Livin, a Novel Inhibitor of Apoptosis Protein Family Member

Name: Work Video:
Duration: 3 min 30 s
Gary M. Kasof; Bruce Gomes
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919, 1028, 1161, 1529, 1692, 2138, 2240, 2513, 2538, 2570, 2606, 2789, 2840, 2847, 2872, 2912, 2956, 2975, 3032, 3069, 3151, 3218, 3238, 3350, 3359, 3366, 3405, 3449, 3490, 3599, 3610, 3616, 3626, 3677, 3717, 3863, 3908, 3939, 3957, 4137, 4220, 4312], 'the': [44, 47, 100, 108, 136, 140, 150, 157, 174, 189, 203, 211, 216, 219, 321, 324, 377, 385, 413, 417, 427, 434, 451, 466, 480, 488, 493, 496, 599, 627, 689, 819, 825, 842, 849, 852, 906, 910, 923, 928, 1016, 1073, 1086, 1152, 1237, 1262, 1268, 1271, 1282, 1375, 1395, 1486, 1496, 1517, 1614, 1955, 2121, 2182, 2214, 2225, 2246, 2271, 2283, 2317, 2478, 2553, 2565, 2580, 2639, 2658, 2667, 2826, 2888, 2904, 2962, 3001, 3015, 3036, 3044, 3097, 3229, 3310, 3337, 3344, 3509, 3522, 3606, 3629, 3732, 3737, 3763, 3798, 3804, 3829, 3925, 3953, 3958, 3967, 3984, 3996, 4029, 4044, 4061, 4064, 4068, 4127, 4194, 4323, 4338, 4346, 4351, 4494], 'exception': [45, 322, 826], 'placenta,': [48, 325, 4149], 'but': [49, 326, 915, 1274, 1750, 3530, 3885, 4020, 4504], 'present': [51, 328, 1753, 3704], 'developmental': [53, 330, 3915], 'several': [57, 334, 702, 3920, 4315], 'cancer': [58, 275, 335, 552, 1703, 1958, 2746, 3921, 4039, 4125, 4153], 'cell': [59, 68, 244, 336, 345, 521, 853, 1704, 1748, 2197, 2593, 2649, 2747, 2905, 3922, 4040, 4046, 4079, 4154], 'lines.': [60, 337, 3923], 'Highest': [61, 338], 'levels': [62, 339, 1633, 1878, 4022, 4033, 4147], 'were': [63, 200, 340, 477, 2310, 2331, 2437, 2480, 2536, 2557, 2598, 2619, 2627, 2755, 2786, 2838, 2910, 2954, 2972, 3024, 3109, 3149, 3172, 3183, 3205, 3236, 3289, 3307, 3334, 3341, 3352, 3372, 3417, 3432, 3466, 3483, 3501, 3517, 3536, 3551, 3559, 3590, 3608, 3624, 3667, 3937, 3970, 3980, 4036], 'observed': [64, 341], 'two': [66, 343], 'melanoma-derived': [67, 344], 'lines,': [69, 346, 1749, 4041], 'G361': [70, 347, 4048], 'SK-Mel29.': [72, 349], 'Transfection': [73, 350], 'HeLa': [77, 354, 3355, 3534, 3596, 4057], 'cells': [78, 355, 1959, 2618, 2837, 2953, 2971, 2997, 3029, 3356, 3535, 3597, 3607], 'resulted': [79, 356], 'protection': [81, 358, 1202], 'from': [82, 359, 696, 927, 1203, 2335, 2365, 2378, 2383, 2400, 2646, 2740, 2833, 3026, 3595, 3911, 3972], 'induced': [84, 178, 361, 455, 1858], 'expression': [86, 363, 1952, 2189, 3601, 4131, 4140], 'FADD,': [88, 365, 2327, 4328], 'Bax,': [89, 366, 2328], 'RIP,': [90, 367, 4329], 'RIP3,': [91, 368, 4330], 'DR6.': [93, 370], 'Similar': [94, 371], 'to': [95, 215, 270, 372, 492, 547, 698, 832, 901, 903, 1031, 1072, 1138, 1187, 1278, 1441, 1503, 1626, 1954, 2088, 2091, 2116, 2164, 2177, 2551, 2559, 2638, 2666, 2757, 2886, 2939, 2961, 3043, 3321, 3456, 3508, 3519, 3546, 3712, 3743, 3783, 3797, 3822, 3839, 3842, 3845, 3848, 3852, 3861, 3865, 4025, 4052, 4067, 4314], 'other': [96, 373, 1490, 1685, 2078, 2169, 3823, 3973, 4018], 'members,': [99, 376, 712, 823, 2171, 3976], 'anti-apoptotic': [101, 378, 1141, 1157, 1283, 1397, 2079, 4200, 4223, 4306], 'activity': [102, 119, 379, 396, 1158, 1284, 1398, 1438, 1449, 3011, 4307], 'dependent': [106, 148, 383, 425, 1451], 'on': [107, 149, 384, 426, 1267, 1452, 1524, 2869, 2987, 3813, 3828], 'BIR': [109, 151, 386, 428, 1144, 1190, 1194, 2141, 3719, 3870, 4195, 4206, 4294], 'also': [113, 390, 1070, 1250, 1429], 'capable': [114, 391, 2174], 'inhibiting': [116, 393], 'DEVD-like': [117, 259, 394, 536], 'caspase': [118, 260, 395, 537, 926, 1020, 1128, 1199, 3045, 4203], 'triggered': [120, 397, 607], 'tumor': [122, 399, 561, 628], 'necrosis': [123, 400, 562, 629], 'factor-α.': [124, 401], 'In': [125, 155, 213, 402, 432, 490, 1630, 2730, 3083, 3201], 'vitro': [126, 403, 3084, 3202], 'binding': [127, 404, 2176, 3203], 'studies': [128, 229, 405, 506, 1427], 'demonstrated': [129, 406], 'direct': [131, 408, 4509], 'interaction': [132, 409, 1160, 1200], 'between': [133, 410, 1600, 4132], 'active': [137, 414, 890, 907, 3210, 3329], 'form': [138, 415, 1075], 'downstream': [141, 418, 1089, 1132], 'caspases,': [142, 419, 839], 'caspase-3': [143, 420, 3017, 3211, 3243], '-7,': [145, 422, 914, 3331], 'that': [146, 231, 423, 508, 1150, 1431, 1447, 1608, 1620, 1950, 2134, 3521, 3978, 4012], 'Livin.': [154, 431, 2205], 'addition,': [156, 433, 1631, 2731], 'unprocessed': [158, 435], 'cleaved': [160, 437], 'forms': [161, 438, 876, 908, 1146], 'caspase-9': [163, 177, 440, 454, 1077, 3087, 3092, 3351, 3495], 'co-immunoprecipitated': [164, 441], 'vivo,': [168, 445], 'recombinant': [170, 447, 3209], 'could': [172, 239, 449, 516, 2180, 3526], 'inhibit': [173, 450, 905, 2181], 'activation': [175, 452], 'Apaf-1,': [180, 457], 'cytochrome': [181, 458], 'c,': [182, 459], 'dATP.': [184, 461], 'subcellular': [186, 225, 463, 502, 3584], 'distribution': [187, 464, 3900, 4122], 'transfected': [190, 467, 2952, 3028, 3358, 3598], 'analyzed': [193, 470], 'immunofluorescence.': [195, 472], 'Both': [196, 473], 'Survivin': [199, 476, 718, 897, 1738, 1856, 1940, 1951, 3220, 3568, 3589, 3862], 'expressed': [201, 478, 4015], 'nucleus': [204, 481], 'filamentous': [208, 485], 'pattern': [209, 486], 'throughout': [210, 487], 'cytoplasm.': [212, 489], 'contrast': [214, 491], 'apoptotic': [217, 494, 632, 879, 1272, 4324, 4352], 'activity,': [218, 495, 1129], 'mediated': [223, 500], 'its': [224, 501, 1080, 1525, 1876, 2168], 'localization': [226, 503], 'patterning.': [227, 504], 'Further': [228, 505], 'found': [230, 507, 1430, 1700, 3755, 3802, 3892, 4002], 'transfection': [232, 509], 'an': [234, 252, 511, 529, 1391, 2159, 2230, 2488, 2913, 2919, 3672, 3701, 3745, 3758, 4199, 4302], 'antisense': [235, 512, 1942, 2160, 2274, 2937, 3523], 'construct': [236, 513, 2161, 2227, 3524], 'against': [237, 514, 3241, 3439, 3453, 3494, 3566, 3628], 'trigger': [240, 517], 'specifically': [242, 519], 'lines': [245, 522, 1705, 2198, 2594, 2650, 2748, 4047, 4080, 4155], 'expressinglivin': [246, 523], 'mRNA.': [247, 524], 'This': [248, 525, 3772], 'associated': [250, 527], 'increase': [253, 530], 'DNA': [255, 532, 2491], 'fragmentation': [256, 533], 'activity.': [261, 538], 'Thus,': [262, 539], 'disruption': [263, 540], 'may': [266, 543, 1022, 1610, 1874, 4297, 4505], 'provide': [267, 544], 'strategy': [269, 546], 'induce': [271, 548, 2165, 2940], 'certain': [274, 551, 845], 'cells.': [276, 553, 2892], 'factor-α': [563, 630], 'polymerase': [564], 'chain': [565], 'reaction': [566], '4-morpholinepropanesulfonic': [567], 'acid': [568, 596, 3190, 3787], 'green': [569, 2827], 'fluorescent': [570, 2483, 2828, 3018, 3037], '7-amino-4-trifluoromethylcoumarin': [572], 'polyacrylamide': [573], 'gel': [574, 2703], 'electrophoresis': [575], '(IAPs)1': [581], 'is': [583, 922, 1151, 1196, 1450, 1477, 1481, 1739, 1751, 1857, 4010, 4014, 4334, 4344, 4498], 'characterized': [584, 1536], 'one': [586], 'or': [587, 838, 1943, 2768, 3212, 3221, 3244, 3362, 3448, 3631], 'more': [588, 1024], 'repeats': [589], 'highly': [592], 'conserved': [593, 694], '∼70': [594], 'amino': [595], 'suppress': [605], 'wide': [610], 'variety': [611], 'stimuli,': [613, 2157], 'including': [614, 4326], 'viral': [615, 1246], 'infection,': [616], 'chemotherapeutic': [617], 'drugs,': [618], 'staurosporin,': [619], 'growth': [620, 1866, 1869], 'factor': [621], 'withdrawal,': [622], 'components': [625], '(TNF-α)/Fas': [631], 'signaling': [633], 'pathways': [634], '(1Deveraux': [635], 'Q.L.': [636, 932, 951, 1098, 1291], 'Reed': [637, 937, 956, 980, 1114, 1217, 1296, 1320, 1728, 1786, 4184, 4237], 'J.C.': [638, 938, 957, 981, 1115, 1218, 1297, 1321, 1729, 1787, 2405, 2443, 4185, 4238], 'Genes': [639, 4106], 'Dev.': [640], '1999;': [641, 671, 1174, 1805, 1851, 1930, 1970, 2020, 4444, 4477], '13:': [642], '239-252Crossref': [643], 'PubMed': [644, 661, 679, 730, 759, 790, 812, 864, 943, 963, 1011, 1061, 1121, 1177, 1230, 1303, 1333, 1351, 1368, 1421, 1470, 1593, 1678, 1769, 1908, 1933, 1994, 2023, 2046, 2417, 2455, 4112, 4167, 4250, 4267, 4286, 4399, 4422, 4452, 4485], 'Scopus': [645, 662, 680, 731, 760, 791, 813, 865, 944, 964, 1062, 1122, 1178, 1231, 1304, 1334, 1352, 1369, 1422, 1471, 1594, 1679, 1770, 1909, 1934, 1995, 2024, 2047, 2418, 2456, 4113, 4168, 4251, 4268, 4287, 4379, 4400, 4423, 4453, 4486], '(2270)': [646], 'Google': [647, 664, 682, 733, 762, 793, 815, 867, 946, 966, 987, 1012, 1064, 1124, 1180, 1233, 1306, 1336, 1354, 1371, 1424, 1473, 1596, 1681, 1736, 1772, 1793, 1808, 1827, 1840, 1854, 1911, 1936, 1973, 1997, 2026, 2049, 2070, 2111, 2420, 2458, 4115, 4170, 4191, 4253, 4270, 4289, 4381, 4402, 4425, 4455, 4488], 'Scholar,': [648, 665, 734, 763, 794, 947, 967, 988, 1307, 1337, 1355, 1773, 1794, 1809, 1828, 1841, 1974, 1998, 2027, 2050, 4171, 4254, 4271, 4456], '2LaCasse': [649], 'E.C.': [650], 'Baird': [651, 772, 1555], 'S.': [652, 773, 992, 1416, 1459, 1556, 1713, 1717, 2010, 2037, 4279, 4361], 'Korneluk': [653, 784, 1582, 1667, 1922], 'R.G.': [654, 785, 1583, 1668, 1888, 1923], 'MacKenzie': [655, 782, 1584, 1669], 'A.E.': [656], 'Oncogene.': [657, 1057], '1998;': [658, 861, 984, 1118, 1222, 1325, 1365, 1790, 1824, 1837, 1986, 2043, 2108, 4188, 4242, 4264, 4283, 4376], '17:': [659, 1119], '3247-3259Crossref': [660], '(940)': [663], '3Miller': [666], 'L.K.': [667, 1361, 4260], 'Trends': [668], 'Cell': [669, 2018, 3370, 3549, 4281], 'Biol.': [670, 1173, 1220, 1323, 1364, 1898, 1984, 2019, 4240, 4263, 4282, 4442, 4476], '9:': [672, 4478], '323-328Abstract': [673], 'Full': [674, 676, 809, 1225, 1227, 1328, 1330, 1348, 1590, 1903, 1905, 1989, 1991, 4245, 4247, 4396, 4419, 4447, 4449, 4480, 4482], 'Text': [675, 677, 810, 1226, 1228, 1329, 1331, 1349, 1591, 1904, 1906, 1990, 1992, 4246, 4248, 4397, 4420, 4448, 4450, 4481, 4483], 'PDF': [678, 811, 1229, 1332, 1350, 1592, 1907, 1993, 4249, 4398, 4421, 4451, 4484], '(316)': [681], 'Scholar).': [683, 816, 868, 1013, 1065, 1125, 1181, 1234, 1372, 1425, 1474, 1597, 1682, 1737, 1855, 1937, 2071, 2112, 2459, 4116, 4192, 4290, 4382], 'While': [684, 1182, 4117, 4193], 'first': [685], 'identified': [686, 1522, 2130, 2212], 'baculovirus,': [688], 'has': [692, 1380, 4119], 'been': [693, 830, 899, 1501, 1690], 'evolutionarily': [695], 'viruses': [697], 'nematodes,': [699], 'flies,': [700], 'mammalian': [703], 'species.': [704], 'There': [705], 'are': [706, 871, 881, 1634, 1699, 4135, 4208, 4217, 4490], 'currently': [707], 'five': [708], 'c-IAP1,': [713, 893, 1066, 3840, 3894], 'c-IAP2,': [714, 894, 1067, 1241, 3843, 3895], 'XIAP,': [715, 895, 1242, 3846], 'NAIP,': [716, 828, 1601, 3849], '(4Ambrosini': [719, 1758, 4156], 'G.': [720, 775, 1550, 1721, 1759, 1976, 1980, 2031, 4157, 4277, 4355, 4365], 'Adida': [721, 1760, 1977, 4158], 'C.': [722, 771, 1560, 1761, 1917, 1978, 4159, 4367], 'Altieri': [723, 1762, 1801, 1812, 1831, 1893, 1966, 1981, 2015, 2040, 2096, 4160], 'D.': [724, 1004, 1357, 1763, 1796, 1884, 1961, 2060, 2407, 2445, 4103, 4161, 4256], 'Nat.': [725, 1171, 1764, 2017, 4162], 'Med.': [726, 1674, 1765, 4163], '1997;': [727, 940, 960, 1300, 1418, 1675, 1766, 4109, 4164], '3:': [728, 1676, 1767, 4165], '917-921Crossref': [729, 1768, 4166], '(3000)': [732, 1771, 4169], '5Duckett': [735], 'C.S.': [736, 1666], 'Nava': [737], 'V.E.': [738], 'Gedrich': [739], 'R.W.': [740], 'Clem': [741], 'R.J.': [742], 'van': [743, 1103], 'Dongen': [744], 'J.L.': [745], 'Gilfillan': [746], 'M.C.': [747], 'Shiels': [748], 'H.': [749, 1042, 1566, 1711, 1811, 2095], 'Hardwick': [750], 'J.M.': [751, 1798, 1963, 4101], 'Thompson': [752, 1665, 4086], 'C.B.': [753], 'EMBO': [754, 958, 1116, 1298], 'J.': [755, 781, 959, 994, 1117, 1219, 1299, 1322, 1849, 1897, 1913, 1915, 1983, 2008, 2035, 4239, 4280, 4371, 4432, 4441, 4464], '1996;': [756, 787], '15:': [757, 1852], '2685-2689Crossref': [758], '(519)': [761], '6Liston': [764], 'P.': [765, 1572, 1664, 2054, 4408], 'Roy': [766, 1099], 'N.': [767, 949, 977, 1100, 1214, 1289, 1317, 1544, 1783, 1821, 1834, 2105, 4181, 4234], 'Tamai': [768, 1567, 1657], 'K.': [769, 1000, 1050, 1056, 1212, 1315, 1568, 1658, 1715, 1886, 4232, 4387], 'Lefebvre': [770, 1559], 'Cherton-Horvat': [774], 'Farahani': [776, 1553], 'R.': [777, 934, 953, 1206, 1293, 1309, 1554, 4089, 4097, 4226], 'McLean': [778, 1547], 'M.': [779, 796, 998, 1002, 1044, 1054, 1548, 1564, 1656, 1727, 1817, 1847, 2101, 4275, 4389, 4462], 'Ikeda': [780, 1580, 1661], 'A.': [783, 1038, 1417, 1558, 1585, 1670, 1725, 1882, 2012], 'Nature.': [786, 939, 2042], '379:': [788], '349-353Crossref': [789], '(867)': [792], '7Rothe': [795], 'Pan': [797], 'M.-G.': [798], 'Henzel': [799], 'W.J.': [800, 1359, 4258], 'Ayres': [801], 'T.M.': [802], 'Goeddel': [803], 'D.V.': [804], 'Cell.': [805, 1344, 1363, 1586, 4262, 4392, 4415], '1995;': [806, 1345, 1587, 4393, 4416], '83:': [807, 1346], '1243-1252Abstract': [808], '(1053)': [814], 'All': [817, 3287], 'have': [829, 898, 1139, 1428, 1435, 1500, 1689, 2082, 3879, 4507], 'shown': [831, 2163, 3353], 'interact': [833, 918], 'specific': [835, 2202, 3981], 'cysteine': [836], 'proteases,': [837, 1090], 'required': [840, 1280, 1612, 2901], 'cleavage': [843, 3046], 'proteins': [846, 1239, 3108, 4219, 4296, 4492], 'involved': [847], 'disassembly': [850], 'during': [854, 1444, 2193], '(8Thornberry': [856], 'N.A.': [857], 'Lazebnik': [858], 'Y.': [859, 971, 1046, 1048, 1457, 1777, 1843, 1845, 4175, 4474], 'Science.': [860, 1466], '281:': [862], '1312-1316Crossref': [863], '(6137)': [866], 'caspases': [870, 1162, 2178], 'synthesized': [872], 'as': [873, 1083, 1085, 1092, 1243, 1245, 1863, 2075, 2077, 2898, 3005, 3561, 3917, 3919, 3931, 4210, 4301], 'inactive': [874], 'zymogen': [875, 1074], 'which': [877, 921, 1439, 1873, 2131, 3416, 3756, 3774], 'upon': [878], 'stimulation': [880], 'proteolytically': [882], 'processed': [883], 'sequential': [886], 'manner': [887], 'into': [888, 2264, 2282, 2316, 2344, 2371, 2376, 2424, 3113], 'their': [889, 1156, 1256, 1442, 1453, 2089], 'heterotetrameric': [891], 'forms.': [892], 'reported': [900, 1502], 'bind': [902, 1071], 'terminal': [911], 'caspases-3': [912], 'do': [916], 'caspases-8,': [920], 'proximal': [925], 'TNF-α/Fas': [929, 4495], 'receptor': [930, 4340], '(9Deveraux': [931], 'Takahashi': [933, 952, 1292], 'Salvesen': [935, 954, 1112, 1215, 1294, 1318, 4235], 'G.S.': [936, 955, 1113, 1216, 1295, 1319, 1672, 4236], '388:': [941], '300-304Crossref': [942], '(1712)': [945], '10Roy': [948], 'Deveraux': [950, 1207, 1290, 1310, 4227], '16:': [961, 1301], '6914-6925Crossref': [962, 1302], '(1131)': [965, 1305], '11Tamm': [968, 1774, 4172], 'I.': [969, 996, 1210, 1313, 1707, 1775, 4173, 4230], 'Wang': [970, 1776, 4174, 4360], 'Sausville': [972, 1778, 4176], 'E.': [973, 1779, 1921, 4177, 4412, 4466], 'Scudiero': [974, 1718, 1780, 4178], 'D.A.': [975, 1341, 1719, 1781, 4179], 'Vigna': [976, 1782, 4180], 'Oltersdorf': [978, 1784, 4182], 'T.': [979, 1040, 1052, 1105, 1785, 1819, 2103, 4183, 4434], 'Cancer': [982, 1731, 1788, 1822, 1835, 2065, 2106, 4186], 'Res.': [983, 1732, 1789, 1823, 1836, 1928, 2066, 2107, 4187], '58:': [985, 1791, 1825, 1838, 2109, 4189], '5315-5320PubMed': [986, 1792, 4190], '12Conway': [989], 'E.M.': [990], 'Pollefeyt': [991], 'Cornelissen': [993], 'DeBaere': [995], 'Steiner-Mosonyi': [997], 'Ong': [999], 'Baens': [1001], 'Collen': [1003], 'Schuh': [1005], 'A.C.': [1006], 'Blood.': [1007], '2000;': [1008, 1058, 1467, 1733, 1900, 2067, 2414, 2452], '95:': [1009], '1435-1442Crossref': [1010], 'However,': [1014, 1475, 3875], 'case': [1017], 'Survivin,': [1019, 2074, 3884], 'inhibition': [1021, 1032], 'be': [1023, 1279, 1611, 1642, 4026, 4298], 'indirect': [1025, 3593], 'through': [1026, 1541, 3336], 'association': [1027], 'Cdk4': [1029], 'leading': [1030], 'pro-caspase-3': [1034], 'p21': [1036], '(13Suzuki': [1037], 'Ito': [1039], 'Kawano': [1041], 'Hayashida': [1043], 'Hayasaki': [1045], 'Tsutomi': [1047], 'Akahane': [1049], 'Nakano': [1051], 'Miura': [1053], 'Shiraki': [1055], '19:': [1059, 4110], '1346-1353Crossref': [1060], '(274)': [1063], 'XIAP': [1069, 1434, 1696], 'thereby': [1078, 1389, 2578], 'preventing': [1079], 'proteolytic': [1081, 2183], 'processing': [1082, 1087, 2184, 3085], 'well': [1084, 1244, 2076, 3918], 'such': [1091, 1862], 'caspase-3,': [1093], '-6,': [1094], '-7': [1096, 3213, 3245], '(14Deveraux': [1097], 'Stennicke': [1101], 'H.R.': [1102], 'Arsdale': [1104], 'Zhou': [1106], 'Q.': [1107, 1208, 1311, 4228], 'Srinivasula': [1108], 'S.M.': [1109, 1709], 'Alnemri': [1110], 'E.S.': [1111], '2215-2223Crossref': [1120], '(1237)': [1123], 'Abrogation': [1126], 'common': [1131], 'component': [1133], 'apoptosis,': [1135, 4214], 'enables': [1136], 'IAPs': [1137, 1184, 1287, 1396], 'widespread': [1140], 'potential.': [1142], 'zinc-fold': [1149], 'critical': [1153, 1383], 'motif': [1154, 4196], '(15Hinds': [1163], 'M.G.': [1164], 'Norton': [1165], 'R.S.': [1166, 1925], 'Vaux': [1167], 'D.L.': [1168], 'Day': [1169], 'C.L.': [1170], 'Struct.': [1172], '6:': [1175, 1734], '648-651Crossref': [1176], '(150)': [1179], 'many': [1183], 'contain': [1185, 1251], 'up': [1186], 'three': [1188, 3292, 3468, 3934, 3968], 'tandem': [1189], 'repeats,': [1191], 'sufficient': [1197], '(16Takahashi': [1205, 4225], 'Tamm': [1209, 1312, 4229], 'Welsh': [1211, 1314, 1714, 4231], 'Assa-Munt': [1213, 1316, 4233], 'Chem.': [1221, 1324, 1899, 1985, 4241, 4443], '273:': [1223, 1326, 1987, 4243], '7787-7790Abstract': [1224, 1327, 4244], '(521)': [1232, 1335, 4252], 'Many': [1235], '(c-IAP1,': [1240], 'insect': [1248], 'IAPs)': [1249], 'near': [1255], 'COOH': [1257], 'termini.': [1258], 'role': [1260, 1384, 1506, 2203, 4510], 'varies': [1265], 'depending': [1266], 'and/or': [1270], 'stimulus,': [1273], 'does': [1275], 'appear': [1277], '(10Roy': [1288], '16Takahashi': [1308], '17Hay': [1338], 'B.A.': [1339], 'Wassarman': [1340], 'Rubin': [1342], 'G.M.': [1343, 2403, 2441], '1253-1262Abstract': [1347], '(642)': [1353], '18Vucic': [1356, 4255], 'Kaiser': [1358, 4257], 'Miller': [1360, 4259], 'Mol.': [1362, 4261], '18:': [1366, 4265], '3300-3309Crossref': [1367, 4266], '(188)': [1370, 4269], 'Deletion': [1373, 2302], 'c-IAP2': [1379], 'suggested': [1381], 'TNF-α-mediated': [1386], 'NF-κB': [1387], 'activation,': [1388], 'providing': [1390], 'additional': [1392], 'mechanism': [1393], '(19Chu': [1399], 'Z.L.': [1400], 'McKinsey': [1401], 'T.A.': [1402, 4438], 'Liu': [1403, 2406, 2444, 4362], 'L.': [1404, 1579], 'Gentry': [1405], 'J.J.': [1406], 'Malim': [1407], 'M.H.': [1408], 'Ballard': [1409], 'D.W.': [1410], 'Proc.': [1411], 'Natl.': [1412], 'Acad.': [1413], 'Sci.': [1414], 'U.': [1415, 2064], '94:': [1419], '10057-10062Crossref': [1420], '(821)': [1423], 'Recent': [1426], 'c-IAP1': [1432, 1698], 'ubiquitin': [1436], 'ligase': [1437], 'leads': [1440], 'degradation': [1443], 'this': [1448, 1480], '(20Yang': [1456], 'Fang': [1458], 'Jensen': [1460], 'J.P.': [1461], 'Weissman': [1462], 'A.M.': [1463, 1660, 4385], 'Ashwell': [1464], 'J.D.': [1465], '288:': [1468], '874-877Crossref': [1469], '(861)': [1472, 4424], 'it': [1476, 3767, 3858], 'unclear': [1478], 'if': [1479], 'general': [1483, 4128], 'feature': [1484], 'members.': [1493], 'Several': [1494], 'members': [1499, 1688, 2119, 3826], 'play': [1504], 'pathological': [1508], 'conditions,': [1509], 'particularly': [1510, 4042], 'neurodegenerative': [1511, 1534], 'disorders': [1512], 'cancer.': [1514, 1693], 'For': [1515, 1694], 'instance,': [1516], 'NAIP': [1518, 1609, 1632, 1647], 'gene': [1519, 2128], 'originally': [1521], 'based': [1523, 3827], 'deletion': [1526, 3225], 'patients': [1528], 'spinal': [1530, 1602, 1627], 'muscular': [1531, 1603, 1628], 'atrophy,': [1532, 1604], 'disorder': [1535], 'motor': [1538], 'neuron': [1539], 'depletion': [1540], '(21Roy': [1543], 'Mahadevan': [1545], 'M.S.': [1546], 'Shutler': [1549], 'Yarghi': [1551], 'Z.': [1552], 'Besner-Johnston': [1557], 'Kang': [1561], 'X.': [1562, 1570, 4430, 4468], 'Salih': [1563], 'Aubry': [1565], 'Guan': [1569, 4098], 'Ioannou': [1571], 'Crawford': [1573], 'T.O.': [1574], 'de': [1575], 'Jong': [1576], 'P.J.': [1577], 'Surh': [1578], 'J.-E.': [1581, 1662], '80:': [1588], '167-178Abstract': [1589], '(871)': [1595], 'correlation': [1599], 'suggests': [1607, 2199], 'survival': [1615, 1956], 'these': [1617, 4133], 'neurons': [1618], 'mutations': [1621], 'theNAIP': [1623], 'locus': [1624, 4070], 'contribute': [1625], 'atrophy.': [1629], 'transiently': [1635, 3027, 3357], 'elevated': [1636, 1877, 4146], 'following': [1637], 'ischemia': [1638], 'damage': [1640], 'can': [1641, 4197], 'inhibited': [1643, 2151], 'overexpression': [1645], 'vivo(22Xu': [1649], 'D.G.': [1650, 4472], 'Crocker': [1651], 'S.J.': [1652], 'Doucet': [1653], 'J.-P.': [1654], 'St-Jean': [1655], 'Hakim': [1659], 'Liston': [1663], 'Robertson': [1671], 'Nature': [1673], '997-1004Crossref': [1677], '(220)': [1680], 'Expression': [1683, 2148], 'correlated': [1691], 'example,': [1695], '(23Tamm': [1706], 'Kornblau': [1708], 'Segall': [1710], 'Krajewski': [1712], 'Kitada': [1716], 'Tudor': [1720], 'Qui': [1722], 'Y.H.': [1723], 'Monks': [1724], 'Andreeff': [1726], 'Clinical': [1730], '1796-1803PubMed': [1735], 'overexpressed': [1740], 'nearly': [1742, 4076], 'all': [1743, 2476, 4077, 4293], 'tumors': [1745, 1880, 4083], 'transformed': [1747, 2196], 'rarely': [1752], '24Grossman': [1795], 'McNiff': [1797, 1962], 'Li': [1799, 1891, 1964], 'F.': [1800, 1892, 1965, 2000, 2029], 'D.C.': [1802, 1813, 1832, 1894, 1967, 1982, 2016, 2041, 2097], 'Lab.': [1803, 1968], 'Invest.': [1804, 1969], '79:': [1806, 1971], '1121-1126PubMed': [1807, 1972], '25Kawasaki': [1810], 'Lu': [1814, 2098], 'C.-D.': [1815, 2099], 'Toyoda': [1816, 2100], 'Tenjo': [1818, 2102], 'Tanigawa': [1820, 1833, 2104], '5071-5074PubMed': [1826, 2110], '26Lu': [1829], 'C.D.': [1830], '1808-1812PubMed': [1839], '27Saitoh': [1842], 'Yaginuma': [1844], 'Ishikawa': [1846], 'Int.': [1848], 'Oncol.': [1850], '137-141PubMed': [1853], 'angiogenic': [1860], 'factors': [1861], 'vascular': [1864], 'endothelial': [1865], 'factor,': [1867, 1870], 'fibroblast': [1868], 'angiopoietin-1': [1872], 'explain': [1875], '(28Papapetropoulos': [1881], 'Fulton': [1883], 'Mahboubi': [1885], 'Kalb': [1887], "O'Connor": [1889], 'D.S.': [1890], 'Sessa': [1895], 'W.C.': [1896], '275:': [1901], '9102-9105Abstract': [1902], '(548)': [1910], 'Scholar,29Tran': [1912], 'Rak': [1914], 'Sheehan': [1916], 'Saibil': [1918], 'S.D.': [1919], 'LaCasse': [1920], 'Kerbel': [1924], 'Biochem.': [1926], 'Biophys.': [1927], 'Commun.': [1929], '264:': [1931], '781-788Crossref': [1932], '(308)': [1935], 'Depletion': [1938], 'using': [1941, 2245, 2487, 2629, 2657, 2815, 2825, 2918, 2944, 3000, 3014, 3060, 3090, 3096, 3134, 3198, 3228, 3302, 3309, 3343, 3354, 3434, 3564, 3648, 3671, 3698], 'dominant': [1944], 'negative': [1945], 'mutants': [1946, 2303], 'induces': [1947], 'implying': [1949], 'contributes': [1953], '(24Grossman': [1960], '30Ambrosini': [1975], 'Sirugo': [1979], '11177-11182Abstract': [1988], '(432)': [1996], '31Li': [1999], 'Ackermann': [2001], 'E.J.': [2002], 'Bennett': [2003], 'C.F.': [2004], 'Rothermel': [2005], 'A.L.': [2006], 'Plescia': [2007, 2034], 'Tognin': [2009, 2036], 'Villa': [2011], 'Marchisio': [2013, 2038], 'P.C.': [2014, 2039], '1:': [2021], '461-466Crossref': [2022], '(553)': [2025], '32Li': [2028], 'Ambrosini': [2030], 'Chu': [2032], 'E.Y.': [2033], '396:': [2044], '580-584Crossref': [2045], '(1723)': [2048], '33Olie': [2051], 'R.A.': [2052, 2062], 'Simões-Wüst': [2053], 'Baumann': [2055], 'B.': [2056, 4414], 'Leech': [2057], 'S.H.': [2058], 'Fabbro': [2059], 'Stahel': [2061], 'Zangemeister-Wittke': [2063], '60:': [2068], '2805-2809PubMed': [2069], 'Tumors': [2072], 'expressing': [2073], 'signal': [2080, 4201], 'generally': [2081], 'poorer': [2084], 'prognosis,': [2085], 'likely': [2086, 4011], 'due': [2087], 'resistance': [2090], 'classical': [2092], 'chemotherapy': [2093], '(25Kawasaki': [2094], 'Here,': [2113], 'we': [2114, 2132, 2228, 2732, 3735, 3775], 'attempted': [2115], 'identify': [2117], 'via': [2124, 4202], 'homology': [2125, 3690], 'searches.': [2126], 'One': [2127], 'termedlivin': [2133], 'encodes': [2135], 'number': [2155, 2221, 3728, 3809, 4074], 'whereas': [2158], 'apoptosis.': [2166, 3548], 'Like': [2167], 'caspase-9in': [2186], 'vitro.': [2187], 'Restricted': [2188], 'development': [2194], 'very': [2201], 'partial': [2207], 'cDNA': [2208, 2233, 2387, 2762, 3739, 3748, 3800, 3927, 3959, 3993], 'sequence': [2209, 2258, 3703, 3795, 3832, 3928], 'oflivin': [2210, 3525], 'proprietary': [2215, 3694], 'Incyte': [2216, 2336, 2366, 3695], 'LifeSeq': [2217], 'data': [2218, 3696, 3806], 'base': [2219, 3697, 3779, 3807], '(accession': [2220, 3727, 3808], '1419118).': [2222, 3729], 'To': [2223, 3730], 'obtain': [2224, 3731], 'full-length': [2226, 3733, 3770], 'screened': [2229], 'kidney': [2232, 3708, 3747, 3992], 'library': [2234, 2388, 3709], '(Life': [2235, 2251, 2632, 3655], 'Technologies,': [2236, 2252, 2633, 3656], 'Grand': [2237, 2253, 2634, 3657], 'Island,': [2238, 2254, 2635, 3658], 'NY)': [2239, 2636, 3659], 'livin-specific': [2242], 'probe,': [2243, 3933], '5′-CCTTCTATGACTGGCCGCTGA-3′,': [2244], 'GeneTrapperTMcDNA': [2247], 'positive': [2248, 3740], 'selection': [2249, 3741], 'system': [2250, 3102, 3742], 'NY).': [2255], 'coding': [2257], 'PCR': [2262, 2281, 2313, 2334, 2364, 2380, 2399], 'cloned': [2263, 2375], 'pcDNA3.1/V5/His-TOPO': [2265, 2377], '(Invitrogen,': [2266, 2324, 2346, 3441], 'Carlsbad,': [2267, 2325, 2347, 3442], 'CA)': [2268, 2348, 2772, 3217, 3249, 3443, 3545], 'both': [2270], 'sense': [2272], 'orientations.': [2275], 'subsequently': [2278, 2511], 'subcloned': [2279, 2315, 2332, 2370], 'Bam': [2284], 'HI/Eco': [2285], 'RI': [2286], 'sites': [2287, 2321, 2428], 'pGEX-6P': [2289], '(Amersham': [2290, 2573, 2727, 3281, 3512], 'Pharmacia': [2291, 2574, 2728, 3282, 3513], 'Biotech,': [2292, 2575], 'Piscataway,': [2293, 2576, 3314], 'NJ)': [2294, 2577], 'purification': [2296], 'glutathioneS-transferase': [2299], 'fusion': [2300], 'protein.': [2301], '(ΔN154,': [2306], 'ΔC86,': [2307], '86–154)': [2309], 'generated': [2311, 2382], 'Kpn': [2318], 'I/Apa': [2319], 'I': [2320, 2357, 2427, 2776], 'within': [2322, 3995, 4322, 4493], 'pcDNA3.1/myc-His': [2323], 'CA).': [2326, 2392, 2501, 2752, 2821, 3141, 3463, 3582], 'DR6,': [2330, 4327], 'clones': [2337, 2479], '3334311,': [2338], '2057308,': [2339], '2733717': [2341], 'ligated': [2343, 2423], 'pTracer-SV40': [2345], 'atEco': [2349], 'RI/Not': [2350], 'I,': [2351, 2354], 'Eco': [2352], 'RV/Not': [2353], 'andNot': [2355], 'I/Spe': [2356], 'sites,': [2358], 'respectively.': [2359], 'Caspase-9': [2360, 3142], 'prepared': [2362, 2397, 2739, 3025, 3095, 3227, 3373, 3552, 3910], 'clone': [2367, 3753], '3590462': [2368], 'pcDNA3.1/V5/His-TOPO.': [2372], 'Apaf-1': [2373, 3094, 3146], 'product': [2381], 'testis': [2386], '(CLONTECH,': [2389, 2749], 'Palo': [2390, 2750, 2770], 'Alto,': [2391, 2751, 2771], 'pTracer-SV40-RIP': [2394], 'plasmid': [2395], 'pMH-RIP': [2401], '(34Kasof': [2402, 2440], 'Prosser': [2404, 2442], 'Lorenzi': [2408, 2446], 'M.V.': [2409, 2447], 'Gomes': [2410, 2448], 'B.C.': [2411, 2449], 'FEBS': [2412, 2450, 4374], 'Lett.': [2413, 2451, 4375], '473:': [2415, 2453], '285-291Crossref': [2416, 2454], '(97)': [2419, 2457], 'Scholar)': [2421, 4489], 'theKpn': [2425], 'I/Not': [2426], 'pTracer-SV40.': [2430], 'constructions': [2432], 'pTracer-SV40-RIP3': [2434], 'pZeoSV2-Bcl-xL': [2436], 'described': [2438, 3006, 3562], 'previously': [2439], 'pcDNA3.1-myc-survivin': [2460, 3363], 'provided': [2462], 'Dr.': [2464], 'Kevin': [2465], 'Hudson': [2466], '(AstraZeneca': [2467], 'Pharmaceuticals,': [2468], 'Macclesfield,': [2469], 'Cheshire,': [2470], 'UK).': [2471], 'nucleotide': [2473], 'sequences': [2474], 'confirmed': [2481], 'terminator': [2484], 'cycle': [2485], 'sequencing': [2486], 'automated': [2489], '377': [2490], 'sequencer': [2492], '(PerkinElmer': [2493], 'Life': [2494], 'Sciences': [2495], 'Applied': [2497], 'Biosystems,': [2498, 3066], 'Foster': [2499], 'City,': [2500], 'pGEX-6P-livin': [2502], 'inoculated': [2504], 'overnight': [2505, 2780], 'Escherichia': [2507], 'coli': [2508], 'BL21': [2509], 'stimulated': [2512], '0.5': [2514, 3251], 'mmisopropyl-1-thio-β-d-galactopyranoside': [2515], '4': [2517, 2546, 3275, 3427], 'h.': [2518], 'bacterial': [2520], 'pellet': [2521], 'resuspended': [2523], 'phosphate-buffered': [2525, 2844, 3621], 'saline': [2526], 'plus': [2527], 'lysozyme': [2528], '(1': [2529], 'mg/ml)': [2530], 'lysed': [2532], 'sonication.': [2534], 'Lysates': [2535], 'incubated': [2537, 2773, 3031, 3237, 3625], '1%': [2539, 2701, 3395, 3398], 'Triton': [2540, 3618], 'X-100': [2541, 3619], '30': [2543, 2861, 3168, 3285, 3424], 'min': [2544, 2862, 3425], 'at': [2545, 2621, 2692, 2781, 2796, 2810, 2863, 2915, 2925, 3053, 3073, 3080, 3167, 3274, 3419, 3426, 3642, 3663, 4021, 4212, 4319, 4345], '°C': [2547, 2694, 3276], 'then': [2549, 2718, 2787, 2867, 2973, 3196, 3290, 3614], 'centrifuged': [2550], 'remove': [2552], 'insoluble': [2554], 'material.': [2555], 'Supernatants': [2556], 'added': [2558], 'glutathione-Sepharose': [2561], '4B': [2562], 'column': [2563, 3138], 'bound': [2566], 'eluted': [2569], 'PreScission': [2571], 'protease': [2572, 3407], 'cleaving': [2579], 'glutathione': [2581], 'S-transferase': [2582], 'fusion.': [2583], 'HeLa,': [2584], 'G361,': [2585], 'SK-Mel29,': [2586, 4050], 'HMCB,': [2587, 2652], 'A375,': [2588, 2653], 'WM115,': [2589, 2654], 'HT144,': [2590], 'SW480': [2592], '(ATCC,': [2595], 'Rockville,': [2596], 'MD)': [2597, 2779], 'cultured': [2599], "Dulbecco's": [2601], 'modified': [2602], "Eagle's": [2603], 'medium': [2604], 'supplemented': [2605, 3404], '10%': [2607, 3188], 'fetal': [2608, 2743, 3707, 3989, 4007], 'bovine': [2609], 'serum': [2610], 'penicillin': [2612], '(100': [2613], 'units/ml)/streptomycin': [2614], '(0.1': [2615], 'mg/ml).': [2616], 'maintained': [2620, 3537], '37': [2622, 3054, 3643, 3664], '°C,': [2623, 2812], '5%': [2624], 'CO2.': [2625], 'Transfections': [2626], 'performed': [2628, 3089, 3206, 3518, 3560], 'LipofectAMINE': [2630], 'Plus': [2631], 'according': [2637, 2665, 2960, 3507], "manufacturer's": [2640, 2668, 2963, 3510], 'specifications.': [2641, 2669], 'Poly(A)': [2642, 2659], 'RNA': [2643, 2671, 2737], 'isolated': [2645, 3960], 'melanoma': [2648, 4045, 4078], '(SK-Mel29,': [2651], 'HT144)': [2656], 'Pure': [2660], 'kit': [2661, 3020], '(Ambion,': [2662], 'Austin,': [2663], 'TX)': [2664], 'denatured': [2673], 'sample': [2675], 'buffer': [2676, 3114, 3255, 3379, 3555], '(2.2': [2677], 'm': [2678, 2706, 3381], 'formaldehyde,': [2679, 2707], '50%': [2680, 3186], 'formamide,': [2681], '50': [2682, 2708, 2811, 3033, 3161, 3392], 'mm': [2683, 2689, 2709, 2715, 3117, 3122, 3125, 3128, 3132, 3157, 3257, 3262, 3265, 3387, 3390, 3393], 'MOPS': [2684, 2710], '(pH': [2685, 2711, 3119, 3259, 3384], '7.0),': [2686, 2712], '1': [2688, 2714, 3051, 3127, 3131, 3156, 3165, 3192, 3264, 3375, 3640, 3661, 3873], 'EDTA)': [2690], 'heated': [2691], '65': [2693], '10': [2696, 2848, 2976, 3121, 3152], 'min,': [2697], 'electrophoresed': [2698], 'agarose': [2702, 3457], '2.2': [2705], 'EDTA,': [2716, 3129, 3266, 3391], 'transferred': [2719], 'capillary': [2721], 'elution': [2722], 'onto': [2723, 3486], 'Hybond-N': [2724], 'nylon': [2725], 'filters': [2726, 2924], 'Biotech).': [2729, 3514], 'used': [2733, 2885, 3736], 'commercially': [2734], 'available': [2735], 'blots,': [2738], 'blots': [2754, 2785, 3516, 3558], 'hybridized': [2756], 'random': [2758], 'primed': [2759], 'radiolabeledlivin': [2760], '(full-length': [2761], '5′-': [2764], '3′-untranslated': [2766], 'region)': [2767], 'actin(CLONTECH,': [2769], 'Hybrisol': [2775], '(Oncor,': [2777], 'Gaithersburg,': [2778], '42': [2782], '°C.': [2783, 3055, 3169, 3428, 3644, 3665], 'washed': [2788, 3291, 3467], '2': [2790, 3389], '×': [2791, 2805, 3421], 'SSC': [2792, 2806], '+': [2793, 2807], '0.05%': [2794], 'SDS': [2795, 2809], 'room': [2797, 2864], 'temperature': [2798], 'followed': [2799, 3277, 3444], 'high': [2801], 'stringency': [2802], 'washing,': [2803], '0.1': [2804], '0.1%': [2808, 2857, 3402], 'visualized': [2814, 3197, 3668], 'PhosphorImager': [2817], '(Molecular': [2818], 'Dynamics,': [2819], 'Sunnyvale,': [2820], 'Viability': [2822], 'assessed': [2824, 3591], '(GFP)': [2830, 2928], 'marker': [2831, 2900], 'produced': [2832], 'pTracer-SV40-derived': [2834], 'vectors.': [2835], 'Transfected': [2836, 3533], 'fixed': [2839, 3184, 3609], '2%': [2841, 3611], 'paraformaldehyde': [2842, 3612], 'saline,': [2845], 'counterstained': [2846, 2974], 'μg/ml': [2849, 2853, 2977, 2982], 'propidium': [2850, 2894, 2978], 'iodide,': [2851], '200': [2852, 2981], 'RNase': [2854, 2983], 'A,': [2855, 2984], 'Tween': [2858], '20': [2859], 'temperature,': [2865], 'mounted': [2868], 'microscope': [2870, 2988, 3675], 'slides': [2871, 2989], 'Immu-mount': [2873], '(Shandon,': [2874], 'Pittsburgh,': [2875], 'PA).': [2876, 3688], 'laser': [2878, 2921, 3002], 'scanning': [2879, 3003], 'cytometer': [2880, 3004], '(CompuCyte,': [2881], 'Cambridge,': [2882, 3636], 'MA)': [2883, 3068, 3637], 'determine': [2887], 'percent': [2889, 2994], 'GFP-positive': [2891], 'iodide': [2895, 2979], 'staining': [2896], 'served': [2897], 'gating': [2903], 'population.': [2906], 'Relative': [2907], 'fluorescence': [2908], 'values': [2909], 'determined': [2911, 3342], 'excitation': [2914], '488': [2916], 'nm': [2917, 2927, 2931, 3075, 3328], 'argon': [2920], 'emission': [2923], '505–540': [2926], '614–639': [2930], '(propidium': [2932], 'iodide).': [2933], 'ability': [2935], 'againstlivin': [2938], 'examined': [2943], 'TdT-mediated': [2945], 'dUTP-X': [2946], 'nick': [2947], 'end': [2948], 'labeling': [2949], '(TUNEL).': [2950], 'Transiently': [2951], 'stained': [2955], 'fluorescein': [2957, 3650], 'isothiocyante-conjugated': [2958, 3651], 'dUTP': [2959], 'specifications': [2964, 3511], '(Roche': [2965, 3411], 'Molecular': [2966, 3412], 'Biochemicals,': [2967, 3413], 'Indianapolis,': [2968, 3414], 'IN).': [2969], 'collected': [2986], 'cytospin.': [2992], 'TUNEL-positive': [2996], 'evaluated': [2999], 'above': [3007, 3563], 'GFP.': [3009], 'Caspase': [3010], 'measured': [3013], 'ApoAlertTM': [3016], 'assay': [3019], '(CLONTECH).': [3021], 'Cytosolic': [3022], 'lysates': [3023, 3371, 3550], 'μm': [3034, 3153, 3540], 'substrate': [3038], '7-amino-4-trifluoromethyl': [3039], 'coumarin': [3040], '(AFC)': [3041], 'conjugated': [3042, 3455], 'site': [3047], 'Asp-Glu-Val-Asp': [3048], '(DEVD)': [3049], 'h': [3052, 3166, 3273, 3641, 3662], 'Hydrolyzed': [3056], 'AFC': [3057], 'detected': [3059, 3301, 3502, 3647, 3938, 4027], 'CytoFluorTM': [3062], '4000': [3063], 'fluorometer': [3064], '(PerSeptive': [3065], 'Framingham,': [3067], 'peak': [3070, 3077], 'excitation/band': [3071], 'width': [3072, 3079], '360/40': [3074], 'emission/band': [3078], '530/30': [3081], 'nm.': [3082], '[35S]methionine-labeled': [3091, 3219], 'TNT': [3098, 3230], 'T7': [3099, 3231], 'reticulocyte': [3100, 3232], 'lysate': [3101, 3233], '(Promega': [3103], 'Corp.,': [3104, 3497], 'Madison,': [3105, 3498, 3835], 'WI).': [3106, 3499], 'desalted': [3110], 'exchanged': [3112], '(20': [3116, 3256], 'HEPES': [3118], '7.5),': [3120], 'KCl,': [3123], '1.5': [3124, 3272], 'MgCl2,': [3126], 'dithiothreitol)': [3133], 'Bio-spin': [3136], 'P-6': [3137], '(Bio-Rad,': [3139], 'Hercules,': [3140], '(2': [3143], 'μl)': [3144, 3148], '(6': [3147], 'combined': [3150], 'cytochromec': [3154], 'dATP': [3158], '(Sigma)': [3159], 'μmrecombinant': [3162], 'samples': [3171, 3288, 3465], 'boiled': [3173], 'Laemmli': [3175, 3475, 3554], 'buffer,': [3176, 3296, 3472, 3476], 'resolved': [3178, 3297, 3478], '4–20%': [3180], 'SDS-PAGE.': [3181, 3480], 'Gels': [3182], 'methanol,': [3187], 'acetic': [3189], 'h,': [3193], 'dried,': [3194], 'PhosphorImager.': [3200, 3304], 'reactions': [3204], 'combining': [3208], '(PharMingen,': [3214, 3246], 'San': [3215, 3247], 'Diego,': [3216, 3248], '(wild-type': [3223], 'mutants),': [3226], 'system.': [3234], 'Samples': [3235], 'polyclonal': [3239], 'antibodies': [3240, 3565, 3627], 'either': [3242, 3360, 3435], 'ml': [3252, 3376], 'NETN': [3254, 3295], 'Tris': [3258], '8.0),': [3260], '100': [3261, 3539], 'NaCl,': [3263, 3388], '0.2%': [3268, 3617], 'Nonidet': [3269, 3396], 'P-40)': [3270], 'G-Sepharose': [3280, 3447], 'Biotech)': [3283], 'min.': [3286], 'times': [3293, 3469], 'SDS-PAGE,': [3299], 'Binding': [3305, 3339], 'kinetics': [3306], 'obtained': [3308], 'BiacoreTM': [3311], '3000': [3312], '(Biacore,': [3313], 'NJ).': [3315], 'Recombinant': [3316], 'amine': [3319], 'coupled': [3320], 'CM5': [3323], 'sensor': [3324], 'chip': [3325], '1–500': [3327], 'caspases-3,': [3330], '-9': [3333], 'passed': [3335], 'chip.': [3338], 'constants': [3340], 'BIAevaluation': [3345], 'software': [3346], '(version': [3347], '3.0).': [3348], 'Associations': [3349], 'pcDNA3.1/V5/His-TOPO-livin': [3361], 'treated': [3365], 'TNF-α': [3367], 'cycloheximide.': [3369], 'RIPA': [3378, 3471], '(0.01': [3380], 'sodium': [3382, 3399], 'phosphate': [3383], '7.2),': [3385], '150': [3386], 'NaF,': [3394], 'P-40,': [3397], 'deoxycholate,': [3400], 'SDS)': [3403], 'mixture': [3409], 'tablet': [3410], 'IN)': [3415], 'spun': [3418], '20,000': [3420], 'g': [3422], 'soluble': [3430], 'supernatants': [3431], 'immunoprecipitated': [3433], 'monoclonal': [3437, 3451, 3492], 'antibody': [3438, 3452, 3493, 3654], 'V5': [3440, 3630], 'Myc': [3454, 3632], '(Santa': [3458], 'Cruz': [3459], 'Biotechnology,': [3460], 'Santa': [3461], 'Cruz,': [3462], 'boilied': [3473], 'gels': [3482], 'semi-dry': [3484], 'blotted': [3485], 'nitrocelluose': [3487], 'probed': [3489], '(PanVera': [3496], 'Immuno-complexes': [3500], 'enhanced': [3504], 'chemiluminescence': [3505], '(ECL)': [3506], 'Western': [3515, 3557], 'confirm': [3520], 'reduce': [3527], 'expression,': [3529], 'Survivin.': [3532, 3853], 'ZVAD-fmk': [3541], '(Enzyme': [3542], 'Systems,': [3543, 3572], 'Livermore,': [3544], 'prevent': [3547], 'V5,': [3567], '(R': [3569], '&': [3570], 'D': [3571], 'Minneapolis,': [3573], 'MN),': [3574], 'glyceraldehyde-3-phosphate': [3576], 'dehydrogenase': [3577], '(Chemicon': [3578], 'International,': [3579], 'Inc.,': [3580, 3686], 'Temecula,': [3581], 'localizations': [3585], 'immunofluorescence': [3594], 'epitope-tagged': [3600], 'constructs.': [3602], 'Twenty-four': [3603], 'hours': [3604], 'post-transfection': [3605], 'permeabilized': [3615], 'saline.': [3622], 'Coverslips': [3623], '(Oncogene': [3633], 'Research': [3634], 'Products,': [3635], 'epitopes': [3638], 'Staining': [3645], 'goat': [3652], 'anti-mouse': [3653], 'Cells': [3666], 'epifluorescence': [3670], 'Olympus': [3673], 'AX70': [3674], 'equipped': [3676], 'Kodak': [3679], 'DCS': [3680], '520': [3681], 'digital': [3682], 'camera': [3683], '(Hitech': [3684], 'Instruments,': [3685], 'Edgemont,': [3687], 'search': [3691], 'BLAST,': [3699], 'revealed': [3700], '840-nucleotide': [3702], 'predicted': [3711, 3782], 'encode': [3713, 3784], 'gene,': [3734, 3773], 'GeneTrapperTM': [3738], 'screen': [3744], 'library.': [3749], 'low': [3751, 4024], 'abundant': [3752], 'contained': [3757, 3887], 'in-frame': [3759], 'stop': [3760], 'codon': [3761], '5′-untranslated': [3764], 'region,': [3765], 'suggesting': [3766, 3977], 'gene.': [3771], 'termedlivin,': [3776], '1297': [3778], 'pairs': [3780], '280-amino': [3786], '(Fig.1': [3789], 'A;': [3790], 'GenBank': [3791], 'accession': [3792], 'numberAF311388).': [3793], 'Genomic': [3794], 'corresponding': [3796, 4066], 'EMBL': [3805], 'AL121827)': [3810], 'localized': [3812], 'chromosome': [3814, 4065], '20.': [3815], 'overall': [3817], 'identity': [3819], 'GAP': [3830], 'pairwise': [3831], 'alignment': [3833], '(GCGTM,': [3834], 'WI)': [3836], '24.1%': [3838], '26.1%': [3841], '34.7%': [3844], '25.5%': [3847], '26.3%': [3851], 'At': [3854], 'structural': [3856], 'level': [3857, 4349], 'similar': [3860], 'respect': [3864, 4313], 'having': [3866], 'just': [3867], '(Fig.': [3872, 3948, 4058], 'B).': [3874], 'did': [3877], 'coiled-coil': [3881], 'like': [3883], 'rather': [3886], 'XIAP.': [3897], 'tissue': [3899], 'studied': [3904], 'blotting': [3907], 'Using': [3924], 'entire': [3926], 'distinct': [3935, 3971], 'mRNAs': [3936], 'approximate': [3940], 'sizes': [3941, 3965], '1.4,': [3943], '2.0,': [3944], '2.8': [3946], 'kilobases': [3947], '2).': [3949, 4059], 'smaller': [3951], 'transcripts': [3954, 3969], 'consistent': [3956], 'our': [3962], 'screen.': [3963], 'they': [3979], 'forlivin.': [3982], 'Despite': [3983], 'presence': [3985], 'libraries,': [3994], 'tested': [3999], 'here,livin': [4000], 'only': [4003], 'placenta': [4005], 'brain.': [4008], 'It': [4009], 'transcriptionally': [4016], 'tissues,': [4019, 4151], 'too': [4023], 'blot.': [4031], 'Elevated': [4032], 'seen': [4037], 'lesser': [4054], 'extent,': [4055], 'Interestingly,': [4060], 'segments': [4062], 'displays': [4071], 'increased': [4072], 'copy': [4073], 'primary': [4082], '(35Barks': [4084], 'J.H.': [4085, 4357], 'F.H.': [4087], 'Taetle': [4088], 'Yang': [4090], 'J.-M.': [4091], 'Stone': [4092], 'J.F.': [4093], 'Wymer': [4094], 'J.A.': [4095], 'Khavari': [4096], 'X.-Y.': [4099], 'Trent': [4100], 'Pinkel': [4102], 'Nelson': [4104], 'M.A.': [4105], 'Chromosome': [4107], 'Cancer.': [4108], '278-285Crossref': [4111], '(34)': [4114], 'narrower': [4121], 'thansurvivin': [4123], 'cells,': [4126], 'patterns': [4129], 'genes': [4134], 'similar,': [4136], 'no': [4138, 4221], 'developing': [4150], 'confer': [4198], 'interactions,': [4204], 'some': [4205], 'motifs': [4207], 'effective': [4211], 'suppressing': [4213], 'there': [4216], 'BIR-containing': [4218], 'apparent': [4222], 'function': [4224], '36Hauser': [4272], 'H.P.': [4273], 'Bardroff': [4274], 'Pyrowolakis': [4276], 'Jentsch': [4278], '141:': [4284], '1415-1422Crossref': [4285], '(205)': [4288], 'Therefore,': [4291], 'domain-containing': [4295], 'defined': [4299], 'properly': [4300], 'IAP.': [4303], 'potential': [4305], 'investigated': [4311], 'pro-apoptotic': [4316], 'signals': [4317], 'acting': [4318], 'different': [4320], 'points': [4321], 'process,': [4325], 'Bax.': [4332], 'DR6': [4333], 'TNF': [4339], 'thus': [4343], 'upstream': [4348], 'process': [4353], '(37Pan': [4354], 'Bauer': [4356], 'Haridas': [4358], 'V.': [4359], 'D.,': [4363], 'Yu,': [4364], 'Vincenz': [4366], 'Aggarwal': [4368], 'B.B.': [4369], 'Ni': [4370], 'Dixit': [4372, 4390, 4439], 'V.M.': [4373, 4391, 4440], '451:': [4377], '351-356Crossref': [4378], '(223)': [4380], 'FADD': [4383], '(38Chinnaiyan': [4384], "O'Rourke": [4386], 'Tewari': [4388], '81:': [4394, 4417], '505-512Abstract': [4395], '(2154)': [4401], 'Scholar),': [4403, 4426], 'RIP': [4404], '(39Stanger': [4405], 'B.Z.': [4406], 'Leder': [4407], 'Lee': [4409, 4431], 'T.-H.': [4410], 'Kim': [4411], 'Seed': [4413], '513-523Abstract': [4418], 'RIP3': [4428], '(40Sun': [4429], 'Navas': [4433], 'Baldwin': [4435], 'D.T.': [4436], 'Stewart': [4437], '274:': [4445], '16871-16875Abstract': [4446], '(179)': [4454], '41Yu': [4457], 'P.W.': [4458], 'Huang': [4459], 'B.C.B.': [4460], 'Shen': [4461], 'Quast': [4463], 'Chan': [4465], 'Xu': [4467], 'Nolan': [4469], 'G.P.': [4470], 'Payan': [4471], 'Luo': [4473], 'Curr.': [4475], '539-542Abstract': [4479], '(119)': [4487], 'adapter': [4491], 'pathway.': [4496], 'Bax': [4497], 'potent': [4500], 'inducer': [4501]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2049608177', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 13}, {'year': 2021, 'cited_by_count': 12}, {'year': 2020, 'cited_by_count': 20}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 8}, {'year': 2016, 'cited_by_count': 8}, {'year': 2015, 'cited_by_count': 7}, {'year': 2014, 'cited_by_count': 13}, {'year': 2013, 'cited_by_count': 26}, {'year': 2012, 'cited_by_count': 25}], 'updated_date': '2024-12-27T14:20:13.453833', 'created_date': '2016-06-24'}
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