Publication Information

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'https://openalex.org/P4310320256'], 'host_organization_lineage_names': ['Springer Nature', 'BioMed Central'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 2, 'referenced_works': ['https://openalex.org/W1969498104', 'https://openalex.org/W2042380755'], 'related_works': ['https://openalex.org/W768371444', 'https://openalex.org/W4327966545', 'https://openalex.org/W4211055382', 'https://openalex.org/W2529441838', 'https://openalex.org/W2437132565', 'https://openalex.org/W2204547784', 'https://openalex.org/W2107790148', 'https://openalex.org/W2096128739', 'https://openalex.org/W2021018323', 'https://openalex.org/W2016703262'], 'abstract_inverted_index': {'The': [0, 297, 344, 359, 570], 'human': [1, 393, 480], 'multidrug': [2, 199], 'resistance': [3, 200], 'protein': [4, 201, 259, 332, 557], '3': [5, 123], '(MDR3/ABCB4)': [6], 'belongs': [7], 'to': [8, 38, 60, 96, 162, 169, 186, 227, 397, 436, 442, 455, 524, 609, 625, 646, 661, 684, 687, 720, 743, 788, 869, 900, 983], 'the': [9, 26, 36, 39, 43, 62, 72, 100, 104, 109, 133, 138, 143, 152, 157, 163, 170, 187, 198, 217, 228, 241, 250, 257, 264, 287, 301, 329, 339, 355, 374, 406, 413, 437, 472, 479, 491, 576, 620, 629, 647, 662, 695, 698, 711, 734, 773, 778, 790, 804, 807, 814, 822, 827, 831, 838, 856, 864, 888, 894, 901, 905, 912, 989], 'ATP': [10, 48, 589, 691], 'binding': [11, 305, 312, 550, 866], 'cassette': [12], '(ABC)': [13], 'transporter': [14], 'family': [15, 333], 'found': [16, 514], 'in': [17, 25, 108, 212, 457, 484, 490, 496, 527, 582, 628, 678, 710, 728, 791, 893, 911], 'all': [18], 'kingdoms': [19], 'of': [20, 29, 42, 55, 106, 114, 130, 156, 167, 220, 230, 246, 253, 266, 300, 328, 342, 352, 357, 364, 389, 401, 408, 447, 482, 540, 579, 604, 635, 697, 767, 775, 821, 881, 914, 921], 'life.': [21], 'MDR3': [22, 139, 168, 181, 191, 303, 367, 390, 409, 433, 470, 483, 489, 526, 530, 581, 586, 674, 776, 854, 860, 915, 976], 'is': [23, 51, 58, 177, 182, 205, 261, 315, 325, 335, 410, 434, 623, 885, 936, 947], 'located': [24], 'canalicular': [27, 44, 188, 251, 340], 'membrane': [28, 45, 101, 172, 252, 341], 'hepatocytes': [30], 'and': [31, 57, 81, 102, 146, 165, 184, 207, 244, 268, 274, 334, 366, 391, 464, 471, 487, 513, 547, 568, 598, 613, 689, 702, 725, 738, 746, 757, 784, 799, 816, 842, 855, 872, 884, 916, 986], 'translocates': [32], 'phosphatidylcholine': [33], '(PC)': [34], 'from': [35, 65, 99], 'inner': [37], 'outer': [40], 'leaflet': [41], 'energized': [46], 'by': [47, 71, 84, 128, 412, 574, 596, 657, 830, 863], 'hydrolysis.': [49], 'PC': [50, 147, 659], 'one': [52, 134, 820], 'major': [53], 'component': [54], 'bile': [56, 66, 73, 79], 'essential': [59], 'protect': [61], 'biliary': [63, 110], 'duct': [64], 'salts,': [67], 'which': [68, 237, 283, 946], 'are': [69, 126, 235, 238], 'translocated': [70, 83], 'salt': [74], 'export': [75], 'pump': [76], '(BSEP/ABCB11).': [77], 'Phosphatidylcholine,': [78], 'salts': [80], 'cholesterol': [82, 107], 'ABCG5/G8': [85], 'form': [86], 'mixed': [87, 90, 812], 'micelles.': [88], 'These': [89], 'micelles': [91], 'have': [92, 848], 'a': [93, 316, 326, 380, 385, 392, 500, 548, 626, 679, 706, 721, 879, 940], 'lower': [94], 'capacity': [95], 'extract': [97, 525], 'lipids': [98, 660], 'prevent': [103], 'crystallization': [105], 'duct.': [111], 'Different': [112], 'types': [113], 'liver': [115, 394], 'diseases': [116], 'e.g.': [117], 'progressive': [118], 'familial': [119], 'intrahepatic': [120], 'cholestasis': [121], 'type': [122], '(PFIC': [124], '3)': [125], 'caused': [127], 'dysfunction': [129], 'MDR3.': [131, 323, 402, 818, 993], 'On': [132, 151], 'hand': [135, 154], 'mutations': [136], 'within': [137], 'gene': [140], 'can': [141, 173, 675, 973], 'abolish': [142], 'ATPase': [144, 577, 606, 616, 643, 654], 'activity': [145, 578, 591, 607, 644, 655], 'lipid': [148], 'transport,': [149], 'respectively.': [150], 'other': [153], 'defects': [155], 'regulation': [158, 218], 'pathway': [159], 'with': [160, 197, 384, 468, 533, 565, 682, 705, 740, 777, 813, 853, 944, 978, 992], 'respect': [161, 683], 'targeting': [164], 'retention': [166, 243], 'canliculare': [171], 'occur.': [174], 'Currently,': [175, 846], 'it': [176], 'not': [178, 964], 'known,': [179], 'how': [180, 432], 'regulated': [183, 411], 'targeted': [185, 435], 'membrane.': [189], 'Further,': [190, 980], 'shares': [192], 'over': [193, 506], '75': [194], '%': [195], 'identity': [196], '1': [202, 418], '(MDR1/ABCB1).': [203], 'MDR1': [204, 231], 'well-characterized': [206], 'plays': [208], 'an': [209, 425, 541, 615, 918], 'enormous': [210], 'challenge': [211], 'chemotherapy.': [213], 'If': [214], 'we': [215, 222, 440, 453, 477, 611, 693, 732, 786, 847, 909, 955, 962, 972, 981], 'identify': [216, 398, 443], 'mechanism': [219], 'MDR3,': [221, 945], 'will': [223], 'as': [224, 424, 519], 'well': [225], 'contribute': [226], 'understanding': [229], 'regulation.\r\n\r\nSeveral': [232], 'adaptor': [233, 258, 699], 'proteins': [234, 400, 700, 736, 823], 'identified,': [236], 'important': [239], 'for': [240, 263, 272, 276, 415, 428, 499, 925], 'incorporation,': [242], 'degradation': [245], 'ABC': [247], 'transporters': [248], 'into': [249], 'hepatocytes.': [254, 343], 'For': [255, 450, 803], 'example,': [256], 'NHERF-1': [260, 278, 320, 701, 737, 985], 'crucial': [262], 'internalization': [265], 'MRP2': [267, 273, 365], 'MRP4,': [269], 'Radixin': [270], '(RDX)': [271], 'HAX-1': [275], 'BSEP.': [277], 'contains': [279, 308], 'two': [280], 'PDZ': [281], 'domains,': [282], 'binds': [284, 321, 354, 898], 'amongst': [285], 'others': [286], 'highly': [288, 630, 941], 'conserved': [289, 370, 631], 'motive': [290, 634], '(S/T)X(V/I/L/A/F/M)': [291], '(X': [292], '=': [293], 'any': [294, 602], 'amino': [295, 360, 371], 'acid).': [296], 'primary': [298], 'sequence': [299, 362], 'second': [302], 'nucleotide': [304], 'domain': [306, 351], '(NBD)': [307], 'several': [309, 835], 'times': [310], 'this': [311, 448, 451, 953, 969], 'motive.': [313], 'This': [314, 638], 'first': [317, 970], 'hint': [318], 'that': [319, 405, 515, 592, 671, 937, 975], 'also': [322, 727], 'RDX': [324, 353, 703, 739, 783, 987], 'member': [327], 'Ezrin/Radixin/Moesin': [330], '(ERM)': [331], 'mainly': [336], 'localized': [337], 'at': [338, 373, 887, 931], 'N-terminale': [345], 'FERM': [346], '(4.1-protein,': [347], 'Erzin,': [348], 'Radixin,': [349], 'Moesin)': [350], 'C-terminus': [356], 'MRP2.': [358], 'acid': [361, 622], 'alignment': [363], 'showed': [368, 641], 'no': [369, 653], 'acids': [372], 'C-terminus.\r\n\r\nIkebuchi': [375], 'Y.': [376], 'et': [377], 'al.': [378], 'used': [379, 422], 'yeast-two': [381], 'hybrid': [382], 'screen': [383], 'cytoplasmatic': [386], 'linker': [387], 'region': [388], 'cDNA': [395, 481, 696, 717], 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'cerevisiae': [486], 'expressed': [488, 673, 726], 'methylotrophic': [492], 'yeast': [493], 'Pichia': [494], 'pastoris': [495], 'amounts': [497], 'suitable': [498], 'detailed': [501], 'structure-function': [502], 'analysis.': [503], 'tested': [505], '100': [507, 559], 'different': [508], 'detergents': [509, 518], 'via': [510, 535, 751, 844], 'dotblot': [511], 'analysis': [512], 'only': [516], 'lipid-like': [517], 'Fos-cholines': [520], '(FCs)': [521], 'were': [522, 563], 'able': [523], 'adequate': [528], 'yields.': [529], 'was': [531, 572, 664, 718, 749, 811, 824, 840, 861], 'FC-16': [534], 'tandem-affinity': [536], 'purification': [537, 552, 756], '(TAP)': [538], 'consisting': [539], 'immobilized': [542, 752, 825, 862], 'metal': [543, 753], 'ion': [544, 754], 'affinity': [545, 708, 723, 755, 832], 'calmodulin': [549, 865, 870], 'peptide': [551, 867], 'step.': [553], 'About': [554], '6': [555], 'mg': [556, 765], 'per': [558], 'g': [560], 'wet': [561], 'cells': [562], 'obtained': [564, 762, 886], 'high': [566, 744], 'purity': [567, 745], 'homogeneity.': [569], 'functionality': [571], 'measuring': [575], 'detergent': [583], 'solution.': [584], 'Purified': [585], 'exhibited': [587], 'significant': [588], 'hydrolysis': [590], 'could': [593], 'be': [594, 676], 'stimulated': [595], 'DPPC': [597], 'DOPC.': [599], 'To': [600, 951], 'eliminate': [601], 'possibility': [603], 'unspecific': [605], 'due': [608], 'contaminants,': [610], 'inactive': [617], 'mutant,': [618], 'where': [619], 'glutamic': [621], 'changed': [624], 'glutamine': [627], 'Walker': [632], 'B': [633], 'both': [636], 'NBDs.': [637], 'mutant': [639], '(E558Q/E1027Q)': [640], 'basal': [642], 'comparable': [645], 'wild-type': [648], 'protein.': [649], 'But': [650], 'more': [651], 'important,': [652], 'stimulation': [656], 'adding': [658, 875], 'reaction': [663, 913], 'obtained.': [665], 'So': [666], 'far': [667], 'work': [669], 'demonstrates': [670], 'heterologously': [672], 'functional': [680, 817], 'state': [681], 'its': [685], 'capability': [686], 'bind': [688], 'hydrolyze': [690], '[2].\r\n\r\nSecond,': [692], 'combined': [704], 'StrepII': [707], 'tag': [709, 724], 'Escherichia': [712], 'coli': [713], 'expression': [714], 'system.': [715], 'fused': [719], 'hexa-histidine': [722], 'E.': [729], 'coli.': [730], 'Recently,': [731], 'Strep-tactin': [741], 'sepharose': [742], 'homogenity.': [747], 'chromatography.': [760], 'approximately': [763], '20': [764], 'out': [766], '2': [768], 'L': [769], 'cell': [770], 'culture.\r\n\r\nTo': [771], 'determine': [772], 'putative': [779], 'NHERF-1,': [782], 'pull-down': [793, 805, 851], 'assay,': [794, 806], '(SEC)': [798], 'page.': [802], 'partner': [810], 'Then': [819], 'on': [826], 'corresponding': [828], 'matrix': [829], 'tag.': [833], 'After': [834], 'washing': [836], 'steps,': [837], 'complex': [839, 943], 'eluted': [841, 873], 'identified': [843], 'immunoblotting.': [845], 'done': [849], 'initial': [850], 'assays': [852], 'positive': [857], 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