Publication Information

{'id': 'https://openalex.org/W2050355159', 'doi': 'https://doi.org/10.1074/jbc.m808762200', 'title': 'Rapid Optimization of a Peptide Inhibitor of Malaria Parasite Invasion by Comprehensive N-Methyl Scanning', 'display_name': 'Rapid Optimization of a Peptide Inhibitor of Malaria Parasite Invasion by Comprehensive N-Methyl Scanning', 'publication_year': 2009, 'publication_date': '2009-01-23', 'ids': {'openalex': 'https://openalex.org/W2050355159', 'doi': 'https://doi.org/10.1074/jbc.m808762200', 'mag': '2050355159', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/19164290', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2666588'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m808762200', 'pdf_url': 'http://www.jbc.org/article/S0021925820323346/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S0021925820323346/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5051054347', 'display_name': 'Karen S. Harris', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I196829312', 'display_name': 'La Trobe University', 'ror': 'https://ror.org/01rxfrp27', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I196829312']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Karen S. Harris', 'raw_affiliation_strings': ['Department of Biochemistry, La Trobe University, Victoria 3086'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, La Trobe University, Victoria 3086', 'institution_ids': ['https://openalex.org/I196829312']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110234290', 'display_name': 'Joanne L. Casey', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I196829312', 'display_name': 'La Trobe University', 'ror': 'https://ror.org/01rxfrp27', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I196829312']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Joanne L. Casey', 'raw_affiliation_strings': ['AdAlta Pty. Ltd., 15/2 Park Drive, Bundoora, Victoria 3083', 'Department of Biochemistry, La Trobe University, Victoria 3086'], 'affiliations': [{'raw_affiliation_string': 'AdAlta Pty. Ltd., 15/2 Park Drive, Bundoora, Victoria 3083', 'institution_ids': []}, {'raw_affiliation_string': 'Department of Biochemistry, La Trobe University, Victoria 3086', 'institution_ids': ['https://openalex.org/I196829312']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035734343', 'display_name': 'Andrew M. Coley', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I196829312', 'display_name': 'La Trobe University', 'ror': 'https://ror.org/01rxfrp27', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I196829312']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Andrew M. Coley', 'raw_affiliation_strings': ['Department of Biochemistry, La Trobe University, Victoria 3086'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, La Trobe University, Victoria 3086', 'institution_ids': ['https://openalex.org/I196829312']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038193913', 'display_name': 'John A. Karas', 'orcid': 'https://orcid.org/0000-0002-3800-5152'}, 'institutions': [{'id': 'https://openalex.org/I165779595', 'display_name': 'University of Melbourne', 'ror': 'https://ror.org/01ej9dk98', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I165779595']}, {'id': 'https://openalex.org/I1312106833', 'display_name': 'Biotechnology Institute', 'ror': 'https://ror.org/00s1jty20', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1312106833']}], 'countries': ['AU', 'US'], 'is_corresponding': False, 'raw_author_name': 'John A. Karas', 'raw_affiliation_strings': ['BIO21 Molecular Science and Biotechnology Institute, The University of Melbourne, 30 Flemington Road, Parkville, Victoria 3010'], 'affiliations': [{'raw_affiliation_string': 'BIO21 Molecular Science and Biotechnology Institute, The University of Melbourne, 30 Flemington Road, Parkville, Victoria 3010', 'institution_ids': ['https://openalex.org/I165779595', 'https://openalex.org/I1312106833']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029583895', 'display_name': 'Jennifer K. Sabo', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I196021976', 'display_name': 'Walter and Eliza Hall Institute of Medical Research', 'ror': 'https://ror.org/01b6kha49', 'country_code': 'AU', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I196021976']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Jennifer K. Sabo', 'raw_affiliation_strings': ['Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050'], 'affiliations': [{'raw_affiliation_string': 'Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050', 'institution_ids': ['https://openalex.org/I196021976']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005568443', 'display_name': 'Yen Yee Tan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I196021976', 'display_name': 'Walter and Eliza Hall Institute of Medical Research', 'ror': 'https://ror.org/01b6kha49', 'country_code': 'AU', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I196021976']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Yen Yee Tan', 'raw_affiliation_strings': ['Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050'], 'affiliations': [{'raw_affiliation_string': 'Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050', 'institution_ids': ['https://openalex.org/I196021976']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064765797', 'display_name': 'Olan Dolezal', 'orcid': 'https://orcid.org/0000-0002-5823-6978'}, 'institutions': [{'id': 'https://openalex.org/I1292875679', 'display_name': 'Commonwealth Scientific and Industrial Research Organisation', 'ror': 'https://ror.org/03qn8fb07', 'country_code': 'AU', 'type': 'government', 'lineage': ['https://openalex.org/I1292875679', 'https://openalex.org/I2801453606', 'https://openalex.org/I4387156119']}, {'id': 'https://openalex.org/I4210097193', 'display_name': 'Technologies pour la Santé', 'ror': 'https://ror.org/012hpz460', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488', 'https://openalex.org/I4210097193']}], 'countries': ['AU', 'FR'], 'is_corresponding': False, 'raw_author_name': 'Olan Dolezal', 'raw_affiliation_strings': ['CSIRO Molecular and Health Technologies, 343 Royal Parade, Parkville, Victoria 3052'], 'affiliations': [{'raw_affiliation_string': 'CSIRO Molecular and Health Technologies, 343 Royal Parade, Parkville, Victoria 3052', 'institution_ids': ['https://openalex.org/I1292875679', 'https://openalex.org/I4210097193']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5039797008', 'display_name': 'Raymond S. Norton', 'orcid': 'https://orcid.org/0000-0001-8893-0584'}, 'institutions': [{'id': 'https://openalex.org/I196021976', 'display_name': 'Walter and Eliza Hall Institute of Medical Research', 'ror': 'https://ror.org/01b6kha49', 'country_code': 'AU', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I196021976']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Raymond S. Norton', 'raw_affiliation_strings': ['Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050'], 'affiliations': [{'raw_affiliation_string': 'Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050', 'institution_ids': ['https://openalex.org/I196021976']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032572170', 'display_name': 'Andrew B. Hughes', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I196829312', 'display_name': 'La Trobe University', 'ror': 'https://ror.org/01rxfrp27', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I196829312']}], 'countries': ['AU'], 'is_corresponding': True, 'raw_author_name': 'Andrew B. Hughes', 'raw_affiliation_strings': ['Department of Chemistry, La Trobe University, Victoria 3086, Australia'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry, La Trobe University, Victoria 3086, Australia', 'institution_ids': ['https://openalex.org/I196829312']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5014978932', 'display_name': 'Denis B. Scanlon', 'orcid': 'https://orcid.org/0000-0003-0960-8197'}, 'institutions': [{'id': 'https://openalex.org/I1312106833', 'display_name': 'Biotechnology Institute', 'ror': 'https://ror.org/00s1jty20', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1312106833']}, {'id': 'https://openalex.org/I165779595', 'display_name': 'University of Melbourne', 'ror': 'https://ror.org/01ej9dk98', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I165779595']}], 'countries': ['AU', 'US'], 'is_corresponding': False, 'raw_author_name': 'Denis Scanlon', 'raw_affiliation_strings': ['BIO21 Molecular Science and Biotechnology Institute, The University of Melbourne, 30 Flemington Road, Parkville, Victoria 3010'], 'affiliations': [{'raw_affiliation_string': 'BIO21 Molecular Science and Biotechnology Institute, The University of Melbourne, 30 Flemington Road, Parkville, Victoria 3010', 'institution_ids': ['https://openalex.org/I1312106833', 'https://openalex.org/I165779595']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5088928746', 'display_name': 'Michael Foley', 'orcid': 'https://orcid.org/0000-0003-1349-4698'}, 'institutions': [{'id': 'https://openalex.org/I196829312', 'display_name': 'La Trobe University', 'ror': 'https://ror.org/01rxfrp27', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I196829312']}], 'countries': ['AU'], 'is_corresponding': True, 'raw_author_name': 'Michael Foley', 'raw_affiliation_strings': ['AdAlta Pty. Ltd., 15/2 Park Drive, Bundoora, Victoria 3083', 'Department of Biochemistry, La Trobe University, Victoria 3086'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, La Trobe University, Victoria 3086', 'institution_ids': ['https://openalex.org/I196829312']}, {'raw_affiliation_string': 'AdAlta Pty. Ltd., 15/2 Park Drive, Bundoora, Victoria 3083', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 6, 'corresponding_author_ids': ['https://openalex.org/A5032572170', 'https://openalex.org/A5088928746'], 'corresponding_institution_ids': ['https://openalex.org/I196829312', 'https://openalex.org/I196829312'], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 3.056, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 60, 'citation_normalized_percentile': {'value': 0.918299, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '284', 'issue': '14', 'first_page': '9361', 'last_page': '9371'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12576', 'display_name': 'vaccines and immunoinformatics approaches', 'score': 0.9971, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12576', 'display_name': 'vaccines and immunoinformatics approaches', 'score': 0.9971, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10091', 'display_name': 'Malaria Research and Control', 'score': 0.9938, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10911', 'display_name': 'Chemical Synthesis and Analysis', 'score': 0.9933, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/proteolytic-enzymes', 'display_name': 'Proteolytic enzymes', 'score': 0.47265685}, {'id': 'https://openalex.org/keywords/proteolysis', 'display_name': 'Proteolysis', 'score': 0.43567315}], 'concepts': [{'id': 'https://openalex.org/C2779281246', 'wikidata': 'https://www.wikidata.org/wiki/Q172847', 'display_name': 'Peptide', 'level': 2, 'score': 0.8564375}, {'id': 'https://openalex.org/C2778371730', 'wikidata': 'https://www.wikidata.org/wiki/Q311383', 'display_name': 'Plasmodium falciparum', 'level': 3, 'score': 0.70672774}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.59784794}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5214733}, {'id': 'https://openalex.org/C33288867', 'wikidata': 'https://www.wikidata.org/wiki/Q518328', 'display_name': 'Methylation', 'level': 3, 'score': 0.48814282}, {'id': 'https://openalex.org/C3019223276', 'wikidata': 'https://www.wikidata.org/wiki/Q212410', 'display_name': 'Proteolytic enzymes', 'level': 3, 'score': 0.47265685}, {'id': 'https://openalex.org/C2781307694', 'wikidata': 'https://www.wikidata.org/wiki/Q33123', 'display_name': 'Proteolysis', 'level': 3, 'score': 0.43567315}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.35514608}, {'id': 'https://openalex.org/C2778048844', 'wikidata': 'https://www.wikidata.org/wiki/Q12156', 'display_name': 'Malaria', 'level': 2, 'score': 0.26667514}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.17568079}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.092982024}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000962', 'descriptor_name': 'Antimalarials', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D010963', 'descriptor_name': 'Plasmodium falciparum', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000962', 'descriptor_name': 'Antimalarials', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D000962', 'descriptor_name': 'Antimalarials', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008745', 'descriptor_name': 'Methylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019906', 'descriptor_name': 'Nuclear Magnetic Resonance, Biomolecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010963', 'descriptor_name': 'Plasmodium falciparum', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013379', 'descriptor_name': 'Substrate Specificity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020349', 'descriptor_name': 'Surface Plasmon Resonance', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m808762200', 'pdf_url': 'http://www.jbc.org/article/S0021925820323346/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2666588', 'pdf_url': 'https://europepmc.org/articles/pmc2666588?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2666588', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/19164290', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m808762200', 'pdf_url': 'http://www.jbc.org/article/S0021925820323346/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.82, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 58, 'referenced_works': ['https://openalex.org/W104821597', 'https://openalex.org/W1264065055', 'https://openalex.org/W1603437828', 'https://openalex.org/W1904694837', 'https://openalex.org/W1967081540', 'https://openalex.org/W1968084203', 'https://openalex.org/W1969503178', 'https://openalex.org/W1970994789', 'https://openalex.org/W1972459558', 'https://openalex.org/W1978408831', 'https://openalex.org/W1983880435', 'https://openalex.org/W1984766543', 'https://openalex.org/W1986576600', 'https://openalex.org/W1989505230', 'https://openalex.org/W1997014262', 'https://openalex.org/W1998236525', 'https://openalex.org/W2000948557', 'https://openalex.org/W2002195659', 'https://openalex.org/W2004542850', 'https://openalex.org/W2020193594', 'https://openalex.org/W2020251171', 'https://openalex.org/W2023025782', 'https://openalex.org/W2033692463', 'https://openalex.org/W2033757712', 'https://openalex.org/W2036244782', 'https://openalex.org/W2037527898', 'https://openalex.org/W2039486080', 'https://openalex.org/W2048186112', 'https://openalex.org/W2049480922', 'https://openalex.org/W2059905516', 'https://openalex.org/W2061237289', 'https://openalex.org/W2061487678', 'https://openalex.org/W2061541073', 'https://openalex.org/W2064521283', 'https://openalex.org/W2065097700', 'https://openalex.org/W2069460651', 'https://openalex.org/W2092544746', 'https://openalex.org/W2094712966', 'https://openalex.org/W2098286914', 'https://openalex.org/W2098613471', 'https://openalex.org/W2110876580', 'https://openalex.org/W2117235669', 'https://openalex.org/W2123617144', 'https://openalex.org/W2135975456', 'https://openalex.org/W2139570272', 'https://openalex.org/W2142106325', 'https://openalex.org/W2146223790', 'https://openalex.org/W2147295137', 'https://openalex.org/W2152154290', 'https://openalex.org/W2152921443', 'https://openalex.org/W2159367463', 'https://openalex.org/W2161366128', 'https://openalex.org/W2167100261', 'https://openalex.org/W2170671445', 'https://openalex.org/W2175886055', 'https://openalex.org/W2469235726', 'https://openalex.org/W2485563582', 'https://openalex.org/W2951793837'], 'related_works': ['https://openalex.org/W614643624', 'https://openalex.org/W4385273854', 'https://openalex.org/W4382198899', 'https://openalex.org/W251682942', 'https://openalex.org/W2470284246', 'https://openalex.org/W2411030048', 'https://openalex.org/W2367939396', 'https://openalex.org/W2363211455', 'https://openalex.org/W2102688698', 'https://openalex.org/W2019386382'], 'abstract_inverted_index': {'Apical': [0, 202, 518], 'membrane': [1, 203, 519, 529, 563, 1483], 'antigen': [2, 204, 520, 530, 1140, 3190], '1': [3, 205, 521, 2073, 2316, 3263, 3481, 3497, 3624], '(AMA1)': [4, 206, 522], 'of': [5, 17, 68, 77, 93, 121, 128, 134, 160, 200, 207, 219, 270, 279, 295, 323, 330, 336, 362, 402, 412, 420, 436, 457, 496, 516, 579, 664, 667, 686, 690, 900, 914, 1012, 1157, 1226, 1285, 1323, 1364, 1401, 1418, 1425, 1444, 1463, 1473, 1478, 1509, 1520, 1563, 1565, 1574, 1663, 1670, 1808, 1856, 1861, 1863, 1870, 1895, 1907, 1923, 1946, 1956, 2047, 2067, 2146, 2194, 2253, 2276, 2279, 2338, 2367, 2441, 2489, 2528, 2569, 2600, 2640, 2669, 2772, 2854, 2953, 3076, 3146, 3249, 3253, 3341, 3344, 3357, 3416, 3420, 3429, 3447, 3471, 3483, 3496, 3535, 3588, 3620, 3643, 3688, 3707, 3814, 3827, 3839, 3847, 3860, 3874, 3882, 3906, 3970, 3975, 3989, 4019, 4040, 4232, 4315, 4357, 4370, 4406, 4418, 4449], 'the': [6, 15, 66, 91, 114, 122, 140, 208, 217, 268, 293, 316, 324, 342, 413, 449, 453, 493, 497, 513, 665, 684, 687, 691, 694, 822, 896, 1010, 1155, 1229, 1283, 1324, 1329, 1336, 1361, 1405, 1442, 1451, 1458, 1471, 1514, 1518, 1668, 1683, 1713, 1780, 1795, 1803, 1857, 1888, 1893, 1921, 1944, 1954, 2038, 2044, 2068, 2093, 2098, 2108, 2124, 2149, 2154, 2207, 2251, 2274, 2307, 2336, 2342, 2360, 2368, 2374, 2387, 2391, 2408, 2413, 2449, 2461, 2471, 2513, 2517, 2526, 2534, 2538, 2551, 2557, 2566, 2572, 2579, 2601, 2606, 2613, 2662, 2667, 2670, 2682, 2689, 2701, 2762, 2776, 2812, 2821, 2855, 3143, 3242, 3247, 3301, 3339, 3342, 3389, 3432, 3463, 3536, 3540, 3558, 3583, 3644, 3649, 3679, 3686, 3689, 3699, 3725, 3742, 3757, 3782, 3875, 3914, 3918, 4058, 4101, 4229, 4233, 4238, 4246, 4313, 4338, 4367, 4371, 4410, 4415, 4453], 'malaria': [7, 209, 422], 'parasite': [8, 41, 78, 210, 243, 280, 450, 498, 577, 670, 692, 751, 823, 930, 1044, 1310, 1326, 1912, 1936, 2898, 2986, 3102], 'Plasmodium': [9, 211, 447, 568], 'falciparum': [10, 212, 904], 'has': [11, 213, 881, 1429, 1470, 1678, 3924], 'been': [12, 214, 1147, 1430, 1679, 3925, 4243], 'implicated': [13, 215], 'in': [14, 139, 216, 341, 492, 669, 682, 821, 1009, 1046, 1353, 1378, 1506, 1745, 1920, 2077, 2087, 2156, 2268, 2281, 2402, 2456, 2512, 2550, 2576, 2666, 2697, 2826, 2858, 2866, 3027, 3034, 3072, 3193, 3231, 3244, 3246, 3453, 3572, 3574, 3724, 3811, 3865, 3880, 3928, 4237, 4245, 4362, 4423], 'invasion': [16, 218, 578, 671, 1045, 1227, 3147], 'host': [18, 220, 580], 'erythrocytes': [19, 221], 'and': [20, 38, 117, 149, 222, 240, 319, 351, 423, 459, 584, 813, 1036, 1042, 1141, 1272, 1338, 1341, 1376, 1413, 1487, 1528, 1646, 1738, 1801, 1805, 1812, 1883, 1903, 1933, 1952, 1976, 1992, 2008, 2029, 2035, 2049, 2092, 2107, 2123, 2139, 2141, 2159, 2174, 2188, 2223, 2261, 2303, 2318, 2321, 2373, 2407, 2448, 2460, 2482, 2548, 2571, 2597, 2612, 2623, 2634, 2654, 2681, 2700, 2759, 2761, 2796, 2852, 2886, 2946, 2975, 3029, 3047, 3062, 3093, 3142, 3204, 3220, 3300, 3347, 3362, 3382, 3523, 3600, 3608, 3652, 3682, 3717, 3727, 3739, 3857, 3885, 3992, 4030, 4089, 4112, 4192, 4198, 4241, 4281, 4354, 4364, 4408], 'is': [21, 100, 223, 302, 417, 510, 560, 571, 680, 911, 1005, 1028, 1297, 1368, 1422, 1828, 3910], 'an': [22, 57, 224, 259, 561, 818, 1298, 1675, 1818, 1825, 1924, 2380, 2735, 4093], 'important': [23, 58, 225, 260, 575, 1299], 'vaccine': [24, 226, 443, 889], 'candidate.': [25, 227], 'We': [26, 228], 'have': [27, 170, 229, 372, 1146, 3897, 4242], 'previously': [28, 230, 466, 1796, 2873, 2905, 2989, 3927], 'described': [29, 231, 2783, 2874, 2904, 2990], 'a': [30, 49, 75, 81, 88, 97, 135, 175, 198, 232, 251, 277, 283, 290, 299, 337, 377, 400, 887, 912, 1006, 1024, 1316, 1350, 1437, 1447, 1464, 1468, 1476, 1507, 1525, 1561, 1572, 1740, 1746, 1852, 1871, 1916, 1947, 2192, 2225, 2233, 2277, 2439, 2487, 2529, 2638, 2711, 3073, 3250, 3410, 3417, 3438, 3491, 3555, 3586, 3616, 3750, 3824, 3843, 3986, 4005, 4016, 4037, 4050, 4115, 4305, 4447], '20-residue': [31, 233, 1232], 'peptide,': [32, 234, 1233, 1799, 2823], 'R1,': [33, 235, 1800], 'that': [34, 172, 236, 374, 451, 570, 678, 910, 924, 1027, 1038, 1136, 1268, 1313, 1369, 1428, 1868, 2556, 3755, 3850], 'binds': [35, 237], 'to': [36, 47, 74, 90, 103, 112, 174, 188, 195, 238, 249, 276, 292, 305, 314, 376, 390, 397, 405, 465, 483, 566, 573, 693, 816, 1034, 1040, 1308, 1360, 1382, 1403, 1408, 1432, 1681, 1782, 1877, 1929, 1931, 1943, 2097, 2232, 2287, 2306, 2383, 2412, 2516, 2533, 2564, 2661, 2829, 2984, 3036, 3055, 3241, 3337, 3431, 3450, 3502, 3557, 3595, 3603, 3720, 3736, 3749, 3823, 3834, 3977, 4092, 4100, 4283, 4337, 4341, 4445], 'AMA1': [37, 53, 118, 146, 239, 255, 320, 348, 668, 746, 826, 880, 906, 920, 1041, 1320, 1880, 1901, 1908, 1932, 3352, 3392, 3430, 3448, 3509, 3614, 3650], 'subsequently': [39, 241], 'blocks': [40, 242], 'invasion.': [42, 244], 'Because': [43, 245, 917], 'this': [44, 69, 108, 246, 271, 310, 431, 485, 508, 1003, 1139, 1788, 1939, 2116, 2205, 2469, 2496, 2577, 3907, 3923], 'peptide': [45, 70, 95, 124, 142, 178, 193, 247, 272, 297, 326, 344, 380, 395, 1151, 1224, 1296, 1331, 1407, 1426, 1448, 1459, 1469, 1741, 1884, 1890, 2388, 2603, 2673, 2684, 2693, 2778, 2974, 3155, 3166, 3234, 3589, 3645, 3915], 'appears': [46, 248, 815], 'target': [48, 250, 1023], 'site': [50, 252, 1317], 'critical': [51, 253, 1318], 'for': [52, 61, 83, 254, 263, 285, 504, 512, 576, 1030, 1282, 1302, 1319, 1823, 1950, 2112, 2128, 2168, 2201, 2250, 2300, 2315, 2335, 2427, 2465, 2525, 2646, 2981, 3066, 3101, 3262, 3547, 3598, 3606, 3623, 3636, 3786, 3805, 4109, 4228, 4352], 'function,': [54, 256], 'it': [55, 257, 679, 814, 1314, 1504], 'represents': [56, 258, 1915], 'lead': [59, 190, 261, 392, 1300, 1438], 'compound': [60, 262, 1301, 1927], 'anti-malarial': [62, 264, 505, 1926], 'drug': [63, 265, 892, 1019, 1303], 'development.': [64, 266], 'However,': [65, 267, 1322], 'effectiveness': [67, 269], 'inhibitor': [71, 273, 1225], 'was': [72, 274, 1228, 1332, 1399, 1875, 2018, 2075, 2085, 2095, 2105, 2110, 2121, 2126, 2134, 2151, 2160, 2170, 2180, 2209, 2230, 2264, 2289, 2298, 2313, 2332, 2362, 2371, 2377, 2382, 2400, 2410, 2425, 2433, 2463, 2473, 2506, 2522, 2545, 2591, 2610, 2615, 2631, 2651, 2659, 2675, 2685, 2694, 2703, 2765, 2779, 2864, 2900, 3032, 3135, 3148, 3191, 3214, 3272, 3284, 3295, 3303, 3335, 3393, 3407, 3435, 3475, 3488, 3542, 3551, 3628, 3657, 3711, 3734, 3779, 3832, 4055, 4420], 'limited': [73, 275], 'subset': [76, 278], 'isolates,': [79, 281], 'indicating': [80, 282, 3849], 'requirement': [82, 284], 'broader': [84, 286], 'strain': [85, 287], 'specificity.': [86, 288], 'Furthermore,': [87, 289, 1938], 'barrier': [89, 291, 1359], 'utility': [92, 294, 1348], 'any': [94, 296, 3221, 3851], 'as': [96, 298, 825, 886, 1274, 1290, 1349, 1366, 2040, 2782, 2872, 2903, 2988, 3388, 3513, 3544, 4160, 4286], 'potential': [98, 300, 888, 1412, 1512, 1781], 'therapeutic': [99, 301, 1351], 'its': [101, 303, 1306, 1347, 1354, 1410], 'susceptibility': [102, 304], 'rapid': [104, 306], 'proteolytic': [105, 115, 150, 307, 317, 352, 1488, 1743], 'degradation.': [106, 308], 'In': [107, 157, 309, 359, 740, 1032, 1787, 3529], 'study,': [109, 311, 1789], 'we': [110, 169, 312, 371, 1790, 1832], 'sought': [111, 313], 'improve': [113, 315, 1409, 1879], 'stability': [116, 151, 318, 353, 1489, 1885], 'binding': [119, 321, 685, 1526, 1531, 3363, 3568, 3584, 3753], 'properties': [120, 322, 1532, 1807], 'R1': [123, 141, 162, 325, 343, 364, 1234, 1295, 1330, 1406, 1814, 1858, 1865, 2777, 2822, 2973, 2977, 3233, 3237, 3254, 3345], 'by': [125, 327, 430, 1374, 1667, 2043, 2153, 2266, 2273, 2436, 2687, 2767, 2835, 2850, 2950, 3099, 3216, 3274, 3490, 3553, 3631, 3697, 3746, 3808, 4162], 'systematic': [126, 328, 3722], 'methylation': [127, 329, 1417], 'backbone': [129, 143, 331, 345, 1419], 'amides': [130, 332, 1420], '(N-methylation).': [131, 333], 'The': [132, 334, 661, 1221, 1294, 1416, 1461, 1998, 2132, 2144, 2256, 2430, 2520, 2541, 2626, 2649, 2672, 2692, 2705, 2896, 3189, 3403, 3485, 3704, 3777, 3830, 3902, 4457], 'inclusion': [133, 335, 1669, 1869], 'single': [136, 338, 1872, 3844], 'N-methyl': [137, 339, 1453, 1566, 1671, 1819, 1826, 1854, 1873, 1897, 1999, 2041, 2381, 2535, 2573, 3919], 'group': [138, 340, 1466, 1820, 1874, 2536, 2609, 3920], 'dramatically': [144, 180, 346, 382, 1878], 'increased': [145, 347, 1900], 'affinity,': [147, 349, 1881], 'bioactivity,': [148, 350, 1882], 'without': [152, 354, 1886], 'introducing': [153, 355], 'global': [154, 356, 1889], 'structural': [155, 357, 898], 'alterations.': [156, 358], 'addition,': [158, 360], 'N-methylation': [159, 361, 1835], 'multiple': [161, 363, 1784, 1896], 'residues': [163, 365, 1445, 1793, 1822, 2042], 'further': [164, 366, 1358, 1899, 3655], 'improved': [165, 367, 1905], 'these': [166, 368, 1809, 1864, 3888, 3893], 'properties.': [167, 369, 1415], 'Therefore,': [168, 370], 'shown': [171, 373, 1680, 3864], 'modifications': [173, 375], 'biologically': [176, 378, 1664], 'active': [177, 379, 1665], 'can': [179, 381, 1279], 'enhance': [181, 383, 1682], 'activity.': [182, 384], 'This': [183, 385, 1440, 1776, 1914, 2296, 2309, 2422, 3550], 'approach': [184, 386, 1777, 3441], 'could': [185, 387, 2560, 4309], 'be': [186, 388, 574, 817, 1280, 2384, 2562, 4310], 'applied': [187, 389, 3240], 'many': [189, 391], 'peptides': [191, 393, 1135, 1365, 1570, 1666, 2707, 3024, 3346, 3810, 3841, 3889, 3931, 4234], 'or': [192, 394, 891, 1018, 1277, 1289, 1344, 3235, 4099, 4346, 4397], 'therapeutics': [194, 396, 1291], 'simultaneously': [196, 398], 'optimize': [197, 399, 1783], 'number': [199, 401, 1477, 1562], 'parameters.': [201, 403], 'According': [404], 'World': [406], 'Health': [407], 'Organization': [408], 'reports,': [409], 'almost': [410], 'half': [411], 'world': [414], 'human': [415], 'population': [416], 'at': [418, 1513, 1524, 3069, 3137, 3209, 3265, 3305, 3367, 3413, 3466, 3532, 3578, 3615, 3685, 3921, 4001, 4025, 4046, 4083, 4096, 4278], 'risk': [419], 'contracting': [421], 'approximately': [424], 'one': [425, 1423, 3534], 'million': [426], 'people': [427], 'are': [428, 438, 461, 487, 672, 829, 925, 1371, 1560, 3863, 4235], 'killed': [429], 'disease': [432, 486], 'each': [433, 1862, 3056, 3530], 'year,': [434], 'most': [435, 454, 1222, 3840, 3903], 'which': [437, 1824, 2288, 2664, 2817, 3640], 'young': [439], 'children.': [440], 'No': [441, 4343], 'reliable': [442], 'currently': [444], 'exists': [445], 'against': [446, 928, 1335], 'falciparum,': [448], 'causes': [452], 'severe': [455], 'form': [456, 689], 'malaria,': [458], 'parasites': [460, 2947, 2958, 3050, 3088], 'becoming': [462], 'increasingly': [463], 'resistant': [464], 'effective': [467, 927, 1334, 1925], 'pharmaceuticals': [468, 1367], '(1Ridley': [469], 'R.G.': [470], 'Nature.': [471], '2002;': [472, 994, 1208, 1768, 3126, 4385], '415:': [473], '686-693Crossref': [474], 'PubMed': [475, 632, 656, 715, 735, 771, 808, 851, 875, 953, 969, 997, 1059, 1085, 1130, 1186, 1216, 1262, 1393, 1554, 1591, 1707, 1733, 1771, 2245, 2354, 2928, 2941, 2968, 3018, 3129, 3330, 3772, 3945, 3962, 4074, 4155, 4178, 4220, 4262, 4328, 4388, 4440], 'Scopus': [476, 633, 657, 716, 736, 772, 809, 852, 876, 954, 970, 998, 1060, 1086, 1131, 1187, 1217, 1263, 1394, 1555, 1592, 1623, 1642, 1657, 1708, 1734, 1772, 1847, 2062, 2246, 2355, 2929, 2942, 2969, 3019, 3130, 3331, 3773, 3946, 3963, 4075, 4156, 4179, 4221, 4263, 4329, 4389, 4441], '(707)': [477], 'Google': [478, 635, 659, 718, 738, 774, 811, 854, 878, 956, 972, 1000, 1062, 1088, 1133, 1189, 1219, 1265, 1396, 1557, 1594, 1625, 1644, 1659, 1710, 1736, 1774, 1849, 2064, 2248, 2357, 2589, 2931, 2944, 2971, 3021, 3132, 3333, 3775, 3948, 3965, 4077, 4158, 4181, 4223, 4265, 4331, 4391, 4443], 'Scholar).': [479, 660, 739, 879, 1220, 1266, 1397, 1502, 1558, 1660, 1775, 2065, 2358, 2805, 2895, 2972, 3022, 3133, 3776, 3966, 4078, 4182, 4224, 4266, 4392], 'Thus,': [480], 'novel': [481], 'strategies': [482], 'combat': [484], 'urgently': [488], 'required.': [489, 3658], 'Proteins': [490], 'involved': [491, 681, 2498], 'erythrocytic': [494], 'stage': [495, 509, 2957], 'life': [499], 'cycle': [500], 'represent': [501], 'attractive': [502], 'targets': [503, 1315], 'therapeutics,': [506], 'because': [507, 1305], 'responsible': [511], 'clinical': [514], 'symptoms': [515], 'malaria.': [517], '3The': [523], 'abbreviations': [524], 'used': [525, 1833, 2563, 3336, 3543, 3735, 4421], 'are:': [526], 'AMA1,': [527], 'apical': [528], '1;': [531], 'MTBD,': [532, 1985], '7-methyl-1,5,7-triazabicyclo-[4.4.0]-dec-5-ene;': [533], 'Fmoc,': [534], 'N-(9-fluorenyl)methoxycarbonyl;': [535], 'PBS,': [536, 3028, 3087, 3219], 'phosphate-buffered': [537, 2859], 'saline;': [538], 'NOE,': [539], 'nuclear': [540, 4010, 4032], 'Overhauser': [541, 4011, 4033], 'effect;': [542], 'mAb,': [543], 'monoclonal': [544], 'antibody;': [545], 'HBTU,': [546], '2-(1H-benzotriazol-1-yl)-1,1,3,3,-tetramethyluronium': [547], 'hexafluorophosphate;': [548], 'DMF,': [549, 1972], 'dimethylformamide;': [550], 'DCM,': [551, 1973], 'dichloromethane;': [552], 'TNBS,': [553], '2,4,6-trinitrobenzenesulfonic': [554], 'acid;': [555], 'SPR,': [556], 'surface': [557, 1156, 3406, 3434, 3465, 3556, 3651], 'plasmon': [558], 'resonance.': [559, 4103], 'integral': [562], 'protein': [564, 820, 3213, 3564], 'common': [565], 'all': [567, 1966, 2954, 3642, 3708, 3714], 'species': [569], 'thought': [572], 'red': [581, 3160, 3171], 'blood': [582, 3161, 3172], 'cells': [583, 2810, 3162, 3173, 3538], 'hepatocytes': [585], '(2Silvie': [586], 'O.': [587], 'Franetich': [588], 'J.F.': [589, 865], 'Charrin': [590], 'S.': [591, 758, 1065, 1758, 4167, 4319], 'Mueller': [592], 'M.S.': [593], 'Siau': [594], 'A.': [595, 947, 985, 1069, 1174, 1194, 1198, 1250, 1696, 1754, 3006, 3117], 'Bodescot': [596], 'M.': [597, 760, 1180, 1204, 1256, 1579, 1750, 2790, 2792, 2880, 2882, 3012, 3316, 3933, 4063, 4209], 'Rubinstein': [598], 'E.': [599, 867, 1534, 1688, 1692, 3951], 'Hannoun': [600], 'L.': [601, 1200], 'Charoenvit': [602], 'Y.': [603, 1581, 1600, 1604], 'Kocken': [604], 'C.H.': [605, 1091], 'Thomas': [606, 722, 1076, 1117, 1197], 'A.W.': [607, 723, 941, 991, 1077, 1118, 3123], 'van': [608, 1092, 1100, 1104, 1107], 'Gemert': [609, 1105], 'G.J.': [610, 1106, 4169], 'Sauerwein': [611], 'R.W.': [612], 'Blackman': [613], 'M.J.': [614], 'Anders': [615, 645, 704, 798, 840, 942, 962, 1052, 1177, 1201, 1253, 3009], 'R.F.': [616, 646, 705, 754, 799, 841, 943, 963, 1053, 1178, 1202, 1254, 3010], 'Pluschke': [617], 'G.': [618, 725, 1493, 1694, 4433], 'Mazier': [619], 'D.': [620, 766, 779, 1760], 'J.': [621, 640, 699, 801, 835, 933, 977, 1119, 1205, 1536, 1543, 1636, 1701, 1727, 1840, 2055, 2911, 2963, 3109, 3938, 3956, 4068, 4128, 4149, 4172, 4214, 4256, 4322, 4382, 4434], 'Biol.': [622, 1120, 1206, 1544, 1767, 4384], 'Chem.': [623, 1121, 1207, 1498, 1545, 1585, 1638, 1703, 1729, 1842, 2057, 3940], '2004;': [624, 732, 950, 3959], '279:': [625], '9490-9496Abstract': [626], 'Full': [627, 629, 1125, 1127, 1211, 1213, 1549, 1551, 2925], 'Text': [628, 630, 1126, 1128, 1212, 1214, 1550, 1552, 2926], 'PDF': [631, 1129, 1215, 1553, 2927], '(256)': [634, 658, 717, 853], 'Scholar,': [636, 719, 775, 855, 957, 973, 1063, 1089, 1190, 2932, 3949, 4134], '3Triglia': [637], 'T.': [638, 697, 833, 2583, 4377], 'Healer': [639, 698, 834], 'Caruana': [641, 700, 836], 'S.R.': [642, 701, 837], 'Hodder': [643, 702, 838, 936], 'A.N.': [644, 703, 839, 937, 959, 1049], 'Crabb': [647, 706, 842], 'B.S.': [648, 707, 843], 'Cowman': [649, 708, 844, 944], 'A.F.': [650, 709, 845, 945], 'Mol.': [651, 710, 846, 948, 4383], 'Microbiol.': [652, 711, 847, 949], '2000;': [653, 712, 848, 872, 4175], '38:': [654, 713, 849], '706-718Crossref': [655, 714, 850], 'molecular': [662, 2763], 'mechanisms': [663], 'role': [666, 1519], 'unknown,': [673], 'but': [674, 2955], 'recent': [675], 'evidence': [676], 'suggests': [677], 'stabilizing': [683], 'invasive': [688], 'erythrocyte': [695], '(3Triglia': [696, 832], '4Mitchell': [720], 'G.H.': [721], 'Margos': [724], 'Dluzewski': [726, 1193], 'A.R.': [727], 'Bannister': [728, 1111], 'L.H.': [729, 989, 1112, 3121], 'Infect.': [730, 870, 964, 992, 1054, 1080, 1181, 1257, 3013, 3124], 'Immun.': [731, 871, 965, 993, 1055, 1081, 1182, 1258, 3014, 3125], '72:': [733], '154-158Crossref': [734], '(182)': [737], 'animal': [741], 'models,': [742], 'immunization': [743, 918], 'with': [744, 919, 1450, 1571, 2137, 2182, 2191, 2211, 2323, 2416, 2438, 2476, 2486, 2617, 2637, 2837, 3085, 3184, 3218, 3226, 3268, 3276, 3286, 3351, 3409, 3562, 3871, 3985, 4015, 4036, 4461], 'recombinant': [745, 3187], 'induces': [747, 921], 'protection': [748], 'from': [749, 1149, 1910, 1968, 1980, 1996, 2012, 2020, 2033, 2595, 3354, 3593, 3601, 3648, 3670, 3713, 3741, 3781, 3899, 4272, 4414], 'subsequent': [750], 'challenge': [752], '(5Anders': [753], 'Crewther': [755, 780, 960, 1050], 'P.E.': [756, 781, 961, 1051], 'Edwards': [757, 790], 'Margetts': [759], 'Matthew': [761], 'M.L.': [762], 'Pollock': [763], 'B.': [764, 1690, 1756, 3955], 'Pye': [765, 778], 'Vaccine.': [767], '1998;': [768, 1122, 3769], '16:': [769, 4176], '240-247Crossref': [770], '(188)': [773], '6Collins': [776], 'W.E.': [777], 'Vandenberg': [782], 'K.L.': [783], 'Galland': [784], 'G.G.': [785], 'Sulzer': [786], 'A.J.': [787, 4136], 'Kemp': [788], 'D.J.': [789], 'S.J.': [791, 1720, 4125], 'Coppel': [792, 2912], 'R.L.': [793, 2913], 'Sullivan': [794], 'J.S.': [795], 'Morris': [796, 4141], 'C.L.': [797, 1602], 'Am.': [800, 1841, 2056, 3939], 'Trop.': [802, 2919], 'Med.': [803, 1497, 1702, 1728, 1766, 2920], 'Hyg.': [804, 2921], '1994;': [805], '51:': [806], '711-719Crossref': [807], '(165)': [810], 'Scholar),': [812, 1001, 1134, 1595, 1626, 1645, 1711, 1737, 1850, 2945, 4332], 'essential': [819], 'life-cycle': [824], 'genetic': [827], 'knockouts': [828], 'not': [830, 1342, 1829, 2561], 'viable': [831], '7Hehl': [856], 'A.B.': [857], 'Lekutis': [858], 'C.': [859, 1114, 1540, 1618, 2909, 2960, 4205], 'Grigg': [860], 'M.E.': [861], 'Bradley': [862], 'P.J.': [863], 'Dubremetz': [864], 'Ortega-Barria': [866], 'Boothroyd': [868], 'J.C.': [869, 1616], '68:': [873], '7078-7086Crossref': [874], '(137)': [877], 'therefore': [882, 1021, 1400, 1778], 'received': [883], 'much': [884], 'attention': [885], 'candidate': [890], 'target.': [893], 'Although': [894], 'lacking': [895], 'major': [897, 3845, 3976, 4230], 'diversity': [899, 1004], 'some': [901], 'other': [902, 3929], 'P.': [903, 1764, 3322, 3358, 4211, 4379], 'antigens,': [905], 'exhibits': [907], 'allelic': [908], 'variation': [909], 'result': [913], 'point': [915], 'mutations.': [916], 'inhibitory': [922, 1144], 'antibodies': [923, 3290], 'less': [926], 'heterologous': [929], 'lines': [931, 1327], '(8Healer': [932], 'Murphy': [934, 1721], 'V.': [935, 4065, 4067], 'Masciantonio': [938, 1165, 1241, 2997], 'R.': [939, 1166, 1242, 2917, 2998], 'Gemmill': [940], 'Batchelor': [946], '52:': [951], '159-168Crossref': [952], '(140)': [955], '9Hodder': [958], '2001;': [966, 1056, 1730], '69:': [967, 1057], '3286-3294Crossref': [968, 1058], '(275)': [971, 1061], '10Kennedy': [974], 'M.C.': [975, 3107], 'Wang': [976, 3108], 'Zhang': [978, 3110], 'Y.L.': [979, 3111], 'Miles': [980, 3112], 'A.P.': [981, 1116, 3113], 'Chitsaz': [982, 3114], 'F.': [983, 1192, 3115, 3935], 'Saul': [984, 3116], 'Long': [986, 3118], 'C.A.': [987, 3119], 'Miller': [988, 2048, 3120], 'Stowers': [990, 3122], '70:': [995, 3127], '6948-6960Crossref': [996, 3128], '(221)': [999, 3131], 'overcoming': [1002], 'key': [1007], 'hurdle': [1008], 'development': [1011, 1945], 'AMA1-based': [1013], 'anti-malarials.': [1014], 'An': [1015], 'immune': [1016], 'response': [1017, 3706], 'would': [1020], 'ideally': [1022], 'conserved': [1025], 'region': [1026], 'required': [1029, 2602], 'function.': [1031, 1321], 'addition': [1033, 2275], 'polyclonal': [1035], 'mAbs': [1037], 'bind': [1039, 1930], 'block': [1043, 1309], 'vitro': [1047], '(9Hodder': [1048], '11Dutta': [1064], 'Haynes': [1066], 'J.D.': [1067, 1073], 'Barbosa': [1068], 'Ware': [1070], 'L.A.': [1071], 'Snavely': [1072], 'Moch': [1074], 'J.K.': [1075, 1168, 1244, 3000], 'Lanar': [1078], 'D.E.': [1079], '2005;': [1082, 1183, 1259, 1546, 3015], '73:': [1083, 1184, 1260, 3016], '2116-2122Crossref': [1084], '(55)': [1087, 1735], '12Kocken': [1090], 'der': [1093, 1108], 'Wel': [1094], 'A.M.': [1095, 1164, 1196, 1240, 2788, 2878, 2996], 'Dubbeld': [1096], 'M.A.': [1097, 1686], 'Narum': [1098], 'D.L.': [1099, 1612], 'de': [1101], 'Rijke': [1102], 'F.M.': [1103, 4321], 'Linde': [1109], 'X.': [1110], 'Janse': [1113], 'Waters': [1115], '273:': [1123], '15119-15124Abstract': [1124], '(143)': [1132], 'specifically': [1137], 'recognize': [1138, 1269], 'demonstrate': [1142], 'similar': [1143], 'activity': [1145, 1955, 3105], 'isolated': [1148, 2686], 'random': [1150], 'libraries': [1152], 'displayed': [1153], 'on': [1154, 1436, 2537, 2710, 2734, 3395, 3539, 3678, 4004, 4049, 4312], 'phage': [1158, 2814, 2856, 3255, 3271, 3283], '(13Harris': [1159, 1235, 2991], 'K.S.': [1160, 1236, 2992], 'Casey': [1161, 1237, 2993], 'J.L.': [1162, 1238, 2786, 2876, 2994, 4255], 'Coley': [1163, 1195, 1239, 2787, 2877, 2995], 'Sabo': [1167, 1243, 2999], 'Keizer': [1169, 1245, 3001], 'D.W.': [1170, 1246, 3002], 'Lee': [1171, 1247, 3003, 3936], 'E.F.': [1172, 1248, 3004], 'McMahon': [1173, 1249, 3005], 'Norton': [1175, 1251, 3007, 4170], 'R.S.': [1176, 1252, 3008, 4171], 'Foley': [1179, 1203, 1255, 2789, 2879, 3011], '6981-6989Crossref': [1185, 1261, 3017], '(88)': [1188, 1264, 3020], '14Li': [1191], 'Tilley': [1199], '277:': [1209], '50303-50310Abstract': [1210], '(44)': [1218, 3332], 'potent': [1223], 'recently': [1230], 'identified': [1231, 1797], 'Peptides': [1267], 'functional': [1270], 'sites': [1271], 'act': [1273], 'biological': [1275, 1379, 1747], 'agonists': [1276], 'antagonists': [1278], 'useful': [1281, 1480], 'design': [1284, 1922], 'small': [1286, 2226, 3443], 'molecule': [1287], 'mimics,': [1288], 'per': [1292, 2869], 'se.': [1293], 'development,': [1304], 'ability': [1307, 2983], 'growth': [1311, 2987], 'indicates': [1312], 'four': [1325], 'tested,': [1328], 'only': [1333], '3D7': [1337, 2897, 3515, 3599], 'D10': [1339], 'strains,': [1340], 'HB3': [1343, 3518], 'W2mef,': [1345], 'limiting': [1346], 'agent': [1352], 'current': [1355], 'form.': [1356], 'A': [1357, 2329, 3308], 'general': [1362], 'use': [1363], 'they': [1370], 'rapidly': [1372, 3787], 'degraded': [1373], 'peptidases': [1375], 'proteases': [1377], 'fluids,': [1380], 'leading': [1381], 'poor': [1383], 'bioavailability': [1384], '(15Egleton': [1385], 'R.D.': [1386], 'Davis': [1387], 'T.P.': [1388], 'Peptides.': [1389], '1997;': [1390, 1639, 1844, 2059, 2922], '18:': [1391], '1431-1439Crossref': [1392], '(157)': [1395], 'It': [1398], 'interest': [1402], 'modify': [1404], 'pharmaceutical': [1411], 'AMA1-binding': [1414, 1798], '(N-methylation)': [1421], 'strategy': [1424, 1949], 'modification': [1427, 1662], 'employed': [1431], 'confer': [1433], 'superior': [1434], 'characteristics': [1435], 'peptide.': [1439, 1859, 2671], 'involves': [1441], 'replacement': [1443], 'within': [1446, 1794, 3800], 'sequence': [1449, 1677, 2039, 2389, 4061, 4123], 'corresponding': [1452], 'amino': [1454, 1567, 1672, 2000, 2543, 2574, 2608], 'acid,': [1455], 'subtly': [1456], 'changing': [1457], 'backbone.': [1460], 'introduction': [1462, 1894], 'methyl': [1465, 1987, 2442], 'into': [1467, 1674, 1821, 2037, 2386], 'advantage': [1472], 'substantially': [1474], 'improving': [1475], 'pharmacokinetically': [1479], 'parameters,': [1481], 'including': [1482, 1576], 'permeability,': [1484], 'conformational': [1485, 3908], 'flexibility,': [1486], '(16Fairlie': [1490], 'D.P.': [1491], 'Abbenante': [1492], 'March': [1494], 'D.R.': [1495], 'Curr.': [1496], '1995;': [1499, 2586, 4152, 4217], '2:': [1500, 4072, 4326], '654-686Google': [1501], 'Additionally,': [1503], 'results': [1505], 'loss': [1508], 'hydrogen': [1510, 1522, 4347], 'bonding': [1511], 'affected': [1515], 'site,': [1516], 'reducing': [1517], 'mainchain': [1521], 'bonds': [1523], 'interface': [1527], 'potentially': [1529], 'altering': [1530, 1887], '(17Bergseng': [1533], 'Xia': [1535, 4206], 'Kim': [1537], 'C.Y.': [1538, 3937], 'Khosla': [1539], 'Sollid': [1541], 'L.M.': [1542], '280:': [1547], '21791-21796Abstract': [1548], '(32)': [1556], 'There': [1559], 'examples': [1564], 'acid': [1568, 2258, 2370, 2544], 'containing': [1569, 3818], 'range': [1573, 4339], 'bioactivities,': [1575], 'antibiotic': [1577], '(18Ebata': [1578], 'Takahashi': [1580], 'Otsuka': [1582], 'H.': [1583, 1606, 1700, 3320], 'Bull.': [1584], 'Soc.': [1586, 1843, 2058, 2918, 3941], 'Jpn.': [1587], '1966;': [1588], '39:': [1589], '2535-2538Crossref': [1590], '(29)': [1593], 'anti-viral': [1596], '(19Pettit': [1597], 'G.R.': [1598], 'Kamano': [1599], 'Herald': [1601], 'Fujii': [1603], 'Kizu': [1605], 'Boyd': [1607], 'M.R.': [1608], 'Boettner': [1609], 'F.E.': [1610], 'Doubek': [1611], 'Schmidt': [1613], 'J.M.': [1614, 1629], 'Chapuis': [1615], 'Michel': [1617], 'Tetrahedron.': [1619], '1993;': [1620], '49:': [1621], '9151-9170Crossref': [1622], '(168)': [1624, 2930], 'anti-cancer': [1627], '(20Ramanjulu': [1628], 'Ding': [1630], 'X.B.': [1631], 'Joullie': [1632], 'M.M.': [1633], 'Li': [1634], 'W.R.': [1635], 'Org.': [1637], '62:': [1640], '4961-4969Crossref': [1641], '(24)': [1643], 'immunosuppressant': [1647], 'activities': [1648], '(21Wenger': [1649], 'R.M.': [1650], 'Helv.': [1651], 'Chim.': [1652], 'Acta.': [1653], '1984;': [1654], '67:': [1655], '502-525Crossref': [1656], '(161)': [1658], 'Importantly,': [1661], 'acids': [1673, 2001], 'original': [1676], 'potency': [1684], '(22Dechantsreiter': [1685], 'Planker': [1687], 'Matha': [1689], 'Lohof': [1691], 'Holzemann': [1693], 'Jonczyk': [1695], 'Goodman': [1697], 'S.L.': [1698, 2907], 'Kessler': [1699], '1999;': [1704], '42:': [1705], '3033-3040Crossref': [1706], '(753)': [1709], 'change': [1712], 'receptor': [1714], 'subtype': [1715], 'selectivity': [1716], '(23Rajeswaran': [1717], 'W.G.': [1718], 'Hocart': [1719], 'W.A.': [1722], 'Taylor': [1723], 'J.E.': [1724, 2239, 2348], 'Coy': [1725], 'D.H.': [1726], '44:': [1731], '1305-1311Crossref': [1732], 'stabilize': [1739], 'toward': [1742], 'degradation': [1744], 'system': [1748], '(24Bruehlmeier': [1749], 'Garayoa': [1751], 'E.G.': [1752], 'Blanc': [1753], 'Holzer': [1755], 'Gergely': [1757], 'Tourwe': [1759], 'Schubiger': [1761], 'P.A.': [1762], 'Blauenstein': [1763], 'Nucl.': [1765], '29:': [1769], '321-327Crossref': [1770], '(63)': [1773], 'offers': [1779], 'parameters': [1785], 'simultaneously.': [1786], 'systematically': [1791], 'N-methylate': [1792], 'describe': [1802], 'synthesis': [1804, 2169, 2604], 'altered': [1806], 'mono-,': [1810], 'di-,': [1811], 'tri-N-methylated': [1813], 'derivatives.': [1815], 'To': [1816, 3581], 'introduce': [1817], 'analogue': [1827], 'commercially': [1830], 'available,': [1831], 'on-resin': [1834], '(25Miller': [1836, 2051], 'S.C.': [1837, 2052], 'Scanlan': [1838, 2050, 2053], 'T.S.': [1839, 2054], '119:': [1845, 2060], '2301-2302Crossref': [1846, 2061], '(216)': [1848, 2063], 'facilitating': [1851], 'comprehensive': [1853], 'scan': [1855], 'Analysis': [1860], 'derivatives': [1866, 3350], 'revealed': [1867], 'sufficient': [1876], 'structure.': [1891], 'Moreover,': [1892], 'groups': [1898], 'affinity': [1902, 3790, 3797], 'slightly': [1904], 'recognition': [1906], 'derived': [1909, 3794], 'different': [1911, 3355, 3968], 'lines.': [1913], 'substantial': [1917], 'step': [1918], 'forward': [1919], 'able': [1928], 'inhibit': [1934, 2985], 'malarial': [1935], 'growth.': [1937], 'work': [1940], 'may': [1941], 'contribute': [1942], 'rational': [1948], 'modulating': [1951], 'optimizing': [1953], 'bioactive': [1957], 'peptides.': [1958], 'Materials-Chlorotrityl': [1959], 'resin,': [1960], 'N,N-diisopropylethylamine,': [1961], 'piperidine,': [1962], 'hydroxybenzotriazole,': [1963], 'HBTU': [1964, 2280], 'were': [1965, 1978, 1994, 2010, 2031, 2708, 2732, 2757, 2824, 2833, 2948, 2979, 3025, 3053, 3064, 3089, 3097, 3182, 3206, 3224, 3239, 3365, 3460, 3512, 3570, 3610, 3662, 3675, 3695, 3793, 3803, 3853, 3878, 3890, 3999, 4022, 4043, 4081, 4090, 4107, 4184, 4270, 4335, 4350, 4360, 4401], 'obtained': [1967, 1979, 1995, 2011, 2019, 2032], 'GLBiochem,': [1969], 'Shanghai,': [1970], 'China.': [1971], 'diethyl': [1974], 'ether,': [1975], '2-mercaptoethanol': [1977], 'Ajax': [1981], 'Chemicals': [1982], '(Melbourne,': [1983, 2015], 'Australia).': [1984, 2016, 3673], '1,8-diazabicyclo[5.4.0]undec-7-ene,': [1986], 'triflate,': [1988], 'o-nitrobenzenesulfonyl': [1989, 2394, 2518], 'chloride,': [1990], 'chloranil,': [1991], 'TNBS': [1993, 2234, 2343, 2558], 'Sigma-Aldrich.': [1997], 'Fmoc-NMe-Val-OH,': [2002], 'Fmoc-NMe-Phe-OH,': [2003], 'Fmoc-NMe-Ala-OH,': [2004], 'Fmoc-NMe-Leu-OH,': [2005], 'Fmoc-NMe-Ile-OH,': [2006], 'Fmoc-NMe-Met-OH,': [2007], 'Fmoc-Ser-OH': [2009], 'Peptide': [2013, 2593, 3626], 'Solutions': [2014], 'Fmoc-NMe-Arg(Mtr)-OH': [2017], 'Chem': [2021], 'Impex': [2022], '(Wood': [2023], 'Dale,': [2024], 'IL).': [2025], 'Fmoc-Lys(Boc)-OH,': [2026], 'Fmoc-His(Trt)-OH,': [2027], 'Fmoc-Ser(tBu)-OH,': [2028], 'Fmoc-Glu(OtBu)-OH': [2030], 'GLBiochem': [2034], 'incorporated': [2036, 2385], '"on-resin"': [2045], 'method': [2046], 'Derivatization': [2066], 'Resin-Chlorotrityl': [2069], 'resin': [2070, 2133, 2150, 2157, 2208, 2330, 2414, 2472, 2521, 2614, 2627], '(1.0': [2071], 'g,': [2072], 'mmol)': [2074, 2084], 'suspended': [2076], 'dry': [2078, 2088, 2403], 'DCM': [2079, 2089, 2138, 2212, 2404, 2618], '(10': [2080, 2090, 3373, 3494], 'ml).': [2081, 2328, 2494], 'Fmoc-Lys(Boc)-OH': [2082], '(1': [2083, 2119, 2259, 3477], 'dissolved': [2086, 2401, 2696], 'ml),': [2091, 2216, 2222, 2406, 2459, 2481], 'solution': [2094, 2109, 2125, 2193, 2278, 2297, 2409, 2440, 2488, 2514, 2639, 2702], 'added': [2096, 2290, 2305, 2411, 2660, 3033, 3054], 'resin.': [2099, 2308], 'N,N-diisopropylethylamine': [2100, 2291], '(4': [2101, 2184, 2213, 2219, 2325, 2405, 2458, 2478], 'mmol,': [2102, 2397, 2419, 2445], '680': [2103], 'μl)': [2104, 3046, 3052, 3446], 'added,': [2106, 2122], 'stirred': [2111, 2127, 2426, 2464], '2': [2113, 2294, 2301, 2428, 2647, 3185], 'h.': [2114, 2429, 2648], 'After': [2115, 2204, 2468, 3083], 'time': [2117, 2206, 3641, 3988, 4018, 4039], 'methanol': [2118], 'ml)': [2120, 2187, 2271, 2622, 2645, 2658], 'another': [2129, 2365], '30': [2130, 2466, 2501], 'min.': [2131, 2203, 2467, 3625], 'washed': [2135, 2181, 2210, 2322, 2475, 2616], 'sequentially': [2136], 'ether': [2140, 2656], 'then': [2142, 2189, 2217, 2224, 2304, 2319, 2333, 2364, 2434, 2483, 2523, 2546, 2635, 2652, 2695, 3091, 3629, 3683], 'air-dried.': [2143], 'loading': [2145], 'Fmoc-Lys(Boc)': [2147], 'onto': [2148], 'estimated': [2152], 'increase': [2155], 'weight': [2158, 2764], 'typically': [2161, 2171, 3591], '0.5–0.6': [2162], 'mmol/g.': [2163], 'Solid-phase': [2164], 'Synthesis': [2165], 'Protocol-The': [2166], 'scale': [2167], '0.5': [2172, 2285], 'g': [2173], '0.25': [2175], 'mmol.': [2176], 'Resin': [2177, 2596], '(0.5': [2178], 'g)': [2179, 2630], 'DMF': [2183, 2218, 2269, 2282, 2324, 2457, 2477], '×': [2185, 2214, 2220, 2326, 2479, 2500, 2620, 2724, 2749, 3175, 3257], '10': [2186, 2202, 2215, 2221, 2327, 2480, 2621, 2644, 3414, 3454, 3819], 'treated': [2190, 2484, 2636], '25%': [2195], 'piperidine/DMF': [2196], '(containing': [2197], '0.1': [2198], 'm': [2199, 2847, 3422, 3425, 3498], 'hydroxybenzotriazole)': [2200], 'sample': [2227, 2331, 3156], '(∼5': [2228], 'mg)': [2229, 2455], 'subjected': [2231], 'test': [2235, 2344, 2361, 2559, 2581], '(26Hancock': [2236, 2345], 'W.S.': [2237, 2346], 'Battersby': [2238, 2347], 'Anal.': [2240, 2349, 3325, 3767], 'Biochem.': [2241, 2350, 3326, 3768], '1976;': [2242, 2351, 2938], '71:': [2243, 2352], '260-264Crossref': [2244, 2353], '(261)': [2247, 2356], 'Scholar)': [2249, 2590, 3334, 4159, 4444], 'presence': [2252, 2337, 2527, 3248], 'primary': [2254], 'amine.': [2255], 'Fmoc-amino': [2257, 2369], 'mmol': [2260], '4-fold': [2262], 'excess)': [2263], 'activated': [2265, 2547, 3408, 3464], 'dissolution': [2267], '(2': [2270, 2283, 2452], 'followed': [2272, 2849], 'ml,': [2284], 'm)': [2286], '(340': [2292], 'μl,': [2293], 'mmol).': [2295], 'sonicated': [2299], 'min': [2302, 2502], 'resin-coupling': [2310], 'reaction': [2311, 2423], 'mixture': [2312, 2424, 2462, 2650], 'agitated': [2314], 'h': [2317, 3068, 3264], 'drained': [2320], 'tested': [2334, 2524], 'residual': [2339, 3504], 'amine': [2340, 2531, 2568, 3559], 'using': [2341, 3297, 3370, 3399, 3437, 3664, 3795, 4057, 4114, 4186, 4200, 4366, 4452], 'If': [2359, 4304], 'positive': [2363, 4306], 'aliquot': [2366], 'activated,': [2372], 'coupling': [2375, 3560, 4268], 'procedure': [2376, 2497, 3487, 3561], 'repeated.': [2378], 'Where': [2379], 'following': [2390], 'piperidine': [2392], 'treatment,': [2393], 'chloride': [2395], '(0.75': [2396, 2444], '3': [2398, 2446, 2499, 2679], 'eq)': [2399, 2447], 'together': [2415], '2,4,6-collidine': [2417], '(1.25': [2418], '5': [2420, 2714, 2739, 3467, 3594, 3637, 4084], 'eq).': [2421], 'N': [2431, 2539], 'terminus': [2432], 'methylated': [2435, 2976], 'treatment': [2437], 'triflate': [2443], 'base': [2450], 'MTBD': [2451], 'eq,': [2453], '77': [2454], 'period': [2470], 'drained,': [2474], 'repeatedly': [2485], '2-mercaptoethanol/1,8-diazabicyclo[5.4.0]undec-7-ene/DMF': [2490], '(200': [2491], 'μl/200': [2492], 'μl/4': [2493], 'Usually': [2495], 'treatments': [2503], 'until': [2504, 3469], 'there': [2505], 'no': [2507, 3165, 3563, 3654, 4395], 'more': [2508], 'yellow': [2509], 'color': [2510], 'evident': [2511], '(due': [2515], 'group).': [2519], 'secondary': [2530, 2567], 'due': [2532], 'terminus.': [2540], 'next': [2542], 'coupled': [2549], 'normal': [2552], 'manner': [2553], '(HBTU).': [2554], 'Note': [2555], 'detect': [2565], 'proline': [2570], 'acids:': [2575], 'case': [2578], 'chloranil': [2580], '(27Vojkovsky': [2582], 'Pept.': [2584, 3957], 'Res.': [2585, 3958], '8:': [2587], '236-237PubMed': [2588], 'used.': [2592], 'Cleavage': [2594], 'Purification-Upon': [2598], 'completion': [2599], 'cycles': [2605], 'N-terminal': [2607], 'deprotected': [2611], '(5': [2619], 'lastly': [2624], 'ether.': [2625], '(typically': [2628], '0.8–1.0': [2629], 'air-dried': [2632], 'overnight': [2633, 3208], 'trifluoroacetic': [2641], 'acid/dithiothreitol/triisopropylsilyl/H2O': [2642], '(90/5/2.2/2.5,': [2643], 'filtered,': [2653], 'cold': [2655], '(40': [2657], 'solution,': [2663], 'resulted': [2665], 'precipitation': [2668, 2836], 'slurry': [2674], 'centrifuged': [2676], '(3500': [2677], 'rpm,': [2678], 'min)': [2680], 'crude': [2683], 'decanting': [2688], 'ethereal': [2690], 'supernatant.': [2691], '30%': [2698], 'acetonitrile/water,': [2699], 'lyophilized.': [2704], 'lyophilized': [2706], 'purified': [2709], 'Gemini': [2712], 'C18': [2713, 2738], 'μm': [2715, 2740, 3605], 'semi-prep': [2716], 'high-performance': [2717, 2742], 'liquid': [2718, 2743], 'chromatography': [2719, 2744], 'column': [2720, 2745], '(Phenomenex:': [2721], 'dimension,': [2722, 2747], '50': [2723, 3030], '21.2': [2725], 'mm;': [2726, 2751], 'flow,': [2727, 2752], '6': [2728, 4298], 'ml/min).': [2729, 2754], 'Collected': [2730], 'fractions': [2731, 2756], 'analyzed': [2733, 4199], 'Absorbosphere': [2736], 'HD': [2737], 'analytical': [2741], '(Alltech:': [2746], '150': [2748, 3376], '3.2': [2750], '0.7': [2753], 'Pure': [2755], 'pooled': [2758], 'lyophilized,': [2760], 'confirmed': [2766], 'electrospray': [2768], 'mass': [2769, 3758], 'spectrometry.': [2770], 'Production': [2771], 'M13': [2773], 'bacteriophage': [2774], 'displaying': [2775], 'carried': [2780], 'out': [2781], 'elsewhere': [2784], '(28Casey': [2785, 2875], 'Zachariou': [2791, 2881], 'Affinity': [2793, 2883], 'Chromatography': [2794, 2884], 'Methods': [2795, 2885], 'Protocols.': [2797, 2887], '2nd': [2798, 2888], 'Ed.': [2799, 2889], 'Humana': [2800, 2890], 'Press,': [2801, 2891], 'Totowa,': [2802, 2892], 'NJ2007:': [2803, 2893], '111-136Google': [2804, 2894], 'Briefly,': [2806, 3023], 'K91': [2807], 'Escherichia': [2808], 'coli': [2809], 'harboring': [2811], 'modified': [2813], 'genome': [2815], 'fUSE5,': [2816], 'included': [2818, 3756, 4351], 'DNA': [2819], 'encoding': [2820], 'incubated': [2825, 3065, 3207], 'broth': [2827], 'culture': [2828, 3043], 'produce': [2830], 'phage.': [2831], 'Phage': [2832, 2862], 'harvested': [2834], 'polyethylene': [2838, 2842], 'glycol/NaCl': [2839], '(30%': [2840], '(w/v)': [2841], 'glycol': [2843], '8000': [2844], '(Sigma),': [2845, 3299], '2.6': [2846], 'NaCl)': [2848], 'centrifugation': [2851], 'resuspension': [2853], 'pellet': [2857], 'saline': [2860], '(PBS).': [2861], 'concentration': [2863, 3252, 3826], 'determined': [2865, 3098], 'colony-forming': [2867], 'units': [2868, 3474, 3479, 3522], 'milliliter': [2870], '(cfu/ml)': [2871], 'line': [2899], 'cultured': [2901], 'essentially': [2902], '(29Cranmer': [2906], 'Magowan': [2908], 'Liang': [2910], 'Cooke': [2914], 'B.M.': [2915], 'Trans.': [2916], '91:': [2923], '363-365Abstract': [2924], '30Trager': [2933], 'W.': [2934, 3953], 'Jensen': [2935], 'J.B.': [2936], 'Science.': [2937], '193:': [2939], '673-675Crossref': [2940], '(6184)': [2943], 'synchronized': [2949, 3048], 'sorbitol': [2951], 'lysis': [2952], 'ring': [2956], '(31Lambros': [2959], 'Vanderberg': [2961], 'J.P.': [2962, 4138], 'Parasitol.': [2964], '1979;': [2965], '65:': [2966], '418-420Crossref': [2967], '(2839)': [2970], 'analogues': [2978, 3238], 'assayed': [2980], 'their': [2982, 3348], 'diluted': [3026, 3192, 3449], 'μl': [3031, 3813], 'triplicate': [3035, 3573], 'sterile': [3037], 'flat-bottomed': [3038], 'microtiter': [3039, 3178], 'wells': [3040, 3243], '(Nunc).': [3041], 'Complete': [3042], 'media': [3044], '(50': [3045], 'schizont-stage': [3049], '(100': [3051], 'well': [3057], '(4%': [3058], 'hematocrit,': [3059], '0.3%': [3060], 'parasitemia)': [3061], 'plates': [3063, 3179, 3205], '40–42': [3067], '37': [3070], '°C': [3071, 3369, 4085], 'moist': [3074], 'atmosphere': [3075], '94%': [3077], 'N2,': [3078], '1%': [3079], 'O2,': [3080], '5%': [3081], 'CO2.': [3082], 'washing': [3084, 3217, 3275], 'ice-cold': [3086], 'frozen,': [3090], 'thawed,': [3092], 'relative': [3094, 3473, 3478, 3521, 3527], 'parasitemia': [3095], 'levels': [3096, 3510], 'assaying': [3100], 'lactate': [3103], 'dehydrogenase': [3104], '(10Kennedy': [3106], 'Absorbance': [3134], 'measured': [3136, 4271, 4361], '650': [3138], 'nm': [3139, 3154, 3159, 3164, 3170, 3597], '(A650': [3140], 'nm),': [3141], 'percent': [3144], 'inhibition': [3145], 'calculated': [3149, 3780], 'as:': [3150], '100': [3151, 4450], '-': [3152, 3157, 3168], '[(A650': [3153], 'A650': [3158, 3169], 'only)/(A650': [3163], 'control': [3167, 3440], 'only)': [3174], '100].': [3176], '96-well': [3177], '(Maxisorp,': [3180], 'Nunc)': [3181], 'coated': [3183], 'μg/ml': [3186, 3452], 'AMA1.': [3188], 'coating': [3194], 'buffer': [3195, 3372, 3577, 3635], '(15': [3196], 'mm': [3197, 3200, 3374, 3377, 3380, 3455, 3820], 'Na2CO3,': [3198], '34': [3199], 'NaHCO3,': [3201], 'pH': [3202, 3386, 3458, 3831], '9.6),': [3203], '4': [3210], '°C.': [3211, 3580], 'Unbound': [3212], 'removed': [3215, 3273, 3696], 'unbound': [3222, 3270], 'surfaces': [3223], 'blocked': [3225], '10%': [3227], 'skim': [3228], 'milk': [3229], 'powder': [3230], 'PBS.': [3232], 'N-methylated': [3236, 3349, 3930], 'duplicate': [3245], 'constant': [3251, 3617], '(∼2': [3256], '109': [3258], 'cfu/ml).': [3259], 'Following': [3260], 'incubation': [3261], 'room': [3266], 'temperature,': [3267], 'shaking,': [3269], 'PBS': [3277], '0.05%': [3278, 3383], 'Tween': [3279], '20': [3280], '(Sigma).': [3281], 'Bound': [3282], 'detected': [3285], 'horseradish': [3287], 'peroxidase-conjugated': [3288], 'anti-M13': [3289], '(1:5000,': [3291], 'Amersham': [3292], 'Biosciences).': [3293], 'Binding': [3294], 'visualized': [3296], 'tetramethylbenzidine': [3298], 'absorbance': [3302], 'read': [3304], '450': [3306], 'nm.': [3307], 'Biacore': [3309, 3660], 'T100': [3310], 'biosensor': [3311, 3567], 'instrument': [3312], '(32Papalia': [3313], 'G.A.': [3314], 'Baer': [3315], 'Luehrsen': [3317], 'K.': [3318, 4213, 4381], 'Nordin': [3319], 'Flynn': [3321], 'Myszka': [3323], 'D.G.': [3324, 3762], '2006;': [3327], '359:': [3328], '112-119Crossref': [3329], 'measure': [3338], 'kinetics': [3340], 'interaction': [3343], 'proteins': [3353], 'strains': [3356], 'falciparum.': [3359], 'All': [3360, 3566, 3659, 4079], 'immobilization': [3361, 3470, 3486], 'experiments': [3364, 3569], 'performed': [3366, 3571, 4108], '25': [3368, 3579], 'HBS-EP+': [3371, 3575, 3633], 'HEPES,': [3375], 'NaCl,': [3378], '3.4': [3379], 'EDTA,': [3381], 'surfactant': [3384], 'P20,': [3385], '7.4)': [3387], 'running': [3390, 3576, 3634], 'buffer.': [3391], 'immobilized': [3394, 3508, 3613], 'CM5': [3396], 'sensor': [3397], 'chips': [3398], 'standard': [3400], 'amine-coupling': [3401], 'chemistry.': [3402], 'carboxymethyl': [3404], 'dextran': [3405], '7-min': [3411, 3492], 'injection': [3412, 3493], 'μl/min': [3415, 3468, 3622], '1:1': [3418, 3751], 'ratio': [3419], '0.4': [3421], '1-ethy-3-(3-dimethylaminopropyl)carbodiimide': [3423], 'hydrochloride/0.1': [3424], 'N-hydroxy': [3426], 'succinimide.': [3427], 'Coupling': [3428], 'chip': [3433, 3541], 'achieved': [3436, 3511], 'manual': [3439], 'whereby': [3442], 'volumes': [3444], '(1–15': [3445], '12.5': [3451], 'sodium': [3456, 3821], 'acetate,': [3457], '4.5,': [3459], 'injected': [3461, 3611], 'over': [3462, 3612], '∼1500–2500': [3472], 'reached': [3476], '=': [3480, 3516, 3519, 3525], 'pg': [3482], 'protein/mm2).': [3484], 'completed': [3489], 'μl/min)': [3495], 'ethanolamine': [3499], '(pH': [3500], '8.5)': [3501], 'deactivate': [3503], 'reactive': [3505], 'sites.': [3506], 'Final': [3507], 'follows:': [3514, 4287], '1530,': [3517], '2705': [3520], 'W2mef': [3524, 3607], '2499': [3526], 'units.': [3528], 'experiment': [3531], 'least': [3533], 'flow': [3537, 3618, 3701, 3729], '"mock': [3545], 'surface"': [3546], 'referencing': [3548], 'purposes.': [3549], 'prepared': [3552, 3804], 'subjecting': [3554], 'present.': [3565], 'generate': [3582], 'data,': [3585], 'series': [3587], 'concentrations,': [3590], 'ranging': [3592], '320': [3596], '0.32': [3602], '40.96': [3604], 'HB3,': [3609], 'rate': [3619], '60': [3621, 3990], 'dissociation': [3627], 'monitored': [3630], 'injecting': [3632], 'min,': [3638], 'after': [3639], 'completely': [3646], 'dissociated': [3647], 'thus': [3653], 'regeneration': [3656], 'sensorgrams': [3661, 3719], 'processed': [3663, 3743, 4185], 'Scrubber': [3665, 3731], 'software': [3666, 3733], '(Version': [3667, 4188, 4194, 4202], '2,': [3668], 'available': [3669, 3799], 'Biologic': [3671], 'Software,': [3672], 'Sensograms': [3674], 'first': [3676], 'zeroed': [3677], 'y': [3680], 'axis': [3681], 'x-aligned': [3684], 'beginning': [3687], 'injection.': [3690], 'Bulk': [3691], 'refractive': [3692], 'index': [3693], 'changes': [3694], 'subtracting': [3698], 'reference': [3700, 3728], 'cell': [3702], 'responses.': [3703], 'average': [3705], 'blank': [3709, 3718], 'injections': [3710, 3716], 'subtracted': [3712], 'analyte': [3715], 'remove': [3721], 'artifacts': [3723], 'experimental': [3726], 'cells.': [3730], 'analysis': [3732, 3807], 'determine': [3737], 'ka': [3738], 'kd': [3740], 'data': [3744, 4317], 'sets': [3745], 'globally': [3747], 'fitting': [3748], 'biomolecular': [3752], 'model': [3754], 'transport': [3759], 'term': [3760], '(33Myszka': [3761], 'Jonsen': [3763], 'M.D.': [3764], 'Graves': [3765], 'B.J.': [3766], '265:': [3770], '326-330Crossref': [3771], '(110)': [3774], 'KD': [3778], 'quotient': [3783], 'kd/ka.': [3784], 'Alternatively,': [3785], 'dissociating': [3788], 'interactions,': [3789], '(KD)': [3791], 'estimates': [3792], 'steady-state': [3796], 'algorithm': [3798], 'Scrubber.': [3801], 'Samples': [3802], 'NMR': [3806, 3837, 3997], 'dissolving': [3809], '500': [3812], '95%': [3815], 'H2O/5%': [3816], '2H2O': [3817], 'acetate': [3822], 'final': [3825], '∼1.7': [3828], 'mm.': [3829], 'adjusted': [3833], '4.6–4.7.': [3835], '1H': [3836], 'spectra': [3838, 3862, 3881, 3984, 3998, 4014, 4035, 4080, 4277], 'showed': [3842, 3972], 'set': [3846], 'resonances,': [3848], 'impurities': [3852], 'non-peptidic': [3854], '(the': [3855], 'amide': [3856], 'aromatic': [3858], 'regions': [3859], 'one-dimensional': [3861], 'supplemental': [3866, 4239], 'Fig.': [3867], 'S1).': [3868], 'Additional': [3869], 'peaks': [3870, 3895], 'intensities': [3872], '<10%': [3873], 'main': [3876], 'peak': [3877, 4095], 'present': [3879], 'N-Me-Leu-8,': [3883, 4110], 'N-Me-Leu-8/N-Me-Ser-14,': [3884, 4111], 'N-Me-Val-1/N-Me-Leu-8/N-Me-Ser-14.': [3886, 4355], 'As': [3887], '>90%': [3891], 'pure,': [3892], 'additional': [3894], 'must': [3896], 'arisen': [3898], 'minor': [3900, 3978], 'conformers.': [3901], 'likely': [3904], 'origin': [3905], 'heterogeneity': [3909], 'cis-trans': [3911], 'isomerism': [3912], 'around': [3913], 'bond': [3916, 4348], 'involving': [3917], 'Leu-8;': [3922], 'observed': [3926], '(34Goodman': [3932], 'Chen': [3934], '1974;': [3942], '96:': [3943], '1479-1484Crossref': [3944], '(15)': [3947], '35Trzepalka': [3950], 'Kowalczyk': [3952], 'Lammek': [3954], '63:': [3960], '333-346Crossref': [3961], '(10)': [3964], 'Two': [3967], 'preparations': [3969], 'N-Me-Leu-8': [3971, 4029, 4353, 4407], 'identical': [3973], 'ratios': [3974], 'species.': [3979], 'Two-dimensional': [3980, 4009], 'homonuclear': [3981], 'total': [3982], 'correlation': [3983, 3996, 4276], 'spin-lock': [3987], 'ms': [3991, 4021, 4042], 'double': [3993, 4273], 'quantum': [3994, 4274], 'filtered': [3995, 4275], 'acquired': [4000, 4024, 4045], '600': [4002, 4026, 4279], 'MHz': [4003, 4048, 4280], 'Bruker': [4006, 4051, 4190, 4196], 'DRX-600': [4007], 'spectrometer.': [4008], 'enhancement': [4012, 4034], '(NOESY)': [4013], 'mixing': [4017, 4038], '250': [4020, 4041], 'also': [4023, 4044], 'MHz.': [4027], 'For': [4028, 4403], 'N-Me-Val-1/N-Me-Leu-8/N-Me-Ser-14,': [4031, 4409], '800': [4047], 'Avance': [4052], '800.': [4053], 'Water': [4054], 'suppressed': [4056], 'WATERGATE': [4059], 'pulse': [4060, 4122], '(36Piotto': [4062], 'Saudek': [4064], 'Sklenal': [4066], 'Biomol.': [4069, 4150, 4173, 4215, 4257, 4323], 'NMR.': [4070, 4151, 4174, 4216, 4258, 4324], '1992;': [4071, 4325], '661-665Crossref': [4073], '(3527)': [4076], 'collected': [4082], 'unless': [4086], 'otherwise': [4087], 'stated': [4088], 'referenced': [4091], 'impurity': [4094], '0.15': [4097], 'ppm': [4098], 'water': [4102], 'Translational': [4104], 'diffusion': [4105], 'measurements': [4106], 'N-Me-Val-1/N-Me-Leu-8/N-Me-Ser-14': [4113], 'pulsed': [4116], 'field': [4117], 'gradient': [4118], 'longitudinal': [4119], 'eddy-current': [4120], 'delay': [4121], '(37Gibbs': [4124], 'Johnson': [4126], 'C.S.': [4127], 'Magn.': [4129, 4435], 'Reson.': [4130, 4436], '1991;': [4131, 4259], '93:': [4132], '395-402Google': [4133], '38Dingley': [4135], 'Mackay': [4137], 'Chapman': [4139], 'B.E.': [4140], 'M.B.': [4142], 'Kuchel': [4143], 'P.W.': [4144], 'Hambly': [4145], 'B.D.': [4146], 'King': [4147], 'G.F.': [4148], '6:': [4153, 4218], '321-328Crossref': [4154], '(121)': [4157], 'implemented': [4161], 'Yao': [4163], 'et': [4164], 'al.': [4165], '(39Yao': [4166], 'Howlett': [4168], '109-119Crossref': [4177], '(112)': [4180], 'Spectra': [4183], 'XWINNMR': [4187], '3.5,': [4189], 'Biospin)': [4191, 4197], 'TOPSPIN': [4193], '1.3,': [4195], 'XEASY': [4201, 4363], '1.3.13)': [4203], '(40Bartels': [4204], 'T.H.': [4207], 'Billeter': [4208], 'Guntert': [4210, 4378], 'Wuthrich': [4212, 4380], '1-10Crossref': [4219], '(1604)': [4222], 'Chemical': [4225], 'shift': [4226], 'assignments': [4227], 'conformation': [4231], 'tabulated': [4236], 'material': [4240], 'deposited': [4244], 'BioMagResBank': [4247], '(41Seavey': [4248], 'B.R.': [4249], 'Farr': [4250], 'E.A.': [4251], 'Westler': [4252], 'W.M.': [4253], 'Markley': [4254], '1:': [4260], '217-236Crossref': [4261], '(346)': [4264], '3JHNHA': [4267], 'constants': [4269], 'converted': [4282], 'dihedral': [4284], 'restraints': [4285, 4349], '3JHNHα': [4288, 4296], '>': [4289], '8': [4290], 'Hz,': [4291, 4299], 'φ': [4292, 4300, 4307, 4333], '=-120': [4293], '±': [4294, 4302], '40°;': [4295], '<': [4297], '=-60': [4301], '30°.': [4303], 'angle': [4308, 4345], 'excluded': [4311], 'basis': [4314], 'NOE': [4316, 4358], '(42Ludvigsen': [4318], 'Poulsen': [4320], '227-233Crossref': [4327], '(86)': [4330], 'angles': [4334], 'restricted': [4336], '-180': [4340], '0°.': [4342], 'χ1': [4344], 'Intensities': [4356], 'cross-peaks': [4359], 'calibrated': [4365], 'CALIBA': [4368, 4416], 'macro': [4369, 4417], 'program': [4372], 'CYANA': [4373, 4419], '(version': [4374], '1.0.6)': [4375], '(43Herrmann': [4376], '319:': [4386], '209-227Crossref': [4387], '(1329)': [4390], 'NOEs': [4393], 'providing': [4394], 'restraint': [4396], 'representing': [4398], 'fixed': [4399], 'distances': [4400], 'removed.': [4402], 'structure': [4404], 'calculations': [4405], 'constraint': [4411], 'list': [4412], 'resulting': [4413], 'directly': [4422], 'XPLOR-NIH': [4424], '(44Schwieters': [4425], 'C.D.': [4426], 'Kuszewski': [4427], 'J.J.': [4428], 'Tjandra': [4429], 'N.': [4430], 'Marius': [4431], 'Clore': [4432], '2003;': [4437], '160:': [4438], '65-73Crossref': [4439], '(1869)': [4442], 'calculate': [4446], 'family': [4448], 'structures': [4451], 'simulated': [4454], 'annealing': [4455], 'script.': [4456], 'library': [4458], 'files': [4459], 'supplied': [4460], 'XPLOR-NI': [4462]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2050355159', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 7}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 6}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2025-01-10T05:02:47.947710', 'created_date': '2016-06-24'}