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845, 857, 868, 886, 899, 906, 966, 970, 975, 981, 1005, 1016, 1086, 1090, 1094, 1101, 1106, 1171, 1178, 1185, 1192, 1202, 1244, 1252, 1271, 1306, 1311, 1394, 1490, 1552, 1562, 1572, 1596, 1599, 1610, 1613, 1622, 1626, 1641, 1649, 1660, 1672, 1688, 1696, 1719, 1725, 1735, 1738, 1753, 1758, 1772, 1777, 1839, 1847, 1850, 1891, 1988, 2009, 2135, 2138, 2177, 2247, 2285, 2291, 2295, 2317, 2376, 2447, 2564, 2603, 2611, 2637, 2653, 2694, 2794, 2815, 2849, 2895, 2899, 2908, 2913, 2950, 2954, 3059, 3062, 3079, 3205, 3209, 3213, 3224, 3331, 3339, 3359, 3362, 3436, 3481, 3526, 3530, 3541, 3623, 3635, 3647, 3655, 3659, 3671, 3677, 3683, 3714, 3720, 3732, 3756, 3762, 3801, 3807, 3810, 3827, 3879, 3893, 3895, 3905, 3914, 3917, 3923, 3933, 3938, 3968, 4004, 4013, 4024, 4061, 4074, 4084, 4093, 4097, 4181, 4192, 4205, 4216, 4222, 4230, 4243], 'specificity': [9, 209, 247, 447, 885, 1609, 1659, 1718, 1737, 3878, 4221], 'a': [11, 203, 249, 441, 482, 602, 670, 706, 1200, 1272, 1623, 1889, 2006, 2110, 2152, 2308, 2374, 2577, 2635, 2654, 2668, 2738, 3669, 3785, 3836, 3924, 3934, 4014, 4025, 4052], 'class': [12, 250], 'peptidoglycan': [14, 25, 195, 252, 263, 433, 480, 522, 750, 808, 840, 858, 887, 1156, 1193, 1307, 1574, 1673, 1724, 1739, 2316, 2440, 3214, 3517, 3531, 3684, 3894, 3915, 4085], 'cross-linking': [15, 139, 153, 253, 377, 391, 888, 1157, 1194, 1563, 1575, 1671, 1740, 3364, 3518, 3960, 4218], 'enzymes,': [16, 254], 'l,d-transpeptidases,': [18, 256], 'for': [19, 146, 163, 257, 384, 401, 890, 1029, 1400, 1487, 1589, 1593, 1634, 2016, 2244, 2439, 2458, 2661, 3675, 3744, 3778, 3873, 4238], 'highly': [21, 259, 849], 'diverse': [22, 260], 'structure': [23, 193, 261, 431, 856, 3358, 3713, 3761], 'precursors': [26, 196, 264, 434, 809, 841, 908, 1007, 1036, 1308, 1347, 1567, 3215, 3282, 3532, 3916], 'Gram-positive': [28, 266, 769, 960, 1409, 3918], 'bacteria.': [29, 267], 'The': [30, 141, 268, 379, 476, 502, 521, 655, 742, 781, 800, 884, 1549, 1658, 1875, 1935, 2022, 2127, 2154, 2217, 2304, 2342, 2422, 2436, 2509, 2562, 2657, 2692, 2728, 2809, 2847, 2997, 3038, 3146, 3328, 3416, 3444, 3479, 3716, 3738, 3760, 3787, 3798, 3901, 4220], 'lone': [31, 269], 'functionally': [32, 270], 'characterized': [33, 271], 'member': [34, 272], 'this': [36, 274, 1258, 1478, 1606, 3371, 3473], 'new': [37, 275], 'family': [38, 276, 1314, 1761, 3674], 'active': [40, 278, 714, 1493, 1775], 'site': [41, 279, 715], 'cysteine': [42, 280], 'peptidases,': [43, 281], 'Ldtfm': [44, 71, 114, 168, 282, 309, 352, 406, 1611, 1661, 1703, 1778, 3206, 3374, 3501, 3880, 4010, 4202, 4223], 'from': [45, 73, 113, 283, 311, 351, 1276, 1676, 1709, 1721, 1779, 2048, 2314, 2356, 2373, 2430, 2623, 3629, 3637, 3766], 'Enterococcus': [46, 284, 1107], 'faecium,': [47, 285, 1681, 3276], 'was': [48, 160, 286, 398, 1616, 1662, 1785, 1868, 1878, 1939, 2003, 2014, 2046, 2102, 2129, 2156, 2209, 2226, 2232, 2251, 2301, 2312, 2428, 2567, 2606, 2659, 2702, 2731, 2796, 2945, 3001, 3041, 3066, 3082, 3100, 3334, 3493, 3687, 3728, 3764, 3833, 3881, 4040, 4067], 'previously': [49, 287, 1801, 2183, 2456, 2859], 'shown': [50, 288, 3535], 'to': [51, 62, 66, 84, 120, 136, 157, 202, 232, 289, 300, 304, 322, 358, 374, 395, 440, 470, 680, 763, 768, 803, 901, 1180, 1278, 1345, 1352, 1565, 1601, 1715, 1981, 2005, 2449, 3055, 3154, 3280, 3343, 3355, 3512, 3536, 3651, 3663, 3726, 3752, 3965, 4042, 4187, 4198], 'bypass': [52, 290, 1201], 'd,d-transpeptidase': [54, 292, 745, 795], 'activity': [55, 293, 1015, 1551, 2793], 'classical': [58, 296], 'penicillin-binding': [59, 297, 535, 569, 661], 'proteins': [60, 298, 662], 'leading': [61, 299], 'high': [63, 301, 558, 592, 1207], 'level': [64, 302, 1208], 'cross-resistance': [65, 303], 'glycopeptide': [67, 305, 1102, 2382], 'and': [68, 77, 94, 115, 129, 183, 306, 315, 332, 353, 367, 421, 596, 639, 674, 720, 744, 773, 788, 810, 818, 842, 865, 1021, 1174, 1266, 1297, 1343, 1454, 1592, 1603, 1612, 1632, 1646, 1656, 1684, 1712, 1766, 1770, 1790, 1796, 1873, 1882, 1885, 1974, 2012, 2038, 2214, 2223, 2230, 2274, 2344, 2372, 2445, 2494, 2556, 2634, 2676, 2743, 2804, 2841, 2856, 2906, 2995, 3093, 3105, 3109, 3160, 3164, 3229, 3287, 3347, 3375, 3442, 3455, 3522, 3544, 3658, 3691, 3696, 3772, 3781, 3789, 3803, 3819, 3851, 3931, 3940, 3948, 3983, 3987, 4019, 4023, 4033, 4196, 4246], 'β-lactam': [69, 307, 1030, 1209, 1401], 'antibiotics.': [70, 308], 'homologues': [72, 310, 1704], 'Bacillus': [74, 312, 1682], 'subtilis': [75, 313, 1714, 2179, 2632], '(LdtBs)': [76, 314, 2633], 'E.': [78, 109, 316, 347, 943, 1045, 1627, 1630, 1685, 1710, 1780, 1788, 1851, 1942, 2235, 2248, 2318, 2357, 2431, 2495, 2624, 2627, 2900, 2903, 3006, 3219, 3275, 3332, 3350, 3426, 3542, 3624, 3630, 3638, 3946, 3951], 'faecalis': [79, 317, 1628, 1711, 1852, 2358, 2628, 2901, 3220, 3333, 3543], '(Ldtfs)': [80, 318], 'were': [81, 144, 319, 382, 1707, 1976, 2024, 2041, 2069, 2287, 2354, 2512, 2711, 2725, 2747, 2852, 3095, 3149, 3533, 3642, 3700, 3903], 'found': [82, 320, 3494, 3909], 'cross-link': [85, 323, 642, 3468], 'their': [86, 147, 324, 385, 1578, 3757], 'cognate': [87, 148, 165, 325, 386, 403, 2828], 'disaccharide-peptide': [88, 326, 3977, 4047], 'subunits': [89, 327, 859], 'containing': [90, 328, 1638, 1998, 2034, 2077, 2123, 2167, 2270, 2424, 2519, 2618, 2644, 2830, 3051, 3472, 4016, 4027], 'meso-diaminopimelic': [91, 329, 543, 577, 1263, 2425], 'acid': [92, 330, 598, 1255, 1264, 1338, 2426, 2521, 2571, 4082], '(mesoDAP3)': [93, 331, 2427], 'l-Lys3-l-Ala-l-Ala': [95, 184, 333, 422, 3949], 'at': [96, 334, 621, 977, 1240, 1257, 1692, 1978, 1985, 2019, 2098, 2158, 2276, 2649, 2664, 3072, 3076, 3084, 3709, 3735, 3793, 3910], 'third': [98, 336, 691, 866, 1242, 1694, 2651, 3912], 'position': [99, 337, 980, 1243, 1695, 2652, 3913], 'stem': [102, 340, 604, 672, 696, 728, 871, 1247, 1636, 1698, 3799, 3806, 4021, 4028, 4195], 'peptide,': [103, 341], 'respectively,': [104, 342], 'instead': [105, 343, 974, 1640, 3435], 'l-Lys3-d-iAsn': [107, 172, 182, 345, 410, 420, 1642], 'in': [108, 134, 151, 185, 346, 372, 389, 423, 851, 854, 959, 1018, 1104, 1110, 1158, 1408, 1411, 1418, 1458, 1629, 1643, 1652, 1665, 1748, 1787, 1941, 1990, 2028, 2161, 2234, 2253, 2279, 2516, 2608, 2681, 2697, 2700, 2713, 2812, 2902, 3043, 3207, 3218, 3353, 3370, 3425, 3448, 3495, 3506, 3510, 3547, 3644, 3723, 3876, 3928, 3945, 3950, 3995, 4058, 4090, 4177, 4207, 4212, 4225, 4227, 4240, 4249], 'faecium.': [110, 348], 'Ldtfs': [111, 349, 1754, 2045, 2795, 2824], 'differed': [112, 350, 3792], 'LdtBs': [116, 176, 354, 414, 2231, 2250], 'by': [117, 173, 181, 355, 411, 419, 601, 627, 634, 660, 689, 778, 812, 916, 1088, 1309, 1348, 1404, 1416, 1654, 1667, 1792, 2026, 2043, 2053, 2105, 2142, 2256, 2307, 2348, 2514, 2558, 2569, 2678, 2704, 2749, 2799, 2854, 3003, 3097, 3158, 3162, 3221, 3283, 3373, 3376, 3453, 3484, 3498, 3539, 3702, 3730, 3774, 3784, 3796, 3835, 3843, 3855, 3883, 3891, 4031, 4072, 4077], 'its': [118, 164, 356, 402, 843, 1586], 'capacity': [119, 357], 'hydrolyze': [121, 359], 'l-Lys3-d-Ala4': [123, 361, 1168], 'bond': [124, 362, 668, 1170], 'tetrapeptide': [126, 364, 1154, 2655, 3816], '(l,d-carboxypeptidase': [127, 365], 'activity)': [128, 132, 366, 370], 'pentapeptide': [130, 368, 673, 870, 982, 1095, 3821], '(l,d-endopeptidase': [131, 369], 'stems,': [133, 371], 'addition': [135, 373], 'common': [138, 376], 'activity.': [140, 378], 'three': [142, 380, 1677, 2638, 3888, 3896, 3957, 3972], 'enzymes': [143, 381, 889, 918, 1564, 1576, 1720, 1741], 'specific': [145, 162, 383, 400, 3753], 'acyl': [149, 166, 187, 219, 387, 404, 425, 457, 2807, 2837], 'acceptors': [150, 388], 'reaction.': [154, 392, 4219], 'In': [155, 393, 1605, 1750, 3274, 3824], 'contrast': [156, 394, 3511], 'Ldtfs,': [158, 396, 1867, 2096], 'which': [159, 397], 'also': [161, 399, 1009, 1663, 1763, 2797, 3457, 3534, 4136], 'donor,': [167, 405], 'tolerated': [169, 177, 407, 415, 915, 3502, 3538, 4203], 'substitution': [170, 178, 408, 416, 3504], 'l-Lys3-l-Ala-l-Ala.': [174, 412], 'Likewise,': [175, 413], 'mesoDAP3': [180, 418, 2648], 'donor.': [188, 426], 'Thus,': [189, 427, 3500, 4201], 'diversification': [190, 428], 'associated': [197, 435], 'with': [198, 436, 511, 1034, 1153, 1568, 1577, 1870, 1880, 2065, 2092, 2117, 2131, 2211, 2221, 2443, 2451, 2576, 2733, 3068, 3102, 3107, 3421, 3519, 3689, 3693, 3887, 3899], 'speciation': [199, 437], 'has': [200, 438, 1195, 1580], 'led': [201, 439], 'parallel': [204, 442], 'evolution': [205, 443], 'substrate': [208, 446, 1320, 3361, 4057, 4215], 'l,d-transpeptidases': [212, 450], 'affecting': [213, 451], 'mainly': [214, 452, 861], 'recognition': [216, 454], 'acceptor.': [220, 458], 'Blocking': [221, 459], 'assembly': [223, 461, 837], 'side': [226, 464, 686, 1182, 1273, 1304, 1396, 1570, 2351, 2833, 3211, 3446, 3528, 3681, 3925, 3935, 4190], 'chain': [227, 465, 687, 1183, 1274, 1305, 2352, 2834, 3212, 3529, 3682, 3926, 3936, 4191], 'could': [228, 466, 3748], 'therefore': [229, 467], 'be': [230, 468, 914, 3368, 3537, 3750], 'used': [231, 469, 530, 564, 2298, 2438, 2722, 3979, 3994, 4050], 'combat': [233, 471], 'antibiotic': [234, 472], 'resistance': [235, 473, 900, 1031, 1103, 1210, 1402, 1414, 1600, 2383], 'involving': [236, 474], 'l,d-transpeptidases.': [237, 475], 'bacterial': [477, 1678], 'cell': [478, 510, 623, 2039, 4233], 'wall': [479, 4234], 'is': [481, 504, 625, 658, 893, 1097, 1339, 1398, 3216, 3278, 3742, 3978, 4087], 'net-like': [483], 'macromolecule': [484], 'that': [485, 629, 641, 664, 776, 896, 909, 956, 1165, 1205, 1315, 1756, 2719, 3231, 3366, 3461, 3515, 3747, 4009], 'surrounds': [486], 'cytoplasmic': [488], 'membrane': [489], '(1Holtje': [490], 'J.V.': [491], 'Microbiol.': [492, 826, 924, 947, 991, 1049, 1468], 'Mol.': [493, 1467], 'Biol.': [494, 1069, 1134, 1225, 1326, 1378, 1822, 1912, 2406, 2479, 2541, 2777, 2880, 2978, 3023, 3131, 3185, 3259, 3313, 3401, 3572, 3606, 4119, 4160], 'Rev.': [495, 877, 1287], '1998;': [496], '62:': [497, 2203], '181-203Crossref': [498], 'PubMed': [499, 614, 652, 832, 881, 930, 998, 1079, 1144, 1235, 1291, 1334, 1388, 1434, 1449, 1472, 1511, 1544, 1832, 1864, 1922, 1969, 2337, 2369, 2416, 2489, 2504, 2551, 2598, 2787, 2890, 2940, 2988, 3033, 3141, 3195, 3269, 3323, 3411, 3582, 3616, 4129, 4170], 'Google': [500, 615, 653, 740, 835, 882, 933, 952, 1001, 1054, 1082, 1147, 1238, 1292, 1335, 1391, 1437, 1452, 1475, 1514, 1547, 1835, 1865, 1925, 1972, 2207, 2340, 2370, 2419, 2492, 2507, 2554, 2599, 2790, 2893, 2943, 2991, 3036, 3144, 3198, 3272, 3326, 3414, 3585, 3619, 4132, 4173], 'Scholar).': [501, 616, 654, 741, 883, 953, 1002, 1083, 1148, 1336, 1392, 1476, 1548, 1836, 2341, 2508, 3037, 3145, 3273, 3327, 3415, 4133, 4174], 'polymer': [503], 'essential': [505, 1399], 'because': [506, 903, 1024, 1742, 3429, 3755, 4080], 'it': [507], 'supplies': [508], 'mechanical': [512], 'protection': [513], 'against': [514, 1494, 2071, 2264], 'osmotic': [516], 'pressure': [517, 559, 593, 965], 'cytoplasm.': [520], 'subunit': [523, 620], 'contains': [524], 'β-1,4-linked': [525], 'N-acetylglucosamine': [526], '(GlcNAc)': [527], '2The': [528, 562], 'abbreviations': [529, 563], 'are:': [531, 565], 'GlcNAc,': [532, 566], 'N-acetylglucosamine;': [533, 567], 'PBP,': [534, 568], 'protein;': [536, 570], 'd-iAsn,': [537, 571], 'd-iso-asparagine;': [538, 572], 'd-iAsp,': [539, 573, 3488], 'd-iso-aspartic': [540, 574], 'acid;': [541, 544, 554, 575, 578, 588], 'mesoDAP,': [542, 576], 'MS,': [545, 579], 'mass': [546, 550, 580, 584, 2559, 2706, 3770, 3776, 3791, 4038], 'spectrometry;': [547, 551, 581, 585], 'MS/MS,': [548, 582, 2857], 'tandem': [549, 583, 2705, 3775], 'MurNAc,': [552, 586], 'N-acetylmuramic': [553, 587, 597], 'RP-HPLC,': [555, 589, 3159], 'reverse': [556, 590], 'phase': [557, 591], 'liquid': [560, 594], 'chromatography.': [561, 595], '(MurNAc)': [599], 'substituted': [600, 2306, 2347, 4030], 'peptide': [603, 697, 1169, 1246, 3800], '(Fig.': [605, 698, 1188, 1294, 1700, 1705, 3237, 3438, 3475, 3953, 4035, 4064], '1A)': [606, 3238], '(2van': [607, 645], 'Heijenoort': [608, 646, 940, 1042, 1220, 1367, 2401, 2587, 2931, 2967, 3018, 3254, 3302, 3396, 3561], 'J.': [609, 647, 824, 922, 941, 1043, 1068, 1114, 1133, 1221, 1224, 1325, 1368, 1377, 1429, 1502, 1529, 1804, 1814, 1821, 1859, 1894, 1904, 1911, 1954, 2187, 2332, 2364, 2402, 2405, 2478, 2540, 2588, 2593, 2776, 2862, 2872, 2879, 2932, 2935, 2968, 2977, 3019, 3022, 3130, 3184, 3255, 3258, 3303, 3312, 3386, 3397, 3400, 3562, 3571, 3605, 4118, 4159], 'Glycobiology.': [610, 648], '2001;': [611, 649, 2937], '11:': [612, 650], '25R-36RCrossref': [613, 651], 'Assembly': [617], 'surface': [624], 'performed': [626, 2811, 3067, 4041, 4068], 'glycosyltransferases': [628], 'polymerize': [630], 'glycan': [632, 643], 'strands': [633, 644], 'formation': [635, 704, 2602, 3469, 3967, 4012, 4060], 'β-1,4': [637], 'bonds': [638], 'd,d-transpeptidases': [640, 3844], 'latter': [656], 'reaction': [657, 702, 2658, 2729, 3365, 3961, 4006], 'catalyzed': [659, 3217, 3369, 3467, 3516, 4011], '(PBPs)': [663], 'cleave': [665], 'd-Ala4-d-Ala5': [667, 787], 'donor': [671, 727, 892, 1173, 1645, 2838, 3508, 3521, 3982, 4020, 4053, 4194, 4209, 4247], 'link': [675], 'carbonyl': [677, 722], 'd-Ala4': [679, 724, 3832], 'amino': [682, 1280, 2570, 3942, 4081], 'group': [683], 'carried': [688], 'residue': [692, 1093, 2310, 3474, 3838], 'an': [694, 1011, 1098, 1162, 1982, 2083, 2132, 2349, 2831, 3073, 3340, 4055], 'acceptor': [695, 1187, 1647, 3523, 3805, 3985, 4018, 4056, 4214, 4245], '1B).': [699, 1189], 'This': [700, 1190, 1728, 4134], 'two-step': [701], 'involves': [703], 'covalent': [707], 'adduct': [708], 'between': [709], 'β-hydroxyl': [711], 'serine': [716], 'PBPs': [719, 1027, 1150, 1204, 1407, 1615, 1744, 3378, 3514, 3540], '(3Jamin': [729], 'M.': [730, 985, 1063, 1132, 1216, 1359, 1500, 1806, 1820, 1896, 1910, 1952, 2404, 2477, 2539, 2775, 2864, 2878, 2923, 2934, 2959, 3014, 3129, 3183, 3257, 3294, 3384, 3394, 3553, 3604, 4117, 4158], 'Wilkin': [731], 'J.M.': [732], 'Frère': [733], 'J.-M.': [734], 'Essays': [735], 'Biochem.': [736, 2500], '1995;': [737, 1966], '29:': [738], '1-24PubMed': [739], 'glycosyltransferase': [743], 'activities': [746], 'multimodular': [749], 'polymerases': [751], 'are': [752, 783, 847, 1300, 1482, 1745, 3993], 'targets': [754, 1486], 'two': [757, 3222, 3234], 'major': [758, 3450], 'classes': [759], 'antibiotics': [761, 1492], 'available': [762], 'treat': [764], 'severe': [765], 'infections': [766], 'due': [767], 'bacteria,': [770, 1410], 'β-lactams': [772, 782, 1017], 'glycopeptides,': [775], 'act': [777, 789], 'different': [779, 1726, 3897, 3991], 'mechanisms.': [780], 'structural': [784, 1690], 'analogues': [785], 'as': [790, 1199, 1318, 1341, 1484, 1800, 2140, 2151, 2299, 2302, 2715, 2723, 2754, 2806, 2835, 2858, 3463, 3980, 4051], 'suicide': [791], 'substrates': [792, 1579, 2300, 2724, 3902, 4248], 'module': [796], 'PBPs.': [799], 'glycopeptides': [801, 902, 967, 1602], 'bind': [802], 'peptidyl-d-Ala4-d-Ala5': [805], 'extremity': [806], 'block': [811], 'steric': [813], 'hindrance': [814], 'both': [815, 1249], 'transglycosylation': [817], 'transpeptidation': [819], 'reactions': [820, 2851], '(4Reynolds': [821, 919], 'P.E.': [822, 920], 'Eur.': [823, 921], 'Clin.': [825, 923], 'Infect.': [827, 925], 'Dis.': [828, 926], '1989;': [829, 927], '8:': [830, 928], '943-950Crossref': [831, 929], 'Scopus': [833, 931, 999, 1080, 1145, 1236, 1389, 1435, 1450, 1473, 1512, 1545, 1833, 1923, 1970, 2205, 2338, 2417, 2490, 2505, 2552, 2788, 2891, 2941, 2989, 3034, 3142, 3196, 3270, 3324, 3412, 3583, 3617, 4130, 4171], '(529)': [834, 932], 'Scholar).The': [836, 2791], 'pathway': [838], 'mode': [844, 1191, 2684], 'polymerization': [846], 'generally': [848, 1746], 'conserved': [850], 'eubacteria.': [852], 'Variations': [853], 'involve': [860], 'fifth': [863, 979], '(C-terminal)': [864], 'positions': [867, 1648], '(5Schleifer': [872, 1282], 'K.H.': [873, 1283], 'Kandler': [874, 1284], 'O.': [875, 1285], 'Bacteriol.': [876, 1286, 1430, 1860, 2333, 2365, 2594, 2936], '1972;': [878, 1288], '36:': [879, 1289], '407-477Crossref': [880, 1290], 'bottleneck': [895], 'limits': [897], 'emergence': [898], 'modifications': [905, 955], 'prevent': [910], 'drug': [911, 1590], 'binding': [912], 'should': [913], 'these': [917, 1159, 3956], 'Scholar,': [934, 1055, 1438, 1515, 3586], '6al-Obeid': [935], 'S.': [936, 1038, 1357, 1440, 1964, 2957, 3292, 3545, 3551], 'Billot-Klein': [937, 1039], 'D.': [938, 1040, 1519, 2397, 2399, 2473, 2535, 2581, 2585, 2771, 2921, 2929, 3125, 3179, 3250, 3252, 3388, 3600, 4113, 4154], 'van': [939, 1041, 1219, 1366, 2586, 2930, 2966, 3017, 3301, 3560], 'Collatz': [942, 1044], 'Gutmann': [944, 1046, 1127, 1222, 1364, 1817, 1907, 2324, 2875, 2924, 2964, 3020, 3299, 3398, 3558], 'L.': [945, 1047, 1122, 1128, 1223, 1361, 1365, 1374, 1810, 1818, 1900, 1908, 2325, 2469, 2531, 2767, 2868, 2876, 2925, 2961, 2965, 2974, 3021, 3121, 3175, 3296, 3300, 3309, 3399, 3555, 3559, 3568, 3596, 4109, 4150], 'FEMS': [946, 1048], 'Lett.': [948, 1050], '1992;': [949, 1051], '70:': [950, 1052], '79-84PubMed': [951, 1053], 'Successful': [954], 'have': [957, 1010, 2454], 'spread': [958], 'pathogens': [961, 1496], 'under': [962, 2947, 3151, 3336], 'selective': [964], 'include': [968], 'incorporation': [969, 3676], 'd-lactate': [971], 'or': [972, 1262, 1269, 2630, 2647, 2844, 3048, 3491, 3848, 4054], 'd-Ser': [973], 'd-Ala': [976], 'stems': [983, 1096], '(7Arthur': [984], 'Reynolds': [986], 'P.': [987, 989, 1958, 2323], 'Courvalin': [988], 'Trends': [990], '1996;': [992, 1508], '4:': [993], '401-407Abstract': [994], 'Full': [995, 1074, 1076, 1139, 1141, 1230, 1232, 1331, 1383, 1385, 1539, 1541, 1827, 1829, 1917, 1919, 2411, 2413, 2484, 2486, 2546, 2548, 2782, 2784, 2885, 2887, 2983, 2985, 3028, 3030, 3136, 3138, 3190, 3192, 3264, 3266, 3318, 3320, 3406, 3408, 3577, 3579, 3611, 3613, 4124, 4126, 4165, 4167], 'Text': [996, 1075, 1077, 1140, 1142, 1231, 1233, 1332, 1384, 1386, 1540, 1542, 1828, 1830, 1918, 1920, 2412, 2414, 2485, 2487, 2547, 2549, 2783, 2785, 2886, 2888, 2984, 2986, 3029, 3031, 3137, 3139, 3191, 3193, 3265, 3267, 3319, 3321, 3407, 3409, 3578, 3580, 3612, 3614, 4125, 4127, 4166, 4168], 'PDF': [997, 1078, 1143, 1234, 1333, 1387, 1543, 1831, 1921, 2415, 2488, 2550, 2786, 2889, 2987, 3032, 3140, 3194, 3268, 3322, 3410, 3581, 3615, 4128, 4169], '(314)': [1000], 'Strikingly,': [1003], 'production': [1004], 'd-lactate-ending': [1006], 'can': [1008, 1762, 3367, 3962], 'impact': [1012], 'on': [1013, 1619, 2056, 2109, 2259, 4069], 'enterococci': [1020, 2459], 'staphylococci,': [1022], 'presumably': [1023], 'low': [1025, 1405, 3758, 3828], 'affinity': [1026, 1406, 2054, 2257], 'responsible': [1028], 'cannot': [1032, 1151], 'function': [1033, 1152], 'modified': [1035, 1635, 3520], '(6al-Obeid': [1037], '8Severin': [1056], 'A.': [1057, 1067, 1126, 1525, 1965, 2195, 2387, 2391, 2461, 2523, 2759, 2917, 3113, 3167, 3240, 3244, 3588, 4101, 4142], 'Tabei': [1058, 2392, 3245], 'K.': [1059, 1424, 1523, 2393, 3246], 'Tenover': [1060], 'F.': [1061], 'Chung': [1062], 'Clarke': [1064], 'N.': [1065, 1118, 2389, 2467, 2529, 2765, 2919, 3119, 3173, 3242, 3594, 4107, 4148], 'Tomasz': [1066], 'Chem.': [1070, 1135, 1226, 1327, 1379, 1823, 1913, 2407, 2480, 2542, 2778, 2881, 2979, 3024, 3132, 3186, 3260, 3314, 3402, 3573, 3607, 4120, 4161], '2004;': [1071, 2481, 2543, 2779, 3133, 3187, 3608, 4121, 4162], '279:': [1072, 2482, 2544, 2780, 3134, 3188, 3609, 4122, 4163], '3398-3407Abstract': [1073], '(87)': [1081], 'Total': [1084], 'elimination': [1085], 'd-Ala5': [1087], 'hydrolysis': [1089, 2575], 'C-terminal': [1092, 3831], 'alternative': [1099], 'mechanism': [1100], 'mutants': [1105, 1160], 'faecium': [1108, 1631, 1781, 2625, 2904, 3007, 3351, 3427, 3625, 3639, 3947], 'selected': [1109], 'laboratory': [1111], 'conditions': [1112, 2241, 3153], '(9Cremniter': [1113], 'Mainardi': [1115, 1375, 2330, 2926, 2975, 3310, 3569], 'J.L.': [1116, 1324, 1376, 2331, 2976, 3311, 3380, 3570], 'Josseaume': [1117, 2388, 2466, 2528, 2764, 2918, 3118, 3172, 3241, 3593, 4106, 4147], 'Quincampoix': [1119], 'J.C.': [1120], 'Dubost': [1121, 1360, 1809, 1899, 2468, 2530, 2766, 2867, 2960, 3120, 3174, 3295, 3554, 3595, 4108, 4149], 'Hugonnet': [1123, 1362, 1807, 1897, 2394, 2462, 2524, 2760, 2865, 2962, 3114, 3168, 3247, 3297, 3556, 3589, 4102, 4143], 'J.E.': [1124, 1363, 1808, 1898, 2395, 2463, 2525, 2761, 2866, 2963, 3115, 3169, 3248, 3298, 3557, 3590, 4103, 4144], 'Marie': [1125], 'Rice': [1129, 1373, 1815, 1905, 2873, 2973, 3308, 3567], 'L.B.': [1130, 1816, 1906, 2874], 'Arthur': [1131, 1215, 1358, 1819, 1909, 2403, 2476, 2538, 2774, 2877, 2933, 2958, 3013, 3128, 3182, 3256, 3293, 3393, 3552, 3603, 4116, 4157], '2006;': [1136, 1380, 2980, 3315, 3574], '281:': [1137, 1381, 2981, 3316, 3575], '32254-32262Abstract': [1138], '(30)': [1146], 'Because': [1149], 'donors,': [1155], 'requires': [1161], 'l,d-transpeptidase': [1163, 1760, 1849, 2176, 2246, 2620, 2792], '(Ldtfm)': [1164], 'cleaves': [1166], 'links': [1175], 'carboxyl': [1177], 'l-Lys3': [1179], 'amine': [1184], 'been': [1196, 1582, 2455, 4049], 'originally': [1197], 'identified': [1198, 2557, 2853], 'confers': [1206], '(10Mainardi': [1211, 3009], 'J.-L.': [1212, 2927, 3010], 'Legrand': [1213, 1369, 2326, 2969, 3011, 3304, 3389, 3563], 'R.': [1214, 1322, 1370, 1466, 1527, 1533, 2327, 2970, 3012, 3305, 3390, 3564], 'Schoot': [1217, 2328, 3015], 'B.': [1218, 1428, 1442, 1713, 1950, 2178, 2329, 2498, 2631, 3016, 3929], '2000;': [1227, 2334, 3025], '275:': [1228, 3026], '16490-16496Abstract': [1229, 3027], '(112)': [1237, 3035], 'Scholar).Variation': [1239], 'concerns': [1248], 'nature': [1251], 'diamino': [1254], 'present': [1256], 'position,': [1259], 'e.g.': [1260], 'l-Lys': [1261], '(mesoDAP),': [1265], 'presence': [1268, 3646, 3932, 4204], 'absence': [1270, 3922, 4092, 4229], 'comprising': [1275], 'one': [1277, 2254], 'five': [1279], 'acids': [1281, 1299, 3943], 'Scholar)': [1293, 1453, 1926, 2371, 2493, 2555, 2944, 2992], '1A).': [1295, 1701, 3954], 'Glycine': [1296], 'l-amino': [1298], 'incorporated': [1301], 'into': [1302, 1887, 2228, 3005, 3349, 3679, 4139], 'transferases': [1310, 1481], 'Fem': [1313, 1480, 1554, 1624, 3226, 3673], 'use': [1316, 1566], 'aminoacyl-tRNAs': [1317], '(11Plapp': [1321], 'Strominger': [1323], '1970;': [1328], '245:': [1329], '3667-3674Abstract': [1330], 'd-Aspartic': [1337], 'activated': [1340], 'β-aspartyl-phosphate': [1342], 'ligated': [1344], 'ATP-dependent': [1349], 'ligases': [1350], 'belonging': [1351], 'ATP-Grasp': [1354], 'superfamily': [1355], '(12Bellais': [1356, 2956, 3291, 3550], 'Brouard': [1371, 1811, 1901, 2474, 2536, 2772, 2869, 2971, 3126, 3180, 3306, 3565, 3601, 4114, 4155], 'J.P.': [1372, 1812, 1902, 2475, 2537, 2773, 2870, 2972, 3127, 3181, 3307, 3566, 3602, 4115, 4156], '11586-11594Abstract': [1382, 2982, 3317, 3576], '(70)': [1390, 2990, 3325, 3584], 'Synthesis': [1393], 'complete': [1395], 'chains': [1397, 3447], 'mediated': [1403, 1415], 'particular': [1412], 'methicillin': [1413], 'PBP2a': [1417], 'Staphylococcus': [1419], 'aureus': [1420, 3546], '(13Stranden': [1421], 'A.M.': [1422], 'Ehlert': [1423], 'Labischinski': [1425, 1503], 'H.': [1426, 1504], 'Berger-Bachi': [1427, 1441], '1997;': [1431], '179:': [1432], '9-16Crossref': [1433], '(164)': [1436], '14Rohrer': [1439], 'Antimicrob.': [1443], 'Agents': [1444], 'Chemother.': [1445], '2003;': [1446], '47:': [1447], '837-846Crossref': [1448], '(89)': [1451], 'penicillin': [1455], 'resistance-mediated': [1456], 'PBP2X': [1457], 'Streptococcus': [1459], 'pneumoniae': [1460], '(15Laible': [1461], 'G.': [1462, 1531], 'Spratt': [1463], 'B.G.': [1464], 'Hakenbeck': [1465], '1991;': [1469], '5:': [1470], '1993-2002Crossref': [1471], '(212)': [1474], 'For': [1477], 'reason,': [1479], 'considered': [1483], 'attractive': [1485], 'development': [1489, 1591], 'novel': [1491], 'β-lactam-resistant': [1495], '(16Kopp': [1497], 'U.': [1498, 1963, 2191], 'Roos': [1499], 'Wecke': [1501], 'Microb.': [1505], 'Drug': [1506], 'Resist.': [1507], '2:': [1509], '29-41Crossref': [1510], '(77)': [1513], '17Benson': [1516], 'T.': [1517, 2583], 'Prince': [1518], 'Mutchler': [1520], 'V.': [1521, 3382], 'Curry': [1522], 'Ho': [1524], 'Sarver': [1526], 'Hagadorn': [1528], 'Choi': [1530], 'Garlick': [1532], 'Structure': [1534], '(Camb).': [1535], '2002;': [1536, 2408, 3261, 3403], '10:': [1537], '1107-1115Abstract': [1538], '(64)': [1546], 'antibacterial': [1550], 'such': [1553], 'inhibitors': [1555], 'will': [1556], 'ultimately': [1557], 'depend': [1558], 'upon': [1559], 'incapacity': [1561], 'incomplete': [1569], 'chains.Interaction': [1571], 'not': [1581, 2726, 3749, 4211], 'extensively': [1583], 'investigated,': [1584], 'despite': [1585], 'pivotal': [1587], 'role': [1588], 'our': [1594], 'understanding': [1595], 'mechanisms': [1598], 'β-lactams.': [1604], 'report,': [1607], 'compared': [1617], 'based': [1618], 'heterospecific': [1620], 'expression': [1621], 'transferase': [1625, 3418, 3670], 'search': [1633], 'peptides': [1637, 1699, 4022, 4029], 'l-Lys3-l-Ala': [1639], 'dimers': [1650, 2605, 2698, 2710, 3451, 3482, 3782, 3808, 4086], 'generated': [1651, 2699, 2712, 3452, 3483, 3497, 3842, 3854], 'vivo': [1653, 4241], 'l,d-transpeptidation': [1655, 3485, 3856], 'd,d-transpeptidation.': [1657, 3499], 'studied': [1664], 'vitro': [1666, 2601, 2701, 2714, 4226], 'directly': [1668], 'testing': [1669], 'fragments': [1674], 'isolated': [1675], 'species': [1679], '(E.': [1680], 'subtilis,': [1683], 'faecalis)': [1686, 3952], 'representative': [1687, 3904], 'variability': [1691], 'Finally,': [1702], '1C)': [1706], 'purified': [1708, 1791, 2047, 2104, 2252, 2313, 2355, 2429], 'compare': [1716], 'bacteria': [1722, 1975, 3094, 3919], 'producing': [1723, 3627], 'chemotypes.': [1727], 'analysis': [1729, 2572], 'represents': [1730], 'inactive': [1747], 'vitro.': [1749], 'addition,': [1751], 'characterization': [1752], 'revealed': [1755], 'members': [1757, 3223], 'display': [1764], 'l,d-carboxypeptidase': [1765], 'l,d-endopeptidase': [1767], 'activities.EXPERIMENTAL': [1768], 'PROCEDURESProduction': [1769], 'Purification': [1771], 'l,d-Transpeptidases—A': [1773], 'catalytically': [1774], 'fragment': [1776, 1838], 'M512': [1782, 2905, 3008, 3352, 3626], '(residues': [1783], '119–466)': [1784], 'produced': [1786, 2233], 'coli': [1789, 1943, 2236, 2432, 2496], 'affinity,': [1793], 'anion': [1794, 2084], 'exchange,': [1795], 'size': [1797, 2106], 'exclusion': [1798, 2107], 'chromatographies,': [1799], 'described': [1802, 2242, 2457, 2716, 2860], '(18Mainardi': [1803, 1893, 2861], 'Fourgeaud': [1805, 1895, 2863, 3383], 'Ouazzani': [1813, 1903, 2871], '2005;': [1824, 1914, 2202, 2882], '280:': [1825, 1915, 2883], '38146-38152Abstract': [1826, 1916, 2884], '(155)': [1834, 1924, 2892], 'A': [1837], 'open': [1841, 2171], 'reading': [1842, 2172], 'frame': [1843, 2173], 'encoding': [1844, 2174, 3668], 'residues': [1845, 3236], '136–474': [1846], 'strain': [1853, 2180, 2320, 2377, 2433, 3040], 'JH2-2': [1854, 2359, 2378], '(19Jacob': [1855, 2360], 'A.E.': [1856, 2361], 'Hobbs': [1857, 2362], 'S.J.': [1858, 2363], '1974;': [1861, 2366], '117:': [1862, 2367], '360-372Crossref': [1863, 2368], 'Scholar),': [1866, 1973, 2208, 2420], 'amplified': [1869, 2210], 'primers': [1871, 2212], '5′-AACCATGGGGAGTATCCGTCGAGGCAATGG-3′': [1872], '5′-AAGGATCCTACTTCTTCGCCGTAATCTA-3′.': [1874], 'PCR': [1876, 2218], 'product': [1877, 2219], 'digested': [1879, 2220, 3106], 'NcoI': [1881, 2222], 'BamHI': [1883, 2224], '(underlined)': [1884, 2225], 'cloned': [1886, 2227, 3335], 'pET2818,': [1888, 2229], 'derivative': [1890, 2375], 'pET2816': [1892], 'lacking': [1927], 'sequence': [1929, 2693], 'specifying': [1930], 'thrombin': [1932], 'cleavage': [1933, 4073], 'site.': [1934], 'resulting': [1936, 2050, 2510, 2745, 2998, 3147, 3698], 'plasmid,': [1937, 2999], 'pET2818Ωldtfs,': [1938], 'introduced': [1940, 3002, 3348], 'BL21(DE3)': [1944], 'harboring': [1945, 2379], 'pREP4GroESL': [1946], '(20Amrein': [1947], 'K.E.': [1948], 'Takacs': [1949], 'Stieger': [1951], 'Molnos': [1953], 'Flint': [1955], 'N.A.': [1956], 'Burn': [1957], 'Proc.': [1959], 'Natl.': [1960], 'Acad.': [1961], 'Sci.': [1962], '92:': [1967], '1048-1052Crossref': [1968], '(150)': [1971], 'grown': [1977, 3042, 3643], '37': [1979, 3085], '°C': [1980, 2160, 2278, 3086], 'optical': [1983, 3074, 3089], 'density': [1984, 3075, 3090], '600': [1986, 3077], 'nm': [1987, 3078], '0.8': [1989], 'brain': [1991, 3044], 'heart': [1992, 3045], 'infusion': [1993, 3046], 'broth': [1994, 3047], '(Difco,': [1995], 'Elancourt,': [1996], 'France)': [1997], 'ampicillin': [1999], '(100': [2000], 'μg/ml).': [2001], 'Isopropyl-β-d-thiogalactopyranoside': [2002], 'added': [2004, 3279], 'final': [2007], 'concentration': [2008, 2563], '0.5': [2010], 'mm,': [2011, 2615], 'incubation': [2013], 'continued': [2015, 3083], '17': [2017], 'h': [2018, 2663], '16': [2020], '°C.': [2021], 'cells': [2023], 'disrupted': [2025], 'sonication': [2027], '50': [2029, 2072, 2118, 2162, 2265], 'mm': [2030, 2036, 2067, 2073, 2079, 2100, 2119, 2125, 2163, 2169, 2266, 2272, 2817, 3070], 'Tris-HCl,': [2031, 2074, 2120, 2164, 2267], 'pH': [2032, 2075, 2121, 2165, 2268, 2616, 2821], '7.5,': [2033, 2122, 2166, 2269], '300': [2035, 2124, 2168], 'NaCl,': [2037, 2080, 2101, 2273], 'debris': [2040], 'removed': [2042], 'centrifugation.': [2044, 3098], 'clarified': [2051], 'lysate': [2052], 'chromatography': [2055, 2108, 2258], 'Ni2+-nitrilotriacetate-agarose': [2057, 2260], 'resin': [2058, 2261], '(Qiagen': [2059], 'GmbH,': [2060], 'Hilden,': [2061], 'Germany).': [2062], 'Proteins': [2063, 2198], 'eluted': [2064], '200': [2066], 'imidazole': [2068], 'dialyzed': [2070, 2263], '8.0,': [2076], '60': [2078], 'loaded': [2081], 'onto': [2082], 'exchange': [2085], 'column': [2086, 2113, 2670, 2740], '(MonoQ': [2087], 'HR5/5,': [2088], 'Amersham': [2089], 'Biosciences)': [2090, 2115], 'equilibrated': [2091, 2116], 'same': [2094, 2281, 3976], 'buffer.': [2095, 2282], 'eluting': [2097], '∼300': [2099], 'further': [2103], 'Superdex': [2111], 'HR10/30': [2112], '(Amersham': [2114], 'NaCl.': [2126], 'protein': [2128, 2145, 2155, 2286], 'obtained': [2130, 2288, 3890, 4071], 'overall': [2133], 'yield': [2134], '3': [2136], 'mg/liter': [2137], 'culture,': [2139], 'estimated': [2141, 2568], 'Bio-Rad': [2144], 'assay': [2146, 2810], 'using': [2147, 2238, 2667, 2737, 2752, 2800, 2993, 3470], 'bovine': [2148], 'serum': [2149], 'albumin': [2150], 'standard.': [2153], 'stored': [2157, 2275], '–80': [2159], 'NaCl.The': [2170], '168,': [2181], 'LdtBs,': [2182], 'named': [2184], 'ykuD': [2185], '(21Bielnicki': [2186], 'Devedjiev': [2188], 'Y.': [2189], 'Derewenda': [2190, 2196], 'Dauter': [2192], 'Z.': [2193, 2197], 'Joachimiak': [2194], 'Struct.': [2199], 'Funct.': [2200], 'Genet.': [2201], '144-151Crossref': [2204], '(78)': [2206], '5′-AACCATGGGGCTGCTTACGTACCAGGTGAAGC-3′': [2213], '5': [2215, 3727], '′-TTGGATCCCCGGTTAATCGTGACTCTCGT-3′.': [2216], 'BL21(DE3)/pREP4GroESL': [2237], 'inducing': [2240], 'above': [2243, 2717], 'faecalis.': [2249, 3631], 'step': [2255], '(Qiagen),': [2262], '100': [2271], '–20': [2277], '10': [2283, 2609, 2813], 'mg': [2284], 'per': [2289], 'liter': [2290], 'culture.l,d-Transpeptidase': [2292], 'Assays—The': [2293], 'source': [2294], 'disaccharide-peptides': [2297, 2721, 3992, 4076], 'follows.': [2303], 'disaccharide-tetrapeptide': [2305, 2346, 2423, 2829], 'd-iso-asparagine': [2309], '(l-Lys3-d-iAsn)': [2311], 'gallinarum': [2319], 'SC1': [2321], '(22Grohs': [2322], '182:': [2335], '6228-6232Crossref': [2336], '(32)': [2339], 'disaccharide-pentapeptide': [2343], 'l-Ala-l-Ala': [2350, 2803, 2832, 4032, 4186], '(l-Lys3-l-Ala-l-Ala)': [2353], 'vanA': [2381], 'gene': [2384, 2912, 3065, 3330, 3667], 'cluster': [2385], '(23Bouhss': [2386, 3239], 'Severin': [2390, 3243], 'Shlaes': [2396, 3249], 'Mengin-Lecreulx': [2398, 2928, 3251], 'Van': [2400, 3253, 3395], '277:': [2409, 3262, 3404], '45935-45941Abstract': [2410, 3263], '(61)': [2418, 3271], 'respectively.': [2421], 'ATCC': [2434], '25113.': [2435], 'procedures': [2437], 'preparation,': [2441], 'digestion': [2442, 3892], 'muramidases,': [2444], 'reduction': [2446], 'MurNAc': [2448], 'muramitol': [2450], 'sodium': [2452], 'borohydride': [2453], '(24Arbeloa': [2460, 2522, 2758, 3112, 3166, 4100, 4141], 'Sentilhes': [2464, 2526, 2762, 3116, 3170, 3591, 4104, 4145], 'A.C.': [2465, 2527, 2763, 3117, 3171, 3592, 4105, 4146], 'Monsempes': [2470, 2532, 2768, 3122, 3176, 3597, 4110, 4151], 'C.': [2471, 2533, 2769, 3123, 3177, 3392, 3598, 4111, 4152], 'Blanot': [2472, 2534, 2584, 2770, 3124, 3178, 3387, 3599, 4112, 4153], '41546-41556Abstract': [2483, 2545, 2781, 3135, 3189, 3610, 4123, 4164], '(57)': [2491, 2553, 2789, 3143, 3197, 3618, 4131, 4172], '(25Glauner': [2497], 'Anal.': [2499], '1988;': [2501], '172:': [2502], '451-464Crossref': [2503], '(347)': [2506], 'muropeptides': [2511, 2566, 3148, 3636, 3746, 3826], 'separated': [2513, 3157, 3701], 'RP-HPLC': [2515, 3633], 'acetonitrile': [2517], 'gradients': [2518], 'trifluoroacetic': [2520], 'spectrometry': [2560, 2707, 3777, 4002, 4039], '(MS).': [2561], 'after': [2573], 'acidic': [2574], 'Hitachi': [2578], 'autoanalyzer': [2579], '(26Mengin-Lecreulx': [2580], 'Falla': [2582], 'Adams': [2589], 'D.J.': [2590], 'Chopra': [2591], 'I.': [2592], '1999;': [2595], '181:': [2596], '5909-5914Crossref': [2597], 'Scholar).In': [2600], 'muropeptide': [2604], 'tested': [2607, 2798], 'μl': [2610, 2814], 'phosphate': [2612, 2819], 'buffer': [2613], '(20': [2614], '7.0)': [2617], '(7': [2621, 2825], 'μm)': [2622], '(Ldtfm),': [2626], '(Ldtfs),': [2629], 'combination': [2636], 'reduced': [2639], 'disaccharide-tetrapeptides': [2640, 3889], '(200': [2641, 2839], 'μm': [2642], 'each)': [2643], 'l-Lys3-d-iAsn,': [2645], 'l-Lys3-l-Ala-l-Ala,': [2646], 'stem.': [2656], 'incubated': [2660], '2': [2662], '37°C,': [2665], 'desalted': [2666, 2736], 'micro': [2669, 2739], '(ZipTipC18;': [2671], 'Millipore,': [2672], 'Saint': [2673], 'Quentin-en-Yvelines,': [2674], 'France),': [2675], 'analyzed': [2677, 2748, 3161, 3882], 'nanoelectrospray': [2679, 2750], 'MS': [2680, 2855, 3163], 'positive': [2683], '(Qstar': [2685], 'Pulsar': [2686], 'I;': [2687], 'Applied': [2688], 'Biosystem,': [2689], 'Courtaboeuf,': [2690], 'France).': [2691], 'cross-links': [2696, 3480, 3496], 'determined': [2703], '(MS/MS).': [2708], 'Briefly,': [2709], 'except': [2718], 'reduced.': [2727], 'mixture': [2730], 'treated': [2732, 3692], 'ammonium': [2734, 3694], 'hydroxide,': [2735, 3695], '(ZipTipC18,': [2741], 'Millipore),': [2742], 'lactoyl-peptides': [2746, 3699, 3763, 4070], 'MS/MS': [2751, 3165], 'N2': [2753], 'collision': [2756], 'gas': [2757], 'dipeptides': [2802], 'd-Ala-d-Ala': [2805, 2845], 'acceptors.': [2808], '20': [2816], 'potassium': [2818], 'buffer,': [2820], '7.0,': [2822], 'contained': [2823, 3433, 3458, 3487, 3846, 3859], 'μm),': [2826, 2840], '1': [2842, 3441, 3725], 'mml-Ala-l-Ala': [2843], '(Sigma).': [2846], 'products': [2848, 4007], 'Scholar).Expression': [2894], 'bppA1': [2897, 2911, 3064, 3329, 3666], 'Gene': [2898], 'Analysis': [2907], 'Peptidoglycan': [2909, 3099, 3686], 'Structure—The': [2910], 'plasmid': [2914, 3345, 3656], 'pDA15': [2915], '(27Bouhss': [2916], 'Allanic': [2920], 'Crouvoisier': [2922], '183:': [2938], '5122-5127Crossref': [2939], '(35)': [2942], 'subcloned': [2946], 'control': [2949, 3338], 'inducible': [2952, 3341], 'promoter': [2953, 3342], 'pJEH4': [2955], 'XbaI': [2994], 'KpnI.': [2996], 'pJEH6(bppA1),': [3000], 'electroporation': [3004], 'recombinant': [3039], 'agar': [3049], '(Difco)': [3050], 'spectinomycin': [3052, 3648], '(120': [3053, 3649], 'μg/ml)': [3054, 3650], 'counter': [3056, 3652], 'select': [3057, 3653], 'loss': [3058, 3654], 'pJEH6(bppA1).': [3060], 'Induction': [3061], '0.3': [3069], 'isopropyl-β-d-thiogalactopyranoside': [3071, 3660], '0.02.': [3080], 'Incubation': [3081], 'until': [3087], 'reached': [3091], '0.6,': [3092], 'collected': [3096], 'extracted': [3101, 3688], 'boiling': [3103], 'SDS': [3104, 3690], 'mutanolysin': [3108], 'lysozyme': [3110], '(Sigma-Aldrich)': [3111], 'cleaved': [3150], 'alkaline': [3152, 4078], 'generate': [3155, 3344], 'lactoyl-peptides,': [3156], 'Scholar).RESULTS': [3199], 'AND': [3200], 'DISCUSSIONProbing': [3201], 'Substrate': [3203], 'Specificity': [3204], 'Vivo—Synthesis': [3208], 'family,': [3227], 'BppA1': [3228, 3417, 3628], 'BppA2,': [3230], 'sequentially': [3232], 'add': [3233], 'l-Ala': [3235, 3434, 3492, 3678, 3849, 4206], 'd-Asp': [3277], 'Aslfm': [3285, 3423], 'ligase': [3286, 3424], 'subsequently': [3288], 'partially': [3289], 'amidated': [3290], 'pJEH6': [3346], 'order': [3354], 'manipulate': [3356], 'mutant': [3372], '(28Mainardi': [3379], 'Morel': [3381], 'Cremniter': [3385], 'Frehel': [3391], '35801-35807Abstract': [3405], '(65)': [3413], 'efficiently': [3419], 'competed': [3420], 'M512/pJEH6(bppA1)': [3428], 'main': [3431, 3907], 'monomers': [3432, 3780, 3802], 'd-iAsp': [3437, 3490, 3847, 3860, 4140, 4197], '2,': [3439, 3476], 'peaks': [3440, 3477, 3724, 3754], '2).': [3443], 'free': [3445, 4189], 'l,d-': [3454], 'd,d-transpeptidation': [3456], 'l-Ala,': [3459], 'indicating': [3460], 'Ldtfm,': [3462], 'PBPs,': [3465], 'had': [3466, 4048], 'donors': [3471], '3–5).': [3478], 'exclusively': [3486, 3858], 'whereas': [3489], 'only': [3505], 'substrate,': [3509, 3986], 'substrates.': [3524], 'Modifications': [3525], 'previous': [3548], 'studies': [3549], '24Arbeloa': [3587], 'Scholar).FIGURE': [3620], '2Peptidoglycan': [3621], 'composition': [3622], 'A,': [3632], 'profile': [3634], 'M512/pJEH6(bppA1).': [3640], 'Bacteria': [3641], 'pJEH6(bppA1)': [3657], '(0.3': [3661], 'mm)': [3662], 'induce': [3664], 'precursors.': [3685], 'RP-HPLC.': [3703], 'mAU,': [3704], 'absorbance': [3705, 3734], 'unit': [3706], '×': [3707], '103': [3708], '210': [3710, 3736], 'nm.': [3711, 3737], 'B,': [3712], 'muropeptides.': [3715], 'relative': [3717], 'abundance': [3718], '(%)': [3719], 'material': [3722], 'calculated': [3729, 3790], 'integration': [3731], 'retention': [3739], 'time': [3740], '(RT)': [3741], 'indicated': [3743, 4008], 'minor': [3745], 'assigned': [3751], 'abundance.': [3759], 'deduced': [3765], 'observed': [3768, 3788, 4224], 'monoisotopic': [3769], '(Mass)': [3771], 'confirmed': [3773], 'most': [3779], '(indicated': [3783], 'star).': [3786], 'maximum': [3795], '0.2.': [3797], 'consisted': [3809], 'tripeptide': [3812], 'l-Ala1-d-iGln2-l-Lys3': [3813], '(Tri),': [3814], 'l-Ala1-d-iGln2-l-Lys3-d-Ala4': [3817], '(Tetra),': [3818], 'l-Ala1-d-iGln2-l-Lys3-d-Ala4-d-Ala5': [3822], '(Penta).': [3823], 'certain': [3825], 'abundance,': [3829], 'replaced': [3834], 'glycyl': [3837], '(Gly': [3839], 'C-ter).': [3840], 'Cross-links': [3841, 3853], '(DD)': [3845], '(d-Ala4→d-iAsp-l-Lys3': [3850], 'd-Ala4→l-Ala-l-Lys3).': [3852], '(LD)': [3857], '(l-Lys3→d-iAsp-l-Lys3).View': [3861], 'Large': [3862], 'Image': [3863], 'Figure': [3864], 'ViewerDownload': [3865], 'Hi-res': [3866], 'image': [3867], 'Download': [3868], '(PPT)Ldtfm': [3869], 'Is': [3870], 'Also': [3871], 'Specific': [3872], 'd-iAsn-substituted': [3874, 4017], 'Acceptors': [3875], 'Vitro—The': [3877], 'incubating': [3884], 'enzyme': [3886, 4236], 'chemotypes': [3898], 'muramidases.': [3900], 'variations': [3908], 'including': [3920, 3971], '(mesoDAP3': [3927], 'subtilis)': [3930], 'consisting': [3937], 'd': [3939], 'l': [3941], '(l-Lys3-d-iAsn': [3944], 'With': [3955], 'substrates,': [3958], 'potentially': [3963], 'lead': [3964], 'nine': [3969], 'dimers,': [3970], 'homodimers,': [3973], 'if': [3974, 3990], 'six': [3988], 'heterodimers,': [3989], 'all': [3996], 'possible': [3997], 'combinations': [3998], '(Table': [3999], '1).': [4000], 'Mass': [4001], 'analyses': [4003], 'homodimer': [4015], 'heterodimer': [4026, 4063, 4183], 'd-iAsn': [4034, 4138], '3).': [4036], 'Tandem': [4037], 'determine': [4043], 'whether': [4044], 'l-Ala-l-Ala-substituted': [4046], '4).': [4065], 'Fragmentation': [4066], 'treatment': [4079, 4135], 'sequencing': [4083], 'more': [4088], 'efficient': [4089], 'disaccharide': [4095], 'moiety': [4096], 'molecules': [4099], 'converts': [4137], 'As': [4175], 'detailed': [4176], 'Fig.': [4178], '4,': [4179], 'fragmentation': [4180], 'allowed': [4184], 'assigning': [4185], 'cross-link.': [4200], 'but': [4210], 'any': [4231], 'other': [4232], 'biosynthesis': [4235], 'accounts': [4237], 'selection': [4242], 'th': [4250]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2049189393', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 8}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 8}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 7}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 7}, {'year': 2013, 'cited_by_count': 5}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2024-12-13T03:45:51.014306', 'created_date': '2016-06-24'}