Publication Information

{'id': 'https://openalex.org/W2050389860', 'doi': 'https://doi.org/10.1016/s1535-6108(04)00085-6', 'title': 'Endogenous oncogenic K-rasG12D stimulates proliferation and widespread neoplastic and developmental defects', 'display_name': 'Endogenous oncogenic K-rasG12D stimulates proliferation and widespread neoplastic and developmental defects', 'publication_year': 2004, 'publication_date': '2004-04-01', 'ids': {'openalex': 'https://openalex.org/W2050389860', 'doi': 'https://doi.org/10.1016/s1535-6108(04)00085-6', 'mag': '2050389860', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/15093544'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s1535-6108(04)00085-6', 'pdf_url': 'https://www.cell.com/article/S1535610804000856/pdf', 'source': {'id': 'https://openalex.org/S25671836', 'display_name': 'Cancer Cell', 'issn_l': '1535-6108', 'issn': ['1535-6108', '1878-3686'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315673', 'host_organization_name': 'Cell Press', 'host_organization_lineage': ['https://openalex.org/P4310320990', 'https://openalex.org/P4310315673'], 'host_organization_lineage_names': ['Elsevier BV', 'Cell Press'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.cell.com/article/S1535610804000856/pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5072185005', 'display_name': 'David A. Tuveson', 'orcid': 'https://orcid.org/0000-0002-8017-2712'}, 'institutions': [{'id': 'https://openalex.org/I4210128526', 'display_name': 'UPMC Hillman Cancer Center', 'ror': 'https://ror.org/03bw34a45', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I170201317', 'https://openalex.org/I4210128526']}, {'id': 'https://openalex.org/I169071179', 'display_name': 'Cancer Research Institute', 'ror': 'https://ror.org/02f3xk561', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I169071179']}, {'id': 'https://openalex.org/I79576946', 'display_name': 'University of Pennsylvania', 'ror': 'https://ror.org/00b30xv10', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I79576946']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'David A Tuveson', 'raw_affiliation_strings': ['Abramson Family Cancer Research Institute, Abramson Cancer Center and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104 USA'], 'affiliations': [{'raw_affiliation_string': 'Abramson Family Cancer Research Institute, Abramson Cancer Center and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104 USA', 'institution_ids': ['https://openalex.org/I4210128526', 'https://openalex.org/I169071179', 'https://openalex.org/I79576946']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080311196', 'display_name': 'Alice T. Shaw', 'orcid': 'https://orcid.org/0000-0001-6337-1093'}, 'institutions': [{'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}, {'id': 'https://openalex.org/I4210110987', 'display_name': 'IIT@MIT', 'ror': 'https://ror.org/01wp8zh54', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I30771326', 'https://openalex.org/I4210110987']}, {'id': 'https://openalex.org/I1344073410', 'display_name': 'Howard Hughes Medical Institute', 'ror': 'https://ror.org/006w34k90', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1344073410']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Alice T Shaw', 'raw_affiliation_strings': ['Department of Adult Oncology, Dana-Farber Cancer Institute, Boston, MA 02115 USA', 'Howard Hughes Medical Institute at MIT, Cambridge, MA 02139 USA', 'MIT Cancer Center and Department of Biology, Cambridge, MA 02139 USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Adult Oncology, Dana-Farber Cancer Institute, Boston, MA 02115 USA', 'institution_ids': ['https://openalex.org/I4210117453']}, {'raw_affiliation_string': 'MIT Cancer Center and Department of Biology, Cambridge, MA 02139 USA', 'institution_ids': ['https://openalex.org/I4210110987']}, {'raw_affiliation_string': 'Howard Hughes Medical Institute at MIT, Cambridge, MA 02139 USA', 'institution_ids': ['https://openalex.org/I1344073410']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022361220', 'display_name': 'Nicholas A. Willis', 'orcid': 'https://orcid.org/0000-0003-2091-5462'}, 'institutions': [{'id': 'https://openalex.org/I1344073410', 'display_name': 'Howard Hughes Medical Institute', 'ror': 'https://ror.org/006w34k90', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1344073410']}, {'id': 'https://openalex.org/I4210110987', 'display_name': 'IIT@MIT', 'ror': 'https://ror.org/01wp8zh54', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I30771326', 'https://openalex.org/I4210110987']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Nicholas A Willis', 'raw_affiliation_strings': ['Howard Hughes Medical Institute at MIT, Cambridge, MA 02139 USA', 'MIT Cancer Center and Department of Biology, Cambridge, MA 02139 USA'], 'affiliations': [{'raw_affiliation_string': 'Howard Hughes Medical Institute at MIT, Cambridge, MA 02139 USA', 'institution_ids': ['https://openalex.org/I1344073410']}, {'raw_affiliation_string': 'MIT Cancer Center and Department of Biology, Cambridge, MA 02139 USA', 'institution_ids': ['https://openalex.org/I4210110987']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030179640', 'display_name': 'Daniel P. Silver', 'orcid': 'https://orcid.org/0000-0003-3771-806X'}, 'institutions': [{'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Daniel P Silver', 'raw_affiliation_strings': ['Department of Adult Oncology, Dana-Farber Cancer Institute, Boston, MA 02115 USA', 'Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115 USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Adult Oncology, Dana-Farber Cancer Institute, Boston, MA 02115 USA', 'institution_ids': ['https://openalex.org/I4210117453']}, {'raw_affiliation_string': 'Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115 USA', 'institution_ids': ['https://openalex.org/I4210117453']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091083024', 'display_name': 'Erica L. Jackson', 'orcid': 'https://orcid.org/0000-0002-7100-8021'}, 'institutions': [{'id': 'https://openalex.org/I4210110987', 'display_name': 'IIT@MIT', 'ror': 'https://ror.org/01wp8zh54', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I30771326', 'https://openalex.org/I4210110987']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Erica L Jackson', 'raw_affiliation_strings': ['MIT Cancer Center and Department of Biology, Cambridge, MA 02139 USA'], 'affiliations': [{'raw_affiliation_string': 'MIT Cancer Center and Department of Biology, Cambridge, MA 02139 USA', 'institution_ids': ['https://openalex.org/I4210110987']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089335852', 'display_name': 'Sandy Chang', 'orcid': 'https://orcid.org/0000-0002-9560-1671'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sandy Chang', 'raw_affiliation_strings': ['Department of Molecular Genetics, MD Anderson Cancer Center, Houston, TX 77030 USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Genetics, MD Anderson Cancer Center, Houston, TX 77030 USA', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004567701', 'display_name': 'Kim L. Mercer', 'orcid': 'https://orcid.org/0000-0002-8525-483X'}, 'institutions': [{'id': 'https://openalex.org/I4210110987', 'display_name': 'IIT@MIT', 'ror': 'https://ror.org/01wp8zh54', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I30771326', 'https://openalex.org/I4210110987']}, {'id': 'https://openalex.org/I1344073410', 'display_name': 'Howard Hughes Medical Institute', 'ror': 'https://ror.org/006w34k90', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1344073410']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kim L Mercer', 'raw_affiliation_strings': ['Howard Hughes Medical Institute at MIT, Cambridge, MA 02139 USA', 'MIT Cancer Center and Department of Biology, Cambridge, MA 02139 USA'], 'affiliations': [{'raw_affiliation_string': 'MIT Cancer Center and Department of Biology, Cambridge, MA 02139 USA', 'institution_ids': ['https://openalex.org/I4210110987']}, {'raw_affiliation_string': 'Howard Hughes Medical Institute at MIT, Cambridge, MA 02139 USA', 'institution_ids': ['https://openalex.org/I1344073410']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110217348', 'display_name': 'Rebecca Grochow', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210110987', 'display_name': 'IIT@MIT', 'ror': 'https://ror.org/01wp8zh54', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I30771326', 'https://openalex.org/I4210110987']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Rebecca Grochow', 'raw_affiliation_strings': ['MIT Cancer Center and Department of Biology, Cambridge, MA 02139 USA'], 'affiliations': [{'raw_affiliation_string': 'MIT Cancer Center and Department of Biology, Cambridge, MA 02139 USA', 'institution_ids': ['https://openalex.org/I4210110987']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5081051762', 'display_name': 'Hanno Hock', 'orcid': 'https://orcid.org/0000-0002-5201-9403'}, 'institutions': [{'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Hanno Hock', 'raw_affiliation_strings': ['Department of Adult Oncology, Dana-Farber Cancer Institute, Boston, MA 02115 USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Adult Oncology, Dana-Farber Cancer Institute, Boston, MA 02115 USA', 'institution_ids': ['https://openalex.org/I4210117453']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111449341', 'display_name': 'Denise Crowley', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210110987', 'display_name': 'IIT@MIT', 'ror': 'https://ror.org/01wp8zh54', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I30771326', 'https://openalex.org/I4210110987']}, {'id': 'https://openalex.org/I1344073410', 'display_name': 'Howard Hughes Medical Institute', 'ror': 'https://ror.org/006w34k90', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1344073410']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Denise Crowley', 'raw_affiliation_strings': ['Howard Hughes Medical Institute at MIT, Cambridge, MA 02139 USA', 'MIT Cancer Center and Department of Biology, Cambridge, MA 02139 USA'], 'affiliations': [{'raw_affiliation_string': 'MIT Cancer Center and Department of Biology, Cambridge, MA 02139 USA', 'institution_ids': ['https://openalex.org/I4210110987']}, {'raw_affiliation_string': 'Howard Hughes Medical Institute at MIT, Cambridge, MA 02139 USA', 'institution_ids': ['https://openalex.org/I1344073410']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013925502', 'display_name': 'Sunil R. Hingorani', 'orcid': 'https://orcid.org/0000-0002-3869-8729'}, 'institutions': [{'id': 'https://openalex.org/I169071179', 'display_name': 'Cancer Research Institute', 'ror': 'https://ror.org/02f3xk561', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I169071179']}, {'id': 'https://openalex.org/I79576946', 'display_name': 'University of Pennsylvania', 'ror': 'https://ror.org/00b30xv10', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I79576946']}, {'id': 'https://openalex.org/I4210128526', 'display_name': 'UPMC Hillman Cancer Center', 'ror': 'https://ror.org/03bw34a45', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I170201317', 'https://openalex.org/I4210128526']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sunil R Hingorani', 'raw_affiliation_strings': ['Abramson Family Cancer Research Institute, Abramson Cancer Center and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104 USA'], 'affiliations': [{'raw_affiliation_string': 'Abramson Family Cancer Research Institute, Abramson Cancer Center and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104 USA', 'institution_ids': ['https://openalex.org/I169071179', 'https://openalex.org/I79576946', 'https://openalex.org/I4210128526']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088917458', 'display_name': 'Tal Zaks', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I169071179', 'display_name': 'Cancer Research Institute', 'ror': 'https://ror.org/02f3xk561', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I169071179']}, {'id': 'https://openalex.org/I79576946', 'display_name': 'University of Pennsylvania', 'ror': 'https://ror.org/00b30xv10', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I79576946']}, {'id': 'https://openalex.org/I4210128526', 'display_name': 'UPMC Hillman Cancer Center', 'ror': 'https://ror.org/03bw34a45', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I170201317', 'https://openalex.org/I4210128526']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Tal Zaks', 'raw_affiliation_strings': ['Abramson Family Cancer Research Institute, Abramson Cancer Center and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104 USA'], 'affiliations': [{'raw_affiliation_string': 'Abramson Family Cancer Research Institute, Abramson Cancer Center and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104 USA', 'institution_ids': ['https://openalex.org/I169071179', 'https://openalex.org/I79576946', 'https://openalex.org/I4210128526']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108627948', 'display_name': 'Catrina E. King', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I169071179', 'display_name': 'Cancer Research Institute', 'ror': 'https://ror.org/02f3xk561', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I169071179']}, {'id': 'https://openalex.org/I79576946', 'display_name': 'University of Pennsylvania', 'ror': 'https://ror.org/00b30xv10', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I79576946']}, {'id': 'https://openalex.org/I4210128526', 'display_name': 'UPMC Hillman Cancer Center', 'ror': 'https://ror.org/03bw34a45', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I170201317', 'https://openalex.org/I4210128526']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Catrina King', 'raw_affiliation_strings': ['Abramson Family Cancer Research Institute, Abramson Cancer Center and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104 USA'], 'affiliations': [{'raw_affiliation_string': 'Abramson Family Cancer Research Institute, Abramson Cancer Center and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104 USA', 'institution_ids': ['https://openalex.org/I169071179', 'https://openalex.org/I79576946', 'https://openalex.org/I4210128526']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075349669', 'display_name': 'Michael A. Jacobetz', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I169071179', 'display_name': 'Cancer Research Institute', 'ror': 'https://ror.org/02f3xk561', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I169071179']}, {'id': 'https://openalex.org/I79576946', 'display_name': 'University of Pennsylvania', 'ror': 'https://ror.org/00b30xv10', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I79576946']}, {'id': 'https://openalex.org/I4210128526', 'display_name': 'UPMC Hillman Cancer Center', 'ror': 'https://ror.org/03bw34a45', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I170201317', 'https://openalex.org/I4210128526']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Michael A Jacobetz', 'raw_affiliation_strings': ['Abramson Family Cancer Research Institute, Abramson Cancer Center and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104 USA'], 'affiliations': [{'raw_affiliation_string': 'Abramson Family Cancer Research Institute, Abramson Cancer Center and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104 USA', 'institution_ids': ['https://openalex.org/I169071179', 'https://openalex.org/I79576946', 'https://openalex.org/I4210128526']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101922066', 'display_name': 'Lifu Wang', 'orcid': 'https://orcid.org/0000-0001-5172-9932'}, 'institutions': [{'id': 'https://openalex.org/I169071179', 'display_name': 'Cancer Research Institute', 'ror': 'https://ror.org/02f3xk561', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I169071179']}, {'id': 'https://openalex.org/I79576946', 'display_name': 'University of Pennsylvania', 'ror': 'https://ror.org/00b30xv10', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I79576946']}, {'id': 'https://openalex.org/I4210128526', 'display_name': 'UPMC Hillman Cancer Center', 'ror': 'https://ror.org/03bw34a45', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I170201317', 'https://openalex.org/I4210128526']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Lifu Wang', 'raw_affiliation_strings': ['Abramson Family Cancer Research Institute, Abramson Cancer Center and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104 USA'], 'affiliations': [{'raw_affiliation_string': 'Abramson Family Cancer Research Institute, Abramson Cancer Center and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104 USA', 'institution_ids': ['https://openalex.org/I169071179', 'https://openalex.org/I79576946', 'https://openalex.org/I4210128526']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054412365', 'display_name': 'Roderick T. Bronson', 'orcid': 'https://orcid.org/0000-0003-3725-2511'}, 'institutions': [{'id': 'https://openalex.org/I121934306', 'display_name': 'Tufts University', 'ror': 'https://ror.org/05wvpxv85', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I121934306']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Roderick T Bronson', 'raw_affiliation_strings': ['Department of Pathology, Tufts University School of Medicine and Veterinary Medicine, Boston, MA 02111 USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, Tufts University School of Medicine and Veterinary Medicine, Boston, MA 02111 USA', 'institution_ids': ['https://openalex.org/I121934306']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079784932', 'display_name': 'Stuart H. Orkin', 'orcid': 'https://orcid.org/0000-0002-0313-152X'}, 'institutions': [{'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}, {'id': 'https://openalex.org/I1344073410', 'display_name': 'Howard Hughes Medical Institute', 'ror': 'https://ror.org/006w34k90', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1344073410']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Stuart H Orkin', 'raw_affiliation_strings': ['Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02115 USA', "Howard Hughes Medical Institute at Children's Hospital, Boston, MA 02115 USA"], 'affiliations': [{'raw_affiliation_string': 'Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02115 USA', 'institution_ids': ['https://openalex.org/I4210117453']}, {'raw_affiliation_string': "Howard Hughes Medical Institute at Children's Hospital, Boston, MA 02115 USA", 'institution_ids': ['https://openalex.org/I1344073410']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008120994', 'display_name': 'Ronald A. DePinho', 'orcid': 'https://orcid.org/0000-0002-5625-577X'}, 'institutions': [{'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ronald A DePinho', 'raw_affiliation_strings': ['Department of Adult Oncology, Dana-Farber Cancer Institute, Boston, MA 02115 USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Adult Oncology, Dana-Farber Cancer Institute, Boston, MA 02115 USA', 'institution_ids': ['https://openalex.org/I4210117453']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5071936673', 'display_name': 'Tyler Jacks', 'orcid': 'https://orcid.org/0000-0001-5785-8911'}, 'institutions': [{'id': 'https://openalex.org/I4210110987', 'display_name': 'IIT@MIT', 'ror': 'https://ror.org/01wp8zh54', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I30771326', 'https://openalex.org/I4210110987']}, {'id': 'https://openalex.org/I1344073410', 'display_name': 'Howard Hughes Medical Institute', 'ror': 'https://ror.org/006w34k90', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1344073410']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Tyler Jacks', 'raw_affiliation_strings': ['Howard Hughes Medical Institute at MIT, Cambridge, MA 02139 USA', 'MIT Cancer Center and Department of Biology, Cambridge, MA 02139 USA'], 'affiliations': [{'raw_affiliation_string': 'MIT Cancer Center and Department of Biology, Cambridge, MA 02139 USA', 'institution_ids': ['https://openalex.org/I4210110987']}, {'raw_affiliation_string': 'Howard Hughes Medical Institute at MIT, Cambridge, MA 02139 USA', 'institution_ids': ['https://openalex.org/I1344073410']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 8, 'corresponding_author_ids': ['https://openalex.org/A5071936673'], 'corresponding_institution_ids': ['https://openalex.org/I4210110987', 'https://openalex.org/I1344073410'], 'apc_list': {'value': 9080, 'currency': 'USD', 'value_usd': 9080, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 14.494, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 780, 'citation_normalized_percentile': {'value': 0.999979, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '5', 'issue': '4', 'first_page': '375', 'last_page': '387'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10583', 'display_name': 'Cancer-related Molecular Pathways', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10583', 'display_name': 'Cancer-related Molecular Pathways', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10294', 'display_name': 'Cell death mechanisms and regulation', 'score': 0.9982, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10231', 'display_name': 'Pancreatic and Hepatic Oncology Research', 'score': 0.9973, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/malignant-transformation', 'display_name': 'Malignant Transformation', 'score': 0.5677709}, {'id': 'https://openalex.org/keywords/neoplastic-transformation', 'display_name': 'Neoplastic transformation', 'score': 0.46334016}], 'concepts': [{'id': 'https://openalex.org/C16613235', 'wikidata': 'https://www.wikidata.org/wiki/Q285982', 'display_name': 'Endogeny', 'level': 2, 'score': 0.7985618}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.67674947}, {'id': 'https://openalex.org/C2781018059', 'wikidata': 'https://www.wikidata.org/wiki/Q207609', 'display_name': 'Oncogene', 'level': 4, 'score': 0.59061986}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.58831733}, {'id': 'https://openalex.org/C31033888', 'wikidata': 'https://www.wikidata.org/wiki/Q752076', 'display_name': 'Malignant transformation', 'level': 2, 'score': 0.5677709}, {'id': 'https://openalex.org/C62112901', 'wikidata': 'https://www.wikidata.org/wiki/Q189159', 'display_name': 'Cell growth', 'level': 2, 'score': 0.5602719}, {'id': 'https://openalex.org/C51785407', 'wikidata': 'https://www.wikidata.org/wiki/Q2627568', 'display_name': 'Effector', 'level': 2, 'score': 0.5455879}, {'id': 'https://openalex.org/C555283112', 'wikidata': 'https://www.wikidata.org/wiki/Q1637543', 'display_name': 'Carcinogenesis', 'level': 3, 'score': 0.54195243}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.49254307}, {'id': 'https://openalex.org/C145103041', 'wikidata': 'https://www.wikidata.org/wiki/Q1151519', 'display_name': 'Embryonic stem cell', 'level': 3, 'score': 0.47521004}, {'id': 'https://openalex.org/C2993273003', 'wikidata': 'https://www.wikidata.org/wiki/Q1637543', 'display_name': 'Neoplastic transformation', 'level': 4, 'score': 0.46334016}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.4143887}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.31871292}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.29081035}, {'id': 'https://openalex.org/C29537977', 'wikidata': 'https://www.wikidata.org/wiki/Q188941', 'display_name': 'Cell cycle', 'level': 3, 'score': 0.26891202}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.15170866}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.14839432}], 'mesh': [{'descriptor_ui': 'D002471', 'descriptor_name': 'Cell Transformation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000013', 'descriptor_name': 'Congenital Abnormalities', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D005347', 'descriptor_name': 'Fibroblasts', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D018507', 'descriptor_name': 'Gene Expression Regulation, Developmental', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D011905', 'descriptor_name': 'Genes, ras', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002453', 'descriptor_name': 'Cell Cycle', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002455', 'descriptor_name': 'Cell Division', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016922', 'descriptor_name': 'Cellular Senescence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000013', 'descriptor_name': 'Congenital Abnormalities', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D000013', 'descriptor_name': 'Congenital Abnormalities', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003433', 'descriptor_name': 'Crosses, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019941', 'descriptor_name': 'Cyclin-Dependent Kinase Inhibitor p16', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004622', 'descriptor_name': 'Embryo, Mammalian', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D004622', 'descriptor_name': 'Embryo, Mammalian', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005347', 'descriptor_name': 'Fibroblasts', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005347', 'descriptor_name': 'Fibroblasts', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018507', 'descriptor_name': 'Gene Expression Regulation, Developmental', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011905', 'descriptor_name': 'Genes, ras', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019426', 'descriptor_name': 'Integrases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D019426', 'descriptor_name': 'Integrases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008822', 'descriptor_name': 'Mice, Transgenic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013234', 'descriptor_name': 'Stem Cells', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D013234', 'descriptor_name': 'Stem Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D025803', 'descriptor_name': 'Tumor Suppressor Protein p14ARF', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D025803', 'descriptor_name': 'Tumor Suppressor Protein p14ARF', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D025803', 'descriptor_name': 'Tumor Suppressor Protein p14ARF', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016159', 'descriptor_name': 'Tumor Suppressor Protein p53', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D016159', 'descriptor_name': 'Tumor Suppressor Protein p53', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016159', 'descriptor_name': 'Tumor Suppressor Protein p53', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014764', 'descriptor_name': 'Viral Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014764', 'descriptor_name': 'Viral Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s1535-6108(04)00085-6', 'pdf_url': 'https://www.cell.com/article/S1535610804000856/pdf', 'source': {'id': 'https://openalex.org/S25671836', 'display_name': 'Cancer Cell', 'issn_l': '1535-6108', 'issn': ['1535-6108', '1878-3686'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315673', 'host_organization_name': 'Cell Press', 'host_organization_lineage': ['https://openalex.org/P4310320990', 'https://openalex.org/P4310315673'], 'host_organization_lineage_names': ['Elsevier BV', 'Cell Press'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/15093544', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s1535-6108(04)00085-6', 'pdf_url': 'https://www.cell.com/article/S1535610804000856/pdf', 'source': {'id': 'https://openalex.org/S25671836', 'display_name': 'Cancer Cell', 'issn_l': '1535-6108', 'issn': ['1535-6108', '1878-3686'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315673', 'host_organization_name': 'Cell Press', 'host_organization_lineage': ['https://openalex.org/P4310320990', 'https://openalex.org/P4310315673'], 'host_organization_lineage_names': ['Elsevier BV', 'Cell Press'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.58, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 49, 'referenced_works': ['https://openalex.org/W1611210979', 'https://openalex.org/W1845790496', 'https://openalex.org/W1966453709', 'https://openalex.org/W1968963646', 'https://openalex.org/W1973677994', 'https://openalex.org/W1973886069', 'https://openalex.org/W1974747739', 'https://openalex.org/W1980981080', 'https://openalex.org/W1983751803', 'https://openalex.org/W1984948591', 'https://openalex.org/W1989009382', 'https://openalex.org/W1994772304', 'https://openalex.org/W2000099020', 'https://openalex.org/W2009235369', 'https://openalex.org/W2010161234', 'https://openalex.org/W2014356084', 'https://openalex.org/W2017235640', 'https://openalex.org/W2017349699', 'https://openalex.org/W2026039004', 'https://openalex.org/W2027345413', 'https://openalex.org/W2033417996', 'https://openalex.org/W2039463309', 'https://openalex.org/W2042796276', 'https://openalex.org/W2046958356', 'https://openalex.org/W2049085719', 'https://openalex.org/W2049452540', 'https://openalex.org/W2051593267', 'https://openalex.org/W2055917628', 'https://openalex.org/W2066135299', 'https://openalex.org/W2077297619', 'https://openalex.org/W2081779271', 'https://openalex.org/W2083695927', 'https://openalex.org/W2087404852', 'https://openalex.org/W2097358179', 'https://openalex.org/W2098294628', 'https://openalex.org/W2100876151', 'https://openalex.org/W2104775085', 'https://openalex.org/W2104908670', 'https://openalex.org/W2117079180', 'https://openalex.org/W2125547572', 'https://openalex.org/W2131675463', 'https://openalex.org/W2141529421', 'https://openalex.org/W2147839086', 'https://openalex.org/W2153787194', 'https://openalex.org/W2159594827', 'https://openalex.org/W2164454429', 'https://openalex.org/W2306594860', 'https://openalex.org/W2463877885', 'https://openalex.org/W4251068277'], 'related_works': ['https://openalex.org/W4320492283', 'https://openalex.org/W4309090929', 'https://openalex.org/W4214695225', 'https://openalex.org/W3197607994', 'https://openalex.org/W2783284266', 'https://openalex.org/W2418391677', 'https://openalex.org/W2232494155', 'https://openalex.org/W2036374110', 'https://openalex.org/W1530034981', 'https://openalex.org/W1034346310'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2050389860', 'counts_by_year': [{'year': 2024, 'cited_by_count': 23}, {'year': 2023, 'cited_by_count': 25}, {'year': 2022, 'cited_by_count': 30}, {'year': 2021, 'cited_by_count': 44}, {'year': 2020, 'cited_by_count': 30}, {'year': 2019, 'cited_by_count': 37}, {'year': 2018, 'cited_by_count': 31}, {'year': 2017, 'cited_by_count': 33}, {'year': 2016, 'cited_by_count': 41}, {'year': 2015, 'cited_by_count': 39}, {'year': 2014, 'cited_by_count': 48}, {'year': 2013, 'cited_by_count': 45}, {'year': 2012, 'cited_by_count': 48}], 'updated_date': '2025-01-11T09:10:35.009615', 'created_date': '2016-06-24'}