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57, 1667], 'C.': [37, 58, 60, 1668], 'Jones,': [38], 'Nicholas': [39, 63, 1675], 'Bruchovsky,': [40], 'Lorne': [42, 68, 1682], 'D.': [43, 69, 71, 1683], 'Sullivan': [44, 72, 1605, 1684], 'GleaveMartin': [47], 'Gleave': [49, 1653], ',': [50, 56, 62, 66], 'GoldenbergS.': [53], 'Goldenberg': [55, 1598, 1661], 'JonesEdward': [59], 'Jones': [61, 1669], 'BruchovskyNicholas': [64], 'Bruchovsky': [65, 1602, 1676], 'SullivanLorne': [70], 'View': [73], 'All': [74, 1691], 'Author': [75], 'Informationhttps://doi.org/10.1016/S0022-5347(01)66598-4AboutFull': [76], 'TextPDF': [77], 'ToolsAdd': [78], 'to': [79, 93, 106, 117, 206, 316, 487, 649], 'favoritesDownload': [80], 'CitationsTrack': [81], 'CitationsPermissionsReprints': [82], 'ShareFacebookLinked': [83], 'InTwitterEmail': [84], 'Abstract': [85], 'Purpose:': [86], 'A': [87, 905, 1161, 1282, 1294, 1401, 1431, 1486, 1568], 'prospective,': [88], 'nonrandomized': [89], 'trial': [90], 'was': [91, 242, 261], 'initiated': [92], 'determine': [94], 'the': [95, 111, 128, 221, 238, 246, 300, 371, 452, 467, 577, 626, 634, 693, 768, 849, 885, 928, 933, 987, 1036, 1060, 1083, 1090, 1107, 1620], 'duration': [96], 'neo-adjuvant': [98], 'therapy': [99, 135, 343, 688, 748, 1055], 'required': [100], 'for': [101, 412, 430, 447, 631, 1572], 'prostate': [102, 157, 409, 434, 453, 536, 598, 684, 709, 717, 743, 751, 771, 787, 955, 1012, 1031, 1065, 1116], 'specific': [103, 537, 573, 599, 620, 710, 744, 1032, 1080], 'antigen': [104, 306, 538, 574, 600, 711, 745, 1033, 1081], '(PSA)': [105, 575], 'reach': [107], 'its': [108, 215], 'nadir,': [109], 'evaluate': [110], 'ability': [112], 'an': [114, 200, 902], 'ultrasensitive': [115, 201], 'assay': [116], 'measure': [118], 'decreases': [119], 'PSA': [121, 171, 180, 204, 268, 351, 359, 366], 'less': [122], 'than': [123, 210], '0.2': [124], 'microgram/l.,': [125], 'characterize': [127], 'effects': [129], 'months': [132, 162, 230, 338], 'neoadjuvant': [134, 334, 340, 667, 687, 1051], 'on': [136, 282, 866, 878, 927, 1577], 'pathological': [137], 'stage,': [138], 'positive': [139, 239, 258, 347, 389, 458], 'margin': [140, 240, 259, 348, 479], 'rates,': [141], 'proliferation': [142, 301, 303, 951], 'tumor': [144, 377, 491, 493, 497, 629, 723, 911], 'marker': [145, 630], 'immuno-staining.': [146], 'Materials': [147], 'Methods:': [149], 'We': [150], 'evaluated': [151], '50': [152], 'patients': [153, 448, 580, 1008], 'clinically': [155], 'localized': [156, 671, 683, 1064], 'cancer': [158, 292, 685, 818, 956, 974, 976], 'treated': [159, 1094], 'by': [160, 182, 189, 686, 722, 832, 1145, 1645, 1656, 1664, 1672, 1679, 1687], 'reversible': [164, 1052], 'androgen': [165, 326, 341, 364, 646, 765, 876, 925, 948, 1024, 1053], 'ablation': [166], 'before': [167, 1159], 'radical': [168, 393, 428, 455, 482, 540, 582, 608], 'prostatectomy.': [169, 541, 609], 'Serum': [170, 179, 571, 708, 1579], 'testosterone': [173, 898], 'levels': [174, 208, 533, 712], 'were': [175, 250, 255], 'measured': [176], 'monthly.': [177], 'Results:': [178], 'decreased': [181, 205, 310], '84': [183, 232], 'percent': [184, 193, 219, 227, 233, 249, 254], 'after': [185, 223, 228, 234, 264, 539, 581, 607, 746], '1': [186, 380], 'month': [187], 'a': [190, 622, 651], 'further': [191], '52': [192], 'between': [194, 908], '3': [195, 224, 423, 1256], 'months.': [198, 236], 'Using': [199], 'assay,': [202], 'serum': [203, 535, 742, 879, 1030], 'undetectable': [207], '(less': [209], '0.1': [211], 'microgram/l.)': [212], 'or': [213, 813, 1171], 'reached': [214], 'nadir': [216, 352], '22': [218, 893], 'cases': [222, 247, 277], 'months,': [225], '42': [226], '5': [229, 476], 'Overall,': [237], 'rate': [241, 260], '4': [243, 276, 443], 'percent.': [244], 'Of': [245], '68': [248], 'organ-confined': [251], '24': [253, 942], 'specimen-confined.': [256], 'The': [257, 354, 527, 664, 738, 895], 'not': [262, 330], 'increased': [263], 'reevaluation': [265], 'cytokeratin,': [267], 'prostatic': [270, 294, 514, 572, 672, 867, 1110], 'acid': [271, 295, 1111], 'phosphatase': [272, 296, 1112], 'immuno-staining': [273], 'but': [274], 'initially': [278], 'staged': [279], 'as': [280, 415], 'P0': [281], 'hematoxylin': [283], 'eosin': [285], 'evaluation': [286], '2': [287, 403], 'had': [288], 'microscopic': [289], 'foci': [290], 'staining.': [297], 'Immuno-staining': [298], 'markers': [302], 'cell': [304, 930], 'nuclear': [305], 'Ki-67': [308], 'showed': [309], 'staining': [311], 'surgical': [313, 390, 459, 1061], 'specimens': [314], 'relative': [315], 'pretreatment': [317], 'needle': [318], 'biopsy': [319], 'specimens,': [320], 'which': [321], 'suggests': [322], 'that': [323], 'outgrowth': [324], 'independent': [327], 'clones': [328], 'does': [329], 'develop': [331], 'during': [332], 'prolonged': [333], 'therapy.': [335, 417, 977], 'Conclusions:': [336], 'Eight': [337], 'withdrawal': [342, 926, 1054], 'results': [344, 360], 'low': [346], 'rates': [349], 'levels.': [353], 'initial': [355], 'rapid': [356], 'decrease': [357, 374], 'from': [361], 'cessation': [362], 'regulated': [365], 'synthesis': [367], 'apoptosis,': [369], 'while': [370], 'ongoing': [372], 'slower': [373], 'reflects': [375], 'decreasing': [376], 'volume.': [378], 'References': [379], ':': [381, 404, 424, 444, 477, 507, 526, 552, 570, 596, 618, 644, 663, 680, 707, 737, 763, 781, 846, 864, 894, 922, 943, 969, 984, 1003, 1022, 1046, 1078, 1104], 'Frequency': [382], 'location': [384], 'extracapsular': [386], 'extension': [387], 'margins': [391], 'prostatectomy': [394, 429, 456, 484, 583, 807], 'specimens.': [395], 'J.': [396, 436, 469, 499, 518, 542, 585, 610, 636, 753, 1014, 1038, 1067, 1096], 'Urol.1992;': [397], '148:': [398], '331.': [399], 'Link,': [400, 440, 473, 503, 522, 614, 640, 1018, 1100], 'Google': [401, 421, 441, 474, 504, 523, 549, 567, 593, 615, 641, 660, 677, 704, 734, 760, 778, 795, 843, 861, 891, 919, 940, 966, 981, 1000, 1019, 1043, 1075, 1101, 1125], 'Scholar': [402, 422, 442, 475, 505, 524, 550, 568, 594, 616, 642, 661, 678, 705, 735, 761, 779, 796, 844, 862, 892, 920, 941, 967, 982, 1001, 1020, 1044, 1076, 1102, 1126], 'Understaging': [405], 'undergrading': [407], 'cancer:': [410, 772], 'argument': [411], 'postoperative': [413], 'radiation': [414], 'adjuvant': [416], 'Urology1983;': [418], '21:': [419], '113.': [420], 'Role': [425], 'nerve-sparing': [427], 'clinical': [431, 602, 739], 'stage': [432], 'B2': [433], 'cancer.': [435, 673, 752, 788, 1013, 1066], 'Urol.1990;': [437, 500], '144:': [438, 501], '1420.': [439], 'Postoperative': [445], 'radiotherapy': [446], 'carcinoma': [450, 883, 1117], 'undergoing': [454, 992], 'margins,': [460], 'seminal': [461], 'vesicle': [462], 'involvement': [463], 'and/or': [464], 'penetration': [465], 'through': [466], 'capsule.': [468], 'Urol.1987;': [470, 519], '138:': [471, 520], '1407.': [472], 'Resection': [478], 'status': [480], 'retropubic': [483, 806], 'specimens:': [485], 'relationship': [486], 'type': [488], 'operation,': [490], 'size,': 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'antigen:': [621], 'critical': [623, 655], 'assessment': [624], 'most': [627], 'useful': [628], 'adenocarcinoma': [632, 1088], 'prostate.': [635, 886, 1091], 'Urol.1991;': [637], '145:': [638], '907.': [639], '12': [643], 'blockade': [647], 'prior': [648], 'retrospective': [652], 'study': [653, 1049], 'review.': [656], 'Prostate1994;': [657], '5:': [658], '9.': [659], '13': [662], 'role': [665], 'hormonal': [668, 747, 1005], 'manipulation': [669], 'Cancer1993;': [674], '71:': [675], '1031.': [676], '14': [679], 'Downstaging': [681], 'flutanide': [690], 'lupron:': [692], 'first': [694], 'controlled': [695, 1048], 'randomized': [697], 'trial.': [698], 'Clin.': [699, 790, 857], 'Invest.': [700], 'Med.1993;': [701], '16:': [702], '499.': [703], '15': [706], 'mice': [714], 'bearing': [715], 'human': [716, 954, 1115], 'LNCaP': [718, 1114], 'tumors': [719], 'are': [720], 'determined': [721], 'volume': [724], 'endocrine': [726], 'growth': [728, 912], 'factors.': [729], 'Res.1992;': [731], '52:': [732], '1598.': [733], '16': [736], 'usefulness': [740], 'metastatic': [750, 882], '21992;': [756], '147:': [757], '956.': [758], '17': [762], 'Intermittent': [764], 'suppression': [766], 'preliminary': [773], 'report.': [774], 'Urology1995;': [775], '45:': [776], '839.': [777], '18': [780], 'Use': [782], 'cyproterone': [784, 1057], 'acetate': [785, 1058], 'Urol.': [789], 'N.': [791], 'Amer.1991;': [792], '18:': [793], '111.': [794], '19': [797], 'Stephenson,': [798], 'R.': [799, 803, 833], 'A.': [800], 'Middleton,': [802], 'G.:': [804], 'using': [808], 'wide': [809], 'excision': [810], '(non-nerve': [811], 'sparing)': [812], 'nerve': [814], 'sparing': [815], 'techniques;': [816], 'improved': [817], 'control': [819], 'vs.': [820], 'potency': [821], 'preservation.': [822], 'In:': [823], 'Medical': [824, 839], 'Management': [827], 'Cancer.': [830], 'Edited': [831], 'G.': [834], 'Middleton.': [835], 'New': [836], 'York:': [837], 'Igaku-Shoin': [838], 'Publishers,': [840], 'press.': 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