Title: N‐acetylation genotype and risk of severe reactions to sulphonamides in AIDS patients [letter]
Abstract: British Journal of Clinical PharmacologyVolume 38, Issue 6 p. 581-582 Free Access N-acetylation genotype and risk of severe reactions to sulphonamides in AIDS patients [letter] C Delomenie, C Delomenie Division of Clinical Pharmacology, Glaxo Research and Development Ltd, Greenford, Middlesex.Search for more papers by this authorDM Grant, DM Grant Division of Clinical Pharmacology, Glaxo Research and Development Ltd, Greenford, Middlesex.Search for more papers by this authorP Mathelier-Fusade, P Mathelier-Fusade Division of Clinical Pharmacology, Glaxo Research and Development Ltd, Greenford, Middlesex.Search for more papers by this authorC Jacomet, C Jacomet Division of Clinical Pharmacology, Glaxo Research and Development Ltd, Greenford, Middlesex.Search for more papers by this authorF Leynadier, F Leynadier Division of Clinical Pharmacology, Glaxo Research and Development Ltd, Greenford, Middlesex.Search for more papers by this authorE Jacqz- Aigrain, E Jacqz- Aigrain Division of Clinical Pharmacology, Glaxo Research and Development Ltd, Greenford, Middlesex.Search for more papers by this authorW Rozenbaum, W Rozenbaum Division of Clinical Pharmacology, Glaxo Research and Development Ltd, Greenford, Middlesex.Search for more papers by this authorR Krishnamoorthy, R Krishnamoorthy Division of Clinical Pharmacology, Glaxo Research and Development Ltd, Greenford, Middlesex.Search for more papers by this authorJM Dupret, JM Dupret Division of Clinical Pharmacology, Glaxo Research and Development Ltd, Greenford, Middlesex.Search for more papers by this author C Delomenie, C Delomenie Division of Clinical Pharmacology, Glaxo Research and Development Ltd, Greenford, Middlesex.Search for more papers by this authorDM Grant, DM Grant Division of Clinical Pharmacology, Glaxo Research and Development Ltd, Greenford, Middlesex.Search for more papers by this authorP Mathelier-Fusade, P Mathelier-Fusade Division of Clinical Pharmacology, Glaxo Research and Development Ltd, Greenford, Middlesex.Search for more papers by this authorC Jacomet, C Jacomet Division of Clinical Pharmacology, Glaxo Research and Development Ltd, Greenford, Middlesex.Search for more papers by this authorF Leynadier, F Leynadier Division of Clinical Pharmacology, Glaxo Research and Development Ltd, Greenford, Middlesex.Search for more papers by this authorE Jacqz- Aigrain, E Jacqz- Aigrain Division of Clinical Pharmacology, Glaxo Research and Development Ltd, Greenford, Middlesex.Search for more papers by this authorW Rozenbaum, W Rozenbaum Division of Clinical Pharmacology, Glaxo Research and Development Ltd, Greenford, Middlesex.Search for more papers by this authorR Krishnamoorthy, R Krishnamoorthy Division of Clinical Pharmacology, Glaxo Research and Development Ltd, Greenford, Middlesex.Search for more papers by this authorJM Dupret, JM Dupret Division of Clinical Pharmacology, Glaxo Research and Development Ltd, Greenford, Middlesex.Search for more papers by this author First published: December 1994 https://doi.org/10.1111/j.1365-2125.1994.tb04401.xCitations: 31AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. References 1 Evans DAP. N-acetyltransferase. In Pharmacogenetics of drug metabolism, ed W. Kalow, New York: Pergamon Press, 1992: 95– 178. 2 Shear NH, Spielberg SP, Grant DM, Tang BK, Kalow W. Differences in metabolism of sulfonamides predisposing to idiosyncratic toxicity. Ann intern Med 1986; 105: 179– 184. 3 Gordin FM, Simon GL, Wofsy CB, Mills J. Adverse reactions to trimethoprim-sulfamethoxazole in patients with the acquired immunodeficiency syndrome. Ann intern Med 1984; 100: 495– 499. 4 Lee BL, Wong D., Benowitz NL, Sullam PM. Altered patterns of drug metabolism in patients with acquired immunodeficiency syndrome. Clin Pharmac Ther 1993; 53: 529– 535. 5 Carr A., Gross AS, Hoskins JM, Penny R., Cooper DA. Acetylation phenotype and cutaneous hypersensitivity to trimethoprim-sulphamethoxazole in HIV-infected patients. AIDS 1994; 8: 333– 337. 6 Grant DM. Molecular genetics of the N-acetyltransferases. Pharmacogenetics 1993; 3: 45– 50. Citing Literature Volume38, Issue6December 1994Pages 581-582 ReferencesRelatedInformation