Publication Information

{'id': 'https://openalex.org/W2049237004', 'doi': 'https://doi.org/10.1021/jm00104a013', 'title': 'New bronchodilators. 3. Imidazo[4,5-c][1,8]naphthyridin-4(5H)-ones', 'display_name': 'New bronchodilators. 3. Imidazo[4,5-c][1,8]naphthyridin-4(5H)-ones', 'publication_year': 1992, 'publication_date': '1992-12-01', 'ids': {'openalex': 'https://openalex.org/W2049237004', 'doi': 'https://doi.org/10.1021/jm00104a013', 'mag': '2049237004', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/1479586'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/jm00104a013', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S162030435', 'display_name': 'Journal of Medicinal Chemistry', 'issn_l': '0022-2623', 'issn': ['0022-2623', '1520-4804'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5103073760', 'display_name': 'Fumio Suzuki', 'orcid': 'https://orcid.org/0000-0003-4072-732X'}, 'institutions': [{'id': 'https://openalex.org/I205823427', 'display_name': 'Kyowa Kirin (Japan)', 'ror': 'https://ror.org/000wej815', 'country_code': 'JP', 'type': 'company', 'lineage': ['https://openalex.org/I205823427']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Fumio Suzuki', 'raw_affiliation_strings': ['Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., Shizuoka, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., Shizuoka, Japan.', 'institution_ids': ['https://openalex.org/I205823427']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112075427', 'display_name': 'Takeshi Kuroda', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Takeshi Kuroda', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112447301', 'display_name': 'Takashi Kawakita', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Takashi Kawakita', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111813219', 'display_name': 'Haruhiko Manabe', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Haruhiko Manabe', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111619216', 'display_name': 'Shigeto Kitamura', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Shigeto Kitamura', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108195536', 'display_name': 'Kenji Ohmori', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Kenji Ohmori', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108220440', 'display_name': 'Michio Ichimura', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Michio Ichimura', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022951213', 'display_name': 'Hiroshi Kase', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Hiroshi Kase', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5113618680', 'display_name': 'Shunji Ichikawa', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Shunji Ichikawa', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.284, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 27, 'citation_normalized_percentile': {'value': 0.84941, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 87, 'max': 88}, 'biblio': {'volume': '35', 'issue': '26', 'first_page': '4866', 'last_page': '4874'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T13160', 'display_name': 'Synthesis and Biological Evaluation', 'score': 0.9673, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, 'topics': [{'id': 'https://openalex.org/T13160', 'display_name': 'Synthesis and Biological Evaluation', 'score': 0.9673, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T12191', 'display_name': 'Chemical Reaction Mechanisms', 'score': 0.9603, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T14459', 'display_name': 'Synthesis and Reactions of Organic Compounds', 'score': 0.942, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.97680855}, {'id': 'https://openalex.org/C21951064', 'wikidata': 'https://www.wikidata.org/wiki/Q899212', 'display_name': 'Combinatorial chemistry', 'level': 1, 'score': 0.40715268}, {'id': 'https://openalex.org/C71240020', 'wikidata': 'https://www.wikidata.org/wiki/Q186011', 'display_name': 'Stereochemistry', 'level': 1, 'score': 0.3781895}, {'id': 'https://openalex.org/C155647269', 'wikidata': 'https://www.wikidata.org/wiki/Q243455', 'display_name': 'Medicinal chemistry', 'level': 1, 'score': 0.36231765}], 'mesh': [{'descriptor_ui': 'D001993', 'descriptor_name': 'Bronchodilator Agents', 'qualifier_ui': 'Q000138', 'qualifier_name': 'chemical synthesis', 'is_major_topic': True}, {'descriptor_ui': 'D007093', 'descriptor_name': 'Imidazoles', 'qualifier_ui': 'Q000138', 'qualifier_name': 'chemical synthesis', 'is_major_topic': True}, {'descriptor_ui': 'D009287', 'descriptor_name': 'Naphthyridines', 'qualifier_ui': 'Q000138', 'qualifier_name': 'chemical synthesis', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001993', 'descriptor_name': 'Bronchodilator Agents', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D001993', 'descriptor_name': 'Bronchodilator Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001993', 'descriptor_name': 'Bronchodilator Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D004347', 'descriptor_name': 'Drug Interactions', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006168', 'descriptor_name': 'Guinea Pigs', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007093', 'descriptor_name': 'Imidazoles', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D007093', 'descriptor_name': 'Imidazoles', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D007093', 'descriptor_name': 'Imidazoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009126', 'descriptor_name': 'Muscle Relaxation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009126', 'descriptor_name': 'Muscle Relaxation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D009130', 'descriptor_name': 'Muscle, Smooth', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D009130', 'descriptor_name': 'Muscle, Smooth', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009287', 'descriptor_name': 'Naphthyridines', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D009287', 'descriptor_name': 'Naphthyridines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009287', 'descriptor_name': 'Naphthyridines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D010726', 'descriptor_name': 'Phosphodiesterase Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D010726', 'descriptor_name': 'Phosphodiesterase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010726', 'descriptor_name': 'Phosphodiesterase Inhibitors', 'qualifier_ui': 'Q000138', 'qualifier_name': 'chemical synthesis', 'is_major_topic': False}, {'descriptor_ui': 'D010726', 'descriptor_name': 'Phosphodiesterase Inhibitors', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D013329', 'descriptor_name': 'Structure-Activity Relationship', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014132', 'descriptor_name': 'Trachea', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D014132', 'descriptor_name': 'Trachea', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/jm00104a013', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S162030435', 'display_name': 'Journal of Medicinal Chemistry', 'issn_l': '0022-2623', 'issn': ['0022-2623', '1520-4804'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/1479586', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4391375266', 'https://openalex.org/W4387497383', 'https://openalex.org/W2948807893', 'https://openalex.org/W2778153218', 'https://openalex.org/W2748952813', 'https://openalex.org/W2527526854', 'https://openalex.org/W2078814861', 'https://openalex.org/W1986764834', 'https://openalex.org/W1976181487', 'https://openalex.org/W1531601525'], 'abstract_inverted_index': {'In': [0], 'order': [1], 'to': [2, 36, 133, 142, 193], 'develop': [3], 'new': [4, 20, 204], 'oral': [5], 'bronchodilators,': [6], 'a': [7, 203], 'series': [8, 197], 'of': [9, 18, 70, 103, 189, 198, 206], 'novel': [10, 199], 'imidazol[4,5-c][1,8]naphthyridin-4(5H)-ones': [11], '5': [12], 'were': [13], 'designed': [14], 'and': [15, 29, 43, 58, 68, 121, 172], 'synthesized.': [16], 'Some': [17], 'these': [19, 82, 190], 'heterocycles': [21, 201], 'exhibited': [22], 'more': [23], 'potent': [24, 47], 'bronchodilator': [25], 'activity': [26], 'in': [27, 30, 125], 'vitro': [28], 'vivo': [31], 'than': [32, 137], 'theophylline.': [33], 'With': [34], 'respect': [35], 'modification': [37], 'at': [38, 52, 64, 158, 182], 'the': [39, 65, 71, 145, 186], '5-position,': [40], 'both': [41], 'phenyl': [42], 'n-butyl': [44], 'substitution': [45, 63], 'produced': [46], 'activity.': [48, 75], 'Though': [49], 'bulk': [50], 'tolerance': [51], 'N-3': [53], 'is': [54], 'observed': [55], 'with': [56], 'short': [57], 'small': [59], 'lipophilic': [60], 'groups,': [61], 'any': [62, 153], 'other': [66], 'positions': [67], 'transformations': [69], 'parent': [72], 'skeleton': [73], 'eliminated': [74], 'Thus': [76, 139], '5-phenyl-1H-imidazo[4,5-c][1,8]naphthyridin-4(5H)-one': [77], '(23)': [78], '(KF17625),': [79], 'which': [80], 'satisfied': [81], 'conditions,': [83], 'was': [84], 'selected': [85], 'for': [86], 'further': [87], 'studies': [88], '(antigen': [89], 'inhalation-induced': [90], 'bronchospasm': [91], 'model;': [92], 'minimum': [93], 'effective': [94], 'dose': [95], '(MED)': [96], '=': [97, 109, 169], '1': [98], 'mg/kg,': [99], 'po;': [100], 'antigen-induced': [101], 'contraction': [102, 120], 'trachea': [104], '(the': [105], 'Schultz-Dale': [106], 'reaction),': [107], 'IC50': [108], '2.2': [110], 'microM).': [111, 184], 'Compound': [112], '23': [113, 149], 'inhibited': [114, 162], 'carbachol-,': [115], 'histamine-,': [116], 'or': [117], 'leukotriene': [118], 'D4-induced': [119], 'relaxed': [122], 'spontaneous': [123], 'tone': [124], 'guinea': [126], 'pig': [127], 'isolated': [128], 'tracheal': [129, 164], 'preparations': [130], 'with,': [131], '4-': [132], '16-fold': [134], 'greater': [135], 'potency': [136], 'aminophylline.': [138], 'it': [140], 'appeared': [141], 'relax': [143], 'directly': [144], 'airway': [146], 'smooth': [147], 'muscle.': [148], 'did': [150], 'not': [151], 'have': [152], 'influence': [154], 'on': [155], 'adenosine': [156], 'binding': [157], '10': [159, 183], 'microM,': [160], 'but': [161], 'canine': [163], 'phosphodiesterase': [165], '(PDE)': [166], 'IV': [167], '(IC50': [168], '12': [170], 'microM)': [171], 'concanavalin-A-induced': [173], 'histamine': [174], 'release': [175], 'from': [176], 'rat': [177], 'mast': [178], 'cells': [179], '(44%': [180], 'inhibition': [181], 'Although': [185], 'detailed': [187], 'mechanisms': [188], 'compounds': [191], 'remain': [192], 'be': [194], 'elucidated,': [195], 'this': [196], 'tricyclic': [200], 'represents': [202], 'class': [205], 'bronchodilator.': [207]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2049237004', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}], 'updated_date': '2024-12-11T19:02:31.707465', 'created_date': '2016-06-24'}