Cholecystokinin Induces Caspase Activation and Mitochondrial Dysfunction in Pancreatic Acinar Cells

Name: Work Video:
Duration: 3 min 30 s
Anna S. Gukovskaya; Ilya Gukovsky; Yoon Jung; Michelle Mouria; Stephen J. Pandol
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1092, 1125, 1127, 1161, 1164, 1264, 1496, 1993, 2297, 2318, 2347, 2357, 2374, 2376, 2404, 2505, 2518, 2538, 2551, 2613, 2617, 2645, 2673, 2704, 2709, 2789, 2804, 2810, 2833, 2854, 2868, 2927, 3033, 3062, 3125, 3177, 3193, 3211, 3220, 3255, 3292, 3316, 3355, 3387, 3399, 3410, 3451, 3457, 3464, 3567, 3609, 3722, 3870, 3883, 3908, 3911, 3968, 4012, 4033, 4040, 4045, 4058, 4084, 4087, 4106, 4171, 4229, 4239, 4278, 4309, 4396], 'necrosis': [2, 150, 176, 201, 349, 375, 1093, 1126, 1491, 2086, 2346, 2356, 2375, 2984], 'are': [3, 110, 141, 202, 309, 340, 489, 685, 1365, 3040, 3309, 3954], 'critical': [4, 203], 'parameters': [5, 134, 204, 333], 'of': [6, 10, 16, 30, 73, 135, 143, 187, 197, 205, 209, 215, 229, 272, 334, 342, 386, 396, 424, 482, 487, 557, 573, 620, 637, 687, 708, 931, 1098, 1119, 1130, 1139, 1153, 1158, 1170, 1256, 1266, 1307, 1374, 1403, 1494, 1500, 1508, 1677, 1777, 1794, 1872, 1877, 1934, 1972, 1988, 1995, 2045, 2078, 2151, 2154, 2351, 2368, 2379, 2390, 2530, 2747, 2850, 2857, 2883, 2892, 2990, 3028, 3045, 3075, 3077, 3252, 3276, 3394, 3508, 3554, 3585, 3588, 3592, 3616, 3639, 3797, 3961, 3988, 4000, 4079, 4102, 4108, 4161, 4200, 4210, 4275, 4307, 4316, 4324, 4332, 4346, 4359], 'pancreatitis,': [7, 206], 'the': [8, 107, 161, 185, 195, 207, 306, 360, 384, 394, 574, 781, 786, 1117, 1122, 1128, 1131, 1134, 1165, 1254, 1273, 1378, 1489, 1498, 1675, 1771, 1783, 1795, 1802, 1878, 1925, 1935, 2076, 2193, 2331, 2362, 2366, 2371, 2377, 2380, 2383, 2623, 2698, 2820, 2889, 2988, 3026, 3043, 3078, 3137, 3156, 3221, 3263, 3270, 3277, 3453, 3506, 3509, 3550, 3563, 3568, 3583, 3819, 3886, 3959, 3965, 3969, 3989, 4081, 4109, 4273, 4292, 4314, 4333, 4340], 'mechanisms': [9, 109, 208, 308, 930, 2077, 2394], 'which': [11, 210, 1939, 3282, 3756], 'remain': [12, 211, 937], 'unknown.': [13, 212], 'Many': [14, 213, 1137], 'characteristics': [15, 214, 1138], 'pancreatitis': [17, 188, 216, 387, 494, 647, 692, 936, 1099, 1140, 1257], 'can': [18, 182, 217, 381, 1141, 1260, 1351, 1914, 1923, 2028, 2360], 'be': [19, 218, 1142, 1790, 1915, 1977], 'studied': [20, 219, 1143], 'in': [21, 23, 44, 68, 101, 145, 154, 171, 189, 220, 222, 243, 267, 300, 344, 353, 370, 388, 550, 634, 784, 935, 1095, 1101, 1103, 1108, 1144, 1253, 1272, 1355, 1370, 1673, 1780, 2089, 2138, 2149, 2214, 2287, 2330, 2339, 2341, 2387, 2400, 2406, 2507, 2534, 2543, 2594, 2662, 2711, 2729, 2791, 2847, 2863, 2880, 2910, 3080, 3086, 3102, 3111, 3117, 3136, 3155, 3179, 3234, 3357, 3413, 3645, 3709, 3729, 3794, 3834, 3885, 3900, 3980, 4089, 4166, 4186, 4220, 4291, 4300, 4339, 4348], 'vitro': [22, 221], 'pancreatic': [24, 46, 103, 223, 245, 302, 429, 1147, 1356, 2216, 2289, 2332, 2410, 2587, 2783, 3700, 4092, 4168, 4188, 4221, 4349], 'acini': [25, 224, 1148, 2411, 2502, 2588, 2784, 3169, 3701], 'treated': [26, 225, 2674], 'with': [27, 194, 226, 393, 643, 1150, 2511, 2637, 2675, 2689, 2702, 2707, 2922, 2929, 2972, 3053, 3099, 3123, 3131, 3173, 3287, 3349, 3420, 3532, 3573, 3604, 3625, 3749, 3772, 3800, 3830, 3904, 3977, 4149, 4173, 4270, 4286, 4313, 4336, 4393], 'high': [28, 227, 555, 1985, 2836], 'doses': [29, 228, 481, 556, 1152], 'cholecystokinin': [31, 230, 398], '(CCK).': [32, 231], 'We': [33, 122, 232, 321, 940, 2278], 'show': [34, 233], 'here': [35, 234, 2280], 'that': [36, 124, 140, 160, 235, 323, 339, 359, 484, 569, 1089, 1981, 2033, 2035, 2227, 2281, 2335, 4075], 'CCK': [37, 75, 236, 274, 483, 558, 630, 1348, 2282, 2311], 'stimulates': [38, 237, 2283], 'apoptosis': [39, 129, 238, 328, 1091, 1120, 1354, 1371, 1669, 1973, 2079, 2137, 2369], 'death': [41, 170, 240, 369, 684, 934, 2284, 2405], 'signaling': [42, 163, 241, 362, 1363, 1503, 1990, 2285, 2393], 'pathways': [43, 164, 242, 363, 1364, 1402, 2286], 'rat': [45, 244, 2288, 2409, 4091], 'acinar': [47, 104, 117, 137, 155, 246, 303, 316, 336, 354, 430, 682, 932, 1274, 1357, 2217, 2290, 2333, 2401, 3820, 4093, 4169, 4222, 4350], 'cells,': [48, 247, 2291, 4322], 'including': [49, 248, 2292], 'caspase': [50, 249, 1404, 2293, 3278], 'activation,': [51, 250, 2294], 'cytochromec': [52, 251, 2295, 4021], 'release,': [53, 252, 2296], 'mitochondrial': [55, 58, 77, 97, 120, 254, 257, 276, 296, 319, 1671, 1796, 1873, 1879, 1926, 2038, 2298, 2304, 2313], 'depolarization.': [56, 255], 'The': [57, 157, 256, 356, 1246, 2211, 2303, 2523, 2658, 2714, 2906, 2963, 2970, 3035, 3056, 3091, 3140, 3152, 3168, 3197, 3225, 3297, 3307, 3344, 3401, 3423, 3439, 3528, 3556, 3577, 3590, 3614, 3725, 3765, 3875, 3949, 3998, 4289], 'dysfunction': [59, 258, 1874, 1913, 2039, 2305], 'is': [60, 259, 563, 631, 1248, 1372, 1481, 1773, 1804, 1875, 1974, 2073, 2097, 2101, 2189, 2199, 2202, 2219, 2306, 3757, 4098], 'mediated': [61, 260, 1791, 1916, 2307], 'by': [62, 180, 261, 379, 428, 554, 1792, 1917, 1928, 1979, 2081, 2091, 2142, 2197, 2204, 2308, 2591, 2630, 2647, 2686, 2787, 2818, 2872, 2888, 2967, 2987, 3050, 3060, 3072, 3160, 3427, 3504, 3561, 3582, 3595, 3619, 3648, 3759, 3792, 3881, 3896, 3974, 4100, 4328], 'upstream': [63, 262, 1918, 2309], 'caspases': [64, 114, 125, 147, 181, 263, 313, 324, 346, 380, 1379, 1584, 1589, 2325, 2343, 4183], '(possibly': [65, 264], 'caspase-8)': [66, 265], 'and,': [67, 266, 1100, 1359], 'turn,': [69, 268, 1781], 'leads': [70, 269], 'to': [71, 270, 491, 645, 1172, 1506, 1976, 2084, 2103, 2135, 2221, 2301, 2323, 3065, 3633, 3635, 3761, 4154, 4237], 'activation': [72, 95, 153, 179, 271, 294, 352, 378, 1265, 1373, 1405, 1507, 1776, 1994, 2150, 2350, 2359, 4078, 4097], 'caspase-3.': [74, 273], 'causes': [76, 275, 1941, 2312], 'alterations': [78, 98, 277, 297, 2314], 'through': [79, 278, 1483, 2315], 'both': [80, 279, 688, 1090, 2316, 2866, 3452, 4080, 4276], 'permeability': [81, 88, 280, 287, 406, 1797], 'transition': [82, 89, 281, 288, 407, 1798], 'pore-dependent': [83, 282], '(cytochrome': [84, 283], 'c': [85, 284, 1768, 1787, 1943, 2047], 'release)': [86, 285], 'pore-independent': [90, 289], '(mitochondrial': [91, 290, 3455], 'depolarization)': [92, 291], 'mechanisms.': [93, 292, 2320], 'Caspase': [94, 293, 4030], 'also': [99, 131, 298, 330, 632, 2027, 2326, 4164], 'occur': [100, 299, 1094], 'untreated': [102, 116, 301, 315, 4167, 4287, 4321], 'cells;': [105, 304], 'however,': [106, 305], 'underlying': [108, 307], 'different.': [111, 310], 'In': [112, 311, 2321, 4320], 'particular,': [113, 146, 312, 345, 1102, 1674, 2090, 2342], 'protect': [115, 314], 'cells': [118, 317, 431, 1358, 1980, 2141, 2218, 2524, 2907, 2971, 3052, 3345, 3402, 3529, 3557, 3596, 3620, 3798, 3821, 3876, 3976, 4094, 4170, 4223, 4351], 'from': [119, 318, 1945, 2865, 3030, 3925, 4015, 4023, 4027, 4036, 4049, 4055, 4063, 4069, 4152], 'damage.': [121, 320], 'found': [123, 322], 'not': [126, 325, 1983, 2190], 'only': [127, 326], 'mediate': [128, 327], 'but': [130, 329], 'regulate': [132, 149, 165, 331, 348, 364, 2327, 2345], 'other': [133, 332, 635, 1135, 1267, 2205, 2328, 2384], 'CCK-induced': [136, 172, 335, 371, 4305], 'cell': [138, 167, 337, 366, 683, 933, 1168, 1262, 1275, 2334, 2349, 2402, 2983, 3198, 3646], 'injury': [139, 168, 338, 367, 1263, 2403], 'characteristic': [142, 341, 1871], 'pancreatitis;': [144, 343, 638, 2340], 'negatively': [148, 347, 2344], 'trypsin': [152, 178, 351, 377, 1174, 1259, 2358, 3760, 3786, 3873], 'cells.': [156, 355, 4288], 'results': [158, 357], 'suggest': [159, 358], 'observed': [162, 361, 1115, 2386], 'parenchymal': [166, 365], 'pancreatitis.': [173, 372, 1105, 2391, 2407], 'Protection': [174, 373], 'against': [175, 374, 2355, 4009, 4020], 'explain': [183, 382, 2361], 'why': [184, 383], 'severity': [186, 385, 1129, 2378], 'experimental': [190, 389, 567, 691, 2388], 'models': [191, 390, 636, 1097, 1110, 2389], 'correlates': [192, 391], 'inversely': [193, 392], 'extent': [196, 395, 1118, 2367], 'apoptosis.': [198, 397, 2302], '7-amino-4-methylcoumarin': [399], 'aristolochic': [400, 4043], 'acid': [401, 414, 3032, 4044], '3-[(3-cholamidopropyl)dimethylammonio]-1-propane-sulfonate': [402], 'cyclosporin': [403, 4046], 'A': [404, 1367, 1664, 4047], '3,3′-dihexyloxacarbocyanine': [405, 3511], 'pore': [408, 1799], 'Z-Ile-Glu(OMe)-Thr-Asp(Ome)-CH2F': [409], 'Z-Val-Ala-Asp(OMe)-CH2F': [410], 'lactate': [411], 'dehydrogenase': [412], '4-morpholineethanesulfonic': [413], 'protein': [415, 1937, 2226, 4060], 'kinase': [416], 'C': [417, 2230], 'Cholecystokinin': [418], '(CCK)1is': [419], 'a': [420, 564, 1501, 1931, 2144, 2222, 2415, 2528, 2544, 2595, 3132, 3206, 3235, 3284, 3302, 3414, 3600, 3636, 3649, 3705, 3750, 3762, 3781, 3835, 4225, 4317, 4329], 'major': [421, 1401, 1666], 'physiological': [422], 'regulator': [423], 'digestive': [425, 1270], 'enzyme': [426], 'secretion': [427, 488, 3917, 3953], '(1Wank': [432, 2231], 'S.A.': [433, 445, 498, 2232, 2244], 'Am.': [434, 736, 791, 890, 903, 922, 1004, 1053, 1185, 1198, 1217, 1237, 1335, 2233, 2456, 2475, 3665, 3810], 'J.': [435, 598, 724, 735, 737, 763, 764, 790, 792, 818, 819, 869, 891, 904, 923, 983, 1005, 1054, 1186, 1199, 1218, 1238, 1336, 1384, 1413, 1448, 1516, 1551, 1597, 1632, 1683, 1718, 1827, 1903, 1954, 2016, 2116, 2118, 2172, 2234, 2435, 2457, 2476, 2489, 2574, 2770, 2897, 2952, 3009, 3328, 3488, 3666, 3689, 3811, 4118, 4246, 4253, 4368, 4375], 'Physiol.': [436, 470, 523, 892, 905, 924, 1006, 1055, 1187, 1200, 1219, 1239, 1337, 1758, 1815, 1891, 2235, 2269, 2458, 2477, 3517, 3540, 3667, 3812], '1998;': [437, 739, 794, 893, 1007, 1188, 1338, 1449, 1552, 1633, 1719, 1759, 1816, 1892, 1956, 2017, 2236, 2459, 3491, 3668], '274:': [438, 1388, 1417, 1520, 1601, 1687, 2237, 3332, 4257, 4379], 'G607-G613PubMed': [439, 2238], 'Google': [440, 464, 477, 517, 530, 546, 591, 603, 678, 732, 750, 772, 805, 827, 853, 878, 897, 910, 928, 967, 992, 1011, 1041, 1060, 1085, 1192, 1205, 1223, 1244, 1290, 1342, 1398, 1427, 1455, 1478, 1530, 1558, 1581, 1611, 1639, 1662, 1697, 1725, 1748, 1765, 1822, 1834, 1851, 1868, 1898, 1910, 1967, 2023, 2070, 2129, 2186, 2239, 2263, 2276, 2444, 2463, 2481, 2499, 2583, 2779, 2904, 2961, 3018, 3342, 3502, 3524, 3547, 3672, 3697, 3816, 3947, 4144, 4267, 4389], 'Scholar,': [441, 465, 518, 531, 592, 604, 717, 733, 751, 806, 828, 854, 879, 898, 911, 968, 993, 1012, 1042, 1061, 1193, 1206, 1224, 1291, 1316, 1428, 1456, 1531, 1559, 1612, 1640, 1698, 1726, 1749, 1823, 1835, 1852, 1899, 2240, 2264, 2445, 2464, 2482, 3673], '2Jensen': [442, 2241], 'R.T.': [443, 496, 2242, 2486], 'Wank': [444, 497, 2243], 'Rowley': [446, 499, 2245], 'W.H.': [447, 500, 2246], 'Sato': [448, 501, 2247], 'S.': [449, 502, 651, 721, 757, 759, 812, 814, 836, 866, 950, 980, 1028, 1432, 1535, 1616, 1702, 2000, 2122, 2248, 2432, 2571, 2767, 2949, 3006, 3675, 3687, 3936, 4136], 'Gardner': [450, 503, 2249, 2487], 'J.D.': [451, 504, 2250, 2488], 'Trends': [452, 505, 2251], 'Pharmacol.': [453, 506, 2252], 'Sci.': [454, 507, 2253, 4134], '1989;': [455, 508, 2254, 3941], '10:': [456, 509, 2255, 3942], '418-423Abstract': [457, 510, 2256], 'Full': [458, 511, 670, 672, 742, 744, 797, 799, 847, 961, 1033, 1035, 1390, 1392, 1419, 1421, 1522, 1524, 1603, 1605, 1689, 1691, 1959, 1961, 2178, 2180, 2257, 2495, 3334, 3336, 3494, 3496, 4259, 4261, 4381, 4383], 'Text': [459, 512, 671, 673, 743, 745, 798, 800, 848, 962, 1034, 1036, 1391, 1393, 1420, 1422, 1523, 1525, 1604, 1606, 1690, 1692, 1960, 1962, 2179, 2181, 2258, 2496, 3335, 3337, 3495, 3497, 4260, 4262, 4382, 4384], 'PDF': [460, 513, 674, 746, 801, 849, 963, 1037, 1394, 1423, 1526, 1607, 1693, 1963, 2182, 2259, 2497, 3338, 3498, 4263, 4385], 'PubMed': [461, 474, 514, 527, 543, 588, 675, 729, 747, 769, 802, 824, 850, 875, 896, 909, 964, 989, 1010, 1038, 1059, 1082, 1191, 1204, 1243, 1287, 1341, 1395, 1424, 1452, 1475, 1527, 1555, 1578, 1608, 1636, 1659, 1694, 1722, 1745, 1762, 1819, 1831, 1848, 1865, 1895, 1907, 1964, 2020, 2067, 2183, 2260, 2273, 2441, 2462, 2498, 2580, 2776, 2901, 2958, 3015, 3339, 3499, 3521, 3544, 3671, 3694, 3944, 4141, 4264, 4386], 'Scopus': [462, 475, 515, 528, 544, 589, 676, 730, 748, 770, 803, 825, 851, 876, 965, 990, 1039, 1083, 1288, 1396, 1425, 1453, 1476, 1528, 1556, 1579, 1609, 1637, 1660, 1695, 1723, 1746, 1763, 1820, 1832, 1849, 1866, 1896, 1908, 1965, 2021, 2068, 2184, 2261, 2274, 2442, 2581, 2777, 2902, 2959, 3016, 3340, 3500, 3522, 3545, 3695, 3945, 4142, 4265, 4387], '(164)': [463, 516, 2262], '3Williams': [466, 519, 2265], 'J.A.': [467, 520, 2266, 3514, 3537], 'Annu.': [468, 521, 1467, 1570, 1651, 1737, 1756, 1813, 1889, 2059, 2267, 3515, 3538], 'Rev.': [469, 522, 1468, 1571, 1652, 1738, 1757, 1814, 1841, 1858, 1890, 2060, 2268, 3516, 3539], '2001;': [471, 524, 1845, 1862, 2270, 3518, 3541], '63:': [472, 525, 2271, 3519, 3542], '77-97Crossref': [473, 526, 2272, 3520, 3543], '(194)': [476, 529, 2275, 3523, 3546], 'Scholar).': [478, 547, 629, 679, 773, 1245, 1343, 1399, 1479, 1582, 1663, 1766, 1869, 1911, 1968, 2024, 2071, 2130, 2187, 2277, 2500, 2584, 2780, 2905, 2962, 3019, 3343, 3698, 3817, 3948, 4145, 4268, 4390], 'However,': [479, 2025], 'supraphysiological': [480, 1151], 'cause': [485, 646, 1261, 2037], 'inhibition': [486], 'injurious': [490], 'pancreas,': [492], 'causing': [493], '(2Jensen': [495], '4Steer': [532], 'M.L.': [533, 578, 1052, 1236, 1277, 1334], "Baillière's": [534, 579, 1278], 'Best': [535, 580, 1279], 'Pract.': [536, 581, 1280], 'Res.': [537, 582, 1281], 'Clin.': [538, 583, 870, 984, 1282, 2436, 2575, 2771, 2953, 3010], 'Gastroenterol.': [539, 584, 1283], '1999;': [540, 585, 667, 906, 1201, 1240, 1284, 1387, 1416, 1472, 1519, 1575, 1600, 1656, 1686, 1742, 1828, 1904, 2064, 3331, 4256, 4378], '13:': [541, 586, 1285], '213-225Crossref': [542, 587, 1286], '(68)': [545, 590, 1289], 'Pancreatitis': [548], 'induced': [549, 2080, 4077], 'rats': [551], 'mice': [553], 'or': [559, 2201], 'its': [560, 4103, 4202, 4360], 'analogue,': [561], 'cerulein,': [562], 'widely': [565], 'used': [566, 1978, 3465], 'model': [568], 'mimics': [570], 'many': [571], 'features': [572], 'human': [575, 689], 'disease': [576, 1132, 2381], '(4Steer': [577, 1276], '5Lerch': [593], 'M.M.': [594, 1322], 'Adler': [595, 1331], 'G.': [596, 1332, 1751, 1808, 1856, 1884, 2159, 3934, 4128], 'Int.': [597], 'Pancreatol.': [599], '1994;': [600, 726, 3813], '15:': [601, 1473, 1576, 1657, 1743, 2065], '159-170PubMed': [602], '6Topazian': [605, 1292], 'M.': [606, 694, 753, 755, 808, 810, 862, 919, 976, 1050, 1069, 1077, 1214, 1232, 1293, 1326, 1462, 1565, 1646, 1732, 1755, 1812, 1825, 1888, 1901, 2054, 2120, 2161, 2163, 2428, 2472, 2567, 2763, 2945, 3002, 3483, 4244, 4366], 'Gorelick': [607, 695, 1294], 'F.S.': [608, 696, 1295], 'Yamada': [609, 697, 1296], 'T.': [610, 698, 1024, 1073, 1297, 2108, 3677, 3679, 4114], 'Aplers': [611, 699, 1298], 'D.H.': [612, 700, 1299], 'Laine': [613, 701, 1300], 'L.': [614, 702, 1228, 1301, 1324, 4122], 'Owyang': [615, 703, 1302], 'C.': [616, 704, 1303, 1430, 1533, 1614, 1700, 1998], 'Powell': [617, 705, 1304], 'D.W.': [618, 706, 1305], 'Textbook': [619, 707, 1306], 'Gastroenterology.': [621, 666, 709, 843, 957, 1029, 1308], 'Lippincott': [622, 710, 1309], 'Willimas': [623, 711, 1310], '&': [624, 712, 1311], 'Wilkins,': [625, 713, 1312], 'Philadelphia,': [626, 714, 1313], 'PA1999:': [627, 715, 1314], '2121-2150Google': [628, 716, 1315], 'involved': [633], 'for': [639, 1668, 1775, 2652, 2679, 2822, 2877, 2919, 3037, 3096, 3128, 3144, 3202, 3213, 3268, 3305, 3405, 3433, 3444, 3466, 3622, 3784, 3824, 3951, 4218], 'example,': [640, 1921], 'it': [641], 'synergizes': [642], 'ethanol': [644], '(7Pandol': [648], 'S.J.': [649, 868, 889, 921, 982, 1003, 1026, 1184, 1216, 2434, 2455, 2474, 2484, 2573, 2769, 2951, 3008, 3664, 3809, 3932], 'Periskic': [650], 'Gukovsky': [652, 835, 857, 865, 916, 949, 971, 979, 1211, 2423, 2431, 2469, 2562, 2570, 2758, 2766, 2940, 2948, 2997, 3005], 'I.': [653, 858, 881, 917, 972, 995, 1176, 1212, 1458, 1561, 1642, 1728, 2050, 2424, 2447, 2470, 2563, 2759, 2941, 2998, 3656], 'Zaninovic': [654, 859, 886, 973, 1000, 1017, 1181, 2425, 2452, 2564, 2760, 2942, 2999, 3661], 'V.': [655, 860, 887, 913, 974, 1001, 1018, 1182, 1208, 2426, 2453, 2466, 2565, 2761, 2943, 3000, 3662], 'Jung': [656], 'Y.': [657, 659, 1075], 'Zong': [658], 'Solomon': [660], 'T.E.': [661], 'Gukovskaya': [662, 831, 882, 914, 945, 996, 1177, 1209, 2448, 2467, 3657], 'A.S.': [663, 832, 856, 883, 915, 946, 970, 997, 1014, 1178, 1210, 2422, 2449, 2468, 2561, 2757, 2939, 2996, 3658, 3807], 'Tsukamoto': [664], 'H.': [665, 1460, 1563, 1644, 1730, 1948, 2052, 2114, 3681], '117:': [668], '706-716Abstract': [669], '(192)': [677], 'Inflammation': [680], 'hallmarks': [686], '(6Topazian': [693], '8Steinberg': [718], 'W.': [719], 'Tenner': [720], 'N.': [722, 1854], 'Engl.': [723], 'Med.': [725], '330:': [727], '1198-1210Crossref': [728], '(864)': [731], '9Norman': [734], 'Surg.': [738, 793], '175:': [740, 795], '76-83Abstract': [741, 796], '(672)': [749, 804], '10Bhatia': [752, 807], 'Brady': [754, 809], 'Shokuhi': [756, 811], 'Christmas': [758, 813], 'Neoptolemos': [760, 815], 'J.P.': [761, 816], 'Slavin': [762, 817], 'Pathol.': [765, 820], '2000;': [766, 821, 925, 1220, 2175, 2478], '190:': [767, 822, 2127], '117-125Crossref': [768, 823], '(452)': [771, 826], 'Although': [774], 'significant': [775], 'progress': [776], 'has': [777], 'been': [778, 1407], 'achieved': [779], 'over': [780], 'past': [782], 'decade': [783], 'understanding': [785], 'inflammatory': [787], 'response': [788], '(9Norman': [789], '11Sandoval': [829], 'D.': [830, 864, 944, 978, 1020, 2110, 2157, 2430, 2569, 2765, 2947, 3004], 'Reavey': [833, 947], 'P.': [834, 840, 948, 954, 1016], 'Sisk': [837, 951], 'A.': [838, 952, 1048, 1434, 1537, 1618, 1704, 2002, 4137], 'Braquet': [839, 953], 'Pandol': [841, 867, 888, 920, 955, 981, 1002, 1025, 1183, 1215, 2433, 2454, 2473, 2572, 2768, 2950, 3007, 3663, 3808], 'S.P.': [842, 956], '1996;': [844, 958, 1030, 4138], '111:': [845, 959], '1081-1091Abstract': [846, 960], '(226)': [852, 966], '12Gukovskaya': [855, 969], 'Song': [861, 975, 2427, 2566, 2762, 2944, 3001], 'Sandoval': [863, 977, 1019, 2429, 2568, 2764, 2946, 3003], 'Invest.': [871, 985, 2437, 2576, 2772, 2954, 3011], '1997;': [872, 986, 1079, 2438, 2577, 2773, 2955, 3012], '100:': [873, 987, 2439, 2578, 2774, 2956, 3013], '1853-1862Crossref': [874, 988, 2440, 2579, 2775, 2957, 3014], '(340)': [877, 991, 2443, 2582, 2778, 2960, 3017], '13Gukovsky': [880, 994, 2446], 'Blinman': [884, 998, 1179, 2450, 3659], 'T.A.': [885, 999, 1180, 2451, 3660], '275:': [894, 1008, 1189, 1339, 2176, 2460, 3669], 'G1402-G1414Crossref': [895, 1009, 1190, 2461, 3670], '14Han': [899, 1194], 'B.': [900, 1195, 1318, 1753, 1810, 1886], 'Logsdon': [901, 1196], 'C.D.': [902, 1197], '277:': [907, 1202], 'C74-C82Crossref': [908, 1203], '15Zaninovic': [912, 1207, 2465], 'Mouria': [918, 1213, 2471], '279:': [926, 1221, 2479], 'G666-G676PubMed': [927, 1222, 2480], 'Scholar),': [929], 'largely': [938], 'unexplored.': [939], 'others': [942], '(11Sandoval': [943], '16Gukovskaya': [1013], 'Perkins': [1015], 'Rutherford': [1021], 'R.': [1022, 1065, 1067], 'Fitzsimmons': [1023], 'Poucell-Hatton': [1027], '110:': [1031], '875-884Abstract': [1032], '(146)': [1040], '17Kaiser': [1043], 'A.M.': [1044], 'Saluja': [1045, 1049, 1319], 'A.K.': [1046, 1226, 1320], 'Sengupta': [1047], 'Steer': [1051, 1235, 1333], '1995;': [1056, 2126], '269:': [1057], 'C1295-C1304Crossref': [1058], '18Fujimoto': [1062], 'K.': [1063, 2112, 2895, 3683, 3685], 'Hosotani': [1064], 'Doi': [1066], 'Wada': [1068], 'Lee': [1070, 1229, 1327], 'J.U.': [1071], 'Koshiba': [1072], 'Miyamoto': [1074], 'Imamura': [1076], 'Digestion.': [1078], '58:': [1080], '421-430Crossref': [1081], '(33)': [1084], 'Scholar)': [1086, 3503, 3525, 3548], 'have': [1087, 1406, 1984], 'demonstrated': [1088], 'various': [1096], 'cerulein-induced': [1104], 'Of': [1106, 4179], 'note,': [1107, 4180], 'these': [1109], 'an': [1111, 1250, 2397, 3358, 3710, 3730], 'inverse': [1112, 2363], 'correlation': [1113, 2364], 'was': [1114, 2132, 2628, 2660, 2700, 2750, 2870, 2985, 3022, 3070, 3265, 3272, 3299, 3441, 3473, 3565, 3570, 3579, 3597, 3631, 3643, 3778, 3790, 3891, 3918, 3991, 4026, 4054, 4062, 4163, 4311, 4326, 4355], 'between': [1116, 2365, 3958], 'on': [1121, 1133, 2370, 2382, 2720, 2914, 3205, 3408], 'one': [1123, 2372], 'hand': [1124, 2373, 2385], 'hand.': [1136], 'vitroin': [1145], 'isolated': [1146, 2586, 2782, 4090], 'stimulated': [1149, 4198], 'CCK,': [1154], 'such': [1155, 1487, 1590], 'as': [1156, 1488, 1591, 2209, 2556, 2752, 2934, 3025, 3042, 3311, 3321, 3475, 3652, 3802, 3928, 3956, 4357], 'up-regulation': [1157], 'pro-inflammatory': [1159], 'cytokines': [1160], 'adhesion': [1162], 'molecules,': [1163], 'pathological,': [1166], 'intra-acinar': [1167, 2348], 'conversion': [1169], 'trypsinogen': [1171], 'active': [1173, 4111, 4182], '(13Gukovsky': [1175, 3655], '19Saluja': [1225], 'Bhagat': [1227, 1323], 'H.S.': [1230, 1328], 'Bhatia': [1231, 1325], 'Frossard': [1233, 1329], 'J.L.': [1234, 1330, 3487], '276:': [1241], 'G835-G842Crossref': [1242], 'latter': [1247], 'considered': [1249, 2980, 3632, 4005], 'important': [1251, 2398], 'event': [1252, 1369], 'development': [1255], 'because': [1258], 'potentially': [1268], 'harmful': [1269], 'enzymes': [1271], '20Hofbauer': [1317], 'Lerch': [1321], 'G352-G362Crossref': [1340], 'It': [1344, 2188, 4391], 'remains': [1345], 'unknown': [1346], 'whether': [1347, 2192], '(or': [1349], 'cerulein)': [1350], 'directly': [1352, 1586, 2036], 'induce': [1353], 'if': [1360], 'so,': [1361], 'what': [1362], 'involved.': [1366], 'central': [1368], 'specific': [1375, 3258, 3751], 'cysteine': [1376], 'proteases,': [1377], '(21Wolf': [1380, 1409, 1512, 1593], 'B.B.': [1381, 1410, 1513, 1594, 1680, 4248, 4370], 'Green': [1382, 1411, 1514, 1595, 1681, 1838, 3326, 4249, 4371], 'D.R.': [1383, 1412, 1515, 1596, 1682, 1839, 3327, 4250, 4372], 'Biol.': [1385, 1414, 1471, 1517, 1574, 1598, 1655, 1684, 1741, 1844, 1861, 2063, 2173, 2490, 3329, 3489, 4254, 4376], 'Chem.': [1386, 1415, 1518, 1599, 1685, 2174, 2491, 3330, 3490, 4255, 4377], '20049-20052Abstract': [1389, 1418, 1521, 1602, 1688], '(863)': [1397, 1426, 1529, 1610, 1696], 'Two': [1400], 'identified': [1408], '22Scaffidi': [1429, 1532, 1613, 1699], 'Fulda': [1431, 1534, 1615, 1701, 1999], 'Srinivasan': [1433, 1536, 1617, 1703, 2001], 'Friesen': [1435, 1538, 1619, 1705, 2003], 'C.,': [1436, 1539, 1620, 1706, 2004], 'Li,': [1437, 1540, 1621, 1707, 2005], 'F.': [1438, 1541, 1622, 1708, 2006, 2165, 4124], 'Tomaselli': [1439, 1542, 1623, 1709, 2007, 4125], 'K.J.': [1440, 1543, 1624, 1710, 2008, 4126], 'Debatin': [1441, 1544, 1625, 1711, 2009], 'K.M.': [1442, 1545, 1626, 1712, 2010], 'Krammer': [1443, 1546, 1627, 1713, 2011], 'P.H.': [1444, 1547, 1628, 1714, 2012], 'Peter': [1445, 1548, 1629, 1715, 2013], 'M.E.': [1446, 1549, 1630, 1716, 2014], 'EMBO': [1447, 1550, 1631, 1717, 2015], '17:': [1450, 1553, 1634, 1720, 2018], '1675-1687Crossref': [1451, 1554, 1635, 1721, 2019], '(2631)': [1454, 1557, 1638, 1724, 2022], '23Budihardjo': [1457, 1560, 1641, 1727], 'Oliver': [1459, 1562, 1643, 1729, 2051], 'Lutter': [1461, 1564, 1645, 1731, 2053], 'Luo': [1463, 1566, 1647, 1733, 2055], 'X.': [1464, 1466, 1567, 1569, 1648, 1650, 1734, 1736, 2056, 2058], 'Wang': [1465, 1568, 1649, 1735, 2057, 4121], 'Cell': [1469, 1572, 1653, 1739, 2061, 3939], 'Dev.': [1470, 1573, 1654, 1740, 2062], '269-290Crossref': [1474, 1577, 1658, 1744, 2066], '(2269)': [1477, 1580, 1661, 1747, 2069], 'One': [1480, 2095], 'triggered': [1482], '"death': [1484], 'domain"': [1485], 'receptors,': [1486, 1495], 'tumor': [1490, 2085], 'factor': [1492, 2087], 'family': [1493], 'involves': [1497, 1670], 'formation': [1499, 1992], '"death-inducing': [1502], 'complex"': [1504], 'leading': [1505, 2300], 'initiator': [1509, 4085], 'caspases,': [1510], 'i.e.caspase-8': [1511], 'Initiator': [1583], 'then': [1585, 1940, 3094, 3411, 3442, 3559, 3580, 3878], 'activate': [1587, 1924, 2030, 2042], 'effector': [1588, 1784, 4082], 'caspase-3': [1592, 2026, 4083, 4162], 'second': [1665], 'pathway': [1667, 1927, 2195], 'alterations,': [1672], 'release': [1676, 1769, 1788, 1944, 2048, 2989, 3039], 'cytochrome': [1678, 1942, 2046], 'c(21Wolf': [1679], '24Kroemer': [1750], 'Dallaporta': [1752, 1809, 1885], 'Resche-Rigon': [1754, 1811, 1887], '60:': [1760, 1817, 1893], '619-642Crossref': [1761, 1818, 1894], '(1762)': [1764, 1821, 1897], 'Cytochrome': [1767, 1786], 'into': [1770, 2992, 3964], 'cytosol': [1772], 'necessary': [1774], 'caspase-9,': [1778], 'which,': [1779], 'activates': [1782, 2228], 'caspases.': [1785, 1919], 'may': [1789, 2040, 2395], 'opening': [1793], '(PTP),': [1800], 'although': [1801], 'issue': [1803], 'much': [1805], 'debated': [1806], '(24Kroemer': [1807, 1883], '25Crompton': [1824, 1900], 'Biochem.': [1826, 1902, 2896, 3690], '341:': [1829, 1905], '233-249Crossref': [1830, 1906], '(2114)': [1833, 1909], '26Martinou': [1836], 'J.C.': [1837], 'Nat.': [1840, 1857], 'Mol.': [1842, 1859], 'Cell.': [1843, 1860, 1955], '2:': [1846, 1863], '63-67Crossref': [1847], '(848)': [1850], '27Zamzami': [1853], 'Kroemer': [1855], '67-71Crossref': [1864], '(896)': [1867], 'Another': [1870], 'loss': [1876, 4101], 'transmembrane': [1880], 'potential,': [1881], 'ΔΨm': [1882, 3637], 'Mitochondrial': [1912, 3315, 3469], 'For': [1920, 3261], 'caspase-8': [1922, 1996, 2031, 2043, 2152, 4219, 4325], 'cleaving': [1929], 'Bid,': [1930], 'pro-apoptotic': [1932], 'member': [1933], 'Bcl-2': [1936], 'family,': [1938, 2088], 'mitochondria': [1946, 2155], '(28Li': [1947], 'Zhu': [1949], 'H.,': [1950], 'Xu,': [1951], 'C.J.': [1952], 'Yuan': [1953], '94:': [1957], '491-501Abstract': [1958], '(3789)': [1966], 'This': [1969], '"amplification"': [1970], 'pattern': [1971], 'thought': [1975], 'do': [1982], 'enough': [1986], 'level': [1987], 'death-inducing': [1989], 'complex': [1991], '(22Scaffidi': [1997], 'proteolytically': [2029], 'so': [2032], 'stimuli': [2034], 'subsequently': [2041], 'downstream': [2044], '(23Budihardjo': [2049], 'Little': [2072], 'known': [2074], 'about': [2075], 'receptors': [2082, 2208], 'unrelated': [2083], 'G': [2092, 2206], 'protein-coupled': [2093, 2207], 'receptors.': [2094], 'exception': [2096], 'somatostatin,': [2098], 'whose': [2099], 'receptor': [2100, 2213], 'coupled': [2102, 2220], 'pertussis': [2104, 2223], 'toxin-sensitive': [2105], 'Go/iprotein': [2106], '(29Reisine': [2107], 'Woulfe': [2109], 'Raynor': [2111], 'Kong': [2113], 'Heerding': [2115], 'Hines': [2117], 'Tallent': [2119], 'Law': [2121], 'CIBA': [2123], 'Found.': [2124], 'Symp.': [2125], '160-167PubMed': [2128], 'Somatostatin': [2131], 'recently': [2133], 'shown': [2134], 'stimulate': [2136], 'breast': [2139], 'cancer': [2140], 'recruiting': [2143], 'nonmembrane': [2145], 'tyrosine': [2146], 'phosphatase,': [2147], 'resulting': [2148], 'independent': [2153], '(30Liu': [2156], 'Martino': [2158], 'Thangaraju': [2160], 'Sharma': [2162], 'Halwani': [2164], 'Shen': [2166], 'S-H.': [2167], 'Patel': [2168], 'Y.C.': [2169], 'Srikant': [2170], 'C.B.': [2171], '9244-9250Abstract': [2177], '(106)': [2185], 'clear': [2191], 'apoptotic': [2194], 'activated': [2196], 'somatostatin': [2198], 'unique': [2200], 'utilized': [2203], 'well.': [2210], 'CCK-A': [2212], 'rodent': [2215], 'toxin-insensitive': [2224], 'Gq': [2225], 'phospholipase': [2229], 'report': [2279], 'depolarization,': [2299], 'caspase(s).': [2310], 'PTP-dependent': [2317], 'PTP-independent': [2319], 'addition': [2322, 3584], 'apoptosis,': [2324], 'processes': [2329], 'play': [2336, 2396], 'key': [2337], 'roles': [2338], 'trypsin.': [2352], 'Caspase-mediated': [2353], 'protection': [2354], 'These': [2392], 'role': [2399], 'Dispersed': [2408], 'were': [2412, 2503, 2525, 2554, 2589, 2717, 2785, 2816, 2840, 2908, 2965, 2979, 3058, 3093, 3142, 3158, 3170, 3200, 3223, 3228, 3319, 3346, 3403, 3425, 3461, 3530, 3558, 3702, 3727, 3822, 3877, 4004, 4014, 4022, 4035, 4048, 4068, 4184, 4295], 'prepared': [2413], 'using': [2414, 3146, 3162, 3301, 3599, 3704, 3780, 3921, 3993], 'previously': [2416, 2559, 2937, 3323, 3477, 3654, 3805, 3930], 'published': [2417], 'collagenase': [2418], 'digestion': [2419], 'method': [2420, 2891], '(12Gukovskaya': [2421, 2560, 2756, 2938, 2995], '31Pandol': [2483], 'Jensen': [2485], '1982;': [2492], '257:': [2493], '12024-12029Abstract': [2494], 'Isolated': [2501], 'washed': [2504, 3120, 3172, 3347, 3571, 3879], 'resuspended': [2506, 2661, 2710, 3178, 3356, 3884], '199': [2508], 'medium': [2509, 2994, 3967], 'supplemented': [2510], 'penicillin': [2512], '(100': [2513], 'units/ml),': [2514], 'streptomycin': [2515], '(0.1': [2516], 'mg/ml),': [2517], '0.5%': [2519, 3190], 'bovine': [2520, 3746, 3867], 'serum': [2521, 3747, 3868], 'albumin.': [2522], 'plated': [2526, 2913], 'at': [2527, 2540, 2619, 2642, 2649, 2655, 2682, 2694, 2825, 2844, 2874, 2924, 3208, 3216, 3231, 3289, 3294, 3429, 3436, 3447, 3606, 3611, 3769, 3774, 3827, 3893, 3906, 3913, 4227, 4281, 4397], 'concentration': [2529, 4151], '5': [2531, 3714, 3846], '×': [2532, 2827, 3218, 3431, 3449], '105/ml': [2533], '25-ml': [2535], 'tissue-culture': [2536], 'flasks': [2537], 'incubated': [2539, 2618, 2842, 3095, 3127, 3404, 3823], '37': [2541, 3232, 3828, 3894], '°C': [2542, 2621, 2846, 2876, 3210, 3233, 3829, 3895], '5%': [2545, 3081], 'CO2': [2546], 'humidified': [2547], 'atmosphere.': [2548], 'DNA': [2549, 2627, 2715, 2748, 2814, 2832, 2839, 2862], 'extraction': [2550, 2632, 3359], 'gel': [2552, 2723], 'electrophoresis': [2553], 'performed': [2555, 2751], 'we': [2557, 2753, 2935, 3803], 'described': [2558, 2754, 2936, 3322, 3476, 3653, 3804, 3929], 'Briefly,': [2585, 2781, 3699, 3818], 'collected': [2590, 2646, 2786, 3462, 3560], 'centrifugation,': [2592, 3562], 'lysed': [2593, 3412, 3581], 'buffer': [2596, 2664, 2732, 2794, 2853, 3104, 3181, 3236, 3360, 3712, 3732, 3836, 3983], 'containing': [2597, 2724, 2795, 2830, 2835, 2974, 3105, 3237, 3361, 3713, 3837], '10': [2598, 2603, 2606, 2796, 2801, 2920, 3247, 3370, 3434, 3626, 3855, 3858, 3862, 3981], 'mm': [2599, 2604, 2607, 2666, 2671, 2736, 2740, 2744, 2797, 2802, 3183, 3186, 3195, 3239, 3248, 3363, 3366, 3371, 3374, 3379, 3384, 3715, 3720, 3734, 3739, 3742, 3839, 3844, 3847, 3850, 3853, 3856, 3859, 3863], 'Tris-HCl': [2600, 3187], '(pH': [2601, 2799, 3089, 3188, 3241, 3353, 3368, 3717, 3841, 3984], '8.0),': [2602], 'NaCl,': [2605, 3184, 3740, 3845], 'EDTA,': [2608, 2803, 3380], '300': [2609], 'μg/ml': [2610, 2726, 2931, 3392], 'proteinase': [2611, 2690], 'K,': [2612], '1%': [2614, 3106], '(w/v)': [2615, 2806, 3082, 3107], 'SDS,': [2616], '48': [2620, 2695], 'until': [2622], 'mixture': [2624, 2699, 3390], 'became': [2625], 'clear.': [2626], 'purified': [2629, 3785], 'phenol/chloroform': [2631, 2703], '(1:1,': [2633], 'v/v),': [2634], 'precipitated': [2635, 2706], 'overnight': [2636, 2687, 2843], '0.3': [2638], 'm': [2639, 2885], 'sodium': [2640, 3860], 'acetate': [2641], '−20': [2643, 2925], '°C,': [2644, 2926], 'centrifugation': [2648, 2788, 3428, 3882], '15,000': [2650, 3217], '×g': [2651], '15': [2653, 2823, 3214], 'min': [2654, 2824, 2879, 2921, 3204, 3215, 3407, 3435, 3553, 3624, 3826, 4209], '4': [2656, 2845, 3209, 3437], '°C.': [2657, 2696, 3438], 'pellet': [2659, 3454, 3569, 3578], 'TE': [2663, 2712, 2792, 2851], '(10': [2665], 'Tris-HCl,': [2667, 3735], 'pH': [2668, 3736], '8.0,': [2669, 3737], '1': [2670, 2848, 2881, 3073, 3129, 3373, 3378, 3381, 3383, 3445, 3533, 3586, 3719, 3741, 3849, 3852, 4158, 4177, 4213, 4233, 4303, 4353], 'EDTA)': [2672], 'RNase': [2676], '(200': [2677, 2692], 'μg/ml)': [2678, 2693], '2': [2680, 2743, 3097, 3376], 'h': [2681, 3074, 3098, 3130, 3446], 'room': [2683], 'temperature,': [2684], 'followed': [2685], 'incubation': [2688, 2993, 3076, 4174, 4211, 4394], 'K': [2691], 'Finally,': [2697], 're-extracted': [2701], 'chloroform,': [2705], 'ethanol,': [2708], 'buffer.': [2713, 3139, 3888], 'fragments': [2716], 'electrophoretically': [2718, 3063], 'separated': [2719, 2817, 3059], '1.8%': [2721], 'agarose': [2722], '0.5': [2725, 2884, 3194], 'ethidium': [2727], 'bromide': [2728], '0.5×': [2730], 'TBE': [2731], '(1-': [2733], 'TBE:': [2734], '89': [2735, 2739], 'Tris': [2737, 2798], 'base,': [2738], 'boric': [2741], 'acid,': [2742, 3865], 'EDTA).': [2745], 'Quantification': [2746], 'fragmentation': [2749], 'before': [2755], 'suspended': [2790, 2909], 'lysis': [2793, 2852, 3180], '7.5),': [2800, 3189, 3242], '0.2%': [2805], 'Triton': [2807, 3054], 'X-100.': [2808, 3055], 'High': [2809], 'low': [2811], 'molecular': [2812, 2837], 'weight': [2813, 2838], 'molecules': [2815], 'centrifuging': [2819], 'samples': [2821], '13,000': [2826], 'g.': [2828], 'Supernatants': [2829], 'fragmented': [2831, 2977], 'pellets': [2834, 2869], 'each': [2841, 3393, 4398], 'ml': [2849, 2856, 2882, 3587], '0.25': [2855], '50%': [2858], '(v/v)': [2859, 3114], 'trichloroacetic': [2860], 'acid.': [2861], 'precipitates': [2864], 'supernatants': [2867, 3222], 'hydrolyzed': [2871], 'heating': [2873], '70': [2875], '20–25': [2878], 'HClO4and': [2886], 'quantified': [2887, 3159], 'diphenylamine': [2890], 'Burton': [2893], '(32Burton': [2894], '1956;': [2898], '62:': [2899], '315-322Crossref': [2900], '(10844)': [2903], 'phosphate-buffered': [2911, 3175, 3351, 3575], 'saline,': [2912, 3176], 'polylysine-coated': [2915], 'glass': [2916, 3415, 3706], 'coverslips,': [2917], 'fixed': [2918], 'methanol': [2923], 'stained': [2928], '8': [2930], 'Hoechst': [2932], '33258': [2933], 'slides': [2964], 'examined': [2966], 'fluorescence': [2968, 3298, 3768, 3795, 3899], 'microscopy.': [2969], 'nuclei': [2973, 3424], 'condensed': [2975], 'and/or': [2976], 'chromatin': [2978], 'apoptotic.': [2981], 'Acinar': [2982], 'determined': [2986, 3049, 3474, 3598, 3779, 3973], 'LDH': [2991, 3020, 3038, 3048], 'activity': [3021, 3642], 'measured': [3023, 3644, 3892, 3919], 'spectrofluorimetrically': [3024], 'production': [3027], 'NAD': [3029], 'pyruvic': [3031], 'NADH.': [3034], 'values': [3036, 3950, 3999], 'presented': [3041], 'percentages': [3044], 'total': [3046, 3970], 'cellular': [3047, 3971], 'permeabilizing': [3051, 3975], 'proteins': [3057], 'SDS-PAGE': [3061], 'transferred': [3064], 'nitrocellulose': [3066], 'membranes.': [3067], 'Nonspecific': [3068], 'binding': [3069], 'blocked': [3071], 'membranes': [3079], 'nonfat': [3083, 3108], 'dry': [3084, 3109], 'milk': [3085, 3110], 'Tris-buffered': [3087, 3118], 'saline': [3088, 3352], '7.5).': [3090], 'blots': [3092, 3141], 'primary': [3100], 'antibodies': [3101], 'antibody': [3103, 3135, 3138], 'TTBS': [3112], '(0.05%': [3113], 'Tween': [3115], '20': [3116, 3256, 3365, 3838], 'saline),': [3119], 'three': [3121], 'times': [3122, 4194, 4283], 'TTBS,': [3124], 'finally': [3126], 'peroxidase-labeled': [3133], 'secondary': [3134], 'developed': [3143], 'visualization': [3145], 'enhanced': [3147], 'chemiluminescence': [3148], 'detection': [3149], 'kit': [3150, 3924], '(Pierce).': [3151], 'band': [3153], 'intensities': [3154, 4274], 'immunoblots': [3157], 'densitometry': [3161], 'Scion': [3163], 'Image': [3164], 'software': [3165], '(Scion': [3166], 'Corporation).': [3167], 'collected,': [3171], 'ice-cold': [3174, 3350, 3574, 3711], 'containing150': [3182], '50': [3185], 'Nonidet': [3191], 'P-40,': [3192], 'EDTA.': [3196], 'lysates': [3199], 'placed': [3201], '30': [3203, 3406, 3552, 3623, 3825, 4208], 'rotator': [3207], 'centrifuged': [3212, 3443], 'g,': [3219, 3450], 'collected.': [3224], 'proteolytic': [3226], 'reactions': [3227], 'carried': [3229], 'out': [3230], '25': [3238], 'HEPES': [3240, 3840], '10%': [3243], 'sucrose,': [3244, 3364], '0.1%': [3245, 3866, 3978], 'CHAPS,': [3246], 'dithiothreitol,': [3249], '800': [3250], 'μg': [3251], 'cytosolic': [3253, 3317], 'protein,': [3254], 'μm': [3257, 3534, 3627, 3832], 'fluorogenic': [3259], 'substrate.': [3260], 'caspase-3,': [3262], 'substrate': [3264, 3271, 3279], 'Ac-Asp-Glu-Val-Asp-AMC': [3266], '(AnaSpec);': [3267], 'caspase-8,': [3269], 'Ac-Ile-Glu-Thr-Asp-AMC': [3273], '(AnaSpec).': [3274], 'Cleavage': [3275], 'relieves': [3280], 'AMC,': [3281], 'emits': [3283, 3767], 'fluorescent': [3285, 3763], 'signal': [3286], 'excitation': [3288, 3605, 3773, 3905], '380': [3290, 3775, 3909], 'nm': [3291, 3608, 3771, 3910, 4156], 'emission': [3293, 3610, 3912], '440': [3295, 3770], 'nm.': [3296, 3613, 3776, 3915], 'calibrated': [3300], 'standard': [3303, 3782], 'curve': [3304, 3783], 'AMC.': [3306], 'data': [3308, 3990], 'expressed': [3310, 3955], 'mol': [3312], 'AMC/mg': [3313], 'protein/min.': [3314], 'fractions': [3318], 'obtained': [3320], '(33Bossy-Wetzel': [3324], 'E.': [3325], '17484-17490Abstract': [3333], '(286)': [3341], 'twice': [3348, 3572, 3880], '7.2)': [3354], '250': [3362, 3723], 'HEPES-KOH': [3367], '7.0),': [3369], 'KCl,': [3372, 3848], 'EGTA,': [3375], 'mmMgCl2,': [3377], 'mmdithiothreitol,': [3382], 'phenylmethylsulfonyl': [3385], 'fluoride,': [3386], 'protease': [3388], 'inhibitor': [3389], '(5': [3391], 'pepstatin,': [3395], 'leupeptin,': [3396], 'chymostatin,': [3397], 'antipain,': [3398], 'aprotinin).': [3400], 'ice': [3409], 'Dounce': [3416], 'homogenizer': [3417, 3708], '(80': [3418], 'strokes': [3419], 'B': [3421], 'pestle).': [3422], 'removed': [3426], '1000': [3430], 'g': [3432], 'supernatant': [3440, 3458, 3564], '100,000': [3448], 'fraction)': [3456, 3460], '(cytosolic': [3459], 'separately': [3463], 'Western': [3467, 4071, 4215], 'blotting.': [3468], 'membrane': [3470], 'potential': [3471], '(ΔΨm)': [3472], '(34Pastorino': [3478], 'J.G.': [3479], 'Chen': [3480], 'S.-T.': [3481], 'Tafani': [3482], 'Snyder': [3484], 'J.W.': [3485], 'Farber': [3486], '273:': [3492], '7770-7775Abstract': [3493], '(534)': [3501], 'measuring': [3505], 'retention': [3507], 'dye': [3510], '(DiOC6)': [3512], '(3Williams': [3513, 3536], '(Molecular': [3526], 'Probes).': [3527], 'loaded': [3531, 3799], 'DiOC6': [3535], 'during': [3549], 'last': [3551], 'treatment.': [3555], 'removed,': [3566], 'saline.': [3576], 'H2O.': [3589], 'amount': [3591, 3615, 3960], 'DiOC6(3)': [3593, 3617], 'retained': [3594, 3618], 'Shimadzu': [3601, 3901], 'RF-1501': [3602, 3902], 'spectrofluorimeter': [3603, 3903], '488': [3607], '500': [3612], 'pretreated': [3621], 'CCCP': [3628], '(a': [3629], 'protonophore)': [3630], 'correspond': [3634], 'value': [3638], '0.': [3640], 'Trypsin': [3641, 3777], 'homogenates': [3647, 3726], 'fluorimetric': [3650], 'assay': [3651, 3731, 4061], '35Kawabata': [3674], 'Miura': [3676], 'Morita': [3678], 'Kato': [3680], 'Fujikawa': [3682], 'Takada': [3684], 'Sakakbara': [3686], 'Eur.': [3688], '1988;': [3691], '172:': [3692], '17-25Crossref': [3693], '(234)': [3696], 'homogenized': [3703], 'Teflon': [3707], 'MES': [3716], '6.5),': [3718], 'MgSO4,': [3721], 'mmsucrose.': [3724], 'mixed': [3728], '(50': [3733], '150': [3738], 'CaCl2,': [3743, 3854], '0.1': [3744, 4153], 'mg/ml': [3745], 'albumin)': [3748], 'substrate,': [3752], 'Boc-Gln-Ala-Arg-AMC': [3753], '(Peptide': [3754], 'International),': [3755], 'converted': [3758], 'product.': [3764, 4319], 'product': [3766, 4342], '(Worthington)': [3787], '[Ca2+]': [3788, 3889], 'i': [3789, 3890], 'monitored': [3791], 'changes': [3793, 4290], 'intensity': [3796], 'Fura-2,': [3801], '(36Gukovskaya': [3806], '266:': [3814], 'G350-G356PubMed': [3815], '3': [3831], 'Fura-2AM': [3833, 4053], '7.4),': [3842], '120': [3843], 'MgCl2,': [3851], 'glucose,': [3857], 'pyruvate,': [3861], 'ascorbic': [3864], 'albumin,': [3869], '0.01%': [3871], 'soybean': [3872], 'inhibitor.': [3874], 'same': [3887], 'monitoring': [3897], 'Fura-2': [3898], '340': [3907], '510': [3914], 'Amylase': [3916], 'spectrophotometrically': [3920], 'Phadeba': [3922], 'amylase': [3923, 3952, 3962, 3972], 'Pharmacia': [3926], 'Diagnostics': [3927], '(37Pandol': [3931], 'Rodriguez': [3933], 'Muallem': [3935], 'Mendius': [3937], 'K.E.': [3938], 'Calcium.': [3940], '255-262Crossref': [3943], '(6)': [3946], 'ratios': [3957], 'released': [3963], 'extracellular': [3966], 'SDS': [3979], 'mmphosphate': [3982], '7.8).': [3985], 'Statistical': [3986], 'analysis': [3987, 4073, 4217], 'done': [3992], 'unpaired': [3994], "Student's": [3995], 't': [3996], 'test.': [3997], 'p': [4001], '<': [4002], '0.05': [4003], 'statistically': [4006], 'significant.': [4007], 'Antibodies': [4008], 'caspases-3,': [4010], '-8,': [4011], '-9': [4013, 4088], 'Santa': [4016], 'Cruz': [4017], 'Biotechnology;': [4018], 'those': [4019], 'Pharmingen.': [4024], 'CCK-8': [4025, 4076, 4150, 4196, 4271], 'Peninsula': [4028], 'Laboratories.': [4029, 4065], 'inhibitors': [4031], 'zVAD-fmk': [4032], 'zIETD-fmk': [4034], 'Enzyme': [4037], 'Systems': [4038], 'Products': [4039], 'Calbiochem,': [4041], 'respectively;': [4042], 'Biomol': [4050], 'Research': [4051], 'Laboratories;': [4052], 'Molecular': [4056], 'Probes;': [4057], 'Bio-Rad': [4059, 4064], 'Other': [4066], 'reagents': [4067], 'Sigma.': [4070], 'blot': [4072, 4216], 'showed': [4074], 'caspases-8': [4086], '(Fig.1).': [4095], 'Caspase-3': [4096, 4146], 'recognized': [4099, 4327], '32-kDa': [4104], 'pro-form': [4105, 4362], 'accumulation': [4107, 4315], '17-kDa': [4110], 'form': [4112], '(38Fernandes-Alnemri': [4113], 'Armstrong': [4115], 'R.C.': [4116], 'Krebs': [4117], 'Srinivasula': [4119], 'S.M.': [4120], 'Bullrich': [4123], 'Litwack': [4127], 'Alnemri': [4129], 'E.S.': [4130], 'Proc.': [4131], 'Natl.': [4132], 'Acad.': [4133], 'U.': [4135], '93:': [4139], '7464-7469Crossref': [4140], '(693)': [4143], 'processing': [4147, 4323, 4358], 'increased': [4148, 4172, 4392], '100': [4155], '(Fig.': [4157, 4176, 4212, 4232, 4302, 4352], 'A).': [4159], 'Processing': [4160], 'detected': [4165, 4185, 4224, 4356], 'time': [4175, 4395, 4399], 'B).': [4178, 4214, 4304, 4344], 'no': [4181], 'normal': [4187], 'tissue': [4189], '(not': [4190], 'shown).': [4191], 'At': [4192], 'all': [4193, 4282], 'studied,': [4195, 4284], 'further': [4197], 'cleavage': [4199, 4306], 'procaspase-3,': [4201], 'effect': [4203], 'being': [4204], 'already': [4205], 'manifested': [4206], 'after': [4207], 'doublet': [4226], '∼50': [4228], '54': [4230], 'kDa': [4231], 'B)': [4234, 4354], 'possibly': [4235], 'corresponding': [4236], 'caspases-8a': [4238], '-8b': [4240], '(39Sun': [4241, 4363], 'X.M.': [4242, 4364], 'MacFarlane': [4243, 4365], 'Zhuang': [4245, 4367], 'Wolf': [4247, 4369], 'Cohen': [4251, 4373], 'G.M.': [4252, 4374], '5053-5060Abstract': [4258, 4380], '(780)': [4266, 4388], 'Stimulation': [4269], 'decreased': [4272], 'p54': [4277, 4293, 4308], 'p50': [4279, 4301, 4310], 'bands': [4280], 'compared': [4285], 'isoform': [4294, 4335], 'usually': [4296], 'more': [4297], 'pronounced': [4298], 'than': [4299], 'associated': [4312], '∼45-kDa': [4318], 'time-dependent': [4330], 'decrease': [4331], '54-kDa': [4334], 'concomitant': [4337], 'increase': [4338], 'p45': [4341], '(Fig.1': [4343], 'Activation': [4345], 'caspase-9': [4347], '∼48-kDa': [4361], 'point': [4400]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2050332606', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 7}, {'year': 2013, 'cited_by_count': 6}, {'year': 2012, 'cited_by_count': 8}], 'updated_date': '2024-12-15T00:22:31.046344', 'created_date': '2016-06-24'}
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