Publication Information

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'https://openalex.org/W4234193889', 'https://openalex.org/W4322700972', 'https://openalex.org/W4323966388'], 'related_works': ['https://openalex.org/W345422279', 'https://openalex.org/W2800250885', 'https://openalex.org/W2572847020', 'https://openalex.org/W2383441779', 'https://openalex.org/W2292512574', 'https://openalex.org/W2258142825', 'https://openalex.org/W2062071602', 'https://openalex.org/W2027789677', 'https://openalex.org/W1991192790', 'https://openalex.org/W1829912350'], 'abstract_inverted_index': {'Alzheimer': [0, 212, 438, 446], 'disease': [1, 210, 213, 422, 439], 'is': [2, 56, 214, 268, 429, 500, 542, 621, 1277, 1420, 1606, 2394, 2398, 2523, 2549, 2659, 2667, 2681, 3100], 'characterized': [3, 99, 215, 311], 'by': [4, 216, 504, 2126, 2355, 2388, 2635, 2684], 'the': [5, 39, 45, 65, 95, 100, 120, 164, 179, 196, 217, 251, 257, 277, 307, 312, 332, 376, 391, 408, 505, 520, 558, 712, 733, 1301, 1312, 1396, 1430, 1609, 1674, 1687, 1694, 2069, 2081, 2356, 2359, 2446, 2471, 2488, 2531, 2534, 2552, 2557, 2624, 2645, 2654, 2673, 2736, 2783, 2792, 2847, 2856, 2860, 2873, 2921, 2936, 2949, 3125], 'abnormal': [6, 218], 'aggregation': [7, 107, 200, 219, 319, 412, 425, 506, 541, 1276, 1309, 1603, 1675, 2098, 2332, 2853, 2901, 2950, 2995, 3004, 3171], 'of': [8, 102, 104, 111, 220, 314, 316, 323, 433, 507, 519, 560, 604, 714, 723, 735, 1157, 1290, 1303, 1353, 1361, 1398, 1409, 1676, 1684, 1690, 1944, 1960, 2129, 2358, 2426, 2431, 2433, 2438, 2448, 2473, 2491, 2512, 2514, 2556, 2647, 2664, 2677, 2733, 2787, 2834, 2846, 2849, 2851, 2858, 2938, 2940, 2951, 3019, 3159], 'amyloid': [9, 18, 58, 88, 105, 157, 221, 230, 270, 300, 317, 369, 427, 449, 453, 508, 514, 1305, 1318, 2843, 2852, 3166], 'β': [10, 89, 106, 158, 222, 301, 318, 370, 450, 454, 509], 'peptide': [11, 223], 'into': [12, 124, 224, 336, 426, 512], 'extracellular': [13, 225], 'fibrillar': [14, 226, 513], 'deposits': [15, 227], 'known': [16, 228], 'as': [17, 38, 229, 250, 1311, 1365, 1716, 2074, 2395, 2628, 2718, 2738, 2892, 2925, 3025], 'plaques.': [19, 231], 'Soluble': [20, 232, 2119], 'oligomers': [21, 34, 59, 90, 172, 233, 246, 271, 302, 384, 1306, 1390, 1415, 1599, 1712, 2077, 2121, 2384, 2501, 2622, 2632, 2744, 2835, 2863, 2868, 2898, 2977, 2988], 'have': [22, 35, 234, 247, 607, 717, 730, 1141, 1349, 1713, 1950, 2122, 2338, 2344, 2944], 'been': [23, 36, 235, 248, 608, 718, 1143, 1714, 1951, 2123, 2346, 2945], 'observed': [24, 236, 1405, 2629], 'at': [25, 152, 237, 364, 1358, 1406], 'early': [26, 238, 1359, 2503], 'time': [27, 239, 2504, 2785], 'points': [28, 240], 'preceding': [29, 241], 'fibril': [30, 68, 114, 180, 242, 280, 326, 392, 727, 1399, 1412, 1433, 1612, 1961, 2876, 2890, 2916, 2984], 'formation,': [31, 243, 1400, 1434, 2877, 2932], 'and': [32, 113, 142, 201, 244, 325, 354, 413, 1150, 1281, 1345, 1363, 1710, 1948, 2138, 2480, 2540, 2633, 2638, 2642, 2679, 2779, 2831, 2864, 2897, 2933, 2986, 2989, 2993, 3071, 3090, 3116, 3124, 3144, 3190], 'these': [33, 185, 245, 397, 2529], 'implicated': [37, 249], 'primary': [40, 252, 1313, 2655, 2927], 'pathological': [41, 253, 431], 'species': [42, 254, 1315, 1719], 'rather': [43, 255], 'than': [44, 256, 1286], 'mature': [46, 258, 624, 1366], 'fibrils.': [47, 259, 2844], 'A': [48, 260, 602], 'significant': [49, 261, 2830], 'issue': [50, 262], 'that': [51, 76, 129, 136, 144, 171, 188, 207, 263, 288, 341, 348, 356, 383, 400, 419, 539, 547, 619, 1356, 1605, 2094, 2337, 2444, 2456, 2466, 2528, 2542, 2548, 2651, 2666, 2730, 2839, 2881, 2908, 2943, 2961, 2975, 2987, 3001], 'remains': [52, 264], 'to': [53, 67, 82, 156, 265, 279, 294, 368, 610, 1145, 1283, 1293, 1300, 1392, 1439, 1673, 1953, 2075, 2084, 2125, 2352, 2429, 2441, 2454, 2464, 2526, 2537, 2551, 2875, 2888, 2947, 3164, 3168, 3186], 'be': [54, 266, 552, 1954, 2353, 2886, 2906], 'resolved': [55, 267], 'whether': [57, 87, 269, 299, 1424, 1435, 1598, 2076, 2088], 'are': [60, 91, 173, 192, 272, 303, 385, 404, 1403, 1416, 1426, 2072, 2078, 2385, 2530, 2735, 2840, 2869, 2978], 'an': [61, 72, 175, 273, 284, 387, 553, 2096, 2399, 2980], 'obligate': [62, 92, 176, 274, 304, 388, 1427, 2870, 2981], 'intermediate': [63, 177, 275, 389, 1407, 2626, 2982], 'on': [64, 117, 276, 329, 2080, 2516, 2872], 'pathway': [66, 75, 278, 287, 1397, 1431, 1604, 1614, 2082, 2099, 2874], 'formation': [69, 181, 281, 393, 1962, 2086, 2432, 2447, 2469, 2884, 2891, 2985], 'or': [70, 78, 282, 290, 1307, 1597, 1958, 2087, 2499, 2518, 2533, 2592, 2594, 2723, 2955, 3151, 3157, 3167, 3174], 'represent': [71, 203, 283, 415, 1393, 2090, 2483, 2653, 2899, 2991], 'alternate': [73, 285], 'assembly': [74, 286, 1613], 'may': [77, 79, 202, 289, 291, 414, 551], 'not': [80, 133, 140, 174, 292, 345, 352, 386, 1421, 2524, 2585, 2915, 2979, 3015], 'lead': [81, 293], 'fiber': [83, 295, 2085, 2468, 2517, 3191], 'formation.': [84, 115, 296, 327, 1413, 2520, 2917], 'To': [85, 297], 'determine': [86, 298], 'intermediates': [93, 305, 1310, 1394, 1428, 1957, 2079, 2871], 'in': [94, 109, 163, 178, 306, 321, 375, 390, 502, 516, 732, 1316, 1395, 1429, 2470, 2672, 2791], 'fibrillization': [96, 138, 308, 350, 1158], 'pathway,': [97, 309], 'we': [98, 310, 2919, 2934], 'mechanism': [101, 313, 2848, 2937], 'action': [103, 315, 2850, 2939], 'inhibitors': [108, 191, 320, 403, 2854, 2880, 2910, 2963, 3005, 3018], 'terms': [110, 322], 'oligomer': [112, 324, 2459, 2519, 2789, 2883, 2931, 3189], 'Based': [116, 328], 'their': [118, 330, 2956, 3184], 'effects,': [119, 331], 'small': [121, 189, 333, 401, 605, 2941, 3155, 3160], 'molecules': [122, 334, 606, 738, 2942, 3156, 3161], 'segregated': [123, 335], 'three': [125, 337], 'distinct': [126, 338, 1607, 2841, 2900, 2994], 'classes:': [127, 339], 'compounds': [128, 135, 143, 148, 340, 347, 355, 360, 1140, 2515, 3143], 'inhibit': [130, 137, 145, 342, 349, 357, 611, 1146, 2948, 2970, 3187], 'oligomerization': [131, 151, 343, 363, 2427, 2439, 2481, 2913], 'but': [132, 139, 344, 351, 2914], 'fibrillization,': [134, 346], 'oligomerization,': [141, 353], 'both.': [146, 358], 'Several': [147, 359], 'selectively': [149, 361], 'inhibited': [150, 362], 'substoichiometric': [153, 365], 'concentrations': [154, 366], 'relative': [155, 367], 'monomer,': [159, 371, 2588], 'with': [160, 372, 623, 1155, 2475, 2670, 2837], 'some': [161, 373, 2909, 2962], 'active': [162, 374], 'low': [165, 377, 2719], 'nanomolar': [166, 378], 'range.': [167, 379], 'These': [168, 380, 726, 1388, 2342, 2381, 2507, 2972], 'results': [169, 381, 2959, 2998], 'indicate': [170, 382, 2527, 2729, 2974, 3000], 'pathway.': [182, 394], 'In': [183, 395], 'addition,': [184, 396], 'data': [186, 398, 2071, 2973], 'suggest': [187, 399], 'molecule': [190, 402, 2443, 3142], 'useful': [193, 405], 'for': [194, 406, 544, 557, 1432, 2487, 2630, 2741, 2930, 2983, 3003, 3176, 3183], 'clarifying': [195, 407, 2859], 'mechanisms': [197, 409], 'underlying': [198, 410], 'protein': [199, 411, 455, 510, 2558, 3170], 'potential': [204, 416], 'therapeutic': [205, 417, 555], 'agents': [206, 418], 'target': [208, 420, 2965], 'fundamental': [209, 421], 'mechanisms.': [211, 423], 'Protein': [424], 'fibrils': [428, 1367, 1441, 2596, 2896, 2990], 'a': [430, 1278, 1287, 1601, 2127, 2339, 2389, 2442, 2484, 2544, 2660, 2829, 2926], 'hallmark': [432], 'many': [434, 1677, 1682], 'neurodegenerative': [435], 'diseases,': [436], 'including': [437, 2131], '(AD).': [440], '2The': [441], 'abbreviations': [442], 'used': [443, 2486], 'are:': [444], 'AD,': [445, 2678], 'disease;': [447], 'Aβ,': [448], 'protein;': [451], 'Aβ42,': [452], 'containing': [456, 472], '42': [457], 'amino': [458], 'acids;': [459], 'BSB,': [460], '(trans,': [461, 3289], 'trans)-1-bromo-2,5-bis-(3-hydroxycarbonyl-4-hydroxy)styrylbenzene;': [462], 'C17,': [463], 'trimethyl(tetradecyl)ammonium': [464], 'bromide;': [465, 468], 'C16,': [466], 'hexadecyltrimethylammonium': [467, 3710], 'TBS-T,': [469], 'Tris-buffered': [470], 'saline': [471], '0.01%': [473], 'Tween': [474], '20;': [475], 'TEM,': [476], 'transmission': [477], 'electron': [478, 2636], 'microscopy;': [479], 'ThT,': [480], 'thioflavin': [481, 3010], 'T;': [482], 'PBS,': [483], 'phosphate-buffered': [484], 'saline;': [485], 'ELISA,': [486], 'enzyme-linked': [487], 'immunosorbent': [488], 'assay;': [489], 'AR,': [490], 'anti-rabbit': [491, 3106], 'IgG;': [492], 'HFIP,': [493], 'hexafluoroisopropanol;': [494], 'ADDL,': [495], 'Aβ-derived': [496], 'diffusable': [497], 'ligand.': [498], 'AD': [499, 561, 2838], 'characterized,': [501], 'part,': [503], '(Aβ)': [511], 'plaques': [515], 'select': [517], 'areas': [518], 'brain': [521], '(1Selkoe': [522], 'D.J.': [523, 565, 994, 1323, 1561, 3418, 4039], 'Neuron.': [524], '1991;': [525, 663], '6:': [526, 3856, 3907], '487-498Abstract': [527], 'Full': [528, 780, 782, 943, 973, 975, 1001, 1003, 1382, 1455, 1473, 1495, 1497, 1570, 1572, 1810, 1812, 1861, 1863, 2004, 2006, 2030, 2032, 2058, 2060, 2153, 2175, 2177, 2197, 2324, 2375, 2815, 2817, 3052, 3214, 3216, 3246, 3248, 3279, 3281, 3373, 3375, 3564, 3566, 3646, 3648, 3700, 3702, 3748, 3750, 3797, 3799, 3884, 3886, 3937, 3939, 3968, 3970, 4046, 4048, 4130, 4132, 4161, 4163, 4219, 4221, 4249, 4251], 'Text': [529, 781, 783, 944, 974, 976, 1002, 1004, 1383, 1456, 1474, 1496, 1498, 1571, 1573, 1811, 1813, 1862, 1864, 2005, 2007, 2031, 2033, 2059, 2061, 2154, 2176, 2178, 2198, 2325, 2376, 2816, 2818, 3053, 3215, 3217, 3247, 3249, 3280, 3282, 3374, 3376, 3565, 3567, 3647, 3649, 3701, 3703, 3749, 3751, 3798, 3800, 3885, 3887, 3938, 3940, 3969, 3971, 4047, 4049, 4131, 4133, 4162, 4164, 4220, 4222, 4250, 4252], 'PDF': [530, 784, 945, 977, 1005, 1384, 1457, 1475, 1499, 1574, 1814, 1865, 2008, 2034, 2062, 2155, 2179, 2199, 2326, 2377, 2819, 3054, 3218, 3250, 3283, 3377, 3568, 3650, 3704, 3752, 3801, 3888, 3941, 3972, 4050, 4134, 4165, 4223, 4253], 'PubMed': [531, 570, 582, 597, 648, 666, 686, 707, 747, 785, 804, 819, 849, 876, 896, 922, 946, 978, 1006, 1034, 1053, 1086, 1105, 1134, 1184, 1204, 1230, 1249, 1269, 1328, 1340, 1385, 1458, 1476, 1500, 1523, 1541, 1575, 1592, 1646, 1664, 1730, 1753, 1772, 1789, 1815, 1838, 1866, 1881, 1894, 1911, 1938, 1985, 2009, 2035, 2063, 2114, 2156, 2180, 2200, 2221, 2266, 2295, 2327, 2378, 2420, 2578, 2615, 2708, 2773, 2820, 3055, 3219, 3251, 3284, 3314, 3338, 3378, 3398, 3423, 3454, 3471, 3488, 3511, 3531, 3569, 3591, 3619, 3651, 3674, 3705, 3721, 3753, 3771, 3802, 3820, 3839, 3858, 3889, 3909, 3942, 3973, 4000, 4021, 4051, 4073, 4104, 4135, 4166, 4194, 4224, 4254, 4273, 4294, 4322], 'Scopus': [532, 571, 598, 649, 667, 708, 748, 786, 805, 820, 850, 877, 897, 923, 947, 979, 1007, 1035, 1054, 1087, 1106, 1135, 1185, 1205, 1231, 1250, 1270, 1329, 1501, 1524, 1542, 1576, 1593, 1647, 1665, 1731, 1754, 1773, 1790, 1816, 1839, 1867, 1882, 1895, 1912, 1939, 1986, 2010, 2036, 2064, 2115, 2181, 2222, 2267, 2296, 2421, 2579, 2616, 2709, 2774, 2821, 3220, 3252, 3285, 3315, 3339, 3379, 3399, 3424, 3455, 3472, 3489, 3512, 3532, 3570, 3592, 3620, 3652, 3675, 3706, 3722, 3754, 3772, 3803, 3821, 3840, 3859, 3890, 3910, 3943, 3974, 4001, 4022, 4052, 4074, 4105, 4136, 4167, 4195, 4225, 4255, 4274, 4295, 4323], '(2042)': [533], 'Google': [534, 573, 583, 600, 651, 669, 687, 710, 750, 788, 807, 822, 852, 879, 899, 925, 949, 981, 1009, 1037, 1056, 1089, 1108, 1137, 1187, 1207, 1233, 1252, 1272, 1331, 1341, 1386, 1459, 1477, 1503, 1526, 1544, 1578, 1595, 1624, 1649, 1667, 1733, 1756, 1775, 1792, 1818, 1841, 1869, 1884, 1897, 1914, 1941, 1988, 2012, 2038, 2066, 2117, 2157, 2183, 2201, 2224, 2269, 2298, 2328, 2379, 2423, 2581, 2618, 2711, 2776, 2823, 3056, 3222, 3254, 3287, 3317, 3341, 3381, 3401, 3426, 3457, 3474, 3491, 3514, 3534, 3572, 3594, 3622, 3654, 3677, 3708, 3724, 3756, 3774, 3805, 3823, 3842, 3861, 3892, 3912, 3945, 3976, 4003, 4024, 4054, 4076, 4107, 4138, 4169, 4197, 4227, 4257, 4276, 4297, 4325], 'Scholar).': [535, 601, 1138, 1273, 1342, 1387, 1668, 1942, 2067, 2118, 2329, 2380, 2424, 2582, 2619, 2712, 2777, 2824, 3057], 'Compelling': [536], 'evidence': [537, 1297], 'indicates': [538], 'Aβ': [540, 612, 724, 1275, 2120, 2587, 2589, 2595, 2648, 2665], 'critical': [543], 'neurodegeneration,': [545], 'suggesting': [546], 'preventing': [548], 'this': [549, 1151], 'process': [550, 1280], 'effective': [554], 'approach': [556], 'treatment': [559], '(2Hardy': [562, 1320], 'J.': [563, 681, 701, 742, 759, 774, 798, 830, 845, 859, 870, 892, 937, 966, 967, 995, 1030, 1120, 1130, 1165, 1180, 1200, 1321, 1489, 1517, 1536, 1564, 1586, 1747, 1766, 1804, 1821, 1832, 1855, 1905, 1998, 2019, 2024, 2045, 2052, 2108, 2169, 2188, 2191, 2282, 2307, 2313, 2318, 2809, 3035, 3041, 3046, 3208, 3240, 3273, 3352, 3367, 3466, 3494, 3505, 3525, 3558, 3587, 3615, 3640, 3694, 3716, 3742, 3791, 3846, 3878, 3897, 3930, 3931, 3962, 4015, 4040, 4090, 4100, 4124, 4155, 4213, 4243, 4290, 4318, 4344], 'Selkoe': [564, 1322, 1560, 3417], 'Science.': [566, 1324, 2416, 2574, 2611], '2002;': [567, 998, 1325, 1807, 1858, 1891, 2055, 2292, 3508, 4043], '297:': [568, 1326], '353-356Crossref': [569, 1327], '(9917)': [572, 1330], 'Scholar,': [574, 584, 652, 670, 688, 751, 789, 808, 823, 853, 880, 900, 926, 950, 982, 1010, 1038, 1057, 1090, 1109, 1188, 1208, 1234, 1253, 1332, 1460, 1478, 1504, 1527, 1545, 1579, 1625, 1650, 1734, 1757, 1776, 1793, 1819, 1842, 1870, 1885, 1898, 1915, 1989, 2013, 2039, 2158, 2184, 2202, 2225, 2270, 2299, 3382, 3402, 3427, 3458, 3492, 3535, 3595, 3757, 3806, 4198, 4228, 4298], '3Glabe': [575, 1333], 'C.C.': [576, 1334], 'Subcell.': [577, 1335], 'Biochem.': [578, 891, 915, 1029, 1199, 1223, 1336, 3586, 3614, 3993, 4187, 4289, 4317], '2005;': [579, 594, 744, 816, 1083, 1337, 1750, 1835, 2001, 3211, 3243, 3276, 3468, 3561, 3643, 3697, 3718, 3745, 3794, 3855, 3881, 3906, 3965, 4127, 4158, 4216, 4347], '38:': [580, 1338, 1662], '167-177Crossref': [581, 1339], '4Bloom': [585], 'G.S.': [586], 'Ren': [587], 'K.': [588, 791, 793, 910, 1092, 1094, 1218, 1618, 1761, 3518, 3520, 3988, 4008, 4010, 4182, 4234], 'Glabe': [589, 657, 677, 2189, 2316, 2414, 2572, 2609, 2696, 2803, 3044, 3552], 'C.G.': [590, 658, 678, 2415, 2573, 2610, 2697, 2804, 3553], 'Biochim.': [591, 1099], 'Biophys.': [592, 916, 1100, 1224, 3994, 4188], 'Acta.': [593, 1101], '1739:': [595], '116-124Crossref': [596], '(29)': [599], 'number': [603], 'reported': [609, 1952, 2740, 2946, 3162], 'fibrillogenesis.': [613], 'Since': [614], 'it': [615, 1419, 2904], 'was': [616, 1153, 3023, 3092, 3109, 3129], 'initially': [617], 'presumed': [618], 'toxicity': [620, 2646, 3173], 'associated': [622, 2669, 2836], 'fibers': [625, 2335, 2498, 2539], '(5Howlett': [626], 'D.R.': [627, 882, 1012, 1190, 3482, 3577, 3597, 4280, 4300], 'Jennings': [628, 1019, 3604, 4307], 'K.H.': [629, 1020, 2703, 3605, 4308], 'Lee': [630, 3302], 'D.C.': [631], 'Clark': [632, 1722], 'M.S.': [633, 1263, 3332, 3392, 3668, 4067], 'Brown': [634], 'F.': [635, 696, 765, 863, 1016, 2276, 2278, 3358, 3537, 3601, 4304], 'Wetzel': [636, 935, 1074], 'R.': [637, 740, 769, 839, 936, 1075, 1122, 1174, 1850, 1904, 1925, 1972, 2235, 2403, 2561, 2598, 2695, 2752, 3362, 3437, 3551, 3714, 4092], 'Wood': [638, 1025, 3610, 4313], 'S.J.': [639, 928, 1026, 1255, 1514, 3324, 3384, 3611, 3660, 4059, 4314], 'Camilleri': [640, 3764, 3813], 'P.': [641, 753, 861, 954, 2247, 2756, 2764, 3346, 3408, 3478, 3761, 3765, 3810, 3814, 3918], 'Roberts': [642, 1511], 'G.W.': [643], 'Neurodegeneration.': [644], '1995;': [645, 1266, 3335, 3395, 3671, 4070], '4:': [646, 1380, 1453, 1471, 2151, 2373], '23-32Crossref': [647], '(179)': [650], '6Pike': [653], 'C.J.': [654, 672, 1512], 'Walencewicz': [655, 675], 'A.J.': [656, 676, 1759], 'Cotman': [659, 679, 2314, 2412, 2570, 2607, 3042], 'C.W.': [660, 680, 2413, 2571, 2608], 'Brain': [661], 'Res.': [662, 800, 917, 1225, 3527, 3995, 4017, 4189], '563:': [664], '311-314Crossref': [665], '(806)': [668], '7Pike': [671], 'Burdick': [673], 'D.': [674, 698, 988, 1995, 2301, 3029, 3759, 3808, 4033], 'Neurosci.': [682, 799, 1264, 3333, 3393, 3507, 3526, 3669, 3854, 3905, 4016, 4068], '1993;': [683], '13:': [684], '1676-1687Crossref': [685], '8Seilheimer': [689], 'B.': [690, 692, 755, 855, 932, 964, 2186, 2243, 2303, 3031, 3295, 3348, 3928], 'Bohrmann': [691, 754, 3347], 'Bondolfi': [693], 'L.': [694, 930, 1124, 2280, 2693, 2800, 3496, 3498, 4094], 'Muller': [695, 862], 'Stuber': [697], 'Dobeli': [699, 868], 'H.': [700, 795, 869, 912, 958, 1024, 1096, 1220, 1616, 2043, 2762, 3441, 3464, 3522, 3609, 3922, 3990, 4012, 4184, 4240, 4312], 'Struct.': [702, 871], 'Biol.': [703, 775, 872, 938, 968, 996, 1378, 1451, 1469, 1490, 1519, 1565, 1588, 1749, 1768, 1805, 1834, 1856, 1907, 1999, 2025, 2053, 2110, 2149, 2170, 2192, 2319, 2371, 2810, 3047, 3209, 3241, 3274, 3368, 3559, 3641, 3695, 3743, 3792, 3879, 3932, 3963, 4041, 4125, 4156, 4214, 4244, 4345], '1997;': [704, 1379, 1452, 1470, 1492, 2150, 2172, 2218, 2372, 3768, 3817], '119:': [705], '59-71Crossref': [706], '(199)': [709], 'Scholar),': [711, 1596, 3223, 3255, 3288, 3318, 3342, 3475, 3515, 3573, 3623, 3655, 3678, 3709, 3725, 3775, 3824, 3843, 3862, 3893, 3913, 3946, 3977, 4004, 4025, 4055, 4077, 4108, 4139, 4170, 4258, 4277, 4326], 'majority': [713], 'inhibitor': [715, 728, 737, 2437], 'screens': [716, 729], 'directed': [719], 'toward': [720], 'identifying': [721], 'modulators': [722], 'fibrillization.': [725, 2971], 'resulted': [731], 'discovery': [734], 'multiple': [736], '(9Sabate': [739, 3713], 'Estelrich': [741, 3715], 'Langmuir.': [743, 3717], '21:': [745, 3719], '6944-6949Crossref': [746, 3720], '(63)': [749, 3723], '10Kuner': [752], 'Tjernberg': [756, 3349], 'L.O.': [757, 3350], 'Naslund': [758, 3351], 'Huber': [760, 864, 3353], 'G.': [761, 1763, 1765, 1797, 1827, 2286, 2766, 3354], 'Celenk': [762, 3355], 'S.': [763, 904, 992, 1048, 1081, 1212, 1244, 1641, 1825, 1852, 1900, 2047, 2216, 2261, 2689, 2796, 3195, 3201, 3227, 3233, 3260, 3266, 3309, 3356, 3449, 3627, 3633, 3681, 3687, 3729, 3735, 3763, 3778, 3784, 3812, 3848, 3865, 3871, 3899, 3949, 3955, 3982, 4037, 4111, 4117, 4142, 4148, 4176, 4200, 4206, 4238, 4266, 4331, 4337], 'Gruninger-Leitch': [764, 3357], 'Richards': [766, 3359], 'J.G.': [767, 2768, 3360], 'Jakob-Roetne': [768, 3361], 'Kemp': [770, 3363], 'J.A.': [771, 3364], 'Nordstedt': [772, 866, 3365], 'C.': [773, 867, 956, 1022, 2017, 2190, 2233, 2249, 2315, 2317, 3043, 3045, 3366, 3607, 3920, 4310], 'Chem.': [776, 815, 939, 969, 997, 1377, 1450, 1468, 1491, 1566, 1806, 1857, 2000, 2026, 2054, 2148, 2171, 2193, 2320, 2370, 2811, 3048, 3210, 3242, 3275, 3369, 3560, 3642, 3696, 3744, 3793, 3880, 3933, 3964, 4042, 4126, 4157, 4215, 4245, 4346], '2000;': [777, 873, 1520, 3311, 3370, 3451], '275:': [778, 3371], '1673-1678Abstract': [779, 3372], '(74)': [787, 1883, 3380], '11Ono': [790], 'Hasegawa': [792, 1093, 3206, 3238, 3271, 3519, 3638, 3692, 3740, 3789, 3876, 3960, 4009, 4122, 4153, 4211, 4342], 'Naiki': [794, 1095, 3521, 4011], 'Yamada': [796, 1097, 3523, 4013], 'M.': [797, 857, 952, 962, 1061, 1063, 1067, 1098, 1529, 1921, 1968, 2049, 2237, 2272, 2290, 2305, 2309, 2701, 2760, 3033, 3037, 3199, 3205, 3207, 3231, 3237, 3239, 3264, 3270, 3272, 3524, 3631, 3637, 3639, 3685, 3691, 3693, 3733, 3739, 3741, 3782, 3788, 3790, 3869, 3875, 3877, 3916, 3926, 3953, 3959, 3961, 4014, 4115, 4121, 4123, 4146, 4152, 4154, 4204, 4210, 4212, 4335, 4341, 4343], '2004;': [801, 1102, 1131, 1727, 1786, 1935, 1982, 2027, 3528, 4018, 4101, 4270], '75:': [802, 3529, 4019], '742-750Crossref': [803, 3530, 4020], '(780)': [806, 3533, 4023], '12Cheng': [809], 'X.': [810], 'van': [811], 'Breemen': [812], 'R.B.': [813], 'Anal': [814], '77:': [817], '7012-7015Crossref': [818], '(53)': [821, 878], '13De': [824], 'Felice': [825, 1111, 1160, 4081], 'F.G.': [826, 1112, 1161, 4082], 'Houzel': [827, 1162], 'J.C.': [828, 1163], 'Garcia-Abreu': [829, 1119, 1164, 4089], 'Louzada': [831, 1166], 'Jr.,': [832, 1167, 1466, 1658], 'P.R.': [833, 1168], 'Afonso': [834, 1169], 'R.C.': [835, 1170], 'Meirelles': [836, 1171], 'M.N.': [837, 1114, 1172, 4084], 'Lent': [838, 1173], 'Neto': [840, 1175], 'V.M.': [841, 1176, 3303], 'Ferreira': [842, 1127, 1177, 4097], 'S.T.': [843, 1128, 1178, 4098], 'FASEB': [844, 1129, 1179, 4099], '2001;': [846, 1181, 1589], '15:': [847, 1182], '1297-1299Crossref': [848, 1183], '(103)': [851, 1186], '14Bohrmann': [854], 'Adrian': [856], 'Dubochet': [858], 'Kuner': [860], 'W.': [865], '130:': [874], '232-246Crossref': [875], '15Howlett': [881, 1189], 'George': [883, 1191, 3578, 4281], 'A.R.': [884, 1192, 1778, 3579, 4282], 'Owen': [885, 1193, 3580, 4283], 'D.E.': [886, 1194, 3581, 4284], 'Ward': [887, 1195, 3582, 4285], 'R.V.': [888, 1196, 3583, 4286], 'Markwell': [889, 1027, 1197, 3584, 3612, 4287, 4315], 'R.E.': [890, 1028, 1198, 3585, 3613, 3831, 4288, 4316], '1999;': [893, 1031, 1201, 1538, 1567, 1661, 3588, 3616, 4291, 4319], '343:': [894, 1202, 3589, 4292], '419-423Crossref': [895, 1203, 3590, 4293], '(129)': [898, 1206, 3593, 4296], '16Tomiyama': [901, 1209], 'T.': [902, 908, 1210, 1216, 3203, 3235, 3268, 3635, 3689, 3737, 3786, 3873, 3957, 3980, 3986, 4119, 4150, 4174, 4180, 4208, 4230, 4339], 'Asano': [903, 1211, 3981, 4175, 4237], 'Suwa': [905, 1213, 3983, 4177, 4235], 'Y.': [906, 1214, 1551, 1553, 3984, 4178, 4236, 4262, 4264], 'Morita': [907, 1215, 3985, 4179], 'Kataoka': [909, 1217, 3987, 4181, 4233], 'Mori': [911, 1219, 3989, 4183], 'Endo': [913, 1221, 3991, 4185, 4241], 'N.': [914, 1222, 1823, 2284, 3197, 3229, 3262, 3439, 3629, 3683, 3731, 3780, 3867, 3951, 3992, 4113, 4144, 4186, 4202, 4242, 4333], 'Commun.': [918, 1226, 3996, 4190], '1994;': [919, 1050, 1227, 1246, 2194, 3485, 3997, 4191], '204:': [920, 1228, 3998, 4192], '76-83Crossref': [921, 1229, 3999, 4193], '(148)': [924, 1232, 1774, 4002, 4196], '17Wood': [927], 'MacKenzie': [929], 'Maleeff': [931], 'Hurle': [933], 'M.R.': [934, 3545], '1996;': [940, 1621, 1643, 4246], '271:': [941, 4247], '4086-4092Abstract': [942], '(155)': [948], '18Pappolla': [951], 'Bozner': [953, 3917], 'Soto': [955, 3919], 'Shao': [957, 3921], 'Robakis': [959, 3923], 'N.K.': [960, 3924], 'Zagorski': [961, 3925], 'Frangione': [963, 3927], 'Ghiso': [965, 3929], '1998;': [970, 2263, 3420, 3836, 3934], '273:': [971, 3935], '7185-7188Abstract': [972, 3936], '(295)': [980, 3944], '19Lashuel': [983], 'H.A.': [984, 4029], 'Hartley': [985, 1548, 4030], 'D.M.': [986, 1480, 1547, 1549, 2160, 3293, 3406, 4031], 'Balakhaneh': [987, 4032], 'Aggarwal': [989, 4034], 'A.': [990, 1040, 1049, 1082, 1236, 1245, 1482, 1557, 1627, 1642, 1923, 1970, 1991, 2107, 2162, 2204, 2217, 2262, 2311, 2699, 2798, 3039, 3310, 3433, 3450, 4035, 4232], 'Teichberg': [991, 4036], 'Callaway': [993, 4038], '277:': [999, 1808, 1859, 2056, 4044], '42881-42890Abstract': [1000, 4045], '(138)': [1008, 4053], '20Howlett': [1011, 3596, 4299], 'Perry': [1013, 3598, 4301], 'A.E.': [1014, 3599, 4302], 'Godfrey': [1015, 3600, 4303], 'Swatton': [1017, 3602, 4305], 'J.E.': [1018, 3414, 3603, 4306], 'Spitzfaden': [1021, 3606, 4309], 'Wadsworth': [1023, 3608, 4311], '340:': [1032, 3617, 4320], '283-289Crossref': [1033, 3618, 4321], '(186)': [1036, 3621, 4324], '21Lorenzo': [1039, 1235], 'Yankner': [1041, 1237], 'B.A.': [1042, 1238, 2231, 3833], 'Proc.': [1043, 1076, 1239, 1636, 2211, 2256, 3304, 3444], 'Natl.': [1044, 1077, 1240, 1637, 2212, 2257, 3305, 3445], 'Acad.': [1045, 1078, 1241, 1638, 2213, 2258, 3306, 3446], 'Sci.': [1046, 1079, 1242, 1639, 2214, 2259, 3307, 3447], 'U.': [1047, 1080, 1243, 1640, 2023, 2215, 2260, 3308, 3448], '91:': [1051, 1247], '12243-12247Crossref': [1052, 1248], '(1259)': [1055, 1251], '22Williams': [1058], 'A.D.': [1059, 1889], 'Sega': [1060], 'Chen': [1062, 3548], 'Kheterpal': [1064], 'I.': [1065, 2241], 'Geva': [1066], 'Berthelier': [1068], 'V.': [1069, 1902, 1919, 1966, 3429], 'Kaleta': [1070], 'D.T.': [1071], 'Cook': [1072], 'K.D.': [1073], '102:': [1084], '7115-7120Crossref': [1085], '(116)': [1088], '23Ono': [1091], '1690:': [1103], '193-202Crossref': [1104], '(206)': [1107], '24De': [1110], 'Vieira': [1113, 4083], 'Saraiva': [1115, 4085], 'L.M.': [1116, 4086], 'Figueroa-Villar': [1117, 4087], 'J.D.': [1118, 1370, 1443, 1462, 1652, 2015, 2141, 2363, 4088], 'Liu': [1121, 4091], 'Chang': [1123, 3497, 4093], 'Klein': [1125, 2254, 2805, 3501, 4095], 'W.L.': [1126, 2255, 2806, 3502, 4096], '18:': [1132, 4102], '1366-1372Crossref': [1133, 4103], '(168)': [1136, 4106], 'Some': [1139], 'also': [1142, 2345], 'shown': [1144], 'Aβ-mediated': [1147], 'cellular': [1148], 'toxicity,': [1149], 'activity': [1152], 'correlated': [1154], 'modulation': [1156], '(13De': [1159], '25Pollack': [1254, 3383], 'Sadler': [1256, 3325, 3385, 3661, 4060], 'II,': [1257, 3326, 3386, 3662, 4061], 'Hawtin': [1258, 3327, 3387, 3663, 4062], 'S.R.': [1259, 3328, 3388, 3664, 4063], 'Tailor': [1260, 3329, 3389, 3665, 4064], 'V.J.': [1261, 3330, 3390, 3666, 4065], 'Shearman': [1262, 3331, 3391, 3667, 4066], 'Lett.': [1265, 3334, 3394, 3484, 3670, 3767, 3816, 4069], '197:': [1267, 3336, 3396, 3672, 4071], '211-214Crossref': [1268, 3337, 3397, 3673, 4072], '(83)': [1271, 3340, 3400, 3676, 4075], 'However,': [1274], 'complicated': [1279], 'appears': [1282], 'involve': [1284], 'more': [1285, 2726], 'simple': [1288], 'conversion': [1289], 'soluble': [1291, 1304, 1695, 2383, 2631, 2661, 2788, 2976], 'monomer': [1292], 'fiber.': [1294], 'More': [1295], 'recent': [1296, 2727], 'has': [1298], 'pointed': [1299], 'role': [1302], 'prefibrillar': [1308, 2136, 2382], 'toxic': [1314, 2656], 'degenerative': [1317], 'diseases': [1319], 'Electron': [1343, 3065], 'microscopy': [1344, 1348, 2637, 2641], 'atomic': [1346, 2639], 'force': [1347, 2640], 'identified': [1350], 'spherical': [1351, 1389, 2360], 'particles': [1352], '∼3–10': [1354], 'nm': [1355], 'appear': [1357, 1368, 1391, 2351], 'times': [1360, 1408], 'incubation': [1362, 1410], 'disappear': [1364], '(26Harper': [1369, 1442, 2140, 2362], 'Wong': [1371, 1444, 1653, 2142, 2364], 'S.S.': [1372, 1445, 1654, 2143, 2365, 3547], 'Lieber': [1373, 1446, 1463, 1655, 2144, 2366], 'C.M.': [1374, 1447, 1464, 1656, 2103, 2145, 2288, 2367], 'Lansbury': [1375, 1448, 1465, 1657, 2146, 2368], 'P.T.': [1376, 1449, 1467, 1659, 2147, 2369], '119-125Abstract': [1381, 1454, 2152, 2374], 'because': [1401, 2349, 2866], 'they': [1402, 1425, 1436, 2089, 2350, 2652], 'transiently': [1404], 'during': [1411], 'Although': [1414, 2713], 'kinetic': [1417], 'intermediates,': [1418], 'yet': [1422], 'clear': [1423], 'coalesce': [1437], 'directly': [1438], 'form': [1440, 2336, 2663, 3137], '28Harper': [1461], '951-959Abstract': [1472], '29Walsh': [1479, 2159], 'Lomakin': [1481, 1556, 2161], 'Benedek': [1483, 1558, 1630, 2163, 2209], 'G.B.': [1484, 1559, 1631, 2164, 2210], 'Condron': [1485, 1554, 1582, 2165], 'M.M.': [1486, 1555, 1583, 2166], 'Teplow': [1487, 1562, 1584, 1634, 2167, 2205, 3415], 'D.B.': [1488, 1563, 1585, 1635, 2168, 2206, 3416], '272:': [1493, 2173], '22364-22372Abstract': [1494, 2174], '(907)': [1502, 2182], '30Blackley': [1505], 'H.K.': [1506], 'Sanders': [1507], 'G.H.': [1508], 'Davies': [1509], 'M.C.': [1510], 'Tendler': [1513], 'Wilkinson': [1515], 'M.J.': [1516, 3500], 'Mol.': [1518, 1587, 1748, 1767, 1833, 1906, 2109, 3506], '298:': [1521], '833-840Crossref': [1522], '(154)': [1525], '31Nybo': [1528], 'Svehag': [1530], 'S.E.': [1531, 1746], 'Holm': [1532], 'Nielsen': [1533], 'E.': [1534, 2274, 2405, 2563, 2600, 3431, 3435, 4268], 'Scand.': [1535], 'Immunol.': [1537], '49:': [1539], '219-223Crossref': [1540], '(52)': [1543], '32Walsh': [1546], 'Kusumoto': [1550], 'Fezoui': [1552], '274:': [1568], '25945-25952Abstract': [1569], '(946)': [1577], '33Kirkitadze': [1580], 'M.D.': [1581], '312:': [1590], '1103-1119Crossref': [1591], '(572)': [1594], 'populate': [1600, 2095], 'different': [1602, 2952], 'from': [1608, 2842, 3064, 3076, 3084, 3093, 3102, 3111, 3120, 3130, 3149], 'classic': [1610], 'nucleation-dependent': [1611], '(34Naiki': [1615], 'Nakakuki': [1617], 'Lab.': [1619], 'Invest.': [1620], '74:': [1622], '374-383PubMed': [1623], '35Lomakin': [1626], 'Chung': [1628], 'D.S.': [1629], 'Kirschner': [1632, 2207], 'D.A.': [1633, 1742, 1931, 1978, 2208], '93:': [1644], '1125-1129Crossref': [1645], '(708)': [1648], '36Harper': [1651], 'Biochemistry.': [1660, 1785, 1877, 1890, 1934, 1981, 2769, 3419, 3467, 4269], '8972-8980Crossref': [1663], '(441)': [1666], 'This': [1669, 2521], 'same': [1670, 1688, 2625, 2737, 2784], 'controversy': [1671], 'extends': [1672], 'other': [1678, 2742, 3146], 'amyloidogenic': [1679, 2953], 'proteins,': [1680], 'since': [1681], 'types': [1683], 'amyloids': [1685], 'display': [1686, 2623], 'type': [1689], 'kinetically': [1691], 'unstable': [1692], 'intermediate,': [1693], 'oligomer.': [1696], 'Insulin,': [1697], 'immunoglobulin': [1698], 'light': [1699], 'chain,': [1700], 'amylin,': [1701, 1946], 'α-synuclein,': [1702], 'transthyretin,': [1703], 'prion': [1704], 'protein,': [1705], 'β2-microglobulin,': [1706], 'β-lactoglobulin,': [1707], 'phosphoglycerate': [1708], 'kinase,': [1709], 'albebetin': [1711, 1949], 'described': [1715, 2717, 3027], '"off': [1717, 2091], 'pathway"': [1718, 1956, 2092], '(37Gosal': [1720], 'W.S.': [1721, 1736], 'A.H.': [1723], 'Ross-Murphy': [1724], 'S.B.': [1725, 1801, 1887], 'Biomacromolecules.': [1726], '5:': [1728], '2408-2419Crossref': [1729], '(153)': [1732], '38Gosal': [1735], 'Morten': [1737], 'I.J.': [1738], 'Hewitt': [1739], 'E.W.': [1740], 'Smith': [1741], 'Thomson': [1743], 'N.H.': [1744], 'Radford': [1745], '351:': [1751], '850-864Crossref': [1752], '(285)': [1755], '39Modler': [1758], 'Gast': [1760], 'Lutsch': [1762], 'Damaschun': [1764], '2003;': [1769, 1878, 2111, 2417, 2575, 2612], '325:': [1770, 2112], '135-148Crossref': [1771], '40Hurshman': [1777], 'White': [1779], 'J.T.': [1780], 'Powers': [1781], 'E.T.': [1782], 'Kelly': [1783], 'J.W.': [1784], '43:': [1787, 1936, 1983, 4271], '7365-7381Crossref': [1788], '(263)': [1791], '41Baskakov': [1794], 'I.V.': [1795], 'Legname': [1796], 'Baldwin': [1798], 'M.A.': [1799, 1927, 1974, 2041], 'Prusiner': [1800], 'Cohen': [1802], 'F.E.': [1803], '21140-21148Abstract': [1809], '(379)': [1817], '42Kaylor': [1820], 'Bodner': [1822], 'Edridge': [1824], 'Yamin': [1826], 'Hong': [1828, 1994], 'D.P.': [1829], 'Fink': [1830, 1853, 1875, 1996], 'A.L.': [1831, 1854, 1876, 1997], '353:': [1836], '357-372Crossref': [1837], '(134)': [1840, 3473], '43Souillac': [1843], 'P.O.': [1844, 1872], 'Uversky': [1845, 1873, 1992], 'V.N.': [1846, 1874, 1993], 'Millett': [1847], 'I.S.': [1848], 'Khurana': [1849], 'Doniach': [1851], '12666-12679Abstract': [1860], '(104)': [1868, 3490], '44Souillac': [1871], '42:': [1879], '8094-8104Crossref': [1880], '45Padrick': [1886], 'Miranker': [1888], '41:': [1892], '4694-4703Crossref': [1893], '(264)': [1896], '46Grudzielanek': [1899], 'Smirnovas': [1901], 'Winter': [1903], '2006;': [1908, 2705, 2770, 2812], '356:': [1909], '497-509Crossref': [1910], '(91)': [1913], '47Morozova-Roche': [1916], 'L.A.': [1917, 1964], 'Zamotin': [1918, 1965], 'Malisauskas': [1920, 1967], 'Ohman': [1922, 1969], 'Chertkova': [1924, 1971], 'Lavrikova': [1926, 1973], 'Kostanyan': [1928, 1975], 'I.A.': [1929, 1976], 'Dolgikh': [1930, 1977], 'Kirpichnikov': [1932, 1979], 'M.P.': [1933, 1980, 2227, 2802, 3297], '9610-9619Crossref': [1937, 1984], '(41)': [1940, 1987], 'Oligomers': [1943], 'insulin,': [1945], 'huntingtin,': [1947], '"on': [1955], 'precursors': [1959], '(47Morozova-Roche': [1963], '48Ahmad': [1990], '280:': [2002, 3212, 3244, 3277, 3562, 3644, 3698, 3746, 3795, 3882, 3966, 4128, 4159, 4217, 4348], '42669-42675Abstract': [2003], '(197)': [2011, 3316], '49Green': [2014], 'Goldsbury': [2016], 'Kistler': [2018], 'Cooper': [2020], 'G.J.': [2021], 'Aebi': [2022], '279:': [2028], '12206-12212Abstract': [2029], '(128)': [2037], '50Poirier': [2040], 'Li': [2042], 'Macosko': [2044], 'Cai': [2046], 'Amzel': [2048], 'Ross': [2050], 'C.A.': [2051], '41032-41037Abstract': [2057], '(301)': [2065], 'Therefore,': [2068, 2825], 'published': [2070], 'equivocal': [2073], 'leading': [2083], 'aggregates': [2093], 'alternative': [2097], '(51Gorman': [2100], 'P.M.': [2101, 2758], 'Yip': [2102], 'Fraser': [2104], 'P.E.': [2105], 'Chakrabartty': [2106], '743-757Crossref': [2113], '(86)': [2116, 3841], 'referred': [2124], 'variety': [2128], 'names,': [2130], 'amorphous': [2132], 'aggregates,': [2133, 2137], 'micelles,': [2134], 'protofibrils,': [2135], 'ADDLs': [2139, 2714, 2734], '52Soreghan': [2185], 'Kosmoski': [2187, 2306, 3034], '269:': [2195], '28551-28554Abstract': [2196], '53Lomakin': [2203], '94:': [2219], '7942-7947Crossref': [2220], '(462)': [2223], '55Lambert': [2226], 'Barlow': [2228], 'A.K.': [2229], 'Chromy': [2230], 'Edwards': [2232], 'Freed': [2234], 'Liosatos': [2236], 'Morgan': [2238], 'T.E.': [2239], 'Rozovsky': [2240], 'Trommer': [2242], 'Viola': [2244], 'K.L.': [2245], 'Wals': [2246], 'Zhang': [2248, 3294], 'Finch': [2250], 'C.E.': [2251], 'Krafft': [2252], 'G.A.': [2253], '95:': [2264], '6448-6453Crossref': [2265], '(2923)': [2268], '56Bucciantini': [2271], 'Giannoni': [2273], 'Chiti': [2275], 'Baroni': [2277], 'Formigli': [2279], 'Zurdo': [2281], 'Taddei': [2283], 'Ramponi': [2285], 'Dobson': [2287], 'Stefani': [2289], 'Nature.': [2291, 2704], '416:': [2293], '507-511Crossref': [2294], '(2034)': [2297], '57Burdick': [2300], 'Soreghan': [2302, 3030], 'Kwon': [2304, 3032], 'Knauer': [2308, 3036], 'Henschen': [2310, 3038], 'Yates': [2312, 3040], '1992;': [2321, 3049], '267:': [2322, 3050], '546-554Abstract': [2323, 3051], 'At': [2330], 'longer': [2331], 'times,': [2333], 'curvilinear': [2334], 'beaded': [2340], 'appearance.': [2341], 'structures': [2343], 'called': [2347], '"protofibrils,"': [2348], 'formed': [2354], 'coalescence': [2357], 'subunits': [2361], 'specifically': [2386, 2682, 2964, 2969], 'recognized': [2387, 2683], 'polyclonal': [2390], 'antibody,': [2391, 2923], 'A11,': [2392, 2924], '3Nomenclature': [2393], 'follows.': [2396], 'A11': [2397, 2583, 2620, 2643, 2685, 2778, 2826, 3097], 'anti-oligomer-specific': [2400], 'antibody': [2401, 2687, 2827, 3099], '(58Kayed': [2402, 2560, 2597], 'Head': [2404, 2562, 2599], 'Thompson': [2406, 2564, 2601], 'J.L.': [2407, 2565, 2602, 3829], 'McIntire': [2408, 2566, 2603], 'T.M.': [2409, 2567, 2604], 'Milton': [2410, 2568, 2605], 'S.C.': [2411, 2569, 2606], '300:': [2418, 2576, 2613], '486-489Crossref': [2419, 2577, 2614], '(3228)': [2422, 2580, 2617], 'Inhibition': [2425], 'refers': [2428, 2440], 'inhibition': [2430], 'A11-immunoreactive': [2434, 2449], 'oligomers.': [2435, 2450, 2477, 2541], 'An': [2436], 'inhibits': [2445], '"Oligomerization': [2451], 'conditions"': [2452, 2462], 'refer': [2453, 2463], 'conditions': [2455, 2465, 2479, 2482, 2493, 2508, 2536], 'favor': [2457, 2467], 'A11-reactive': [2458], 'visualization.': [2460], '"Fibrillization': [2461], 'absence': [2472], 'contamination': [2474], 'A11-positive': [2476], 'Fibrillization': [2478], 'nomenclature': [2485, 2522], 'sole': [2489], 'purpose': [2490], 'describing': [2492], 'where': [2494], 'Aβ42': [2495, 3022, 3188], 'forms': [2496], 'oligomer-free': [2497], 'fiber-free': [2500], '(at': [2502], 'points),': [2505], 'respectively.': [2506], 'allow': [2509], 'separate': [2510, 2992], 'screening': [2511, 3002], 'effects': [2513], 'meant': [2525], 'best': [2532], 'only': [2535], 'prepare': [2538], 'recognizes': [2543, 2828], 'generic': [2545], 'backbone': [2546], 'epitope': [2547], 'common': [2550], 'oligomeric': [2553, 2662], 'state': [2554], 'independent': [2555], 'sequence': [2559], 'does': [2584], 'recognize': [2586], 'dimer,': [2590], 'trimer,': [2591], 'tetramer': [2593], 'positive': [2621], 'kinetics': [2627], 'protofibrils': [2634], 'blocks': [2644], 'oligomers,': [2649, 2966], 'indicating': [2650], 'species.': [2657], 'Aβ*56': [2658, 2680], 'closely': [2668], 'pathogenesis': [2671], 'Tg2576': [2674], 'mouse': [2675, 2794], 'model': [2676], 'anti-oligomer': [2686, 2922, 3098], '(59Lesne': [2688], 'Koh': [2690], 'M.T.': [2691], 'Kotilinek': [2692], 'Kayed': [2694, 3550], 'Yang': [2698], 'Gallagher': [2700], 'Ashe': [2702], '440:': [2706], '352-357Crossref': [2707], '(2279)': [2710], 'were': [2715, 3062, 3075, 3083, 3119, 3136, 3148, 3179], 'originally': [2716], 'molecular': [2720], 'weight': [2721], 'trimeric': [2722], 'tetrameric': [2724], 'species,': [2725], 'investigations': [2728], 'native': [2731], 'masses': [2732], 'previously': [2739, 3026, 3163], 'Aβ-soluble': [2743], '(60Hepler': [2745], 'R.W.': [2746], 'Grimm': [2747], 'K.M.': [2748], 'Nahas': [2749], 'D.D.': [2750], 'Breese': [2751], 'Dodson': [2753], 'E.C.': [2754], 'Acton': [2755], 'Keller': [2757], 'Yeager': [2759], 'Wang': [2761], 'Shughrue': [2763], 'Kinney': [2765], 'Joyce': [2767], '45:': [2771], '15157-15167Crossref': [2772], '(157)': [2775], 'anti-ADDL': [2780], 'antibodies': [2781, 3118], 'identify': [2782, 3017], 'course': [2786], 'accumulation': [2790], '3xTg-AD': [2793], '(61Oddo': [2795], 'Caccamo': [2797], 'Tran': [2799], 'Lambert': [2801], 'LaFerla': [2807], 'F.M.': [2808], '281:': [2813], '1599-1604Abstract': [2814], '(339)': [2822], 'important': [2832], 'class': [2833], 'Analysis': [2845], 'holds': [2855], 'promise': [2857], 'relationship': [2861], 'between': [2862], 'fibrils,': [2865], 'if': [2867, 2895], 'then': [2878, 2903], 'all': [2879, 3145], 'block': [2882, 2889, 2912], 'would': [2885, 2905, 2911], 'expected': [2887, 2907], 'well.': [2893], 'Alternatively,': [2894], 'pathways,': [2902], 'Here': [2918], 'utilize': [2920], 'read': [2928], 'out': [2929], 'analyze': [2935], 'proteins': [2954], 'toxicity.': [2957], 'The': [2958, 2997, 3153], 'demonstrate': [2960], 'whereas': [2967], 'others': [2968], 'pathways.': [2996], 'further': [2999], 'using': [3006], 'fibril-specific': [3007], 'assays,': [3008], 'like': [3009], 'T': [3011], '(ThT)': [3012], 'fluorescence,': [3013], 'will': [3014], 'necessarily': [3016], 'oligomerization.': [3020], 'Materials—Synthetic': [3021], 'prepared': [3024], '(57Burdick': [3028], '200-mesh': [3058], 'formvar/carbon-coated': [3059], 'nickel': [3060], 'grids': [3061], 'obtained': [3063], 'Microscopy': [3066], 'Sciences': [3067], '(Ft.': [3068], 'Washington,': [3069], 'PA),': [3070], '4–20%': [3072], 'Tris-HCl': [3073], 'gels': [3074], 'Bio-Rad.': [3077], '96-well': [3078], 'clear,': [3079], 'flat': [3080], 'bottom': [3081], 'microplates': [3082], 'Nalge': [3085], 'Nunc': [3086], 'International': [3087], '(Rochester,': [3088], 'NY),': [3089], '3,3′,5,5′-tetramethylbenzidine': [3091], 'KPL': [3094], '(Gaithersburg,': [3095], 'MD).': [3096], 'available': [3101], 'Invitrogen.': [3103], 'Horseradish': [3104], 'peroxidase-conjugated': [3105], 'IgG': [3107], '(AR)': [3108], 'purchased': [3110], 'Promega': [3112], '(Madison,': [3113], 'WI),': [3114], '6E10': [3115], '4G8': [3117], 'Signet': [3121], '(Dedham,': [3122], 'MA),': [3123], 'ECL': [3126], 'chemiluminescence': [3127], 'kit': [3128], 'Amersham': [3131], 'Biosciences.': [3132], '0.2-μm': [3133], 'nitrocellulose': [3134], 'membranes': [3135], 'Schleicher': [3138], '&': [3139], 'Schuell.': [3140], 'Small': [3141], 'reagents': [3147], 'Sigma': [3150], 'Calbiochem.': [3152], 'following': [3154], 'analogs': [3158], 'bind': [3165], 'modulate': [3169], 'and/or': [3172], 'screened': [3175], 'such': [3177], 'activities': [3178], 'tested': [3180], 'here': [3181], 'separately': [3182], 'ability': [3185], 'formation:': [3192], 'apigenin': [3193], '(62Taniguchi': [3194, 3226, 3259, 3626, 3680, 3728, 3777, 3864, 3948, 4110, 4141, 4330], 'Suzuki': [3196, 3228, 3261, 3628, 3682, 3730, 3779, 3866, 3950, 4112, 4143, 4201, 4332], 'Masuda': [3198, 3230, 3263, 3630, 3684, 3732, 3781, 3868, 3952, 4114, 4145, 4203, 4334], 'Hisanaga': [3200, 3232, 3265, 3632, 3686, 3734, 3783, 3870, 3954, 4116, 4147, 4205, 4336], 'Iwatsubo': [3202, 3234, 3267, 3634, 3688, 3736, 3785, 3872, 3956, 4118, 4149, 4207, 4338], 'Goedert': [3204, 3236, 3269, 3636, 3690, 3738, 3787, 3874, 3958, 4120, 4151, 4209, 4340], '7614-7623Abstract': [3213, 3245, 3278, 3645, 3699, 3747, 3796, 3883, 3967, 4129, 4160, 4218], '(405)': [3221, 3253, 3286, 3653, 3707, 3755, 3804, 3891, 3975, 4137, 4168, 4226], 'azure': [3224], 'C': [3225], 'basic': [3256], 'blue': [3257, 3321], '41': [3258], 'trans)-1-bromo-2,5-bis-(3-hydroxycarbonyl-4-hydroxy)styrylbenzene': [3290], '(BSB)': [3291], '(63Skovronsky': [3292], 'Kung': [3296, 3298], 'H.F.': [3299], 'Trojanowski': [3300], 'J.Q.': [3301], '97:': [3312, 3452], '7609-7614Crossref': [3313], 'Chicago': [3319], 'sky': [3320], '6B': [3322], '(25Pollack': [3323, 3659, 4058], 'Congo': [3343], 'red': [3344, 3657, 4260], '(10Kuner': [3345], '64Podlisny': [3403], 'M.B.': [3404], 'Walsh': [3405], 'Amarante': [3407], 'Ostaszewski': [3409], 'B.L.': [3410], 'Stimson': [3411], 'E.R.': [3412], 'Maggio': [3413], '37:': [3421], '3602-3611Crossref': [3422], '(181)': [3425], '65Heiser': [3428], 'Scherzinger': [3430], 'Boeddrich': [3432], 'Nordhoff': [3434], 'Lurz': [3436], 'Schugardt': [3438], 'Lehrach': [3440], 'Wanker': [3442], 'E.E.': [3443, 3462, 3827], '6739-6744Crossref': [3453], '(244)': [3456], '66Chirita': [3459], 'C.N.': [3460], 'Congdon': [3461], 'Yin': [3463], 'Kuret': [3465], '44:': [3469], '5862-5872Crossref': [3470], 'β-cyclodextrin': [3476], '(67Camilleri': [3477], 'Haskins': [3479], 'N.J.': [3480], 'Howlett': [3481], 'FEBS': [3483, 3766, 3815], '341:': [3486], '256-258Crossref': [3487], '68Yu': [3493], 'Bakhos': [3495], 'Holterman': [3499], 'Venton': [3503], 'D.L.': [3504], '19:': [3509, 3837], '51-55Crossref': [3510], '(27)': [3513], 'curcumin': [3516], '(11Ono': [3517, 4007], '69Yang': [3536], 'Lim': [3538], 'G.P.': [3539], 'Begum': [3540], 'A.N.': [3541], 'Ubeda': [3542], 'O.J.': [3543], 'Simmons': [3544], 'Ambegaokar': [3546], 'P.P.': [3549], 'Frautschy': [3554], 'S.A.': [3555], 'Cole': [3556], 'G.M.': [3557], '5892-5901Abstract': [3563], '(1755)': [3571], 'daunomycin': [3574], 'hydrochloride': [3575], '(15Howlett': [3576, 4279], 'dimethyl': [3624], 'yellow': [3625], 'direct': [3656], '80': [3658], '2,2′-dihydroxybenzophenone': [3679], 'bromide': [3711], '(C16)': [3712], 'hemin': [3726], 'chloride': [3727], '70Howlett': [3758, 3807], 'Cutler': [3760, 3809], 'Heales': [3762, 3811], '417:': [3769, 3818], '249-251Crossref': [3770, 3819], '(96)': [3773, 3822], 'hematin': [3776], 'indomethacin': [3825], '(71Netland': [3826], 'Newton': [3828], 'Majocha': [3830], 'Tate': [3832], 'Neurobiol.': [3834], 'Aging.': [3835], '201-204Crossref': [3838], 'juglone': [3844], '(72Wang': [3845, 3896], 'Gines': [3847, 3898], 'MacDonald': [3849, 3900], 'M.E.': [3850, 3901], 'Gusella': [3851, 3902], 'J.F.': [3852, 3903], 'BMC': [3853, 3904], '1-12Crossref': [3857, 3908], '(94)': [3860, 3911], 'lacmoid': [3863], 'meclocycline': [3894], 'sulfosalicylate': [3895], 'melatonin': [3914], '(18Pappolla': [3915], 'myricetin': [3947], '1,2-naphthoquinone': [3978], '(16Tomiyama': [3979, 4173], 'nordihydroguaiaretic': [4005], 'acid': [4006], 'R(–)-norapomorphine': [4026], 'hydrobromide': [4027], '(19Lashuel': [4028], 'orange': [4056], 'G': [4057], 'o-vanillin': [4078], '(2-hydroxy-3-methoxybenzaldehyde)': [4079], '(24De': [4080], 'pherphenazine': [4109], 'phthalocyanine': [4140], 'rifamycin': [4171], 'SV': [4172], '62Taniguchi': [4199], '73Tomiyama': [4229], 'Shoji': [4231], 'Kaneko': [4239], '6839-6844Abstract': [4248], '(279)': [4256], 'phenol': [4259], '(74Porat': [4261], 'Mazor': [4263], 'Efrat': [4265], 'Gazit': [4267], '14454-14462Crossref': [4272], '(176)': [4275], 'rolitetracycline': [4278], 'quinacrine': [4327], 'mustard': [4328], 'dihydrochloride': [4329], '7614-7623Abstr': [4349]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2050146983', 'counts_by_year': [{'year': 2024, 'cited_by_count': 9}, {'year': 2023, 'cited_by_count': 16}, {'year': 2022, 'cited_by_count': 17}, {'year': 2021, 'cited_by_count': 22}, {'year': 2020, 'cited_by_count': 33}, {'year': 2019, 'cited_by_count': 19}, {'year': 2018, 'cited_by_count': 33}, {'year': 2017, 'cited_by_count': 33}, {'year': 2016, 'cited_by_count': 47}, {'year': 2015, 'cited_by_count': 40}, {'year': 2014, 'cited_by_count': 51}, {'year': 2013, 'cited_by_count': 46}, {'year': 2012, 'cited_by_count': 68}], 'updated_date': '2024-12-12T08:06:56.874581', 'created_date': '2016-06-24'}