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'https://openalex.org/W1996686686', 'https://openalex.org/W1985967033'], 'abstract_inverted_index': {'Surfactant': [0, 250, 500], 'protein': [1, 132, 165, 251, 382, 415, 501, 510, 1970, 2499, 2510, 2952, 3022, 3053, 3726, 3797, 3859, 3881, 4057, 4162, 4327, 4347, 4444, 4958, 5017, 5038, 5100, 5112, 5281, 5501, 5712], 'B': [2, 252, 502], '(SP-B)': [3, 253, 503], 'is': [4, 12, 254, 262, 528, 685, 823, 846, 1027, 1066, 1296, 3622, 3828, 3834, 4199, 4208, 4511, 4519, 4666, 4692, 4707, 4759, 4813, 5157, 5162, 5757, 5818, 5850, 5902, 5925, 5947, 6208, 6213, 6240, 6249, 6321], 'an': [5, 53, 255, 303, 1089, 1514, 1580, 2016, 2939, 3309, 3389, 3519, 3532, 3558, 3649, 3822, 4985, 5035, 5296, 5871], 'essential': [6, 256, 6322], 'constituent': [7, 257], 'of': [8, 31, 73, 80, 93, 102, 121, 145, 149, 170, 174, 207, 217, 244, 258, 281, 323, 330, 343, 352, 371, 395, 399, 420, 424, 457, 467, 494, 542, 583, 596, 615, 777, 868, 918, 932, 942, 1033, 1078, 1137, 1429, 1441, 1445, 1455, 1503, 1510, 1519, 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6413, 6423], 'pulmonary': [9, 259, 1300], 'surfactant.': [10, 260], 'SP-B': [11, 81, 94, 103, 192, 219, 248, 261, 331, 344, 353, 442, 469, 498, 577, 598, 674, 766, 778, 822, 845, 1456, 1505, 1515, 1587, 1604, 1650, 2230, 2455, 2471, 2652, 2664, 3078, 3268, 3284, 3302, 3315, 3341, 3406, 3418, 3655, 3679, 3704, 3752, 3820, 3915, 4004, 4011, 4024, 4108, 4234, 4261, 4357, 4415, 4457, 4472, 4672, 4702, 4764, 4770, 4980, 5381, 5500, 5548, 5691, 5781, 5809, 5862, 5945, 5964, 6168, 6217, 6313, 6369], 'synthesized': [13, 263, 847, 2521, 2760, 2806, 2853, 2898, 4131, 4306], 'in': [14, 48, 57, 64, 97, 118, 159, 214, 223, 242, 264, 298, 307, 314, 347, 368, 409, 464, 473, 492, 538, 600, 603, 676, 768, 774, 782, 862, 879, 940, 1039, 1130, 1293, 1299, 1528, 1583, 1597, 1807, 1976, 2011, 2094, 2155, 2255, 2308, 2368, 2387, 2422, 2525, 2543, 2556, 2924, 2930, 2953, 2965, 3017, 3082, 3190, 3203, 3218, 3251, 3279, 3356, 3391, 3398, 3490, 3524, 3550, 3617, 3711, 3721, 3735, 3770, 3835, 3865, 4037, 4058, 4078, 4210, 4232, 4250, 4269, 4345, 4353, 4360, 4412, 4450, 4480, 4513, 4589, 4668, 4687, 4815, 4869, 4881, 4899, 4936, 4951, 5018, 5031, 5034, 5050, 5146, 5173, 5277, 5392, 5396, 5402, 5486, 5511, 5543, 5690, 5750, 5759, 5769, 5795, 5820, 5876, 5889, 5896, 5938, 6061, 6084, 6156, 6216, 6219, 6308, 6333, 6340, 6375], 'alveolar': [15, 58, 265, 308, 540, 591, 784, 852, 3221], 'type': [16, 59, 98, 106, 224, 266, 309, 348, 356, 474, 853, 880, 920, 1127, 1289, 1763, 2860, 3003, 3045, 3140, 3252, 3287, 4275, 4292, 4311, 4361, 4481, 4585, 4776, 5174, 5592, 5893], 'II': [17, 60, 99, 107, 225, 267, 310, 349, 357, 475, 854, 881, 921, 1128, 1290, 1656, 1764, 2861, 3004, 3046, 3141, 3288, 4252, 4276, 4293, 4312, 4362, 4482, 4586, 4777, 5175, 5593, 5894], 'cells': [18, 108, 116, 268, 358, 366, 856, 861, 882, 1129, 1136, 1657, 1894, 1897, 2118, 2126, 2258, 2292, 2325, 2862, 2955, 2967, 3005, 3047, 3121, 3142, 3255, 3290, 3332, 3334, 3371, 3387, 3526, 4277, 4294, 4363, 4588, 5594, 5895], 'as': [19, 68, 70, 269, 318, 320, 848, 1272, 1284, 1664, 1821, 1862, 1928, 1973, 2259, 2333, 2415, 2439, 2522, 2783, 2820, 2870, 3064, 3066, 3225, 3359, 3361, 3718, 3743, 3745, 4054, 4157, 4680, 4682, 4959, 5012, 5097, 5715, 6146, 6149], 'a': [20, 49, 110, 122, 128, 154, 270, 299, 360, 372, 378, 404, 529, 584, 775, 849, 1114, 1438, 1494, 2049, 2073, 2237, 2300, 2440, 2847, 2925, 2949, 3041, 3324, 3347, 3603, 3774, 3831, 4055, 4188, 4351, 4409, 4507, 4520, 4525, 4711, 4783, 4972, 5005, 5013, 5098, 5180, 5195, 5377, 5675, 6150, 6241], 'preproprotein': [21, 271, 850], 'and': [22, 33, 83, 139, 193, 197, 220, 234, 272, 283, 333, 389, 443, 447, 470, 484, 581, 607, 830, 857, 935, 1068, 1073, 1133, 1507, 1531, 1644, 1690, 1695, 1759, 1776, 1854, 1955, 1969, 2002, 2045, 2087, 2089, 2132, 2176, 2203, 2220, 2242, 2306, 2424, 2428, 2451, 2462, 2473, 2481, 2498, 2600, 2609, 2630, 2660, 2684, 2721, 2734, 2793, 2917, 2933, 2997, 3080, 3124, 3180, 3264, 3271, 3306, 3346, 3369, 3397, 3527, 3583, 3589, 3657, 3673, 3739, 3800, 3884, 3909, 3968, 3994, 4025, 4033, 4092, 4149, 4177, 4179, 4185, 4187, 4193, 4217, 4227, 4247, 4307, 4390, 4459, 4581, 4704, 4829, 4981, 5083, 5101, 5121, 5257, 5269, 5390, 5400, 5588, 5673, 5683, 5731, 5754, 5790, 5810, 6161, 6169, 6254, 6326, 6370, 6408, 6417], 'processed': [23, 273, 1962, 3377, 4892, 5927], 'to': [24, 42, 88, 274, 292, 338, 610, 680, 788, 871, 923, 1085, 1122, 1126, 1271, 1283, 1433, 1637, 1647, 1858, 1925, 2030, 2105, 2582, 2588, 2611, 2632, 2769, 2855, 2978, 3050, 3074, 3149, 3156, 3424, 3601, 3624, 3707, 3956, 3997, 4072, 4101, 4201, 4324, 4330, 4417, 4446, 4577, 4755, 4889, 4893, 5041, 5092, 5150, 5254, 5503, 5524, 5540, 5582, 5585, 5697, 5752, 5771, 5846, 5911, 6082, 6138, 6142, 6158, 6199], 'the': [25, 29, 44, 78, 91, 134, 146, 171, 181, 188, 194, 203, 245, 275, 279, 294, 328, 341, 384, 396, 421, 431, 438, 444, 453, 495, 539, 543, 579, 590, 597, 769, 783, 863, 869, 872, 915, 919, 924, 933, 943, 1034, 1040, 1079, 1131, 1138, 1442, 1452, 1520, 1586, 1598, 1601, 1640, 1649, 1704, 1800, 1901, 1911, 1918, 2076, 2138, 2204, 2228, 2319, 2360, 2449, 2469, 2479, 2487, 2496, 2535, 2607, 2650, 2658, 2689, 2747, 2762, 2770, 2777, 2814, 2856, 2958, 2972, 2983, 2993, 3052, 3075, 3134, 3144, 3157, 3199, 3209, 3262, 3283, 3313, 3338, 3378, 3382, 3392, 3405, 3429, 3486, 3491, 3494, 3500, 3510, 3551, 3618, 3627, 3653, 3664, 3678, 3683, 3687, 3699, 3728, 3732, 3736, 3740, 3746, 3771, 3786, 3794, 3807, 3811, 3839, 3842, 3868, 3879, 3891, 3895, 3905, 3910, 3920, 3924, 3969, 3999, 4003, 4016, 4022, 4026, 4030, 4034, 4038, 4042, 4068, 4081, 4099, 4103, 4107, 4127, 4138, 4141, 4202, 4211, 4215, 4260, 4270, 4331, 4354, 4391, 4414, 4418, 4454, 4460, 4477, 4514, 4571, 4578, 4662, 4671, 4688, 4695, 4763, 4767, 4773, 4796, 4804, 4816, 4850, 4870, 4874, 4894, 4943, 4947, 4952, 4956, 4989, 4998, 5002, 5026, 5042, 5047, 5051, 5076, 5080, 5084, 5125, 5128, 5134, 5142, 5147, 5151, 5154, 5165, 5170, 5250, 5278, 5308, 5318, 5393, 5397, 5403, 5408, 5411, 5417, 5425, 5429, 5483, 5492, 5525, 5544, 5686, 5706, 5718, 5726, 5735, 5762, 5777, 5801, 5805, 5811, 5821, 5825, 5834, 5853, 5866, 5877, 5883, 5923, 5939, 6078, 6085, 6143, 6221, 6228, 6233, 6310, 6329, 6335, 6341, 6364, 6378, 6383, 6389, 6393, 6420], 'mature': [26, 150, 175, 191, 218, 221, 276, 400, 425, 441, 468, 471, 875, 944, 1504, 2651, 2690, 3314, 3407, 3654, 3665, 3688, 3741, 3751, 3812, 3819, 3896, 3914, 3925, 4005, 4023, 4031, 4109, 4358, 4373, 4421, 4463, 4897, 4979, 4990, 5085, 5398, 5426, 5484, 5766, 5808, 5861, 5936, 5956, 5963, 6167, 6170, 6234, 6314, 6368], 'peptide': [27, 196, 277, 446, 533, 876, 937, 945, 1506, 2692, 3316, 3408, 3604, 3666, 3742, 3775, 3788, 3897, 3971, 4006, 4032, 4110, 4359, 4374, 4464, 4898, 4973, 5009, 5077, 5086, 5405, 5427, 5485, 5779, 6235, 6396], 'by': [28, 209, 278, 459, 780, 851, 1088, 1436, 1526, 1797, 1817, 1889, 1915, 2099, 2142, 2218, 2252, 2261, 2326, 2426, 2434, 2443, 2466, 2503, 2513, 2585, 2739, 2751, 2807, 2989, 3114, 3269, 3426, 3529, 3581, 3591, 3648, 3930, 3951, 3954, 3975, 4165, 4265, 4350, 4853, 4865, 4984, 5107, 5115, 5434, 5788, 5865, 5914], 'cleavage': [30, 280, 931, 1074, 1077, 3586, 3700, 3844, 3866, 3907, 4079, 4230, 4848, 4864, 5130, 5144, 5370, 5384, 5481, 5507, 5694, 5721, 5786, 5802, 6226], 'NH2-': [32, 282, 934, 2659, 3263, 4216], 'COOH-terminal': [34, 182, 195, 204, 284, 432, 445, 454, 936, 2239, 2661, 3265, 3504, 4039, 4128, 4142, 4218, 5155, 5309, 5404, 5430, 5778, 5812, 5826, 5836], 'peptides.': [35, 285], 'An': [36, 286, 4010], 'aspartyl': [37, 54, 287, 304, 1090, 1111, 4522, 6330], 'protease': [38, 55, 156, 288, 305, 406, 1091, 1112, 4523, 6331], 'has': [39, 289, 4098], 'been': [40, 290, 5491, 5909], 'suggested': [41, 291, 5433, 5539], 'cleave': [43, 180, 293, 430, 4122, 5305, 5423, 5705], 'NH2-terminal': [45, 135, 295, 385, 1080, 3430, 3495, 3737, 3823, 4203, 4999, 5148, 5418, 5707, 5727], 'propeptide': [46, 136, 296, 386, 1081, 1602, 3431, 3680, 3738, 5052, 5149, 5419], 'resulting': [47, 297], '25-kDa': [50, 123, 300, 373, 4797, 4851, 5171, 6336], 'intermediate.': [51, 124, 301, 374, 4820], 'Napsin,': [52, 302], 'expressed': [56, 306, 1500, 3523, 4045, 4053, 4156, 4935, 5096, 6155], 'cells,': [61, 311, 3128, 3206, 4809, 4938], 'was': [62, 86, 312, 336, 1082, 1119, 1431, 1524, 1532, 1594, 1634, 1693, 1770, 1795, 1842, 1887, 1913, 2009, 2025, 2079, 2113, 2190, 2206, 2233, 2250, 2316, 2355, 2410, 2432, 2493, 2501, 2511, 2530, 2594, 2637, 2737, 2749, 2805, 2852, 2900, 2910, 2986, 3013, 3023, 3048, 3112, 3147, 3186, 3194, 3215, 3248, 3277, 3304, 3421, 3507, 3522, 3538, 3579, 3587, 3693, 3934, 3962, 3973, 4007, 4044, 4052, 4163, 4181, 4263, 4348, 4375, 4379, 4398, 4678, 4780, 4879, 4886, 4940, 4975, 4982, 5010, 5090, 5095, 5102, 5113, 5374, 5385, 5538, 5580, 5713, 5723, 5804, 5844, 5886], 'detected': [63, 313, 2948, 2988, 3024, 3062, 3217, 3250, 3355, 3647, 4679, 4715, 4983, 5368, 5386, 5724, 5888], 'fetal': [65, 315, 3059, 3083, 4689], 'lung': [66, 316, 544, 771, 828, 1132, 1954, 2996, 3060, 3084, 5919], 'homogenates': [67, 317, 2999, 3061], 'early': [69, 319, 3065, 4681, 6421], 'day': [71, 76, 321, 326, 3067, 3072, 4683, 4722, 4728], '16': [72, 322, 3068, 4684, 4729], 'gestation,': [74, 324, 3070], '1': [75, 325, 2163, 2394, 2504, 2563, 3028, 3071], 'before': [77, 327], 'onset': [79, 329, 3076, 4698], 'expression': [82, 332, 1117, 1295, 1428, 1454, 1518, 2139, 3079, 4268, 4530, 4677, 4703, 4717, 5027, 5946, 6182], 'processing.': [84, 334, 4705], 'Napsin': [85, 177, 335, 427, 1654, 2219, 2427, 2928, 2985, 3214, 3247, 3270, 4246, 4518, 5301], 'localized': [87, 337, 1124, 3148, 4575, 5584], 'multivesicular': [89, 339, 925, 3181, 3191, 4582, 5589], 'bodies,': [90, 340, 5587], 'site': [92, 342, 3908, 5145, 5722], 'proprotein': [95, 104, 345, 354, 912, 1035, 2231, 3303, 4262, 4416, 4771, 5728, 5885, 5924], 'processing': [96, 346, 867, 1032, 1065, 1516, 1584, 1599, 3081, 3281, 3349, 3395, 3419, 3492, 4198, 4212, 4258, 4413, 4458, 4515, 4669, 5549, 5827, 5855, 5878, 5950, 6063, 6218, 6244, 6325, 6376], 'cells.': [100, 226, 350, 476, 1783, 3259, 3515, 4313, 4484, 4792, 4842, 4884, 5176], 'Incubation': [101, 351, 3755, 4060, 4963], 'from': [105, 114, 355, 364, 1660, 1762, 1958, 2081, 2318, 2359, 2468, 2534, 2606, 2865, 3007, 3040, 3329, 3367, 3385, 3509, 3806, 3848, 4593, 4772, 4787, 4807, 4840, 4847, 5104, 5317, 5960, 6251], 'with': [109, 359, 535, 689, 1113, 1287, 1513, 1534, 1786, 1803, 1900, 1921, 1966, 2022, 2095, 2129, 2144, 2192, 2208, 2236, 2295, 2357, 2381, 2476, 2495, 2532, 2553, 2596, 2639, 2713, 2723, 2761, 2902, 2913, 2938, 2957, 2974, 3025, 3133, 3208, 3293, 3308, 3323, 3337, 3364, 3404, 3518, 3540, 3564, 3607, 3632, 3640, 3759, 3776, 3821, 3838, 3860, 3936, 3964, 4047, 4064, 4282, 4298, 4428, 4524, 4591, 4694, 4710, 4724, 4782, 4803, 4837, 4967, 5124, 5164, 5194, 5376, 5734], 'crude': [111, 361, 1919, 3325, 4784], 'membrane': [112, 362, 2593, 2608, 3326, 3365, 3375, 3383, 3961, 4785, 4805, 4838, 4871], 'extract': [113, 363, 3366, 3384, 4806], 'napsin-transfected': [115, 365, 3386, 4788, 4808, 4841], 'resulted': [117, 213, 367, 463, 3769, 3864, 5033], 'enhanced': [119, 369, 520, 4800], 'levels': [120, 216, 370, 466, 1502, 1509, 4328, 4445, 4794, 5859, 5934, 5954, 6165], 'Purified': [125, 375, 2352, 2527], 'napsin': [126, 208, 376, 458, 1273, 1430, 1523, 1578, 1643, 1707, 1760, 1768, 1794, 1841, 1885, 1923, 1967, 2007, 2018, 2141, 2947, 2962, 2976, 3012, 3063, 3111, 3135, 3146, 3276, 3339, 3489, 3517, 3542, 3582, 3672, 3761, 3792, 3906, 3993, 4117, 4166, 4197, 4226, 4267, 4303, 4326, 4346, 4407, 4576, 4665, 4676, 4719, 4758, 4812, 4970, 4994, 5116, 5143, 5168, 5189, 5261, 5373, 5414, 5753, 5789, 5849, 5875, 5942, 6060, 6147, 6320], 'cleaved': [127, 162, 187, 377, 412, 437, 3580, 3599, 3644, 3659, 3676, 3793, 3878, 3903, 3970, 4088, 4164, 4173, 4182, 4995, 5114, 5190, 5262, 5415, 5776], 'recombinant': [129, 379, 1793, 1922, 2297, 2353, 2518, 2528, 2643, 2945, 2975, 3497, 3702, 3714, 4877, 4957, 4965, 5006, 5029, 5037, 5074, 5380, 5516, 5709], 'SP-B/EGFP': [130, 163, 380, 413, 2421, 2508, 2529, 4134, 4152, 4161], 'fusion': [131, 164, 381, 414, 2509, 3725, 3796, 3858, 3880, 4082, 4135, 4153, 5016, 5111, 5280, 5311, 5711], 'within': [133, 202, 383, 452, 613, 3677, 3867, 4126, 4997, 5416, 5424, 5725], 'between': [137, 190, 387, 440, 3731, 3798, 3882, 3904, 4029, 4090, 4175, 4183, 4191, 5079, 5117, 5191, 5263, 5527, 5729, 5807], 'Leu178': [138, 388, 3799, 5268], 'Pro179,': [140, 390, 3801], '22': [141, 391, 3802, 3826], 'amino': [142, 167, 392, 417, 3803, 3887, 4019, 5118, 5266], 'acids': [143, 168, 393, 418, 2458, 3804, 3888, 4020, 5088], 'upstream': [144, 169, 394, 419, 3681, 3805, 3889], 'NH2': [147, 172, 397, 422, 3684, 3808, 3892, 3911, 3921, 5763, 6390], 'terminus': [148, 173, 398, 423, 3685, 3809, 3893, 3912, 3922, 4001, 4105, 5764, 6231, 6366, 6391], 'SP-B.': [151, 176, 401, 426, 4517, 5767], 'Cathepsin': [152, 402, 2221, 2429, 2802, 3272, 3596, 4248, 5576, 6361], 'H,': [153, 233, 403, 483, 1593, 3938, 5537, 5577, 5681, 5756], 'cysteine': [155, 405, 5532], 'also': [157, 407, 786, 1028, 1450, 1595, 3216, 3863, 4008, 4376, 4426, 4708, 4833, 5302, 5775, 5931, 6372], 'implicated': [158, 408, 1596, 6339], 'pro-SP-B': [160, 410, 3498, 4145, 4221, 4996, 5008, 5913, 6324, 6337], 'processing,': [161, 411, 5692], '13': [166, 416, 3886], 'did': [178, 428, 3917, 4075, 5303, 5421], 'not': [179, 429, 2964, 3249, 3694, 3918, 4076, 4399, 4466, 5283, 5304, 5422, 5887, 5903, 6173, 6192, 6214], 'peptide,': [183, 433, 2653, 3656, 4129, 4991, 5399], 'whereas': [184, 434, 3033, 4205], 'cathepsin': [185, 232, 435, 482, 1592, 1645, 2382, 2554, 3565, 3619, 3633, 3674, 3861, 3876, 3901, 3931, 3937, 3995, 4086, 4096, 4119, 4171, 4206, 4228, 4433, 4442, 5536, 5702, 5739, 5755, 5773, 5791, 5816, 6189, 6211, 6224], 'H': [186, 436, 1646, 2383, 2555, 2803, 3566, 3597, 3620, 3634, 3675, 3862, 3877, 3902, 3996, 4087, 4097, 4120, 4172, 4207, 4229, 4249, 4443, 5703, 5774, 5792, 5817, 6190, 6212, 6225, 6362], 'boundary': [189, 439, 5806], 'at': [198, 235, 448, 485, 2170, 2178, 2182, 2199, 2299, 2402, 2412, 2448, 2478, 2571, 3034, 3941, 4123, 5199, 5745, 5782, 6068], 'several': [199, 449, 5783], 'other': [200, 238, 450, 488, 1288, 4124, 4394, 4594, 4866, 5274, 5835], 'sites': [201, 451, 4231, 5276, 5288, 5371, 5787, 5803, 5838], 'peptide.': [205, 249, 455, 499, 3689, 3813, 4422, 6315], 'Knockdown': [206, 456, 4244, 4423], 'small': [210, 460, 516], 'interfering': [211, 461, 517], 'RNA': [212, 462, 1692], 'decreased': [215, 465, 4441, 5933, 5953, 6164, 6181], 'SP-C': [222, 472, 2691, 4372, 5937, 5957, 6171], 'These': [227, 477, 4403, 4843, 5313], 'results': [228, 478, 602, 773, 939, 3210, 3840, 5126, 5248, 5314], 'suggest': [229, 479, 1576, 4405, 6162, 6318], 'that': [230, 480, 684, 772, 821, 1031, 1449, 1577, 3401, 3577, 3584, 3605, 3671, 3791, 3833, 3875, 4095, 4287, 4406, 4506, 4664, 4714, 4757, 4811, 4946, 4974, 4993, 5025, 5167, 5187, 5259, 5286, 5292, 5744, 5815, 6074, 6163, 6210, 6223, 6238, 6302, 6319], 'napsin,': [231, 481, 2032, 2645, 4066, 5579, 5772, 5869], 'least': [236, 486, 3035, 5746], 'one': [237, 487, 5747, 5799], 'enzyme': [239, 489, 5519, 6204], 'are': [240, 490, 5793, 6154, 6172, 6306], 'involved': [241, 491, 3278, 4209, 4512, 4667, 4814, 5542, 5758, 5819, 6215, 6307, 6332, 6374], 'maturation': [243, 493], 'biologically': [246, 496, 873, 4419, 4895, 6242, 6311, 6394], 'active': [247, 497, 874, 4420, 4896, 6312, 6395], '1The': [504], 'abbreviations': [505], 'used': [506, 4071, 5714, 6133], 'are:': [507], 'SP-B,': [508, 5075, 5517], 'surfactant': [509, 536, 605, 690], 'B;': [511], 'NTA,': [512], 'nitrilotriacetic': [513], 'acid;': [514], 'siRNA,': [515, 6136, 6148], 'RNA;': [518], 'EGFP,': [519], 'green': [521, 3979], 'fluorescent': [522, 3980, 4283, 5181], 'protein;': [523], 'HA,': [524], 'hemagglutinin;': [525], 'Tricine,': [526], 'N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]glycine.': [527], '79-amino': [530], 'acid,': [531], 'hydrophobic': [532, 5192, 5265], 'associated': [534, 1533], 'phospholipids': [537], 'airspaces': [541, 785], '(1Weaver': [545], 'T.E.': [546, 628, 653, 805, 894, 949, 970, 988, 1093, 1468, 1548, 1678, 1829, 1872, 1938, 1985, 2341, 2672, 2884, 3094, 3163, 3435, 3456, 3468, 4490, 4917, 5058, 5976, 6345], 'Conkright': [547, 1669, 2875], 'J.J.': [548, 1670, 2876, 5656], 'Annu.': [549], 'Rev.': [550], 'Physiol.': [551, 666, 808, 836, 975, 998, 1020, 1102, 1681, 1995, 2703, 2887, 3461, 3477, 4499, 6049, 6354], '2001;': [552, 1181, 1381, 4741, 5628], '63:': [553], '555-578Crossref': [554], 'PubMed': [555, 572, 641, 708, 733, 760, 812, 840, 906, 964, 1059, 1106, 1165, 1184, 1203, 1223, 1259, 1333, 1384, 1422, 1486, 1566, 1626, 1685, 1735, 1754, 1835, 1879, 1945, 2282, 2347, 2679, 2891, 3100, 3175, 3242, 3450, 3481, 4503, 4545, 4565, 4610, 4652, 4744, 4929, 5064, 5216, 5242, 5362, 5475, 5571, 5608, 5631, 5668, 5989, 6009, 6034, 6053, 6107, 6127, 6297, 6358], 'Scopus': [556, 573, 642, 709, 734, 761, 813, 841, 907, 965, 1060, 1166, 1185, 1204, 1224, 1260, 1334, 1385, 1423, 1487, 1567, 1627, 1686, 1736, 1755, 1836, 1880, 1946, 2283, 2348, 2680, 2892, 3101, 3176, 3243, 3451, 4546, 4566, 4611, 4653, 4745, 4930, 5065, 5217, 5243, 5363, 5476, 5572, 5609, 5632, 5669, 5990, 6010, 6035, 6108, 6128, 6298], '(309)': [557], 'Google': [558, 575, 644, 670, 711, 736, 763, 815, 843, 909, 967, 979, 1002, 1024, 1062, 1107, 1168, 1187, 1206, 1226, 1262, 1336, 1387, 1425, 1489, 1569, 1629, 1688, 1738, 1757, 1838, 1882, 1948, 1999, 2285, 2350, 2682, 2707, 2894, 3103, 3178, 3245, 3453, 3465, 3482, 4504, 4548, 4568, 4613, 4655, 4747, 4932, 5067, 5219, 5245, 5365, 5478, 5574, 5611, 5634, 5671, 5992, 6012, 6037, 6054, 6110, 6130, 6300, 6359], 'Scholar,': [559, 645, 712, 737, 968, 980, 1003, 1169, 1188, 1207, 1227, 1337, 1388, 1739, 3454, 3466, 4549, 4614, 5220, 5612, 5635, 5993, 6013, 6038, 6111], '2Hawgood': [560], 'S.': [561, 636, 884, 1005, 1095, 1151, 1153, 1235, 1253, 1309, 1327, 1365, 1379, 1398, 1606, 1721, 1723, 1866, 1932, 2666, 3470, 4492, 4622, 4638, 5332, 5348, 5445, 5461, 5551, 5984, 6115, 6267, 6283, 6347], 'Derrick': [562, 4625, 5335, 5448, 6270], 'M.': [563, 661, 745, 797, 1339, 1355, 1357, 1361, 1394, 1458, 1538, 1616, 1674, 1743, 2268, 2696, 2880, 3167, 4618, 4626, 4907, 5328, 5336, 5441, 5449, 5561, 5618, 5644, 6093, 6263, 6271], 'Poulain': [564], 'F.': [565, 1215, 1612, 1614, 4557, 4616, 4640, 5222, 5326, 5350, 5439, 5463, 5557, 5559, 5637, 5658, 6261, 6285], 'Biochim.': [566, 958, 1873, 1939, 2673, 3444, 5210], 'Biophys.': [567, 959, 1874, 1940, 2674, 3445, 5211], 'Acta.': [568, 960, 1875, 1941, 2675, 3446, 5212], '1998;': [569], '1408:': [570], '150-160Crossref': [571], '(193)': [574], 'Scholar).': [576, 671, 764, 816, 844, 910, 1025, 1063, 1108, 1263, 1426, 1490, 1570, 1630, 1839, 1883, 1949, 2000, 2286, 2351, 2708, 2895, 3246, 3483, 4569, 4656, 4748, 4933, 5068, 5246, 5575, 6055, 6131, 6360], 'facilitates': [578], 'formation': [580], 'maintenance': [582], 'phospholipid-rich': [585], 'film': [586], '(pulmonary': [587], 'surfactant)': [588], 'along': [589], 'epithelial': [592, 855, 3127, 3205, 3254, 3289, 4483, 4587], 'surface.': [593], 'Targeted': [594], 'disruption': [595], 'locus': [599], 'mice': [601, 1530, 1960, 2869, 4901], 'altered': [604, 4467], 'structure': [606], 'function,': [608], 'leading': [609, 5502, 6081], 'respiratory': [611, 682, 790], 'failure': [612, 683, 791], 'minutes': [614], 'birth': [616], '(3Clark': [617, 5965], 'J.C.': [618, 651, 801, 1472, 1552, 4911, 5966], 'Wert': [619, 1465, 1545, 5967], 'S.E.': [620, 1466, 1546, 5968], 'Bachurski': [621, 1469, 1549, 5969], 'C.J.': [622, 1470, 1550, 5970], 'Stahlman': [623, 3166, 5971], 'M.T.': [624, 3086, 5972], 'Stripp': [625, 5973], 'B.R.': [626, 5974, 6100], 'Weaver': [627, 652, 804, 893, 948, 987, 1467, 1547, 1677, 1828, 1871, 1937, 1984, 2340, 2671, 2883, 3093, 3434, 4916, 5057, 5975], 'Whitsett': [629, 648, 746, 802, 891, 956, 971, 989, 1473, 1553, 1986, 3091, 3442, 3457, 4912, 5977, 6045], 'J.A.': [630, 649, 747, 803, 892, 957, 972, 990, 1474, 1554, 1987, 3092, 3443, 3458, 4913, 5978, 6046], 'Proc.': [631, 1374, 5979], 'Natl.': [632, 1375, 5980], 'Acad.': [633, 1376, 5981], 'Sci.': [634, 1377, 5982], 'U.': [635, 1378, 5983], 'A.': [637, 739, 1043, 1175, 1194, 1231, 1305, 1349, 1380, 1825, 2337, 3233, 4536, 4601, 4735, 5054, 5640, 5985, 6117], '1995;': [638, 5986, 6050], '92:': [639, 5987], '7794-7798Crossref': [640, 5988], '(564)': [643, 5991], '4Tokieda': [646], 'K.': [647, 655, 1141, 1147, 1157, 1159, 1171, 1190, 1237, 1311, 1369, 1402, 1404, 1711, 1717, 1727, 1729, 3229, 4532, 4597, 4731], 'Clark': [650, 800, 1471, 1551, 4910], 'Ikeda': [654], 'McConnell': [656], 'K.B.': [657], 'Jobe': [658, 2699, 4914], 'A.H.': [659, 2700, 4915], 'Ikegami': [660, 796, 1673, 2695, 2879, 4906], 'Iwamoto': [662, 4908], 'H.S.': [663, 4909], 'Am.': [664, 806, 834, 973, 996, 1018, 1100, 1617, 1679, 1993, 2701, 2885, 3459, 3475, 4497, 5562, 5659, 6047, 6352], 'J.': [665, 703, 727, 752, 807, 835, 895, 974, 997, 1009, 1019, 1048, 1101, 1363, 1373, 1416, 1475, 1555, 1618, 1680, 1747, 1749, 1994, 2271, 2702, 2886, 3460, 3476, 4498, 4634, 4641, 4918, 5231, 5344, 5351, 5457, 5464, 5563, 5654, 5660, 6004, 6028, 6048, 6279, 6286, 6353], '1997;': [667, 1162, 1732, 4921], '273:': [668], 'L875-L882PubMed': [669], 'Similarly,': [672], 'hereditary': [673], 'deficiency': [675, 767, 5961], 'human': [677, 1906, 2031, 2229, 2470, 3703, 4233, 4969, 5007, 5188, 5260], 'infants': [678], 'leads': [679, 787], 'postnatal': [681, 827], 'invariably': [686], 'fatal': [687], 'even': [688], 'replacement': [691], 'therapy': [692], '(5Nogee': [693], 'L.M.': [694, 714, 751, 993, 1990, 5995, 6015, 6044], 'deMello': [695, 723, 742, 5996, 6024], 'D.E.': [696, 724, 743, 5997, 6025], 'Dehner': [697, 5998], 'L.P.': [698, 5999], 'Colten': [699, 725, 748, 6000, 6026], 'H.R.': [700, 726, 749, 6001, 6027], 'N.': [701, 1145, 1408, 1715, 4630, 5340, 5453, 5646, 6002, 6275], 'Engl.': [702, 6003], 'Med.': [704, 6005], '1993;': [705, 1021, 6006], '328:': [706, 6007], '406-410Crossref': [707, 6008], '(548)': [710, 6011], '6Nogee': [713, 6014], 'Garnier': [715, 6016], 'G.': [716, 1247, 1321, 1392, 4628, 5338, 5451, 5620, 5642, 6017, 6273], 'Dietz': [717, 6018], 'H.C.': [718, 6019], 'Singer': [719, 6020], 'L.': [720, 1608, 5553, 6021], 'Murphy': [721, 6022], 'A.M.': [722, 6023], 'Clin.': [728, 6029], 'Investig.': [729, 3096, 6030], '1994;': [730, 754, 6031], '93:': [731, 6032], '1860-1863Crossref': [732, 6033], '(477)': [735, 6036], '7Hamvas': [738], 'Cole': [740], 'F.S.': [741, 833], 'Moxley': [744], 'Nogee': [750, 6043], 'Pediatr.': [753], '125:': [755], '356-361Abstract': [756], 'Full': [757, 901, 903, 1054, 1056, 1481, 1483, 1561, 1563, 2277, 2279, 4647, 4649, 4924, 4926, 5237, 5239, 5357, 5359, 5470, 5472, 6292, 6294], 'Text': [758, 902, 904, 1055, 1057, 1482, 1484, 1562, 1564, 2278, 2280, 4648, 4650, 4925, 4927, 5238, 5240, 5358, 5360, 5471, 5473, 6293, 6295], 'PDF': [759, 905, 1058, 1485, 1565, 2281, 4651, 4928, 5241, 5361, 5474, 6296], '(114)': [762], 'Acute': [765], 'adult': [770, 1661, 1959, 2994, 3008], 'decrease': [776, 4344, 4352], 'concentration': [779, 4370, 4392, 4461], '75–80%': [781], 'lethal': [789], '(8Melton': [792], 'K.R.': [793], 'Nesslein': [794], 'L.L.': [795], 'Tichelaar': [798], 'J.W.': [799], '2003;': [809, 837, 1478, 1558, 1623, 4644, 5354, 5467, 5568, 6104, 6124, 6289], '285:': [810, 838], 'L543-L549Crossref': [811], '(142)': [814, 1687, 2893], 'Collectively,': [817], 'these': [818, 1573, 4299, 4439, 5287, 5528, 5897], 'data': [819, 1574, 4404, 6317], 'indicate': [820], 'absolutely': [824], 'required': [825, 3049, 5851, 5948], 'for': [826, 1493, 1790, 1963, 2137, 2173, 2185, 2311, 2405, 2574, 3295, 3543, 3567, 3696, 3762, 3944, 4432, 5197, 5299, 5717, 5852, 5874, 5949, 6188, 6323, 6386, 6405, 6415], 'function': [829], 'survival': [831], '(9Cole': [832], 'L540-L542Crossref': [839], '(16)': [842], 'non-ciliated': [858], 'bronchiolar': [859, 3257], '(Clara)': [860], 'lung;': [864], 'however': [865, 4453], 'complete': [866, 3588, 6201], 'precursor': [870], 'occurs': [877, 4473], 'only': [878, 3381], '(10Lin': [883], 'Na': [885, 1671, 2877, 3164], 'C.L.': [886, 1672, 2878, 3165], 'Akinbi': [887], 'H.T.': [888, 4903], 'Apsley': [889], 'K.S.': [890, 1827, 1868, 1934, 2339, 2668, 5056], 'Biol.': [896, 1049, 1476, 1556, 1622, 2272, 3171, 4642, 4919, 5232, 5352, 5465, 5567, 5664, 6103, 6287], 'Chem.': [897, 1050, 1477, 1557, 2273, 4643, 4920, 5233, 5353, 5466, 6288], '1999;': [898, 1220, 1256, 1330, 2274, 2704, 4562], '274:': [899, 2275], '19168-19174Abstract': [900], '(53)': [908], 'The': [911, 1264, 1631, 1767, 1884, 1908, 2108, 2188, 2484, 2577, 2592, 2709, 2730, 2744, 2773, 2810, 2908, 3107, 3298, 3414, 3613, 3643, 3723, 3814, 3854, 3947, 3960, 3990, 4342, 4369, 4435, 4793, 5247, 5785, 5830, 6380], 'traffics': [913], 'through': [914, 4476], 'secretory': [916, 4478, 4953], 'pathway': [917, 4479, 4954, 6080], 'cell': [922, 1291, 1765, 3850, 4778], 'body/late': [926], 'endosome': [927], 'compartment': [928], 'where': [929], 'sequential': [930], 'domains': [938, 4219], 'generation': [941, 3772, 4817, 5760, 6387], "(11O'Reilly": [946, 3432], 'M.A.': [947, 3433], 'Pilot-Matias': [950, 3436], 'T.J.': [951, 3437], 'Sarin': [952, 3438], 'V.K.': [953, 3439], 'Gazdar': [954, 3440], 'A.F.': [955, 3441], '1989;': [961, 976, 3447, 3462], '1011:': [962, 3448], '140-148Crossref': [963, 3449], '(59)': [966, 3452], '12Weaver': [969, 3455], '257:': [977, 3463], 'L100-L108PubMed': [978, 3464], '13Voorhout': [981], 'W.F.': [982, 1979], 'Veenendaal': [983, 1980], 'T.': [984, 1013, 1149, 1177, 1196, 1217, 1233, 1243, 1307, 1317, 1341, 1345, 1390, 1400, 1410, 1719, 1981, 3235, 4538, 4559, 4603, 4620, 4636, 4737, 5209, 5330, 5346, 5443, 5459, 6265, 6281], 'Haagsman': [985, 1982], 'H.P.': [986, 1983], 'van': [991, 1988], 'Golde': [992, 1989], 'Geuze': [994, 1991], 'H.J.': [995, 1992], '1992;': [999, 1103, 1996, 3478, 4500, 6355], '263:': [1000, 1104, 1997, 3479, 4501, 6356], 'L479-L486PubMed': [1001, 1998], '14Hawgood': [1004], 'Latham': [1006], 'D.': [1007, 1011, 1211, 1213, 1245, 1319, 1367, 1460, 1540, 4553, 4555, 5224], 'Borchelt': [1008], 'Damm': [1010], 'White': [1012], 'Benson': [1014], 'B.': [1015, 1097, 1241, 1315, 1353, 1406, 3472, 4494, 6349], 'Wright': [1016, 5204], 'J.R.': [1017], '264:': [1022], 'L290-L299PubMed': [1023], 'There': [1026, 4378], 'some': [1029], 'evidence': [1030, 4381], 'may': [1036, 1069, 4845, 4861, 5489, 5521, 5958, 6327, 6371], 'be': [1037, 1086, 1123, 1434, 4890, 5541, 5583, 6066, 6328, 6373], 'initiated': [1038], 'Golgi': [1041], '(15Korimilli': [1042], 'Gonzales': [1044], 'L.W.': [1045], 'Guttentag': [1046, 4621, 5331, 5444, 6266], 'S.H.': [1047], '2000;': [1051, 1419, 1751, 3097, 5213], '275:': [1052], '8672-8679Abstract': [1053], '(57)': [1061], 'Pro-SP-B': [1064], 'complex': [1067, 5043], 'involve': [1070], 'multiple': [1071, 5369, 6303], 'enzymes': [1072, 2085, 6305], 'sites.': [1075, 2453, 2483, 5508, 5784], 'Proteolytic': [1076], 'reported': [1083, 1120, 3226, 4487], 'previously': [1084, 1666, 1823, 1864, 1930, 1975, 2335, 2872, 3227, 3423, 4488, 4888, 5024], 'mediated': [1087], '(16Weaver': [1092, 4489, 6344], 'Lin': [1094, 3469, 4491, 6346], 'Bogucki': [1096, 3471, 4493, 6348], 'Dey': [1098, 3473, 4495, 6350], 'C.': [1099, 1745, 3474, 4496, 6351], 'L95-L103Crossref': [1105, 3480, 4502, 6357], 'A': [1109, 1971, 2409, 3593, 5531, 5720, 5841, 6056], 'novel': [1110], 'very': [1115, 4526], 'restricted': [1116, 4200, 4527], 'pattern': [1118, 4455, 4528, 5256], 'recently': [1121], 'predominantly': [1125], 'proximal': [1134], 'tubule': [1135], 'kidney': [1139, 1956, 2998, 3018, 3031, 3126, 3204], '(17Mori': [1140, 1710], 'Ogawa': [1142, 1712], 'Y.': [1143, 1173, 1229, 1303, 1343, 1347, 1396, 1412, 1464, 1544, 1713, 4733, 5596, 5598, 5602, 5614, 5616, 5624], 'Tamura': [1144, 1714], 'Ebihara': [1146, 1411, 1716], 'Aoki': [1148, 1718], 'Muro': [1150, 1720], 'Ozaki': [1152, 1722], 'Tanaka': [1154, 1724], 'I.': [1155, 1725], 'Tashiro': [1156, 1726], 'Nakao': [1158, 1728], 'FEBS': [1160, 1218, 1254, 1328, 1730, 4560], 'Lett.': [1161, 1219, 1255, 1329, 1731, 4561], '401:': [1163, 1733], '218-222Crossref': [1164, 1734], '(33)': [1167, 1737], '18Mori': [1170], 'Kon': [1172, 4732], 'Konno': [1174, 1193, 3232, 4535, 4600, 4734], 'Iwanaga': [1176, 1195, 3234, 4537, 4602, 4736], 'Arch.': [1178, 1197, 3236, 4539, 4604, 4738, 5625], 'Histol.': [1179, 1198, 3237, 4540, 4605, 4739, 5626], 'Cytol.': [1180, 1199, 3238, 4541, 4606, 4740, 5627], '64:': [1182, 4742, 5629], '319-327Crossref': [1183, 4743], '(21)': [1186, 4746], '19Mori': [1189], 'Shimizu': [1191, 3230, 4533, 4598], 'H.': [1192, 1251, 1325, 1414, 3231, 3932, 4434, 4534, 4599, 5230, 5652, 5740], '2002;': [1200, 1682, 2888, 3172, 3239, 4542, 4607, 5234, 5665], '65:': [1201, 3240, 4543, 4608], '359-368Crossref': [1202, 3241, 4544, 4609], '(28)': [1205, 3244, 4547, 4612], '20Schauer-Vukasinovic': [1208, 4550], 'V.': [1209, 1351, 4551, 4624, 5203, 5207, 5334, 5447, 6269], 'Bur': [1210, 4552], 'Kling': [1212, 4554], 'Gruninger': [1214, 4556], 'Giller': [1216, 4558, 4635, 5208, 5345, 5458, 6280], '462:': [1221, 1257, 1331, 4563], '135-139Crossref': [1222, 4564], '(51)': [1225, 4567], '21Chuman': [1228], 'Bergman': [1230, 1242, 1304, 1316], 'Ueno': [1232, 1306], 'Saito': [1234, 1308], 'Sakaguchi': [1236, 1310], 'Alaiya': [1238, 1312], 'A.A.': [1239, 1313], 'Franzen': [1240, 1314, 1405], 'Arnott': [1244, 1318], 'Auer': [1246, 1320, 1391], 'Appella': [1248, 1322], 'E.': [1249, 1323, 5019, 5226, 5600, 5622], 'Jornvall': [1250, 1324], 'Linder': [1252, 1326], '129-134Crossref': [1258, 1332], '(99)': [1261, 1335], 'gene': [1265, 1521], 'encoding': [1266, 1522, 1903, 2224, 2960], 'this': [1267, 3585, 4819, 5160, 5255, 6159, 6239, 6252, 6424], 'protease,': [1268, 5533], 'variously': [1269], 'referred': [1270, 1282], 'A,': [1274, 3557], 'kidney-derived': [1275], 'aspartic': [1276, 3561, 4509], 'protease-like': [1277], 'protein,': [1278], 'or': [1279, 1895, 1905, 2111, 2365, 2380, 2540, 2552, 2625, 3000, 3256, 3333, 3553, 3563, 3629, 4118, 4336, 4789, 5428, 5518, 5891, 5928], 'TAO2': [1280], '(herein': [1281], 'napsin),': [1285], 'clusters': [1286], 'genes': [1292], 'which': [1294, 3154, 4691], 'significantly': [1297, 5316], 'up-regulated': [1298], 'adenocarcinomas': [1301], '(21Chuman': [1302], '22Nacht': [1338], 'Dracheva': [1340], 'Gao': [1342], 'Fujii': [1344], 'Chen': [1346], 'Player': [1348], 'Akmaev': [1350], 'Cook': [1352, 1742], 'Dufault': [1354], 'Zhang': [1356, 1358, 1609, 5554, 5619], 'W.': [1359, 2698], 'Guo': [1360], 'Curran': [1362], 'Han': [1364], 'Sidransky': [1366], 'Buetow': [1368], 'Madden': [1370], 'S.L.': [1371], 'Jen': [1372], '98:': [1382], '15203-15208Crossref': [1383], '(124)': [1386], '23Hirano': [1389], 'Maeda': [1393], 'Hagiwara': [1395], 'Okada': [1397], 'Ohira': [1399], 'Okuzawa': [1401], 'Fujioka': [1403], 'Hibi': [1407], 'Seito': [1409], 'Kato': [1413], 'Jpn.': [1415], 'Cancer': [1417], 'Res.': [1418], '91:': [1420], '1015-1021Crossref': [1421], '(64)': [1424, 4931], 'Importantly,': [1427, 5798], 'shown': [1432, 3422, 4887, 5023, 5581, 6073], 'regulated': [1435], 'TTF-1,': [1437], 'phosphorylated': [1439], 'member': [1440], 'Nkx2': [1443], 'family': [1444, 3158], 'homeodomain-containing': [1446], 'transcription': [1447], 'factors': [1448], 'regulates': [1451], 'lung-specific': [1453], '(24DeFelice': [1457, 1537], 'Silberschmidt': [1459, 1539], 'DiLauro': [1461, 1541], 'R.': [1462, 1542, 6121], 'Xu': [1463, 1543], '278:': [1479, 1559, 4645, 5355, 5468, 6290], '35574-35583Abstract': [1480, 1560], '(136)': [1488, 1568], 'Mice': [1491], 'homozygous': [1492], 'mutant': [1495], 'hypophosphorylation': [1496], 'TTF-1': [1497], 'allele': [1498], '(Titf1PM/PM)': [1499], 'lower': [1501, 4824], 'increased': [1508, 4386, 4725], 'proprotein.': [1511, 1588, 1651, 4673, 4765, 5409], 'Consistent': [1512], 'defect,': [1517], 'down-regulated': [1525], '∼21-fold': [1527], 'Titf1PM/PM': [1529], 'neonatal': [1535], 'lethality': [1536], 'Taken': [1571], 'together,': [1572], 'strongly': [1575, 6237], 'plays': [1579, 4408], 'important': [1581, 5872], 'role': [1582, 3487, 4411, 5873], 'Recently': [1589], 'another': [1590], 'enzyme,': [1591, 5749], '(25Guttentag': [1605, 5550], 'Robinson': [1607, 5552], 'P.': [1610, 5228, 5555], 'Brasch': [1611, 5322, 5435, 5556, 6257], 'Buhling': [1613, 4639, 5349, 5462, 5558, 5657, 6284], 'Beers': [1615, 5560, 5649], 'Respir.': [1619, 5564, 5661], 'Cell': [1620, 3169, 5565, 5662, 6102], 'Mol.': [1621, 5566, 5663], '28:': [1624, 5569], '69-79Crossref': [1625, 5570], '(65)': [1628, 5573], 'current': [1632, 5251], 'study': [1633, 4713, 5252, 5320, 5488, 6253, 6343], 'therefore': [1635], 'undertaken': [1636], 'directly': [1638], 'assess': [1639, 3485], 'ability': [1641, 3991, 4100, 4323], 'process': [1648, 4073], 'Generation': [1652, 2001, 2213, 2417], 'Antibody—Type': [1655], 'were': [1658, 1700, 1961, 2092, 2103, 2127, 2135, 2153, 2293, 2464, 2489, 2520, 2580, 2603, 2621, 2711, 2732, 2759, 2782, 2819, 2863, 3130, 3291, 3320, 3354, 3402, 3646, 3661, 3709, 3716, 3949, 4155, 4295, 4305, 4317, 4425, 4465, 4799, 4832, 5282, 5289, 5863, 6191, 6197], 'isolated': [1659, 1694, 2864, 3006, 3328, 3508, 4310], 'mouse': [1662, 1706, 1904, 2644, 2946, 2961, 2995, 3009, 3125, 3286, 4274], 'lungs': [1663], 'described': [1665, 1822, 1863, 1929, 1974, 2260, 2334, 2871], '(26Rice': [1667, 2873], 'W.R.': [1668, 2874], 'Shannon': [1675, 2881], 'J.M.': [1676, 2882], '283:': [1683, 2889], 'L256-L264Crossref': [1684, 2890], 'Scholar),': [1689, 2683, 5479], 'total': [1691], 'reverse': [1696], 'transcribed.': [1697], 'PCR': [1698, 2024, 2435, 2467], 'primers': [1699, 2029], 'designed': [1701], 'based': [1702, 4320], 'on': [1703, 2623, 4321, 4721, 4727], 'published': [1705], 'DNA': [1708], 'sequence': [1709, 2078, 2223, 3783, 3872], '27Tatnell': [1740], 'P.J.': [1741], 'Peters': [1744], 'Kay': [1746], 'Eur.': [1748], 'Biochem.': [1750], '267:': [1752], '6921-6930Crossref': [1753], '(11)': [1756, 5218], 'Scholar)': [1758, 3104, 3179, 4505, 5366, 5672, 6301], 'amplified': [1761, 2433, 2465], 'cDNA.': [1766, 3340], 'cDNA': [1769, 1902, 2008, 2019, 2431, 2472, 2959], 'subsequently': [1771, 3321, 4318], 'cloned': [1772, 2010, 2234, 2474], 'into': [1773, 1779, 1856, 2116, 2244, 2445, 4309, 4942], 'pET21': [1774], '(Novagen)': [1775, 2447], 'then': [1777], 'transformed': [1778, 2494], 'Escherichia': [1780], 'coli': [1781], 'BL21(DE3)': [1782, 2492], 'Following': [1784], 'induction': [1785], '0.1': [1787], 'mm': [1788, 1809, 1814, 1847, 1852, 2161, 2164, 2376, 2395, 2398, 2505, 2564, 2567], 'isopropyl-β-d-thiogalactoside': [1789], '4': [1791, 2171, 2183, 2200, 3639], 'h,': [1792], 'recovered': [1796, 3305, 3787], 'extraction': [1798], 'bacterial': [1801, 5105], 'pellet': [1802], '6': [1804], 'm': [1805, 2372, 2391, 2547, 2560], 'guanidine': [1806], '20': [1808, 1832, 2160, 2186, 2344, 2375, 2719, 5061], 'Tris,': [1810, 1848], 'pH': [1811, 1849, 2378, 2400, 2550, 2569, 3939], '7.9,': [1812], '500': [1813], 'NaCl': [1815], 'followed': [1816, 2098, 2442, 2584, 3953], 'NTA': [1818, 2327, 2514], 'affinity': [1819, 2194, 2328, 2515, 3534], 'chromatography,': [1820, 2329], '(28Holzinger': [1824, 2336, 5053], 'Phillips': [1826, 1867, 1933, 2338, 2667, 5055], 'BioTechniques.': [1830, 2342, 5059], '1996;': [1831, 1876, 1942, 2343, 2676, 5060], '(808):': [1833, 2345, 5062], '804-806Crossref': [1834, 2346, 5063], '(75)': [1837, 2349, 5066], 'Recombinant': [1840, 2215, 2248, 2314, 2419, 2507, 3536], 'dialyzed': [1843], 'against': [1844, 2642, 2649, 2657, 2688, 2942, 3312, 3652, 4988], 'TBS': [1845], '(20': [1846], '7.4,': [1850], '150': [1851], 'NaCl)': [1853], 'injected': [1855], 'rabbits': [1857], 'generate': [1859, 2015, 3602, 3919, 3998, 4102], 'polyclonal': [1860], 'antisera': [1861], '(29Lin': [1865, 1931, 2665], 'Wilder': [1869, 1935, 2669], 'M.R.': [1870, 1936, 2670], '1312:': [1877, 1943, 2677], '177-185Crossref': [1878, 1944, 2678], '(70)': [1881, 1947, 2681, 5670], 'antibody': [1886, 1968, 2146, 2940, 3136, 3310, 3409, 3631, 3650, 4986], 'characterized': [1888, 3113], 'Western': [1890, 1926, 2619, 2635, 2936, 2979, 2990, 3056, 3212, 3574, 5915], 'blotting': [1891, 1927, 2636, 2937, 2980, 2991, 3057, 3575, 5916], 'untransfected': [1892, 2966, 3330, 3370, 4790], 'HEK293': [1893, 1896, 2117, 2954, 3120, 3331, 3525, 4791], 'transiently': [1898], 'transfected': [1899, 2115, 2125, 2956, 3119, 3336, 3368, 4297, 4308], 'napsin.': [1907, 4854, 6184], 'specificity': [1909], 'immunoreaction': [1912], 'confirmed': [1914, 2490], 'absorption': [1916], 'antiserum': [1920, 2640, 2646, 2654, 2685, 2973], 'prior': [1924, 2977, 3073], 'Electron': [1950], 'Microscopy—Fixed': [1951], 'cryoprotected': [1952], 'frozen': [1953], 'tissues': [1957], 'immunogold': [1964], 'labeling': [1965, 3200], 'gold': [1972], 'detail': [1977], '(13Voorhout': [1978], 'Purification': [2003], 'Human': [2005, 2420, 2454, 3516], 'Napsin—Human': [2006], 'pEGFP-N3': [2012, 2082, 2437], '(Clontech).': [2013], 'To': [2014, 3484, 4113, 5069, 5699], 'HA-tagged': [2017], '(not': [2020, 3054, 3122, 3223, 4401, 4468, 5899], 'fused': [2021, 3706, 5091], 'EGFP),': [2023], 'performed': [2026, 2638, 2901, 5845], 'using': [2027, 2083, 2119, 2436, 3531, 5179], 'specific': [2028, 4658], '5′': [2033], 'primer': [2034, 2047], 'agc': [2035, 2037, 2056, 2827], 'gct': [2036], 'atg': [2038], 'tct': [2039], 'cca': [2040, 2041, 2828, 2833], 'ccg': [2042], 'ctg': [2043, 2068, 2070], 'ct': [2044], '3′': [2046], '(with': [2048], 'stop': [2050], 'codon)': [2051], 'cgc': [2052, 2069], 'gaa': [2053, 2067, 2791, 2824, 2832, 2840, 2841], 'ttc': [2054], 'tca': [2055, 2826], 'gta': [2057, 2062, 2064], 'gtc': [2058, 2061], 'tgg': [2059, 2063, 2797], 'gac': [2060], 'ccc': [2065, 2789], 'ggg': [2066, 2799], 'cg.': [2071], 'As': [2072, 2846, 5432], 'control': [2074, 2109, 4332, 4451, 4949, 6160], 'vector,': [2075], 'EGFP': [2077, 2477, 3708, 4048, 5015], 'removed': [2080], 'restriction': [2084], 'SalI': [2086], 'NotI': [2088], 'both': [2090, 3658, 4214], 'ends': [2091], 'filled': [2093], 'Klenow': [2096], 'fragment': [2097, 3789, 3972, 4012], 'self-ligation.': [2100], 'All': [2101, 2517, 3713], 'constructs': [2102, 2488, 2497, 6407], 'subjected': [2104, 2581, 2610], 'bidirectional': [2106], 'sequencing.': [2107], 'vector': [2110, 2367, 2542], 'napsin-HA': [2112, 2364, 2539], 'stably': [2114, 3118, 3335], 'LipofectAMINE': [2120], '(Invitrogen).': [2121], 'For': [2122], 'stable': [2123, 2361, 2536], 'expression,': [2124], 'selected': [2128, 4319], 'G418': [2130], '(Invitrogen)': [2131], 'G418-resistant': [2133], 'colonies': [2134], 'analyzed': [2136, 2750, 3974], 'immunoblotting': [2143], 'anti-HA': [2145, 2193, 3533], '(clone': [2147], '3F10;': [2148], 'Roche': [2149], 'Applied': [2150, 2197], 'Science).': [2151], 'Cells': [2152], 'lysed': [2154], 'lysis': [2156, 2209], 'buffer': [2157, 2210, 2370, 2389, 2545, 2558], '(phosphate-buffered': [2158], 'saline,': [2159], 'EDTA,': [2162, 2377, 2396, 2565], 'phenylmethylsulfonyl': [2165], 'fluoride,': [2166], '1%': [2167], 'Elugent': [2168], '(Calbiochem))': [2169], '°C': [2172, 2184, 2201, 2404, 2573, 3943], '30': [2174, 3036], 'min': [2175], 'centrifuged': [2177], '12,000': [2179], '×': [2180], 'g': [2181], 'min.': [2187], 'supernatant': [2189], 'incubated': [2191, 2356, 2531, 2722, 3322, 3539, 3935, 4781, 5375], 'matrix': [2195, 2205], '(Roche': [2196], 'Science)': [2198], 'overnight,': [2202], 'washed': [2207, 2712], 'six': [2211], 'times.': [2212], 'SP-BΔcand': [2216], 'Cleavage': [2217, 2425, 3260], 'H—The': [2222], 'residues': [2225, 3730, 3749, 3827, 4028, 5193, 5294], '1–279': [2226], '(SP-BΔc)': [2232], 'in-frame': [2235, 2475, 4046], 'six-residue': [2238], 'histidine': [2240], 'tag': [2241, 3521], 'ligated': [2243], 'pVL1393': [2245], '(BD': [2246], 'Biosciences).': [2247, 2729, 2755], 'baculovirus': [2249], 'produced': [2251, 3388, 3710, 3717, 4880, 5011, 5295, 5499], 'homologous': [2253], 'recombination': [2254], 'Spodoptera': [2256], 'frugiperda': [2257], 'McCormack': [2262], 'et': [2263, 5323, 5436, 6258], 'al.': [2264, 5324, 5437, 6259], '(30McCormack': [2265], 'F.X.': [2266], 'Damodarasamy': [2267], 'Elhalwagi': [2269], 'B.M.': [2270], '3173-3181Abstract': [2276], '(41)': [2284], 'Fresh': [2287], 'monolayers': [2288], 'Trichoplusia': [2290], 'ni': [2291], 'infected': [2294, 2323], 'plaque-purified': [2296], 'virus': [2298], 'multiplicity': [2301], 'infection': [2303], '2': [2305, 2406, 2575, 3544, 3568, 3763, 3945, 4365], 'cultured': [2307], 'serum-free': [2309], 'media': [2310], '72': [2312], 'h.': [2313, 2407, 2576, 3297, 3946], 'SP-BΔC': [2315, 2354, 3537, 3578, 3600], 'purified': [2317, 2512, 3042, 3528, 3757, 3847, 4062, 4968, 5103], 'culture': [2320], 'medium': [2321, 3299, 3362, 3511, 3851, 4774], 'insect': [2324, 3514, 3849, 4883, 4937], 'under': [2330, 4067], 'nondenaturing': [2331], 'conditions,': [2332, 5513], 'immunoprecipitates': [2358, 2533], 'transfectants': [2362, 2537], 'empty': [2366, 2541], 'incubation': [2369, 2388, 2544, 2557, 3855, 4802, 4836, 5512], '(0.1': [2371, 2390, 2546, 2559], 'sodium': [2373, 2392, 2548, 2561], 'acetate,': [2374], '4.7)': [2379], '(Biomol': [2384], 'Research': [2385], 'Laboratories)': [2386], 'phosphate,': [2393, 2549, 2562], '10': [2397, 2566], 'cysteine,': [2399, 2568], '6.8)': [2401, 2570], '37': [2403, 2572, 3548, 3572, 3767, 3942], 'Pepstatin': [2408], 'added': [2411], '50': [2413], 'ng/μl': [2414], 'indicated.': [2416], 'Bacteria': [2423], 'H—EGFP': [2430], '(Clontech)': [2438], 'template': [2441], 'cloning': [2444], 'pET28a': [2446], 'EcoRI': [2450, 2482], 'HindIII': [2452], 'fragments': [2456], '(amino': [2457, 5087], '146–207,': [2459], '272–298,': [2460], '294–320,': [2461], '318–381)': [2463], 'NheI': [2480], 'sequences': [2485, 2775, 2812, 4316, 4431], 'bidirectionally.': [2491], 'synthesis': [2500], 'induced': [2502], 'isopropyl-β-d-thiogalactoside.': [2506], 'chromatography.': [2516, 5109], 'proteins': [2519, 2524, 3715, 3720, 3948, 4136, 4154, 4395], 'soluble': [2523, 3719, 4056, 4158, 5014, 5099], 'bacteria.': [2526, 3712, 3722, 4059], '6.5)': [2551], 'reaction': [2578, 3621], 'products': [2579], 'SDS-PAGE': [2583, 3952], 'gel': [2586], 'transfer': [2587, 3955], 'polyvinylidene': [2589, 3957], 'difluoride': [2590, 3958], 'membrane.': [2591, 3959], 'stained': [2595, 3963], 'Coomassie': [2597, 3965], 'Brilliant': [2598, 3966], 'Blue,': [2599, 3967], 'individual': [2601], 'bands': [2602], 'cut': [2604], 'out': [2605, 2912], 'Edman': [2612, 3976], 'degradation': [2613], '(Protein': [2614], 'Analysis': [2615], 'Center,': [2616], 'Karolinska': [2617], 'Institute).': [2618], 'Blotting—Samples': [2620], 'resolved': [2622], '16.5': [2624], '10–20%': [2626], 'Tris/Tricine': [2627], 'SDS-polyacrylamide': [2628], 'gels': [2629], 'transferred': [2631], 'nitrocellulose': [2633], 'membranes.': [2634], 'directed': [2641, 2648, 2656, 2687, 2941, 3311, 3651, 4987], '28031': [2647], '55522': [2655], 'propeptides': [2662], '76694': [2686], '(31Ross': [2693], 'G.F.': [2694], 'Steinhilber': [2697], '277:': [2705, 5235], 'L1104-L1108PubMed': [2706], 'membranes': [2710, 2731], 'phosphate-buffered': [2714], 'saline': [2715], 'containing': [2716, 3300], '0.1%': [2717], 'Tween': [2718], '(Sigma)': [2720], 'horseradish': [2724], 'peroxidase-conjugated': [2725], 'anti-rabbit': [2726], 'Ig': [2727], '(Amersham': [2728, 2754], 'washed,': [2733], 'peroxidase': [2735], 'activity': [2736, 5737, 6177], 'developed': [2738], 'SuperSignal': [2740], 'West': [2741], 'Pico': [2742], '(Pierce).': [2743], 'intensity': [2745, 4726], 'signal': [2748], 'IMAGEQUANT': [2752], '5.0': [2753], 'siRNA—Mouse': [2756], 'napsin-specific': [2757], 'siRNAs': [2758, 2781, 2818, 2899, 4304, 4440], 'silencer': [2763], 'siRNA': [2764, 2804, 2851, 2916, 4284, 4315, 4335, 4430, 5842, 6075, 6186], 'construction': [2765], 'kit': [2766], '(Ambion)': [2767], 'according': [2768, 2854], "manufacturer's": [2771, 2857], 'protocol.': [2772, 2858], 'target': [2774, 2811], 'two': [2778, 4132, 5264, 5529], 'most': [2779, 2816, 4436, 5534, 5687], 'effective': [2780, 2817, 4437], 'follows:': [2784, 2821], 'siRNA2,': [2785], 'aat': [2786], 'ctt': [2787], 'aaa': [2788, 2843], 'act': [2790], 'tgg,': [2792], 'siRNA3,': [2794], 'aac': [2795, 2800], 'tat': [2796], 'ttt': [2798], 'gcc.': [2801], 'Cenix': [2808], 'Bioscience.': [2809], 'three': [2815, 4751], 'cath182,': [2822], 'aag': [2823, 2831, 2839], 'gat': [2825], 'caa;': [2829], 'cath206,': [2830], 'cac': [2834], 'att': [2835], 'taa': [2836], 'aat;': [2837], 'cath362,': [2838], 'agg': [2842], 'tgt': [2844], 'tgt.': [2845], 'control,': [2848], 'glyceraldehyde-3-phosphate': [2849, 4333, 6134], 'dehydrogenase': [2850, 4334, 4388, 6135], 'Mouse': [2859, 2931], '6-week-old': [2866], 'female': [2867], 'C57/6': [2868], 'Transfection': [2896], 'GeneSilencer': [2903], 'Reagent': [2904, 2923], '(Gene': [2905], 'Therapy': [2906], 'Systems).': [2907], 'transfection': [2909, 4337], 'carried': [2911], '100': [2914], 'nm': [2915], '5': [2918], 'μl': [2919], 'Gene': [2921], 'Silencer': [2922], '12-well': [2926], 'plate.': [2927], 'Expression': [2929], 'Lung': [2932], 'Kidney': [2934], 'Tissues—': [2935], 'bacterially': [2943, 5498], 'derived': [2944], 'single': [2950], 'immunoreactive': [2951, 3021], 'but': [2963, 3193, 3916, 5420, 6178], '(Fig.': [2968, 3105, 3137, 3152, 3183, 3317, 3372, 3410, 3594, 3611, 3635, 3753, 3779, 3852, 3898, 4049, 4111, 4146, 4167, 4222, 4278, 4340], '1A).': [2969], 'Absorption': [2970], 'completely': [2981, 4891], 'blocked': [2982], 'immunoreaction.': [2984], 'readily': [2987], 'lysates': [3001, 5106], 'lung.': [3010], 'However': [3011], 'considerably': [3014, 3195], 'more': [3015, 3188, 4133, 4288, 5748], 'abundant': [3016], 'tissue': [3019], 'because': [3020, 5905, 5922, 6174, 6179, 6195], 'less': [3026, 3196], 'than': [3027, 3198, 3663, 4289, 4978], 'μg': [3029, 3037], 'homogenate,': [3032], 'lysate': [3039], 'population': [3043], 'detect': [3051, 5912], 'shown).': [3055, 4402, 4469, 5900], '(32Stahlman': [3085], 'Gray': [3087], 'M.P.': [3088], 'Falconieri': [3089], 'M.W.': [3090], 'Lab.': [3095], '80:': [3098], '395-403Crossref': [3099], '(89)': [3102], '1B).': [3106], 'subcellular': [3108, 4659], 'localization': [3109, 4660], 'immunoelectron': [3115], 'microscopy.': [3116], 'In': [3117, 3139, 4084, 4169, 4195, 4570, 4674, 4766, 4873, 5001, 5271, 5410, 6246], 'shown)': [3123, 3224], 'lysosomes': [3129, 3202, 3219], 'heavily': [3131], 'labeled': [3132, 3292], '2A).': [3138], 'lung,': [3145, 4690], 'lamellar': [3150, 4579, 5586], 'bodies': [3151, 3182, 3192, 4580, 4583, 5590], '2B),': [3153], 'belong': [3155], 'lysozyme-related': [3160], 'organelles': [3161], '(33Weaver': [3162], 'Semin.': [3168], 'Dev.': [3170], '13:': [3173], '263-270Crossref': [3174], '(176)': [3177], '2C).': [3184], 'Labeling': [3185], 'somewhat': [3187], 'prominent': [3189], 'intense': [3197], 'consistent': [3207, 4693, 4709, 5123, 5163, 5733], 'blotting.': [3213], 'macrophages': [3222], '(19Mori': [3228, 4531, 4596], 'I': [3253], 'Clara': [3258], 'Propeptide': [3266], 'H—To': [3273], 'determine': [3274, 4115, 5700, 5847], 'whether': [3275, 4116, 5701, 5848], 'proteolytic': [3280, 6304], 'proprotein,': [3285, 3342, 4043], '35[S]methionine/cysteine': [3294], '3': [3296], 'secreted': [3301, 4941], 'immunoprecipitated': [3307, 3403], '3).': [3318, 3373], 'Immunoprecipitates': [3319], 'preparation': [3327, 5514, 5520], 'Mr': [3343, 3393, 3415, 3608, 3777], '=': [3344, 3352, 3416, 3609, 3668], '42,000,': [3345], 'major': [3348], 'intermediate': [3350, 3396, 3420, 4798, 4860, 5172, 6338], '(Mr': [3351, 3667], '∼25,000)': [3353], 'untreated': [3357, 5892], 'medium,': [3358, 4944], 'well': [3360, 3744], 'treated': [3363, 5890], 'Both': [3374, 4151], 'extracts': [3376, 4839], 'proprotein;': [3379], 'however,': [3380, 6065], 'increase': [3390], '∼25,000': [3394], 'smaller': [3399], 'peptides': [3400, 3645, 3660, 3705], '3,': [3411], 'lane': [3412, 3638, 3641], 'T).': [3413], '25,000': [3417], 'arise': [3425, 4846], 'removal': [3427], '16Weaver': [3467], 'propeptide,': [3496, 4204, 5394, 5708], 'lacking': [3499], 'entire': [3501], '102-amino': [3502], 'acid': [3503, 3782, 3871, 5119], 'domain': [3505, 3734, 4036, 4040, 4143, 5049, 5082, 5406], '(SP-BΔC)': [3506], 'baculovirus-infected': [3513, 4882], 'HA': [3520], 'immunoprecipitation': [3530], 'matrix.': [3535], 'immunopurified': [3541, 3760, 4065], 'h': [3545, 3569, 3764], '(pH': [3546, 3570, 3765], '4.7,': [3547], '°C)': [3549, 3768], 'presence': [3552, 5940], 'absence': [3554], 'pepstatin': [3556, 3592], 'inhibitor': [3559, 5677], 'proteinases,': [3562], '6.8,': [3571, 3940], '°C).': [3573], 'showed': [3576, 3790, 3874], 'inhibited': [3590, 5685], '4).': [3595, 3612, 3853], 'similarly': [3598], 'migrated': [3606], '11–12,000': [3610], 'additional': [3614], '28-kDa': [3615], 'band': [3616], 'related': [3623, 5040], 'cross-reactivity': [3625], 'primary': [3628, 4271], 'secondary': [3630], '4,': [3636], 'compare': [3637], '6).': [3642, 3899], 'larger': [3662, 4977], '9000),': [3669], 'indicating': [3670, 4992, 5870], 'Because': [3690, 5133, 5944], 'sufficient': [3691], 'material': [3692], 'obtained': [3695], 'sequencing': [3697], 'site,': [3701], 'SP-B146–207/EGFP': [3724, 3758, 3795, 3857, 3929, 3933, 5094, 5279, 5710], 'included': [3727], '55': [3729], 'saposin-like': [3733, 4035, 5048, 5081], 'first': [3747, 4768], '7': [3748], '5).': [3754, 3780], '6.5,': [3766], '∼33,000': [3778], 'Amino': [3781, 3870], 'analysis': [3784, 3873], 'calculated': [3815], 'molecular': [3816, 4825, 5136], 'mass': [3817, 4826, 5137], 'extension': [3824], '11.1': [3829], 'kDa,': [3830, 5159], 'value': [3832], 'good': [3836], 'agreement': [3837], 'napsin-mediated': [3843, 4257, 5129, 5383, 5480], 'SP-BΔc': [3846, 4878, 4885, 4939, 4966, 5030], 'propeptide.': [3869, 5000, 6379], 'Ala187': [3883, 5730], 'Arg188,': [3885, 5732], 'Thus,': [3900], 'peptide.Fig.': [3926], '6Cleavage': [3927], 'separated': [3950], 'degradation.': [3977], 'GFP,': [3978], 'protein.View': [3981], 'Large': [3982, 4236], 'Image': [3983, 4237], 'Figure': [3984, 4238], 'ViewerDownload': [3985, 4239], 'Hi-res': [3986, 4240], 'image': [3987, 4241], 'Download': [3988, 4242], '(PPT)': [3989, 4243], 'COOH': [4000, 4104, 6230, 6365], 'tested.': [4009], '(SP-B272–298),': [4013], 'consisting': [4014], 'last': [4017], 'eight': [4018], '19': [4027, 4830], '7).': [4050, 4112, 4168], 'SP-B272–298/EGFP': [4051, 4063, 4089], 'same': [4069, 6144], 'conditions': [4070], 'SP-B146–207/EGFP,': [4074], 'result': [4077, 5161, 5493, 5742, 5959], 'protein.': [4083], 'contrast,': [4085, 4170, 5272], 'Met279': [4091], 'Asp280,': [4093], 'demonstrating': [4094], 'further': [4114, 4863], 'could': [4121, 5704], 'positions': [4125], 'we': [4130, 4574, 5906, 6196], 'covering': [4137], 'remainder': [4139], '7,': [4147], 'SP-B294–320/EGFP': [4148, 4174], 'SP-B318–381/EGFP).': [4150], 'proteins.': [4159, 5312], 'Neither': [4160], 'Ala316': [4176], 'Ile317': [4178], 'SP-B318–381/EGFP': [4180], 'Leu349': [4184], 'Val350': [4186], 'second': [4189, 4875], 'time': [4190, 4696], 'His377': [4192], 'Ser378.': [4194], 'summary,': [4196], '8).Fig.': [4223], '8Summary': [4224], 'proprotein.View': [4235], 'Type': [4251], 'Cells—The': [4253], 'biologic': [4254, 5831], 'relevance': [4255, 5832], 'assessed': [4264], 'inhibiting': [4266], 'cultures': [4272, 4779], '9).': [4279, 4341], 'Preliminary': [4280], 'experiments': [4281, 4424, 4754, 5898, 6089, 6187], 'probes': [4285], 'indicated': [4286, 5258], '90%': [4290], 'routinely': [4296], 'reagents.': [4300], 'Five': [4301], 'different': [4302], 'Two': [4314], 'their': [4322, 5487], 'suppress': [4325], 'relative': [4329], 'reagent': [4338], 'alone': [4339], 'siRNA-mediated': [4343, 4383], 'accompanied': [4349, 5864], 'level': [4355], 'after': [4364, 4801, 4835, 5388], 'days': [4366], 'culture.': [4368], 'decreased.': [4377], 'no': [4380], 'cytotoxicity': [4384], '(i.e.': [4385], 'lactate': [4387], 'release),': [4389], '(e.g.': [4396], 'SP-A)': [4397], 'affected': [4400], 'key': [4410], 'attempted': [4427], 'five': [4429, 5273], '40%': [4447], 'those': [4449, 6255], 'cells;': [4452], 'Processing': [4470], 'during': [4474, 6419], 'transit': [4475], 'We': [4485, 4749, 5021, 5930, 6132, 6399], 'have': [4486, 5022, 5490, 5522, 5907, 6072], 'membrane-associated': [4508, 4521], 'proteinase': [4510], 'present': [4572, 4868, 5412], 'study,': [4573, 5413], 'concordance': [4590], 'reports': [4592], 'groups': [4595], '34Brasch': [4615], 'Ochs': [4617, 5327, 5440, 5643, 6262], 'Kahne': [4619, 5329, 5442, 6264], 'Schauer-Vukasinovic': [4623, 5333, 5446, 6268], 'Johnen': [4627, 5337, 5450, 5641, 6272], 'Kapp': [4629, 5339, 5452, 5645, 6274], 'Muller': [4631, 5341, 5454, 5647, 6276], 'K.M.': [4632, 5342, 5455, 5648, 6277], 'Richter': [4633, 5343, 5456, 5653, 6278], 'Hawgood': [4637, 5347, 5460, 6282], '49006-49014Abstract': [4646, 5356, 5469, 6291], '(87)': [4654, 5364, 5477, 6299], 'This': [4657, 4706, 5110, 5741, 5901], 'supports': [4661], 'hypothesis': [4663, 5166], 'addition,': [4675], 'gestation': [4686], '(day': [4699], '17)': [4700], 'previous': [4712], 'weak': [4716], 'mRNA': [4720], '15': [4723], '(18Mori': [4730], 'employed': [4750], 'types': [4752], 'show': [4756], 'capable': [4760], 'cleaving': [4762], 'experiment,': [4769, 4876, 5004], 'fraction': [4786], 'suggesting': [4810, 4945, 5285, 5814], 'Small': [4821], 'amounts': [4822], 'polypeptides': [4827], '(16': [4828], 'kDa)': [4831], 'observed': [4834, 5932], 'forms': [4844], 'polypeptide': [4852], 'Alternatively,': [4855, 5509], 'accumulation': [4856], 'the-25': [4858], 'kDa': [4859], 'facilitate': [4862], 'enzyme(s)': [4867, 6384], 'extract.': [4872], 'transgenic': [4900], '(35Akinbi': [4902], 'Breslin': [4904], 'J.S.': [4905], '272:': [4922], '9640-9647Abstract': [4923], 'When': [4934], 'quality': [4948], 'apparatus': [4950], 'recognized': [4955], 'being': [4960], 'correctly': [4961], 'folded.': [4962], 'generated': [4971], 'slightly': [4976], 'third': [5003], 'coli.': [5020], 'bacteria': [5032], 'insoluble': [5036, 5073], 'likely': [5039, 5535], 'folding': [5044], 'requirements': [5045], 'avoid': [5070], 'refolding': [5071, 5496], 'interval': [5078], '146–207)': [5089], 'EGFP.': [5093], 'Ni-NTA': [5108], '178': [5120], '179,': [5122], 'SP-BΔc.': [5132], 'estimated': [5135], 'glycosylated': [5139], 'SP-B179–381': [5140], '(from': [5141], 'end': [5152], 'peptide)': [5156], '24–25': [5158], 'produces': [5169], 'Previous': [5177], 'analyses': [5178], 'resonance': [5182], 'energy': [5183], 'transfer-based': [5184], 'approach': [5185], 'demonstrated': [5186], 'preference': [5196], 'Leu': [5198], 'position': [5200], 'P1': [5201], '(36Schauer-Vukasinovic': [5202], 'M.B.': [5205], 'Breu': [5206], '1492:': [5214], '207-210Crossref': [5215], '37Gruninger-Leitch': [5221], 'Schlatter': [5223], 'Kung': [5225], 'Nelbock': [5227], 'Dobeli': [5229], '4687-4693Abstract': [5236], '(224)': [5244], 'conform': [5253], 'acids,': [5267], 'Pro179.': [5270], 'Leu-Pro': [5275], 'cleaved,': [5284], 'inaccessible': [5290], 'and/or': [5291], 'neighboring': [5293], 'unfavorable': [5297], 'context': [5298], 'cleavage.': [5300], 'any': [5306], 'peptide-EGFP': [5310], 'differ': [5315], 'recent': [5319], '(34Brasch': [5325, 5438, 6260], 'who': [5367], 'when': [5372], 'refolded': [5378], 'full-length': [5379], 'substrate;': [5382], 'immediately': [5387], 'Val180': [5389], 'Ala184': [5391], 'Ala276': [5395], 'Trp354': [5401], 'domain.': [5431], 'inappropriate': [5495], 'exposure': [5504], 'non-native': [5506], 'differences': [5510], 'contributed': [5523], 'discrepancies': [5526], 'studies.': [5530], 'final': [5545, 5822], 'step': [5546, 5689, 5823], 'like': [5578], '(39Ishii': [5595], 'Hashizume': [5597], 'Kominami': [5599, 5621], 'Uchiyama': [5601, 5623], 'Anat.': [5603], 'Rec.': [5604], '1991;': [5605], '230:': [5606], '519-523Crossref': [5607], '(13)': [5610], '40Yayoi': [5613], 'Ohsawa': [5615], 'Koike': [5617], '89-97Crossref': [5630], '(27)': [5633], '41Brasch': [5636], 'Ten': [5638], 'Brinke': [5639], 'M.F.': [5650], 'Fehrenbach': [5651], 'Batenburg': [5655], '26:': [5666], '659-670Crossref': [5667], 'E-64,': [5674], 'water-soluble': [5676], 'cathepsins': [5679], 'B,': [5680], 'L,': [5682], 'calpain,': [5684], 'distal': [5688], 'i.e.': [5693], 'SP-B9': [5696], 'SP-B8.': [5698], 'substrate': [5716], 'enzyme.': [5719], 'endopeptidase': [5736], 'shows': [5743], 'addition': [5751], 'Interestingly,': [5768], 'contrast': [5770], 'summarized': [5794], 'Fig.': [5796], '8.': [5797], 'domain,': [5813], 'pro-SP-B.': [5829, 5857, 5880], 'cleavages': [5837], 'remains': [5839, 6397], 'unclear.': [5840], 'experiment': [5843], 'cellular': [5854], 'Decreased': [5858], 'knockdown': [5867], 'Accumulation': [5881], '42-kDa': [5884], 'unexpected,': [5904], 'never': [5908], 'able': [5910], '(except': [5917], 'following': [5918], 'injury)': [5920], 'presumably': [5921, 6194], 'rapidly': [5926], 'degraded.': [5929], 'siRNA.': [5943], 'SP-C,': [5952], '5Nogee': [5994], '42Vorbroker': [6039], 'D.K.': [6040], 'Profitt': [6041], 'S.A.': [6042], '268:': [6051], 'L647-L656Crossref': [6052], 'direct': [6057], 'involvement': [6058], 'pro-SP-C': [6062], 'cannot,': [6064], 'excluded': [6067], 'present.': [6069], 'Recent': [6070], 'investigations': [6071], 'can': [6076], 'activate': [6077, 6139], 'interferon': [6079], 'complications': [6083], 'interpretation': [6086], 'such': [6088], '(43Sledz': [6090], 'C.A.': [6091], 'Holko': [6092], 'de': [6094], 'Veer': [6095], 'M.J.': [6096], 'Silverman': [6097], 'R.H.': [6098], 'Williams': [6099], 'Nat.': [6101, 6122], '5:': [6105], '834-839Crossref': [6106], '(1225)': [6109], '38Bridge': [6112], 'A.J.': [6113], 'Pebernard': [6114], 'Ducraux': [6116], 'Nicoulaz': [6118], 'A.L.': [6119], 'Iggo': [6120], 'Genet.': [6123], '34:': [6125], '263-264Crossref': [6126], '(856)': [6129], 'expected': [6137], 'nonspecific': [6140, 6176], 'pathways': [6141], 'extent': [6145], 'negative': [6151], 'control.': [6152], 'Results': [6153], 'relation': [6157], 'Comparable': [6185], 'conclusive,': [6193], 'unable': [6198], 'achieve': [6200], 'inhibition': [6202], 'expression.': [6205], 'Although': [6206], 'it': [6207, 6248], 'possible': [6209], 'vivo,': [6220], 'finding': [6222], 'generates': [6227, 6363], 'exact': [6229], 'argues': [6236], 'relevant': [6243], 'event.': [6245], 'conclusion,': [6247], 'clear': [6250], 'generating': [6309, 6334], 'Our': [6316], 'earlier': [6342], 'identity': [6381], 'responsible': [6385], 'unknown.': [6398], 'thank': [6400], 'Göran': [6401], 'Akusjärvi,': [6402], 'Uppsala': [6403], 'University,': [6404], 'adenovirus': [6406], 'Ettore': [6409], 'Appella,': [6410], 'National': [6411], 'Institutes': [6412], 'Health,': [6414], 'support': [6416], 'discussions': [6418], 'phases': [6422], 'work.': [6425]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2047989123', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 8}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 9}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 9}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 7}, {'year': 2012, 'cited_by_count': 10}], 'updated_date': '2024-12-07T21:36:04.741140', 'created_date': '2016-06-24'}