Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2048255942', 'doi': 'https://doi.org/10.1111/j.1745-7254.2006.00247.x', 'title': 'Inhibition of Bcl-2 expression by a novel tumor-specific RNA interference system increases chemosensitivity to 5-fluorouracil in Hela cells', 'display_name': 'Inhibition of Bcl-2 expression by a novel tumor-specific RNA interference system increases chemosensitivity to 5-fluorouracil in Hela cells', 'publication_year': 2006, 'publication_date': '2006-01-23', 'ids': {'openalex': 'https://openalex.org/W2048255942', 'doi': 'https://doi.org/10.1111/j.1745-7254.2006.00247.x', 'mag': '2048255942', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/16412276'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.1745-7254.2006.00247.x', 'pdf_url': 'https://www.nature.com/articles/aps200629.pdf', 'source': {'id': 'https://openalex.org/S4210186974', 'display_name': 'Acta Pharmacologica Sinica', 'issn_l': '1671-4083', 'issn': ['1671-4083', '1745-7254'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.nature.com/articles/aps200629.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5067399305', 'display_name': 'Shenglin Huang', 'orcid': 'https://orcid.org/0000-0003-1279-0794'}, 'institutions': [{'id': 'https://openalex.org/I183067930', 'display_name': 'Shanghai Jiao Tong University', 'ror': 'https://ror.org/0220qvk04', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183067930']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Sheng-lin HUANG', 'raw_affiliation_strings': ['Research Center for Human Gene Therapy, Department of Biochemistry and Molecular Biology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.'], 'affiliations': [{'raw_affiliation_string': 'Research Center for Human Gene Therapy, Department of Biochemistry and Molecular Biology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.', 'institution_ids': ['https://openalex.org/I183067930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101591455', 'display_name': 'Yi Wu', 'orcid': 'https://orcid.org/0000-0003-2726-6135'}, 'institutions': [{'id': 'https://openalex.org/I183067930', 'display_name': 'Shanghai Jiao Tong University', 'ror': 'https://ror.org/0220qvk04', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183067930']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yi WU', 'raw_affiliation_strings': ['Research Center for Human Gene Therapy, Department of Biochemistry and Molecular Biology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.'], 'affiliations': [{'raw_affiliation_string': 'Research Center for Human Gene Therapy, Department of Biochemistry and Molecular Biology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.', 'institution_ids': ['https://openalex.org/I183067930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100423188', 'display_name': 'Haitao Yu', 'orcid': 'https://orcid.org/0000-0003-3116-0288'}, 'institutions': [{'id': 'https://openalex.org/I183067930', 'display_name': 'Shanghai Jiao Tong University', 'ror': 'https://ror.org/0220qvk04', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183067930']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Hai YU', 'raw_affiliation_strings': ['Research Center for Human Gene Therapy, Department of Biochemistry and Molecular Biology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.'], 'affiliations': [{'raw_affiliation_string': 'Research Center for Human Gene Therapy, Department of Biochemistry and Molecular Biology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.', 'institution_ids': ['https://openalex.org/I183067930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101659464', 'display_name': 'Ping Zhang', 'orcid': 'https://orcid.org/0000-0003-1428-692X'}, 'institutions': [{'id': 'https://openalex.org/I183067930', 'display_name': 'Shanghai Jiao Tong University', 'ror': 'https://ror.org/0220qvk04', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183067930']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ping ZHANG', 'raw_affiliation_strings': ['Research Center for Human Gene Therapy, Department of Biochemistry and Molecular Biology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.'], 'affiliations': [{'raw_affiliation_string': 'Research Center for Human Gene Therapy, Department of Biochemistry and Molecular Biology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.', 'institution_ids': ['https://openalex.org/I183067930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077242793', 'display_name': 'Xingqian Zhang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I183067930', 'display_name': 'Shanghai Jiao Tong University', 'ror': 'https://ror.org/0220qvk04', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183067930']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xing-qian ZHANG', 'raw_affiliation_strings': ['Research Center for Human Gene Therapy, Department of Biochemistry and Molecular Biology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.'], 'affiliations': [{'raw_affiliation_string': 'Research Center for Human Gene Therapy, Department of Biochemistry and Molecular Biology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.', 'institution_ids': ['https://openalex.org/I183067930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003449723', 'display_name': 'Ying Lei', 'orcid': 'https://orcid.org/0000-0001-5453-3070'}, 'institutions': [{'id': 'https://openalex.org/I183067930', 'display_name': 'Shanghai Jiao Tong University', 'ror': 'https://ror.org/0220qvk04', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183067930']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Lei YING', 'raw_affiliation_strings': ['Research Center for Human Gene Therapy, Department of Biochemistry and Molecular Biology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.'], 'affiliations': [{'raw_affiliation_string': 'Research Center for Human Gene Therapy, Department of Biochemistry and Molecular Biology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.', 'institution_ids': ['https://openalex.org/I183067930']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5042249499', 'display_name': 'Hongzheng Zhao', 'orcid': 'https://orcid.org/0000-0001-6618-3039'}, 'institutions': [{'id': 'https://openalex.org/I183067930', 'display_name': 'Shanghai Jiao Tong University', 'ror': 'https://ror.org/0220qvk04', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183067930']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Han-fang ZHAO', 'raw_affiliation_strings': ['Research Center for Human Gene Therapy, Department of Biochemistry and Molecular Biology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.'], 'affiliations': [{'raw_affiliation_string': 'Research Center for Human Gene Therapy, Department of Biochemistry and Molecular Biology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.', 'institution_ids': ['https://openalex.org/I183067930']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3290, 'currency': 'EUR', 'value_usd': 3990, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.41, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 26, 'citation_normalized_percentile': {'value': 0.689481, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 89, 'max': 90}, 'biblio': {'volume': '27', 'issue': '2', 'first_page': '242', 'last_page': '248'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10725', 'display_name': 'Mechanisms and Applications of RNA Interference', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10725', 'display_name': 'Mechanisms and Applications of RNA Interference', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10613', 'display_name': 'Gene Therapy Techniques and Applications', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10207', 'display_name': 'DNA Nanotechnology and Bioanalytical Applications', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/hela', 'display_name': 'HeLa', 'score': 0.6305703}, {'id': 'https://openalex.org/keywords/therapeutic-rnai', 'display_name': 'Therapeutic RNAi', 'score': 0.555682}, {'id': 'https://openalex.org/keywords/rna-interference', 'display_name': 'RNA Interference', 'score': 0.54389}, {'id': 'https://openalex.org/keywords/cancer-diagnostics', 'display_name': 'cancer diagnostics', 'score': 0.500507}, {'id': 'https://openalex.org/keywords/transcription', 'display_name': 'Transcription (linguistics)', 'score': 0.41195455}], 'concepts': [{'id': 'https://openalex.org/C125593758', 'wikidata': 'https://www.wikidata.org/wiki/Q15315135', 'display_name': 'Telomerase reverse transcriptase', 'level': 4, 'score': 0.776791}, {'id': 'https://openalex.org/C166703698', 'wikidata': 'https://www.wikidata.org/wiki/Q201993', 'display_name': 'RNA interference', 'level': 4, 'score': 0.75687313}, {'id': 'https://openalex.org/C190232843', 'wikidata': 'https://www.wikidata.org/wiki/Q1950808', 'display_name': 'Small hairpin RNA', 'level': 4, 'score': 0.69969445}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.6489916}, {'id': 'https://openalex.org/C2777366897', 'wikidata': 'https://www.wikidata.org/wiki/Q847482', 'display_name': 'HeLa', 'level': 3, 'score': 0.6305703}, {'id': 'https://openalex.org/C119056186', 'wikidata': 'https://www.wikidata.org/wiki/Q1431332', 'display_name': 'Gene silencing', 'level': 3, 'score': 0.6272596}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.50717974}, {'id': 'https://openalex.org/C111335760', 'wikidata': 'https://www.wikidata.org/wiki/Q95385166', 'display_name': 'Luciferase', 'level': 4, 'score': 0.4938813}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.4433121}, {'id': 'https://openalex.org/C62112901', 'wikidata': 'https://www.wikidata.org/wiki/Q189159', 'display_name': 'Cell growth', 'level': 2, 'score': 0.4376775}, {'id': 'https://openalex.org/C179926584', 'wikidata': 'https://www.wikidata.org/wiki/Q207714', 'display_name': 'Transcription (linguistics)', 'level': 2, 'score': 0.41195455}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.40821064}, {'id': 'https://openalex.org/C54009773', 'wikidata': 'https://www.wikidata.org/wiki/Q1429031', 'display_name': 'Transfection', 'level': 3, 'score': 0.39732558}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.33674482}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.31806242}, {'id': 'https://openalex.org/C67705224', 'wikidata': 'https://www.wikidata.org/wiki/Q11053', 'display_name': 'RNA', 'level': 3, 'score': 0.26954958}, {'id': 'https://openalex.org/C94581717', 'wikidata': 'https://www.wikidata.org/wiki/Q331839', 'display_name': 'Telomerase', 'level': 3, 'score': 0.25813857}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.20478216}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.11319733}, {'id': 'https://openalex.org/C41895202', 'wikidata': 'https://www.wikidata.org/wiki/Q8162', 'display_name': 'Linguistics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C138885662', 'wikidata': 'https://www.wikidata.org/wiki/Q5891', 'display_name': 'Philosophy', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D005472', 'descriptor_name': 'Fluorouracil', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D019253', 'descriptor_name': 'Proto-Oncogene Proteins c-bcl-2', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D034622', 'descriptor_name': 'RNA Interference', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D019098', 'descriptor_name': 'Telomerase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D002453', 'descriptor_name': 'Cell Cycle', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005472', 'descriptor_name': 'Fluorouracil', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005822', 'descriptor_name': 'Genetic Vectors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006367', 'descriptor_name': 'HeLa Cells', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D006367', 'descriptor_name': 'HeLa Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008113', 'descriptor_name': 'Liver Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D008113', 'descriptor_name': 'Liver Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011401', 'descriptor_name': 'Promoter Regions, Genetic', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011401', 'descriptor_name': 'Promoter Regions, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019253', 'descriptor_name': 'Proto-Oncogene Proteins c-bcl-2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019098', 'descriptor_name': 'Telomerase', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D019098', 'descriptor_name': 'Telomerase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.1745-7254.2006.00247.x', 'pdf_url': 'https://www.nature.com/articles/aps200629.pdf', 'source': {'id': 'https://openalex.org/S4210186974', 'display_name': 'Acta Pharmacologica Sinica', 'issn_l': '1671-4083', 'issn': ['1671-4083', '1745-7254'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16412276', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.1745-7254.2006.00247.x', 'pdf_url': 'https://www.nature.com/articles/aps200629.pdf', 'source': {'id': 'https://openalex.org/S4210186974', 'display_name': 'Acta Pharmacologica Sinica', 'issn_l': '1671-4083', 'issn': ['1671-4083', '1745-7254'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.52}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 27, 'referenced_works': ['https://openalex.org/W1611419331', 'https://openalex.org/W1931443173', 'https://openalex.org/W1966386214', 'https://openalex.org/W1991584312', 'https://openalex.org/W1991778767', 'https://openalex.org/W2003335102', 'https://openalex.org/W2008135314', 'https://openalex.org/W2028254635', 'https://openalex.org/W2038783205', 'https://openalex.org/W2052312685', 'https://openalex.org/W2061548598', 'https://openalex.org/W2072543946', 'https://openalex.org/W2092930138', 'https://openalex.org/W2094980048', 'https://openalex.org/W2103392842', 'https://openalex.org/W2111254733', 'https://openalex.org/W2126627612', 'https://openalex.org/W2126975650', 'https://openalex.org/W2132411546', 'https://openalex.org/W2133779118', 'https://openalex.org/W2134270780', 'https://openalex.org/W2146900615', 'https://openalex.org/W2156876150', 'https://openalex.org/W2158943854', 'https://openalex.org/W2160062417', 'https://openalex.org/W2171342364', 'https://openalex.org/W2321374471'], 'related_works': ['https://openalex.org/W3150194181', 'https://openalex.org/W3148023678', 'https://openalex.org/W3140082918', 'https://openalex.org/W2424028002', 'https://openalex.org/W2387605231', 'https://openalex.org/W2375116590', 'https://openalex.org/W2357247218', 'https://openalex.org/W2356627213', 'https://openalex.org/W2349566129', 'https://openalex.org/W2003755164'], 'abstract_inverted_index': {'RNA': [0, 71], 'interference': [1], '(RNAi)': [2], 'has': [3, 28], 'been': [4], 'proposed': [5], 'as': [6], 'a': [7, 44, 68], 'potential': [8], 'treatment': [9], 'for': [10, 215, 245], 'cancer,': [11], 'but': [12, 171, 198], 'the': [13, 37, 49, 144, 153, 162, 186, 200, 225], 'lack': [14], 'of': [15, 118, 161, 188, 191, 202, 229], 'cellular': [16], 'targets': [17], 'limits': [18], 'its': [19, 59], 'use': [20], 'in': [21, 168, 178], 'cancer': [22], 'gene': [23, 32, 87, 216], 'therapy.': [24, 247], 'No': [25], 'current': [26], 'technology': [27], 'achieved': [29], 'direct': [30], 'tumor-specific': [31, 45], 'silencing': [33, 217], 'using': [34, 48, 134, 224, 232], 'RNAi.': [35], 'In': [36], 'present': [38, 208], 'study': [39, 209], 'we': [40, 57], 'attempt': [41], 'to': [42, 73, 113, 142, 205, 221, 238], 'develop': [43], 'RNAi': [46, 213, 246], 'system': [47, 214, 234, 241], 'human': [50], 'telomerase': [51], 'reverse': [52], 'transcriptase': [53], '(hTERT)': [54], 'promoter;': [55], 'furthermore,': [56], 'analyzed': [58], 'inhibitive': [60], 'effect': [61], 'on': [62], 'Bcl-2': [63, 119, 192, 230], 'expression.': [64, 116], 'The': [65, 180, 207], 'vectors': [66], 'containing': [67], 'small': [69], 'hairpin': [70], '(shRNA)': [72], 'target': [74], 'exogenous': [75, 163], 'reporters': [76, 164], '[firefly': [77], 'luciferase': [78, 97], 'and': [79, 85, 106, 124, 129, 166], 'enhanced': [80], 'green': [81], 'fluorescent': [82], 'protein': [83], '(EGFP)]': [84], 'endogenous': [86], '(Bcl-2)': [88], 'were': [89, 111, 131], 'constructed.': [90], 'Luciferase': [91], 'expression': [92, 160, 187], 'was': [93, 120, 140, 175], 'determined': [94], 'by': [95, 122, 133, 231], 'dual': [96], 'assay.': [98, 138], 'Reverse': [99], 'transcription-polymerase': [100], 'chain': [101], 'reaction': [102], '(RT-PCR),': [103], 'fluorescence': [104], 'microscopy': [105], 'fluorescence-activated': [107], 'cell': [108, 145, 196], 'sorting': [109], '(FACS)': [110], 'used': [112, 141], 'measure': [114], 'EGFP': [115], 'Inhibition': [117, 190], 'evaluated': [121], 'RT-PCR': [123], 'Western': [125], 'blotting.': [126], 'Cell': [127], 'proliferation': [128], 'viability': [130], 'measured': [132], '3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium': [135], 'bromide': [136], '(MTT)': [137], 'FACS': [139], 'analyze': [143], 'cycle': [146], 'distribution': [147], 'profile.': [148], 'We': [149], 'showed': [150], 'that': [151, 218], 'with': [152], 'hTERT': [154, 181, 226], 'promoter': [155], 'directly': [156], 'driving': [157], 'shRNA': [158, 183], 'transcription,': [159], '(LUC': [165], 'EGFP)': [167], 'tumor': [169, 222], 'cells,': [170, 174], 'not': [172, 194], 'normal': [173], 'specifically': [176], 'inhibited': [177], 'vitro.': [179], 'promoter-driven': [182], 'also': [184], 'depressed': [185], 'Bcl-2.': [189], 'did': [193], 'affect': [195], 'proliferation,': [197], 'increased': [199], 'chemosensitivity': [201], 'HeLa': [203, 236], 'cells': [204, 223, 237], '5-fluorouracil.': [206], 'describes': [210], 'an': [211], 'efficient': [212], 'is': [219], 'specific': [220], 'promoter.': [227], 'Suppression': [228], 'this': [233], 'sensitized': [235], '5–fluorouracil.': [239], 'This': [240], 'may': [242], 'be': [243], 'useful': [244]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2048255942', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-09-17T06:16:14.589213', 'created_date': '2016-06-24'}