A Challenge to the Instructive Model of Positive Selection

Name: A Challenge to the Instructive Model of Positive Selection
Uploaded: 1993-10-01

Susan Chan; Christophe Benoist; Diane Mathis

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ID: W2047797295
Title: A Challenge to the Instructive Model of Positive Selection
Abstract: Immunological ReviewsVolume 135, Issue 1 p. 119-131 A Challenge to the Instructive Model of Positive Selection Susan H. Chan, Susan H. Chan Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS et Unité 184 de Biologie Moléculaire de I'INSERM - Institut de Chimie Biologique - 11, rue Humann - 67085 Strasbourg Cédex - France.Search for more papers by this authorCHristophe Benoist, CHristophe Benoist Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS et Unité 184 de Biologie Moléculaire de I'INSERM - Institut de Chimie Biologique - 11, rue Humann - 67085 Strasbourg Cédex - France.Search for more papers by this authorDiane Mathis, Diane Mathis Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS et Unité 184 de Biologie Moléculaire de I'INSERM - Institut de Chimie Biologique - 11, rue Humann - 67085 Strasbourg Cédex - France.Search for more papers by this author Susan H. Chan, Susan H. Chan Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS et Unité 184 de Biologie Moléculaire de I'INSERM - Institut de Chimie Biologique - 11, rue Humann - 67085 Strasbourg Cédex - France.Search for more papers by this authorCHristophe Benoist, CHristophe Benoist Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS et Unité 184 de Biologie Moléculaire de I'INSERM - Institut de Chimie Biologique - 11, rue Humann - 67085 Strasbourg Cédex - France.Search for more papers by this authorDiane Mathis, Diane Mathis Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS et Unité 184 de Biologie Moléculaire de I'INSERM - Institut de Chimie Biologique - 11, rue Humann - 67085 Strasbourg Cédex - France.Search for more papers by this author First published: October 1993 https://doi.org/10.1111/j.1600-065X.1993.tb00646.xCitations: 18AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References Anderson, G., Jenkinson, E. J., Moore, N. C. & Owen, J. T. (1993) MHC class II-positive epithelium and mesenchyme cells are both required for T-cell development in the thymus. Nature 362, 70. Bendelac, A., Matzinger, P., Seder, R. A., Paul, W. E. & Schwartz, R. H. (1992) Activation events during thymic selection. J. Exp. Med. 175, 731. Benoist, C. & Mathis, D. (1989) Positive selection of the T cell repertoire: where and when does it occur Cell 58, 1027. Berg, L., Pullen, A., Fazekas de St., Groth, B., Mathis, D., Benoist, C. & Davis, M. (1989) Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand. Cell 58, 1035. Berg, L. J., Frank, G. D. & Davis, M. M. (1990) The effects of MHC gene dosage and allelic variation on T cell receptor selectin. Cell 60, 1043. Bevan, M. & Fink, P. 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Publication Year: 1993
Publication Date: 1993-10-01
Language: en
Type: review
Indexed In: ['crossref', 'pubmed']

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747, 750, 844, 1113, 1116, 1120, 1207, 1290, 1317, 1320, 1411, 1416, 1484, 1519, 1520, 1560, 1664, 1685, 1739, 1750, 1754, 1783, 1832, 1925, 2050], 'Chan,': [18, 141, 634, 688], 'Chan': [21, 144], 'Laboratoire': [22, 62, 102, 145, 185, 225], 'de': [23, 33, 36, 40, 63, 73, 76, 80, 103, 113, 116, 120, 146, 156, 159, 163, 186, 196, 199, 203, 226, 236, 239, 243, 421], 'Génétique': [24, 64, 104, 147, 187, 227], 'Moléculaire': [25, 35, 65, 75, 105, 115, 148, 158, 188, 198, 228, 238], 'des': [26, 66, 106, 149, 189, 229], 'Eucaryotes': [27, 67, 107, 150, 190, 230], 'du': [28, 68, 108, 151, 191, 231], 'CNRS': [29, 69, 109, 152, 192, 232], 'et': [30, 70, 110, 153, 193, 233], 'Unité': [31, 71, 111, 154, 194, 234], '184': [32, 72, 112, 155, 195, 235], 'Biologie': [34, 74, 114, 157, 197, 237], "I'INSERM": [37, 77, 117, 160, 200, 240], '-': [38, 43, 47, 51, 78, 83, 87, 91, 118, 123, 127, 131, 161, 166, 170, 174, 201, 206, 210, 214, 241, 246, 250, 254], 'Institut': [39, 79, 119, 162, 202, 242], 'Chimie': [41, 81, 121, 164, 204, 244], 'Biologique': [42, 82, 122, 165, 205, 245], '11,': [44, 84, 124, 167, 207, 247], 'rue': [45, 85, 125, 168, 208, 248], 'Humann': [46, 86, 126, 169, 209, 249], '67085': [48, 88, 128, 171, 211, 251], 'Strasbourg': [49, 89, 129, 172, 212, 252], 'Cédex': [50, 90, 130, 173, 213, 253], 'France.Search': [52, 92, 132, 175, 215, 255], 'for': [53, 93, 133, 176, 216, 256, 360, 703, 791, 826, 1395, 1450, 1885, 1934, 2093], 'more': [54, 94, 134, 177, 217, 257], 'papers': [55, 95, 135, 178, 218, 258], 'by': [56, 96, 136, 179, 219, 259, 548, 1130, 1184, 1300, 1329, 1460, 1572, 1577, 1607, 1956, 1996, 2089], 'this': [57, 97, 137, 180, 220, 260, 322], 'authorCHristophe': [58, 181], 'Benoist,': [59, 182, 394, 427, 641, 693, 724, 1906], 'CHristophe': [60, 183], 'Benoist': [61, 184], 'authorDiane': [98, 221], 'Mathis,': [99, 222, 397, 425, 644, 696, 727, 1909], 'Diane': [100, 223], 'Mathis': [101, 224], 'author': [138, 261], 'First': [262], 'published:': [263], 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1033, 1431, 1846], 'your': [325], 'friends': [326], 'colleagues.': [328], 'Learn': [329], 'more.Copy': [330], 'URL': [331], 'Share': [332], 'linkShare': [334], 'onEmailFacebookTwitterLinkedInRedditWechat': [335], 'References': [336], 'Anderson,': [337], 'G.,': [338, 1781, 1979, 2069], 'Jenkinson,': [339], 'E.': [340, 378, 840, 1366], 'J.,': [341, 454, 721, 834, 863, 1080, 1370, 1864, 1897, 1982], 'Moore,': [342], 'N.': [343, 1053, 1082, 1810, 1947, 2043], 'C.': [344, 395, 428, 642, 662, 694, 725, 775, 862, 868, 959, 1020, 1474, 1510, 1547, 1716, 1816, 1907], '&': [345, 379, 396, 429, 458, 482, 508, 537, 562, 589, 616, 643, 665, 695, 726, 748, 785, 809, 841, 870, 909, 942, 972, 1018, 1055, 1083, 1117, 1145, 1176, 1204, 1235, 1261, 1288, 1318, 1349, 1381, 1413, 1444, 1485, 1521, 1561, 1595, 1635, 1661, 1686, 1721, 1751, 1785, 1830, 1870, 1908, 1945, 1986, 2015, 2051, 2076], 'Owen,': [346], 'J.': [347, 389, 531, 561, 580, 603, 630, 667, 682, 865, 894, 937, 970, 1002, 1016, 1039, 1106, 1143, 1190, 1196, 1203, 1234, 1238, 1260, 1264, 1352, 1361, 1372, 1442, 1446, 1483, 1553, 1559, 1625, 1675, 1700, 1859, 1873, 1890, 1989, 2046, 2078, 2096], 'T.': [348, 614, 668, 740], '(1993)': [349, 646, 789, 1208, 1321, 1689, 1911], 'MHC': [350, 447, 466, 521, 732, 1132, 1156, 1915], 'class': [351, 733, 855, 1071, 1157, 1222, 1798, 1916], 'II-positive': [352, 1210], 'epithelium': [353], 'mesenchyme': [355], 'cells': [356, 435, 546, 850, 1065, 1096, 1127, 1186, 1212, 1251, 1423, 1536], 'are': [357, 436, 1358, 1792], 'both': [358], 'required': [359], 'T-cell': [361, 990, 1273, 1302, 1429, 1451, 1732, 1764, 1932], 'development': [362, 1061, 1150], 'in': [363, 442, 523, 597, 624, 766, 795, 822, 851, 982, 995, 1028, 1066, 1099, 1128, 1154, 1221, 1252, 1269, 1387, 1500, 1537, 1647, 1731, 1794, 1877, 2083], 'thymus.': [365, 1254], 'Nature': [366, 551, 931, 955, 966, 1076, 1134, 1275, 1305, 1435, 1467, 1503, 1540, 1650, 1735, 1773, 2005, 2063], '362,': [367], '70.': [368], 'Bendelac,': 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[401, 525, 543, 705, 879, 1101, 1123, 1216, 1298, 1324, 1386, 1529, 1567, 1642, 1670, 1693, 1841, 1928, 1992], 'T': [404, 434, 473, 528, 545, 574, 594, 679, 708, 802, 849, 875, 882, 928, 984, 1064, 1095, 1162, 1185, 1219, 1422, 1498, 1535, 1602, 1623, 1771, 1803, 2061, 2090], 'cell': [405, 474, 529, 876, 929, 947, 985, 1456, 1603, 2003], 'repertoire:': [406], 'where': [407], 'when': [409], 'does': [410, 1334], 'it': [411], 'occur': [412], 'Cell': [413, 449, 477, 656, 736, 804, 829, 1403, 1805, 1920], '58,': [414, 450], '1027.': [415], 'Berg,': [416, 452], 'L.,': [417, 900, 904, 1172, 1778], 'Pullen,': [418, 1552], 'Fazekas': [420], 'St.,': [422], 'Groth,': [423], 'B.,': [424, 776, 1407, 1744, 1817], 'D.,': [426, 638, 687, 715, 717, 745, 1375, 1478, 1514, 1551], 'Davis,': [430, 459, 774, 1170, 1715, 1815], 'M.': [431, 460, 461, 481, 511, 536, 588, 615, 619, 781, 812, 833, 911, 1058, 1086, 1171, 1202, 1237, 1263, 1287, 1597, 1638, 1724, 1829, 1872, 1988], 'Antigen/MHC-specific': [433], 'preferentially': [437], 'exported': [438], 'from': [439, 1187], 'thymus': [441, 489, 1129, 1963, 2082], 'presence': [444], 'their': [446], 'ligand.': [448], '1035.': [451], 'L.': [453, 843, 873, 1174, 1179, 1206, 1315, 1556, 1784, 2011], 'Frank,': [455], 'G.': [456, 811, 869, 1348], '(1990)': [462, 874, 1148, 1239, 1265, 1291, 1565, 2054], 'The': [463, 486, 513, 699, 976, 1354, 1418, 1599, 1927], 'effects': [464], 'gene': [467, 1000, 1026], 'dosage': [468], 'allelic': [470], 'variation': [471], 'on': [472, 492, 1496, 1534], 'receptor': [475, 1098, 1303, 1430, 1495, 1533, 1605, 1765, 1933], 'selectin.': [476], '60,': [478], '1043.': [479], 'Bevan,': [480, 1236, 1262, 1987], 'Fink,': [483], 'P.': [484, 944, 974, 1279, 1309, 1660, 1688, 1780, 2075], '(1978)': [485, 975, 1949, 2079], 'influence': [487], 'H-2': [490, 979, 2087], 'antigens': [491, 1760], 'specificity': [494, 1182], 'maturing': [496], 'killer': [497], 'helper': [499, 680, 983], 'cells.': [500, 550, 709, 828, 1037, 1163, 1624, 1772, 1804, 2062], 'Immunol.': [501, 532, 631, 683, 711, 771, 1040, 1107, 1256, 1340, 1362, 1676, 1701, 1860, 1891, 1936, 2035], 'Rev.': [502], '42,': [503], '3.': [504], 'Bhayani,': [505], 'Hedrick,': [509, 1056, 1084], 'S.': [510, 584, 635, 689, 744, 1050, 1057, 1085, 1412, 1787, 1833, 1981], '(1991)': [512, 566, 669, 729, 752, 845, 1353, 1384, 1598, 1725], 'role': [514, 818, 977], 'polymorphic': [516], 'amino': [517], 'acids': [518], 'molecule': [522], 'repertoire.': [530, 1274], '146,': [533], '1093.': [534], 'Bix,': [535, 2040], 'Raulet,': [538, 783, 2048], 'Inefficient': [541], 'positive': [542, 627, 704, 953, 1215, 1250, 1297, 1323, 1641, 1669, 1840], 'directed': [547], 'haematopoietic': [549], '359,': [552, 2006], '330.': [553], 'Borgulya,': [554], 'Kishi,': [556, 1745], 'H.,': [557, 636, 690, 1139, 1200, 1282, 1378, 1409, 1440, 1746, 1905, 1942], 'Müller,': [558], 'U.,': [559], 'Kirberg,': [560], 'von': [563, 1118, 1376, 1414, 1662, 1683, 1752, 1923, 1940], 'Boehmer,': 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'undergoing': [626], 'Eur.': [629, 1038, 1674, 1699, 1858], '22,': [632, 1677, 1861], '2289.': [633], 'Cosgrove,': [637, 686, 714], 'Waltzinger,': [639, 691], 'Another': [647], 'view': [648], 'selective': [651], 'model': [652, 1394], 'thymocyte': [654, 952, 1301], '73,': [657, 805], '225.': [658], 'Chang,': [659], 'J-F,': [660], 'Thomas,': [661], 'III': [664], 'Kung,': [666], 'Mitogen-induced': [670], 'II-2': [671], 'production': [672], 'proliferation': [674], 'at': [675], 'defined': [676], 'stages': [677], 'differentiation.': [681], '147,': [684, 1363, 2099], '860.': [685], 'compartment': [701], 'responsible': [702], 'CD4+': [707, 759, 848, 1063, 1218], 'Int.': [710, 770, 1255, 1339], '4,': [712, 772], '707.': [713], 'Gray,': [716], 'Dierich,': [718, 1900], 'Kaufman,': [720], 'Lemeur,': [722, 1902], 'Mice': [730, 1912], 'lacking': [731, 1913, 2030], 'II': [734, 1072], 'molecules.': [735, 1133], '66,': [737], '1051.': [738], 'Crompton,': [739], 'Ohashi,': [741, 1278, 1308], 'Schneider,': [743], 'Pircher,': [746, 1281, 1319], 'MacDonald,': [749], 'cortisone': [754], 'sensitive': [755], 'CD3low': [756], 'subset': [757], 'or': [758, 891, 964, 1296, 1400, 1696], 'CD8−': [760], 'represents': [762], 'an': [763, 1392, 1493, 1531], 'intermediate': [764], 'stage': [765], 'intrathymic': [767, 1997], 'repertoire': [768, 1733], '153.': [773], 'Killeen,': [777], 'N.,': [778], 'Casey': [779], 'Crooks,': [780], 'E.,': [782, 1632, 2044], 'Littman,': [786, 1718, 1824], 'Evidence': [790], 'stochastic': [793], 'mechanism': [794], 'differentiation': [797, 1452, 2085], 'mature': [799, 1421, 1622, 1887, 2021], 'subsets': [800, 1246], 'lymphocytes.': [803], '237.': [806], 'Greenwald,': [807], 'I.': [808, 872, 941], 'Rubin,': [810], 'Making': [814], 'difference:': [816], 'cell-cell': [820], 'interactions': [821], 'establishing': [823], 'separate': [824], 'identities': [825], 'equivalent': [827], '68,': [830], '271.': [831, 1505], 'Grusby,': [832, 1201], 'Johnson,': [835], 'S.,': [837, 866, 902, 1114, 1197, 1280, 1310, 1740, 1895, 1975, 2073], 'Papaioannou,': [838], 'V.': [839, 1717, 1899], 'Glimcher,': [842, 1205], 'Depletion': [846], 'major': [852, 1432, 1757], 'histocompatibility': [853, 1433, 1758, 1951], 'complex': [854, 1759], 'II-deficient': [856, 1223], 'mice.': [857, 1189, 1224, 1502, 1539, 1649, 1966], 'Science': [858, 1164], '253,': [859], '1417.': [860], 'Guidos,': [861], 'Danska,': [864], 'Fathman,': [867], 'Weissman,': [871], 'receptor-mediated': [877], 'negative': [878, 1295, 1337, 1528, 1838], 'autoreactive': [881], 'precursors': [884, 1646], 'occurs': [885], 'after': [886], 'commitment': [887, 1396], 'lineages.': [893], '172,': [897], '835.': [898], 'Haughn,': [899], 'Gratton,': [901], 'Caron,': [903], 'Sékaly,': [905], 'R-P.,': [906], 'Veilette,': [907], 'Julius,': [910], 'Association': [913], 'tyrosine': [915, 1855], 'p56lck': [917], 'inhibits': [920], 'induction': [922], 'growth': [924], 'through': [925], 'αβ': [927, 1428, 1763], 'receptor.': [930, 1075], '358,': [932], '328.': [933], 'Hugo,': [934], 'Kappler,': [936, 969, 1142], 'W.,': [938, 1373, 1654, 1680], 'Godfrey,': [939], 'Marrack,': [943, 973, 1140], 'line': [948], 'that': [949, 1333, 1580], 'can': [950], 'induce': [951], '360,': [956], '679.': [957], 'Janeway,': [958], 'Jr.': [961], '(1988)': [962, 1121, 1755, 2018], 'Accessories': [963], 'coreceptors': [965], '335,': [967, 1135, 1504, 1774], '208.': [968], 'linked': [980], 'genes': [981], 'function': [986, 1027], 'IV.': [987], 'importance': [988], 'genotype': [991], 'host': [993], 'environment': [994], 'I': [996, 1158, 1799], 'region': [997, 1092, 1463], 'Ir': [999], 'expression.': [1001], '148,': [1005, 1108], '1510.': [1006], 'Kast,': [1007], 'Woordouw,': [1010], 'Leupers,': [1013], 'T.,': [1014], 'Visser,': [1015], 'W.M.': [1017], 'Melief,': [1019], 'J.M.': [1021], '(1987)': [1022], 'Thymic': [1023, 1385, 1756], 'immune': [1024], 'response': [1025], 'chimeras': [1030], 'as': [1031, 1617], 'reconstituted': [1032], 'purified': [1034], 'hemopoietic': [1035], 'stem': [1036], '17,': [1041], '471.': [1042], 'Kaye,': [1043, 1079], 'I.,': [1044], 'Hsu,': [1045], 'M-L.,': [1046], 'Sauron,': [1047], 'M-E.,': [1048], 'Jameson,': [1049], 'Gascoigne,': [1052], 'R.J.': [1054], 'Selective': [1060, 1490], 'transgenic': [1067, 1327, 1389, 1501, 1538, 1569], 'mice': [1068, 1152, 1390, 1791, 1960, 2057], 'expressing': [1069], 'MHC-restricted': [1073], 'antigen': [1074, 1097, 1494, 1532, 1574, 1604, 1795], '341,': [1077], '746.': [1078], 'Vasquez,': [1081], 'Involvement': [1088], 'same': [1091], 'foreign': [1103], 'peptide': [1104, 1582], 'recognition.': [1105], '3342.': [1109], 'Kisielow,': [1110, 1659, 1687, 1741], 'Teh,': [1112, 1410, 1738, 1831], 'Blüthmann,': [1115, 1408, 1749], 'antigen-specific': [1125], 't': [1126], 'restricting': [1131], '730.': [1136], 'Koller,': [1137], 'B.': [1138, 1351, 1369, 1984, 1985], 'Smithies,': [1146], 'O.': [1147], 'Normal': [1149], 'deficient': [1153, 1793, 2056], 'B2M,': [1155], 'proteins,': [1159], 'CD8+': [1161], '248,': [1165], '1227.': [1166], 'Matis,': [1173], 'Longo,': [1177], '(1984)': [1180], 'Self-recognition': [1181], 'expressed': [1183], 'nude': [1188, 1648], '160,': [1193], '839.': [1194], 'Markowitz,': [1195], 'Auchincloss': [1198], 'Jr.,': [1199], 'Class': [1209], 'hematopoietic': [1211], 'cannot': [1213], 'mediate': [1214], 'lymphocytes': [1220, 1499, 1957], 'Proc.': [1225, 1584, 1967], 'Natl.': [1226, 1585, 1968], 'Acad.': [1227, 1586, 1969], 'Sci.': [1228, 1587, 1970], 'USA': [1229, 1588, 1971], '90,': [1230], '(in': [1231], 'press).': [1232], 'Nikolic-Zugic,': [1233, 1259], 'Functional': [1240], 'phenotypic': [1242], 'delineation': [1243, 1612], 'two': [1245], 'single': [1249], '2,': [1257], '135.': [1258], 'Role': [1266], 'self-peptides': [1268], 'positively': [1270], 'selecting': [1271], '344,': [1276, 2064], '65.': [1277], 'Bürki,': [1283], 'K.,': [1284, 1554, 1592], 'Zinkernagel,': [1285, 1311, 1636, 2066], 'Hengartner,': [1289, 1316], 'Distinct': [1292], 'sequence': [1293], 'implied': [1299], 'densities.': [1304], '346,': [1306], '861.': [1307], 'Leuscher,': [1314], 'Enhanced': [1322], 'TCR': [1328], 'restriction': [1331], 'element': [1332], 'not': [1335], 'permit': [1336], '5,': [1341], '131.': [1342], 'Ramsdell,': [1343, 1379], 'F.,': [1344], 'Jenkins,': [1345], 'Dinh,': [1347], 'Fowlkes,': [1350, 1368], 'majority': [1355], 'CD4+8-thymocytes': [1357], 'functionally': [1359], 'immature.': [1360], '1779.': [1364], 'Robey,': [1365], 'Gordon,': [1371], 'Kioussis,': [1374], 'F.': [1380], 'Axel,': [1382], 'supports': [1391], 'instructive': [1393], 'CDS': [1401], 'lmeage.': [1402], '64,': [1404], '99.': [1405], 'Scott,': [1406, 1743], 'generation': [1419], 'requires': [1424], 'interaction': [1425], 'antigens.': [1434], '338,': [1436], '591.': [1437], 'Seong,': [1438], 'Chamberlain,': [1441], 'Parnes,': [1445], 'Signal': [1449], 'is': [1458, 1575, 1844, 1954], 'delivered': [1459], 'transmembrane': [1462], 'and/or': [1464], 'cytoplasmic': [1465], 'tail.': [1466], '356,': [1468], '718.': [1469], 'Sha,': [1470, 1506, 1543], 'Nelson,': [1473, 1509, 1546], 'Newberry,': [1476, 1512, 1549], 'Kranz,': [1479, 1515], 'Russell,': [1482, 1518, 1558], 'Loh,': [1486, 1522, 1562], 'Y.': [1488, 1524, 1564], '(1988a)': [1489], 'expression': [1491, 1606, 1691, 1876], 'CD8-bearing': [1497], '(1988b)': [1525], '336,': [1541], '73.': [1542], 'Pease,': [1555], 'R.,': [1557, 1826, 2067], 'receptor-bearing': [1570], 'Kb': [1573, 1578], 'altered': [1576], 'mutations': [1579], 'involve': [1581], 'binding.': [1583], '87,': [1589], '6186.': [1590], 'Shortman,': [1591, 2016], 'Vremec,': [1593], 'Egerton,': [1596], 'kinetics': [1600], 'subgroups': [1608], 'CD4+8+': [1610, 1672, 1697], 'thymocytes:': [1611, 2023], 'CD4+Cd8+': [1614], '32+': [1615], 'post-selection': [1618], 'intermediates': [1619], 'leading': [1620], 'lo': [1621], '173,': [1628], '323.': [1629], 'Speiser,': [1630], 'Stübi,': [1633], 'U.': [1634], 'Extrathymic': [1640], 'ab': [1644], 't-cell': [1645], '355,': [1651], '170.': [1652], 'Swat,': [1653, 1679], 'Dessing,': [1655, 1681], 'Baron,': [1657], 'Phenotypic': [1666], 'changes': [1667], 'accompanying': [1668], 'thymocytes.': [1673, 1698], '2367.': [1678], 'CD69': [1690], 'maturation': [1695], '23,': [1702], '739.': [1703], 'The,': [1704], 'H-S.,': [1705], 'Garvin,': [1706, 1812], 'Forbush,': [1709, 1818], 'K.': [1710, 1819, 1948, 2017], 'Carlow,': [1712, 1821], 'Perlmutter,': [1722, 1827], 'Participation': [1726], 'coreceptor': [1729], 'molecules': [1730], '349,': [1736], '241.': [1737], 'Uematsu,': [1747], 'Y.,': [1748], 'determine': [1766], 'CD4/CD8': [1768], 'phenotype': [1769], '229.': [1775], 'van': [1776, 1808], 'Kaer,': [1777], 'Ashton-rickardt,': [1779], 'Ploegh,': [1782, 1904], 'Tonegawa,': [1786], 'TAP1': [1789], 'mutant': [1790], 'presentation,': [1796], 'surface': [1797], 'molecules,': [1800], 'CD4−8+': [1802, 2059], '71,': [1806], '1205.': [1807], 'Oers,': [1809], 'S.C.,': [1811], 'Disruption': [1835], 'CD8-dependent': [1837], 'correlated': [1845], 'decreased': [1848], 'association': [1849], 'between': [1850], 'protein': [1854], 'p56ick.': [1857], '735.': [1862], 'Vernachio,': [1863], 'Li,': [1865], 'Donnenberg,': [1867], 'Soloski,': [1871], 'Qa-2': [1875], 'adult': [1879], 'murine': [1880, 2022], 'thymus:': [1881], 'unique': [1883], 'marker': [1884], 'subset.': [1889], '142,': [1892], '48.': [1893], 'Viville,': [1894], 'Neefjes,': [1896], 'Lotteau,': [1898], 'II-associated': [1917], 'invariant': [1918], 'chain.': [1919], '72,': [1921], '635.': [1922], '(1986)': [1926], 'heterodimeric': [1931], 'antigen.': [1935, 2033], 'Today': [1937], '7,': [1938], '333.': [1939], 'Haas,': [1943], 'Jerne,': [1946], 'Major': [1950], 'complex-linked': [1952], 'immune-responsiveness': [1953], 'acquired': [1955], 'low-responder': [1959], 'differentiating': [1961], 'In': [1962], 'high-responder': [1965], '75,': [1972], '2439.': [1973], 'Vukmanovic,': [1974], 'Grandea': [1976], 'III,': [1977], 'Faas,': [1980], 'Knowles,': [1983], 'T-lymphocytes': [1994], 'induced': [1995], 'injection': [1998], 'epithelial': [2002], 'line.': [2004], '729.': [2007], 'Wilson,': [2008], 'Day,': [2010], 'Scollay,': [2013], 'Subpopulations': [2019], 'properties': [2024], 'CD4−CD8+': [2026], 'CD4+CD8−': [2028], 'heat-stable': [2032], 'Cell.': [2034], '117,': [2036], '312.': [2037], 'Zijlstra,': [2038], 'Simister,': [2042], 'Loring,': [2045], 'Jaenisch,': [2052], 'β2-microglobulin': [2055], 'lack': [2058], 'cytotytic': [2060], '742.': [2065], 'Callahan,': [2068], 'Althage,': [2070], 'Cooper,': [2072], 'Klein,': [2074, 2077], 'On': [2080], 'self-recognition': [2088], 'cells:': [2091], 'evidence': [2092], 'dual': [2094], 'recognition': [2095], '882.': [2100], 'Citing': [2101], 'Literature': [2102], 'Volume135,': [2103], 'Issue1October': [2104], '1993Pages': [2105], 'ReferencesRelatedInformation': [2107]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2047797295', 'counts_by_year': [], 'updated_date': '2024-09-26T15:54:15.767309', 'created_date': '2016-06-24'}

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