Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2050574427', 'doi': 'https://doi.org/10.1016/j.jsbmb.2005.04.040', 'title': 'Transcriptional inhibition of the estrogen response element by antiestrogenic piperidinediones correlates with intercalation into DNA measured by energy calculations', 'display_name': 'Transcriptional inhibition of the estrogen response element by antiestrogenic piperidinediones correlates with intercalation into DNA measured by energy calculations', 'publication_year': 2005, 'publication_date': '2005-07-29', 'ids': {'openalex': 'https://openalex.org/W2050574427', 'doi': 'https://doi.org/10.1016/j.jsbmb.2005.04.040', 'mag': '2050574427', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/16054810'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.jsbmb.2005.04.040', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168421034', 'display_name': 'The Journal of Steroid Biochemistry and Molecular Biology', 'issn_l': '0960-0760', 'issn': ['0960-0760', '1879-1220'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5024539701', 'display_name': 'Neil Sidell', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I150468666', 'display_name': 'Emory University', 'ror': 'https://ror.org/03czfpz43', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I150468666']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Neil Sidell', 'raw_affiliation_strings': ['Department of Gynceology and Obstetrics, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Gynceology and Obstetrics, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA', 'institution_ids': ['https://openalex.org/I150468666']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001301406', 'display_name': 'Prasong Tanmahasamut', 'orcid': 'https://orcid.org/0000-0002-5152-1725'}, 'institutions': [{'id': 'https://openalex.org/I150468666', 'display_name': 'Emory University', 'ror': 'https://ror.org/03czfpz43', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I150468666']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Prasong Tanmahasamut', 'raw_affiliation_strings': ['Department of Gynceology and Obstetrics, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Gynceology and Obstetrics, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA', 'institution_ids': ['https://openalex.org/I150468666']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027657161', 'display_name': 'Douglas E. Ewing', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Douglas E. Ewing', 'raw_affiliation_strings': ['Accelerated Pharmaceuticals, Inc., 3528 Stevens Way, Augusta, GA, USA'], 'affiliations': [{'raw_affiliation_string': 'Accelerated Pharmaceuticals, Inc., 3528 Stevens Way, Augusta, GA, USA', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5103404427', 'display_name': 'Lawrence B. Hendry', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Lawrence B. Hendry', 'raw_affiliation_strings': ['Accelerated Pharmaceuticals, Inc., 3528 Stevens Way, Augusta, GA, USA'], 'affiliations': [{'raw_affiliation_string': 'Accelerated Pharmaceuticals, Inc., 3528 Stevens Way, Augusta, GA, USA', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3710, 'currency': 'USD', 'value_usd': 3710, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.037, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 12, 'citation_normalized_percentile': {'value': 0.644861, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 82, 'max': 83}, 'biblio': {'volume': '96', 'issue': '5', 'first_page': '335', 'last_page': '345'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10756', 'display_name': 'Estrogen and related hormone effects', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10756', 'display_name': 'Estrogen and related hormone effects', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10432', 'display_name': 'DNA and Nucleic Acid Chemistry', 'score': 0.9972, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12356', 'display_name': 'Bioactive Compounds and Antitumor Agents', 'score': 0.9884, 'subfield': {'id': 'https://openalex.org/subfields/3005', 'display_name': 'Toxicology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/hormone-response-element', 'display_name': 'Hormone response element', 'score': 0.77438796}, {'id': 'https://openalex.org/keywords/response-element', 'display_name': 'Response element', 'score': 0.42684835}], 'concepts': [{'id': 'https://openalex.org/C1292079', 'wikidata': 'https://www.wikidata.org/wiki/Q3817769', 'display_name': 'Transactivation', 'level': 4, 'score': 0.9556983}, {'id': 'https://openalex.org/C51445715', 'wikidata': 'https://www.wikidata.org/wiki/Q410477', 'display_name': 'Hormone response element', 'level': 5, 'score': 0.77438796}, {'id': 'https://openalex.org/C161733203', 'wikidata': 'https://www.wikidata.org/wiki/Q911828', 'display_name': 'Reporter gene', 'level': 4, 'score': 0.7129523}, {'id': 'https://openalex.org/C84606932', 'wikidata': 'https://www.wikidata.org/wiki/Q416496', 'display_name': 'Estrogen receptor', 'level': 4, 'score': 0.6313633}, {'id': 'https://openalex.org/C2777164284', 'wikidata': 'https://www.wikidata.org/wiki/Q277954', 'display_name': 'Estrogen', 'level': 2, 'score': 0.5336391}, {'id': 'https://openalex.org/C54009773', 'wikidata': 'https://www.wikidata.org/wiki/Q1429031', 'display_name': 'Transfection', 'level': 3, 'score': 0.5148951}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5143991}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.49851584}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.4614699}, {'id': 'https://openalex.org/C132376346', 'wikidata': 'https://www.wikidata.org/wiki/Q7315962', 'display_name': 'Response element', 'level': 5, 'score': 0.42684835}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.38085184}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.3739906}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.33287796}, {'id': 'https://openalex.org/C101762097', 'wikidata': 'https://www.wikidata.org/wiki/Q224093', 'display_name': 'Promoter', 'level': 4, 'score': 0.28660953}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.2779057}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.13672239}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.089809954}, {'id': 'https://openalex.org/C530470458', 'wikidata': 'https://www.wikidata.org/wiki/Q128581', 'display_name': 'Breast cancer', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D004247', 'descriptor_name': 'DNA', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D020847', 'descriptor_name': 'Estrogen Receptor Modulators', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D007364', 'descriptor_name': 'Intercalating Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D010880', 'descriptor_name': 'Piperidines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D020218', 'descriptor_name': 'Response Elements', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D013816', 'descriptor_name': 'Thermodynamics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D014158', 'descriptor_name': 'Transcription, Genetic', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003198', 'descriptor_name': 'Computer Simulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004247', 'descriptor_name': 'DNA', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020847', 'descriptor_name': 'Estrogen Receptor Modulators', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007364', 'descriptor_name': 'Intercalating Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008958', 'descriptor_name': 'Models, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009690', 'descriptor_name': 'Nucleic Acid Conformation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010880', 'descriptor_name': 'Piperidines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020218', 'descriptor_name': 'Response Elements', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014158', 'descriptor_name': 'Transcription, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.jsbmb.2005.04.040', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168421034', 'display_name': 'The Journal of Steroid Biochemistry and Molecular Biology', 'issn_l': '0960-0760', 'issn': ['0960-0760', '1879-1220'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16054810', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.84, 'display_name': 'Affordable and clean energy', 'id': 'https://metadata.un.org/sdg/7'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 53, 'referenced_works': ['https://openalex.org/W1485350399', 'https://openalex.org/W1871475547', 'https://openalex.org/W1964537672', 'https://openalex.org/W1965799928', 'https://openalex.org/W1965843200', 'https://openalex.org/W1972560735', 'https://openalex.org/W1973279436', 'https://openalex.org/W1981706724', 'https://openalex.org/W1984738107', 'https://openalex.org/W1990529844', 'https://openalex.org/W1991356707', 'https://openalex.org/W1994808024', 'https://openalex.org/W1995235768', 'https://openalex.org/W1996251590', 'https://openalex.org/W1999513011', 'https://openalex.org/W2004454505', 'https://openalex.org/W2006729630', 'https://openalex.org/W2009383250', 'https://openalex.org/W2012532138', 'https://openalex.org/W2014259643', 'https://openalex.org/W2016023347', 'https://openalex.org/W2017867414', 'https://openalex.org/W2022820731', 'https://openalex.org/W2023307129', 'https://openalex.org/W2037077714', 'https://openalex.org/W2037487020', 'https://openalex.org/W2040755641', 'https://openalex.org/W2042098234', 'https://openalex.org/W2042112379', 'https://openalex.org/W2045141424', 'https://openalex.org/W2049192519', 'https://openalex.org/W2050843054', 'https://openalex.org/W2055514358', 'https://openalex.org/W2062229879', 'https://openalex.org/W2069466107', 'https://openalex.org/W2073883348', 'https://openalex.org/W2074012434', 'https://openalex.org/W2085124463', 'https://openalex.org/W2096322778', 'https://openalex.org/W2128840922', 'https://openalex.org/W2132185105', 'https://openalex.org/W2132613286', 'https://openalex.org/W2160625740', 'https://openalex.org/W2161239029', 'https://openalex.org/W2164072727', 'https://openalex.org/W2168799094', 'https://openalex.org/W2169465660', 'https://openalex.org/W2416023143', 'https://openalex.org/W2474772547', 'https://openalex.org/W2523565919', 'https://openalex.org/W2952603592', 'https://openalex.org/W4240866307', 'https://openalex.org/W65946607'], 'related_works': ['https://openalex.org/W4312053305', 'https://openalex.org/W2474284116', 'https://openalex.org/W2219120734', 'https://openalex.org/W2118933128', 'https://openalex.org/W2091657485', 'https://openalex.org/W2062904975', 'https://openalex.org/W2050574427', 'https://openalex.org/W2038527518', 'https://openalex.org/W2023866369', 'https://openalex.org/W2011684438'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2050574427', 'counts_by_year': [{'year': 2022, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}], 'updated_date': '2025-01-05T07:02:37.406302', 'created_date': '2016-06-24'}