Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2048389644', 'doi': 'https://doi.org/10.1242/dev.01436', 'title': '<i>Hes</i>genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation', 'display_name': '<i>Hes</i>genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation', 'publication_year': 2004, 'publication_date': '2004-11-15', 'ids': {'openalex': 'https://openalex.org/W2048389644', 'doi': 'https://doi.org/10.1242/dev.01436', 'mag': '2048389644', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/15496443'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1242/dev.01436', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S86558740', 'display_name': 'Development', 'issn_l': '0950-1991', 'issn': ['0950-1991', '1477-9129'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311847', 'host_organization_name': 'The Company of Biologists', 'host_organization_lineage': ['https://openalex.org/P4310311847'], 'host_organization_lineage_names': ['The Company of Biologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://doi.org/10.1242/dev.01436', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5033165469', 'display_name': 'Jun Hatakeyama', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I22299242', 'display_name': 'Kyoto University', 'ror': 'https://ror.org/02kpeqv85', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I22299242']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Jun Hatakeyama', 'raw_affiliation_strings': ['Institute for Virus Research, Kyoto University, Kyoto 606-8507, Japan'], 'affiliations': [{'raw_affiliation_string': 'Institute for Virus Research, Kyoto University, Kyoto 606-8507, Japan', 'institution_ids': ['https://openalex.org/I22299242']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069703127', 'display_name': 'Yasumasa Bessho', 'orcid': 'https://orcid.org/0000-0002-4404-8239'}, 'institutions': [{'id': 'https://openalex.org/I22299242', 'display_name': 'Kyoto University', 'ror': 'https://ror.org/02kpeqv85', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I22299242']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yasumasa Bessho', 'raw_affiliation_strings': ['Institute for Virus Research, Kyoto University, Kyoto 606-8507, Japan'], 'affiliations': [{'raw_affiliation_string': 'Institute for Virus Research, Kyoto University, Kyoto 606-8507, Japan', 'institution_ids': ['https://openalex.org/I22299242']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101568049', 'display_name': 'Kazuo Katoh', 'orcid': 'https://orcid.org/0000-0002-5766-708X'}, 'institutions': [{'id': 'https://openalex.org/I146500386', 'display_name': 'Jichi Medical University', 'ror': 'https://ror.org/010hz0g26', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I146500386']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kazuo Katoh', 'raw_affiliation_strings': ['Department of Anatomy, Jichi Medical School, Tochigi 329-0498, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Anatomy, Jichi Medical School, Tochigi 329-0498, Japan', 'institution_ids': ['https://openalex.org/I146500386']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008465604', 'display_name': 'Shigeo Ookawara', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I146500386', 'display_name': 'Jichi Medical University', 'ror': 'https://ror.org/010hz0g26', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I146500386']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Shigeo Ookawara', 'raw_affiliation_strings': ['Department of Anatomy, Jichi Medical School, Tochigi 329-0498, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Anatomy, Jichi Medical School, Tochigi 329-0498, Japan', 'institution_ids': ['https://openalex.org/I146500386']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025551300', 'display_name': 'Makio Fujioka', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I22299242', 'display_name': 'Kyoto University', 'ror': 'https://ror.org/02kpeqv85', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I22299242']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Makio Fujioka', 'raw_affiliation_strings': ['Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan'], 'affiliations': [{'raw_affiliation_string': 'Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan', 'institution_ids': ['https://openalex.org/I22299242']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025250272', 'display_name': 'François Guillemot', 'orcid': 'https://orcid.org/0000-0003-0432-5067'}, 'institutions': [], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'François Guillemot', 'raw_affiliation_strings': ['National Institute for Medical Research, Mill Hill, London, NW7 1AA, UK'], 'affiliations': [{'raw_affiliation_string': 'National Institute for Medical Research, Mill Hill, London, NW7 1AA, UK', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5018917055', 'display_name': 'Ryoichiro Kageyama', 'orcid': 'https://orcid.org/0000-0002-5985-1120'}, 'institutions': [{'id': 'https://openalex.org/I22299242', 'display_name': 'Kyoto University', 'ror': 'https://ror.org/02kpeqv85', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I22299242']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Ryoichiro Kageyama', 'raw_affiliation_strings': ['Institute for Virus Research, Kyoto University, Kyoto 606-8507, Japan'], 'affiliations': [{'raw_affiliation_string': 'Institute for Virus Research, Kyoto University, Kyoto 606-8507, Japan', 'institution_ids': ['https://openalex.org/I22299242']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 9.039, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 556, 'citation_normalized_percentile': {'value': 0.998858, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '131', 'issue': '22', 'first_page': '5539', 'last_page': '5550'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10608', 'display_name': 'Adult Neurogenesis and Brain Development', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/2806', 'display_name': 'Developmental Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10608', 'display_name': 'Adult Neurogenesis and Brain Development', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/2806', 'display_name': 'Developmental Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12061', 'display_name': 'Molecular Mechanisms of Axon Guidance', 'score': 0.9941, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10268', 'display_name': 'Notch Signaling Pathway in Development and Disease', 'score': 0.9926, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/neuroepithelial-cell', 'display_name': 'Neuroepithelial cell', 'score': 0.9754231}, {'id': 'https://openalex.org/keywords/organogenesis', 'display_name': 'Organogenesis', 'score': 0.6447034}, {'id': 'https://openalex.org/keywords/neurosphere', 'display_name': 'Neurosphere', 'score': 0.5878338}, {'id': 'https://openalex.org/keywords/neurogenesis', 'display_name': 'Neurogenesis', 'score': 0.573453}, {'id': 'https://openalex.org/keywords/neural-development', 'display_name': 'Neural Development', 'score': 0.568213}, {'id': 'https://openalex.org/keywords/hippocampal-neurogenesis', 'display_name': 'Hippocampal Neurogenesis', 'score': 0.540348}, {'id': 'https://openalex.org/keywords/neural-stem-cells', 'display_name': 'Neural Stem Cells', 'score': 0.531608}, {'id': 'https://openalex.org/keywords/neurogenic-niches', 'display_name': 'Neurogenic Niches', 'score': 0.530162}, {'id': 'https://openalex.org/keywords/hes1', 'display_name': 'HES1', 'score': 0.43317017}, {'id': 'https://openalex.org/keywords/forebrain', 'display_name': 'Forebrain', 'score': 0.42993653}], 'concepts': [{'id': 'https://openalex.org/C200707615', 'wikidata': 'https://www.wikidata.org/wiki/Q13652744', 'display_name': 'Neuroepithelial cell', 'level': 4, 'score': 0.9754231}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.8674746}, {'id': 'https://openalex.org/C136834591', 'wikidata': 'https://www.wikidata.org/wiki/Q2944097', 'display_name': 'Neural stem cell', 'level': 3, 'score': 0.6678878}, {'id': 'https://openalex.org/C30503417', 'wikidata': 'https://www.wikidata.org/wiki/Q958938', 'display_name': 'Organogenesis', 'level': 3, 'score': 0.6447034}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.64048433}, {'id': 'https://openalex.org/C162746124', 'wikidata': 'https://www.wikidata.org/wiki/Q7002675', 'display_name': 'Neurosphere', 'level': 5, 'score': 0.5878338}, {'id': 'https://openalex.org/C2780594696', 'wikidata': 'https://www.wikidata.org/wiki/Q1127402', 'display_name': 'Neural tube', 'level': 3, 'score': 0.58540946}, {'id': 'https://openalex.org/C28328180', 'wikidata': 'https://www.wikidata.org/wiki/Q48196', 'display_name': 'Stem cell', 'level': 2, 'score': 0.5456158}, {'id': 'https://openalex.org/C148738053', 'wikidata': 'https://www.wikidata.org/wiki/Q210861', 'display_name': 'Cellular differentiation', 'level': 3, 'score': 0.50415766}, {'id': 'https://openalex.org/C145103041', 'wikidata': 'https://www.wikidata.org/wiki/Q1151519', 'display_name': 'Embryonic stem cell', 'level': 3, 'score': 0.5003915}, {'id': 'https://openalex.org/C4746552', 'wikidata': 'https://www.wikidata.org/wiki/Q1456827', 'display_name': 'Neurogenesis', 'level': 2, 'score': 0.49924397}, {'id': 'https://openalex.org/C2780283210', 'wikidata': 'https://www.wikidata.org/wiki/Q18027301', 'display_name': 'HES1', 'level': 4, 'score': 0.43317017}, {'id': 'https://openalex.org/C2779715522', 'wikidata': 'https://www.wikidata.org/wiki/Q507027', 'display_name': 'Forebrain', 'level': 3, 'score': 0.42993653}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.4226573}, {'id': 'https://openalex.org/C461258', 'wikidata': 'https://www.wikidata.org/wiki/Q1345738', 'display_name': 'Neural development', 'level': 3, 'score': 0.41446668}, {'id': 'https://openalex.org/C20875687', 'wikidata': 'https://www.wikidata.org/wiki/Q2642600', 'display_name': 'Adult stem cell', 'level': 4, 'score': 0.36854398}, {'id': 'https://openalex.org/C529278444', 'wikidata': 'https://www.wikidata.org/wiki/Q47273', 'display_name': 'Central nervous system', 'level': 2, 'score': 0.18609634}, {'id': 'https://openalex.org/C196843134', 'wikidata': 'https://www.wikidata.org/wiki/Q33196', 'display_name': 'Embryo', 'level': 2, 'score': 0.15603226}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.14033571}, {'id': 'https://openalex.org/C161879069', 'wikidata': 'https://www.wikidata.org/wiki/Q904082', 'display_name': 'Notch signaling pathway', 'level': 3, 'score': 0.092273235}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.07803723}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.07502881}], 'mesh': [{'descriptor_ui': 'D002454', 'descriptor_name': 'Cell Differentiation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D018398', 'descriptor_name': 'Homeodomain Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009420', 'descriptor_name': 'Nervous System', 'qualifier_ui': 'Q000196', 'qualifier_name': 'embryology', 'is_major_topic': True}, {'descriptor_ui': 'D012097', 'descriptor_name': 'Repressor Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D013234', 'descriptor_name': 'Stem Cells', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': True}, {'descriptor_ui': 'D013234', 'descriptor_name': 'Stem Cells', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001485', 'descriptor_name': 'Basement Membrane', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001485', 'descriptor_name': 'Basement Membrane', 'qualifier_ui': 'Q000196', 'qualifier_name': 'embryology', 'is_major_topic': False}, {'descriptor_ui': 'D001485', 'descriptor_name': 'Basement Membrane', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D001485', 'descriptor_name': 'Basement Membrane', 'qualifier_ui': 'Q000002', 'qualifier_name': 'abnormalities', 'is_major_topic': False}, {'descriptor_ui': 'D051792', 'descriptor_name': 'Basic Helix-Loop-Helix Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000172', 'qualifier_name': 'deficiency', 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D005124', 'descriptor_name': 'Eye Abnormalities', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005124', 'descriptor_name': 'Eye Abnormalities', 'qualifier_ui': 'Q000196', 'qualifier_name': 'embryology', 'is_major_topic': False}, {'descriptor_ui': 'D005124', 'descriptor_name': 'Eye Abnormalities', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D005124', 'descriptor_name': 'Eye Abnormalities', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018507', 'descriptor_name': 'Gene Expression Regulation, Developmental', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018398', 'descriptor_name': 'Homeodomain Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D018398', 'descriptor_name': 'Homeodomain Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017403', 'descriptor_name': 'In Situ Hybridization', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018345', 'descriptor_name': 'Mice, Knockout', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008855', 'descriptor_name': 'Microscopy, Electron, Scanning', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': 'Q000172', 'qualifier_name': 'deficiency', 'is_major_topic': False}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009420', 'descriptor_name': 'Nervous System', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D009420', 'descriptor_name': 'Nervous System', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009420', 'descriptor_name': 'Nervous System', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009457', 'descriptor_name': 'Neuroglia', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D009457', 'descriptor_name': 'Neuroglia', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009457', 'descriptor_name': 'Neuroglia', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D009457', 'descriptor_name': 'Neuroglia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012097', 'descriptor_name': 'Repressor Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012097', 'descriptor_name': 'Repressor Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D013116', 'descriptor_name': 'Spinal Cord', 'qualifier_ui': 'Q000002', 'qualifier_name': 'abnormalities', 'is_major_topic': False}, {'descriptor_ui': 'D013116', 'descriptor_name': 'Spinal Cord', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D013116', 'descriptor_name': 'Spinal Cord', 'qualifier_ui': 'Q000196', 'qualifier_name': 'embryology', 'is_major_topic': False}, {'descriptor_ui': 'D013116', 'descriptor_name': 'Spinal Cord', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D013116', 'descriptor_name': 'Spinal Cord', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013234', 'descriptor_name': 'Stem Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000072056', 'descriptor_name': 'Transcription Factor HES-1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1242/dev.01436', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S86558740', 'display_name': 'Development', 'issn_l': '0950-1991', 'issn': ['0950-1991', '1477-9129'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311847', 'host_organization_name': 'The Company of Biologists', 'host_organization_lineage': ['https://openalex.org/P4310311847'], 'host_organization_lineage_names': ['The Company of Biologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://hdl.handle.net/2433/144732', 'pdf_url': 'https://repository.kulib.kyoto-u.ac.jp/dspace/bitstream/2433/144732/1/yigak02831.pdf', 'source': {'id': 'https://openalex.org/S4306401454', 'display_name': 'Kyoto University Research Information Repository (Kyoto University)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I22299242', 'host_organization_name': 'Kyoto University', 'host_organization_lineage': ['https://openalex.org/I22299242'], 'host_organization_lineage_names': ['Kyoto University'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/15496443', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1242/dev.01436', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S86558740', 'display_name': 'Development', 'issn_l': '0950-1991', 'issn': ['0950-1991', '1477-9129'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311847', 'host_organization_name': 'The Company of Biologists', 'host_organization_lineage': ['https://openalex.org/P4310311847'], 'host_organization_lineage_names': ['The Company of Biologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 63, 'referenced_works': ['https://openalex.org/W1554042779', 'https://openalex.org/W158882695', 'https://openalex.org/W1589588578', 'https://openalex.org/W1643680178', 'https://openalex.org/W1899815911', 'https://openalex.org/W1935027408', 'https://openalex.org/W1936178817', 'https://openalex.org/W1966383348', 'https://openalex.org/W1970680825', 'https://openalex.org/W1976824219', 'https://openalex.org/W1980756779', 'https://openalex.org/W1981254630', 'https://openalex.org/W1984425610', 'https://openalex.org/W1984637659', 'https://openalex.org/W1993624454', 'https://openalex.org/W1994666066', 'https://openalex.org/W1994859370', 'https://openalex.org/W1997481445', 'https://openalex.org/W2000745458', 'https://openalex.org/W2001991657', 'https://openalex.org/W2004391147', 'https://openalex.org/W2005951087', 'https://openalex.org/W2015066175', 'https://openalex.org/W2015964634', 'https://openalex.org/W2017452389', 'https://openalex.org/W2018761763', 'https://openalex.org/W2023618495', 'https://openalex.org/W2023684878', 'https://openalex.org/W2031780222', 'https://openalex.org/W2047604499', 'https://openalex.org/W2050463587', 'https://openalex.org/W2055149141', 'https://openalex.org/W2057250698', 'https://openalex.org/W2058705034', 'https://openalex.org/W2068407791', 'https://openalex.org/W2077780809', 'https://openalex.org/W2078126797', 'https://openalex.org/W2082401415', 'https://openalex.org/W2083904945', 'https://openalex.org/W2088969512', 'https://openalex.org/W2094859123', 'https://openalex.org/W2095877450', 'https://openalex.org/W2097546542', 'https://openalex.org/W2100100832', 'https://openalex.org/W2100699398', 'https://openalex.org/W2102428207', 'https://openalex.org/W2111298441', 'https://openalex.org/W2114843411', 'https://openalex.org/W2116711648', 'https://openalex.org/W2120215029', 'https://openalex.org/W2136256418', 'https://openalex.org/W2136648925', 'https://openalex.org/W2138903858', 'https://openalex.org/W2140553945', 'https://openalex.org/W2146404892', 'https://openalex.org/W2154861644', 'https://openalex.org/W2157969772', 'https://openalex.org/W2170865129', 'https://openalex.org/W2171623512', 'https://openalex.org/W2188474087', 'https://openalex.org/W2345668379', 'https://openalex.org/W2471988819', 'https://openalex.org/W2887438214'], 'related_works': ['https://openalex.org/W4242539998', 'https://openalex.org/W3013346247', 'https://openalex.org/W2396603739', 'https://openalex.org/W2111786367', 'https://openalex.org/W2047618195', 'https://openalex.org/W2023884049', 'https://openalex.org/W1985216580', 'https://openalex.org/W1833171476', 'https://openalex.org/W173443861', 'https://openalex.org/W1551331657'], 'abstract_inverted_index': {'Radial': [0], 'glial': [1, 43, 134, 227], 'cells': [2, 19, 44, 50, 63, 127, 135, 208, 223], 'derive': [3], 'from': [4], 'neuroepithelial': [5, 126, 219, 222], 'cells,': [6], 'and': [7, 35, 42, 67, 83, 97, 102, 111, 132, 141, 155, 172, 190, 224], 'both': [8], 'cell': [9, 79, 109, 191, 198], 'types': [10], 'are': [11, 20, 128, 136, 179], 'identified': [12], 'as': [13], 'neural': [14, 48, 160, 206], 'stem': [15, 18, 49, 207], 'cells.': [16, 147, 228], 'Neural': [17], 'known': [21, 73, 99], 'to': [22, 39, 57], 'change': [23, 209], 'their': [24, 210], 'competency': [25], 'over': [26, 212], 'time': [27, 213], 'during': [28], 'development:': [29], 'they': [30], 'initially': [31, 124], 'undergo': [32], 'self-renewal': [33], 'only': [34], 'then': [36], 'give': [37], 'rise': [38], 'neurons': [40, 140], 'first': [41], 'later.': [45], 'Maintenance': [46], 'of': [47, 62, 78, 95, 105, 116, 145, 149, 158, 183, 186, 197], 'until': [51], 'late': [52], 'stages': [53], 'is': [54, 72, 81], 'thus': [55], 'believed': [56], 'be': [58], 'essential': [59, 180], 'for': [60, 181], 'generation': [61, 144, 182], 'in': [64, 118, 214], 'correct': [65], 'numbers': [66], 'diverse': [68], 'types,': [69], 'but': [70], 'little': [71], 'about': [74], 'how': [75, 84], 'the': [76, 153, 159, 162, 166, 169, 173, 195, 215], 'timing': [77, 196], 'differentiation': [80, 110], 'regulated': [82], 'its': [85], 'deregulation': [86], 'influences': [87], 'brain': [88, 119, 184], 'organogenesis.': [89], 'Here,': [90], 'we': [91], 'report': [92], 'that': [93, 204], 'inactivation': [94, 104], 'Hes1': [96], 'Hes5,': [98], 'Notch': [100], 'effectors,': [101], 'additional': [103], 'Hes3': [106], 'extensively': [107], 'accelerate': [108], 'cause': [112], 'a': [113], 'wide': [114], 'range': [115], 'defects': [117], 'formation.': [120], 'In': [121, 164], 'Hes-deficient': [122], 'embryos,': [123], 'formed': [125], 'not': [129], 'properly': [130], 'maintained,': [131], 'radial': [133, 150, 226], 'prematurely': [137], 'differentiated': [138], 'into': [139], 'depleted': [142], 'without': [143], 'late-born': [146], 'Furthermore,loss': [148], 'glia': [151], 'disrupts': [152], 'inner': [154], 'outer': [156], 'barriers': [157], 'tube,disorganizing': [161], 'histogenesis.': [163], 'addition,': [165], 'forebrain': [167], 'lacks': [168], 'optic': [170], 'vesicles': [171], 'ganglionic': [174], 'eminences.': [175], 'Thus,': [176], 'Hes': [177], 'genes': [178], 'structures': [185], 'appropriate': [187], 'size,': [188], 'shape': [189], 'arrangement': [192], 'by': [193], 'controlling': [194], 'differentiation.': [199], 'Our': [200], 'data': [201], 'also': [202], 'indicate': [203], 'embryonic': [205], 'characters': [211], 'following': [216], 'order:': [217], 'Hes-independent': [218], 'cells,transitory': [220], 'Hes-dependent': [221, 225]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2048389644', 'counts_by_year': [{'year': 2024, 'cited_by_count': 11}, {'year': 2023, 'cited_by_count': 20}, {'year': 2022, 'cited_by_count': 24}, {'year': 2021, 'cited_by_count': 25}, {'year': 2020, 'cited_by_count': 31}, {'year': 2019, 'cited_by_count': 24}, {'year': 2018, 'cited_by_count': 31}, {'year': 2017, 'cited_by_count': 20}, {'year': 2016, 'cited_by_count': 25}, {'year': 2015, 'cited_by_count': 19}, {'year': 2014, 'cited_by_count': 30}, {'year': 2013, 'cited_by_count': 36}, {'year': 2012, 'cited_by_count': 26}], 'updated_date': '2024-09-09T12:44:00.127721', 'created_date': '2016-06-24'}