Title: Characterization of JadH as an FAD‐ and NAD(P)H‐Dependent Bifunctional Hydroxylase/Dehydrase in Jadomycin Biosynthesis
Abstract: ChemBioChemVolume 11, Issue 8 p. 1055-1060 Communication Characterization of JadH as an FAD- and NAD(P)H-Dependent Bifunctional Hydroxylase/Dehydrase in Jadomycin Biosynthesis Yihua Chen Dr., Yihua Chen Dr. State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101 (China), Fax: (+86) 10-64807459 Present address: Division of Pharmaceutical Sciences, University of Wisconsin–Madison, 777 Highland Avenue, Madison, WI 53705 78 (USA) These authors contributed equally to this work.Search for more papers by this authorKeqiang Fan Dr., Keqiang Fan Dr. State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101 (China), Fax: (+86) 10-64807459 These authors contributed equally to this work.Search for more papers by this authorYongzhi He, Yongzhi He State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101 (China), Fax: (+86) 10-64807459Search for more papers by this authorXinping Xu Dr., Xinping Xu Dr. State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101 (China), Fax: (+86) 10-64807459Search for more papers by this authorYanfeng Peng Dr., Yanfeng Peng Dr. State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101 (China), Fax: (+86) 10-64807459Search for more papers by this authorTingting Yu, Tingting Yu State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101 (China), Fax: (+86) 10-64807459Search for more papers by this authorCuijuan Jia, Cuijuan Jia State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101 (China), Fax: (+86) 10-64807459Search for more papers by this authorKeqian Yang Prof. Dr., Keqian Yang Prof. Dr. [email protected] State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101 (China), Fax: (+86) 10-64807459Search for more papers by this author Yihua Chen Dr., Yihua Chen Dr. State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101 (China), Fax: (+86) 10-64807459 Present address: Division of Pharmaceutical Sciences, University of Wisconsin–Madison, 777 Highland Avenue, Madison, WI 53705 78 (USA) These authors contributed equally to this work.Search for more papers by this authorKeqiang Fan Dr., Keqiang Fan Dr. State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101 (China), Fax: (+86) 10-64807459 These authors contributed equally to this work.Search for more papers by this authorYongzhi He, Yongzhi He State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101 (China), Fax: (+86) 10-64807459Search for more papers by this authorXinping Xu Dr., Xinping Xu Dr. State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101 (China), Fax: (+86) 10-64807459Search for more papers by this authorYanfeng Peng Dr., Yanfeng Peng Dr. State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101 (China), Fax: (+86) 10-64807459Search for more papers by this authorTingting Yu, Tingting Yu State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101 (China), Fax: (+86) 10-64807459Search for more papers by this authorCuijuan Jia, Cuijuan Jia State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101 (China), Fax: (+86) 10-64807459Search for more papers by this authorKeqian Yang Prof. Dr., Keqian Yang Prof. Dr. [email protected] State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101 (China), Fax: (+86) 10-64807459Search for more papers by this author First published: 10 May 2010 https://doi.org/10.1002/cbic.201000178Citations: 29 Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Biosynthesis of angucyclines: We characterized an accessory enzyme, JadH as a FAD and NAD(P)H-dependent bifunctional hydroxylase/dehydrase involved in jadomycin biosynthesis by identifying its real product. Homologues of JadH have been found in all cloned angucycline biosynthetic clusters and were proposed to have similar functions as JadH. Citing Literature Supporting Information Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Filename Description cbic_201000178_sm_miscellaneous_information.pdf1.1 MB miscellaneous_information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume11, Issue8May 17, 2010Pages 1055-1060 RelatedInformation
Publication Year: 2010
Publication Date: 2010-04-28
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 33
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