Hypothyroid Phenotype Is Contributed by Mitochondrial Complex I Inactivation Due to Translocated Neuronal Nitric-oxide Synthase

Name: Work Video:
Duration: 3 min 30 s
María Clara Franco; Valeria G. Antico Arciuch; Jorge G. Peralta; Soledad Galli; Damián M. Levisman; Lidia M. López; Leonardo Romorini; Juan José Poderoso; Marı́a C. Carreras
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'abstract_inverted_index': {'Although': [0, 212, 527], 'transcriptional': [1, 213, 530, 572], 'effects': [2, 47, 214, 259, 460, 531, 603, 3897, 3916, 4050, 4103], 'of': [3, 22, 125, 206, 215, 234, 337, 418, 503, 506, 553, 571, 575, 580, 604, 674, 765, 770, 874, 1101, 1138, 1205, 1211, 1226, 1236, 1250, 1336, 1372, 1462, 1468, 1510, 1572, 1586, 1613, 1619, 1621, 1642, 1648, 1651, 1673, 1719, 1755, 1809, 1977, 1981, 2013, 2035, 2050, 2170, 2205, 2325, 2361, 2369, 2381, 2401, 2406, 2562, 2573, 2591, 2618, 2664, 2728, 2815, 2872, 2960, 3048, 3056, 3071, 3098, 3174, 3233, 3336, 3376, 3457, 3481, 3558, 3590, 3601, 3640, 3647, 3659, 3735, 3748, 3829, 3841, 3853, 3898, 3913, 3917, 3951, 3978, 4061, 4120, 4211, 4215], 'thyroid': [4, 13, 46, 80, 155, 160, 207, 216, 225, 258, 292, 367, 372, 419, 499, 547, 849, 1427, 3717, 4102], 'hormones': [5, 217, 500, 548], 'have': [6, 218, 532], 'substantial': [7, 219], 'influence': [8, 220, 501], 'on': [9, 48, 221, 260, 535, 1209, 1247, 2108, 3018, 3153, 3716, 3922, 3930, 4051, 4104], 'oxidative': [10, 222, 536], 'metabolism,': [11, 223], 'how': [12, 224, 546], 'sets': [14, 226], 'basal': [15, 169, 227, 381, 628, 3923, 4209], 'metabolic': [16, 50, 170, 228, 262, 382, 551, 629, 3732], 'rate': [17, 229, 438, 552, 2650, 2733, 3232, 3382, 3440, 3733, 4070], 'remains': [18, 230], 'obscure.': [19, 231], 'Compartmental': [20, 232], 'localization': [21, 233, 673], 'nitric-oxide': [23, 36, 103, 162, 235, 248, 315, 374, 625, 772, 780], 'synthases': [24, 236], 'is': [25, 201, 237, 413, 425, 542, 681, 1230, 1308, 3230, 4026, 4205, 4222], 'important': [26, 238, 683, 3650], 'for': [27, 45, 239, 257, 686, 1378, 1575, 1606, 1624, 1654, 1671, 1859, 1930, 1940, 1969, 2042, 2053, 2058, 2063, 2099, 2250, 2415, 2522, 2924, 2994, 3104, 4036], 'nitric': [28, 240, 605, 613, 675, 3720], 'oxide': [29, 241, 606, 3721], 'signaling.': [30, 242], 'We': [31, 193, 243, 405, 4056], 'therefore': [32, 244], 'examined': [33, 245, 4058], 'liver': [34, 246, 925, 1821, 3114, 3377, 3528, 3581, 3596], 'neuronal': [35, 247, 771], 'synthase-α': [37, 249, 773], '(nNOS)': [38, 250, 774], 'subcellular': [39, 251, 672, 2167, 3576], 'distribution': [40, 252, 3577], 'as': [41, 253, 1423, 1771, 1865, 2084, 2560, 2603, 2653, 2662, 2749, 2758, 2837, 3120, 3220, 3268, 3311, 3385, 3443, 3668, 4170], 'a': [42, 202, 254, 414, 426, 504, 766, 842, 1561, 1711, 1978, 2090, 2095, 2316, 2323, 2382, 2391, 2479, 2610, 3555, 3866, 4013, 4132], 'putative': [43, 255], 'mechanism': [44, 256, 685], 'rat': [49, 261, 4138], 'rate.': [51, 263], 'At': [52, 264, 1089, 1198, 3476], 'low': [53, 107, 265, 319, 431, 435, 837, 3477], '3,3′,5-triiodo-l-thyronine': [54, 266], 'levels,': [55, 267], 'nNOS': [56, 66, 89, 97, 196, 268, 278, 301, 309, 408, 1379, 1515, 1970, 2085, 2320, 3085, 3482, 3499, 3515, 3547, 3592, 3613, 3654, 3675, 3870, 4025], 'mRNA': [57, 83, 269, 295, 3516, 3538], 'increased': [58, 115, 168, 270, 327, 380, 3525, 3638, 3686, 3957, 4142], 'by': [59, 63, 271, 275, 1098, 1233, 1313, 1505, 1545, 1582, 1627, 1677, 1806, 2046, 2077, 2203, 2348, 2570, 2587, 2623, 2637, 2877, 2903, 3091, 3334, 3373, 3489, 3508, 3519, 3569, 3595, 3670, 4006, 4012], '3-fold,': [60, 272], 'protein': [61, 141, 182, 273, 353, 394, 652, 902, 2407, 2665, 3176, 3501, 3625, 3643], 'expression': [62, 188, 274, 400, 3517, 3593, 3614, 3639], 'one-fold,': [64, 276], 'and': [65, 88, 119, 122, 143, 149, 175, 179, 185, 209, 277, 300, 331, 334, 355, 361, 387, 391, 397, 421, 434, 508, 538, 618, 623, 926, 1013, 1042, 1052, 1134, 1141, 1201, 1383, 1392, 1438, 1459, 1465, 1482, 1516, 1529, 1552, 1566, 1657, 1728, 1753, 1765, 1769, 1814, 1827, 1861, 1935, 1961, 1994, 2017, 2033, 2094, 2102, 2151, 2154, 2200, 2245, 2265, 2271, 2338, 2375, 2427, 2431, 2441, 2470, 2565, 2599, 2660, 2730, 2794, 2803, 2817, 2827, 2870, 2898, 2968, 2992, 3003, 3013, 3068, 3102, 3106, 3111, 3156, 3159, 3248, 3256, 3257, 3262, 3309, 3317, 3324, 3329, 3466, 3469, 3491, 3503, 3598, 3719, 3880, 3886, 3920, 3965, 4010, 4029, 4039, 4054, 4091, 4118, 4140], 'was': [67, 134, 279, 346, 1375, 1503, 1543, 1705, 1803, 1823, 1829, 1945, 1972, 2068, 2074, 2162, 2183, 2196, 2313, 2346, 2433, 2475, 2554, 2585, 2621, 2635, 2651, 2734, 2808, 2943, 3089, 3115, 3187, 3304, 3331, 3371, 3441, 3459, 3487, 3523, 3634, 3666, 3684, 3691, 3709, 3956, 4004, 4074, 4086, 4095], 'selectively': [68, 280], 'translocated': [69, 281, 4024], 'to': [70, 137, 154, 190, 282, 349, 366, 402, 430, 458, 583, 665, 775, 788, 848, 990, 1221, 1311, 1322, 1376, 1381, 1426, 2070, 2113, 2179, 2185, 2207, 2799, 2821, 2946, 2981, 3190, 3260, 3562, 3618, 3636, 3653, 3693, 3875, 4043, 4064], 'mitochondria': [71, 200, 283, 412, 776, 1382, 1766, 2239, 2508, 2796, 3378, 3552, 3689, 3900, 4030], 'without': [72, 158, 284, 370], 'changes': [73, 285], 'in': [74, 93, 100, 199, 286, 305, 312, 411, 762, 838, 1043, 1329, 1386, 1560, 1603, 1634, 1637, 1710, 1725, 1761, 1952, 1984, 2026, 2192, 2198, 2242, 2268, 2273, 2308, 2327, 2335, 2355, 2378, 2390, 2412, 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[106, 318, 569, 678, 1224, 1320, 1564, 1721, 1825, 1947, 1956, 1974, 1988, 2146, 2156, 2164, 2174, 2258, 2340, 2350, 2421, 2435, 2478, 2511, 2556, 2595, 2609, 2916, 2930, 2965, 2971, 3010, 3040, 3053, 3163, 3461, 3530, 3673, 3699, 3903, 4125, 4213], 'O2': [108, 117, 320, 329, 1040, 1054, 1096, 1206, 1387, 2468, 2552, 3745, 3888, 3924, 3954, 3979, 4052, 4066, 4126], 'uptake.': [109, 321, 4067], 'this': [111, 323, 670, 1373, 3497, 3621], 'context,': [112, 324, 671, 3498], 'NO': [113, 325, 687, 787, 1047, 1093, 1234, 1321, 1331, 2506, 3369, 3973, 4049], 'utilization': [114, 326, 433, 3925], 'active': [116, 328, 1338, 2568, 4028], 'species': [118, 330, 1207, 1339], 'peroxynitrite': [120, 332, 1324], 'yields': [121, 333], 'tyrosine': [123, 335], 'nitration': [124, 174, 336, 386, 903], 'complex': [126, 131, 176, 338, 343, 388, 2370, 2563, 2983, 3095, 4072, 4092, 4216], 'I': [127, 177, 339, 389, 1200, 1464, 2371, 2564, 2580, 2739, 2793, 2984, 3060, 3827, 4073, 4217], 'proteins': [128, 340, 3050], 'that': [129, 195, 341, 407, 1243, 2073, 4022, 4208], 'reduced': [130, 342, 1218, 3695], 'activity.': [132, 344], 'Hypothyroidism': [133, 345, 424], 'also': [135, 347, 2075], 'associated': [136, 348, 429, 847, 3652], 'high': [138, 350, 3611], 'phospho-p38': [139, 351], 'mitogen-activated': [140, 181, 352, 393, 651], 'kinase': [142, 147, 183, 354, 359, 395], 'decreased': [144, 356, 4011, 4076, 4133], 'phospho-extracellular': [145, 357], 'signal-regulated': [146, 358, 656], '1/2': [148, 360], 'cyclin': [150, 186, 362, 398, 1530, 1931, 3112, 3157], 'D1': [151, 187, 363, 399, 1531, 3158], 'levels.': [152, 364], 'Similarly': [153, 365], 'hormones,': [156, 368], 'but': [157, 369, 841, 3620, 3690], 'changing': [159, 371], 'status,': [161, 373], 'inhibitor': [164, 376, 3909, 3921], 'Nω-nitro-l-arginine': [165, 377, 643, 1434], 'methyl': [166, 378, 644, 1435], 'ester': [167, 379, 1436], 'rate,': [171, 383, 4128], 'prevented': [172, 384], 'derangement,': [178, 390], 'turned': [180, 392], 'signaling': [184, 396, 688], 'back': [189, 401], 'control': [191, 403, 1658, 2093, 2365, 2377], 'pattern.': [192, 404], 'surmise': [194, 406], 'spatial': [197, 409], 'confinement': [198, 410, 4042], 'significant': [203, 415, 4101], 'downstream': [204, 416], 'effector': [205, 417, 679], 'hypothyroid': [210, 422, 3527, 3607, 3688, 3960, 4078], 'phenotype.': [211, 423], 'prevalent': [427], 'disorder': [428], 'oxygen': [432], 'tissue': [436], 'proliferation': [437], '(1Moro': [439], 'L.': [440, 735, 1844, 1880], 'Marra': [441], 'E.': [442, 817, 970, 1179, 1286, 1351, 2707, 3419], 'Capuano': [443], 'F.': [444, 1000, 1120, 1154, 1173, 1261, 1280, 1345, 1739, 3395, 3413, 3990], 'Greco': [445], 'M.': [446, 936, 960, 1402, 1780, 1895, 2124, 2216, 2283, 2444, 2673, 2697, 2767, 2846, 3129, 3199, 3278, 3347, 4173, 4175], 'Endocrinology.': [447, 1849, 1885], '2004;': [448, 491, 560, 745, 917, 949, 1030, 1415, 1694, 1793, 2137, 2229, 2296, 2686, 2780, 2859, 3142, 3212, 3291, 3360], '145:': [449], 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1751, 1800, 1857, 2236, 2303, 2466, 2503, 2549, 2725, 2787, 2866, 2895, 2958, 3036, 3149, 3298, 3367, 3437, 3947, 4203], 'addition': [457, 2572], 'non-genomic': [459], '(2Scanlan': [461], 'T.S.': [462], 'Suchland': [463], 'K.L.': [464], 'Hart': [465], 'M.E.': [466], 'Chiellini': [467], 'G.': [468, 3026, 4177], 'Huang': [469, 711], 'Y.': [470, 739, 1840, 1876], 'Kruzich': [471], 'P.J.': [472], 'Frascarelli': [473], 'S.': [474, 480, 731, 945, 1020, 1061, 1411, 1789, 2133, 2225, 2292, 2682, 2776, 2855, 3138, 3208, 3287, 3356, 4153], 'Crossley': [475], 'D.A.': [476], 'Bunzow': [477], 'J.R.': [478, 1070], 'Ronca-Testoni': [479], 'Lin': [481], 'E.T.': [482], 'Hatton': [483], 'D.': [484, 727, 998, 1737, 3393], 'Zucchi': [485], 'R.': [486, 729, 4150], 'Grandy': [487], 'D.K.': [488], 'Nat.': [489, 558], 'Med.': [490, 559, 593, 1029], '10:': [492, 561], '638-642Crossref': [493], '(374)': [496], 'Scholar),': [498, 872, 900, 924, 988, 1012, 2144, 4164], 'transcription': [502], 'number': [505], 'nuclear': [507], 'mitochondrial-encoded': [509], 'respiratory': [510, 1045, 3381], 'genes': [511], '(3Pillar': [512], 'T.M.': [513], 'Seitz': [514], 'H.J.': [515], 'Eur.': [516], 'J.': [517, 592, 733, 742, 798, 866, 885, 915, 973, 1006, 1022, 1073, 1182, 1289, 1354, 1745, 1921, 2497, 2543, 2710, 2885, 3401, 3422], 'Endocrinol.': [518, 4156, 4180], '1997;': [519], '136:': [520], '231-239Crossref': [521], '(108)': [524, 755], 'direct': [528], 'or': [529, 782, 1239, 1318, 2517, 2740, 2745, 2920, 3063, 3536, 3906, 4108, 4219], 'considerable': [533], 'impact': [534], 'metabolism': [537], 'hemodynamic': [539], 'function,': [540], 'much': [541], 'still': [543], 'unknown': [544], 'about': [545], 'set': [549], 'the': [550, 554, 585, 599, 602, 662, 666, 763, 789, 1136, 1245, 1248, 1334, 1370, 1583, 1587, 1638, 1665, 1667, 2081, 2157, 2165, 2171, 2180, 2187, 2359, 2362, 2379, 2571, 2588, 2648, 2654, 2982, 3092, 3231, 3374, 3559, 3563, 3579, 3588, 3599, 3602, 3606, 3624, 3637, 3648, 3663, 3884, 3896, 3914, 4034, 4044, 4059], 'body': [555, 1622, 1652], '(4Liggett': [556], 'S.B.': [557], '582-583Crossref': [562], '(13)': [565], 'Scholar);': [567, 1369], 'consonant': [568], 'slowness': [570], 'mechanisms,': [573], 'treatment': [574, 1615], 'hypothyroidism': [576, 4009, 4139], 'may': [577], 'require': [578], 'weeks': [579], 'administration': [582], 'normalize': [584], 'altered': [586], 'functions': [587], '(5Toft': [588], 'A.D.': [589], 'New': [590], 'Engl.': [591], '1994;': [594], '331:': [595], '171-180Google': [596], 'last': [600, 1639], 'decade,': [601], '(NO)': [607, 3816], '2The': [608], 'abbreviations': [609], 'used': [610, 2184], 'are:': [611], 'NO,': [612], 'oxide;': [614], 'nNOS,': [615, 1526, 1991], 'eNOS,': [616], 'iNOS,': [617, 1527], 'mtNOS,': [619, 3899], 'neuronal,': [620], 'endothelial,': [621], 'inducible,': [622], 'synthase;': [626], 'BMR,': [627, 3876], 'rate;': [630], 'T3,': [631, 3478, 3612], '3,3′,5-triiodo-l-thyronine;': [632], 'Mn-SOD,': [633, 2825, 4106], 'manganese': [634, 1314], 'superoxide': [635, 1139, 1315], 'dismutase;': [636], 'CAT,': [637], 'catalase;': [638], 'GPX,': [639], 'glutathione': [640, 2828, 3263, 4109], 'peroxidase;': [641], 'l-NAME,': [642], 'esther;': [645], 'Hsp,': [646], 'heat': [647, 3641], 'shock': [648, 3642], 'protein;': [649], 'MAPK,': [650], 'kinase;': [653, 657], 'ERK,': [654], 'extracellular': [655], 'l-NMMA,': [658], 'l-NG-methyl-l-arginine.': [659], 'expanded': [660], 'from': [661, 1217, 1443, 1474, 1486, 1494, 1521, 1534, 2987, 3306, 3878, 3975], 'vascular': [663], 'system': [664, 1715], 'intracellular': [667], 'milieu.': [668], 'oxide-synthases': [676], '(NOS)': [677], 'molecules': [680], 'an': [682, 1722, 2036, 2436, 2752, 3700, 4141], 'regulatory': [684], '(6Barouch': [689], 'L.A.': [690], 'Harrison': [691], 'R.W.': [692], 'Skaf': [693], 'M.W.': [694], 'Rosas': [695], 'G.O.': [696], 'Cappola': [697], 'T.P.': [698], 'Kobeissi': [699], 'Z.A.': [700], 'Hobai': [701], 'I.A.': [702], 'Lemmon': [703], 'C.A.': [704], 'Burnett': [705], 'A.L.': [706], "O'Rourke": [707], 'B.': [708, 1688], 'Rodriguez': [709], 'E.R.': [710], 'P.L.': [712], 'Lima': [713], 'J.A.': [714], 'Berkowitz': [715], 'D.E.': [716], 'Hare': [717], 'J.M.': [718], 'Nature.': [719], '2002;': [720, 976, 1850, 1886, 2713], '416:': [721], '337-339Crossref': [722], 'Scholar,': [725, 813, 956, 1167, 1274, 1893, 1911, 2693, 3407, 4188], '7Fulton': [726], 'Babbitt': [728], 'Zoellner': [730], 'Fontana': [732], 'Acevedo': [734], 'McCabe': [736], 'T.J.': [737], 'Iwakiri': [738], 'Sessa': [740], 'W.C.': [741], 'Biol.': [743, 799, 886, 974, 1074, 1183, 1290, 1355, 2711, 2887, 2952, 3423], 'Chem.': [744, 800, 887, 975, 1075, 1184, 1291, 1356, 2712, 3424], '279:': [746], '30349-30357Abstract': [747], 'Full': [748, 750, 804, 806, 824, 826, 891, 893, 979, 981, 1079, 1081, 1188, 1190, 1295, 1297, 1360, 1362, 2716, 2718, 3428, 3430], 'Text': [749, 751, 805, 807, 825, 827, 892, 894, 980, 982, 1080, 1082, 1189, 1191, 1296, 1298, 1361, 1363, 2717, 2719, 3429, 3431], 'PDF': [752, 808, 828, 895, 983, 1083, 1192, 1299, 1364, 2720, 3432], 'Accordingly,': [758], 'we': [759], 'are': [760, 3451], 'interested': [761], 'traffic': [764, 1380], 'posttranslationally': [767], 'modified': [768, 2913, 4097], 'variant': [769], '(formerly': [777], 'named': [778], 'mtNOS),': [783], 'which': [784], 'vectorially': [785], 'directs': [786], 'matrix': [790, 1092, 1330, 3815, 3972], 'compartment': [791, 4047], '(8Giulivi': [792], 'C.': [793, 884, 913, 1116, 1150, 1171, 1257, 1278, 1343, 1690, 1836, 1838, 1872, 1874, 2446, 3411, 3986], 'Poderoso': [794, 863, 946, 971, 1003, 1412, 1742, 1790, 2134, 2226, 2293, 2494, 2540, 2683, 2708, 2777, 2856, 3139, 3209, 3288, 3357, 3398], 'J.J.': [795, 864, 947, 972, 1004, 1112, 1146, 1169, 1253, 1276, 1341, 1413, 1743, 1791, 2135, 2227, 2294, 2495, 2541, 2684, 2709, 2778, 2857, 3140, 3210, 3289, 3358, 3399, 3409, 3982], 'Boveris': [796, 1025, 1121, 1155, 1180, 1262, 1287, 1352, 3420, 3936, 3991], 'A.': [797, 911, 940, 1026, 1122, 1156, 1181, 1263, 1288, 1353, 1406, 1784, 2128, 2220, 2287, 2677, 2771, 2850, 3133, 3203, 3282, 3351, 3421, 3937, 3992], '1998;': [801], '273:': [802], '11038-11043Abstract': [803], '(514)': [811], '9Ghafourifar': [814], 'P.': [815, 878, 1686, 1846, 1882, 1913, 4147], 'Cadenas': [816, 969, 1178, 1285, 1350, 2706, 3418], 'Trends': [818], 'Pharmacol.': [819], 'Sci.': [820], '2005;': [821, 3940], '26:': [822], '190-195Abstract': [823], '(331)': [831], 'mtNOS': [834, 3484, 3660, 3927], 'could': [835], 'be': [836], 'adult': [839], 'rodents,': [840], 'modulated': [843, 3507], 'increase': [844, 3589], 'has': [845], 'been': [846], 'status': [850, 3486, 3718, 4079], '(10Carreras': [851, 2482, 2528], 'M.C.': [852, 930, 966, 968, 1002, 1065, 1114, 1148, 1177, 1255, 1284, 1349, 1396, 1741, 1774, 2118, 2210, 2277, 2483, 2529, 2667, 2703, 2705, 2761, 2840, 3123, 3193, 3272, 3341, 3397, 3417, 3984], 'Peralta': [853, 2484, 2530], 'J.G.': [854, 994, 1733, 2485, 2531, 3389], 'Converso': [855, 931, 997, 1397, 1736, 1775, 2119, 2211, 2278, 2486, 2532, 2668, 2762, 2841, 3124, 3194, 3273, 3342, 3392], 'D.P.': [856, 932, 1398, 1776, 2120, 2212, 2279, 2487, 2533, 2669, 2763, 2842, 3125, 3195, 3274, 3343], 'Finocchietto': [857, 995, 1734, 2488, 2534, 3390], 'P.V.': [858, 996, 1735, 2489, 2535, 3391], 'Rebagliati': [859, 2490, 2536], 'I.': [860, 2491, 2537], 'Zaninovich': [861, 2492, 2538], 'A.A.': [862, 2493, 2539], 'Am.': [865, 914, 1005, 1744, 2496, 2542, 3400], 'Physiol.': [867, 916, 1007, 1746, 2498, 2544, 3402], '2001;': [868, 2499, 2545, 2953, 4196], '281:': [869, 2500, 2546], 'H2282-H2288PubMed': [870, 2501, 2547], 'release': [873], 'cytochrome': [875, 1102, 1222, 1237, 1240, 2624, 2639, 2805, 3337, 4084], 'c': [876, 1816, 2625, 2640, 2806, 3338], '(11Ghafourifar': [877], 'Schenk': [879], 'U.': [880], 'Klein': [881], 'S.D.': [882], 'Richter': [883], '1999;': [888, 1185, 1292, 1357, 3425], '274:': [889, 1186, 1293, 1358, 3426], '31185-31188Abstract': [890], '(311)': [898], '(12Elfering': [904], 'S.L.': [905], 'Haynes': [906], 'V.L.': [907], 'Traaseth': [908], 'N.J.': [909], 'Ettl': [910], 'Giulivi': [912], '286:': [918], 'H22-H29Crossref': [919], '(96)': [922], 'brain': [927], 'development': [928], '(13Carreras': [929, 1395, 1773, 2117, 2209, 2276, 2666, 2760, 2839, 3122, 3271, 3340], 'Lorenti': [933, 1399, 1777, 2121, 2213, 2280, 2670, 2764, 2843, 3126, 3196, 3275, 3344], 'A.S.': [934, 1400, 1778, 2122, 2214, 2281, 2671, 2765, 2844, 3127, 3197, 3276, 3345], 'Barbich': [935, 1401, 1779, 2123, 2215, 2282, 2672, 2766, 2845, 3128, 3198, 3277, 3346], 'Levisman': [937, 1403, 1781, 2125, 2217, 2284, 2674, 2768, 2847, 3130, 3200, 3279, 3348], 'D.M.': [938, 1404, 1782, 2126, 2218, 2285, 2675, 2769, 2848, 3131, 3201, 3280, 3349], 'Jaitovich': [939, 1405, 1783, 2127, 2219, 2286, 2676, 2770, 2849, 3132, 3202, 3281, 3350], 'Antico': [941, 1407, 1785, 2129, 2221, 2288, 2678, 2772, 2851, 3134, 3204, 3283, 3352], 'Arciuch': [942, 1408, 1786, 2130, 2222, 2289, 2679, 2773, 2852, 3135, 3205, 3284, 3353], 'V.G.': [943, 1409, 1787, 2131, 2223, 2290, 2680, 2774, 2853, 3136, 3206, 3285, 3354], 'Galli': [944, 1410, 1788, 2132, 2224, 2291, 2681, 2775, 2854, 3137, 3207, 3286, 3355], 'Hepatology.': [948, 1414, 1792, 2136, 2228, 2295, 2685, 2779, 2858, 3141, 3211, 3290, 3359], '40:': [950, 1416, 1794, 2138, 2230, 2297, 2687, 2781, 2860, 3143, 3213, 3292, 3361], '157-166Crossref': [951, 1417, 1795, 2139, 2231, 2298, 2688, 2782, 2861, 3144, 3214, 3293, 3362], '(56)': [954, 1420, 1798, 2142, 2234, 2301, 2691, 2785, 2864, 3147, 3217, 3296, 3365], '14Riobo': [957, 2694], 'N.A.': [958, 2695], 'Melani': [959, 2696], 'Sanjuan': [961, 2698], 'N.': [962, 1118, 1152, 1175, 1259, 1282, 1347, 1842, 1878, 2699, 3415, 3988], 'Fiszman': [963, 2700], 'M.L.': [964, 1917, 2701], 'Gravielle': [965, 2702], 'Carreras': [967, 1001, 1113, 1147, 1176, 1254, 1283, 1348, 1740, 2704, 3396, 3416, 3983], '277:': [977, 2714], '42447-42455Abstract': [978, 2715], '(97)': [986, 2723], 'adaptation': [989], 'cold': [991], 'environment': [992], '(15Peralta': [993, 1732, 3388], 'Schopfer': [999, 1119, 1153, 1172, 1260, 1279, 1344, 1738, 3394, 3412, 3989], '2003;': [1008, 1076, 1747, 3403, 4157], '284:': [1009, 1748, 3404], 'H2375-H2383PubMed': [1010, 1749, 3405], 'hypoxia': [1014], '(16Valdez': [1015], 'L.B.': [1016, 3933], 'Zaobornyj': [1017, 3934], 'T.': [1018, 3935], 'Alvarez': [1019], 'Bustamante': [1021], 'Costa': [1023], 'L.E.': [1024], 'Mol.': [1027, 4154, 4178], 'Aspects': [1028], '25:': [1031], '49-59Crossref': [1032], '(50)': [1035], 'Under': [1038], 'physiological': [1039], 'levels': [1041, 3510], 'vivo': [1044, 4033], 'dynamics,': [1046], 'inhibits': [1048], 'state': [1050, 2566, 3379, 3952], '3': [1051, 1625, 1655, 2519, 2567, 3310, 3315, 3380, 3772, 3783, 3804, 3953], '4': [1053, 2008, 2043, 2254, 2263, 2551, 3054, 3078, 3448, 3750], 'uptake': [1055, 1097, 2474, 2553, 3713, 3746, 3889, 3955, 3980, 4053, 4127], '(17Brookes': [1056], 'P.S.': [1057], 'Kraus': [1058], 'D.W.': [1059], 'Shiva': [1060], 'Doeller': [1062], 'J.E.': [1063], 'Barone': [1064], 'Patel': [1066], 'R.P.': [1067], 'Lancaster': [1068], 'Jr.,': [1069], 'Darley-Usmar': [1071], 'V.': [1072], '278:': [1077], '31603-31609Abstract': [1078], '(105)': [1086], '10–20': [1090], 'nm,': [1091], 'tonically': [1094], 'modulates': [1095], 'reversible': [1099], 'inhibition': [1100, 1235, 3335, 3384, 3950, 3977], 'oxidase': [1103, 1238, 2631, 4085], 'through': [1104], 'heme': [1105], 'iron': [1106], 'nitrosylation': [1107], 'at': [1108, 1512, 1664, 1707, 2253, 2262, 2322, 2358, 2397, 2418, 2525, 2606, 2614, 2627, 2642, 2737, 2791, 2810, 2927, 3077, 3171, 3473, 3610, 4071, 4077], 'a-a3': [1109], 'subunit': [1110, 1461, 1467, 2368, 3062, 3067], '(18Poderoso': [1111, 1145, 1252, 3981], 'Lisdero': [1115, 1149, 1170, 1256, 1277, 1342, 3410, 3985], 'Riobo': [1117, 1151, 1174, 1258, 1281, 1346, 3414, 3987], 'Arch.': [1123, 1157, 1264, 3993], 'Biochem.': [1124, 1158, 1265, 1903, 2455, 3028, 3994], 'Biophys.': [1125, 1159, 1266, 2456, 3995, 4194], '1996;': [1126, 1160, 1267, 3996], '328:': [1127, 1161, 1268, 3997], '85-92Crossref': [1128, 1162, 1269, 3998], '(676)': [1131, 1165, 1272, 4001], 'Scholar)': [1133, 1422, 4003], 'promotes': [1135], 'formation': [1137, 1225], '(O2·¯)': [1140, 2900, 3300], 'hydrogen': [1142], 'peroxide': [1143], '(H2O2)': [1144], '19Poderoso': [1168, 1275, 3408], '37709-37716Abstract': [1187, 1294, 1359, 3427], '(172)': [1195, 1302, 1367, 3435], 'complexes': [1199, 2619, 2738, 2792], 'II-III,': [1202, 2795], 'production': [1204, 2732, 3236, 3439, 4210], 'depends': [1208], 'autooxidation': [1210], 'intermediary': [1212], 'ubisemiquinone': [1213], 'during': [1214], 'electron': [1215, 2395, 2604], 'transfer': [1216, 4069], 'ubiquinol': [1219], 'pools': [1220], 'c1,': [1223], 'O2·¯.': [1227], 'This': [1228, 3632], 'reaction': [1229, 2649, 2657], 'considerably': [1231], 'amplified': [1232], 'b-c1': [1241], 'segment': [1242], 'augments': [1244], 'reduction': [1246, 2590, 2626, 2807, 3339], 'side': [1249], 'substrates': [1251, 4214], 'mitochondria,': [1306], 'O2·¯': [1307, 2790], 'either': [1309], 'dismutated': [1310], 'H2O2': [1312, 2729, 3183, 3235, 4135, 4212], 'dismutase': [1316], '(Mn-SOD)': [1317], 'reacts': [1319], 'form': [1323], '(ONOO–).': [1325], 'Considering': [1326], 'that,': [1327], 'variations': [1328], 'differently': [1332], 'proportion': [1335], 'these': [1337, 3565], '(19Poderoso': [1340], 'aim': [1371], 'work': [1374], 'search': [1377], 'its': [1384], 'consequences': [1385], 'uptake,': [1388], 'oxidant': [1390], 'yield,': [1391], 'cell': [1393], 'responses': [1394], 'experimentally': [1424], 'related': [1425], 'status.': [1428], 'Materials—3,3′,5-triiodo-l-thyronine': [1429], '(T3),': [1430], 'NG-methyl': [1431], 'l-arginine': [1432, 2514], '(l-NMMA),': [1433], '(l-NAME),': [1437], 'LR-White': [1439], 'acrylic': [1440], 'resin': [1441], 'were': [1442, 1473, 1485, 1493, 1520, 1533, 1558, 1578, 1591, 1662, 1669, 1759, 1767, 1864, 2024, 2106, 2240, 2306, 2333, 2385, 2388, 2410, 2509, 2797, 2831, 2875, 2901, 2963, 2990, 3038, 3051, 3081, 3151, 3161, 3169, 3471, 3505, 3567, 3583, 3901, 4112, 4168], 'Sigma-Aldrich.': [1444], '2′,7′-dichlorofluorescein': [1445], 'diacetate': [1446, 1452], '(DCFH-DA),': [1447], 'hydroethidine': [1448], '(HE),': [1449], '4-amino-5-methylamino-2′,': [1450], '7′-difluorescein': [1451], '(DAF-FM),': [1453], 'MitoTracker': [1454], 'Red': [1455], '580,': [1456], 'SYBR': [1457, 2019], 'Green,': [1458], '39-kDa': [1460, 2367, 3061], 'Complex': [1463, 1469, 2579, 3059, 3064], 'VIc': [1466, 3066], 'IV': [1470, 3065, 3851], 'monoclonal': [1471, 3674], 'antibodies': [1472, 1492, 1519, 1532, 2972, 3041, 3057, 3676], 'Invitrogen-Molecular': [1475], 'Probes.': [1476], 'Leukemia': [1477], 'virus': [1478], 'reverse': [1479], 'transcriptase': [1480], '(MMLV-RT)': [1481], 'Taq': [1483, 2014], 'polymerase': [1484], 'Promega': [1487], 'Corp.': [1488], '(Madison,': [1489], 'WI).': [1490], 'MAPK': [1491], 'Cell': [1495, 2868, 2886, 2951], 'Signaling': [1496], 'Technology': [1497], '(Beverly,': [1498], 'MA).': [1499], 'Monoclonal': [1500, 1514], 'nitrotyrosine': [1501, 2177], 'antibody': [1502, 2173, 2188, 2384], 'provided': [1504, 1544], 'Prof.': [1506], 'Alvaro': [1507], 'Estévez,': [1508], 'University': [1509, 1588], 'Alabama': [1511], 'Birmingham.': [1513], 'polyclonal': [1517, 3084], 'eNOS': [1518, 1941, 3535], 'BD': [1522], 'Transduction': [1523], 'Laboratories.': [1524], 'Polyclonal': [1525], 'Hsp90,': [1528, 2101], 'Santa': [1535], 'Cruz': [1536], 'Biotechnology': [1537], 'Inc.': [1538], '(Santa': [1539, 3075], 'Cruz,': [1540], 'CA).': [1541], 'Methimazole': [1542], 'Laboratorios': [1546], 'Gador': [1547], '(Buenos': [1548], 'Aires,': [1549], 'Argentina).': [1550], 'Animals': [1551], 'Treatments—Male': [1553], 'Wistar': [1554], 'rats': [1555], '(250–300': [1556], 'g)': [1557], 'housed': [1559], 'temperature-controlled': [1562], 'room': [1563], 'food': [1565], 'water': [1567, 1605, 1636], 'ad': [1568], 'libitum;': [1569], 'National': [1570], 'Institutes': [1571], 'Health': [1573], 'criteria': [1574], 'animal': [1576], 'research': [1577], 'followed': [1579, 2045], 'after': [1580, 1716, 2906, 3696], 'approval': [1581], 'Ethics': [1584], 'Committee': [1585], 'Hospital.': [1589], 'Rats': [1590], 'divided': [1592], 'into': [1593], 'five': [1594], 'groups': [1595, 3665, 3882], '(n': [1596, 3179], '=': [1597, 3180, 3244, 3250], '12/group):': [1598], 'hypothyroid,': [1599], '(0.02%': [1600], 'methimazole': [1601, 1614, 1643], '(w/v)': [1602], 'drinking': [1604, 1635], '28': [1607], 'days);': [1608, 1656], 'hypothyroid+T3,': [1609], '(after': [1610], '25': [1611, 3729], 'days': [1612, 1626, 1641], 'received': [1616], '15': [1617], 'μg': [1618, 3047, 3055], 'T3/kg': [1620], 'weight': [1623, 1653], 'intraperitoneal': [1628], 'injection);': [1629], 'hypothyroid+l-NAME,': [1630], '(0.75': [1631], 'mg/ml': [1632], 'l-NAME': [1633], '21': [1640, 2646], 'treatment);': [1644], 'hyperthyroid,': [1645], '(intraperitoneal': [1646], 'injection': [1647], '60': [1649], 'μgofT3/kg': [1650], 'group.': [1659, 3608], 'Blood': [1660], 'samples': [1661, 3080], 'collected': [1663], 'time': [1666], 'animals': [1668], 'killed': [1670], 'estimation': [1672], 'thyrotropin': [1674, 3490], '(TSH)': [1675], 'radioimmunoassay': [1678], '(20Bianchi': [1679], 'M.S.': [1680], 'Catalano': [1681], 'P.N.': [1682], 'Bonaventura': [1683], 'M.M.': [1684], 'Silveyra': [1685], 'Bettler': [1687], 'Libertun': [1689], 'Lux-Lantos': [1691], 'V.A.': [1692], 'Neuroendocrinology.': [1693], '80:': [1695], '129-142Crossref': [1696], '(17)': [1699], 'Basal': [1702], 'Metabolic': [1703, 3166], 'Rate—BMR': [1704], 'measured': [1706, 2434, 2476, 2586, 2652, 2809], '22': [1708], '°C': [1709, 2041, 2052, 2057, 2062, 2420, 2527, 2929], 'non-recirculating': [1712], 'open': [1713], 'flow': [1714, 2904], '30': [1717, 2416, 2615, 2925, 3069], 'min': [1718, 2417, 2524, 2926], 'equilibration': [1720], 'O2-CO2': [1723], 'analyzer': [1724], 'standard': [1726, 2096], 'temperature': [1727], 'pressure': [1729], 'dry': [1730], 'conditions': [1731], 'Isolation': [1752, 2869], 'Purification': [1754], 'Liver': [1756, 2867, 3100], 'Mitochondria—The': [1757], 'livers': [1758], 'excised': [1760, 2991], 'ice-cold': [1762], 'homogenization': [1763], 'medium,': [1764], 'isolated': [1768, 2876], 'purified': [1770], 'described': [1772, 1866, 2759, 2838, 3121, 3270, 3387], 'Minimal': [1801], 'contamination': [1802], 'found': [1804], '(2–3%)': [1805], 'comparing': [1807], 'activities': [1808, 2830, 4063, 4111], 'lactate': [1810], 'dehydrogenase': [1811], '(cytosolic': [1812], 'marker)': [1813, 2374], 'succinate-cytochrome': [1815], 'reductase': [1817], '(mitochondrial': [1818], 'marker).': [1819], 'RT-PCR—Total': [1820], 'RNA': [1822], 'extracted': [1824], 'TRIzol,': [1826], 'RT-PCR': [1828], 'performed': [1830, 2025, 2314, 2944], '(21Cymeryng': [1831, 1867], 'C.B.': [1832, 1868], 'Lotito': [1833, 1869], 'S.P.': [1834, 1870], 'Colonna': [1835, 1871], 'Finkielstein': [1837, 1873], 'Pomeraniec': [1839, 1875], 'Grión': [1841, 1877], 'Gadda': [1843, 1879], 'Maloberti': [1845, 1881], 'Podestá': [1847, 1883], 'E.J.': [1848, 1884], '143:': [1851, 1887], '1235-1242Crossref': [1852, 1888], '(35)': [1855, 1891], 'Primers': [1858], 'β2-microglobulin': [1860, 2072], 'NOS': [1862, 2190, 3682, 3707, 3908, 3918, 4041], 'isoforms': [1863], '22Alvarez': [1894], 'Depino': [1896], 'A.M.': [1897], 'Podhajcer': [1898], 'O.L.': [1899], 'Pitossi': [1900], 'F.J.': [1901], 'Anal.': [1902, 3027], '2000;': [1904, 2459, 4181], '287:': [1905], '87-94Crossref': [1906], '(16)': [1909], '23Ogilvie': [1912], 'Achilling': [1914], 'K.': [1915, 4190], 'Billingsley': [1916], 'Schmidt': [1918], 'H.': [1919, 2452, 2949, 3023], 'FASEB': [1920], '1995;': [1922], '9:': [1923], '799-806Crossref': [1924], '(95)': [1927], 'Scholar):': [1929], 'D1,': [1932, 3113], 'sense': [1933, 1959, 1992], '(5′-GCGTACCCTGACACCAATCT-3′)': [1934], 'antisense': [1936, 1962, 1995], '(5′-GCTCCAGAGACAAGAAACGG-3′).': [1937], 'Nested': [1938], 'PCR': [1939, 1950, 1968, 1982, 1998, 2022, 2079, 3522], 'isoform': [1942, 1971], '(35': [1943], 'cycles)': [1944], 'done': [1946, 1973, 3170], '0.5': [1948, 1975, 2428, 3766], 'μlof': [1949], 'product': [1951, 1983], '30-μl': [1953], 'final': [1954, 1986], 'volume': [1955, 1987], 'inner': [1957, 1989], 'primers,': [1958, 2007], '(5-ATGTGGCTGTCTGCATGGAT-3′)': [1960], '(5′-TTGCTGCACTTCTTTCCAG-3′).': [1963], 'Quantitative': [1964], 'Real-time': [1965, 1997, 2021], 'PCR—Real-time': [1966], 'nested': [1967], 'μl': [1976, 3070], '1/10': [1979], 'dilution': [1980, 2324], '25-μl': [1985], 'primers:': [1990], '(5′-TTCAACTACATCTGTAACCA-3′)': [1993], '(5′-TGAACTGCACATTGGCTGGA-3′).': [1996], 'reactions': [1999, 2023], 'included': [2000, 2089], '0.4': [2001, 3862], 'mm': [2002, 2009, 2176, 2513, 2520, 2558, 2575, 2597, 2743, 2747, 3001, 3005, 3761, 3773, 3794, 3805], 'dNTPs,': [2003], '1': [2004, 2054, 2064, 2596, 3172, 3225], 'μm': [2005, 2425, 2429, 2593, 2601, 2819, 2918, 2922], 'specific': [2006, 3164], 'MgCl2,': [2010], '2.5': [2011], 'units': [2012], 'DNA': [2015, 2027, 2091], 'polymerase,': [2016], '1:30,000': [2018], 'Green.': [2020], 'Engine': [2028], 'Opticon': [2029], '(MJ': [2030], 'Research,': [2031], 'Inc.)': [2032], 'consisted': [2034], 'initial': [2037], 'denaturing': [2038], 'step': [2039], '(94': [2040], 'min),': [2044], '35': [2047], 'cycles': [2048], '(each': [2049], '94': [2051], 'min,': [2055], '55': [2056], '40': [2059], 's,': [2060], '72': [2061], 'min).': [2065], 'Sample': [2066], 'quantification': [2067], 'normalized': [2069], 'endogenous': [2071], 'quantified': [2076, 3518], 'real-time': [2078, 3521], 'following': [2080], 'same': [2082], 'protocol': [2083], 'isoform.': [2086], 'Each': [2087], 'experiment': [2088], 'minus': [2092], 'curve.': [2097], 'Immunoblotting': [2098, 3103], 'NOS,': [2100], 'Mitochondrial': [2103, 2402, 2467, 2726, 3182, 3299, 3873, 4121], 'Protein': [2104, 3072, 3087], 'Nitration—Proteins': [2105], 'electrophoresed': [2107], '7.5%': [2109], 'SDS-polyacrylamide': [2110], 'gel,': [2111], 'electrotransferred': [2112], 'polyvinylidene': [2114], 'difluoride': [2115], 'membranes': [2116, 2969], 'incubated': [2145, 2411, 2510, 2970, 2993, 3039, 3052], 'anti-nNOS,': [2147], 'anti-eNOS,': [2148], 'anti-iNOS,': [2149], 'anti-Hsp90,': [2150], 'anti-nitrotyrosine': [2152, 2172], 'antibodies,': [2153], 'detected': [2155, 2902, 3162], 'ECL': [2158], 'system.': [2159], 'Equal': [2160], 'loading': [2161, 3088], 'controlled': [2163, 3090], 'appropriated': [2166], 'markers.': [2168], 'Incubation': [2169], '10': [2175, 2424, 2746, 2818], 'prior': [2178], 'membrane': [2181, 2373], 'incubation': [2182, 2349], 'ensure': [2186], 'specificity.': [2189], 'Activity': [2191, 2617], 'Subcellular': [2193, 3869], 'Fractions—NOS': [2194], 'determined': [2197, 2555, 2622, 2636, 2832, 3266, 3332], 'cytosolic': [2201, 3702], 'fractions': [2202, 3582], 'conversion': [2204], '[3H]l-arginine': [2206], '[3H]l-citrulline': [2208], 'Immunoelectron': [2237], 'Microscopy—Purified': [2238], 'suspended': [2241], '4%': [2243], 'paraformaldehyde': [2244], '0.5%': [2246], 'glutaraldehyde,': [2247], 'pH': [2248, 2330, 3007], '7.4,': [2249], '2': [2251, 2995, 3308, 3313], 'h': [2252, 2996], '°C,': [2255, 2264], 'washed': [2256, 2334], 'overnight': [2257], '0.32': [2259], 'm': [2260], 'sucrose': [2261], 'then': [2266], 'dehydrated': [2267], '70%': [2269], 'ethanol': [2270], 'embedded': [2272], 'LR': [2274], 'White': [2275], 'Ultrathin': [2304], 'sections': [2305], 'obtained': [2307], '300-mesh': [2309], 'nickel': [2310], 'grids.': [2311], 'Immunocytochemistry': [2312], 'using': [2315], 'primary': [2317, 2383], 'mouse': [2318], 'anti-C-terminal': [2319], '(1095–1289)': [2321], '1:20': [2326], 'phosphate-buffered': [2328, 2336, 2356, 2413], 'saline,': [2329], '7.4.': [2331], 'Grids': [2332], 'saline': [2337, 2357, 2414], 'counterstained': [2339], '1%': [2341, 3011, 3014], 'uranyl': [2342], 'acetate.': [2343], 'Nonspecific': [2344], 'background': [2345], 'blocked': [2347], '5%': [2351, 2422, 2931], 'normal': [2352, 3692], 'goat': [2353], 'serum': [2354], 'beginning': [2360], 'procedure.': [2363], 'Positive': [2364], 'against': [2366, 2973, 3042, 3058, 3083], '(inner': [2372], 'negative': [2376], 'absence': [2380], 'included.': [2386], 'Specimens': [2387], 'observed': [2389], 'Zeiss': [2392], 'EM-109-T': [2393], 'transmission': [2394], 'microscope': [2396], '80': [2398], 'kV.': [2399], 'Detection': [2400, 2871], 'NO—Mitochondria': [2403], '(1': [2404], 'mg': [2405, 2814, 3173], 'per': [2408, 3177], 'ml)': [2409], '37': [2419, 2526, 2928], 'CO2,': [2423], 'DAF-FM,': [2426], 'MitoTracker,': [2430], 'fluorescence': [2432], 'Ortho-Cytoron': [2437], 'Absolute': [2438], 'Cytometer': [2439], '(Johnson': [2440], 'Johnson)': [2442], '(24López-Figueroa': [2443], 'Caamaño': [2445], 'Morano': [2447], 'M.I.': [2448], 'Ronn': [2449], 'L.C.': [2450], 'Akil': [2451], 'Watson': [2453], 'S.J.': [2454], 'Res.': [2457], 'Commun.': [2458], '272:': [2460], '129-133Crossref': [2461], '(111)': [2464], 'Utilization': [2469], 'Electron': [2471, 4068], 'Transfer': [2472], 'Activity—O2': [2473], 'polarographically': [2477], 'Clark-type': [2480], 'electrode': [2481], 'To': [2504, 2788, 3574, 3894], 'assess': [2505], 'effects,': [2507], '0.3': [2512, 3760, 3793], '(l-Arg)': [2515], 'alone': [2516, 3905], 'plus': [2518, 3907], 'l-NMMA': [2521], '5': [2523, 2917, 2921, 3251], 'State': [2550], '6': [2557], 'malate-glutamate': [2559, 2744], 'substrate': [2561, 3919], 'respiration': [2569, 3931], '0.2': [2574], 'adenosine': [2576], 'diphosphate': [2577], '(ADP).': [2578], '(NADH:': [2582], 'ubiquinone': [2583], 'reductase)': [2584], 'rotenone-sensitive': [2589], '50': [2592], '2,3-dimethoxy-6-methyl-1,4-benzoquinone': [2594], 'KCN': [2598], '200': [2600], 'NADH': [2602], 'donor': [2605], '340': [2607], 'nm': [2608, 2644, 2812], 'Hitachi': [2611], 'U3000': [2612], 'spectrophotometer': [2613], '°C.': [2616], 'II-III': [2620, 2741, 4093], '550': [2628, 2643, 2811], 'nm.': [2629], 'Cytochrome': [2630], '(Complex': [2633], 'IV)': [2634], 'monitoring': [2638], 'oxidation': [2641], '(∈550,': [2645], 'mm–1·cm–1);': [2647], 'pseudo-first': [2655], 'order': [2656], 'constant': [2658], '(k′)': [2659], 'expressed': [2661], 'k′/min·mg': [2663], 'Production': [2727], 'O2·¯—H2O2': [2731], 'monitored': [2735], 'spectrofluorometrically': [2736], '(6': [2742], 'succinate': [2748], 'substrate)': [2750], 'F-2000': [2753], 'spectrofluorometer': [2754], '(Hitachi,': [2755], 'Tokyo,': [2756], 'Japan)': [2757], 'determine': [2789], 'subjected': [2798], 'three': [2800], 'freeze/thaw': [2801], 'cycles,': [2802], 'SOD-sensitive': [2804], '(0.1': [2813], 'protein/ml': [2816], 'SOD': [2820], 'subtract': [2822], 'unspecific': [2823], 'reduction).': [2824], 'catalase,': [2826, 4107], 'peroxidase': [2829, 3264, 4110], '7,000': [2834], 'g': [2835], 'supernatants': [2836], 'Intracellular': [2873, 2896], 'Oxidants—Hepatocytes': [2874], 'two-step': [2878], 'collagenase': [2879], 'perfusion': [2880], '(25Berry': [2881], 'M.N.': [2882], 'Friend': [2883], 'D.S.': [2884], '1969;': [2888], '43:': [2889], '506-520Crossref': [2890], '(3633)': [2893], 'oxidants': [2897], 'cytometry': [2905], 'incubating': [2907], 'hepatocytes': [2908], 'phenol': [2910], 'red-free': [2911], "Dulbecco's": [2912], "Eagle's": [2914], 'medium': [2915], 'DCFH-DA': [2919], 'HE': [2923], 'CO2.': [2932], 'Blue': [2933, 2941, 2967], 'Native': [2934], 'Polyacrylamide': [2935], 'Gel': [2936], 'Electrophoresis—To': [2937], 'separate': [2938], 'complexes,': [2940], 'Native-PAGE': [2942], 'according': [2945, 3189], 'Schägger': [2947], '(26Schägger': [2948], 'Methods': [2950, 3938], '65:': [2954], '231-244Crossref': [2955], 'Gels': [2959], 'first': [2961], 'dimension': [2962], 'stained': [2964], 'Coomassie': [2966], '3-nitrotyrosine.': [2974, 3043], 'For': [2975], 'second-dimension': [2976], 'analysis,': [2977], 'gel': [2978], 'bands,': [2979], 'corresponding': [2980], 'region': [2985], 'derived': [2986], '5-mm-wide': [2988], 'lanes,': [2989], 'cathode': [2998], 'buffer': [2999, 3119], '(50': [3000], 'glycine': [3002], '7.5': [3004], 'imidazole,': [3006], '7)': [3008], 'supplemented': [3009, 3902], 'SDS': [3012], 'β-mercaptoethanol': [3015], 'before': [3016], 'electrophoresis': [3017], '10%-16.5%': [3019], 'Tris/glycine': [3020], 'gels': [3021], '(27Schagger': [3022], 'von': [3024], 'Jagow': [3025], '1991;': [3029], '199:': [3030], '223-231Crossref': [3031], '(1918)': [3034], 'Membranes': [3037], 'Immunoprecipitation—For': [3044], 'immunoprecipitations,': [3045], '500': [3046], 'A/G': [3073], 'PLUS-agarose': [3074], 'Cruz)': [3076], '°C;': [3079], 'blotted': [3082], 'antibody.': [3086], 'respective': [3093], 'antibodies.': [3096, 3165], 'Preparation': [3097], 'Whole': [3099], 'Homogenates': [3101], 'MAPKs': [3105, 3110, 3160], 'Cyclin': [3107], 'D1—To': [3108], 'study': [3109], 'homogenized': [3116], 'lysis': [3118], 'Proteins': [3150], 'separated': [3152], '12%': [3154], 'SDS-PAGE,': [3155], 'Calculations—All': [3167], 'experiments': [3168], 'ml': [3178], '5).': [3181], 'steady-state': [3184, 3301], 'concentration': [3185, 3302], '([H2O2]ss)': [3186], 'calculated': [3188, 3305, 3372, 3442], 'Ref.': [3191], '13Carreras': [3192], 'Scholar': [3219], 'shown': [3221, 3444, 4206], 'Equation': [3223, 3446], '1.[H2O2]ss=+d[H2O2]/dt/k1×[CAT]+k2×[GPX]Eq.': [3224], 'where': [3226], '+': [3227, 3723], 'd[H2': [3228], 'O2]/dt': [3229], 'l-arginine-dependent': [3234], 'Ms–1': [3238], '(Fig.': [3239, 3511, 3532, 3572, 3630, 3655, 3677, 3704], '2A,': [3240], 'upper': [3241], 'panel),': [3242], 'k1': [3243], '4.6': [3245], '×': [3246, 3252, 3322, 3326], '107m–1s–1,': [3247], 'k2': [3249], '107m–1s–1': [3253], '·': [3254], 'CAT': [3255], 'GPX': [3258], 'correspond': [3259], 'catalase': [3261], 'concentrations': [3265], 'spectrophotometrically': [3267, 3333], 'previously': [3269, 3386], '([(O2·¯)]ss)': [3303], 'Equations': [3307], 'follows.1/2d[H2O2]/dt=-d[O2·¯]/dt-d[O2-]/dt=k3[O2·¯][SOD]+k4[O2·¯][NO]Eq.': [3312], '[O2·¯]ss=1/2d[H2O2]/dtk3[SOD]+k4[NO]Eq.': [3314], 'k3': [3316], 'k4': [3318], 'are,': [3319], 'respectively,': [3320], '2.3': [3321], '109': [3323], '1.9': [3325], '1010m–1': [3327], 's–1,': [3328], '[SOD]': [3330], 'Matrix': [3368], '([NO]ss)': [3370], 'percentage': [3375], 'NO-dependent': [3383], '[ONOO–]': [3438], '4.d[ONOO-]/-dt=k4[NO][O2·¯]Eq.': [3447], 'Statistical': [3449], 'Analysis—Data': [3450], 'mean': [3452], '±': [3453, 3726, 3728, 3730, 3737, 3739, 3741, 3743, 3752, 3754, 3756, 3758, 3763, 3765, 3768, 3770, 3775, 3777, 3779, 3781, 3785, 3787, 3789, 3791, 3796, 3798, 3800, 3802, 3807, 3809, 3811, 3813, 3818, 3820, 3822, 3824, 3831, 3833, 3835, 3837, 3843, 3845, 3847, 3849, 3855, 3857, 3859, 3861], 'S.E.': [3454], 'One-way': [3455], 'analysis': [3456, 3468], 'variance': [3458], 'utilized': [3460], 'post': [3462], 'hoc': [3463], 'Dunnett': [3464], 'test,': [3465], 'regression': [3467], 'significance': [3470], 'accepted': [3472], 'p': [3474], '<0.05.': [3475], 'Transcriptional': [3479], 'Increase': [3480], 'Enhances': [3483], 'Content—Thyroid': [3485], 'discriminated': [3488], 'BMR': [3492], 'measurements': [3493], '(Table': [3494, 3892, 4017, 4098], '1).': [3495, 3893, 4018, 4099], 'mRNA,': [3500], 'expression,': [3502], 'clearly': [3506], 'T3': [3509, 3697], '1,': [3512], 'A–E).': [3513], 'Likewise,': [3514, 3948], 'RT': [3520], '>3-fold': [3524], 'compared': [3529], 'controls': [3531], '1B),': [3533], 'whereas': [3534, 4083], 'iNOS': [3537], '(data': [3542], 'shown).': [3544], 'addition,': [3546], 'became': [3548], 'distinctively': [3549], '(mtNOS),': [3553], 'indicating': [3554], 'subsequent': [3556], 'import': [3557], 'overexpressed': [3560], 'enzyme': [3561], 'organelles;': [3564], 'findings': [3566], 'reverted': [3568], 'replacement': [3571], '1C).': [3573, 3631], 'corroborate': [3575], 'groups,': [3580], 'compared.': [3584], 'Western': [3585], 'blotting': [3586], 'confirmed': [3587], 'total': [3591], 'represented': [3594], 'homogenates': [3597], 'enrichment': [3600], 'fraction': [3604], 'Differentially,': [3609], 'had': [3615, 3883], 'results': [3616, 4020, 4167], 'similar': [3617], 'controls,': [3619, 3964], 'condition': [3622], 'retained': [3623], 'cytosol': [3629], 'effect': [3633], 'parallel': [3635], '90': [3644], '(Hsp90),': [3645], 'one': [3646], 'most': [3649], 'chaperones': [3651], '1F).': [3656], 'Alternatively,': [3657], 'modulation': [3658], 'content': [3661], 'studied': [3664], 'validated': [3667], 'well': [3669, 4171], 'immunoelectron': [3671], 'microscopy': [3672], '1D).': [3678], 'agreement,': [3680, 3971], 'Ca2+-dependent': [3681], 'significantly': [3685], 'slightly': [3694], 'opposite': [3701, 3915, 4166], 'pattern': [3703], '1E);': [3705], 'Ca2+-independent': [3706], 'detected.TABLE': [3711], '1Oxygen': [3712], 'rates': [3714], 'depend': [3715], 'utilizationControlHypothyroidHypothyroid': [3722], 'T3HyperthyroidTSH': [3724], '(ng/ml)12': [3725], '2>80*11': [3727], '1*Basal': [3731], '(ml': [3734], 'O2/min·kg0.75)17': [3736], '112': [3738], '1*18': [3740], '123': [3742], '1*Mitochondrial': [3744], '(ngat/min·mg': [3747], 'protein)State': [3749], 'uptakeBasal14.2': [3751], '1.311.5': [3753], '1.715.8': [3755], '1.716.9': [3757], '0.3+': [3759], 'l-Arg13.8': [3762], '0.79.0': [3764], '†14.0': [3767], '1.714.8': [3769], '0.6+': [3771], 'l-NMMA15.6': [3774], '0.812.4': [3776], '2.014.6': [3778], '1.816.2': [3780], '2State': [3782], 'uptakeBasal79': [3784], '649': [3786], '3*†89': [3788], '5102': [3790], '10+': [3792], 'l-Arg72': [3795], '746': [3797], '2†*85': [3799], '5106': [3801], '10*+': [3803], 'l-NMMA86': [3806], '862': [3808], '4*92': [3810], '5105': [3812], '8Calculated': [3814], '(nm)23': [3817], '994': [3819], '754': [3821], '156': [3823], '3Enzyme': [3825], 'activitiesComplex': [3826], '(nmole/min·mg': [3828, 3840], 'protein)108': [3830], '1641': [3832], '15*85': [3834], '998': [3836], '9Complex': [3838], 'II/III': [3839], 'protein)66': [3842], '1962': [3844], '2063': [3846], '1669': [3848], '1Complex': [3850], '(k′/min·mg': [3852], 'protein)13.7': [3854], '0.312.3': [3856], '0.2*13.5': [3858], '0.414.6': [3860], 'Open': [3863], 'table': [3864], 'new': [3867], 'tab': [3868], 'Localization': [3871], 'Modulates': [3872], 'Respiration—According': [3874], 'organelles': [3877], 'hypo-': [3879], 'hyperthyroid': [3881], 'lowest': [3885], 'highest': [3887], 'rates,': [3890], 'respectively': [3891], 'discern': [3895], 'l-Arg': [3904, 3976], 'l-NMMA.': [3910], 'The': [3911], 'sum': [3912], 'determines': [3926], 'functional': [3928], '(28Valdez': [3932], 'Enzymol.': [3939], '396:': [3941], '444-455Crossref': [3942], '(43)': [3945], 'mtNOS-dependent': [3949], '∼39%': [3958], 'samples,': [3961], '18%': [3962], 'negligible': 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