Visualizing the innate and adaptive immune responses underlying allograft rejection by two-photon microscopy

Name: Work Video:
Duration: 3 min 30 s
Susanna Celli; Matthew L. Albert; Philippe Bousso
{'id': 'https://openalex.org/W2050570363', 'doi': 'https://doi.org/10.1038/nm.2376', 'title': 'Visualizing the innate and adaptive immune responses underlying allograft rejection by two-photon microscopy', 'display_name': 'Visualizing the innate and adaptive immune responses underlying allograft rejection by two-photon microscopy', 'publication_year': 2011, 'publication_date': '2011-05-15', 'ids': {'openalex': 'https://openalex.org/W2050570363', 'doi': 'https://doi.org/10.1038/nm.2376', 'mag': '2050570363', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21572426'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1038/nm.2376', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S203256638', 'display_name': 'Nature Medicine', 'issn_l': '1078-8956', 'issn': ['1078-8956', '1546-170X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5103556564', 'display_name': 'Susanna Celli', 'orcid': 'https://orcid.org/0000-0002-8296-895X'}, 'institutions': [{'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I157536573', 'display_name': 'Institut Pasteur', 'ror': 'https://ror.org/0495fxg12', 'country_code': 'FR', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I157536573']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Susanna Celli', 'raw_affiliation_strings': ["Département d'Immunologie, Institut Pasteur, Unité des Dynamiques des Réponses Immunes, Paris, France", 'Institut National de la Santé et de la Recherche Médicale (INSERM) U668, Paris, France'], 'affiliations': [{'raw_affiliation_string': 'Institut National de la Santé et de la Recherche Médicale (INSERM) U668, Paris, France', 'institution_ids': ['https://openalex.org/I154526488']}, {'raw_affiliation_string': "Département d'Immunologie, Institut Pasteur, Unité des Dynamiques des Réponses Immunes, Paris, France", 'institution_ids': ['https://openalex.org/I157536573']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5078075662', 'display_name': 'Matthew L. Albert', 'orcid': 'https://orcid.org/0000-0001-7285-6973'}, 'institutions': [{'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I157536573', 'display_name': 'Institut Pasteur', 'ror': 'https://ror.org/0495fxg12', 'country_code': 'FR', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I157536573']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Matthew L Albert', 'raw_affiliation_strings': ['INSERM U818, Paris, France', "Institut Pasteur, Unité d'Immunobiologie des Cellules Dendritiques, Paris, France"], 'affiliations': [{'raw_affiliation_string': 'INSERM U818, Paris, France', 'institution_ids': ['https://openalex.org/I154526488']}, {'raw_affiliation_string': "Institut Pasteur, Unité d'Immunobiologie des Cellules Dendritiques, Paris, France", 'institution_ids': ['https://openalex.org/I157536573']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5039812479', 'display_name': 'Philippe Bousso', 'orcid': 'https://orcid.org/0000-0002-6362-561X'}, 'institutions': [{'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I157536573', 'display_name': 'Institut Pasteur', 'ror': 'https://ror.org/0495fxg12', 'country_code': 'FR', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I157536573']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Philippe Bousso', 'raw_affiliation_strings': ["Département d'Immunologie, Institut Pasteur, Unité des Dynamiques des Réponses Immunes, Paris, France", 'Institut National de la Santé et de la Recherche Médicale (INSERM) U668, Paris, France'], 'affiliations': [{'raw_affiliation_string': 'Institut National de la Santé et de la Recherche Médicale (INSERM) U668, Paris, France', 'institution_ids': ['https://openalex.org/I154526488']}, {'raw_affiliation_string': "Département d'Immunologie, Institut Pasteur, Unité des Dynamiques des Réponses Immunes, Paris, France", 'institution_ids': ['https://openalex.org/I157536573']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 9750, 'currency': 'EUR', 'value_usd': 11690, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 6.681, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 132, 'citation_normalized_percentile': {'value': 0.999922, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '17', 'issue': '6', 'first_page': '744', 'last_page': '749'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10580', 'display_name': 'Immunotherapy and Immune Responses', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10580', 'display_name': 'Immunotherapy and Immune Responses', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10031', 'display_name': 'T-cell and B-cell Immunology', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10725', 'display_name': 'RNA Interference and Gene Delivery', 'score': 0.9955, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/transplant-rejection', 'display_name': 'Transplant rejection', 'score': 0.4427892}], 'concepts': [{'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.6010229}, {'id': 'https://openalex.org/C67662055', 'wikidata': 'https://www.wikidata.org/wiki/Q1047791', 'display_name': 'Antigen-presenting cell', 'level': 4, 'score': 0.55819625}, {'id': 'https://openalex.org/C167672396', 'wikidata': 'https://www.wikidata.org/wiki/Q417800', 'display_name': 'CD8', 'level': 3, 'score': 0.5236285}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.5178428}, {'id': 'https://openalex.org/C83464605', 'wikidata': 'https://www.wikidata.org/wiki/Q575296', 'display_name': 'Antigen presentation', 'level': 4, 'score': 0.51487815}, {'id': 'https://openalex.org/C2780849966', 'wikidata': 'https://www.wikidata.org/wiki/Q170758', 'display_name': 'Lymph node', 'level': 2, 'score': 0.48893705}, {'id': 'https://openalex.org/C193419808', 'wikidata': 'https://www.wikidata.org/wiki/Q1645075', 'display_name': 'Acquired immune system', 'level': 3, 'score': 0.48780683}, {'id': 'https://openalex.org/C2777624698', 'wikidata': 'https://www.wikidata.org/wiki/Q505531', 'display_name': 'Dermis', 'level': 2, 'score': 0.48217076}, {'id': 'https://openalex.org/C147483822', 'wikidata': 'https://www.wikidata.org/wiki/Q103537', 'display_name': 'Antigen', 'level': 2, 'score': 0.46605098}, {'id': 'https://openalex.org/C154317977', 'wikidata': 'https://www.wikidata.org/wiki/Q376266', 'display_name': 'Cytotoxic T cell', 'level': 3, 'score': 0.4516848}, {'id': 'https://openalex.org/C2780179540', 'wikidata': 'https://www.wikidata.org/wiki/Q1765748', 'display_name': 'Transplant rejection', 'level': 3, 'score': 0.4427892}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.43993744}, {'id': 'https://openalex.org/C2776090121', 'wikidata': 'https://www.wikidata.org/wiki/Q193529', 'display_name': 'T cell', 'level': 3, 'score': 0.4164302}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.40932363}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.2947662}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.251006}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.07247004}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D056704', 'descriptor_name': 'Adaptive Immunity', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D006084', 'descriptor_name': 'Graft Rejection', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D007113', 'descriptor_name': 'Immunity, Innate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D036641', 'descriptor_name': 'Microscopy, Fluorescence, Multiphoton', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D016038', 'descriptor_name': 'Skin Transplantation', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D056704', 'descriptor_name': 'Adaptive Immunity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018414', 'descriptor_name': 'CD8-Positive T-Lymphocytes', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D018414', 'descriptor_name': 'CD8-Positive T-Lymphocytes', 'qualifier_ui': 'Q000648', 'qualifier_name': 'ultrastructure', 'is_major_topic': False}, {'descriptor_ui': 'D018414', 'descriptor_name': 'CD8-Positive T-Lymphocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006084', 'descriptor_name': 'Graft Rejection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007801', 'descriptor_name': 'Langerhans Cells', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D007801', 'descriptor_name': 'Langerhans Cells', 'qualifier_ui': 'Q000648', 'qualifier_name': 'ultrastructure', 'is_major_topic': False}, {'descriptor_ui': 'D007801', 'descriptor_name': 'Langerhans Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D036641', 'descriptor_name': 'Microscopy, Fluorescence, Multiphoton', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D012867', 'descriptor_name': 'Skin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012867', 'descriptor_name': 'Skin', 'qualifier_ui': 'Q000648', 'qualifier_name': 'ultrastructure', 'is_major_topic': False}, {'descriptor_ui': 'D012867', 'descriptor_name': 'Skin', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D016038', 'descriptor_name': 'Skin Transplantation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1038/nm.2376', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S203256638', 'display_name': 'Nature Medicine', 'issn_l': '1078-8956', 'issn': ['1078-8956', '1546-170X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/21572426', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.65}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 40, 'referenced_works': ['https://openalex.org/W1882142355', 'https://openalex.org/W1907480148', 'https://openalex.org/W1965065368', 'https://openalex.org/W1969003615', 'https://openalex.org/W1971789451', 'https://openalex.org/W1979358262', 'https://openalex.org/W1979877646', 'https://openalex.org/W1982680586', 'https://openalex.org/W1987481383', 'https://openalex.org/W1995935389', 'https://openalex.org/W2005631373', 'https://openalex.org/W2007412207', 'https://openalex.org/W2012616792', 'https://openalex.org/W2014561104', 'https://openalex.org/W2023037704', 'https://openalex.org/W2028653503', 'https://openalex.org/W2033787149', 'https://openalex.org/W2034619338', 'https://openalex.org/W2036698472', 'https://openalex.org/W2036735368', 'https://openalex.org/W2053685914', 'https://openalex.org/W2056976452', 'https://openalex.org/W2065974926', 'https://openalex.org/W2071205922', 'https://openalex.org/W2072995529', 'https://openalex.org/W2076397065', 'https://openalex.org/W2081712919', 'https://openalex.org/W2083721739', 'https://openalex.org/W2102942510', 'https://openalex.org/W2105932805', 'https://openalex.org/W2117715660', 'https://openalex.org/W2122413738', 'https://openalex.org/W2125600524', 'https://openalex.org/W2131905612', 'https://openalex.org/W213324783', 'https://openalex.org/W2139277639', 'https://openalex.org/W2141102490', 'https://openalex.org/W2155063004', 'https://openalex.org/W2172137324', 'https://openalex.org/W2364455993'], 'related_works': ['https://openalex.org/W55888276', 'https://openalex.org/W4229372160', 'https://openalex.org/W4200444273', 'https://openalex.org/W2417773612', 'https://openalex.org/W2133433794', 'https://openalex.org/W2113289699', 'https://openalex.org/W2061184047', 'https://openalex.org/W2060503948', 'https://openalex.org/W1981986821', 'https://openalex.org/W1432214059'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2050570363', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 10}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 15}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 13}, {'year': 2015, 'cited_by_count': 16}, {'year': 2014, 'cited_by_count': 11}, {'year': 2013, 'cited_by_count': 19}, {'year': 2012, 'cited_by_count': 13}], 'updated_date': '2025-01-15T02:02:32.580464', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
