Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2050200152', 'doi': 'https://doi.org/10.1111/j.1600-0609.2004.00356.x', 'title': 'Clinical correlates of submicroscopic deletions involving the <i>ABL</i>–<i>BCR</i> translocation region in chronic myeloid leukemia', 'display_name': 'Clinical correlates of submicroscopic deletions involving the <i>ABL</i>–<i>BCR</i> translocation region in chronic myeloid leukemia', 'publication_year': 2005, 'publication_date': '2005-01-11', 'ids': {'openalex': 'https://openalex.org/W2050200152', 'doi': 'https://doi.org/10.1111/j.1600-0609.2004.00356.x', 'mag': '2050200152', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/15654903'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/j.1600-0609.2004.00356.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S159715054', 'display_name': 'European Journal Of Haematology', 'issn_l': '0902-4441', 'issn': ['0902-4441', '1600-0609'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5043229426', 'display_name': 'Yinlee Yoong', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Yinlee Yoong', 'raw_affiliation_strings': ['Division of Hematology, Department of Internal Medicine'], 'affiliations': [{'raw_affiliation_string': 'Division of Hematology, Department of Internal Medicine', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5060458477', 'display_name': 'Todd J. VanDeWalker', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210125099', 'display_name': 'Mayo Clinic in Arizona', 'ror': 'https://ror.org/03jp40720', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723', 'https://openalex.org/I4210125099']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Todd J. VanDeWalker', 'raw_affiliation_strings': ['Laboratory of Cytogenetics, Mayo Clinic, Rochester, MN, USA'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Cytogenetics, Mayo Clinic, Rochester, MN, USA', 'institution_ids': ['https://openalex.org/I4210125099']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035605122', 'display_name': 'Richard O. Carlson', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210125099', 'display_name': 'Mayo Clinic in Arizona', 'ror': 'https://ror.org/03jp40720', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723', 'https://openalex.org/I4210125099']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Richard O. Carlson', 'raw_affiliation_strings': ['Laboratory of Cytogenetics, Mayo Clinic, Rochester, MN, USA'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Cytogenetics, Mayo Clinic, Rochester, MN, USA', 'institution_ids': ['https://openalex.org/I4210125099']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113542194', 'display_name': 'Gordon W. Dewald', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210125099', 'display_name': 'Mayo Clinic in Arizona', 'ror': 'https://ror.org/03jp40720', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723', 'https://openalex.org/I4210125099']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Gordon W. Dewald', 'raw_affiliation_strings': ['Laboratory of Cytogenetics, Mayo Clinic, Rochester, MN, USA'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Cytogenetics, Mayo Clinic, Rochester, MN, USA', 'institution_ids': ['https://openalex.org/I4210125099']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5016216479', 'display_name': 'Ayalew Tefferi', 'orcid': 'https://orcid.org/0000-0003-4605-3821'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Ayalew Tefferi', 'raw_affiliation_strings': ['Division of Hematology, Department of Internal Medicine'], 'affiliations': [{'raw_affiliation_string': 'Division of Hematology, Department of Internal Medicine', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4220, 'currency': 'USD', 'value_usd': 4220, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 2.775, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 32, 'citation_normalized_percentile': {'value': 0.728036, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 90, 'max': 91}, 'biblio': {'volume': '74', 'issue': '2', 'first_page': '124', 'last_page': '127'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11215', 'display_name': 'Chronic Myeloid Leukemia Treatments', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11215', 'display_name': 'Chronic Myeloid Leukemia Treatments', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11157', 'display_name': 'Chronic Lymphocytic Leukemia Research', 'score': 0.9978, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12600', 'display_name': 'Eosinophilic Disorders and Syndromes', 'score': 0.9954, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/breakpoint-cluster-region', 'display_name': 'breakpoint cluster region', 'score': 0.58060586}, {'id': 'https://openalex.org/keywords/philadelphia-chromosome', 'display_name': 'Philadelphia chromosome', 'score': 0.49769405}, {'id': 'https://openalex.org/keywords/abl', 'display_name': 'ABL', 'score': 0.41687015}], 'concepts': [{'id': 'https://openalex.org/C2778729363', 'wikidata': 'https://www.wikidata.org/wiki/Q11688946', 'display_name': 'Myeloid leukemia', 'level': 2, 'score': 0.760309}, {'id': 'https://openalex.org/C138626823', 'wikidata': 'https://www.wikidata.org/wiki/Q916504', 'display_name': 'Chromosomal translocation', 'level': 3, 'score': 0.6143068}, {'id': 'https://openalex.org/C61511704', 'wikidata': 'https://www.wikidata.org/wiki/Q1671857', 'display_name': 'Incidence (geometry)', 'level': 2, 'score': 0.5925842}, {'id': 'https://openalex.org/C43907098', 'wikidata': 'https://www.wikidata.org/wiki/Q903924', 'display_name': 'breakpoint cluster region', 'level': 3, 'score': 0.58060586}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.53095955}, {'id': 'https://openalex.org/C2779282312', 'wikidata': 'https://www.wikidata.org/wiki/Q1956561', 'display_name': 'Myeloid', 'level': 2, 'score': 0.51485914}, {'id': 'https://openalex.org/C2778904597', 'wikidata': 'https://www.wikidata.org/wiki/Q1129111', 'display_name': 'Philadelphia chromosome', 'level': 4, 'score': 0.49769405}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.48164144}, {'id': 'https://openalex.org/C90924648', 'wikidata': 'https://www.wikidata.org/wiki/Q120569', 'display_name': 'Gastroenterology', 'level': 1, 'score': 0.46883053}, {'id': 'https://openalex.org/C53226629', 'wikidata': 'https://www.wikidata.org/wiki/Q189967', 'display_name': 'Karyotype', 'level': 4, 'score': 0.46534455}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.43298262}, {'id': 'https://openalex.org/C167135981', 'wikidata': 'https://www.wikidata.org/wiki/Q2146302', 'display_name': 'Retrospective cohort study', 'level': 2, 'score': 0.4296925}, {'id': 'https://openalex.org/C72563966', 'wikidata': 'https://www.wikidata.org/wiki/Q1303415', 'display_name': 'Cohort', 'level': 2, 'score': 0.42090943}, {'id': 'https://openalex.org/C125418893', 'wikidata': 'https://www.wikidata.org/wiki/Q587961', 'display_name': 'ABL', 'level': 4, 'score': 0.41687015}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.35112375}, {'id': 'https://openalex.org/C30481170', 'wikidata': 'https://www.wikidata.org/wiki/Q37748', 'display_name': 'Chromosome', 'level': 3, 'score': 0.27015558}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.12830877}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.085035354}, {'id': 'https://openalex.org/C121332964', 'wikidata': 'https://www.wikidata.org/wiki/Q413', 'display_name': 'Physics', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C120665830', 'wikidata': 'https://www.wikidata.org/wiki/Q14620', 'display_name': 'Optics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C42362537', 'wikidata': 'https://www.wikidata.org/wiki/Q87099740', 'display_name': 'Tyrosine kinase', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D002899', 'descriptor_name': 'Chromosomes, Human, Pair 9', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D016044', 'descriptor_name': 'Fusion Proteins, bcr-abl', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D015464', 'descriptor_name': 'Leukemia, Myelogenous, Chronic, BCR-ABL Positive', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D017384', 'descriptor_name': 'Sequence Deletion', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002899', 'descriptor_name': 'Chromosomes, Human, Pair 9', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018572', 'descriptor_name': 'Disease-Free Survival', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016044', 'descriptor_name': 'Fusion Proteins, bcr-abl', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017404', 'descriptor_name': 'In Situ Hybridization, Fluorescence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016898', 'descriptor_name': 'Interferon-alpha', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016898', 'descriptor_name': 'Interferon-alpha', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D007621', 'descriptor_name': 'Karyotyping', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015464', 'descriptor_name': 'Leukemia, Myelogenous, Chronic, BCR-ABL Positive', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015464', 'descriptor_name': 'Leukemia, Myelogenous, Chronic, BCR-ABL Positive', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D015464', 'descriptor_name': 'Leukemia, Myelogenous, Chronic, BCR-ABL Positive', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D007958', 'descriptor_name': 'Leukocyte Count', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009929', 'descriptor_name': 'Organ Size', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010976', 'descriptor_name': 'Platelet Count', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011379', 'descriptor_name': 'Prognosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017384', 'descriptor_name': 'Sequence Deletion', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013154', 'descriptor_name': 'Spleen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013154', 'descriptor_name': 'Spleen', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/j.1600-0609.2004.00356.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S159715054', 'display_name': 'European Journal Of Haematology', 'issn_l': '0902-4441', 'issn': ['0902-4441', '1600-0609'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/15654903', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.73, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 15, 'referenced_works': ['https://openalex.org/W114795016', 'https://openalex.org/W1780815163', 'https://openalex.org/W1799579309', 'https://openalex.org/W2029305438', 'https://openalex.org/W2041200806', 'https://openalex.org/W2085358525', 'https://openalex.org/W2098174216', 'https://openalex.org/W2127016965', 'https://openalex.org/W2128974029', 'https://openalex.org/W2155373892', 'https://openalex.org/W2175322229', 'https://openalex.org/W2207680991', 'https://openalex.org/W2210638970', 'https://openalex.org/W2587781815', 'https://openalex.org/W3026292011'], 'related_works': ['https://openalex.org/W834754005', 'https://openalex.org/W4298393597', 'https://openalex.org/W4254255894', 'https://openalex.org/W2407613168', 'https://openalex.org/W2387423610', 'https://openalex.org/W2090592814', 'https://openalex.org/W2080731390', 'https://openalex.org/W2020954035', 'https://openalex.org/W1993703063', 'https://openalex.org/W107386718'], 'abstract_inverted_index': {'Recent': [0], 'reports': [1, 129], 'indicate': [2], 'a': [3, 30, 49, 101], 'prognostically': [4], 'detrimental': [5], 'effect': [6], 'of': [7, 18, 33, 40, 104, 109], 'submicroscopic': [8], 'abl-bcr': [9], 'deletions': [10], 'associated': [11], 'with': [12, 36, 48, 91], 'the': [13, 19, 38, 107, 120], 'break': [14], 'and': [15, 62, 70, 96, 115], 'fusion': [16], 'points': [17], 'derivative': [20], 'chromosome': [21], '9': [22], '[der(9)]': [23], 'in': [24, 59, 74, 143], 'chronic': [25], 'myeloid': [26], 'leukemia': [27], '(CML).': [28], 'In': [29], 'retrospective': [31], 'cohort': [32], '92': [34], 'patients': [35, 61, 89, 145], 'CML,': [37], 'incidence': [39, 108], 'an': [41], 'atypical': [42], 'D-FISH': [43], 'pattern,': [44], 'that': [45, 130], 'is': [46], 'consistent': [47], 'der(9)': [50, 147], 'deletion': [51], 'was': [52, 57], '20%.': [53], 'Complete': [54], 'clinical': [55], 'information': [56], 'available': [58], '82': [60], 'revealed': [63], 'no': [64], 'significant': [65], 'differences': [66], 'between': [67, 119], '18': [68], 'deleted': [69], '64': [71], 'non-deleted': [72], 'cases': [73], 'platelet': [75], 'count,': [76], 'circulating': [77], 'blast': [78], 'percentage,': [79], 'spleen': [80], 'size,': [81], 'or': [82], 'karyotype': [83], 'profile': [84], 'at': [85], 'presentation.': [86], 'However,': [87], 'der(9)-deleted': [88], 'presented': [90], 'significantly': [92], 'lower': [93], 'hemoglobin': [94], 'levels': [95], 'higher': [97], 'leukocyte': [98], 'counts.': [99], 'At': [100], 'median': [102], 'follow-up': [103], '31': [105], 'months,': [106], 'disease': [110], 'transformation,': [111], 'drug': [112], 'therapy': [113, 142], 'response,': [114], 'survival': [116, 133], 'were': [117], 'similar': [118], 'two': [121], 'groups.': [122], 'These': [123], 'results': [124], 'are': [125], 'contrary': [126], 'to': [127, 139], 'previous': [128], 'suggested': [131], 'inferior': [132], 'as': [134, 136], 'well': [135], 'poor': [137], 'response': [138], 'alpha': [140], 'interferon': [141], 'CML': [144], 'carrying': [146], 'deletions.': [148]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2050200152', 'counts_by_year': [{'year': 2020, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}], 'updated_date': '2024-12-16T22:55:12.610427', 'created_date': '2016-06-24'}