Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2047563367', 'doi': 'https://doi.org/10.1111/j.1468-1331.2012.03867.x', 'title': 'White matter volume is decreased in the brain of patients with neuromyelitis optica', 'display_name': 'White matter volume is decreased in the brain of patients with neuromyelitis optica', 'publication_year': 2012, 'publication_date': '2012-09-15', 'ids': {'openalex': 'https://openalex.org/W2047563367', 'doi': 'https://doi.org/10.1111/j.1468-1331.2012.03867.x', 'mag': '2047563367', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/22978568'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/j.1468-1331.2012.03867.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S162635963', 'display_name': 'European Journal of Neurology', 'issn_l': '1351-5101', 'issn': ['1351-5101', '1468-1331'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5010661354', 'display_name': 'Jean‐Baptiste Chanson', 'orcid': 'https://orcid.org/0000-0003-4221-3840'}, 'institutions': [{'id': 'https://openalex.org/I4210145324', 'display_name': 'Hôpitaux Universitaires de Strasbourg', 'ror': 'https://ror.org/04bckew43', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210145324']}, {'id': 'https://openalex.org/I68947357', 'display_name': 'Université de Strasbourg', 'ror': 'https://ror.org/00pg6eq24', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I68947357']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}], 'countries': ['FR'], 'is_corresponding': True, 'raw_author_name': 'J.‐B. Chanson', 'raw_affiliation_strings': ['Département de Neurologie Hôpitaux Universitaires de Strasbourg Strasbourg France', 'Université de Strasbourg and CNRS, LINC, UMR 7237 Strasbourg France'], 'affiliations': [{'raw_affiliation_string': 'Département de Neurologie Hôpitaux Universitaires de Strasbourg Strasbourg France', 'institution_ids': ['https://openalex.org/I4210145324']}, {'raw_affiliation_string': 'Université de Strasbourg and CNRS, LINC, UMR 7237 Strasbourg France', 'institution_ids': ['https://openalex.org/I68947357', 'https://openalex.org/I1294671590']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084045619', 'display_name': 'Julien Lamy', 'orcid': 'https://orcid.org/0000-0002-8400-1400'}, 'institutions': [{'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}, {'id': 'https://openalex.org/I68947357', 'display_name': 'Université de Strasbourg', 'ror': 'https://ror.org/00pg6eq24', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I68947357']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'J. Lamy', 'raw_affiliation_strings': ['Université de Strasbourg and CNRS, LINC, UMR 7237 Strasbourg France'], 'affiliations': [{'raw_affiliation_string': 'Université de Strasbourg and CNRS, LINC, UMR 7237 Strasbourg France', 'institution_ids': ['https://openalex.org/I1294671590', 'https://openalex.org/I68947357']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045707906', 'display_name': 'François Rousseau', 'orcid': 'https://orcid.org/0000-0001-9837-7487'}, 'institutions': [{'id': 'https://openalex.org/I68947357', 'display_name': 'Université de Strasbourg', 'ror': 'https://ror.org/00pg6eq24', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I68947357']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'F. Rousseau', 'raw_affiliation_strings': ['Université de Strasbourg and CNRS, LSIIT, UMR 7005 Strasbourg France'], 'affiliations': [{'raw_affiliation_string': 'Université de Strasbourg and CNRS, LSIIT, UMR 7005 Strasbourg France', 'institution_ids': ['https://openalex.org/I68947357', 'https://openalex.org/I1294671590']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101597826', 'display_name': 'Frédéric Blanc', 'orcid': 'https://orcid.org/0000-0002-6714-3247'}, 'institutions': [{'id': 'https://openalex.org/I4210145324', 'display_name': 'Hôpitaux Universitaires de Strasbourg', 'ror': 'https://ror.org/04bckew43', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210145324']}, {'id': 'https://openalex.org/I68947357', 'display_name': 'Université de Strasbourg', 'ror': 'https://ror.org/00pg6eq24', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I68947357']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'F. Blanc', 'raw_affiliation_strings': ['Département de Neurologie Hôpitaux Universitaires de Strasbourg Strasbourg France', 'Université de Strasbourg and CNRS, LINC, UMR 7237 Strasbourg France'], 'affiliations': [{'raw_affiliation_string': 'Département de Neurologie Hôpitaux Universitaires de Strasbourg Strasbourg France', 'institution_ids': ['https://openalex.org/I4210145324']}, {'raw_affiliation_string': 'Université de Strasbourg and CNRS, LINC, UMR 7237 Strasbourg France', 'institution_ids': ['https://openalex.org/I68947357', 'https://openalex.org/I1294671590']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080131957', 'display_name': 'Nicolas Collongues', 'orcid': 'https://orcid.org/0000-0002-3683-5582'}, 'institutions': [{'id': 'https://openalex.org/I4210145324', 'display_name': 'Hôpitaux Universitaires de Strasbourg', 'ror': 'https://ror.org/04bckew43', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210145324']}, {'id': 'https://openalex.org/I68947357', 'display_name': 'Université de Strasbourg', 'ror': 'https://ror.org/00pg6eq24', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I68947357']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'N. Collongues', 'raw_affiliation_strings': ['Département de Neurologie Hôpitaux Universitaires de Strasbourg Strasbourg France', 'Université de Strasbourg and CNRS, LINC, UMR 7237 Strasbourg France'], 'affiliations': [{'raw_affiliation_string': 'Département de Neurologie Hôpitaux Universitaires de Strasbourg Strasbourg France', 'institution_ids': ['https://openalex.org/I4210145324']}, {'raw_affiliation_string': 'Université de Strasbourg and CNRS, LINC, UMR 7237 Strasbourg France', 'institution_ids': ['https://openalex.org/I68947357', 'https://openalex.org/I1294671590']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022761650', 'display_name': 'Marie Fleury', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210145324', 'display_name': 'Hôpitaux Universitaires de Strasbourg', 'ror': 'https://ror.org/04bckew43', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210145324']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'M. Fleury', 'raw_affiliation_strings': ['Département de Neurologie Hôpitaux Universitaires de Strasbourg Strasbourg France'], 'affiliations': [{'raw_affiliation_string': 'Département de Neurologie Hôpitaux Universitaires de Strasbourg Strasbourg France', 'institution_ids': ['https://openalex.org/I4210145324']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042267999', 'display_name': 'Salem Hannoun', 'orcid': 'https://orcid.org/0000-0002-5982-3242'}, 'institutions': [{'id': 'https://openalex.org/I68947357', 'display_name': 'Université de Strasbourg', 'ror': 'https://ror.org/00pg6eq24', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I68947357']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'J.‐P. Armspach', 'raw_affiliation_strings': ['Université de Strasbourg and CNRS, LINC, UMR 7237 Strasbourg France'], 'affiliations': [{'raw_affiliation_string': 'Université de Strasbourg and CNRS, LINC, UMR 7237 Strasbourg France', 'institution_ids': ['https://openalex.org/I68947357', 'https://openalex.org/I1294671590']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087064021', 'display_name': 'Mériam Koob', 'orcid': 'https://orcid.org/0000-0002-3594-6272'}, 'institutions': [{'id': 'https://openalex.org/I68947357', 'display_name': 'Université de Strasbourg', 'ror': 'https://ror.org/00pg6eq24', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I68947357']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}, {'id': 'https://openalex.org/I4210145324', 'display_name': 'Hôpitaux Universitaires de Strasbourg', 'ror': 'https://ror.org/04bckew43', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210145324']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'S. Kremer', 'raw_affiliation_strings': ['Département de Neuroradiologie Hôpitaux Universitaires de Strasbourg Strasbourg France', 'Université de Strasbourg and CNRS, LINC, UMR 7237 Strasbourg France'], 'affiliations': [{'raw_affiliation_string': 'Université de Strasbourg and CNRS, LINC, UMR 7237 Strasbourg France', 'institution_ids': ['https://openalex.org/I68947357', 'https://openalex.org/I1294671590']}, {'raw_affiliation_string': 'Département de Neuroradiologie Hôpitaux Universitaires de Strasbourg Strasbourg France', 'institution_ids': ['https://openalex.org/I4210145324']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5011213325', 'display_name': 'H. Devilliers', 'orcid': 'https://orcid.org/0000-0002-7197-7578'}, 'institutions': [{'id': 'https://openalex.org/I4210145324', 'display_name': 'Hôpitaux Universitaires de Strasbourg', 'ror': 'https://ror.org/04bckew43', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210145324']}, {'id': 'https://openalex.org/I68947357', 'display_name': 'Université de Strasbourg', 'ror': 'https://ror.org/00pg6eq24', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I68947357']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'J. de Seze', 'raw_affiliation_strings': ['Département de Neurologie Hôpitaux Universitaires de Strasbourg Strasbourg France', 'Université de Strasbourg and CNRS, LINC, UMR 7237 Strasbourg France'], 'affiliations': [{'raw_affiliation_string': 'Département de Neurologie Hôpitaux Universitaires de Strasbourg Strasbourg France', 'institution_ids': ['https://openalex.org/I4210145324']}, {'raw_affiliation_string': 'Université de Strasbourg and CNRS, LINC, UMR 7237 Strasbourg France', 'institution_ids': ['https://openalex.org/I68947357', 'https://openalex.org/I1294671590']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5010661354'], 'corresponding_institution_ids': ['https://openalex.org/I4210145324', 'https://openalex.org/I68947357', 'https://openalex.org/I1294671590'], 'apc_list': {'value': 4940, 'currency': 'USD', 'value_usd': 4940, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 3.431, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 51, 'citation_normalized_percentile': {'value': 0.890078, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '20', 'issue': '2', 'first_page': '361', 'last_page': '367'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10137', 'display_name': 'Diagnosis and Pathogenesis of Multiple Sclerosis', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10137', 'display_name': 'Diagnosis and Pathogenesis of Multiple Sclerosis', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11304', 'display_name': 'Diffusion Magnetic Resonance Imaging', 'score': 0.9918, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12212', 'display_name': 'Diagnosis and Treatment of Primary Central Nervous System Lymphoma', 'score': 0.9852, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/neuromyelitis-optica', 'display_name': 'Neuromyelitis Optica', 'score': 0.612579}, {'id': 'https://openalex.org/keywords/voxel-based-morphometry', 'display_name': 'Voxel-based morphometry', 'score': 0.5700277}, {'id': 'https://openalex.org/keywords/neuroimaging', 'display_name': 'Neuroimaging', 'score': 0.559717}, {'id': 'https://openalex.org/keywords/grey-matter', 'display_name': 'Grey matter', 'score': 0.48199502}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.7941291}, {'id': 'https://openalex.org/C2781172350', 'wikidata': 'https://www.wikidata.org/wiki/Q194520', 'display_name': 'Atrophy', 'level': 2, 'score': 0.7483909}, {'id': 'https://openalex.org/C2781192897', 'wikidata': 'https://www.wikidata.org/wiki/Q822050', 'display_name': 'White matter', 'level': 3, 'score': 0.7223811}, {'id': 'https://openalex.org/C2778183499', 'wikidata': 'https://www.wikidata.org/wiki/Q223851', 'display_name': 'Corpus callosum', 'level': 2, 'score': 0.6568969}, {'id': 'https://openalex.org/C2781137167', 'wikidata': 'https://www.wikidata.org/wiki/Q611458', 'display_name': 'Neuromyelitis optica', 'level': 3, 'score': 0.63068134}, {'id': 'https://openalex.org/C200134340', 'wikidata': 'https://www.wikidata.org/wiki/Q845664', 'display_name': 'Voxel-based morphometry', 'level': 4, 'score': 0.5700277}, {'id': 'https://openalex.org/C2780640218', 'wikidata': 'https://www.wikidata.org/wiki/Q8277', 'display_name': 'Multiple sclerosis', 'level': 2, 'score': 0.5070996}, {'id': 'https://openalex.org/C2778013878', 'wikidata': 'https://www.wikidata.org/wiki/Q646150', 'display_name': 'Grey matter', 'level': 4, 'score': 0.48199502}, {'id': 'https://openalex.org/C146638467', 'wikidata': 'https://www.wikidata.org/wiki/Q10529587', 'display_name': 'Hyperintensity', 'level': 3, 'score': 0.45201075}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.4449444}, {'id': 'https://openalex.org/C2780775167', 'wikidata': 'https://www.wikidata.org/wiki/Q9606', 'display_name': 'Spinal cord', 'level': 2, 'score': 0.44375107}, {'id': 'https://openalex.org/C164705383', 'wikidata': 'https://www.wikidata.org/wiki/Q10379', 'display_name': 'Cardiology', 'level': 1, 'score': 0.38706616}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.37431842}, {'id': 'https://openalex.org/C143409427', 'wikidata': 'https://www.wikidata.org/wiki/Q161238', 'display_name': 'Magnetic resonance imaging', 'level': 2, 'score': 0.36317277}, {'id': 'https://openalex.org/C126838900', 'wikidata': 'https://www.wikidata.org/wiki/Q77604', 'display_name': 'Radiology', 'level': 1, 'score': 0.22767338}, {'id': 'https://openalex.org/C118552586', 'wikidata': 'https://www.wikidata.org/wiki/Q7867', 'display_name': 'Psychiatry', 'level': 1, 'score': 0.08345556}], 'mesh': [{'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D009413', 'descriptor_name': 'Nerve Fibers, Myelinated', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D009471', 'descriptor_name': 'Neuromyelitis Optica', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001284', 'descriptor_name': 'Atrophy', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D001284', 'descriptor_name': 'Atrophy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016022', 'descriptor_name': 'Case-Control Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003711', 'descriptor_name': 'Demyelinating Diseases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003711', 'descriptor_name': 'Demyelinating Diseases', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D003711', 'descriptor_name': 'Demyelinating Diseases', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008279', 'descriptor_name': 'Magnetic Resonance Imaging', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009103', 'descriptor_name': 'Multiple Sclerosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009103', 'descriptor_name': 'Multiple Sclerosis', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D009103', 'descriptor_name': 'Multiple Sclerosis', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D009413', 'descriptor_name': 'Nerve Fibers, Myelinated', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D009413', 'descriptor_name': 'Nerve Fibers, Myelinated', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D036421', 'descriptor_name': 'Nerve Fibers, Unmyelinated', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D036421', 'descriptor_name': 'Nerve Fibers, Unmyelinated', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D036421', 'descriptor_name': 'Nerve Fibers, Unmyelinated', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D059906', 'descriptor_name': 'Neuroimaging', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009471', 'descriptor_name': 'Neuromyelitis Optica', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D009471', 'descriptor_name': 'Neuromyelitis Optica', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014792', 'descriptor_name': 'Visual Acuity', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D014792', 'descriptor_name': 'Visual Acuity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/j.1468-1331.2012.03867.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S162635963', 'display_name': 'European Journal of Neurology', 'issn_l': '1351-5101', 'issn': ['1351-5101', '1468-1331'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/22978568', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.66, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 20, 'referenced_works': ['https://openalex.org/W1752370729', 'https://openalex.org/W1975385248', 'https://openalex.org/W1994683739', 'https://openalex.org/W2034957520', 'https://openalex.org/W2041820375', 'https://openalex.org/W2049893954', 'https://openalex.org/W2050360242', 'https://openalex.org/W2054304557', 'https://openalex.org/W2071881327', 'https://openalex.org/W2072110415', 'https://openalex.org/W2097557265', 'https://openalex.org/W2106399688', 'https://openalex.org/W2107085924', 'https://openalex.org/W2122545833', 'https://openalex.org/W2124851812', 'https://openalex.org/W2136132690', 'https://openalex.org/W2138427089', 'https://openalex.org/W2145192775', 'https://openalex.org/W2159557609', 'https://openalex.org/W2161197854'], 'related_works': ['https://openalex.org/W2701934057', 'https://openalex.org/W2419296788', 'https://openalex.org/W2393212393', 'https://openalex.org/W2277556599', 'https://openalex.org/W2149940328', 'https://openalex.org/W2125358722', 'https://openalex.org/W2098924721', 'https://openalex.org/W2082094717', 'https://openalex.org/W1602287720', 'https://openalex.org/W1562573443'], 'abstract_inverted_index': {'Neuromyelitis': [0], 'optica': [1], '(NMO)': [2], 'is': [3], 'an': [4, 152, 159, 236], 'inflammatory': [5], 'disease': [6, 89], 'involving': [7], 'predominantly': [8], 'the': [9, 106, 145, 187], 'spinal': [10, 250], 'cord': [11, 251], 'and': [12, 42, 50, 72, 77, 93, 157, 164, 205, 212, 220, 252], 'optic': [13, 206, 253], 'nerves.': [14], 'Whether': [15], 'patients': [16, 33, 45, 52, 84, 119], 'with': [17, 34, 46, 53, 85, 120, 148], 'NMO': [18, 83, 121, 182], 'have': [19], 'a': [20, 54, 63, 99, 197, 213, 229], 'loss': [21, 110], 'in': [22, 82, 118, 178, 181, 186, 233], 'white': [23, 69], 'or': [24], 'grey': [25], 'matter': [26, 70, 113], '(GM)': [27], 'volumes': [28, 74], 'remains': [29], 'to': [30, 104, 128, 243, 246], 'be': [31, 244], 'determined.Thirty': [32], 'NMO,': [35, 234], '30': [36], 'healthy': [37, 129], 'subjects': [38, 130], 'matched': [39], 'for': [40, 144], 'age': [41], 'gender,': [43, 87], '21': [44], 'multiple': [47], 'sclerosis': [48], '(MS)': [49], '20': [51], 'clinically': [55], 'isolated': [56], 'syndrome': [57], '(CIS)': [58], 'were': [59], 'studied.': [60], 'We': [61, 67, 96, 166], 'applied': [62], 'SIENAX': [64], 'post-treatment': [65], 'software.': [66], 'compared': [68, 127], '(WM)': [71], 'GM': [73, 217], 'between': [75], 'groups': [76], 'explored': [78], 'correlations': [79], 'of': [80, 111, 155, 161, 173, 189, 200, 216, 238], 'changes': [81], 'age,': [86], 'duration,': [88], 'severity,': [90], 'visual': [91], 'acuity': [92], 'T2': [94], 'hyperintensities.': [95], 'also': [97, 150], 'performed': [98], 'voxel-based': [100], 'morphometry': [101], '(VBM)': [102], 'analysis': [103, 195], 'identify': [105], 'regions': [107, 199, 215], 'affected': [108], 'by': [109], 'volume.White': [112], 'volume': [114, 180], 'was': [115, 142, 183], 'significantly': [116], 'reduced': [117], '(764.4': [122], '±': [123, 132], '58.3': [124], 'cm(3)': [125, 134], ')': [126, 135], '(843.1': [131], '49.3': [133], '(P': [136], '<': [137, 209, 224], '0.001),': [138], 'whereas': [139], 'no': [140], 'difference': [141], 'observed': [143], 'GM.': [146, 165], 'Patients': [147], 'CIS': [149], 'presented': [151], 'elective': [153], 'atrophy': [154, 160, 202, 218], 'WM': [156, 163, 179, 201, 239], 'MS': [158], 'both': [162], 'did': [167], 'not': [168, 242], 'find': [169], 'any': [170], 'predictive': [171], 'factors': [172], 'brain': [174, 231], 'atrophy.': [175], 'The': [176, 193], 'decrease': [177], 'noted': [184], 'even': [185], 'absence': [188], 'visible': [190], 'MRI': [191], 'hypersignals.': [192], 'VBM': [194], 'found': [196], 'few': [198, 214], '(corpus': [203], 'callosum': [204], 'radiations,': [207], 'P': [208, 223], '0.005,': [210], 'uncorrected)': [211], '(thalamus': [219], 'prefrontal': [221], 'cortex,': [222], '0.001,': [225], 'uncorrected).These': [226], 'results': [227], 'suggest': [228], 'significant': [230], 'involvement': [232, 237], 'especially': [235], 'which': [240], 'appears': [241], 'limited': [245], 'secondary': [247], 'degeneration': [248], 'after': [249], 'nerve': [254], 'damage.': [255]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2047563367', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 9}, {'year': 2014, 'cited_by_count': 7}, {'year': 2013, 'cited_by_count': 1}], 'updated_date': '2024-08-31T19:17:31.270453', 'created_date': '2016-06-24'}