, 486, 496, 600, 604, 664, 988, 1169, 2567, 2844, 3610, 3619, 3626, 3699, 3895], 'proliferation': [205, 487], 'rates,': [206, 488], 'result': [208, 490, 3658], 'consistent': [209, 491, 3659], 'tumorigenesis.': [217, 499], 'inhibition': [219, 501], 'knock': [227, 509], 'down': [228, 510, 3495, 3853, 4284], 'correlates': [229, 511], 'reduction': [231, 513, 3881], 'expression': [234, 279, 516, 561, 1803, 2385, 2419], 'level': [235, 517, 3708], 'platelet-derived': [237, 519, 913], 'receptor': [240, 522, 916, 920, 1818, 1929], 'β': [241, 523, 1930], '(PDGFRβ).': [242, 524], 'impairs': [245, 527], 'PDGF-stimulated': [246, 528], 'moderately': [253, 535], 'epidermal': [255, 537, 917, 1815], 'factor-': [257, 539], 'insulin-stimulated': [259, 541], 'These': [261, 543, 4148, 4291], 'findings': [262, 544], 'propose': [263, 545], 'potential': [265, 547], 'cross-talk': [271, 553], 'machinery': [275, 557, 1171], 'regulates': [277, 559, 663, 761, 1148, 1568], 'PDGFRβ': [278, 560, 1802, 2923], 'signaling.': [281, 563, 1714], 'Cell': [564, 811, 1137, 1246, 1294, 1432, 1628, 1899, 1935, 2017, 2062, 2268, 2546, 2556, 2729, 2809, 2998, 3101, 3936], 'relies': [566], 'coordinated': [568, 592], 'signaling': [571, 660, 758, 793, 1234, 1806], 'pathways': [572], 'integrate': [574], 'physiological': [576], 'status': [577], 'response': [579, 667, 991], 'nutrient': [581, 676, 993, 1163], 'levels,': [582, 677], 'signals,': [585], 'environmental': [587, 681], 'stress.': [588], 'Impairment': [589], 'can': [594], 'lead': [595, 4029], 'disastrous': [597], 'effects': [598], 'physiology,': [601], 'resulting': [602], 'death': [605], 'or': [606, 2599, 2685, 2739, 2802, 3429, 3477], 'uncontrolled': [607], 'growth.': [608], 'mTOR,': [609, 975, 1332, 1680, 3750], '2The': [610], 'abbreviations': [611], 'used': [612, 1944, 2028, 2403, 2441, 2465], 'are:mTORmammalian': [613], 'rapamycinPDGFRplatelet-derived': [616], 'receptorEGFRepidermal': [619], 'receptorraptorregulatory-associated': [622], 'mTORrictorrapamycin-insensitive': [625], 'companion': [626, 926], 'mTORmTORC1mTOR': [628], '1mTORC2mTOR': [630], '2PRAS40proline-rich': [632], 'substrate': [634, 937], '40': [635, 938, 2077], 'kDaGSTglutathione': [636], 'S-transferaseHEKhuman': [637], 'embryonic': [638, 943], 'kidneyHAhemagglutininChaps3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonic': [639], 'acidshRNAshort': [640], 'hairpin': [641, 949], 'RNA.': [642, 950], 'member': [644], 'phosphatidylinositol': [647], 'kinase-related': [648], 'family,': [650], 'has': [651, 3123, 3914], 'known': [653], 'as': [654, 780, 2047, 2250, 2960, 3045, 3180, 3260, 3262, 3485, 3613, 4276], 'player': [657], 'pathway': [661], 'variety': [670, 763], 'derived': [674, 3116, 3701], 'from': [675, 1351, 1838, 1872, 1934, 1952, 1961, 1975, 1985, 1991, 2044, 2129, 2198, 2768, 2863, 2883, 3074, 3117, 3241, 3254, 3369, 3702], 'factors,': [679], 'stress': [682], '(2Brunn': [683, 1172], 'G.J.': [684, 1173], 'Hudson': [685, 1174], 'C.C.': [686, 1175, 3949], 'Sekulic': [687, 1176], 'Williams': [689, 1178], 'J.M.': [690, 1179, 1540, 1746, 3140, 3197, 3548, 3676, 3723], 'Hosoi': [691, 1180], 'H.': [692, 873, 1010, 1040, 1181, 1397, 1593, 2484, 2514, 4129], 'Houghton': [693, 1182], 'P.J.': [694, 1183], 'Lawrence': [695, 1184], 'Jr.,': [696, 1185], 'J.C.': [697, 1186], 'Abraham': [698, 1187], 'R.R.': [699, 1008, 1036, 1188, 1395, 1591, 2482, 2510, 4127], 'Science.': [700, 721, 1189, 1646], '1997;': [701, 1190], '277:': [702, 1191], '99-101Crossref': [703, 1192], 'PubMed': [704, 725, 746, 816, 836, 867, 883, 904, 1024, 1055, 1087, 1120, 1142, 1193, 1218, 1251, 1276, 1299, 1324, 1381, 1412, 1437, 1500, 1524, 1549, 1608, 1633, 1650, 1670, 1755, 1904, 2022, 2067, 2273, 2305, 2323, 2498, 2529, 2551, 3003, 3106, 3149, 3206, 3314, 3557, 3685, 3732, 3941, 3970, 4017, 4143], 'Scopus': [705, 726, 747, 817, 837, 868, 884, 905, 1025, 1056, 1088, 1121, 1143, 1194, 1219, 1252, 1277, 1300, 1325, 1382, 1413, 1438, 1501, 1525, 1550, 1609, 1634, 1651, 1671, 1756, 1905, 2023, 2068, 2274, 2306, 2324, 2499, 2530, 2552, 3004, 3107, 3150, 3207, 3315, 3558, 3686, 3733, 3942, 3971, 4018, 4144], '(814)': [706, 1195], 'Google': [707, 728, 749, 819, 839, 870, 886, 907, 1027, 1058, 1090, 1123, 1145, 1196, 1221, 1254, 1279, 1302, 1327, 1384, 1415, 1440, 1503, 1527, 1552, 1611, 1636, 1653, 1673, 1758, 1907, 2025, 2070, 2276, 2308, 2326, 2501, 2532, 2554, 3006, 3109, 3152, 3209, 3317, 3560, 3688, 3735, 3944, 3973, 4002, 4020, 4146], 'Scholar,': [708, 729, 820, 840, 871, 887, 1028, 1059, 1091, 1124, 1197, 1255, 1280, 1303, 1385, 1416, 1504, 1528, 1612, 1637, 1654, 2309, 2502, 2533, 3945, 3974, 4003], '3Dennis': [709], 'P.B.': [710], 'Jaeschke': [711], 'Saitoh': [713], 'Fowler': [715], 'B.': [716, 807, 1288, 3992], 'Kozma': [717, 857], 'S.C.': [718, 858], 'Thomas': [719, 861], 'G.': [720, 862, 3307], '2001;': [722], '294:': [723], '1102-1105Crossref': [724], '(807)': [727], '4Shimji': [730], 'A.F.': [731], 'Nghiem': [732], 'P.': [733, 799, 1012, 1042, 1107, 1368, 1399, 1487, 1595, 2486, 2516, 4131], 'Schreiber': [734], 'S.L.': [735], 'Mol.': [736, 1045, 1110, 1266, 1371, 1490, 1543, 2519], 'Cell.': [737, 1015, 1046, 1078, 1111, 1267, 1372, 1491, 1545, 2489, 2520, 3993, 4134], '2003;': [738, 901, 1047, 1296, 1546, 2521], '12:': [739], '271-280Abstract': [740], 'Full': [741, 743, 1019, 1021, 1050, 1052, 1082, 1084, 1115, 1117, 1271, 1273, 1319, 1321, 1376, 1378, 1407, 1409, 1495, 1497, 1519, 1521, 1603, 1605, 1665, 1667, 2493, 2495, 2524, 2526, 3965, 3967, 3997, 3999, 4138, 4140], 'Text': [742, 744, 1020, 1022, 1051, 1053, 1083, 1085, 1116, 1118, 1272, 1274, 1320, 1322, 1377, 1379, 1408, 1410, 1496, 1498, 1520, 1522, 1604, 1606, 1666, 1668, 2494, 2496, 2525, 2527, 3966, 3968, 3998, 4000, 4139, 4141], 'PDF': [745, 1023, 1054, 1086, 1119, 1275, 1323, 1380, 1411, 1499, 1523, 1607, 1669, 2497, 2528, 3969, 4001, 4142], '(176)': [748], 'Scholar).': [750, 908, 1146, 1222, 1328, 1441, 1553, 1674, 1759, 1908, 2277, 2555, 3007, 3110, 3153, 3210, 3318, 3561, 3689, 3736, 4021, 4147], 'network': [759], 'processes': [766], 'including': [767, 3593], 'ribosome': [768], 'biogenesis,': [769], 'synthesis,': [771, 1157], 'autophagy,': [772], 'actin': [774, 1574], 'cytoskeleton': [775, 1575], 'organization;': [776], 'human': [777, 942, 1849, 2362, 2922, 3169, 3234, 3469, 3530, 3609, 3617, 3623], 'diseases': [778], 'such': [779, 3612], 'cancer,': [781], 'diabetes,': [782], 'obesity,': [783], 'harmatoma': [785], 'syndrome': [786], 'are': [787, 3342, 4238], 'associated': [788, 3500, 3869], 'defects': [790], '(5Gao': [794], 'X.': [795, 1065, 1284, 1305], 'Zhang': [796, 892], 'Y.': [797, 893, 1063, 1238, 1282, 1307], 'Arrazola': [798], 'Hino': [800], 'O.': [801], 'Kobayashi': [802], 'T.': [803, 889, 1240, 1542, 3955, 4009], 'Yeung': [804, 876], 'R.S.': [805, 877], 'Ru': [806, 1287], 'Pan': [808, 1291], 'D.': [809, 1103, 1292, 1364, 1483, 3980], 'Nat.': [810, 1136, 1245, 1293, 1898, 2016, 2061, 2267, 2545, 2997, 3100, 3935], 'Biol.': [812, 1138, 1247, 1295, 1315, 1403, 1433, 1514, 1544, 1599, 1629, 1660, 1900, 2018, 2063, 2269, 2547, 2999, 3102, 3310, 3937, 3961], '2002;': [813, 1016, 1079, 1112, 1248, 1268, 1373, 1492, 2320, 2490, 4135], '4:': [814, 1249], '699-704Crossref': [815], '(577)': [818], '6Corradetti': [821], 'M.N.': [822, 1109, 1261, 1370, 1430, 1489, 1512, 1626], 'Inoki': [823, 4006], 'Bardeesy': [825], 'N.': [826, 1069, 3305, 3982], 'Depinho': [827], 'R.A.': [828], 'Guan': [829, 1243, 4010], 'K.L.': [830, 1244, 4011], 'Genes': [831, 4012], 'Dev.': [832, 4013], '2004;': [833, 864, 1404, 1434, 1600, 1630, 3311], '18:': [834], '1533-1538Crossref': [835], '(470)': [838], '7Um': [841], 'S.H.': [842, 1205], 'Frigerio': [843], 'F.': [844, 848, 899], 'Watanabe': [845], 'Picard': [847], 'Joaquin': [849], 'Sticker': [851], 'Fumagalli': [853], 'S.': [854, 1071, 1097, 1131, 1213, 1309, 1358, 1424, 1477, 1506, 1534, 1620, 1738, 1893, 2011, 2056, 2262, 2436, 2540, 2758, 2992, 3095, 3132, 3189, 3303, 3540, 3668, 3715, 3930, 3984], 'Allegrini': [855], 'P.R.': [856], 'Auwerx': [859], 'Nature.': [863, 900], '431:': [865], '200-205Crossref': [866], '(1376)': [869], '8Kenerson': [872], 'Dundon': [874], 'T.A.': [875], 'Pediatr.': [878], 'Res.': [879], '2005;': [880, 1316, 1516, 1647, 1662, 1752, 3146, 3203, 3554, 3682, 3729], '57:': [881], '67-75Crossref': [882], '(130)': [885], '9Vellai': [888], 'Takacs-Vellai': [890], 'Kovacs': [894], 'A.L.': [895, 2294], 'Orosz': [896], 'Muller': [898], '426:': [902], '620Crossref': [903], '(847)': [906], 'regulatory-associated': [921], 'rapamycin-insensitive': [925], '1': [931, 2085, 2335, 2344, 2918, 3351, 3654, 4223, 4243, 4259, 4268], '2': [934, 2615, 3339, 4225, 4261], 'proline-rich': [935, 3120, 3330], 'kDa': [939], 'glutathione': [940, 1858], 'S-transferase': [941, 1859], 'kidney': [944, 3568, 3704], 'hemagglutinin': [945], '3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonic': [946], 'acid': [947, 2171, 2223], 'short': [948], 'Recent': [951, 1563], 'years': [952], 'seen': [954], 'discoveries': [955], 'several': [957, 2807, 3181, 3608], 'effectors': [959], 'binding': [961, 3846, 4304, 4347], 'proteins.': [962], 'exists': [964], 'multiprotein': [967], 'consists': [973, 1330, 1445], 'GβL,': [977, 1334], 'PRAS40,': [979], 'it': [981, 1338], 'functions': [982], 'regulate': [984], 'levels': [994, 3812], '(10Kim': [999, 2473, 4118], 'D-H.': [1000, 1030, 1391, 1587, 2474, 2504, 4119], 'Sarbassov': [1001, 1031, 2475, 2505, 4120], 'D.D.': [1002, 1032, 1387, 1583, 1639, 2476, 2506, 4121], 'Ali': [1003, 1033, 1388, 1584, 1642, 2477, 2507, 4122], 'S.M.': [1004, 1034, 1389, 1585, 1643, 2478, 2508, 4123], 'King': [1005, 2479, 4124], 'J.E.': [1006, 2480, 4125], 'Latek': [1007, 1035, 1394, 1590, 2481, 2509, 4126], 'Erdjument-Bromage': [1009, 1039, 1396, 1592, 2483, 2513, 4128], 'Tempst': [1011, 1041, 1398, 1594, 2485, 2515, 4130], 'Sabatini': [1013, 1043, 1206, 1400, 1596, 1644, 2487, 2517, 3958, 4132], 'D.M.': [1014, 1044, 1207, 1401, 1597, 1645, 2488, 2518, 3959, 4133], '110:': [1017, 1080, 2491, 4136], '163-175Abstract': [1018, 2492, 4137], '(2391)': [1026, 2500, 4145], '11Kim': [1029, 2503], 'Kalyani': [1037, 2511], 'V.P.': [1038, 2512], '11:': [1048, 2522], '895-904Abstract': [1049, 2523], '(774)': [1057, 2531], '12Hara': [1060], 'Maruki': [1062], 'Long': [1064], 'Yoshino': [1066], 'Oshiro': [1068], 'Hidayat': [1070], 'Tokunaga': [1072], 'Avruch': [1074, 1312], 'Yonezawa': [1076, 1310], '177-189Abstract': [1081], '(1458)': [1089], '13Loewith': [1092], 'Jacinto': [1094, 1355, 1474], 'E.': [1095, 1127, 1356, 1418, 1475, 1614, 1889, 2007, 2052, 2258, 2315, 2536, 2988, 3091, 3926, 3976], 'Wullschleger': [1096, 1357, 1476], 'Lorberg': [1098, 1359, 1478], 'Crespo': [1100, 1361, 1480], 'J.L.': [1101, 1362, 1481], 'Bonenfant': [1102, 1363, 1482], 'Oppliger': [1104, 1365, 1484, 1509], 'W.': [1105, 1366, 1485, 1510, 3953], 'Jenoe': [1106, 1367, 1486], 'Hall': [1108, 1369, 1427, 1429, 1488, 1511, 1623, 1625], '10:': [1113, 1269, 1374, 1493], '457Abstract': [1114, 1375, 1494], '(1484)': [1122, 1383, 1502], '14Vander': [1125, 2534], 'Haar': [1126, 1888, 2006, 2051, 2257, 2535, 2987, 3090, 3925], 'Lee': [1128, 1890, 2008, 2053, 2259, 2537, 2989, 3092, 3927], 'S-I.': [1129, 1891, 2009, 2054, 2260, 2538, 2990, 3093, 3928], 'Bandhakavi': [1130, 1892, 2010, 2055, 2261, 2539, 2991, 3094, 3929], 'Griffin': [1132, 1894, 2012, 2057, 2263, 2541, 2993, 3096, 3931], 'T.J.': [1133, 1895, 2013, 2058, 2264, 2542, 2994, 3097, 3932], 'Kim': [1134, 1390, 1586, 1896, 2014, 2059, 2265, 2543, 2995, 3098, 3933], 'D.-H.': [1135, 1897, 2015, 2060, 2266, 2544, 2996, 3099, 3934], '2007;': [1139, 1901, 2019, 2064, 2270, 2548, 3000, 3103, 3938], '9:': [1140, 1902, 2020, 2065, 2271, 2549, 3001, 3104, 3939], '316-323Crossref': [1141, 1903, 2021, 2066, 2272, 2550, 3002, 3105, 3940], '(936)': [1144, 1906, 2024, 2069, 2275, 2553, 3005, 3108, 3943], 'phosphorylations': [1149], 'at': [1151, 1580, 2374, 2583, 2822, 3352, 3810], 'least': [1152], 'regulators': [1154], '4E-BP1,': [1160], 'mediates': [1162], 'insulin': [1165, 1928, 1982], '15Burnett': [1198], 'P.E.': [1199], 'Barrow': [1200], 'R.K.': [1201, 1742, 3136, 3193, 3544, 3672, 3719], 'Cohen': [1202], 'N.A.': [1203], 'Snyder': [1204], 'Proc.': [1208], 'Natl.': [1209], 'Acad.': [1210], 'Sci.': [1211], 'U.': [1212], '1998;': [1215], '95:': [1216], '1432-1437Crossref': [1217], '(947)': [1220], 'regulated': [1225], 'TSC-Rheb': [1227], '(tuberous': [1228], 'sclerosis': [1229], 'complex-Ras': [1230], 'homolog-enriched': [1231], 'brain)': [1233], '(16Inoki': [1235], 'Li': [1237], 'Zhu': [1239], 'Wu': [1241], '648-657Crossref': [1250], '(2421)': [1253], '17Manning': [1256], 'B.D.': [1257], 'Tee': [1258], 'A.R.': [1259], 'Logsdon': [1260], 'Blenis': [1262], 'Cantley': [1264], 'L.C.': [1265], '151-162Abstract': [1270], '(1286)': [1278], '18Zhang': [1281], 'Gao': [1283], 'Saucedo': [1285], 'L.J.': [1286], 'Edgar': [1289], 'B.A.': [1290], '5:': [1297, 2303], '578-581Crossref': [1298], '(720)': [1301], '19Long': [1304], 'Lin': [1306, 1423, 1619], 'Ortiz-Vega': [1308], 'Curr.': [1314, 1402, 1598, 3960], '15:': [1317], '702-713Abstract': [1318], '(758)': [1326], 'does': [1339, 3248], 'likely': [1341, 4332], 'bind': [1342], 'rapamycin-FK506-binding': [1343], '12': [1345], 'complex,': [1346], 'which': [1347, 3753], 'makes': [1348], 'distinctive': [1350], '(13Loewith': [1353, 1472], '20Sarbassov': [1386], 'Guertin': [1392, 1588, 1640], 'D.A.': [1393, 1589, 1641], '14:': [1405, 1547, 1601], '1296-1302Abstract': [1406, 1602], '(2177)': [1414, 1610], '21Jacinto': [1417, 1613], 'Loewith': [1419, 1507, 1615], 'Schmidt': [1421, 1617], 'Ruegg': [1425, 1621], 'M.A.': [1426, 1622, 3947], 'Nature': [1431, 1627], '6:': [1435, 1631], '1122-1128Crossref': [1436, 1632], '(1701)': [1439, 1635], 'Saccharomyces': [1442], 'cerevisiae': [1443], 'TORC2': [1444], 'TOR2,': [1447], 'LST8,': [1448], 'AVO1': [1449], '(Sin1': [1450], 'ortholog),': [1451], 'AVO3': [1453], '(rictor': [1454], 'ortholog)': [1455], 'other': [1458, 1701, 2463, 2565], 'components,': [1459], 'AVO2': [1460, 1695], 'BIT61,': [1462, 1697], 'whose': [1463, 3269], 'homologues': [1464, 1693, 3271], 'identified': [1468, 1691, 1719, 1785, 3055, 3113], 'higher': [1470, 3228, 3792, 4319, 4338], 'eukaryotes': [1471], '22Wullschleger': [1505], 'Chem.': [1515, 1661, 2319], '280:': [1517, 1663], '30697-30704Abstract': [1518], '(190)': [1526], '23Wedaman': [1529], 'K.P.': [1530], 'Reinke': [1531], 'Anderson': [1533], 'Yates': [1535, 2295], 'II': [1537], 'I': [1538], 'McCaffery': [1539], 'Powers': [1541], '1204-1220Crossref': [1548], '(197)': [1551], 'regulatory': [1556], 'mechanisms': [1557], 'remain': [1560], 'largely': [1561], 'unknown.': [1562], 'showed': [1565], 'C': [1571, 1866, 2407, 3334, 3483, 4099], 'α': [1572], 'organization,': [1576], 'Ser-473': [1581], '(20Sarbassov': [1582], '24Sarbassov': [1638], '307:': [1648], '1098-1101Crossref': [1649], '(5294)': [1652], '25Hresko': [1655], 'R.C.': [1656], 'Mueckler': [1657], '40406-40416Abstract': [1664], '(513)': [1672], 'Recognizing': [1675], 'relationship': [1678], 'between': [1679, 2332, 3400, 3443, 4039], 'S6K1,': [1681], 'knowing': [1685], 'yet': [1690], 'hypothesized': [1699], 'unidentified': [1702], 'mTOR-binding': [1703, 2125, 2962, 2984], 'effector': [1704], 'proteins': [1705, 2126, 2689, 2985, 3075, 3268, 3293, 3807, 4279], 'may': [1706], 'provide': [1707], 'clues': [1708], 'mechanism': [1711], 'underlying': [1712], 'In': [1715, 3050, 3634], 'this': [1716, 4057], 'study,': [1717, 2966], 'having': [1729], 'implicative': [1731, 3125], 'function': [1732], 'tumorigenesis': [1734, 3128], '(1Johnstone': [1735, 3129, 3186, 3537, 3665, 3712], 'C.N.': [1736, 3130, 3187, 3538, 3666, 3713], 'Castellvi-Bel': [1737, 3131, 3188, 3539, 3667, 3714], 'Chang': [1739, 3133, 3190, 3541, 3669, 3716], 'L.M.': [1740, 3134, 3191, 3542, 3670, 3717], 'Sung': [1741, 3135, 3192, 3543, 3671, 3718], 'Bowser': [1743, 3137, 3194, 3545, 3673, 3720], 'M.J.': [1744, 3138, 3195, 3546, 3674, 3721], 'Pique': [1745, 3139, 3196, 3547, 3675, 3722], 'Castells': [1747, 3141, 3198, 3549, 3677, 3724], 'Rustgi': [1749, 2373, 3143, 3200, 3551, 3679, 3726], 'A.K.': [1750, 3144, 3201, 3552, 3680, 3727], 'Genomics.': [1751, 3145, 3202, 3553, 3681, 3728], '85:': [1753, 3147, 3204, 3555, 3683, 3730], '338-351Crossref': [1754, 3148, 3205, 3556, 3684, 3731], '(25)': [1757, 3151, 3208, 3559, 3687, 3734], 'We': [1760, 1784, 3037, 3463, 3598, 3815, 4197], 'determined': [1761, 1796, 3864], 'specifically': [1764, 3077, 3361, 3517, 3775], 'tighter': [1775], 'than': [1776, 3349, 3802, 3825], 'rictor-mTOR': [1778, 4051], 'mTOR.': [1783], 'residues': [1789, 3218, 3280, 4301, 4316, 4344], 'crucial': [1790], 'PRR5-rictor': [1793, 4086, 4105], 'PDGF': [1805, 1972], 'S6K1.': [1810], 'Reagents': [1811], 'Antibodies—Anti-mTOR': [1813], '(sc-1549),': [1814], '(EGFR)': [1819], '(sc-03),': [1820], 'Fas': [1821], '(sc-20140),': [1822], 'p21': [1823], '(sc-397),': [1824], 'tubulin': [1825], '(sc-12462),': [1826], 'PDFGR': [1827], '(sc-432),': [1828], 'glyceraldehyde-3-phosphate': [1829], 'dehydrogenase': [1830], '(sc-25778),': [1831], '14-3-3': [1833], '(sc-732)': [1834], 'antibodies': [1835, 1846, 1874, 1880, 1932, 3435, 3466, 3524], 'were': [1836, 1851, 1881, 1933, 1973, 1990, 2108, 2127, 2206, 2218, 2248, 2281, 2379, 2410, 2426, 2447, 2569, 2594, 2613, 2635, 2670, 2690, 2766, 2778, 2795, 2817, 2829, 2906, 3031, 3072, 3115, 3808], 'purchased': [1837, 1974, 1984], 'Santa': [1839], 'Cruz': [1840], 'Biotechnology': [1841], '(Santa': [1842], 'Cruz,': [1843], 'CA).': [1844, 1876, 1956, 1964, 1980, 2856], 'Polyclonal': [1845], 'specific': [1847, 3398, 3441, 3467, 4255], 'generated': [1852, 2411, 2907, 3464], 'against': [1853, 1910], 'full-length': [1854, 3475], 'fused': [1856], 'epitope': [1862, 3479], 'peptide': [1863, 2337, 3419, 3428, 3480], 'near': [1864, 3332, 3481], 'terminus': [1867, 3335, 3484], 'containing': [1868, 2076, 2135, 2576, 3212, 4094], 'sequence': [1870, 2279, 2338, 2742, 3283], 'RGSGMSDLEGSGGR': [1871], 'YenZym': [1873], '(Burlingame,': [1875], 'Raptor-': [1877], 'rictor-specific': [1879], 'described': [1882, 2000, 2048, 2251, 2472, 2968], 'our': [1884, 2002, 2253, 2964], 'previous': [1885, 2003, 2254], '(14Vander': [1887, 2005, 2050, 2256, 2986, 3089, 3924], 'Antibodies': [1909], '(9202),': [1912], 'phospho-S6K1': [1913], 'Thr-389': [1914], '(p-S6K1;': [1915], '9205),': [1916], '(9272),': [1918], 'phospho-Akt': [1919], 'Ser-372': [1920], '(p-Akt;': [1921], '9271),': [1922], '4E-BP1': [1923], '(9452),': [1924], 'phospho-4E-BP1': [1925], '(2855),': [1926], '(3025)': [1931], 'Signaling': [1936], 'Technology': [1937], '(Danvers,': [1938], 'MA).': [1939, 2242], 'Rabbit': [1940], 'IgG': [1941], 'TrueBlot': [1942], '(18–8816)': [1943], 'detect': [1946], 'immunoprecipitates': [1949, 2107, 3085, 3431, 3452, 3460], 'was': [1950, 1960, 1983, 2027, 2042, 2140, 2166, 2440, 2743, 2846, 2861, 2881, 2925, 2944, 3175, 3367, 3391, 3405, 3449, 3491, 3760, 3797, 4088], 'obtained': [1951, 3368, 3432], 'eBioscience': [1953], '(San': [1954, 1978], 'Diego,': [1955, 1979], 'Anti-HA': [1957], 'antibody': [1958, 3490, 3645], '(HA.11)': [1959], 'Covance': [1962], '(Berkeley,': [1963], 'Anti-Myc': [1965], '9E10': [1966], 'factors': [1969], 'EGF': [1970], 'EMD': [1976], 'Biosciences': [1977], 'Porcine': [1981], 'Sigma.': [1986], 'Glutathione': [1987], '4B': [1988, 2655], 'beads': [1989, 2656], 'GE': [1992], 'Healthcare.': [1993], 'Identification': [1994, 2957], 'PRR5—The': [1996], 'strategy': [1997], 'study': [2004, 2255], 'Scholar)': [2026, 2071, 2327], 'modifications': [2030], 'steps': [2032], 'immunoprecipitation': [2034, 2981, 3520], 'preparation': [2036], 'trypsinized': [2038, 2164, 2830], 'samples.': [2039, 2200], 'immunoprecipitate': [2041, 2131, 3080, 3366, 3410, 3891], 'prepared': [2043, 2671, 2862], 'HEK293T': [2045, 2592, 2746, 3370], 'cells': [2046, 2593, 2639, 2747, 2777, 2812, 2828, 2865, 3371, 3857, 4203], 'previously': [2049, 2471, 3176, 3536], 'using': [2072, 2283, 2602, 2762, 2870, 2889, 2911, 2927, 2946, 3433, 3471], 'lysis': [2074, 2114, 2120, 4092], 'buffer': [2075, 2115, 2121, 2134, 2146, 2675, 4093], 'mm': [2078, 2083, 2086, 2089, 2092, 2095, 2148, 2152, 2646], 'Hepes,': [2079], 'pH': [2080, 2154, 2175], '7.4,': [2081], '120': [2082], 'NaCl,': [2084], 'EDTA,': [2087], '50': [2088], 'NaF,': [2090], '1.5': [2091], 'Na3VO4,': [2093], '10': [2094], 'β-glycerophosphate,': [2096], '0.3%': [2097, 2673, 2695], 'Chaps,': [2098], 'EDTA-free': [2100], 'protease': [2101], 'inhibitors': [2102], '(Roche': [2103, 2394, 2605], 'Applied': [2104, 2395, 2606], 'Science).': [2105, 2396], 'washed': [2109, 2691], 'four': [2110, 2692, 2784], 'times': [2111, 2693, 2785, 2834], 'twice': [2117], 'without': [2122, 3010], 'detergent.': [2124], 'eluted': [2128, 2207], '0.075%': [2136], 'SDS.': [2137], 'eluate': [2139], 'diluted': [2141, 2167, 2832, 2843], 'trypsin': [2144, 2159], 'digestion': [2145], '(25': [2147], 'ammonium': [2149, 2210], 'bicarbonate,': [2150], '2.5': [2151], 'CaCl2,': [2153], '8.0)': [2155], 'incubated': [2157], '(2': [2160], 'μg)': [2161], 'overnight.': [2162], 'sample': [2165, 3039], '0.1%': [2169, 2221], 'formic': [2170, 2222], 'obtain': [2173], 'below': [2176], '3.0': [2177], 'loaded': [2179, 2698, 2847], 'onto': [2180, 2699, 2708], 'mixed': [2182], 'mode': [2183], 'cation': [2184], 'exchange': [2185], 'cartridge': [2186], '(MCX': [2187], 'cartridge;': [2188], 'Waters': [2189], 'Inc.,': [2190, 2854], 'Milford,': [2191], 'MA)': [2192], 'remove': [2194], 'salt': [2195], 'detergent': [2197, 4111], 'Peptides': [2201], 'bound': [2202, 3799], 'resin': [2205], '5%': [2209, 2587], 'hydroxide': [2211], 'methanol': [2213], 'lyophilized.': [2215], 'Lyophilized': [2216], 'samples': [2217], 'dissolved': [2219], 'analyzed': [2225, 2249, 3392, 4205], 'microcapillary': [2227], 'electrospray': [2228, 2234, 2973], 'tandem': [2229], 'mass': [2230, 2238, 2244, 2977, 3043], 'spectrometry': [2231, 2245, 3044], 'linear': [2235, 2974], 'ion': [2236, 2975], 'trap': [2237, 2976], 'spectrometer': [2239, 2978], '(ThermoElectron,': [2240], 'Waltham,': [2241], 'Tandem': [2243], 'spectral': [2246], 'data': [2247, 3664], 'Peptide': [2278, 2289], 'matches': [2280], 'filtered': [2282], 'probabilistic': [2285], 'scoring': [2286], 'algorithm': [2287], 'called': [2288], 'Prophet': [2290], '(26Eng': [2291], 'J.K.': [2292], 'McCormack': [2293], 'J.R.': [2296], 'Am.': [2298], 'Soc.': [2299], 'Mass.': [2300], 'Spectrom.': [2301], '1994;': [2302], '976-989Crossref': [2304], '(5472)': [2307], '27Keller': [2310], 'Nesvizhskii': [2312], 'A.I.': [2313], 'Kolker': [2314], 'Aebersold': [2316], 'Anal.': [2318], '74:': [2321], '5383-5392Crossref': [2322], '(3912)': [2325], 'assigns': [2329], 'value': [2331], '0': [2333], 'matches,': [2339, 3070], 'score': [2342], 'representing': [2345], 'highest': [2347], 'confidence': [2348], 'match.': [2349], 'Plasmid': [2350], 'Constructions': [2351], 'Mutagenesis—PRR5': [2353], 'cDNAs': [2354], 'isoforms': [2356, 2625, 3182, 3388, 3653, 4190, 4200, 4216, 4222, 4242, 4258, 4267], '1,': [2357, 2626], '2,': [2358, 2627, 3380, 3656, 4245, 4270], '3': [2360, 2629, 2797, 3341, 4250], 'origin': [2363], 'kindly': [2364], 'provided': [2365], 'Dr.': [2367, 2371, 2435, 2757], 'Johnstone': [2369], 'University': [2376], 'Pennsylvania': [2378], 'cloned': [2380, 2630], 'into': [2381, 2417, 2745, 2819], 'prk5-myc': [2382], 'prk5-HA': [2384], 'vectors': [2386, 2751], 'use': [2388], 'PCR': [2391, 2413, 2858, 2897, 2904, 2909, 3663], 'amplification': [2392, 2414, 2910], 'kit': [2393, 2894], 'DNA': [2401, 2914], 'fragments': [2402], 'Fig.': [2405, 3277, 4323], '4,': [2406], 'D,': [2409], 'subcloned': [2416], 'vector': [2420, 2432], 'prk5-myc,': [2421], 'all': [2423, 4188], 'clones': [2425], 'confirmed': [2427, 3511], 'sequencing.': [2429], 'pLKO': [2430], 'shRNA': [2431, 2600, 2735, 3861], '(provided': [2433, 2755], 'Stewart,': [2437, 2759], 'Washington': [2438, 2760], 'University)': [2439, 2761], 'knockdown': [2443], 'experiments.': [2444], 'Target': [2445], 'sequences': [2446], '5′-catgctgcaggccatcttcta-3′': [2448], '(sh-PRR5': [2449, 2452], '4),': [2450], '5′-ggacaagattcgcttctatga-3′': [2451], '15),': [2453], '5′-aaccctgcctttgtcatgcct-3′': [2454], '(sh-mTOR),': [2455], '5′-caccaccaaagcaacctatag-3′': [2456], '(sh-rictor),': [2457], '5′-aacgtacgcggaatacttcga-3′': [2459], '(scrambled': [2460], 'shRNA).': [2461], 'All': [2462], 'constructs': [2464], 'experiments': [2468], 'Culture': [2557], 'Transfection—HEK293T,': [2559], 'HeLa,': [2560, 3615], 'HT1080,': [2561, 3621], 'HepG2': [2562], 'cells,': [2563, 3636, 3697], 'cancer': [2566, 3625], 'lines': [2568, 3611, 3627], 'cultured': [2570], "Dulbecco's": [2572, 2836], 'modified': [2573, 2837, 3038], "Eagle's": [2574, 2838], 'medium': [2575, 2770], '10%': [2577], 'fetal': [2578], 'bovine': [2579], 'serum': [2580], 'penicillin/streptomycin': [2582], '37': [2584], '°C': [2585], 'CO2.': [2588], 'For': [2589], 'transient': [2590], 'expression,': [2591], 'transfected': [2595], 'recombinant': [2597, 3454], 'DNAs': [2598], 'plasmids': [2601], 'FuGENE': [2603, 2763], '6': [2604], 'Science)': [2607], 'following': [2608], "manufacturer's": [2610, 2877], 'protocol.': [2611, 2661], 'Cells': [2612, 2794], 'harvested': [2614, 2796], 'days': [2616, 2800], 'post-transfection': [2617], 'co-immunoprecipitation': [2619, 2666], 'assay.': [2620], 'Recombinant': [2621], 'Protein': [2622], 'Production—GST-tagged': [2623], 'pGEX6T-2': [2632], '(Amersham': [2633], 'Biosciences)': [2634, 2641], 'expressed': [2636, 3377, 3383, 3603, 3694, 3809, 4198, 4275], 'BL21(DE3)': [2638], '(EMD': [2640], 'induction': [2643], '0.1': [2645], 'isopropyl-1-thio-β-d-galactopyranoside': [2647], '16': [2649], 'h': [2650, 2707, 2772, 2788], 'purified': [2652, 3411, 3516], 'glutathione-Sepharose': [2654], 'according': [2657, 2874], 'standard': [2660], 'Co-immunoprecipitation': [2662], 'Western': [2664, 2718, 3394], 'Blotting—For': [2665], 'studies,': [2667], 'whole-cell': [2668], 'extracts': [2669], 'Chaps': [2674, 2696], 'immunoprecipitated': [2677, 3642, 4239], 'anti-mTOR,': [2680], 'anti-raptor,': [2681], 'anti-rictor,': [2682], 'anti-PRR5,': [2683], 'anti-HA,': [2684], 'anti-Myc': [2686], 'antibodies.': [2687], 'Precipitated': [2688], 'buffer,': [2697], '8%': [2700], 'Tris-glycine': [2701], 'gels': [2702], '(Invitrogen),': [2703], 'transferred': [2704], '4': [2706], 'immunoblot': [2709], 'polyvinylidene': [2710], 'difluoride': [2711], 'membranes': [2712], '(Bio-Rad),': [2713], 'detected': [2715, 3073, 3406, 3575, 3761], 'ECL': [2717], 'blotting': [2719], 'detection': [2720, 3021], 'reagents': [2721], '(Perkin-Elmer).': [2722], 'Lentiviral': [2723], 'Preparation,': [2724], 'Viral': [2725], 'Infection,': [2726], 'Stable': [2728], 'Generation—A': [2730], 'pLKO-shRNA': [2731], 'plasmid': [2732], 'encoding': [2733], 'targets': [2737, 3776], 'scrambled': [2741], 'transduced': [2744, 2813, 2866], 'lentiviral': [2749, 2815, 2868, 3860], 'packaging': [2750], 'pHR′8.2ΔR': [2752], 'pCMV-VSV-G': [2754], '6.': [2764], 'Viruses': [2765], 'collected': [2767, 2782], '60': [2771], 'after': [2773], 'transfection,': [2774], 'infected': [2779], 'viruses': [2783], 'over': [2786], '15': [2787], 'presence': [2791, 3424], 'polybrene.': [2793], '5': [2799, 2884], 'post-infection': [2801], 'selected': [2803], 'puromycin': [2805], 'days.': [2808], 'Proliferation': [2810], 'Assay—HeLa': [2811], 'shRNAs': [2816, 2869], 'split': [2818], '6-cm': [2820], 'plates': [2821], '20%': [2823], 'confluence;': [2824], 'next': [2826], 'day': [2827], 'ten': [2833], 'medium.': [2839], 'One': [2840], 'ml': [2841], 'culture': [2845], 'ViCell': [2850], 'analyzer': [2851], '(Beckman': [2852], 'Coulter': [2853], 'Fullerton,': [2855], 'Real-time': [2857], 'Analysis—Total': [2859], 'RNA': [2860, 2888], 'HeLa': [2864], 'TRIzol': [2871], 'reagent': [2872], '(Invitrogen)': [2873], 'instructions.': [2878], 'Single-stranded': [2879], 'cDNA': [2880, 2892, 2924, 2943], 'synthesized': [2882], 'μg': [2885], 'total': [2887], 'iScript': [2891], 'real-time': [2896], '(Bio-Rad)': [2898], 'resuspended': [2900], 'diethylpyrocarbonate-treated': [2902], 'water.': [2903], 'products': [2905], 'Lightcycler': [2912], 'Faststart': [2913], 'Masterplus': [2915], 'SYBR': [2916], 'Green': [2917], '(Bio-Rad).': [2919], 'Amplification': [2920, 2938], 'performed': [2926, 2945], 'forward': [2929, 2948], 'primer,': [2930, 2936, 2949, 2955], '5′-tgtgacggagagtgtgaatgac-3′,': [2931], 'paired': [2932, 2951], 'reverse': [2935, 2954, 3661], '5′-agggtgcggttgtctttgaac-3′.': [2937], 'TATA': [2940], 'box-binding': [2941], '5′-taatcccaagcggtttgctg-3′,': [2950], '5′-gcacaccattttcccagaactg-3′.': [2956], 'Protein—In': [2963], 'recent': [2965], 'approach': [2970], 'combining': [2971], 'identify': [2983, 3026], 'This': [3008], 'approach,': [3009], 'relying': [3011], 'SDS-PAGE': [3013], 'separation': [3014], 'proteins,': [3016], 'increased': [3017], 'sensitivity': [3019], 'led': [3023, 3877], 'us': [3024], 'PRAS40': [3027], 'Sin1': [3029, 4023, 4075], 'barely': [3032], 'detectable': [3033], 'Coomassie-stained': [3035], 'gels.': [3036], 'preparative': [3040], 'detailed': [3046], '“Experimental': [3048], 'Procedures.”': [3049], 'new': [3052], 'preparation,': [3053], 'three': [3056, 3112, 3387], 'peptides': [3057, 3114], 'high': [3059, 3214], 'scores': [3060], 'P': [3062], 'value,': [3063], 'parameter': [3065], 'fidelity': [3067], 'MS/MS': [3069], 'isolated': [3076, 3450], 'control': [3084, 3434, 3459, 3523], '(supplemental': [3086, 3276, 4322], 'Table': [3087], '1)': [3088, 3323], 'chromosome': [3160], '22q13.31,': [3161], 'carcinogenesis.': [3173], 'shown': [3177, 3586, 3916], 'exist': [3179], 'splicing': [3184], 'variants': [3185], 'content': [3215], 'proline': [3217], '(28': [3219], 'among': [3220, 4318], '388': [3221, 3325], 'amino': [3222, 3326, 3346, 4298], 'acids,': [3223], '7.2%),': [3224], 'conserved': [3226, 4317], 'eukaryotes.': [3229, 4339], 'BLAST': [3230], 'search': [3231, 4341], 'revealed': [3232], 'shares': [3236], '33–86%': [3237], 'identity': [3238], 'genes': [3240, 3253, 4321], 'amphibians,': [3242], 'fishes,': [3243], 'rodents,': [3244], 'primates': [3246], 'show': [3250], 'similarity': [3251, 3284], 'Drosophila': [3255], 'melanogaster': [3256], 'Caenorhabditis': [3258], 'elegans': [3259], 'well': [3261], 'BIT61': [3263], 'AVO2,': [3265], 'TOR2-interacting': [3267], 'found': [3275, 3291], 'S1).': [3278], '91–169': [3281], 'share': [3282], 'HbrB': [3287], 'domain,': [3288], 'domain': [3290], 'involved': [3294], 'hyphal': [3296], 'polarity': [3299], '(28Gatherar': [3300], 'I.M.': [3301], 'Pollerman': [3302], 'Dunn-Coleman': [3304], 'Turner': [3306], 'Fungal': [3308], 'Genet.': [3309], '41:': [3312], '463-471Crossref': [3313], '(22)': [3316], 'longest': [3320], 'isoform': [3321, 3350, 3379, 4249, 4273], '(isoform': [3322], 'contains': [3324, 3756, 3789], 'acids': [3327, 3347, 4299], '(Fig.': [3336, 3389, 3436, 3461, 3504, 3525, 3632, 3646, 3778, 3813, 3907, 4053, 4077, 4097, 4251, 4289], '1A).': [3337], 'Isoforms': [3338], '9': [3343], '95': [3345, 4297], 'shorter': [3348], 'N': [3354], 'terminus,': [3355], 'respectively.': [3356], 'To': [3357, 3840, 4340], 'confirm': [3358], 'amount': [3374, 3651, 3793, 3866, 3884, 4207], 'transiently': [3376], 'highly': [3382, 3574, 3693], '1A),': [3390], 'blotting.': [3395], 'Supporting': [3396, 3780, 4220], 'only': [3407, 3888, 4266], 'absence': [3414], 'antibody-blocking': [3418], 'blocking': [3427], '1B).': [3437], 'Consistent': [3438, 4055], 'endogenous': [3447, 3496, 3502, 3513, 4209, 4234, 4285], '1C).': [3462], 'polyclonal': [3465], 'GST': [3472, 4277], 'fusion': [3473, 4278], 'antigen.': [3487], 'latter': [3489], 'able': [3492], 'pull': [3494], '1D).': [3505], 'Using': [3506], 'PRR5-specific': [3508], 'antibody,': [3509], 'anti-mTOR': [3519], '1E).': [3526], 'Tissue': [3527], 'distribution': [3528], 'mRNA': [3532, 3563, 3707], 'had': [3533, 3585], 'reported': [3535], 'most': [3565, 3692, 3710], 'abundant': [3566, 3711], 'liver.': [3570], 'It': [3571], 'also': [3573, 3893], 'brain,': [3577], 'spleen,': [3578, 3594], 'testis,': [3579, 3595], 'placenta.': [3581], 'Northern': [3582], 'blot': [3583], 'analysis': [3584], 'multiple': [3587], 'different-sized': [3588], 'bands': [3589], 'evident': [3590], 'tissues': [3592], 'heart.': [3597], 'observed': [3599, 3638, 4232], 'different': [3605], 'amounts': [3606], '293T,': [3614], 'HepG2,': [3616], 'fibrosarcoma': [3618], 'line': [3620, 3700], 'MCF-7,': [3628], 'T47D,': [3629], 'MDA-MB-231': [3631, 3648], '1F).': [3633], '1G).': [3647], 'expresses': [3649], 'transcription': [3662], '293T': [3696, 3856, 4202], 'where': [3705], 'Is': [3738], 'Component': [3740], 'mTORC2—Knowing': [3742], 'questioned': [3752, 4186], 'PRR5.': [3757], 'Importantly,': [3758], 'immunoprecipitates,': [3766, 3771], 'suggesting': [3772], '2A).': [3779], 'large': [3783], 'proportion': [3784], 'Myc-tagged': [3795, 3806], 'recovered': [3798, 4213], 'Myc-mTOR,': [3803], 'although': [3804], 'both': [3805], 'similar': [3811], '2B).': [3814], 'thought': [3816], 'stronger': [3819], 'association': [3820], 'might': [3827], 'support': [3828], 'mediation': [3835], 'PRR5-mTOR': [3838, 4081], 'test': [3841], 'possibility': [3843], 'requires': [3849], 'knocked': [3852], 'transduction': [3862], 'immunoprecipitate.': [3874, 4219], 'Rictor': [3875], 'lysate,': [3896], 'indicating': [3897, 4102], 'stability': [3904], '3A).': [3908, 4054], 'be': [3918], '29Frias': [3946], 'Thoreen': [3948], 'Jaffe': [3950], 'J.D.': [3951], 'Schroder': [3952], 'Sculley': [3954], 'Carr': [3956], 'S.A.': [3957], '2006;': [3962, 3994, 4014], '16:': [3963], '1-6Abstract': [3964], '(555)': [3972], '30Jacinto': [3975], 'Facchinetti': [3977], 'V.': [3978], 'Liu': [3979], 'Soto': [3981], 'Wei': [3983], 'Jung': [3985], 'S.Y.': [3986], 'Huang': [3987], 'Q.': [3988, 4005], 'Qin': [3989], 'Su': [3991], '126:': [3995], '1-13Abstract': [3996], '31Yang': [4004], 'Ikenoue': [4008], '20:': [4015], '2820-2832Crossref': [4016], '(410)': [4019], 'Unlike': [4022], 'silencing,': [4024], 'did': [4027, 4062], 'change': [4032], 'affinity': [4035, 4066], 'supporting': [4043, 4325], 'result,': [4058], 'overexpression': [4059, 4076], 'alter': [4064], 'interaction,': [4070, 4082, 4087], 'stabilized': [4073], '3B).': [4078], 'Furthermore,': [4079], 'destabilized': [4089], 'Triton': [4095], 'X-100': [4096], '3,': [4098, 4274], 'D),': [4101], 'resistant': [4108], 'condition': [4112], 'disrupts': [4114], 'results': [4149, 4292], 'demonstrate': [4150], 'binds': [4153], 'preferentially': [4155], 'independently': [4157], 'mTOR-PRR5': [4166], 'Residues': [4169], '10–95': [4170], '188–218': [4172], 'Are': [4173], 'Crucial': [4174], 'Binding': [4176], 'Rictor—Knowing': [4177], 'whether': [4187], 'interact': [4191, 4226], 'isoforms.': [4196], 'HA-tagged': [4199, 4241], 'HA-PPR5': [4215], 'HA': [4218], '4A).': [4252], 'Confirming': [4253], 'Escherichia': [4281], 'coli': [4282], 'pulled': [4283], '4B).': [4290], 'suggest': [4293], 'N-terminal': [4296, 4309], 'contain': [4300], 'rictor.': [4307], 'overlaps': [4313], 'eukaryotic': [4320], 'S1),': [4324], 'evolution': [4336], 'C-terminal': [4343], 'made': [4352], 'C-terminal-truncated': [4353], 'mutants': [4354, 4360], 'tested': [4358], 'their': [4362], 'ability': [4363], 'bi': [4365]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2050696207', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 8}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 7}, {'year': 2018, 'cited_by_count': 8}, {'year': 2017, 'cited_by_count': 8}, {'year': 2016, 'cited_by_count': 8}, {'year': 2015, 'cited_by_count': 16}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 11}, {'year': 2012, 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