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750, 773, 793, 795, 823, 837, 860, 862, 945, 1036, 1065, 1123, 1151, 1154, 1174, 1179, 1199, 1207, 1238, 1251, 1254, 1286, 1302, 1317, 1326, 1354, 1375, 1439, 1447, 1471, 1526, 1578, 1588, 1670, 1695, 1704, 1720, 1738, 1768, 1802, 1858, 1862, 1875, 1888, 1908, 1921, 1927, 1936, 1951, 1963, 1978, 1982, 1987, 2009, 2028, 2045, 2055, 2058, 2068, 2090, 2096, 2110, 2132, 2161, 2177, 2185, 2193, 2202, 2212, 2252, 2341, 2351, 2371, 2406, 2423, 2447, 2502, 2636, 2776, 2809, 2833, 2857, 2894, 2914, 2925, 2945, 2996, 3035, 3045, 3051, 3079, 3116, 3118, 3125, 3133, 3138, 3154, 3193, 3214, 3281, 3319, 3399, 3424, 3550, 3600, 3604, 3712, 3732, 3753, 3853, 3880, 3909, 4041, 4058, 4065, 4094, 4100, 4133], 'mammary': [17, 540, 2908, 2916, 2923], 'tumors': [18, 507, 569, 583, 1257, 1837, 1904, 1914, 1944, 2040, 2050, 2076, 2234, 2327, 2464, 2662, 3050, 3054, 3155], 'Robert': [19, 25, 199, 205], 'A.': [20, 26, 200, 206], 'Soslow': [21, 27, 201, 207], 'M.D.,': [22, 70, 103, 202, 250, 283], 'Corresponding': [23, 203], 'Author': [24, 204], 'M.D.': [28, 74, 106, 208, 254, 286], '[email protected]': [29, 209], 'Department': [30, 52, 75, 107, 210, 232, 255, 287], 'of': [31, 39, 53, 76, 84, 108, 116, 211, 219, 233, 256, 264, 288, 296, 406, 416, 429, 440, 465, 476, 486, 508, 547, 560, 567, 576, 581, 677, 717, 734, 765, 776, 820, 839, 850, 855, 874, 963, 972, 1020, 1052, 1104, 1164, 1244, 1266, 1276, 1406, 1409, 1544, 1573, 1631, 1634, 1642, 1658, 1681, 1716, 1754, 1794, 1799, 1804, 1806, 1817, 1839, 1894, 1992, 2078, 2117, 2138, 2231, 2452, 2483, 2490, 2493, 2497, 2510, 2548, 2597, 2632, 2646, 2669, 2715, 2742, 2773, 2789, 2806, 2849, 2921, 2930, 2936, 2943, 2975, 2981, 3004, 3112, 3129, 3135, 3142, 3151, 3179, 3202, 3206, 3210, 3223, 3256, 3263, 3279, 3304, 3312, 3341, 3366, 3426, 3435, 3464, 3467, 3483, 3489, 3529, 3543, 3577, 3719, 3781, 3788, 3798, 3817, 3833, 3837, 3843, 3870, 3876, 3888, 3894, 3913, 3917, 3928, 3932, 3944, 3975, 4007, 4018, 4034, 4043, 4081, 4087, 4097, 4102, 4116], 'Pathology,': [32, 54, 109, 212, 234, 289], 'New': [33, 42, 44, 58, 78, 92, 94, 110, 119, 121, 213, 222, 224, 238, 258, 272, 274, 290, 299, 301, 1165], 'York': [34, 45, 56, 79, 111, 214, 225, 236, 259, 291, 1166], 'Presbyterian': [35, 80, 112, 215, 260, 292, 1167], 'Hospital-Weill': [36, 81, 113, 216, 261, 293], 'Medical': [37, 82, 114, 217, 262, 294], 'College': [38, 83, 115, 218, 263, 295], 'Cornell': [40, 85, 117, 220, 265, 297], 'University,': [41, 118, 221, 298], 'York,': [43, 59, 93, 120, 223, 239, 273, 300], 'fax:': [46, 226], '(212)': [47, 227], '717-3203Memorial': [48, 228], 'Sloan-Kettering': [49, 229], 'Cancer': [50, 89, 230, 269, 707, 712], 'Center,': [51, 91, 231, 271], '1275': [55, 235], 'Avenue,': [57, 237], 'NY': [60, 240], '10021===Search': [61, 241], 'for': [62, 96, 123, 141, 159, 175, 193, 242, 276, 303, 321, 339, 355, 373, 762, 817, 1186, 1221, 1319, 1394, 1503, 1511, 3499], 'more': [63, 97, 124, 142, 160, 176, 194, 243, 277, 304, 322, 340, 356, 374, 635, 3582], 'papers': [64, 98, 125, 143, 161, 177, 195, 244, 278, 305, 323, 341, 357, 375], 'by': [65, 99, 126, 144, 162, 178, 196, 245, 279, 306, 324, 342, 358, 376, 516, 700, 747, 778, 785, 808, 1258, 1490, 1505, 1537, 1627, 1734, 2738, 3170, 3220, 3403, 3453, 3512, 3570, 3608, 3663, 3703, 3745, 3767, 3776, 3967, 3991, 4025], 'this': [66, 100, 127, 145, 163, 179, 197, 246, 280, 307, 325, 343, 359, 377, 441, 981, 1111, 1609, 2694, 2735, 3478, 3799, 3984], 'authorAndrew': [67, 247], 'J.': [68, 72, 167, 248, 252, 347], 'Dannenberg': [69, 73, 249, 253], 'Andrew': [71, 251], 'Medicine,': [77, 257], 'University': [86, 266], 'Strang': [88, 268], 'Prevention': [90, 270], 'YorkSearch': [95, 122, 275, 302], 'authorDemaretta': [101, 281], 'Rush': [102, 105, 282, 285], 'Demaretta': [104, 284], 'authorB.': [128, 308], 'M.': [129, 133, 309, 313], 'Woerner': [130, 134, 310, 314], 'M.S.,': [131, 311], 'B.': [132, 312, 2724], 'M.S.': [135, 315], 'Pharmacia': [136, 154, 170, 188, 316, 334, 350, 368], 'Corporation,': [137, 155, 171, 189, 317, 335, 351, 369], 'St.': [138, 156, 172, 190, 318, 336, 352, 370], 'Louis,': [139, 157, 173, 191, 319, 337, 353, 371], 'MissouriSearch': [140, 158, 174, 192, 320, 338, 354, 372], 'authorK.': [146, 326], 'Nasir': [147, 151, 327, 331], 'Khan': [148, 152, 328, 332], 'D.V.M.,': [149, 329], 'K.': [150, 330], 'D.V.M.': [153, 333], 'authorJ.': [164, 344], 'Masferrer': [165, 168, 345, 348, 1569], 'Ph.D.,': [166, 183, 346, 363], 'Ph.D.': [169, 187, 349, 367], 'authorAlane': [180, 360], 'T.': [181, 185, 361, 365], 'Koki': [182, 186, 362, 366, 1565], 'Alane': [184, 364], 'author': [198, 378], 'First': [379], 'published:': [380], '20': [381, 506], 'December': [382], '2000': [383, 710], 'https://doi.org/10.1002/1097-0142(20001215)89:12<2637::AID-CNCR17>3.0.CO;2-BCitations:': [384], '598': [385], 'AboutSectionsPDF': [386], 'ToolsRequest': [387], 'permissionExport': [388], 'citationAdd': [389], 'to': [390, 412, 435, 480, 492, 596, 637, 660, 686, 799, 922, 995, 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1529, 1539, 1542, 1591, 1605, 1632, 1643, 1714, 1717, 1732, 1736, 1743, 1777, 1792, 1821, 1830, 1840, 1869, 1895, 1937, 1993, 2069, 2079, 2118, 2139, 2213, 2453, 2494, 2499, 2549, 2561, 2633, 2670, 2743, 2774, 2790, 2800, 2807, 2827, 2946, 3011, 3025, 3113, 3130, 3136, 3152, 3177, 3203, 3211, 3221, 3247, 3261, 3275, 3324, 3330, 3342, 3345, 3356, 3378, 3436, 3481, 3560, 3574, 3685, 3695, 3779, 3789, 3796, 3812, 3823, 3834, 3867, 3885, 3929, 3942, 3973, 4004, 4012, 4016, 4035, 4038, 4044, 4088, 4098, 4103, 4114], 'Wiley': [423], 'Online': [424], 'Library': [425], 'UseShareable': [430], 'LinkUse': [431], 'link': [433], 'a': [437, 452, 594, 907, 967, 986, 1097, 1116, 1679, 1865, 2325, 2385, 2573, 2590, 2748, 2821, 2874, 2952, 3180, 3282, 3297, 3442, 3840, 3873, 3976, 4109, 4117, 4141], 'article': [442], 'with': [443, 621, 925, 975, 1073, 1401, 1419, 1449, 1492, 1513, 1528, 1562, 1639, 1685, 1998, 2005, 2024, 2106, 2112, 2129, 2144, 2465, 2617, 2663, 2814, 3024, 3100, 3229, 3323, 3385, 3448, 3711, 4003, 4140], 'your': [444], 'friends': [445], 'colleagues.': [447], 'Learn': [448], 'more.Copy': [449], 'URL': [450], 'Share': [451], 'linkShare': [453], 'onFacebookTwitterLinked': [454], 'InRedditWechat': [455], 'Abstract': [456], 'BACKGROUND': [457], 'The': [458, 483, 498, 1022, 1172, 1263, 1335, 1363, 1623, 1726, 1930, 1945, 1955, 2017, 2062, 2206, 2346, 2641, 2984, 3030, 3254, 3317, 3334, 3611, 3682, 3749, 3915, 4070], 'cyclooxygenase': [459, 721], '(COX)': [460, 722], 'enzyme': [461], 'catalyzes': [462, 731], 'formation': [464, 1070], 'prostaglandins,': [466], 'which': [467, 599, 868, 1039, 1133, 1601, 1776, 3010, 3175, 3359, 3376, 3654, 3741, 3827], 'can': [468, 744, 782, 3554, 3773], 'affect': [469], 'cell': [470, 571, 1851, 1856, 2250, 2310, 2339, 2450, 2505, 2531, 3265, 3652, 3671, 3861, 4040], 'proliferation': [471], 'alter': [473], 'response': [475], 'immune': [478, 752, 4135], 'system': [479, 555], 'malignant': [481, 4118], 'cells.': [482, 2374, 2540, 3082], 'inducible': [484], 'form': [485], 'COX,': [487, 870], 'COX-2,': [488, 3269, 3280], 'has': [489, 796, 812, 1057, 1611, 3950, 3987], 'been': [490, 797, 1058, 1612, 3199, 3606, 3657, 3989], 'shown': [491, 798, 1059, 1613, 2223], 'be': [493, 687, 783, 832, 993, 1137, 1781, 3555, 3620, 3701, 3735, 3774, 3793, 4067], 'important': [494, 727, 3815, 4031], 'carcinogenesis.': [496, 729], 'METHODS': [497, 1144], 'authors': [499], 'studied': [500, 3884, 3905], 'COX-1': [501, 655, 684, 804, 1122, 1366, 1414, 3029, 3037, 3061, 3085, 3093, 3184], '-2': [503], 'expression': [504, 606, 624, 668, 781, 1125, 2354, 2399, 2414, 2459, 2542, 2657, 2726, 2783, 2836, 2861, 2888, 2904, 2990, 3006, 3021, 3062, 3086, 3094, 3141, 3241, 3420, 3444, 3485, 3546, 3584, 3616, 3693, 3725, 3783, 3836, 3857, 3869, 3887, 3920, 3958, 3996, 4076], 'lung,': [510, 679, 3114, 3137, 3212], 'colon,': [511, 680, 857, 3115, 3131, 3213, 4099], 'breast': [513, 582, 631, 682, 1152, 2080, 2866, 2875, 3046, 3117, 3252, 3845, 3859, 3878, 3897, 3933], '(60': [514, 1169], 'total)': [515], 'using': [517, 551, 1259, 1436, 1522, 1829, 3292], 'commercially': [518], 'available': [519, 1220], 'monoclonal': [520, 1367], 'polyclonal': [522, 1377], 'antibodies': [523], 'on': [524, 1604, 1678, 3714], 'formalin': [525, 1295], 'fixed,': [526, 1495], 'paraffin': [527, 1300, 1496], 'embedded': [528, 1298, 1497], 'tissue.': [529, 3195], 'Our': [530, 3409, 3592, 3707, 3831], 'evaluation': [531, 1798, 3289], 'also': [532, 830, 933, 1006, 1066, 1272, 2364, 3072, 3235, 3369, 3742, 3756], 'included': [533, 1948, 3377], 'seven': [534], 'carcinoma-associated': [535, 1203], 'colonic': [536, 644, 1063, 1946, 1965, 2565, 2638, 2700, 2719, 3730, 3790], 'adenomas': [537, 2004, 2832, 2838], '10': [539, 1912, 1971], 'ductal': [541, 587, 1208, 1267, 2093, 2099, 2314, 2321, 2895, 2909, 3015, 3243], 'carcinomas': [542, 572, 676, 1209, 1852, 1994, 2094, 2141, 2486, 2506, 2532, 2690, 2917, 2924, 2938, 2998, 3111, 3128, 3150, 3209, 3518, 3565, 3632, 3672, 3846, 3934], 'situ': [544, 1270, 2102, 2912, 3394], '(DCIS).': [545], 'Quantitation': [546], 'immunoreactivity': [548, 656, 702, 1533, 1703, 2240, 2333, 2647, 3038], 'was': [549, 600, 634, 657, 1219, 1273, 1534, 1724, 1756, 1761, 1765, 1770, 1933, 1940, 2033, 2060, 2065, 2072, 2197, 2200, 2204, 2209, 2216, 2349, 2355, 2365, 2415, 2543, 2784, 2905, 3033, 3039, 3063, 3073, 3087, 3144, 3160, 3290, 3480, 3743], 'accomplished': [550, 3291], 'an': [552, 814, 1001, 1138, 1420, 1597, 1629, 1640, 3891], 'immunohistochemical': [553, 1118, 1187, 1598, 3204, 3231, 3835, 3868, 3886], 'scoring': [554, 1621], 'that': [556, 720, 827, 883, 894, 1008, 1017, 1083, 2235, 2328, 2472, 2672, 2829, 2840, 2850, 3267, 3301, 3416, 3446, 3495, 3507, 3532, 3562, 3684, 3697, 3765, 3807, 3937], 'approximates': [557], 'use': [559, 1103, 3222], 'image': [561, 1619, 2736], 'analysis-based': [562, 1620], 'systems.': [563], 'RESULTS': [564, 2219], 'Ninety': [565, 2481], 'percent': [566, 1805, 2482, 2741, 2772, 2935], 'lung': [568, 1498, 2386, 2454, 4089], '(squamous': [570], 'adenocarcinomas),': [574], '71%': [575, 923], 'colon': [577, 628, 821, 2574, 2634, 2671, 3153, 3722], 'adenocarcinomas': [578, 1847, 2639], '56%': [580, 2920], '(DCIS': [584], 'infiltrating': [586, 2083, 2086, 2092, 2140, 2313, 2317, 2915, 2922, 2937, 2997, 3014], 'lobular': [589, 2087, 2318, 2892], 'carcinomas)': [590], 'at': [593, 690, 902, 1045, 1360, 2380, 2568, 2589, 2747, 2820, 2869, 2951, 3188, 3404], 'moderate': [595, 647, 661, 701, 2237, 2330, 2591, 2749, 2822], 'strong': [597, 1758, 2239, 2332, 2593, 2751, 2824, 3759], 'level,': [598], 'significantly': [601, 959, 3018], 'different': [602, 3571], 'from': [603, 736, 1159, 1232, 1294, 1564, 1618, 1747, 2384, 2572, 2708, 2873, 3055, 3173, 3344, 3509, 3939, 3970], 'negligible': [605], 'distant': [608, 1191, 2707, 3172, 3969], 'nonneoplastic': [609, 653, 705, 1192, 2599, 2609, 2699, 2705, 2718, 3042, 3101, 3163, 3194, 3271, 3785, 3818, 3960, 4013], 'epithelium': [610, 645, 2720, 3164, 3171, 3961, 3968], '(controls;': [611], 'P': [612, 1825], '<': [613], '0.0001).': [614], 'Poorly': [615], 'differentiated': [616, 675, 1874, 1886, 1891, 1960, 1973, 1989, 2554, 2558, 2778, 2792, 2796, 2802, 3013, 3127, 3149, 3491, 3650, 3661], 'histologic': [617, 3450, 3468, 3497, 3739], 'features': [618], 'were': [619, 1157, 1177, 1184, 1227, 1292, 1309, 1337, 1388, 1399, 1434, 1456, 1501, 1509, 1520, 1729, 1784, 1811, 1827, 1872, 1877, 1897, 1901, 1906, 1910, 1916, 1919, 1923, 1968, 1995, 2120, 2124, 2134, 2142, 2167, 2173, 2181, 2189, 3103, 3519], 'correlated': [620, 3737], 'low': [622, 691, 2148, 3026, 3189, 3305, 3575, 3874], 'overall,': [625], 'especially': [626], 'carcinomas.': [629, 642], 'Among': [630], 'carcinomas,': [632, 1857, 2834, 3653], 'DCIS': [633, 2295, 2926, 2986, 2995, 3908, 3922, 3945, 4101], 'likely': [636], 'express': [638, 2475, 2675, 2712, 3268, 3522], 'than': [640, 3587, 3764], 'invasive': [641, 2637, 3251, 4082], 'Adenomatous': [643], 'showed': [646, 1864, 2163, 2396, 2516, 2526, 2601, 2611, 2757, 2767, 2830, 2885, 2958, 2968, 2991, 3001, 3017, 3637, 3757], 'expression,': [649, 2605, 3761], 'as': [650, 1012, 1226, 1649, 1655, 1662, 1665, 1668, 1672, 1772, 3022, 3098, 3470, 3633, 3659, 3822, 4030], 'did': [651, 983, 2388, 2576, 2710, 2877, 3439, 3645, 3667], 'adjacent': [652, 704, 1215, 2442, 2598, 2608, 2688, 3048, 3165, 3429, 3962, 3997], 'epithelium.': [654, 706, 2896], 'essentially': [658, 806], 'weak': [659, 2362, 3070], 'all': [663, 1395, 2484, 2794, 3000, 3264], 'tissues': [664, 1500, 3047, 3097, 3102, 3398, 4014], 'evaluated.': [665], 'CONCLUSIONS': [666], 'upregulated': [670], 'well': [672, 1782, 1969, 1986, 2121, 2538, 2775, 3124, 3490], 'moderately': [674, 1873, 1885, 1898, 1972, 2125, 2518, 2553, 2557, 2602, 2759, 2777, 2791, 2960, 3012, 3126], 'whereas': [683, 2524, 2606, 2765, 2966], 'appears': [685, 3733], 'constitutively': [688, 757, 3186], 'levels.': [692], 'A': [693, 714, 2468, 2666], 'possible': [694, 3283], 'paracrine': [696, 3181, 3285], 'effect': [697], 'suggested': [699, 3744], '2000;89:2637–45.': [708], '©': [709], 'American': [711], 'Society.': [713], 'substantial': [715], 'body': [716], 'evidence': [718, 1007], 'indicates': [719, 826], 'prostaglandins': [724, 4023], '(PGs)': [725], 'are': [726, 1018, 1706, 2222, 2241, 2334, 3411, 3594, 3676, 3709, 4063], 'Cyclooxygenase': [730], 'synthesis': [733], 'PGs': [735], 'arachidonic': [737], 'acid.': [738], 'Several': [739, 878], 'PGs,': [740], 'most': [741, 1224, 1721, 2356, 2535, 2607, 3064, 3120], 'notably': [742, 3811], 'PGE2,': [743], 'promote': [745, 4131], 'tumorigenesis': [746, 854], 'stimulating': [748], 'angiogenesis': [749], 'inhibiting': [751, 1134], 'surveillance.1,': [753], '2': [754, 1692, 1854, 1876, 1922, 1928, 1952, 1975, 2046, 2056, 2156, 2382, 2570], 'COX-1,': [755], 'isoform,': [759], 'responsible': [761], 'cytoprotection': [764], 'gastric': [766], 'surface': [767], 'epithelium,': [768], 'vasodilatation': [769], 'kidney,': [772], 'production': [775], 'thromboxane': [777], 'platelets.3': [779], 'induced': [784], 'inflammatory': [786, 2373, 3081, 4049], 'mediators,': [787], 'cytokines,': [788], 'mitogens,': [789], 'growth': [790, 4057], 'factors,': [791], 'oncogenes,': [792], 'carcinogens': [794], 'inhibit': [800, 869, 1042, 1061, 1088], 'apoptosis.4-7': [801], 'In': [802, 1075, 2456, 2654, 2703, 2972, 3083], 'contrast,': [803, 1077, 2457, 2655, 2704, 2973], 'remains': [805], 'unaffected': [807], 'these': [809, 875, 1093, 2652, 3056, 3563, 4061], 'factors.8': [810], 'COX': [811, 828, 851, 1032, 1043, 1135], 'become': [813], 'attractive': [815], 'target': [816, 3346, 3357], 'prevention': [819, 836], 'carcinoma,': [822, 1198, 2501], 'recent': [824, 879], 'work': [825, 3716], 'inhibitors': [829, 886, 999, 1106, 1575], 'may': [831, 897, 1067, 4001, 4028, 4125], 'useful': [833], 'treatment': [838], 'other': [840, 1079, 3551, 3664, 3777, 3808, 3992], 'common': [841, 1128], 'epithelial': [842, 1130, 2359, 2404, 3067, 4119], 'malignancies.': [843], 'Numerous': [844], 'studies': [845, 880, 3201, 3373], 'emphasized': [847], 'importance': [849], 'activity': [852, 1044], 'during': [853], 'esophagus,': [858], 'head': [859], 'neck,': [861], 'breast;9-14': [863], 'nonsteroidal': [864], 'antiinflammatory': [865], 'drugs': [866], '(NSAIDs),': [867], 'reduce': [871], 'incidence': [873], 'tumors.15,': [876], '16': [877, 2091], 'demonstrated': [882], 'specific': [884, 1365, 1515], 'significant': [888, 1707, 2397, 2488, 2508, 2713, 2782, 2886, 2928, 2940, 2953, 3090, 3418, 3918, 4074], 'efficacy': [889], 'animal': [891], 'models,': [892], 'suggesting': [893, 4105], 'many': [895], 'NSAIDs': [896, 1010], 'exert': [898], 'their': [899], 'anticancer': [900, 947, 1002, 1015], 'effect,': [901], 'least': [903, 1718, 2381, 2569, 2870, 3405], 'part,': [905], 'via': [906], 'dependent': [909], 'mechanism.': [910], 'Specifically,': [911], 'inhibitor,': [914, 1033], 'celecoxib,': [915], 'dose-dependently': [916], 'inhibited': [917, 935], 'intestinal': [918, 1089, 3272], 'tumor': [919, 937, 1287, 2036, 2471, 3687, 4056], 'multiplicity': [920], 'up': [921], 'compared': [924, 3023, 3099], 'controls': [926], 'Min': [929], 'mouse': [930, 1428], 'model.17': [931], 'Celecoxib': [932], 'effectively': [934, 1535], 'colorectal': [936], 'burden': [938], 'rat': [941], 'azoxymethane': [942], '(AOM)': [943], 'model18,19': [944], 'exerted': [946], 'effects': [948, 1016], 'ultraviolet': [951], 'B–induced': [952], 'skin': [953], 'carcinogenesis': [954], 'model.20,': [955], '21': [956], 'Importantly,': [957, 3089], 'celecoxib': [958], 'reduced': [960, 1489], 'number': [962, 3875, 3893], 'adenomatous': [964, 977, 2439, 3433, 4085], 'polyps': [965], 'double-blind,': [968], 'placebo-controlled,': [969], 'clinical': [970, 990], 'trial': [971, 982], '83': [973], 'patients': [974, 1072, 1233, 3949], 'familial': [976], 'polyposis': [978], '(FAP).': [979], 'Because': [980, 4121], 'not': [984, 1041, 1087, 1780, 2389, 2461, 2474, 2544, 2577, 2659, 2674, 2711, 2785, 2878, 3059, 3104, 3145, 3169, 3440, 3646, 3668, 3700, 3802, 3966, 3988], 'cancer': [987, 1108], 'endpoint,': [988], 'additional': [989, 1229, 4009], 'data': [991, 1094, 1616, 1728, 3238], 'will': [992], 'necessary': [994, 4053], 'determine': [996], 'whether': [997], 'provide': [1000], 'benefit.22': [1003], 'There': [1004, 1810, 1900, 2032, 2166], 'some': [1009], 'such': [1011, 3821], 'sulindac,': [1013, 1024], 'possess': [1014], 'independent': [1019, 3407], 'COX.': [1021], 'prodrug': [1023], 'converted': [1026, 1730], 'vivo': [1028], 'mixed': [1031], 'sulindac': [1034, 1037, 1055, 1084], 'sulfide,': [1035], 'sulfone,': [1038], 'does': [1040, 1086, 2473, 2673], 'physiologically': [1046], 'relevant': [1047], 'doses.23-26': [1048], 'Despite': [1049, 3573], 'its': [1050], 'lack': [1051, 3482, 3679], 'anti-COX': [1053], 'activity,': [1054], 'sulfone': [1056, 1085], 'AOM-induced': [1062], 'tumors,23': [1064], 'suppress': [1068], 'polyp': [1069], 'FAP.': [1074], 'direct': [1076], 'however,': [1078, 2586], 'groups': [1080], 'reported': [1082, 3511, 3520, 3612, 3677, 3866], 'tumorigenesis.26-28': [1090], 'Taken': [1091], 'together,': [1092], 'generated': [1096, 1617], 'compelling': [1098], 'interest': [1099], 'potential': [1102], 'prevention.': [1109], 'With': [1110], 'mind,': [1113], 'we': [1114, 3580, 3628, 3902], 'utilized': [1115, 1596], 'sensitive': [1117, 3230], 'assay': [1119], 'characterize': [1121], 'identify': [1127], 'malignancies': [1131], 'might': [1136, 3502, 3699, 3923], 'effective': [1139], 'approach': [1140], 'suppressing': [1142], 'tumorigenesis.': [1143], 'Case': [1145, 1834], 'Selection': [1146], 'Twenty': [1147], 'random': [1148], 'biopsy': [1153], 'resection': [1155, 1842], 'specimens': [1156, 1843, 1947], 'retrieved': [1158], 'surgical': [1161, 1278], 'pathology': [1162, 1279], 'files': [1163], 'Hospital': [1168], 'cases': [1170, 1225, 2395, 2515, 2756, 2828, 2884, 2957], 'total).': [1171], 'hematoxylin': [1173, 1250, 1460], 'eosin–stained': [1175, 1252], 'slides': [1176, 1253, 1593], 'reviewed,': [1178], 'following': [1181], 'representative': [1182], 'blocks': [1183, 1201, 1301], 'chosen': [1185], 'evaluation:': [1188], 'one': [1189, 1196, 1243, 1884, 2010, 2021, 2029, 2552, 2556, 2845, 2985], 'containing': [1190, 1197, 1202], 'mucosa': [1193, 2280, 2284, 2566, 2600, 2610, 2687, 2701, 2706], '(mucosal': [1194], 'margins),': [1195], 'any': [1200, 2547], 'lesions': [1204, 4000], '(colonic': [1205], 'adenomata': [1206, 2631, 4096], 'situ).': [1211], 'Nonneoplastic': [1212, 2376, 2686, 2865], 'tissue': [1213, 1297, 2265, 2269, 2299, 2303, 2378], 'directly': [1214], 'neoplasms': [1218, 2709], 'study': [1222, 3217, 3234, 3647, 3669, 4072], 'five': [1228], 'control': [1230], 'samples': [1231, 2596], 'without': [1234, 2013, 2988, 3310], 'cancers.': [1235], 'Morphologic': [1236], 'Criteria': [1237], 'Clinical': [1239], 'Data': [1240], 'After': [1241], 'retrieval,': [1242], 'pathologists': [1246], '(R.A.S.)': [1247], 'examined': [1248, 1590], 'classified': [1255, 3658], 'commonly': [1260], 'accepted': [1261, 3630], 'criteria.29': [1262], 'nuclear': [1264, 2108, 2114, 2982], 'grade': [1265, 2007, 2015, 2026, 2109, 2149, 2154, 2159, 2816, 3027, 3896], 'carcinoma': [1268, 1845, 1962, 1999, 2084, 2088, 2100, 2251, 2322, 2340, 2387, 2451, 2575, 2668, 2843, 2853, 2859, 2876, 2910, 3016, 3244, 3501, 3549, 3860], '(DCIS)': [1271, 2103], 'recorded.': [1274, 1725], 'Review': [1275], 'reports': [1280, 3415], 'yielded': [1281], 'information': [1282], 'regarding': [1283, 3239], 'patient': [1284], 'age': [1285, 1932, 1938, 2064, 2070, 2208, 2214], 'stage.30': [1288], 'Immunohistochemistry': [1289], 'Four-micron': [1290], 'sections': [1291, 1336, 1398], 'cut': [1293], 'fixed': [1296], 'mounted': [1303, 1466], 'onto': [1304], 'polylysine': [1305], 'coated': [1306], 'slides.': [1307], 'Sections': [1308, 1774], 'dewaxed': [1310], 'xylene,': [1312], 'rehydrated': [1313], 'descending': [1315], 'alcohols,': [1316], 'blocked': [1318, 1536], 'endogenous': [1320], 'peroxidase': [1321, 1451, 1530], '(3%': [1322], 'H2O2': [1323], 'MeOH)': [1325], 'avidin/biotin': [1327], '(Vector': [1328], 'Blocking': [1329], 'Kit;': [1330], 'Vector': [1331], 'Laboratories,': [1332], 'Burlingame,': [1333], 'CA).': [1334], 'permeabilized': [1338], 'TNB-BB': [1340, 1393], '(0.1M': [1341], 'Tris,': [1342], 'pH': [1343], '7.5,': [1344], '0.15': [1345], 'M': [1346], 'NaCl/0.5%': [1347], 'blocking': [1348, 3380], 'agent/0.3%': [1349], 'Triton': [1350], 'X-100,': [1351], '0.2%': [1352], 'saponin),': [1353], 'incubated': [1355, 1400], 'primary': [1357], 'antibody': [1358, 1550], 'overnight': [1359], '4': [1361, 2172, 2188], '°C.': [1362], 'isoform': [1364, 1514], '(No.': [1368], '160110;': [1369], 'Cayman': [1370], 'Chemical,': [1371], 'Ann': [1372], 'Arbor,': [1373], 'MI)': [1374, 1386], '(PG-27,': [1378], 'Lot': [1379], 'No.': [1380], '0599;': [1381], 'Oxford': [1382], 'Biomedical': [1383], 'Research,': [1384], 'Oxford,': [1385], 'antisera': [1387, 1402, 1540], 'diluted': [1389], '1:500': [1391], 'tissues.': [1396], 'Control': [1397], 'presence': [1405, 1543], '100-fold': [1407, 1545], 'excess': [1408, 1546], 'appropriate': [1411, 3379], 'recombinant': [1413], 'or': [1415, 1418, 1427, 2238, 2331, 2560, 2799, 3307, 3314, 3392, 3568, 3978], 'protein,': [1417, 1548, 3358], 'isotype': [1421], 'matched': [1422], 'immunoglobulin': [1423], 'G': [1424], 'normal': [1425], 'rabbit': [1426], 'serum': [1429], '(Fig.': [1430, 2512, 2932, 3382], '1).': [1431], 'Immunoreactive': [1432, 1518], 'complexes': [1433, 1519], 'detected': [1435, 1521, 2366, 3074], 'tyramide': [1437, 1523, 3293, 3332, 3350], 'signal': [1438, 1524, 3294], 'amplification': [1440, 3295], '(TSA': [1441], 'indirect;': [1442], 'NEN': [1443], 'Life': [1444], 'Science,': [1445], 'Boston),': [1446], 'visualized': [1448, 1527], 'substrate,': [1452], 'AEC.': [1453], 'Slides': [1454], 'then': [1455], 'counter-stained': [1457], 'aqueous': [1459], '(Biomeda': [1461], 'Corp.,': [1462], 'Foster': [1463], 'City,': [1464], 'CA),': [1465], 'crystal': [1468], 'solution': [1469], '(Biomeda),': [1470], 'coverslipped': [1472], '50:50': [1474], 'xylene/Permount': [1475], '(Ladd': [1476], 'Research': [1477], 'Industries,': [1478], 'Williston,': [1479], 'VT).': [1480], 'Figure': [1481, 2425, 2620, 2681, 2897], '1Open': [1482], 'figure': [1484, 2428, 2623, 2684, 2900], 'viewerPowerPoint': [1485, 2429, 2624, 2685, 2901], 'staining': [1487, 1644, 1652, 1710, 1723, 1739, 1778, 1800, 2347, 3031], 'competition': [1491], 'hrCOX-2.': [1493], 'Formalin': [1494], 'archival': [1499], 'prepared': [1502], 'immunohistochemistry': [1504, 1592], 'standard': [1506], 'methods.': [1507], 'Tissues': [1508], 'stained': [1510, 1660], 'antisera.': [1517, 2619], 'amplification,': [1525], 'substrate.': [1531], 'preincubating': [1538], 'hrCOX-2': [1547], 'demonstrating': [1549, 3717], 'specificity.': [1551], '(Left)': [1552], 'Pulmonary': [1553, 1836, 2246, 2257], 'adenocarcinoma': [1554, 2445], 'showing': [1555, 3156], 'immunoreactivity.': [1557, 1809], '(Right)': [1558], 'competition.': [1560], 'Reprinted': [1561], 'permission': [1563], 'AT,': [1566], 'Leahy': [1567], 'KM,': [1568], 'JL.': [1570], 'Potential': [1571], 'utility': [1572], 'chemoprevention': [1577], 'chemotherapy.': [1579], 'Expert': [1580], 'Opin': [1581], 'Invest': [1582], 'Drugs': [1583], '1999;8:1623–38.': [1584], 'Immunohistochemical': [1585, 2220, 2229, 3288], 'Evaluation': [1586], 'R.A.S.': [1587, 1595], 'K.N.K.': [1589, 1787], 'independently.': [1594], 'score': [1599, 1753], '(IHS),': [1600], 'based': [1603], 'German': [1606], 'ImmunoReactive': [1607], 'score;': [1608], 'method': [1610, 3326], 'approximate': [1615], 'systems.31': [1622], 'IHS': [1624, 1733, 1752], 'calculated': [1626, 1828], 'combining': [1628], 'estimate': [1630, 1641], 'percentage': [1633], 'immunoreactive': [1635], 'cells': [1636, 1659, 1807, 2370, 2405, 2730, 3078, 3531, 3787, 4027], '(quantity': [1637], 'score)': [1638], 'intensity': [1645, 1647, 1675, 1740, 1801], '(staining': [1646], 'score),': [1648], 'follows:': [1650], 'no': [1651, 1812], 'scored': [1654, 1661, 1771], '0,': [1656], '1–10%': [1657], '1,': [1663], '11–50%': [1664], '2,': [1666], '51–80%': [1667], '3,': [1669, 1684], '81–100%': [1671], '4.': [1673], 'Staining': [1674], 'rated': [1677], 'scale': [1680], '0': [1682, 1686, 1748, 1769], '=': [1687, 1690, 1693, 1697], 'negative;': [1688], '1': [1689, 1859, 1863, 1925, 1958, 1979, 1983, 2034, 2043, 2059, 2111, 2128, 2146, 2162, 2178, 2186, 2194, 2196, 2199, 2203, 2871, 2947], 'weak;': [1691], 'moderate,': [1694, 1763], '3': [1696, 1849, 1909, 2097, 2133, 2151, 2168], 'strong.': [1698], 'When': [1699, 2994], 'there': [1700, 1705, 3197], 'multifocal': [1702, 2527, 2768, 2969], 'differences': [1708, 1813, 3091, 3613], 'intensities': [1711], 'between': [1712, 1820, 3092, 4037], 'foci,': [1713, 2551, 2798], 'average': [1715], 'intense': [1719, 1722, 2519, 2522, 2528, 2603, 2615, 2760, 2763, 2769, 2961, 2964, 2970], 'raw': [1727], 'multiplying': [1735], 'quantity': [1737], 'scores.': [1741], 'Theoretically,': [1742], 'scores': [1744], 'could': [1745, 1779, 3619, 3655], 'range': [1746, 1939, 2071, 2215], '12.': [1750], 'An': [1751], '9–12': [1755], 'considered': [1757, 1762, 1766, 1785, 3526], 'immunoreactivity,': [1759], '5–8': [1760], '1–4': [1764], 'weak,': [1767], 'negative.': [1773], 'characterized': [1783, 3219], 'equivocal.': [1786], 'used': [1788], 'similar': [1789], 'criteria': [1790, 3498], 'interpretation': [1793, 1816, 3227, 3402], 'IHC': [1795, 1818], 'results,': [1796], 'including': [1797, 2127, 2812, 3270], 'enumeration': [1803], 'exhibiting': [1808], 'overall': [1815], 'results': [1819, 2221, 3360, 3410, 3506, 3593, 3708], 'two': [1822, 3406, 3564], 'pathologists.': [1823, 3408], 'Statistics': [1824], 'values': [1826], 'Fisher': [1831], 'exact': [1832], 'method.': [1833], 'Composition': [1835], 'Nineteen': [1838], 'pulmonary': [1841, 2377, 2444, 2469, 2485, 3422, 3552, 3631, 3705], 'contained': [1844, 1957, 1984, 2020, 2082, 2098], '(13': [1846], '[ACAs],': [1848], 'squamous': [1850, 2309, 2449], '[SCCs],': [1853], 'large': [1855, 2249, 2338, 2504, 3841], 'adenosquamous': [1860, 2253, 2342, 2500], 'carcinoma),': [1861], 'carcinoid': [1866, 2470, 3686], 'tumor.': [1867], 'Of': [1868, 2826], 'ACAs,': [1870, 2498, 2793], '11': [1871, 2048], 'poorly': [1878, 1890, 1959, 1980, 1988, 2135, 2795, 2801, 3148, 3649, 3660], 'differentiated.': [1879, 1899, 2136], 'Focal': [1880], 'bronchioloalveolar': [1881, 2550, 3487, 3500, 3517, 3538, 3548], 'patterns': [1882], 'accompanied': [1883], 'ACA': [1887, 2273, 2797, 3750], 'both': [1889, 1985, 2503], 'ACAs.': [1892, 1966, 3492], 'All': [1893], 'SCCs': [1896, 3134, 3578, 3662], '7': [1902, 2053], 'T1': [1903, 2035], '(4': [1905], 'N0': [1907, 2170, 2176, 2184, 2192], 'N1),': [1911], 'T2': [1913, 2039, 2190], '(3': [1915, 2041, 2175, 2191], 'N0,': [1917, 2042, 2052], '5': [1918, 2038], 'N1,': [1920, 2044, 2054], 'N2),': [1924, 2047, 2057], 'T4N0,': [1926], 'TxNxs.': [1929], 'mean': [1931, 2063, 2207], '63': [1934], 'years,': [1935, 2067, 2211], '44–85': [1941], 'years.': [1942, 2074, 2218], 'Colonic': [1943, 2272], '18': [1949], 'colectomies': [1950, 1956], 'endoscopic': [1953, 2018], 'biopsies.': [1954], 'neuroendocrine': [1961, 2466, 2583, 2664, 2667, 2728, 2803, 3157, 3273, 3704, 3786, 3819], '17': [1964], 'Five': [1967, 1991, 2116], 'differentiated,': [1970, 1981, 2122, 2126], '(including': [1974], 'metastatic': [1976], 'carcinomas),': [1977], 'areas.': [1990], 'intimately': [1996], 'associated': [1997, 2000, 2143], 'lesions:': [2001], 'four': [2002], 'tubulovillous': [2003, 2011, 2022, 2630, 2810, 3754, 4095], 'high': [2006, 2014, 2025, 2107, 2158, 2815, 3320, 3462, 3911], 'dysplasia': [2008, 2027], 'adenoma': [2012, 2023], 'dysplasia.': [2016], 'biopsies': [2019, 2081], 'tubular': [2030, 2808, 3752, 4093], 'adenoma.': [2031], '(T1N0),': [2037], 'T3': [2049], '(2': [2051, 2105], 'TxNx.': [2061, 2205], '71': [2066], '49–88': [2073], 'Breast': [2075, 2864], 'Seventeen': [2077], '(1': [2085], '[ILC]': [2089], '[IDCs]),': [2095], 'only': [2104, 3352, 3525, 3629], 'intermediate': [2113, 2153], 'grade).': [2115], 'IDCs': [2119, 2944], '8': [2123], 'apocrine': [2130, 2164, 2992], 'differentiation,': [2131], 'Seven': [2137], 'DCIS;': [2145], 'had': [2147, 2152, 2157], 'nuclei,': [2150, 2155, 2160], 'differentiation.': [2165, 2467, 2665, 2993, 3158], 'T1a': [2169], 'tumors,': [2171, 3167, 3174, 3964, 3971], 'T1b': [2174], 'N1bii),': [2179], '6': [2180], 'T1c': [2182], '(5': [2183], 'N1bi),': [2187, 2195], 'TxN0,': [2198], 'TxN1bi,': [2201], '57': [2210], '32–90': [2217], 'Table': [2225, 2227], '1.': [2226, 2228], 'Expression': [2230], 'COX-2aa': [2232], 'Only': [2233, 2326], 'show': [2236, 2329, 2390, 2578, 2879, 3581], 'listed.': [2242, 2335], 'Tissue': [2243], '(%)': [2245], 'ACAbb': [2247], 'Includes': [2248, 2337], 'carcinoma.': [2254, 2343, 2804, 3253], '15/16': [2255], '(94)': [2256], 'SCC': [2258, 3586, 3618, 3634], '2/3': [2259], '(67)': [2260], 'Carcinoid': [2261], '0/1': [2262, 2304], '(0)': [2263, 2271, 2286, 2305], 'Adjacent': [2264, 2279, 2298], '4/14': [2266], '(29)': [2267], 'Distant': [2268, 2283, 2302, 2717], '0/5': [2270], '12/17': [2274], '(71)': [2275], 'Adenoma': [2276], '6/7': [2277], '(86)': [2278], '3/15': [2281], '(20)': [2282], '0/6': [2285], 'Mammary': [2287, 2291], 'IDC': [2288], '6/16': [2289], '(38)': [2290], 'ILC': [2292, 2948], '1/1': [2293], '(100)': [2294], '8/10': [2296], '(80)': [2297], '3/18': [2300], '(17)': [2301], 'ACA:': [2306], 'adenocarcinoma;': [2307], 'SCC:': [2308], 'carcinoma;': [2311, 2315, 2319, 4083], 'IDC:': [2312], 'ILC:': [2316], 'DCIS:': [2320], 'situ.': [2324], 'b': [2336], 'General': [2345], 'pattern': [2348, 2645, 3032], 'cytoplasmic': [2350, 2643, 3034], 'granular.': [2352, 3036], 'obvious': [2357, 3065], 'cells;': [2360, 3068], 'very': [2361, 2521, 2762, 2963, 3069, 3224, 3758], 'reactivity': [2363, 2523, 2616, 2764, 2965, 3071], 'focal': [2368, 3076], 'endothelial': [2369, 3077], 'occasional': [2372, 3080], 'Lung': [2375], 'sampled': [2379, 2567, 2868], 'cm': [2383, 2571, 2872], 'appreciable': [2391, 2579, 2880], 'reactivity).': [2393], 'Two': [2394], 'peritumor': [2401, 2408, 2418], 'benign': [2402, 2891], 'bronchial': [2403, 2420], 'bronchiolar': [2409, 2436, 3427, 4091], 'metaplastic': [2410], 'mucosa.': [2411], 'Weak': [2412], 'found': [2416, 3459], 'pneumocytes,': [2419], 'submucosal': [2421], 'glands,': [2422], 'chondrocytes.': [2424], '2Open': [2426], 'strongly': [2432, 2536, 2627, 3121], 'atypical': [2435, 4084], 'metaplasia': [2437, 3428], '(atypical': [2438, 3432, 4090], 'hyperplasia)': [2440], '(A)': [2441, 2635, 2913], '(B)': [2446], '(C).': [2455], 'observed': [2462, 2545, 2786, 2841, 2851, 3040, 3146], 'illustrated': [2478, 2678, 2697, 2722], 'D.': [2480], 'levels': [2489, 2509, 2714, 2929, 3003, 3190, 3463, 3912], 'COX-2;': [2491, 2693, 2781, 2941], '67%': [2492], 'SCCs,': [2495], '92%': [2496], '2).': [2513], 'Most': [2514, 2755, 2955], 'diffuse,': [2517, 2758, 2959], 'few': [2525, 2766, 2967], 'reactivity.': [2529, 2581, 2770, 2882, 2971], 'Squamous': [2530], 'keratinized': [2539], 'Significant': [2541, 3140], 'SCC,': [2555], 'ACA,': [2559], 'carcinoid.': [2562], 'Colon': [2563], 'Non-neoplastic': [2564], 'Scattered': [2582], 'crypt': [2584, 2729], 'cells,': [2585, 3274, 3820, 4050], 'intensity.': [2594], 'Some': [2595], 'diffuse': [2612], 'but': [2613, 3168, 3457, 3674, 3965], 'weakly': [2614], 'anti–COX-2': [2618], '3Open': [2621], '(B).': [2640, 2918], 'granular,': [2642], 'perinuclear': [2644], 'particulary': [2649], 'evident': [2650, 2733], 'images.': [2653], 'seen': [2660, 2906], 'C.': [2680], '4Open': [2682], 'often': [2691], 'expresses': [2692], 'phenomenon': [2695, 3986, 4112], '(A).': [2702], 'COX-2.': [2716, 3523], 'particularly': [2732], '(indicated': [2737], 'arrows).': [2739], 'Seventy-one': [2740], 'ACAs': [2744, 2779, 3132, 3431, 3553, 3731], 'level': [2752], '(Figs.': [2753], '3,4).': [2754], 'Seventy-five': [2771], '40%': [2788], 'Eighty-six': [2805], 'adenomas,': [2811, 3755], 'those': [2813, 3414, 3510], 'dysplasia,': [2817], 'level.': [2825, 2954], 'coincident': [2831], 'exceeded': [2839], 'case,': [2846], 'fell': [2847], 'short': [2848], 'three': [2855, 4078], 'cases,': [2856], 'equaled': [2858], 'one.': [2863], 'parenchyma': [2867], 'Rare': [2883], 'perineoplastic': [2890], 'acini': [2893], '5Open': [2898], 'Strong': [2902], 'Together,': [2919], '5).': [2933], 'Forty-one': [2934], '38%': [2942], 'positive': [2956, 4032], '80%': [2974], 'DCISs': [2976], 'strongly,': [2979], 'regardless': [2980, 3466], 'grade.': [2983], 'lesion': [2987], 'coexisted,': [2999], 'concordant': [3002], 'except': [3007], 'one,': [3008], 'less': [3019], 'DCIS.': [3028, 3139], 'several': [3053], 'sites': [3057], '(data': [3058], 'shown).': [3060], 'general,': [3084], 'ubiquitous.': [3088], 'neoplastic': [3096, 3192, 3530, 3999, 4026], 'detected.': [3105], 'DISCUSSION': [3106], 'up-regulated': [3109], 'suggests': [3176, 3694, 3972], 'possibility': [3178, 3696, 3974], 'field': [3182, 3286], 'effect.': [3183, 3287, 3980], 'Although': [3196, 3795], 'previous': [3200, 3715], 'detection': [3205, 3303], 'breast,': [3215, 4104], 'careful': [3225, 3257], 'morphologic': [3226, 3258], 'along': [3228], 'techniques.': [3232], 'This': [3233], 'provides': [3236], 'novel': [3237], 'situ,': [3246], 'putative': [3248, 4079], 'precursor': [3249], 'benefits': [3255], 'examination': [3259], 'include': [3260], 'documentation': [3262], 'types': [3266], 'paranuclear,': [3276], 'granular': [3277], 'distribution': [3278], '(TSA),': [3296], 'powerful': [3298], 'new': [3299], 'technology': [3300], 'permits': [3302], 'abundance': [3306], 'labile': [3308], 'proteins': [3309], 'loss': [3311, 3365], 'resolution': [3313, 3321], 'increased': [3315, 3952, 4005], 'background.32': [3316], 'sensitivity': [3318], 'achieved': [3322], 'TSA': [3325], 'attributed': [3328], 'unique': [3331], 'chemistry.': [3333], 'extremely': [3335], 'rapid': [3336], 'reaction': [3337], 'rate': [3338], 'minimizes': [3339], 'diffusion': [3340], 'substrate': [3343], 'protein;': [3347], 'covalently': [3348], 'bound': [3349], 'deposited': [3353], 'proximal': [3354], 'minimal,': [3362], 'if': [3363, 3635], 'any,': [3364], 'resolution.33': [3367], 'We': [3368, 3438, 3493, 3524, 3644, 3666], 'performed': [3370], 'extensive': [3371], 'validation': [3372], 'before': [3374], 'analysis,': [3375], 'experiments': [3381], '1),': [3383], 'corroboration': [3384], 'Western,': [3386], 'quantitative': [3387], 'reverse': [3388], 'transcription–polymerase': [3389], 'chain': [3390], 'reaction/TAQman': [3391], 'hybridization': [3395], 'paired': [3397], 'consistent': [3400, 3710], 'immunopathologic': [3401], 'comparable': [3412, 3595], 'describe': [3417], 'ACAs34,35': [3423], 'patches': [3425], 'hyperplasia': [3434, 4086], 'lung).': [3437], 'find': [3441], 'gradient': [3445], 'decreased': [3447], 'increasing': [3449], 'grade,': [3451, 3469, 3740], 'described': [3452, 3766, 3855, 3990], 'Wolff': [3454, 3513, 3597], 'et': [3455, 3472, 3514, 3590, 3598, 3602, 3747, 3769, 3864, 3882], 'al.,36': [3456, 3515], 'instead': [3458], 'apparently': [3460], 'constant': [3461], 'Hida': [3471, 3589], 'al.': [3473, 3591, 3865, 3883], 'suggest.35': [3474], 'One': [3475], 'exception': [3476], 'trend': [3479], 'foci': [3488], 'think': [3494], 'led': [3504], 'differ': [3508], 'whose': [3516], 'noninvasive': [3527], 'proliferations': [3528], 'lined': [3533], 'preexisting': [3534], 'alveoli': [3535], 'represent': [3537], 'carcinomas.37': [3539], 'If': [3540, 3771], 'observations': [3542, 4062], 'divergent': [3544], 'validated,': [3556], 'it': [3557, 3772, 3804], 'would': [3558, 3792], 'support': [3559, 4055], 'hypothesis': [3561], 'arise': [3566], 'and/': [3567], 'progress': [3569], 'mechanisms.': [3572], 'numbers': [3576], 'studied,': [3579], 'do': [3588], "al.'s": [3599], 'Huang': [3601], "al's36,37": [3603], 'confirmed': [3607], 'immunoblot': [3609], 'analysis.38': [3610], 'due': [3621, 3953], 'variations': [3623], 'case': [3625], 'selection': [3626], 'methods;': [3627], 'they': [3636, 3675], 'convincing': [3638], 'keratinization': [3639], 'and/or': [3640], 'unequivocal': [3641], 'intercellular': [3642], 'bridges.': [3643], 'unclassified': [3648], 'nonsmall': [3651], 'investigators.': [3665, 3993], 'small': [3670], 'either,': [3673], 'expression.36-38': [3681], 'finding': [3683, 3780, 3800, 3916], 'series': [3690, 3842], 'lacked': [3691], 'tumors.': [3706], 'expand': [3713], 'overexpression': [3718, 4107], 'carcinoma.39-44': [3723], 'consistently': [3727], 'overexpressed': [3728], 'inversely': [3736], 'Sano': [3746], 'al.39': [3748], 'precursors,': [3751], 'even': [3762], 'greater': [3763], 'Eberhart': [3768], 'al.40': [3770], 'validated': [3775], 'investigators,': [3778], 'crypts': [3791], 'compelling.44': [3794], 'significance': [3797, 3926], 'certain,': [3803], 'noteworthy': [3806], 'gastrointestinal': [3809], 'organs,': [3810], 'pancreas,': [3813], 'contain': [3814], 'populations': [3816, 3936], 'pancreatic': [3824], 'islets': [3825], 'expressed.45': [3830], 'report': [3832, 3910], 'unprecedented,': [3848], 'knowledge.': [3851], 'Liu': [3852], 'Rose': [3854], 'lines.46': [3862], 'Hwang': [3863], 'carcinomas,47': [3879], 'Parrett': [3881], 'unspecified': [3892], '"high': [3895], 'tumors."48': [3898], 'To': [3899, 3981], 'knowledge,': [3901, 3983], 'alone': [3903], 'expression.': [3914], 'profound': [3925], 'because': [3927], 'changing': [3930], 'epidemiology': [3931], 'benefit': [3938], 'mammographic': [3940], 'screening;': [3941], 'prevalence': [3943], 'among': [3946], '"breast': [3947], 'cancer"': [3948], 'steadily': [3951], 'early': [3955, 4111, 4137], 'detection.49': [3956], '"field"': [3977], '"landscaping."50': [3979], 'particular': [3985], 'Increased': [3994], 'correlate': [4002], 'risk': [4006], 'developing': [4008], 'cancers': [4010], 'vicinity': [4017], 'neoplasms.': [4019], 'Indeed,': [4020], 'derived': [4022, 4123], 'synthesized': [4024], 'act': [4029], 'modulators': [4033], 'cross-talk': [4036], 'transformed': [4039], 'activation': [4042], 'stromal': [4045], 'elements': [4046], '(i.e.,': [4047], 'vasculature,': [4048], 'dendritic': [4051], 'cells)': [4052], 'metastasis.': [4059], 'Obviously,': [4060], 'preliminary': [4064], 'should': [4066], 'investigated': [4068], 'further.': [4069], 'current': [4071], 'documents': [4073], 'precursors': [4080], 'metaplasia),': [4092], 'relatively': [4110], 'genesis': [4115], 'neoplasm.': [4120], 'metabolites': [4124], 'increase': [4126], 'resistance': [4127], 'apoptosis,51,': [4129], '52': [4130], 'angiogenesis53,54': [4132], 'impair': [4134], 'surveillance,55': [4136], 'prophylactic': [4138], 'intervention': [4139], 'inh': [4143]}, 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