Title: Low serum VEGF levels are associated with Alzheimer's disease
Abstract: Acta Neurologica ScandinavicaVolume 116, Issue 1 p. 56-58 Low serum VEGF levels are associated with Alzheimer's disease I. Mateo, I. Mateo Neurology Service, ‘Marqués de Valdecilla’ University Hospital, University of Cantabria, Santander, SpainSearch for more papers by this authorJ. Llorca, J. Llorca Division of Preventive Medicine, University of Cantabria School of Medicine, Santander, SpainSearch for more papers by this authorJ. Infante, J. Infante Neurology Service, ‘Marqués de Valdecilla’ University Hospital, University of Cantabria, Santander, SpainSearch for more papers by this authorE. Rodríguez-Rodríguez, E. Rodríguez-Rodríguez Neurology Service, ‘Marqués de Valdecilla’ University Hospital, University of Cantabria, Santander, SpainSearch for more papers by this authorC. Fernández-Viadero, C. Fernández-Viadero RTE Santander, Consejería de Sanidad, Santander, SpainSearch for more papers by this authorN. Peña, N. Peña RTE Santander, Consejería de Sanidad, Santander, SpainSearch for more papers by this authorJ. Berciano, J. Berciano Neurology Service, ‘Marqués de Valdecilla’ University Hospital, University of Cantabria, Santander, SpainSearch for more papers by this authorO. Combarros, O. Combarros Neurology Service, ‘Marqués de Valdecilla’ University Hospital, University of Cantabria, Santander, SpainSearch for more papers by this author I. Mateo, I. Mateo Neurology Service, ‘Marqués de Valdecilla’ University Hospital, University of Cantabria, Santander, SpainSearch for more papers by this authorJ. Llorca, J. Llorca Division of Preventive Medicine, University of Cantabria School of Medicine, Santander, SpainSearch for more papers by this authorJ. Infante, J. Infante Neurology Service, ‘Marqués de Valdecilla’ University Hospital, University of Cantabria, Santander, SpainSearch for more papers by this authorE. Rodríguez-Rodríguez, E. Rodríguez-Rodríguez Neurology Service, ‘Marqués de Valdecilla’ University Hospital, University of Cantabria, Santander, SpainSearch for more papers by this authorC. Fernández-Viadero, C. Fernández-Viadero RTE Santander, Consejería de Sanidad, Santander, SpainSearch for more papers by this authorN. Peña, N. Peña RTE Santander, Consejería de Sanidad, Santander, SpainSearch for more papers by this authorJ. Berciano, J. Berciano Neurology Service, ‘Marqués de Valdecilla’ University Hospital, University of Cantabria, Santander, SpainSearch for more papers by this authorO. Combarros, O. Combarros Neurology Service, ‘Marqués de Valdecilla’ University Hospital, University of Cantabria, Santander, SpainSearch for more papers by this author First published: 06 December 2006 https://doi.org/10.1111/j.1600-0404.2006.00775.xCitations: 66 Onofre Combarros, Neurology Service, University Hospital ‘Marqués de Valdecilla’, 39008 Santander, SpainTel.: +34 942 202520fax: +34 942 202655e-mail: [email protected] Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Objective – As vascular endothelial growth factor (VEGF) determines important neurotrophic and neuroprotective actions, we postulated serum VEGF levels could be abnormally low in patients with Alzheimer's disease (AD). Methods – We measured serum VEGF levels (VEGF165 isoform by ELISA) in 51 patients with AD by National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and Related Disorder Association criteria and compared with 66 age- and gender-matched non-demented controls. Patients with AD were stratified into levels of dementia severity by the Clinical Dementia Rating scale. Serum VEGF levels were stratified into upper (>309 pg/ml), middle (207–309 pg/ml), and lower (<207 pg/ml) tertiles. VEGF (−2578) (rs 699947) and VEGF (−634) (rs 2010963) polymorphisms were genotyped in patients with AD and controls. Results – The mean concentration of VEGF in the serum of patients with AD (215.9 pg/ml, SD 101.5) was significantly lower than that of the controls (308.6 pg/ml, SD 223.9, P = 0.004), and decreased serum VEGF levels were associated with AD in a dose-dependent manner, the lower tertile of serum VEGF levels being associated with a fivefold increased risk for AD when compared with the upper tertile. There was no significant correlation between serum VEGF levels and age, sex, APOE alleles, AD dementia severity nor VEGF gene polymorphisms. Conclusion – Decrease in serum VEGF levels could contribute to the neurodegenerative process in AD. Citing Literature Volume116, Issue1July 2007Pages 56-58 RelatedInformation
Publication Year: 2007
Publication Date: 2007-07-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 118
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