High expression of the chemokine receptor CCR3 in human blood basophils. Role in activation by eotaxin, MCP-4, and other chemokines.

Name: Work Video:
Duration: 3 min 30 s
Mariagrazia Uguccioni; Charles R. Mackay; B Ochensberger; Pius Loetscher; S Rhis; G J LaRosa; Patricia E. Rao; Paul Ponath; Marco Baggiolini; Clemens A. Dahinden
{'id': 'https://openalex.org/W2048988599', 'doi': 'https://doi.org/10.1172/jci119624', 'title': 'High expression of the chemokine receptor CCR3 in human blood basophils. Role in activation by eotaxin, MCP-4, and other chemokines.', 'display_name': 'High expression of the chemokine receptor CCR3 in human blood basophils. Role in activation by eotaxin, MCP-4, and other chemokines.', 'publication_year': 1997, 'publication_date': '1997-09-01', 'ids': {'openalex': 'https://openalex.org/W2048988599', 'doi': 'https://doi.org/10.1172/jci119624', 'mag': '2048988599', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/9276730', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/508288'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1172/jci119624', 'pdf_url': 'http://www.jci.org/articles/view/119624/files/pdf', 'source': {'id': 'https://openalex.org/S114430552', 'display_name': 'Journal of Clinical Investigation', 'issn_l': '0021-9738', 'issn': ['0021-9738', '1558-8238'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320279', 'host_organization_name': 'American Society for Clinical Investigation', 'host_organization_lineage': ['https://openalex.org/P4310320279'], 'host_organization_lineage_names': ['American Society for Clinical Investigation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'http://www.jci.org/articles/view/119624/files/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5015756254', 'display_name': 'Mariagrazia Uguccioni', 'orcid': 'https://orcid.org/0000-0002-9570-7011'}, 'institutions': [{'id': 'https://openalex.org/I118564535', 'display_name': 'University of Bern', 'ror': 'https://ror.org/02k7v4d05', 'country_code': 'CH', 'type': 'education', 'lineage': ['https://openalex.org/I118564535']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'M Uguccioni', 'raw_affiliation_strings': ['Theodor Kocher Institute, University of Bern, CH 3000, Bern 9, Switzerland'], 'affiliations': [{'raw_affiliation_string': 'Theodor Kocher Institute, University of Bern, CH 3000, Bern 9, Switzerland', 'institution_ids': ['https://openalex.org/I118564535']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068555063', 'display_name': 'Charles R. Mackay', 'orcid': 'https://orcid.org/0000-0002-6338-7340'}, 'institutions': [{'id': 'https://openalex.org/I4210140176', 'display_name': 'Takeda (United States)', 'ror': 'https://ror.org/03bygaq51', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210140176', 'https://openalex.org/I44892455']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'C R Mackay', 'raw_affiliation_strings': ['Takeda Pharmaceuticals (United States of America)'], 'affiliations': [{'raw_affiliation_string': 'Takeda Pharmaceuticals (United States of America)', 'institution_ids': ['https://openalex.org/I4210140176']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040964729', 'display_name': 'B Ochensberger', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2801112126', 'display_name': 'University Hospital of Bern', 'ror': 'https://ror.org/01q9sj412', 'country_code': 'CH', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801112126']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'B Ochensberger', 'raw_affiliation_strings': ['Inselspital Bern (University Hospital of Bern)'], 'affiliations': [{'raw_affiliation_string': 'Inselspital Bern (University Hospital of Bern)', 'institution_ids': ['https://openalex.org/I2801112126']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080531771', 'display_name': 'Pius Loetscher', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2801112126', 'display_name': 'University Hospital of Bern', 'ror': 'https://ror.org/01q9sj412', 'country_code': 'CH', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801112126']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'P Loetscher', 'raw_affiliation_strings': ['Inselspital Bern (University Hospital of Bern)'], 'affiliations': [{'raw_affiliation_string': 'Inselspital Bern (University Hospital of Bern)', 'institution_ids': ['https://openalex.org/I2801112126']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5096781284', 'display_name': 'S Rhis', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2801112126', 'display_name': 'University Hospital of Bern', 'ror': 'https://ror.org/01q9sj412', 'country_code': 'CH', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801112126']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'S Rhis', 'raw_affiliation_strings': ['Inselspital Bern (University Hospital of Bern)'], 'affiliations': [{'raw_affiliation_string': 'Inselspital Bern (University Hospital of Bern)', 'institution_ids': ['https://openalex.org/I2801112126']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109563984', 'display_name': 'G J LaRosa', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210140176', 'display_name': 'Takeda (United States)', 'ror': 'https://ror.org/03bygaq51', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210140176', 'https://openalex.org/I44892455']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'G J LaRosa', 'raw_affiliation_strings': ['Takeda Pharmaceuticals (United States of America)'], 'affiliations': [{'raw_affiliation_string': 'Takeda Pharmaceuticals (United States of America)', 'institution_ids': ['https://openalex.org/I4210140176']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037230570', 'display_name': 'Patricia E. Rao', 'orcid': 'https://orcid.org/0000-0003-2119-699X'}, 'institutions': [{'id': 'https://openalex.org/I4210140176', 'display_name': 'Takeda (United States)', 'ror': 'https://ror.org/03bygaq51', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210140176', 'https://openalex.org/I44892455']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'P Rao', 'raw_affiliation_strings': ['Takeda Pharmaceuticals (United States of America)'], 'affiliations': [{'raw_affiliation_string': 'Takeda Pharmaceuticals (United States of America)', 'institution_ids': ['https://openalex.org/I4210140176']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034292908', 'display_name': 'Paul Ponath', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210140176', 'display_name': 'Takeda (United States)', 'ror': 'https://ror.org/03bygaq51', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210140176', 'https://openalex.org/I44892455']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'P D Ponath', 'raw_affiliation_strings': ['Takeda Pharmaceuticals (United States of America)'], 'affiliations': [{'raw_affiliation_string': 'Takeda Pharmaceuticals (United States of America)', 'institution_ids': ['https://openalex.org/I4210140176']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004188962', 'display_name': 'Marco Baggiolini', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I118564535', 'display_name': 'University of Bern', 'ror': 'https://ror.org/02k7v4d05', 'country_code': 'CH', 'type': 'education', 'lineage': ['https://openalex.org/I118564535']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'M Baggiolini', 'raw_affiliation_strings': ['Universitat Bern (University of Bern)'], 'affiliations': [{'raw_affiliation_string': 'Universitat Bern (University of Bern)', 'institution_ids': ['https://openalex.org/I118564535']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5008098370', 'display_name': 'Clemens A. Dahinden', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2801112126', 'display_name': 'University Hospital of Bern', 'ror': 'https://ror.org/01q9sj412', 'country_code': 'CH', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801112126']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'C A Dahinden', 'raw_affiliation_strings': ['Inselspital Bern (University Hospital of Bern)'], 'affiliations': [{'raw_affiliation_string': 'Inselspital Bern (University Hospital of Bern)', 'institution_ids': ['https://openalex.org/I2801112126']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 5200, 'currency': 'USD', 'value_usd': 5200, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 14.179, 'has_fulltext': False, 'cited_by_count': 489, 'citation_normalized_percentile': {'value': 0.999856, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '100', 'issue': '5', 'first_page': '1137', 'last_page': '1143'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11346', 'display_name': 'Mast cells and histamine', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11346', 'display_name': 'Mast cells and histamine', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11020', 'display_name': 'Immune Cell Function and Interaction', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11532', 'display_name': 'Chemokine receptors and signaling', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/ccr3', 'display_name': 'CCR3', 'score': 0.8424022}, {'id': 'https://openalex.org/keywords/ccl13', 'display_name': 'CCL13', 'score': 0.6201412}, {'id': 'https://openalex.org/keywords/cc-chemokine-receptors', 'display_name': 'CC chemokine receptors', 'score': 0.6002403}, {'id': 'https://openalex.org/keywords/allergic-inflammation', 'display_name': 'Allergic Inflammation', 'score': 0.52239466}, {'id': 'https://openalex.org/keywords/ccr1', 'display_name': 'CCR1', 'score': 0.4435204}, {'id': 'https://openalex.org/keywords/monocyte', 'display_name': 'Monocyte', 'score': 0.41290578}, {'id': 'https://openalex.org/keywords/blocking-antibody', 'display_name': 'Blocking antibody', 'score': 0.4122815}], 'concepts': [{'id': 'https://openalex.org/C1423137', 'wikidata': 'https://www.wikidata.org/wiki/Q21113928', 'display_name': 'CCR3', 'level': 5, 'score': 0.8424022}, {'id': 'https://openalex.org/C2777456892', 'wikidata': 'https://www.wikidata.org/wiki/Q107988', 'display_name': 'Basophil', 'level': 4, 'score': 0.75966513}, {'id': 'https://openalex.org/C2777716647', 'wikidata': 'https://www.wikidata.org/wiki/Q5381961', 'display_name': 'Eotaxin', 'level': 4, 'score': 0.705521}, {'id': 'https://openalex.org/C13373296', 'wikidata': 'https://www.wikidata.org/wiki/Q421866', 'display_name': 'Chemokine', 'level': 3, 'score': 0.6555697}, {'id': 'https://openalex.org/C29146819', 'wikidata': 'https://www.wikidata.org/wiki/Q21113975', 'display_name': 'CCL13', 'level': 5, 'score': 0.6201412}, {'id': 'https://openalex.org/C128879288', 'wikidata': 'https://www.wikidata.org/wiki/Q5009764', 'display_name': 'CC chemokine receptors', 'level': 5, 'score': 0.6002403}, {'id': 'https://openalex.org/C12823836', 'wikidata': 'https://www.wikidata.org/wiki/Q24720618', 'display_name': 'Chemokine receptor', 'level': 4, 'score': 0.59554285}, {'id': 'https://openalex.org/C2779675166', 'wikidata': 'https://www.wikidata.org/wiki/Q4732119', 'display_name': 'Allergic inflammation', 'level': 3, 'score': 0.52239466}, {'id': 'https://openalex.org/C1122143', 'wikidata': 'https://www.wikidata.org/wiki/Q61233', 'display_name': 'Histamine', 'level': 2, 'score': 0.5098583}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.472036}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.4510944}, {'id': 'https://openalex.org/C129013479', 'wikidata': 'https://www.wikidata.org/wiki/Q21111916', 'display_name': 'CCR1', 'level': 5, 'score': 0.4435204}, {'id': 'https://openalex.org/C2777037409', 'wikidata': 'https://www.wikidata.org/wiki/Q107238', 'display_name': 'Eosinophil', 'level': 3, 'score': 0.42919314}, {'id': 'https://openalex.org/C2781184567', 'wikidata': 'https://www.wikidata.org/wiki/Q107244', 'display_name': 'Monocyte', 'level': 2, 'score': 0.41290578}, {'id': 'https://openalex.org/C45121317', 'wikidata': 'https://www.wikidata.org/wiki/Q4927287', 'display_name': 'Blocking antibody', 'level': 3, 'score': 0.4122815}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.39324737}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.31425565}, {'id': 'https://openalex.org/C159654299', 'wikidata': 'https://www.wikidata.org/wiki/Q79460', 'display_name': 'Antibody', 'level': 2, 'score': 0.23129815}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.16372505}, {'id': 'https://openalex.org/C141105273', 'wikidata': 'https://www.wikidata.org/wiki/Q79455', 'display_name': 'Immunoglobulin E', 'level': 3, 'score': 0.15767986}, {'id': 'https://openalex.org/C2776042228', 'wikidata': 'https://www.wikidata.org/wiki/Q35869', 'display_name': 'Asthma', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001491', 'descriptor_name': 'Basophils', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D018925', 'descriptor_name': 'Chemokines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D019742', 'descriptor_name': 'Chemokines, CC', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D018945', 'descriptor_name': 'Monocyte Chemoattractant Proteins', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D019707', 'descriptor_name': 'Receptors, Chemokine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D018121', 'descriptor_name': 'Receptors, Cytokine', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D001491', 'descriptor_name': 'Basophils', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054413', 'descriptor_name': 'Chemokine CCL11', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018946', 'descriptor_name': 'Chemokine CCL5', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D018946', 'descriptor_name': 'Chemokine CCL5', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018925', 'descriptor_name': 'Chemokines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002633', 'descriptor_name': 'Chemotaxis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006636', 'descriptor_name': 'Histamine Release', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018945', 'descriptor_name': 'Monocyte Chemoattractant Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054397', 'descriptor_name': 'Receptors, CCR3', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018121', 'descriptor_name': 'Receptors, Cytokine', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D018121', 'descriptor_name': 'Receptors, Cytokine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1172/jci119624', 'pdf_url': 'http://www.jci.org/articles/view/119624/files/pdf', 'source': {'id': 'https://openalex.org/S114430552', 'display_name': 'Journal of Clinical Investigation', 'issn_l': '0021-9738', 'issn': ['0021-9738', '1558-8238'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320279', 'host_organization_name': 'American Society for Clinical Investigation', 'host_organization_lineage': ['https://openalex.org/P4310320279'], 'host_organization_lineage_names': ['American Society for Clinical Investigation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc508288', 'pdf_url': 'https://europepmc.org/articles/pmc508288?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC508288', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/9276730', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1172/jci119624', 'pdf_url': 'http://www.jci.org/articles/view/119624/files/pdf', 'source': {'id': 'https://openalex.org/S114430552', 'display_name': 'Journal of Clinical Investigation', 'issn_l': '0021-9738', 'issn': ['0021-9738', '1558-8238'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320279', 'host_organization_name': 'American Society for Clinical Investigation', 'host_organization_lineage': ['https://openalex.org/P4310320279'], 'host_organization_lineage_names': ['American Society for Clinical Investigation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 46, 'referenced_works': ['https://openalex.org/W1522506802', 'https://openalex.org/W1530360057', 'https://openalex.org/W1604941563', 'https://openalex.org/W1624006515', 'https://openalex.org/W1780460389', 'https://openalex.org/W1831019962', 'https://openalex.org/W1964002710', 'https://openalex.org/W1965019797', 'https://openalex.org/W1971148540', 'https://openalex.org/W1973724657', 'https://openalex.org/W1989142540', 'https://openalex.org/W1989701896', 'https://openalex.org/W1990679519', 'https://openalex.org/W1996183144', 'https://openalex.org/W2004290834', 'https://openalex.org/W2021660658', 'https://openalex.org/W2023520187', 'https://openalex.org/W2030279593', 'https://openalex.org/W2037061225', 'https://openalex.org/W2042412331', 'https://openalex.org/W2045968396', 'https://openalex.org/W2048365572', 'https://openalex.org/W2056762910', 'https://openalex.org/W2060088029', 'https://openalex.org/W2063541345', 'https://openalex.org/W2067403399', 'https://openalex.org/W2073863059', 'https://openalex.org/W2089237353', 'https://openalex.org/W2099768074', 'https://openalex.org/W2100330873', 'https://openalex.org/W2110570736', 'https://openalex.org/W2113736505', 'https://openalex.org/W2124328573', 'https://openalex.org/W2131376910', 'https://openalex.org/W2131871620', 'https://openalex.org/W2132879755', 'https://openalex.org/W2144634347', 'https://openalex.org/W2152108405', 'https://openalex.org/W2154552023', 'https://openalex.org/W2156936329', 'https://openalex.org/W2160272188', 'https://openalex.org/W2166567151', 'https://openalex.org/W2256163298', 'https://openalex.org/W2278441769', 'https://openalex.org/W2314225431', 'https://openalex.org/W4242118976'], 'related_works': ['https://openalex.org/W4313333673', 'https://openalex.org/W4250503921', 'https://openalex.org/W3154902925', 'https://openalex.org/W2997009862', 'https://openalex.org/W2019143025', 'https://openalex.org/W2015406127', 'https://openalex.org/W2012387879', 'https://openalex.org/W1993565072', 'https://openalex.org/W1625023408', 'https://openalex.org/W1511309136'], 'abstract_inverted_index': {'Eosinophil': [0], 'leukocytes': [1], 'express': [2], 'high': [3], 'numbers': [4], 'of': [5, 78, 92, 102, 105, 125, 222], 'the': [6, 76, 98, 106, 113, 131, 153, 161, 166, 199, 218], 'chemokine': [7], 'receptor': [8, 201], 'CCR3': [9, 28, 197, 228], 'which': [10, 96, 176, 216], 'binds': [11], 'eotaxin,': [12, 117, 149, 203], 'monocyte': [13], 'chemotactic': [14], 'protein': [15], '(MCP)-4,': [16], 'and': [17, 42, 45, 50, 68, 71, 80, 94, 119, 144, 150, 157, 172, 181, 205, 210, 214], 'some': [18], 'other': [19], 'CC': [20], 'chemokines.': [21], 'In': [22, 159], 'this': [23], 'paper': [24], 'we': [25], 'show': [26], 'that': [27, 91, 196, 212], 'is': [29, 198], 'also': [30, 74, 138], 'highly': [31], 'expressed': [32, 67], 'on': [33, 179, 227], 'human': [34, 208], 'blood': [35], 'basophils,': [36, 84, 209], 'as': [37, 60], 'indicated': [38], 'by': [39, 116, 120, 148, 169, 187], 'Northern': [40, 188], 'blotting': [41, 189], 'flow': [43], 'cytometry,': [44], 'mediates': [46], 'mainly': [47], 'chemotaxis.': [48], 'Eotaxin': [49], 'MCP-4': [51, 206], 'elicited': [52], 'basophil': [53, 191], 'migration': [54, 114, 230], 'in': [55, 82, 207], 'vitro': [56], 'with': [57, 108, 190], 'similar': [58], 'efficacy': [59, 87], 'regulated': [61], 'upon': [62], 'activation': [63], 'normal': [64], 'T': [65], 'cells': [66, 221], 'secreted': [69], '(RANTES)': [70], 'MCP-3.': [72, 134], 'They': [73], 'induced': [75, 115, 147, 168], 'release': [77, 146], 'histamine': [79, 143], 'leukotrienes': [81], 'IL-3-primed': [83], 'but': [85, 127], 'their': [86], 'was': [88], 'lower': [89], 'than': [90], 'MCP-1': [93], 'MCP-3,': [95, 171], 'were': [97], 'most': [99], 'potent': [100], 'stimuli': [101], 'exocytosis.': [103], 'Pretreatment': [104], 'basophils': [107, 213], 'a': [109], 'CCR3-blocking': [110, 136], 'antibody': [111, 137, 162], 'abrogated': [112, 142], 'RANTES,': [118, 204], 'low': [121], 'to': [122, 133, 155], 'optimal': [123], 'concentrations': [124], 'MCP-4,': [126], 'decreased': [128], 'only': [129], 'minimally': [130], 'response': [132, 154], 'The': [135], 'affected': [139], 'exocytosis:': [140], 'it': [141], 'leukotriene': [145], 'partially': [151], 'inhibited': [152], 'RANTES': [156], 'MCP-4.': [158], 'contrast,': [160], 'did': [163], 'not': [164], 'affect': [165], 'responses': [167], 'MCP-1,': [170], 'macrophage': [173], 'inflammatory': [174], 'protein-1alpha,': [175], 'may': [177], 'depend': [178, 225], 'CCR1': [180], 'CCR2,': [182], 'two': [183], 'additional': [184], 'receptors': [185], 'detected': [186], 'RNA.': [192], 'This': [193], 'study': [194], 'demonstrates': [195], 'major': [200], 'for': [202, 229], 'suggests': [211], 'eosinophils,': [215], 'are': [217], 'characteristic': [219], 'effector': [220], 'allergic': [223], 'inflammation,': [224], 'largely': [226], 'towards': [231], 'different': [232], 'chemokines': [233], 'into': [234], 'inflamed': [235], 'tissues.': [236]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2048988599', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 10}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 10}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 7}, {'year': 2017, 'cited_by_count': 8}, {'year': 2016, 'cited_by_count': 11}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 11}, {'year': 2013, 'cited_by_count': 19}, {'year': 2012, 'cited_by_count': 7}], 'updated_date': '2024-12-11T19:06:48.376586', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
