Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2050158045', 'doi': 'https://doi.org/10.1155/2010/207835', 'title': 'A New Perspective on Intercalated Disc Organization: Implications for Heart Disease', 'display_name': 'A New Perspective on Intercalated Disc Organization: Implications for Heart Disease', 'publication_year': 2010, 'publication_date': '2010-01-01', 'ids': {'openalex': 'https://openalex.org/W2050158045', 'doi': 'https://doi.org/10.1155/2010/207835', 'mag': '2050158045', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/20585598', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2879923'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1155/2010/207835', 'pdf_url': 'https://downloads.hindawi.com/journals/drp/2010/207835.pdf', 'source': {'id': 'https://openalex.org/S102744128', 'display_name': 'Dermatology Research and Practice', 'issn_l': '1687-6105', 'issn': ['1687-6105', '1687-6113'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319869', 'host_organization_name': 'Hindawi Publishing Corporation', 'host_organization_lineage': ['https://openalex.org/P4310319869'], 'host_organization_lineage_names': ['Hindawi Publishing Corporation'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://downloads.hindawi.com/journals/drp/2010/207835.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5069170925', 'display_name': 'Jifen Li', 'orcid': 'https://orcid.org/0000-0001-8626-7707'}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jifen Li', 'raw_affiliation_strings': ['Department of Medicine, Center for Translational Medicine, Jefferson Medical College, Philadelphia, PA 19107, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, Center for Translational Medicine, Jefferson Medical College, Philadelphia, PA 19107, USA.', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5008805727', 'display_name': 'Glenn L. Radice', 'orcid': 'https://orcid.org/0000-0002-2944-1059'}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Glenn L. Radice', 'raw_affiliation_strings': ['Department of Medicine, Center for Translational Medicine, Jefferson Medical College, Philadelphia, PA 19107, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, Center for Translational Medicine, Jefferson Medical College, Philadelphia, PA 19107, USA.', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 900, 'currency': 'USD', 'value_usd': 900, 'provenance': 'doaj'}, 'apc_paid': {'value': 900, 'currency': 'USD', 'value_usd': 900, 'provenance': 'doaj'}, 'fwci': 3.796, 'has_fulltext': False, 'cited_by_count': 51, 'citation_normalized_percentile': {'value': 0.920452, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '2010', 'issue': '1', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11922', 'display_name': 'Cardiovascular Effects of Exercise', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11922', 'display_name': 'Cardiovascular Effects of Exercise', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11246', 'display_name': 'Sports injuries and prevention', 'score': 0.994, 'subfield': {'id': 'https://openalex.org/subfields/2732', 'display_name': 'Orthopedics and Sports Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13354', 'display_name': 'Genetics and Physical Performance', 'score': 0.9607, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/adherens-junction', 'display_name': 'Adherens junction', 'score': 0.97852886}, {'id': 'https://openalex.org/keywords/plakoglobin', 'display_name': 'Plakoglobin', 'score': 0.9647501}, {'id': 'https://openalex.org/keywords/desmoplakin', 'display_name': 'Desmoplakin', 'score': 0.9560081}, {'id': 'https://openalex.org/keywords/desmosome', 'display_name': 'Desmosome', 'score': 0.9042235}, {'id': 'https://openalex.org/keywords/intercalated-disc', 'display_name': 'Intercalated disc', 'score': 0.7438082}], 'concepts': [{'id': 'https://openalex.org/C201508349', 'wikidata': 'https://www.wikidata.org/wiki/Q45173', 'display_name': 'Adherens junction', 'level': 4, 'score': 0.97852886}, {'id': 'https://openalex.org/C48220470', 'wikidata': 'https://www.wikidata.org/wiki/Q21139990', 'display_name': 'Plakoglobin', 'level': 5, 'score': 0.9647501}, {'id': 'https://openalex.org/C2777189754', 'wikidata': 'https://www.wikidata.org/wiki/Q5264821', 'display_name': 'Desmoplakin', 'level': 3, 'score': 0.9560081}, {'id': 'https://openalex.org/C2778757060', 'wikidata': 'https://www.wikidata.org/wiki/Q846957', 'display_name': 'Desmosome', 'level': 3, 'score': 0.9042235}, {'id': 'https://openalex.org/C2781175142', 'wikidata': 'https://www.wikidata.org/wiki/Q6045608', 'display_name': 'Intercalated disc', 'level': 4, 'score': 0.7438082}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.6233285}, {'id': 'https://openalex.org/C105702510', 'wikidata': 'https://www.wikidata.org/wiki/Q514', 'display_name': 'Anatomy', 'level': 1, 'score': 0.40876368}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.39484203}, {'id': 'https://openalex.org/C149402561', 'wikidata': 'https://www.wikidata.org/wiki/Q24776048', 'display_name': 'Cadherin', 'level': 3, 'score': 0.3804559}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.37129605}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.33325398}, {'id': 'https://openalex.org/C30145163', 'wikidata': 'https://www.wikidata.org/wiki/Q384104', 'display_name': 'Catenin', 'level': 4, 'score': 0.28261712}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.23864824}, {'id': 'https://openalex.org/C158157758', 'wikidata': 'https://www.wikidata.org/wiki/Q232438', 'display_name': 'Gap junction', 'level': 3, 'score': 0.210085}, {'id': 'https://openalex.org/C137620995', 'wikidata': 'https://www.wikidata.org/wiki/Q155769', 'display_name': 'Wnt signaling pathway', 'level': 3, 'score': 0.181268}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.14453992}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.09215158}, {'id': 'https://openalex.org/C79879829', 'wikidata': 'https://www.wikidata.org/wiki/Q5571762', 'display_name': 'Intracellular', 'level': 2, 'score': 0.061120898}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1155/2010/207835', 'pdf_url': 'https://downloads.hindawi.com/journals/drp/2010/207835.pdf', 'source': {'id': 'https://openalex.org/S102744128', 'display_name': 'Dermatology Research and Practice', 'issn_l': '1687-6105', 'issn': ['1687-6105', '1687-6113'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319869', 'host_organization_name': 'Hindawi Publishing Corporation', 'host_organization_lineage': ['https://openalex.org/P4310319869'], 'host_organization_lineage_names': ['Hindawi Publishing Corporation'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/aad5970e0b5f447f924fc5699306a629', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2879923', 'pdf_url': 'https://europepmc.org/articles/pmc2879923?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2879923', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/20585598', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1155/2010/207835', 'pdf_url': 'https://downloads.hindawi.com/journals/drp/2010/207835.pdf', 'source': {'id': 'https://openalex.org/S102744128', 'display_name': 'Dermatology Research and Practice', 'issn_l': '1687-6105', 'issn': ['1687-6105', '1687-6113'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319869', 'host_organization_name': 'Hindawi Publishing Corporation', 'host_organization_lineage': ['https://openalex.org/P4310319869'], 'host_organization_lineage_names': ['Hindawi Publishing Corporation'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.64}], 'grants': [{'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'HL081569'}, {'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': '2080068'}], 'datasets': [], 'versions': [], 'referenced_works_count': 35, 'referenced_works': ['https://openalex.org/W1489952129', 'https://openalex.org/W1566822031', 'https://openalex.org/W1965700636', 'https://openalex.org/W1977007311', 'https://openalex.org/W1978084278', 'https://openalex.org/W1982213890', 'https://openalex.org/W20132494', 'https://openalex.org/W2023634656', 'https://openalex.org/W2023958353', 'https://openalex.org/W2032094196', 'https://openalex.org/W2036211423', 'https://openalex.org/W2042329944', 'https://openalex.org/W2044726736', 'https://openalex.org/W2047832569', 'https://openalex.org/W2054286277', 'https://openalex.org/W2059759744', 'https://openalex.org/W2060452340', 'https://openalex.org/W2060868333', 'https://openalex.org/W2062921504', 'https://openalex.org/W2070416746', 'https://openalex.org/W2091013332', 'https://openalex.org/W2092349641', 'https://openalex.org/W2092922521', 'https://openalex.org/W2094647249', 'https://openalex.org/W2096649339', 'https://openalex.org/W2101389618', 'https://openalex.org/W2104329240', 'https://openalex.org/W2108188333', 'https://openalex.org/W2114474037', 'https://openalex.org/W2118567467', 'https://openalex.org/W2121038707', 'https://openalex.org/W2126286819', 'https://openalex.org/W2137898197', 'https://openalex.org/W2139781265', 'https://openalex.org/W2154148336'], 'related_works': ['https://openalex.org/W3045702683', 'https://openalex.org/W2325634192', 'https://openalex.org/W2164343437', 'https://openalex.org/W2101389618', 'https://openalex.org/W2096381532', 'https://openalex.org/W2082379549', 'https://openalex.org/W2050158045', 'https://openalex.org/W2023958353', 'https://openalex.org/W1983190060', 'https://openalex.org/W110464287'], 'abstract_inverted_index': {'Adherens': [0], 'junctions': [1, 7, 73, 92, 164], 'and': [2, 8, 14, 27, 74, 82, 131, 165], 'desmosomes': [3], 'are': [4, 19, 33, 84, 173], 'intercellular': [5], 'adhesive': [6, 47], 'essential': [9], 'for': [10], 'the': [11, 36, 39, 42, 128, 139, 155, 169], 'morphogenesis,': [12], 'differentiation,': [13], 'maintenance': [15], 'of': [16, 38, 46, 93, 102, 143, 157, 171], 'tissues': [17], 'that': [18, 147], 'subjected': [20], 'to': [21, 150], 'high': [22], 'mechanical': [23, 152], 'stress,': [24], 'including': [25], 'heart': [26, 59, 94, 156], 'skin.': [28], 'The': [29, 133, 160], 'different': [30, 163], 'junction': [31, 109, 119], 'complexes': [32], 'organized': [34], 'at': [35], 'termini': [37], 'cardiomyocyte': [40], 'called': [41], 'intercalated': [43, 141], 'disc.': [44], 'Disruption': [45], 'integrity': [48], 'via': [49], 'mutations': [50], 'in': [51, 87, 138, 154, 168, 175], 'genes': [52], 'encoding': [53], 'desmosomal': [54, 77], 'proteins': [55], 'causes': [56], 'an': [57], 'inherited': [58], 'disease,': [60], 'arrhythmogenic': [61], 'right': [62], 'ventricular': [63], 'cardiomyopathy': [64], '(ARVC).': [65], 'Besides': [66], 'plakoglobin,': [67], 'which': [68], 'is': [69, 105], 'shared': [70], 'by': [71], 'adherens': [72, 91, 118], 'desmosomes,': [75], 'other': [76, 98], 'components,': [78], 'desmoglein‐2,': [79], 'desmocollin‐2,': [80], 'plakophilin‐2,': [81], 'desmoplakin': [83], 'also': [85], 'present': [86], 'ultrastructurally': [88], 'defined': [89], 'fascia': [90], 'muscle,': [95], 'but': [96], 'not': [97], 'tissues.': [99], 'This': [100], 'mixed‐type': [101], 'junctional': [103], 'structure': [104], 'termed': [106], 'hybrid': [107], 'adhering': [108], 'or': [110], 'area': [111, 134], 'composita.': [112], 'Desmosomal': [113], 'plakophilin‐2': [114], 'directly': [115], 'interacts': [116], 'with': [117], 'protein': [120], 'alphaT‐catenin,': [121], 'providing': [122], 'a': [123], 'new': [124], 'molecular': [125], 'link': [126], 'between': [127], 'cadherin‐catenin': [129], 'complex': [130], 'desmosome.': [132], 'composita': [135], 'only': [136], 'exists': [137], 'cardiac': [140], 'disc': [142], 'mammalian': [144], 'species': [145], 'suggesting': [146], 'it': [148], 'evolved': [149], 'strengthen': [151], 'coupling': [153], 'higher': [158], 'vertebrates.': [159], 'cross‐talk': [161], 'among': [162], 'their': [166], 'implication': [167], 'pathogenesis': [170], 'ARVC': [172], 'discussed': [174], 'this': [176], 'review.': [177]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2050158045', 'counts_by_year': [{'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 5}, {'year': 2012, 'cited_by_count': 10}], 'updated_date': '2024-12-23T21:01:18.912908', 'created_date': '2016-06-24'}