Protection of Rpe65-deficient mice identifies rhodopsin as a mediator of light-induced retinal degeneration

Name: Work Video:
Duration: 3 min 30 s
Christian Grimm; Andreas Wenzel; Farhad Hafezi; Shirley Yu; T. Michael Redmond; Charlotte E. Remé
{'id': 'https://openalex.org/W2048058414', 'doi': 'https://doi.org/10.1038/75614', 'title': 'Protection of Rpe65-deficient mice identifies rhodopsin as a mediator of light-induced retinal degeneration', 'display_name': 'Protection of Rpe65-deficient mice identifies rhodopsin as a mediator of light-induced retinal degeneration', 'publication_year': 2000, 'publication_date': '2000-05-01', 'ids': {'openalex': 'https://openalex.org/W2048058414', 'doi': 'https://doi.org/10.1038/75614', 'mag': '2048058414', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/10802658'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1038/75614', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S137905309', 'display_name': 'Nature Genetics', 'issn_l': '1061-4036', 'issn': ['1061-4036', '1546-1718'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5004628461', 'display_name': 'Christian Grimm', 'orcid': 'https://orcid.org/0000-0001-9318-4352'}, 'institutions': [{'id': 'https://openalex.org/I202697423', 'display_name': 'University of Zurich', 'ror': 'https://ror.org/02crff812', 'country_code': 'CH', 'type': 'education', 'lineage': ['https://openalex.org/I202697423']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Christian Grimm', 'raw_affiliation_strings': ['Laboratory of Retinal Cell Biology, Department of Ophthalmology, University Hospital Zurich, Zurich, Switzerland.'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Retinal Cell Biology, Department of Ophthalmology, University Hospital Zurich, Zurich, Switzerland.', 'institution_ids': ['https://openalex.org/I202697423']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5078745000', 'display_name': 'Andreas Wenzel', 'orcid': 'https://orcid.org/0000-0002-2758-9842'}, 'institutions': [{'id': 'https://openalex.org/I202697423', 'display_name': 'University of Zurich', 'ror': 'https://ror.org/02crff812', 'country_code': 'CH', 'type': 'education', 'lineage': ['https://openalex.org/I202697423']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Andreas Wenzel', 'raw_affiliation_strings': ['Department of Ophthalmology, Laboratory of Retinal Cell Biology, University Hospital Zurich, Zurich'], 'affiliations': [{'raw_affiliation_string': 'Department of Ophthalmology, Laboratory of Retinal Cell Biology, University Hospital Zurich, Zurich', 'institution_ids': ['https://openalex.org/I202697423']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003253011', 'display_name': 'Farhad Hafezi', 'orcid': 'https://orcid.org/0000-0001-8935-4558'}, 'institutions': [{'id': 'https://openalex.org/I202697423', 'display_name': 'University of Zurich', 'ror': 'https://ror.org/02crff812', 'country_code': 'CH', 'type': 'education', 'lineage': ['https://openalex.org/I202697423']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Farhad Hafezi', 'raw_affiliation_strings': ['Department of Ophthalmology, Laboratory of Retinal Cell Biology, University Hospital Zurich, Zurich'], 'affiliations': [{'raw_affiliation_string': 'Department of Ophthalmology, Laboratory of Retinal Cell Biology, University Hospital Zurich, Zurich', 'institution_ids': ['https://openalex.org/I202697423']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113174324', 'display_name': 'Shirley Yu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210139686', 'display_name': 'National Eye Institute', 'ror': 'https://ror.org/03wkg3b53', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210139686']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Shirley Yu', 'raw_affiliation_strings': ['Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, NIH, Bethesda, USA'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, NIH, Bethesda, USA', 'institution_ids': ['https://openalex.org/I4210139686']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037182958', 'display_name': 'T. Michael Redmond', 'orcid': 'https://orcid.org/0000-0002-1813-5291'}, 'institutions': [{'id': 'https://openalex.org/I4210139686', 'display_name': 'National Eye Institute', 'ror': 'https://ror.org/03wkg3b53', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210139686']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'T. Michael Redmond', 'raw_affiliation_strings': ['Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, NIH, Bethesda, USA'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, NIH, Bethesda, USA', 'institution_ids': ['https://openalex.org/I4210139686']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5111576513', 'display_name': 'Charlotte E. Remé', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I202697423', 'display_name': 'University of Zurich', 'ror': 'https://ror.org/02crff812', 'country_code': 'CH', 'type': 'education', 'lineage': ['https://openalex.org/I202697423']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Charlotte E. Remé', 'raw_affiliation_strings': ['Department of Ophthalmology, Laboratory of Retinal Cell Biology, University Hospital Zurich, Zurich'], 'affiliations': [{'raw_affiliation_string': 'Department of Ophthalmology, Laboratory of Retinal Cell Biology, University Hospital Zurich, Zurich', 'institution_ids': ['https://openalex.org/I202697423']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 9750, 'currency': 'EUR', 'value_usd': 11690, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 6.26, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 273, 'citation_normalized_percentile': {'value': 0.999974, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '25', 'issue': '1', 'first_page': '63', 'last_page': '66'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10691', 'display_name': 'Retinal Development and Disorders', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10691', 'display_name': 'Retinal Development and Disorders', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10170', 'display_name': 'Retinal Diseases and Treatments', 'score': 0.9978, 'subfield': {'id': 'https://openalex.org/subfields/2731', 'display_name': 'Ophthalmology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12236', 'display_name': 'Photoreceptor and optogenetics research', 'score': 0.9976, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/rpe65', 'display_name': 'RPE65', 'score': 0.8738173}, {'id': 'https://openalex.org/keywords/opsin', 'display_name': 'Opsin', 'score': 0.8514534}, {'id': 'https://openalex.org/keywords/visual-phototransduction', 'display_name': 'Visual phototransduction', 'score': 0.7679019}, {'id': 'https://openalex.org/keywords/cis-trans-isomerases', 'display_name': 'Cis-trans-Isomerases', 'score': 0.48592868}], 'concepts': [{'id': 'https://openalex.org/C202033177', 'wikidata': 'https://www.wikidata.org/wiki/Q423107', 'display_name': 'Rhodopsin', 'level': 3, 'score': 0.9489717}, {'id': 'https://openalex.org/C2780724529', 'wikidata': 'https://www.wikidata.org/wiki/Q18031223', 'display_name': 'RPE65', 'level': 4, 'score': 0.8738173}, {'id': 'https://openalex.org/C30028475', 'wikidata': 'https://www.wikidata.org/wiki/Q24785022', 'display_name': 'Opsin', 'level': 4, 'score': 0.8514534}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.80359983}, {'id': 'https://openalex.org/C131667965', 'wikidata': 'https://www.wikidata.org/wiki/Q445081', 'display_name': 'Visual phototransduction', 'level': 3, 'score': 0.7679019}, {'id': 'https://openalex.org/C2781114197', 'wikidata': 'https://www.wikidata.org/wiki/Q847057', 'display_name': 'Retinitis pigmentosa', 'level': 3, 'score': 0.6804485}, {'id': 'https://openalex.org/C2781040256', 'wikidata': 'https://www.wikidata.org/wiki/Q7316761', 'display_name': 'Retinal degeneration', 'level': 3, 'score': 0.6162845}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.6051022}, {'id': 'https://openalex.org/C2780827179', 'wikidata': 'https://www.wikidata.org/wiki/Q422001', 'display_name': 'Retinal', 'level': 2, 'score': 0.54222375}, {'id': 'https://openalex.org/C2910190745', 'wikidata': 'https://www.wikidata.org/wiki/Q5122112', 'display_name': 'Cis-trans-Isomerases', 'level': 5, 'score': 0.48592868}, {'id': 'https://openalex.org/C47870650', 'wikidata': 'https://www.wikidata.org/wiki/Q4682229', 'display_name': 'Gene therapy of the human retina', 'level': 4, 'score': 0.45864493}, {'id': 'https://openalex.org/C2778024200', 'wikidata': 'https://www.wikidata.org/wiki/Q2346242', 'display_name': 'Retinal pigment epithelium', 'level': 3, 'score': 0.38085654}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.250439}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.18767872}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.12252721}, {'id': 'https://openalex.org/C2910677434', 'wikidata': 'https://www.wikidata.org/wiki/Q426411', 'display_name': 'Peptidylprolyl isomerase', 'level': 4, 'score': 0.0}, {'id': 'https://openalex.org/C2781264208', 'wikidata': 'https://www.wikidata.org/wiki/Q118026', 'display_name': 'Isomerase', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D008027', 'descriptor_name': 'Light', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': True}, {'descriptor_ui': 'D010857', 'descriptor_name': 'Pigment Epithelium of Eye', 'qualifier_ui': 'Q000528', 'qualifier_name': 'radiation effects', 'is_major_topic': True}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D012162', 'descriptor_name': 'Retinal Degeneration', 'qualifier_ui': 'Q000209', 'qualifier_name': 'etiology', 'is_major_topic': True}, {'descriptor_ui': 'D012243', 'descriptor_name': 'Rhodopsin', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000528', 'qualifier_name': 'radiation effects', 'is_major_topic': False}, {'descriptor_ui': 'D002352', 'descriptor_name': 'Carrier Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005136', 'descriptor_name': 'Eye Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008027', 'descriptor_name': 'Light', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018345', 'descriptor_name': 'Mice, Knockout', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020419', 'descriptor_name': 'Photoreceptor Cells, Vertebrate', 'qualifier_ui': 'Q000528', 'qualifier_name': 'radiation effects', 'is_major_topic': False}, {'descriptor_ui': 'D020419', 'descriptor_name': 'Photoreceptor Cells, Vertebrate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020419', 'descriptor_name': 'Photoreceptor Cells, Vertebrate', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D010857', 'descriptor_name': 'Pigment Epithelium of Eye', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012162', 'descriptor_name': 'Retinal Degeneration', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012162', 'descriptor_name': 'Retinal Degeneration', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D012243', 'descriptor_name': 'Rhodopsin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012243', 'descriptor_name': 'Rhodopsin', 'qualifier_ui': 'Q000172', 'qualifier_name': 'deficiency', 'is_major_topic': False}, {'descriptor_ui': 'D012243', 'descriptor_name': 'Rhodopsin', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D018808', 'descriptor_name': 'Transcription Factor AP-1', 'qualifier_ui': 'Q000528', 'qualifier_name': 'radiation effects', 'is_major_topic': False}, {'descriptor_ui': 'D018808', 'descriptor_name': 'Transcription Factor AP-1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019745', 'descriptor_name': 'cis-trans-Isomerases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1038/75614', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S137905309', 'display_name': 'Nature Genetics', 'issn_l': '1061-4036', 'issn': ['1061-4036', '1546-1718'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/10802658', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.5, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 31, 'referenced_works': ['https://openalex.org/W1481967758', 'https://openalex.org/W1561981443', 'https://openalex.org/W1587435244', 'https://openalex.org/W164426026', 'https://openalex.org/W1712412471', 'https://openalex.org/W1803429836', 'https://openalex.org/W1906993142', 'https://openalex.org/W1967425877', 'https://openalex.org/W1974761228', 'https://openalex.org/W1994172606', 'https://openalex.org/W1998393168', 'https://openalex.org/W1999179844', 'https://openalex.org/W2007338505', 'https://openalex.org/W2027716003', 'https://openalex.org/W2030452669', 'https://openalex.org/W2042446342', 'https://openalex.org/W2054775209', 'https://openalex.org/W2055229720', 'https://openalex.org/W2063635108', 'https://openalex.org/W2063658617', 'https://openalex.org/W2064261105', 'https://openalex.org/W2068287207', 'https://openalex.org/W2078966528', 'https://openalex.org/W2079178498', 'https://openalex.org/W2103495778', 'https://openalex.org/W2119818353', 'https://openalex.org/W2155349225', 'https://openalex.org/W4240235259', 'https://openalex.org/W4300796354', 'https://openalex.org/W61809690', 'https://openalex.org/W88214990'], 'related_works': ['https://openalex.org/W2156859668', 'https://openalex.org/W2145759960', 'https://openalex.org/W2119068128', 'https://openalex.org/W2105803232', 'https://openalex.org/W2088596647', 'https://openalex.org/W2062618306', 'https://openalex.org/W2051231096', 'https://openalex.org/W1972258703', 'https://openalex.org/W1587435244', 'https://openalex.org/W1198191156'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2048058414', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 11}, {'year': 2022, 'cited_by_count': 7}, {'year': 2021, 'cited_by_count': 10}, {'year': 2020, 'cited_by_count': 8}, {'year': 2019, 'cited_by_count': 10}, {'year': 2018, 'cited_by_count': 9}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 12}, {'year': 2014, 'cited_by_count': 9}, {'year': 2013, 'cited_by_count': 13}, {'year': 2012, 'cited_by_count': 25}], 'updated_date': '2024-12-12T22:21:13.020309', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
