Mammalian RGS Proteins: Barbarians at the Gate

Name: Work Video:
Duration: 3 min 30 s
David M. Berman; Alfred G. Gilman
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1354, 2352, 2419, 2664, 2856, 3103, 3459, 3829, 3957, 4368, 4505], 'proteins.': [75, 551], '1The': [76, 105], 'abbreviations': [77, 106], 'used': [78, 107], 'are:': [79, 108], 'protein,': [81, 101, 110, 130, 355, 1330], 'regulatory': [85, 114], 'protein;': [86, 89, 115, 118, 2379], 'GAP,': [87, 116, 1948], 'GTPase-activating': [88, 117, 452], 'RGS,': [90, 119], 'regulator': [91, 120], 'protein': [94, 123, 260, 322, 332, 425, 463, 547, 561, 623, 686, 1080, 1117, 1261, 1275, 1306, 1355, 1649, 1945, 2420, 2665, 2823, 2857, 3108, 3163, 3230, 3375, 3396, 3456, 3460, 3470, 3853, 3923, 3949, 4112, 4149, 4303, 4322, 4369, 4398, 4461, 4494, 4506], 'signaling;': [95, 124], 'GTPγS,': [96, 125], 'guanosine': [97, 126], '5′-3-O-(thio)triphosphate;': [98, 127], 'GAIP,': [99, 128], 'Gα-interacting': [100, 129], 'an': [102, 131, 302, 329, 1273, 1328, 1357, 2469, 2836, 3001, 3096, 3113, 3379, 3399, 3454, 3517, 4448], 'RGS': [103, 132, 550, 560, 611, 685, 1019, 1045, 1073, 1106, 1139, 1274, 1329, 1648, 1672, 1847, 1957, 2636, 2693, 2733, 2804, 2843, 2903, 3032, 3162, 3374, 3455, 3503, 3520, 3810, 3852, 3922, 3948, 3983, 4096, 4111, 4115, 4148, 4163, 4302, 4362, 4397, 4460, 4493, 4516], 'protein.': [104, 1042], 'protein.Collectively,': [133], 'mammalian': [134, 684, 1008, 1138, 3926, 3947], 'contain': [136, 1016, 4220], 'hundreds': [137], 'protein-coupled': [140, 3958], 'receptors': [141], 'dozens': [143], 'effectors.': [145], 'It': [146, 474, 2287, 3909], 'is': [147, 299, 404, 446, 475, 574, 1029, 1127, 1262, 1282, 1315, 1338, 1387, 1565, 1596, 1632, 1711, 1719, 1940, 2288, 2367, 2407, 2450, 2564, 2826, 3112, 3123, 3143, 3155, 3326, 3778, 3845, 3865, 3910, 3934, 4271], 'difficult': [148, 2777], 'count': [150], 'functionally': [151, 617], 'distinct': [152], 'because': [155, 1707, 2884], 'we': [156, 2816, 3804, 4443, 4469], 'do': [157, 3805, 4178], 'not': [158, 1095, 1941, 2233, 2657, 2797, 2846, 2969, 3094, 3199, 3346, 3364, 3464, 3806], 'understand': [159], 'significance': [161], 'heterogeneity': [164], 'offered': [165], 'possible': [168, 3156], 'combination': [169], '16': [171], 'α,': [172, 3175], '5': [173], 'β,': [174], '12': [178], 'γ': [179, 273, 3039], 'subunits': [180, 262, 2667, 4378, 4508], '(for': [181], 'reviews,': [182], 'see': [183], 'Refs.1Gilman': [184], 'A.G.': [185, 230, 1195, 1449, 1475, 1735, 1793, 2033, 2753, 2933, 3056, 3572, 3730], 'Annu.': [186], 'Rev.': [187], 'Biochem.': [188, 232, 911], '1987;': [189, 3901], '56:': [190], '615-649Crossref': [191], 'PubMed': [192, 207, 222, 240, 254, 511, 524, 647, 669, 712, 743, 815, 832, 853, 877, 896, 918, 946, 971, 988, 1000, 1166, 1185, 1205, 1224, 1241, 1461, 1482, 1697, 1747, 1800, 1819, 1865, 1884, 1906, 1928, 1969, 2004, 2045, 2099, 2118, 2140, 2161, 2494, 2612, 2766, 2946, 3021, 3063, 3085, 3278, 3585, 3621, 3643, 3665, 3698, 3720, 3743, 3889, 3904, 3972, 4024, 4054, 4212, 4238, 4264, 4296], 'Scopus': [193, 208, 223, 241, 255, 512, 525, 648, 670, 713, 744, 816, 833, 854, 878, 897, 919, 947, 972, 1001, 1167, 1186, 1206, 1225, 1242, 1462, 1483, 1698, 1748, 1801, 1820, 1866, 1885, 1907, 1929, 1970, 2005, 2046, 2100, 2119, 2141, 2162, 2495, 2613, 2767, 2947, 3022, 3064, 3086, 3279, 3586, 3622, 3644, 3666, 3699, 3721, 3744, 3766, 3890, 3905, 3973, 4025, 4055, 4213, 4239, 4265, 4297], '(4682)': [194], 'Google': [195, 210, 225, 243, 257, 514, 527, 650, 672, 715, 746, 761, 818, 835, 856, 880, 899, 921, 949, 974, 989, 1003, 1169, 1188, 1208, 1227, 1244, 1442, 1464, 1485, 1700, 1750, 1803, 1822, 1868, 1887, 1909, 1931, 1972, 2007, 2048, 2102, 2121, 2143, 2164, 2497, 2615, 2769, 2949, 3024, 3066, 3088, 3281, 3588, 3624, 3646, 3668, 3701, 3723, 3746, 3768, 3892, 3907, 3975, 4027, 4057, 4072, 4215, 4241, 4267, 4299], 'Scholar,': [196, 211, 226, 244, 515, 747, 819, 836, 857, 881, 900, 950, 975, 990, 1170, 1189, 1209, 1228, 1443, 1465, 1804, 1869, 1888, 1910, 2103, 2144, 2616, 3067, 3625, 3647, 3702, 3724, 3747, 3893, 4058, 4073, 4242], '2Bourne': [197], 'H.R.': [198, 659, 805, 3009, 3631, 3686], 'Sanders': [199], 'D.A.': [200], 'McCormick': [201], 'F.': [202, 2487, 2605], 'Nature.': [203, 520, 828, 1220, 1237, 1815, 1880, 3617, 3968], '1990;': [204], '348:': [205], '125-132Crossref': [206], '(1825)': [209], '3Simon': [212], 'M.I.': [213, 842, 1155, 1854, 1916, 3073], 'Strathmann': [214], 'M.P.': [215], 'Gautam': [216], 'N.': [217, 1211, 1871, 4001, 4013], 'Science.': [218, 1693, 1796, 1965, 2490, 2608], '1991;': [219], '252:': [220], '802-808Crossref': [221], '(1576)': [224], '4Hepler': [227], 'J.R.': [228, 2749, 2929, 3570, 3728], 'Gilman': [229, 1194, 1448, 1474, 1734, 1792, 2032, 2752, 2932, 3055, 3571, 3729], 'Trends': [231], 'Sci.': [233, 705, 846, 889, 1159, 1178, 1858, 2092, 2111, 2133, 2759, 2939, 3578, 3736, 4017, 4205, 4231, 4257, 4289], '1992;': [234, 505, 521], '17:': [235], '383-387Abstract': [236], 'Full': [237, 251, 508, 642, 644, 664, 666, 810, 812, 872, 874, 941, 943, 966, 968, 983, 985, 1200, 1202, 1456, 1458, 1742, 1744, 1901, 1903, 1923, 1925, 1999, 2001, 2040, 2042, 3016, 3018, 3080, 3082, 3273, 3275, 3638, 3640, 3660, 3662, 3693, 3695, 3715, 3717], 'Text': [238, 252, 509, 643, 645, 665, 667, 811, 813, 873, 875, 942, 944, 967, 969, 984, 986, 1201, 1203, 1457, 1459, 1743, 1745, 1902, 1904, 1924, 1926, 2000, 2002, 2041, 2043, 3017, 3019, 3081, 3083, 3274, 3276, 3639, 3641, 3661, 3663, 3694, 3696, 3716, 3718], 'PDF': [239, 253, 510, 646, 668, 814, 876, 945, 970, 987, 1204, 1460, 1746, 1905, 1927, 2003, 2044, 3020, 3084, 3277, 3642, 3664, 3697, 3719], '(919)': [242], '5Neer': [245], 'E.J.': [246, 977], 'Cell.': [247, 504, 660, 772, 806, 1196, 2036, 2156, 3884, 3899, 4081], '1995;': [248, 709, 1439, 2096, 2158, 3886], '80:': [249], '249-257Abstract': [250], '(1283)': [256], 'Scholar).GDP-bound': [258], 'α': [261, 278, 364, 430, 2421, 2666, 2858, 2890, 3194, 3241, 3252, 3461, 4377, 4507], 'high': [264, 1976, 2009, 2650], 'affinity': [265, 1493, 1624, 1829, 1935, 2010, 3136, 3168], 'for': [266, 540, 1130, 1407, 1497, 1504, 1548, 1557, 1627, 1647, 1670, 1762, 1772, 1830, 1834, 1936, 1978, 2077, 2790, 2838, 2907, 2924, 3090, 3099, 3139, 3169, 4160, 4367, 4451], 'tight': [268], 'complex': [269, 1500, 1832, 1939, 2024], 'β': [271], 'subunits.': [274, 2422, 2891], 'This': [275, 674, 1538, 2892], 'interaction': [276, 285, 681, 2011, 2780, 3117, 3452], 'with': [279, 292, 323, 388, 435, 450, 678, 687, 1307, 1356, 1571, 1602, 1770, 1845, 2184, 2225, 2240, 2259, 2265, 2332, 2336, 2348, 2458, 2528, 2617, 2642, 2774, 2848, 2855, 2888, 3000, 3031, 3120, 3201, 3234, 3398, 3408, 3439, 3446, 3457, 4098, 4311, 4349, 4504], 'βγ': [280, 1097], 'occludes': [281], 'sites': [283, 2519, 2577, 4173], 'both': [287, 1032, 1979, 2387, 2953, 3240, 3475], 'molecules': [291, 1589], 'downstream': [293, 3237], 'effectors,': [294], 'inactive': [297, 2452], 'state': [298, 1525, 2258], 'maintained': [300], 'extremely': [303], 'slow': [304, 413, 437], 'rate': [305, 439, 1526, 1540, 1594, 1683, 2360], 'dissociation': [307, 339, 368, 428, 1559, 4381], 'GDP': [309, 422, 1113, 2242], 'from': [310, 371, 431, 596, 1563, 2558, 2592, 3214, 3549, 3775, 4382], 'oligomer': [312], '(k': [313, 414, 1530], '∼': [314, 416], '0.01/min).': [315], 'An': [316, 4301], 'agonist-bound': [317], 'receptor': [318, 1359, 1367, 3959], '(typically': [319], '35–60-kDa': [321], 'seven': [324], 'plasma': [325], 'membrane-spanning': [326], 'helices)': [327], 'activates': [328], 'appropriate': [330, 1358], 'poorly': [334], 'understood': [335, 4135], 'interactions': [336, 387, 449, 1568, 2331, 2824, 3238, 3358, 3492, 4093, 4503, 4514], 'promote': [338], 'GDP.': [341], 'High': [342], 'intracellular': [343], 'concentrations': [344, 1519, 1534], 'GTP': [346, 359, 420, 441, 1257, 1308, 1336, 1381, 1410, 1515, 1528, 1685, 2362, 2384, 2464], 'ensure': [347], 'transient': [349, 3124], 'existence': [350, 3790], 'nucleotide-free': [353], 'binding': [357, 1423, 2226, 2897, 2909, 2925, 3092, 3383, 3466], 'causes': [360], 'conformational': [361], 'changes': [362], 'result': [366, 3774], 'GTP-α': [370], 'βγ.': [372, 3204, 3243, 4383], 'Both': [373], 'complexes': [376, 1783], 'can': [377, 1383, 1416, 1582, 2905, 4463], 'then': [378, 1316, 1384], 'activate': [379, 2719, 2726], 'inhibit': [381, 2716, 2722], 'pathways': [383, 484, 2809, 3545], 'engaging': [385], 'effectors': [389, 432, 480, 2885, 3202, 4366], 'such': [390, 471, 1413, 2446, 3195, 3515, 3776, 3792], 'as': [391, 460, 472, 486, 603, 618, 1110, 1148, 1414, 1421, 1645, 1678, 1680, 2294, 2453, 2671, 2699, 2737, 3188, 3378, 3516, 3554, 4119, 4306, 4512], 'adenylyl': [392, 2717, 3311, 3387, 3413, 3447, 3472, 3478, 3565, 3784, 4350], 'cyclases,': [393, 2718], 'phospholipases,': [394], 'cyclic': [395, 2727, 3044, 3301], 'nucleotide': [396, 2210, 2728], 'phosphodiesterases,': [397], 'ion': [399], 'channels.': [400], 'Termination': [401], 'dependent': [405], 'on': [406, 488, 1031, 1096, 1276, 1379, 2436, 2806, 3441], 'GTPase': [408, 1122, 1585, 2455, 3224], 'activity': [409, 1397, 1586, 2079, 3225, 3340, 3500], 'α.': [411], 'Typically': [412], 'cat': [415], '4/min)': [417], 'hydrolysis': [418, 442, 1255, 1278, 1337, 1382, 1516, 1529, 1542, 1686, 2228, 2329, 2363, 2385, 2465, 2971], '(which': [423], 'remains': [424], 'bound)': [426], 'promotes': [427], 'reassociation': [434], 'βγ.The': [436], 'intrinsic': [438, 1539], 'Gα': [444, 490, 541, 1067, 1090, 1260, 1305, 1641, 1710, 1779, 2195, 2304, 2378, 2580, 2645, 2975, 3121, 3141, 3227, 3395, 3469, 4099], 'regulated': [447, 1720, 3813, 3867], 'so-called': [451], 'GAPs.': [455, 3555], 'GAPs': [456, 487, 539, 1149, 1412, 1650, 2700, 2738, 2789], 'were': [457, 615, 1104], 'first': [458, 1294, 3390, 3851], 'recognized': [459], 'regulators': [461, 573, 620, 1077], 'synthesis': [464, 2995, 3677], 'factors': [465], 'low': [467, 2344, 3144], 'molecular': [468, 2345], 'weight': [469, 2346], 'GTPases': [470, 2347], 'Ras.': [473], 'now': [476, 1949, 3402, 4466], 'appreciated': [477], 'certain': [479, 1671, 3502], 'protein-regulated': [483, 3830], 'act': [485, 1083, 1109, 1147, 1420, 2698, 2736, 3187, 3377, 4117], 'cognate': [489, 1726], '(6Berstein': [492], 'G.': [493, 3353, 3417, 3423, 4357], 'Blank': [494], 'J.L.': [495], 'Jhon': [496], 'D.Y.': [497], 'Exton': [498], 'J.H.': [499, 755, 827, 1217, 1877, 3616, 3761, 3967, 4066], 'Rhee': [500], 'S.G.': [501], 'Ross': [502, 1691, 1963, 1991], 'E.M.': [503, 1434, 1692, 1964, 1992], '70:': [506], '411-418Abstract': [507], '(346)': [513], '7Arshavsky': [516], 'V.Y.': [517, 1477, 3058], 'Bownds': [518], 'M.D.': [519], '357:': [522], '416-417Crossref': [523], '(218)': [526], 'Scholar)': [528, 651, 762, 777, 1751, 2049, 3282, 4028], 'there': [531, 3801, 4180], 'exists': [532], 'large,': [534], 'newly': [535], 'discovered': [536, 616, 4305], 'family': [537, 562, 1057, 1958, 3164, 4344], 'known': [543, 1011, 1950, 3838], 'asregulators': [544], 'Although': [552, 2815, 3474, 3800], 'one': [553, 2562, 2674, 3940], 'critical': [554, 2274, 2538], 'biochemical': [555], 'property': [556], 'this': [558, 1025, 1831, 2069, 2655, 2779, 3373, 3862, 3913, 3932, 4454], 'novel': [559], 'has': [563, 1398, 1826, 1974, 2065, 2656, 2781, 2914, 3401, 3937, 3985], 'defined,': [565, 4511], 'knowledge': [566], 'requisite': [569], 'regulation': [570, 3101, 3797, 3844, 3978, 4146, 4491], 'negligible.': [575], 'There': [576, 1126, 3936, 4151], 'hints,': [578, 3803], 'however,': [579], 'may': [583, 1047, 1543, 2253, 2322], 'be': [584, 1048, 1385, 1417, 1599, 1952, 2356, 2830, 2981, 3095, 3494, 3506, 3855, 3915, 4157, 4464, 4473, 4510], 'poised': [585, 4371], 'centers': [587], 'intercept': [591, 4373], 'activated': [592, 4123], 'proteins,': [594, 2637, 2976, 3033], 'acting,': [595], "protein's": [599], 'point': [600, 2553], 'view,': [602], '"barbarians': [604], 'gate"': [607], 'cellular': [609, 4520], 'signaling.The': [610], 'Protein': [612], 'FamilyRGS': [613], 'negative': [619, 1076, 2434, 3100], 'Saccharomyces': [626], 'cerevisiae': [627], '(Sst2p)': [628], '(reviewed': [629], 'Ref.': [631, 2593], '8Dohlman': [632], 'H.G.': [633, 932, 2146, 3874], 'Thorner': [634, 933], 'J.': [635, 636, 756, 863, 866, 934, 935, 1450, 1690, 1736, 1806, 1895, 1917, 1962, 1984, 1988, 1993, 3010, 3074, 3267, 3416, 3632, 3654, 3687, 3709, 3897, 4007, 4067], 'Biol.': [637, 773, 867, 936, 962, 979, 996, 1451, 1737, 1896, 1918, 1994, 2157, 3011, 3075, 3268, 3633, 3655, 3688, 3710, 3885, 3900, 4082], 'Chem.': [638, 868, 937, 1452, 1738, 1897, 1919, 1995, 3012, 3076, 3269, 3634, 3656, 3689, 3711], '1997;': [639, 869, 893, 915, 938, 980, 997, 1182, 1479, 1694, 1898, 1920, 1966, 1996, 2037, 2115, 2137, 2491, 2609, 2763, 2943, 3013, 3060, 3077, 3270, 3582, 3635, 3657, 3690, 3712, 3740, 3763, 4021, 4209, 4235], '272:': [640, 870, 939, 1899, 1921, 1997, 3014, 3078, 3271, 3636, 3658, 3691, 3713], '3871-3874Abstract': [641, 940], '(447)': [649, 948], 'Caenorhabditis': [653], 'elegans': [654], '(EGL10)': [655], '(9Koelle': [656, 802], 'M.R.': [657, 803, 992, 2479, 2597], 'Horvitz': [658, 804], '1996;': [661, 807, 829, 850, 963, 1163, 1197, 1221, 1238, 1453, 1739, 1862, 1881, 3618, 3969, 4261, 4293], '84:': [662, 808], '115-125Abstract': [663, 809], '(475)': [671, 817], 'Scholar).': [673, 922, 1004, 1486, 1701, 1932, 2165, 2498, 2770, 2950, 3025, 3669, 3769, 3908, 4086, 4216, 4300], 'information': [675, 4489], 'converged': [676], 'quickly': [677], 'demonstrations': [679], 'Gαi3': [688], 'two-hybrid': [691], 'screen': [692], '(10De': [693, 2080], 'Vries': [694, 2081, 4244, 4276], 'L.': [695, 904, 2082, 2483, 2601, 3995, 4005, 4245, 4249, 4277, 4281], 'Mousli': [696, 2083], 'M.': [697, 960, 1890, 2084, 3349], 'Wurmser': [698, 2085], 'A.': [699, 708, 849, 892, 954, 1162, 1181, 1861, 2086, 2095, 2114, 2136, 2485, 2489, 2603, 2607, 2762, 2942, 3352, 3422, 3581, 3739, 3757, 4020, 4208, 4234, 4260, 4292, 4356], 'Farquhar': [700, 2087, 4252, 4284], 'M.G.': [701, 2088, 4253, 4285], 'Proc.': [702, 843, 886, 1156, 1175, 1855, 2089, 2108, 2130, 2756, 2936, 3575, 3733, 4014, 4202, 4228, 4254, 4286], 'Natl.': [703, 844, 887, 1157, 1176, 1856, 2090, 2109, 2131, 2757, 2937, 3576, 3734, 4015, 4203, 4229, 4255, 4287], 'Acad.': [704, 845, 888, 1158, 1177, 1857, 2091, 2110, 2132, 2758, 2938, 3577, 3735, 4016, 4204, 4230, 4256, 4288], 'U.': [706, 847, 890, 1160, 1179, 1859, 2093, 2112, 2134, 2760, 2940, 3579, 3737, 4018, 4206, 4232, 4258, 4290], 'S.': [707, 848, 891, 906, 956, 1161, 1180, 1860, 2094, 2113, 2123, 2135, 2761, 2941, 3426, 3580, 3738, 3859, 3997, 4019, 4207, 4233, 4259, 4291], '92:': [710, 2097], '11916-11920Crossref': [711, 2098], '(264)': [714, 2101], 'Scholar);': [716], 'induction': [717], 'related': [719, 782], 'messages': [720], 'mitogenic': [722], 'human': [725], 'B': [726, 4036], '(11Newton': [727, 4038], 'J.S.': [728, 4011, 4039], 'Deed': [729, 4040], 'R.W.': [730, 4041], 'Mitchell': [731, 4042], 'E.L.D.': [732, 4043], 'Murphy': [733, 4044], 'J.J.': [734, 4045], 'Norton': [735, 4046], 'J.D.': [736, 3749, 4047], 'Biochim.': [737, 4048], 'Biophys.': [738, 912, 4049], 'Acta.': [739, 4050], '1993;': [740, 758, 4051, 4069], '1216:': [741, 4052], '314-316Crossref': [742, 4053], '(29)': [745, 4056], '12Hong': [748, 4059], 'J.X.': [749, 4060], 'Wilson': [750, 4061], 'G.L.': [751, 4062], 'Fox': [752, 4063], 'C.H.': [753, 4064], 'Kehrl': [754, 826, 1216, 1876, 3615, 3760, 3966, 4065], 'Immunol.': [757, 4068], '150:': [759, 4070], '3895-3904PubMed': [760, 4071], 'T': [764, 4033], '(13Siderovski': [765], 'D.P.': [766, 910, 952, 4075], 'Heximer': [767, 4076], 'S.P.': [768, 4077], 'Forsdyke': [769, 4078], 'D.R.': [770, 4079], 'Mol.': [771, 2155, 3883, 3898, 4080], '1994;': [774, 1797, 1816, 4083], '13:': [775, 4084], '125-147Google': [776, 4085], 'cells;': [778], 'identification': [780], 'sequences': [783], 'data': [785], 'base': [786], 'searches,': [787], 'application': [788], 'polymerase': [790], 'chain': [791, 2268], 'reaction': [792, 1491], 'technology,': [793], 'rescue': [794], 'Sst2p-deficient': [797], 'phenotype,': [798], 'homology-based': [800], 'screening': [801], '14Druey': [820], 'K.M.': [821, 1215, 1875, 3610, 3759, 3961], 'Blumer': [822, 1218, 1878, 3611, 3962], 'K.J.': [823, 1219, 1879, 3612, 3963], 'Kang': [824, 3613, 3964], 'V.H.': [825, 3614, 3965], '379:': [830, 3619, 3970], '742-746Crossref': [831, 3620, 3971], '(404)': [834, 3623, 3974], '15Chen': [837], 'C.K.': [838, 1151, 1850], 'Wieland': [839, 1152, 1851], 'T.': [840, 1153, 1447, 1733, 1852, 1912, 2127, 2755, 2935, 3069, 4390], 'Simon': [841, 1154, 1853, 1915, 3072], '93:': [851, 1164, 1863, 4262, 4294], '12885-12889Crossref': [852, 1165, 1864], '(124)': [855, 1168, 1867], '16Chen': [858], 'C.': [859, 3568, 3726, 3895], 'Zheng': [860], 'B.': [861], 'Han': [862], 'Lin': [864], 'S.-C.': [865], '8679-8685Abstract': [871], '(142)': [879], '17Faurobert': [882, 1171, 2104], 'E.': [883, 1172, 1789, 2105, 4199, 4225, 4247, 4279], 'Hurley': [884, 1173, 2106, 4200, 4226], 'J.B.': [885, 1174, 2107, 4201, 4227], '94:': [894, 1183, 2116, 2138, 2764, 2944, 3583, 3741, 4022, 4210, 4236], '2945-2950Crossref': [895, 1184, 2117, 4211, 4237], '(93)': [898, 1187, 2120, 4214, 4240], '18Snow': [901], 'B.E.': [902], 'Antonio': [903], 'Suggs': [905], 'Gutstein': [907], 'H.B.': [908], 'Siderovski': [909], 'Res.': [913, 1438], 'Commun.': [914], '233:': [916], '770-777Crossref': [917], '(98)': [920], 'These': [923, 1702, 3181, 3314], 'developments': [924], 'reviewed': [927], 'previously': [928], 'others': [930], '(8Dohlman': [931], '19Siderovski': [951], 'Hessel': [953], 'Chung': [955], 'Mak': [957], 'T.W.': [958, 1230], 'Tyers': [959], 'Curr.': [961, 978, 993], '6:': [964], '211-212Abstract': [965], '(175)': [973], '20Neer': [976], '7:': [981, 3902], 'R31-R33Abstract': [982], '21Koelle': [991], 'Opin.': [994], 'Cell': [995], '9:': [998], '143-147Crossref': [999], '(172)': [1002], 'To': [1005, 1268, 3770], 'date,': [1006, 3771], '19': [1007], 'genes': [1009], 'encode': [1013], 'diagnostic': [1018], 'domain': [1021, 2055, 2070, 3411, 4189], '(Fig.': [1022, 2050], '1).': [1023, 2051], 'Typically,': [1024], '120-amino': [1026], 'acid': [1027], 'flanked': [1030], 'sides': [1033], 'highly': [1035], 'variable': [1036], 'arms': [1037], 'constitute': [1039], '25-kDa': [1041], 'However,': [1043, 1134, 1933, 2245, 3153], 'split': [1049], '(observed': [1050], 'only': [1051, 2785, 3508, 3939], 'lower': [1053], 'organisms),': [1054], 'larger': [1056], 'members': [1058, 2672, 2702, 2740, 2795, 3159, 4341, 4527], 'identified': [1061], '(e.g.': [1062, 1501], 'RGS3,': [1063, 3671], 'RGS7).RGS': [1064], 'Proteins': [1065, 2860], 'Are': [1066], 'GAPsGiven': [1068], 'genetic': [1070], 'evidence': [1071, 1129], 'level': [1086], 'dissociated': [1089], 'subunit': [1091, 3040, 3462], 'above': [1093], '(but': [1094], 'below),': [1099], 'obvious': [1102, 3822, 4167], 'hypotheses': [1103], 'might': [1108, 3165, 3376, 3505], 'inhibitors': [1111, 4121], 'dissociation,': [1114], 'blocking': [1115, 3236, 3381], 'activation,': [1118], 'stimulators': [1120], 'activity,': [1123, 4496], 'facilitating': [1124, 1427], 'deactivation.': [1125], 'no': [1128, 4166], 'former': [1132], 'mechanism.': [1133, 3134, 3219], 'eight': [1137], 'examined': [1144, 3367], 'biochemically,': [1145], 'all': [1146, 2072], '(15Chen': [1150, 1849], '22Berman': [1190], 'D.M.': [1191, 1445, 1469, 1731, 2031, 2751, 2931, 3050], 'Wilkie': [1192, 2128, 4386], 'T.M.': [1193, 2129], '86:': [1198], '445-452Abstract': [1199], '(648)': [1207], '23Watson': [1210, 1870], 'Linder': [1212, 1790, 1872], 'M.E.': [1213, 1791, 1873], 'Druey': [1214, 1874, 3758], '383:': [1222, 1239, 1882], '172-175Crossref': [1223, 1883], '(472)': [1226, 1886], '24Hunt': [1229], 'Fields': [1231], 'T.A.': [1232], 'Casey': [1233], 'P.J.': [1234], 'Peralta': [1235], 'E.G.': [1236], '175-177Crossref': [1240], '(306)': [1243], 'Scholar).In': [1245], 'absence': [1247, 1311, 1326], 'receptor,': [1250], 'rate-limiting': [1252, 1287], 'step': [1253, 1288], 'insteady-state': [1254], 'release': [1263], 'product': [1265, 1371, 1431, 1838], '(GDP': [1266], 'dissociation).': [1267], 'examine': [1269], 'effect': [1271, 1375], 'actual': [1277, 1405], 'GTP,': [1280], 'it': [1281, 1291, 2064, 2832, 3154, 3197], 'bypass': [1285], 'accelerate': [1290, 1583], 'substantially.': [1292], 'approach': [1295], 'requires': [1296], 'preparation': [1297], 'substrate,': [1299], 'GTP-Gα,': [1300], 'incubation': [1302], 'Mg2+.': [1313], 'Catalysis': [1314], 'initiated': [1317], 'addition': [1319, 1364], 'Mg2+': [1321], 'presence': [1324, 3511], 'single': [1333, 1578, 2411], 'round': [1334], 'monitored': [1339], 'over': [1340], 'typical': [1342, 2377], 'time': [1343], 'course': [1344], 'seconds': [1346], 'minutes.': [1348], 'Alternatively,': [1349], 'reconstitution': [1350], 'phospholipid': [1361], 'vesicles': [1362], 'permits': [1363], 'agonist': [1368], 'speed': [1370], 'dissociation;': [1372], 'accelerating': [1374], 'GAP': [1378, 1396, 1496, 1555, 1562, 2078, 2296, 2772, 2978, 3133, 3218, 3339, 3499], 'steady-state': [1380, 1549], 'measured.RGS4': [1386], 'readily': [1388], 'expressed': [1389], 'bacteria': [1391], 'purified,': [1393], 'its': [1395, 1428, 2182, 3036], 'studied': [1400], 'extensively.': [1402], 'Whatever': [1403], 'mechanism': [1406, 2979, 3003, 3098, 3325], 'acceleration': [1408], 'hydrolysis,': [1411], 'RGS4': [1415, 1570, 1581, 1626, 1763, 1825, 2013, 2057, 2169, 2231, 2251, 2292, 2867, 2918, 2954, 2967, 2986, 3119, 3138, 3440, 3476, 3558, 4338], 'conceptualized': [1418], 'enzymes,': [1422], 'substrate': [1424, 1836], '(e.g.Gα-GTP)': [1425], 'conversion': [1429], '(Gα-GDP)': [1432], '(25Ross': [1433], 'Recent': [1435], 'Prog.': [1436], 'Horm.': [1437], '50:': [1440], '207-219PubMed': [1441], '26Berman': [1444], 'Kozasa': [1446, 1732, 2126, 2754, 2934], '271:': [1454, 1740], '27209-27212Abstract': [1455, 1741], '(298)': [1463, 1749], '27Nekrasova': [1466], 'E.R.': [1467, 3048], 'Berman': [1468, 2030, 2750, 2930, 3049, 3350], 'Rustandi': [1470, 3051], 'R.R.': [1471, 3052], 'Hamm': [1472, 1811, 3053], 'H.E.': [1473, 1812, 3054], 'Arshavsky': [1476, 3057], 'Biochemistry.': [1478, 3059], '36:': [1480, 3061], '7638-7643Crossref': [1481, 3062], '(52)': [1484, 3065], 'Parameters': [1487], 'characterize': [1489], 'include': [1492], 'pseudosubstrate': [1499], 'Gα-GTPγS),K': [1502], 'm': [1503, 1612], '"substrate"': [1505], 'andV': [1506], 'max': [1507, 1547, 1609], '(estimated': [1508], 'measurement': [1510], 'initial': [1512], 'rates': [1513, 2381], 'varying': [1518], 'Gα-GTP),': [1521], 'pre-steady': [1524], 'cat)': [1531], 'saturating': [1533], 'GAP.': [1537, 1774, 3115], 'exceed': [1544], 'V': [1546], 'turnover': [1550], 'Gα-GTP': [1552], 'if,': [1556], 'example,': [1558, 3557], 'Gα-GDP': [1564], 'slow.': [1566], 'Gαo': [1572, 1631, 1761, 3344], 'Gαt': [1574, 1603, 1629], 'catalytic;': [1576], 'molecule': [1579, 2263], 'multiple': [1588], 'Gα.': [1591, 2911, 3152], 'maximal': [1593, 1682], 'enhancement': [1595], 'estimated': [1597], 'roughly': [1600, 1617, 2640], '100-fold': [1601], '(to': [1604], '0.5/s': [1605], '4': [1607, 2584], '°C).V': [1608], 'K': [1611, 1637], '(at': [1613], '22': [1614], '°C)': [1615], '3/s': [1618], '2': [1620, 2368], 'μm,': [1621], 'respectively;': [1622], 'GTPγS-bound': [1628], 'approximately': [1633], 'equal': [1634], 'm.The': [1638], 'capacities': [1639], 'serve': [1644], 'substrates': [1646], 'influenced': [1652], 'palmitoylation': [1654, 1662, 1708], 'Gα,': [1656, 3485], 'vitro.': [1660], 'Thus,': [1661], 'Gαz': [1664], 'Gαi': [1666, 3342], 'decreased': [1667], 'their': [1668, 1766, 2529, 2653, 2852, 3550, 3795, 4380, 4415, 4502], 'affinities': [1669, 1753, 1977], '90%,': [1677], 'well': [1679, 3837, 4134], '(28Tu': [1687, 1959], 'Y.': [1688, 1960, 2150, 3005, 3627, 3682, 3878, 3999], 'Wang': [1689, 1961], '278:': [1695, 1967], '1132-1135Crossref': [1696, 1968], '(130)': [1699, 1971], 'observations': [1703, 1844, 3027, 4424], 'particularly': [1705], 'intriguing': [1706], 'reversible': [1712], 'and,': [1713, 2399], 'some': [1717, 4177, 4433], 'cases,': [1718], 'response': [1722, 3952, 3989], 'activation': [1724, 2318, 2960, 2991, 3605, 3782, 3954, 4031], 'receptors.Berman': [1727], 'et': [1728, 3259], 'al.': [1729, 3260], '(26Berman': [1730], 'compared': [1752, 2457], 'GTPγS-,': [1755], 'GDP-,': [1756], 'GDP-AlF4−-bound': [1758, 1776], 'forms': [1759, 1777, 3173], 'testing': [1765], 'capacity': [1767], 'compete': [1769, 2906, 2923], 'GTP-Gαo': [1771], 'approximate': [1781], 'transition-state': [1782, 1938, 2522, 3179], '(29Coleman': [1784], 'D.E.': [1785], 'Berghuis': [1786], 'A.M.': [1787], 'Lee': [1788], 'Sprang': [1794, 2034], 'S.R.': [1795, 2035], '265:': [1798], '1405-1412Crossref': [1799], '(749)': [1802], '30Sondek': [1805], 'Lambright': [1807], 'D.G.': [1808], 'Noel': [1809], 'J.P.': [1810, 2152, 3880], 'Sigler': [1813], 'P.B.': [1814], '372:': [1817], '276-279Crossref': [1818], '(532)': [1821], 'Scholar),': [1823, 1973, 3589, 3976, 4268], 'markedly': [1827, 4411], 'higher': [1828], 'than': [1833, 2825, 3177, 4414], 'complexes.': [1839, 2590], 'Others': [1840], 'made': [1842, 3030], 'similar': [1843], 'different': [1846, 2559, 3213], '31Natochin': [1889], 'Granovsky': [1891], 'A.E.': [1892], 'Artemyev': [1893], 'N.O.': [1894], '17444-17449Abstract': [1900], '(49)': [1908], '32Wieland': [1911, 3068], 'Chen': [1913, 2149, 3070, 3877, 3998], 'C.-K.': [1914, 3071], '8853-8856Abstract': [1922, 3079], '(41)': [1930, 3087], 'preferential': [1934, 3167], 'always': [1942], 'manifest.': [1943], 'A': [1944], 'designated': [1946, 2678], 'Gz': [1947], 'member': [1954], 'equally': [1975], 'GTPγS-Gαz': [1980], 'GDP-AlF4−-Gαz': [1982], '(33Wang': [1983], 'Tu': [1985], 'Y.P.': [1986], 'Woodson': [1987], 'Song': [1989, 2151, 3879], 'X.L.': [1990], '5732-5740Abstract': [1998], '(65)': [2006], 'Scholar).The': [2008], 'between': [2012, 2917, 3359, 4128, 4515], 'Gαi1-GDP-AlF4−permitted': [2015], 'crystallization': [2016], 'solution': [2018], 'structure': [2021, 3392, 3435], '2.8-Å': [2026], 'resolution': [2027], '(34Tesmer': [2028], 'J.J.G.': [2029], '89:': [2038], '251-261Abstract': [2039], '(680)': [2047], 'Only': [2052, 4456], 'was': [2058, 4304], 'visible': [2059], 'crystal.': [2062], 'Importantly,': [2063], 'demonstrated': [2067, 3283, 4395], 'contains': [2071, 2170, 4186], 'crucial': [2075], 'Scholar,35Popov': [2122], 'Yu': [2124], 'K.': [2125, 2477, 2595, 3420, 4353], '7216-7220Crossref': [2139], '(148)': [2142], '36Dohlman': [2145], 'Apaniesk': [2147, 3875], 'D.': [2148, 2154, 3876, 3882], 'Nusskern': [2153, 3881], '15:': [2159, 3887], '3635-3643Crossref': [2160, 3888], '(166)': [2163, 3891], 'classic': [2172], 'right-handed,': [2173], 'antiparallel': [2174], 'four-helix': [2175], 'bundle': [2176], 'interacts': [2178, 4310], '(via': [2179], 'loops': [2180], 'along': [2181], 'base)': [2183], 'switches': [2185, 2193, 2218, 2505, 2877], 'I,': [2186], 'II,': [2187], 'III': [2189], 'Gαi1.': [2191, 2459, 2874], 'those': [2198, 2309, 2349, 3215], 'regions': [2199, 2302, 2872], 'conformations': [2201, 2307], 'sensitive': [2203], 'identity': [2206], 'bound': [2209], '(GTP': [2211], 'GDP),': [2213], 'residues': [2216, 2236, 2542, 2552], 'I': [2219], 'II': [2221, 3483], 'intimately': [2223], 'involved': [2224, 2880], 'GTP.': [2230], 'does': [2232, 2845, 2968], 'contribute': [2234, 2324], 'any': [2235, 2849], 'interact': [2238, 2254, 2886, 3200, 4347], 'directly': [2239, 2427, 2462, 4348], 'either': [2241], 'AlF4−.': [2244], 'conserved': [2247], 'Asn': [2248], 'residue': [2249, 2271, 2275, 2413, 2448], '(Asn128)': [2252], 'ground': [2257], 'hydrolytic': [2261], 'water': [2262, 2282, 2333], 'side': [2267], 'Gαi1': [2270, 2425, 3437], 'Gln204,': [2272], 'orients': [2277], 'polarizes': [2279], 'catalytic': [2281, 3410, 3525], 'transition': [2285, 2313, 2442], 'state.': [2286, 2443], 'thus': [2289, 2315, 3327], 'suggested': [2290], 'acts': [2293], 'stabilizing': [2298], 'flexible': [2300], 'switch': [2301, 2871, 3482], 'resembling': [2308, 2851], 'found': [2310], 'state,': [2314], 'lowering': [2316], 'energy': [2319], 'barrier;': [2320], 'Asn128': [2321], 'further': [2323], 'chemistry': [2327], 'Gln204.Comparison': [2335], 'RasGAPComparisons': [2337], 'structures': [2342, 2523, 3487], 'continue': [2354], 'useful.': [2357], 'basal': [2359, 2397], 'catalyzed': [2364, 2374], 'Ras': [2366, 2444, 2525], 'orders': [2369], 'magnitude': [2371], 'below': [2372], 'GAP-stimulated': [2383], 'similar.': [2390, 2534], 'Much': [2391], 'difference': [2394], 'thus,': [2400], 'correspondingly': [2402], 'greater': [2403, 2819], 'efficiency': [2404], 'RasGAP': [2406, 2460, 2499], 'ascribable': [2408], 'Arg': [2412, 2539, 2551], 'active': [2416, 2474, 2518, 2556, 2576, 3114], 'site': [2417, 2475, 2557], 'Arg178': [2423], 'participates': [2426, 2461], 'catalysis': [2429], 'stabilization': [2431], 'charge': [2435], 'γ-phosphoryl': [2437], 'oxygen': [2438], 'atoms': [2439], 'lacks': [2445], 'essentially': [2451], 'when': [2456, 4406, 4419], 'insertion': [2467, 4197], '"arginine': [2470], 'finger"': [2471], 'into': [2472, 2554], '(37Scheffzek': [2476], 'Ahmadian': [2478, 2596], 'Kabsch': [2480, 2598], 'W.': [2481, 2599], 'Wiesmuller': [2482, 2600], 'Lautwein': [2484, 2602], 'Schmitz': [2486, 2604], 'Wittinghofer': [2488, 2606], '277:': [2492, 2610], '333-338Crossref': [2493, 2611], '(1181)': [2496, 2614], 'also': [2500, 2735, 2879, 2998, 4101], 'binds': [2501, 2868], 'mobile': [2504], 'Ras,': [2507], 'orienting': [2508], 'Gln61': [2509], 'appropriately': [2510], '(Gln61': [2511], 'corresponds': [2512], 'Gln204': [2514], 'Gαi1).': [2516], 'Gαi1(associated': [2527], 'respective': [2530], 'GAPs)': [2531], 'amazingly': [2533], 'In': [2535, 2951], 'particular,': [2536], 'Gln': [2541], 'nearly': [2545], 'identical': [2546], 'positions,': [2547], 'even': [2548], 'though': [2549], 'directions,': [2560], '(Gαi1)': [2563], 'contributed': [2565], 'cis,': [2567], 'other': [2569, 3158, 3245, 3982, 4340, 4519], 'trans': [2571], '(Fig.2).Figure': [2572], '2Superposition': [2573], 'i': [2581], '1': [2582], '-GDP-AlF': [2583], '−': [2585], '(blue)': [2586], 'Ras-GDP-AlF3-GAP334': [2588], '(orange/red)': [2589], 'Reproduced': [2591], '37Scheffzek': [2594], 'permission.View': [2618], 'Large': [2619], 'Image': [2620], 'Figure': [2621], 'ViewerDownload': [2622], 'Hi-res': [2623], 'image': [2624], 'Download': [2625], '(PPT)Specificity': [2626], 'RGS-Gα': [2628, 2822], 'InteractionsEarly': [2629], 'large': [2633, 2840, 4319], 'comparable': [2641], 'subunits,': [2646], 'prompted': [2647], 'speculation': [2648], 'specificity': [2651, 2820, 4090], 'interactions;': [2654], 'realized': [2659], 'extent': [2662, 3597], 'anticipated.': [2663], 'usually': [2669], 'categorized': [2670], 'four': [2676], 'subfamilies,': [2677], 'Gs': [2679], '(two': [2680, 2690], 'genes),': [2681, 2684, 2687], 'Gi': [2682, 2705, 2714], '(eight': [2683], 'Gq': [2685, 2743], '(four': [2686], 'G12': [2689], 'genes).': [2691], 'Most': [2692], 'tested': [2695, 2783, 3333, 4407, 4420], 'date': [2697], 'toward': [2701, 2739, 3341], 'subfamily': [2706, 2744, 2794], 'appear': [2708, 4345], 'discriminate': [2710], 'minimally': [2711], 'among': [2712], 'them;': [2713], 'K+': [2720], 'channels,': [2721, 2724], 'Ca2+': [2723], 'phosphodiesterases.': [2729], 'Some': [2730], '(phospholipase': [2745], 'Cβ': [2746, 2963], 'activators)': [2747], '(38Hepler': [2748, 2928], '428-432Crossref': [2765, 2945], '(335)': [2768, 2948], 'Because': [2771, 2966], 'assays': [2773], 'Gαq': [2775], 'technically,': [2778], 'few': [2787], 'cases.': [2788], 'Gαs': [2791, 3362, 3385, 3407, 3444], 'Gα12': [2793], 'detected,': [2799], 'although': [2800], 'inhibitory': [2801], 'effects': [2802], 'Gs-mediated': [2807], 'observed': [2812, 2916], '(see': [2813], 'below).': [2814], 'suspect': [2817, 4523], 'currently': [2827], 'evident': [2828], 'will': [2829, 3914, 4156, 4472, 4480, 4509, 4513], 'uncovered,': [2831], 'seems': [2833], 'clear': [2834], 'explanation': [2837], 'lie': [2847], 'scenario': [2850], '1:1': [2853], 'correspondence': [2854], 'subunits.RGS': [2859], 'May': [2861], 'Be': [2862], 'Effector': [2863], 'AntagonistsAs': [2864], 'noted': [2865, 3987], 'above,': [2866], 'Logically,': [2875], 'effector': [2882, 2908, 3091, 3189, 3400], 'binding,': [2883], 'preferentially': [2887], 'GTP-bound': [2889, 4376], 'proximity': [2893], 'overlap': [2895], 'surfaces': [2898], 'raises': [2899], 'possibility': [2901, 3371], 'Such': [2912, 3832], 'competition': [2913], 'phospholipase': [2920, 2962], 'Cβ,': [2921], 'which': [2922, 3111, 4400], 'GTPγS-Gαq': [2927], 'addition,': [2952], 'GAIP': [2956, 3560, 3674, 4217, 4270], 'prevent': [2957, 3149], 'pertussis': [2958], 'toxin-insensitive': [2959], 'GTPγS.': [2965], 'stimulate': [2970], 'GTPγS': [2973], 'cannot': [2980], 'operative.': [2982], 'Transient': [2983], 'expression': [2984, 3285, 3991], 'COS-7': [2988], 'blocked': [2990], 'inositol': [2993, 3679], 'phosphate': [2994], 'AlF4−,': [2997], 'consistent': [2999], 'effector-antagonist': [3002], '(39Yan': [3004, 3681], 'Chi': [3006, 3628, 3683], 'P.P.': [3007, 3629, 3684], 'Bourne': [3008, 3630, 3685], '11924-11927Abstract': [3015, 3637, 3692], '(126)': [3023, 3645, 3700], 'Similar': [3026], 'Gαt,': [3034], 'effector,': [3037], 'retinal': [3043], 'GMP': [3045], 'phosphodiesterase': [3046], '(27Nekrasova': [3047], 'Scholar).Competition': [3089], 'would': [3093, 3209, 3248, 3254, 3463], 'effective': [3097, 4413], 'protein-mediated': [3104], 'like': [3109], 'RGS4,': [3110, 3592, 3672], 'itself': [3126, 3866], 'sufficient': [3127], 'interrupt': [3129], 'via': [3131], 'GDP-bound': [3140, 3172], 'presumably': [3146, 3317], 'insufficient': [3147], 'recycling': [3150], 'GTP-': [3170], 'rather': [3176], 'complex.': [3180], 'could': [3183, 3198, 3493], 'then,': [3184], 'theory,': [3186], 'antagonists': [3190], 'sequestrants': [3192], 'Either': [3205], 'mechanisms': [3208, 3247], 'consequences': [3211, 4109], 'substantially': [3212], 'Simple': [3220], 'stimulation': [3221, 3299], 'deactivates': [3228], 'facilitates': [3232], 'association': [3233], 'βγ,': [3235], 'two': [3246, 3491], 'block': [3249, 3465, 3561], 'but': [3253, 3345, 3928, 4176], 'leave': [3255], 'βγ-mediated': [3256], 'intact.Chatterjee': [3258], '(40Chatterjee': [3261], 'T.K.': [3262, 3649, 3704], 'Eapen': [3263, 3650, 3705], 'A.K.': [3264, 3651, 3706], 'Fisher': [3265, 3652, 3707], 'R.A.': [3266, 3653, 3708], '15481-15487Abstract': [3272, 3659, 3714], '(114)': [3280, 3667, 3722], 'truncated': [3288], 'form': [3289], 'RGS3': [3291], '(RGS3T)': [3292], 'baby': [3294], 'hamster': [3295], 'kidney': [3296], 'impaired': [3298], 'AMP': [3302], 'accumulation': [3303], 'calcitonin': [3306], 'gene-related': [3307], 'peptide': [3308], 'pituitary': [3310], 'cyclase-activating': [3312], 'peptide.': [3313], 'peptides': [3315], 'activating': [3318], 'Gs-coupled': [3319], 'receptors,': [3320], 'question': [3323], 'considerable': [3329], 'interest.': [3330], 'We': [3331, 4522], 'RGS3T': [3334, 3360], 'vitro': [3336, 3553], 'detected': [3338], 'Gαs.': [3347], '2D.': [3348], 'Gilman,': [3354, 3424, 4358], 'unpublished': [3355, 4359], 'observation.': [3356], 'Direct': [3357], 'yet': [3365, 3807], 'evaluate': [3369], 'antagonist,': [3380], 'cyclase.': [3388, 3414, 3473], 'crystal': [3391], 'associated': [3397, 3438, 3445], 'solved,': [3404], '3J.': [3415], 'Tesmer,': [3418], 'R.': [3419, 3427, 4003], 'Sunahara,': [3421], 'Sprang,': [3428], 'manuscript': [3429], 'preparation.': [3431], 'Superposition': [3432], 'cyclase': [3448, 3479, 3566, 3785], 'suggests': [3449], 'bind': [3480, 4364], 'suggest': [3488], 'accommodated': [3495], 'simultaneously.': [3496], 'Speculatively,': [3497], 'manifest': [3507], 'ancillary': [3513], 'molecules,': [3514], 'effector.Regulation': [3518], 'ProteinsRGS': [3521], 'voracious': [3524], 'appetites.': [3526], 'Their': [3527], 'overexpression': [3528], 'various': [3530, 4526], 'cultured': [3531], 'demonstrates': [3533], 'they': [3535, 4445, 4471], 'capable': [3537], 'barbarians,': [3538], 'general': [3540], 'obliterating': [3541], 'manners': [3547], 'predictable': [3548], 'specificities': [3551, 4500], 'For': [3556], 'Gi-mediated': [3562], 'inhibition': [3563], '(41Huang': [3567], 'Hepler': [3569, 3727], 'Mumby': [3573, 3731], 'S.M.': [3574, 3732], '6159-6163Crossref': [3584, 3742], '(150)': [3587, 3745], 'whereas': [3590, 3977], 'RGS3T,': [3591, 3787], 'lesser': [3596], 'RGS1': [3598], 'RGS2': [3600], 'attenuate': [3601], 'Gq-': [3602], 'Gi-regulated': [3604], 'MAP': [3607], 'kinase': [3608], '(14Druey': [3609, 3960], '39Yan': [3626], '40Chatterjee': [3648, 3703], 'Similarly,': [3670], 'suppress': [3675], 'Gαq-mediated': [3676], 'trisphosphate': [3680], '41Huang': [3725], '42Neill': [3748], 'Duck': [3750], 'L.W.': [3751], 'Sellers': [3752], 'J.C.': [3753], 'Musgrove': [3754], 'L.C.': [3755], 'Scheschonka': [3756], 'Endocrinology.': [3762], '137:': [3764], '843-846Crossref': [3765], '(88)': [3767], 'unanticipated': [3773], 'studies': [3777], 'attenuation': [3779], 'receptor-mediated': [3781], 'discussed': [3788], 'above.The': [3789], 'dictates': [3794, 4102], 'scrupulous': [3796], 'cells.': [3799], 'know': [3808], 'how': [3809], 'vivo': [3815], 'what': [3818], 'purpose.': [3819], 'paradigm': [3823, 3933], 'involves': [3824], 'feedback': [3825, 4120], 'desensitization': [3826, 3833], 'activated,': [3828], 'pathways.': [3831], 'is,': [3834], 'course,': [3836], 'systems,': [3842, 4130], 'exerted': [3846], 'many': [3848, 4095], 'levels.': [3849], 'characterized,': [3856], 'Sst2p': [3857], 'cerevisiae,': [3860], 'fills': [3861], 'role': [3863], 'control': [3869], 'gene': [3871, 3950], 'transcription': [3872, 3944, 3980], '(36Dohlman': [3873], '43Dietzel': [3894], 'Kurjan': [3896], '4169-4177Crossref': [3903], '(160)': [3906], 'likely': [3911], 'part': [3919], 'story': [3924], 'broad': [3929, 4089], 'adoption': [3930], 'premature.': [3935], 'example': [3941], 'enhanced': [3943], 'p53': [3993], '(44Buckbinder': [3994], 'Velasco-Miguel': [3996], 'Xu': [4000], 'Talbott': [4002], 'Gelbert': [4004], 'Gao': [4006], 'Seizinger': [4008], 'B.R.': [4009], 'Gutkind': [4010], 'Kley': [4012], '7868-7872Crossref': [4023], '(84)': [4026], 'polyclonal': [4030], '13Siderovski': [4074], 'apparently': [4088], 'caution': [4103], 'interpretation': [4105], 'physiological': [4108], 'action.': [4113], 'Will': [4114], 'predominantly': [4118], 'pathways,': [4124], 'transducers': [4125], 'cross-talk': [4127], 'both?Even': [4132], 'less': [4133, 4412], 'potential': [4137], 'roles': [4138], 'subcellular': [4140], 'localization': [4141, 4171], 'posttranslational': [4143], 'modification': [4144], 'function.': [4150], 'indications': [4153], 'fruitful': [4158], 'areas': [4159], 'experimentation.': [4161], 'Many': [4162], 'motifs': [4168], 'specify': [4170], 'action,': [4175, 4370], 'suggestions': [4182], 'others.': [4184], 'Ret-RGS1': [4185, 4219], 'hydrophobic': [4188], 'near': [4190, 4478], 'amino': [4192], 'terminus': [4193], 'suggestive': [4194], 'transmembrane': [4196], '(17Faurobert': [4198, 4224], 'cysteine': [4222], 'string': [4223], '45De': [4243], 'Elenko': [4246, 4278], 'Hubler': [4248, 4280], 'Jones': [4250, 4282], 'T.L.Z.': [4251, 4283], '15203-15208Crossref': [4263, 4295], '(156)': [4266, 4298], 'palmitoylated': [4272], 'membrane-bound': [4274], '(45De': [4275], 'partner': [4308], 'carboxyl-terminal': [4313], 'cytoplasmic': [4314], 'tail': [4315], 'polycystin,': [4317], 'integral': [4320], 'membrane': [4321], 'unknown': [4324], 'function': [4325], 'implicated': [4326], 'genesis': [4329], 'polycystic': [4331], 'renal': [4332], 'disease.': [4333], '4G.': [4334], 'Walz,': [4335], 'personal': [4336, 4392], 'communication.': [4337, 4393], 'cyclases.': [4351], '5R.': [4352], 'Sunahara': [4354], 'observations.': [4360], 'Perhaps': [4361], 'deactivate': [4375], 'after': [4379], 'Muallem': [4384, 4388], '6S.': [4387], 'Wilkie,': [4391], 'boxes,': [4399], 'retain': [4401], 'full': [4402], 'potency': [4403], 'efficacy': [4405], 'vitro,': [4409], 'full-length,': [4416], '"armed"': [4417], 'counterparts': [4418], 'vivo.Although': [4422], 'mentioned': [4425], 'briefly': [4426], 'previous': [4429], 'paragraph': [4430], 'ways': [4434], 'disjointed': [4435], 'several': [4437], 'them': [4439], 'quite': [4441], 'preliminary,': [4442], 'believe': [4444, 4470], 'speak': [4446], 'exciting': [4449], 'future': [4450, 4479], 'research': [4452], 'area.': [4455], 'simplistic': [4457], 'models': [4458], 'action': [4462], 'drawn': [4465], '(Fig.3),': [4467], 'proven': [4474], 'entirely': [4475], 'inadequate.': [4476], 'almost': [4481], 'certainly': [4482], 'yield': [4483], 'great': [4485], 'deal': [4486], 'new': [4488], 'about': [4490], 'concentration,': [4495], 'localization.': [4498], 'constituents.': [4521], 'fam': [4530]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2050307742', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 8}, {'year': 2015, 'cited_by_count': 10}, {'year': 2014, 'cited_by_count': 9}, {'year': 2013, 'cited_by_count': 8}, {'year': 2012, 'cited_by_count': 9}], 'updated_date': '2025-01-08T02:41:15.853675', 'created_date': '2016-06-24'}
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