Ryanodine Receptor Type I and Nicotinic Acid Adenine Dinucleotide Phosphate Receptors Mediate Ca2+ Release from Insulin-containing Vesicles in Living Pancreatic β-Cells (MIN6)

Name: Work Video:
Duration: 3 min 30 s
Kathryn J. Mitchell; F. Anthony Lai; Guy A. Rutter
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253, 718, 784, 903, 948, 1518, 1615, 1854, 1952, 2028, 2530, 3015, 3200, 3921, 4057], 'Biol.': [26, 254, 541, 617, 639, 719, 785, 803, 827, 904, 949, 1084, 1131, 1161, 1213, 1234, 1301, 1445, 1504, 1519, 1855, 1920, 1953, 2029, 2047, 2368, 2906, 3016, 3201, 3227, 3243, 3262, 3306, 3364, 4058, 4090, 4234, 4251, 4443, 4456], '155,': [27, 255], '41–51)': [28, 256], 'that': [29, 42, 207, 257, 270, 435, 753, 910, 1348, 1646, 1660, 1736, 1748, 2671, 3885, 3969, 4258, 4277, 4319, 4354, 4375, 4405], 'ryanodine': [30, 258, 482, 1632, 4075], 'receptors': [31, 259, 923, 1737], '(RyR)': [32, 260], 'are': [33, 261, 1356, 1556, 1670, 1755, 2199, 4173], 'present': [34, 262, 1062, 1642, 1671, 3890], 'on': [35, 136, 263, 364, 570, 1689, 1715, 1730, 2260, 2775, 2829, 2835, 2846, 3376, 3863, 3891, 3990, 3998, 4014, 4362, 4413, 4429, 4534], 'insulin-containing': [36, 264], 'secretory': [37, 68, 115, 154, 214, 265, 296, 343, 382, 442, 464, 756, 809, 927, 1462, 1705, 1749, 1932, 3845, 3892, 3897, 3910, 3981, 4107, 4283, 4340, 4414], 'vesicles.': [38, 266], 'Here': [39, 267], 'we': [40, 205, 268, 433, 748, 1644, 1745, 4017, 4400], 'show': [41, 269, 1645], 'pancreatic': [43, 271, 519], 'islets': [44, 272, 1139, 1201, 1355, 1608, 1647], 'derived': [46, 274, 1252], 'β-cell': [47, 275, 1769], 'lines': [48, 276, 2059], 'express': [49, 277, 1651], 'type': [50, 56, 78, 278, 284, 306, 995, 1109, 1667, 3830, 3974, 4262, 4267, 4292, 4359, 4370], 'I': [51, 79, 107, 279, 307, 335, 996, 1279, 1656, 1668, 2121, 2346, 2392, 2820, 2875, 3664, 3746, 3766, 3831, 3887, 3937, 4010, 4195, 4293, 4336, 4371, 4425], 'II,': [53, 281, 1659, 3749, 4268], 'but': [54, 87, 156, 282, 315, 384, 912, 1707, 1751, 3986, 4198, 4264, 4521, 4529], 'not': [55, 157, 283, 385, 913, 1597, 1708, 1752, 2477, 3680, 3688, 3792, 4199, 4265, 4377], 'III,': [57, 285], 'RyRs.': [58, 286], 'Purified': [59, 287], 'by': [60, 218, 288, 446, 2238, 2246, 2258, 2471, 2516, 2551, 2614, 2731, 2811, 2844, 2946, 3314, 3498, 3604, 3722, 3727, 4034, 4168, 4549], 'subcellular': [61, 289, 1663, 3810, 4320], 'fractionation': [62, 290, 3811, 3966], 'membrane': [64, 292, 487, 573, 2591, 2793, 2832, 2856], 'immuno-isolation,': [65, 293], 'dense': [66, 152, 294, 380, 754, 1460, 3908], 'core': [67, 153, 295, 381, 755, 1461, 3844, 3909], 'vesicles': [69, 297, 757, 810, 928, 1463, 1706, 1716, 1933, 2520, 2569, 3893, 3911, 3982, 4284], 'were': [70, 298, 1401, 1572, 1794, 1880, 1894, 1997, 2236, 2256, 2267, 2486, 2543, 2570, 2594, 2612, 2695, 2773, 2787, 2842, 2863, 2942, 3055, 3093, 3142, 3156, 3208, 3374, 3478, 3494, 3527, 3542, 3580, 3602, 3669, 3782, 4063, 4462], 'found': [71, 299], 'to': [72, 122, 195, 300, 350, 423, 842, 1096, 1890, 1929, 2068, 2088, 2280, 2565, 2584, 2659, 2790, 3075, 3139, 3171, 3385, 3468, 3662, 3796, 3933, 3955, 4031, 4065, 4079, 4081, 4142, 4183, 4186, 4287, 4334, 4387, 4476, 4555], 'possess': [73, 301], 'a': [74, 147, 175, 302, 375, 403, 557, 760, 812, 854, 1064, 1435, 1546, 1677, 1694, 1718, 1764, 1831, 1983, 2000, 2191, 2261, 2272, 2378, 2660, 2776, 2799, 2859, 3067, 3076, 3159, 3335, 3377, 3386, 3394, 3423, 3591, 3824, 3934, 4020, 4300, 4338, 4373, 4469, 4519, 4550], 'similar': [75, 303, 3836, 4554], 'level': [76, 304], 'of': [77, 105, 169, 225, 305, 333, 397, 453, 498, 515, 559, 563, 606, 815, 819, 857, 877, 1066, 1243, 1277, 1341, 1548, 1562, 1697, 1717, 1724, 1728, 1985, 1987, 1994, 2093, 2095, 2143, 2146, 2155, 2161, 2167, 2176, 2194, 2240, 2248, 2309, 2318, 2324, 2330, 2339, 2381, 2494, 2518, 2664, 2783, 2801, 2816, 2944, 3152, 3179, 3292, 3319, 3323, 3339, 3346, 3348, 3442, 3456, 3462, 3470, 3473, 3496, 3538, 3640, 3713, 3715, 3805, 3818, 3838, 3973, 3994, 4008, 4037, 4074, 4083, 4101, 4350, 4358, 4390, 4422, 4431, 4471, 4544], 'RyR': [80, 90, 106, 208, 308, 318, 334, 436, 985, 1034, 1059, 1090, 1244, 1278, 1281, 1349, 1394, 1628, 1653, 1655, 1658, 1683, 1698, 2098, 2120, 2126, 2133, 2345, 2348, 2391, 2426, 2661, 2686, 2819, 2826, 2868, 3663, 3666, 3684, 3702, 3745, 3748, 3765, 3778, 3826, 3839, 3856, 3872, 3886, 3956, 4009, 4012, 4085, 4269, 4335, 4424], 'immunoreactivity': [81, 309, 3840, 3858, 3888, 4333], 'as': [82, 310, 556, 735, 1196, 1198, 2008, 2118, 2200, 2389, 2703, 2746, 3061, 3143, 3217, 3709, 4337, 4396], 'Golgi/endoplasmic': [83, 311], 'reticulum': [84, 312, 472, 625], '(ER)': [85, 313, 626], 'membranes': [86, 314, 3947, 4325], 'substantially': [88, 316, 4096], 'less': [89, 317, 1359], 'II': [91, 319, 1035, 1091, 1245, 1350, 1395, 1684, 2127, 2349, 2427, 2687, 2880, 3667, 3779, 3857, 3873, 3976, 4013, 4360], 'than': [92, 320, 1360, 1404, 3419, 3772, 3787, 3983, 4369], 'the': [93, 114, 223, 321, 342, 451, 513, 548, 571, 604, 674, 816, 844, 1039, 1073, 1098, 1104, 1241, 1338, 1362, 1560, 1565, 1623, 1627, 1641, 1710, 1713, 1726, 1753, 1931, 1959, 2069, 2096, 2241, 2249, 2252, 2304, 2463, 2546, 2618, 2684, 2698, 2817, 3146, 3150, 3173, 3180, 3287, 3327, 3349, 3448, 3465, 3471, 3474, 3486, 3500, 3636, 3651, 3694, 3716, 3735, 3798, 3802, 3864, 3875, 3895, 3970, 3984, 3991, 3995, 4005, 4035, 4098, 4106, 4112, 4122, 4261, 4266, 4309, 4328, 4355, 4363, 4381, 4403, 4420, 4432, 4542], 'latter.': [94, 322], 'Monitored': [95, 323], 'in': [96, 113, 162, 179, 324, 341, 390, 407, 490, 500, 553, 678, 736, 762, 765, 929, 992, 1003, 1038, 1063, 1107, 1199, 1251, 1288, 1343, 1361, 1398, 1405, 1545, 1564, 1575, 1599, 1622, 1676, 1681, 1704, 1709, 1760, 1796, 1830, 2303, 2462, 2468, 2580, 2596, 2675, 2960, 3046, 3066, 3072, 3108, 3145, 3158, 3169, 3281, 3286, 3326, 3334, 3502, 3507, 3530, 3544, 3560, 3769, 3773, 3785, 3788, 3807, 3841, 3874, 3894, 3945, 3980, 4023, 4070, 4104, 4174, 4270, 4305, 4311, 4465, 4479, 4525], 'cells': [97, 325, 1222, 1309, 1550, 1879, 2480, 2539, 2593, 3054, 3092, 3155, 3207, 3373, 3501, 3541, 3579, 4467], 'expressing': [98, 326], 'appropriately': [99, 327], 'targeted': [100, 328, 1928, 4029], 'aequorins,': [101, 329, 4028], 'dantrolene,': [102, 330, 1693], 'an': [103, 331, 1453, 1756, 2090, 2933, 3343, 4397], 'inhibitor': [104, 332, 1696], 'channels,': [108, 336], 'elevated': [109, 337], 'free': [110, 159, 338, 387, 456, 459, 463, 879, 1702, 4067, 4102], 'Ca2+': [111, 138, 160, 173, 177, 211, 339, 366, 388, 401, 405, 439, 461, 466, 492, 564, 568, 607, 610, 676, 859, 880, 1457, 1543, 1570, 1594, 1638, 1731, 1758, 2945, 3168, 3492, 3497, 4068, 4103, 4280, 4407], 'concentrations': [112, 161, 340, 389, 4069, 4100], 'vesicle': [116, 155, 344, 383, 465, 485, 2512, 2586, 2634, 3846, 4108], 'compartment': [117, 345], 'from': [118, 174, 213, 346, 402, 441, 518, 608, 926, 1459, 1602, 2057, 2251, 2289, 2647, 2683, 3672, 3690, 3704, 4282, 4308], '40.1': [119, 347, 4139], '±': [120, 124, 192, 348, 352, 420, 3638, 4140, 4144], '6.7': [121, 349, 4141], '90.4': [123, 351, 4143], '14.8': [125, 353, 4145], 'μm(n': [126, 354], '=': [127, 200, 355, 428, 4148], '4,': [128, 356], 'p': [129, 202, 357, 430], '<': [130, 203, 358, 431, 4150], '0.01),': [131, 204, 359, 432], 'while': [132, 360], 'having': [133, 361], 'no': [134, 196, 362, 424, 3988], 'effect': [135, 363, 4533], 'ER': [137, 158, 365, 386, 460, 1690, 1960, 3985, 4113, 4310, 4324, 4364], 'concentrations.': [139, 367], 'Furthermore,': [140, 368], 'nicotinic': [141, 369, 477, 1429], 'acid': [142, 370, 478, 1430, 2812, 2957], 'adenine': [143, 371, 479, 1431], 'dinucleotide': [144, 372, 480, 1432], 'phosphate': [145, 373, 481, 1433], '(NAADP),': [146, 374, 1434], 'novel': [148, 376, 1436], 'Ca2+-mobilizing': [149, 377, 1438, 4435], 'agent,': [150, 378], 'decreased': [151, 379], 'permeabilized': [163, 391, 3094, 4466], 'MIN6': [164, 181, 392, 409, 1649, 1762, 2479, 2538, 2590, 3206, 3540, 3808, 3820, 4025, 4271, 4312], 'β-cells,': [165, 393, 3809], 'flash': [167, 395], 'photolysis': [168, 396, 3455], 'caged': [170, 398, 3295, 3324, 3457], 'NAADP': [171, 399, 1563, 1739, 3296, 3325, 3458, 4437, 4517, 4545], 'released': [172, 400], 'thapsigargin-insensitive': [176, 404], 'store': [178, 406, 856, 1759], 'single': [180, 408], 'cells.': [182, 410, 4026], 'Because': [183, 411], 'dantrolene': [184, 412, 4126, 4180, 4259], 'strongly': [185, 413], 'inhibited': [186, 414], 'glucose-stimulated': [187, 415], 'insulin': [188, 226, 416, 454, 516, 3601], 'secretion': [189, 417, 517], '(from': [190, 418, 4138], '3.07': [191, 419], '0.51-fold': [193, 421], 'stimulation': [194, 422, 497], 'significant': [197, 425, 4523], 'glucose': [198, 426, 1805, 3553, 3589], 'effect;n': [199, 427], '3,': [201, 429], 'conclude': [206, 434], 'I-mediated': [209, 437], 'Ca2+-induced': [210, 438], 'release': [212, 440, 605, 1544, 1595, 4408], 'vesicles,': [215, 443, 1750, 4415], 'possibly': [216, 444], 'potentiated': [217, 445], 'NAADP,': [219, 447], 'is': [220, 448, 1000, 1036, 1061, 2672, 4285, 4353, 4365], 'essential': [221, 449], 'for': [222, 450, 496, 512, 1428, 1456, 1738, 2204, 2211, 2216, 2221, 2224, 2231, 2396, 2403, 2408, 2413, 2416, 2423, 2431, 2438, 2443, 2448, 2451, 2458, 2577, 2623, 2638, 2992, 3040, 3099, 3177, 3437, 3454, 3523, 3554, 3566, 3590, 3744, 3871], 'activation': [224, 452, 514], 'secretion.': [227, 455], 'cytosolic': [457, 2652], 'Ca2+concentration': [458], 'concentration': [462, 467, 493, 881, 3322, 3338, 4470], 'cyclic': [468, 1634], 'ADP': [469], 'ribose': [470], 'endoplasmic': [471, 624], 'enhanced': [473, 2934], 'green': [474], 'fluorescent': [475], 'protein': [476, 488, 1246, 1396, 2513, 2566, 2827, 2836], 'receptor': [483, 4551], 'aequorin': [484, 1905, 1927, 1995, 3175, 3181], 'associated': [486], 'Increases': [489], 'cytoplasmic': [491], '([Ca2+]c)1are': [494], 'important': [495], 'neurosecretion': [499], 'general': [501], '(1Rutter': [502, 522], 'G.A.': [503, 523, 716, 727, 782, 801, 901, 946, 957, 1852, 1865, 1950, 2026, 2035, 2528, 3013, 3198, 3221, 3241, 3260, 3354, 3611, 3625, 3919, 4055], 'Mol.': [504, 524, 596], 'Aspects': [505, 525], 'Med.': [506, 526], '2001;': [507, 527, 720, 786, 905, 950, 1473, 1536, 1856, 1954, 2030, 3017, 3202, 4059, 4223, 4253, 4511], '22:': [508, 528], '247-284Google': [509, 529], 'Scholar)': [510, 601, 656, 671, 734, 837, 908, 1136, 1218, 1306, 1539, 1791, 1925, 1957, 2117, 3039, 3311, 4095, 4134, 4461, 4496], 'islet': [520, 3786], 'β-cells': [521, 679, 766, 820, 930, 1254, 1344, 1400, 1577, 1601, 1650, 4481], 'Scholar,2Wollheim': [530], 'C.B.': [531, 613, 693, 2041], 'Blondel': [532], 'B.': [533, 1021, 1172, 1369, 1612, 3235], 'Trueheart': [534], 'P.A.': [535, 968], 'Renold': [536], 'A.E.': [537, 795, 3252], 'Sharp': [538], 'G.W.': [539, 1514], 'J.': [540, 595, 616, 637, 667, 694, 717, 783, 825, 868, 902, 947, 1042, 1083, 1130, 1160, 1212, 1233, 1300, 1444, 1492, 1517, 1772, 1853, 1914, 1919, 1951, 1969, 1977, 2027, 2046, 2113, 2367, 2529, 2721, 2764, 2905, 3014, 3035, 3085, 3199, 3242, 3261, 3305, 3629, 3920, 4056, 4089, 4221, 4233, 4250, 4442, 4455], 'Chem.': [542, 618, 1085, 1132, 1162, 1214, 1235, 1302, 1446, 1921, 2048, 2369, 2907, 3244, 3263, 3307, 3363, 4091, 4235, 4252, 4444, 4457], '1975;': [543, 828], '250:': [544], '1354-1360Google': [545], 'Scholar).': [546, 622, 746, 807, 872, 981, 1058, 1089, 1239, 1274, 1426, 1476, 1620, 1870, 2052, 2535, 2768, 2911, 3020, 3089, 3205, 3368, 3616, 3633, 3926, 4514], 'In': [547, 1640, 2536, 3794, 4120], 'latter': [549, 1624, 3865], 'cell': [550, 738, 1069, 1552, 2058, 3351, 3466, 3821, 4500], 'type,': [551], 'increases': [552], '[Ca2+]cusually': [554], 'occur': [555], 'result': [558, 4315], 'either': [560, 1603, 1930, 2822, 3999, 4032], 'nutrient-induced': [561], 'influx': [562], 'ions': [565, 860], 'through': [566], 'voltage-gated': [567], 'channels': [569], 'plasma': [572, 2641], '(3Safayhi': [574], 'H.': [575, 577, 628, 1050, 1129, 1159, 1180, 1377, 1778, 4219], 'Haase': [576, 631], 'Kramer': [578], 'U.': [579, 975, 1026, 1189, 1386, 1586, 4490], 'Bihlmayer': [580], 'Roenfeldt': [582], 'M.': [583, 587, 647, 649, 866, 966, 1015, 1048, 1117, 1147, 1209, 1230, 1297, 1908, 1963, 1965, 2039, 2362, 2364], 'Ammon': [584], 'H.P.': [585], 'Froschmayr': [586], 'Cassidy': [588], 'T.N.': [589], 'Morano': [590], 'I.': [591, 636, 1125, 1155, 1170, 1367, 1510, 2103, 3237], 'Ahlijanian': [592], 'M.K.': [593], 'Striessnig': [594], 'Endocrinol.': [597, 1330], '1997;': [598, 834, 3245, 3308, 4236], '11:': [599], '619-629Google': [600], 'or': [602, 1605, 1721, 1900, 1926, 1958, 2060, 2245, 2294, 2347, 2481, 2834, 2927, 3290, 3675, 4331, 4553], 'via': [603, 4291], 'intracellular': [609, 763, 817, 1437, 3109, 3337, 3803], 'stores': [611, 677, 1571, 3493], '(4Wollheim': [612], 'Biden': [614], 'T.J.': [615, 1178, 1375, 2101, 2900, 3083], '1986;': [619, 4092], '261:': [620, 4093], '8314-8319Google': [621], 'The': [623, 994, 2139, 3321, 3572, 3711, 3964, 4273, 4427], '(5Streb': [627], 'Bayerdorffer': [629], 'W.': [632, 1260, 1412], 'Irvine': [633], 'R.F.': [634], 'Schulz': [635], 'Membr.': [638], '1984;': [640], '81:': [641], '241-253Google': [642], 'Scholar,': [643, 700, 723, 789, 953, 964, 1166, 1490, 1508, 1523, 1859, 2033, 3231, 3248, 4211, 4226, 4239, 4448], '6Rizzuto': [644], 'R.': [645, 665, 683, 714, 780, 899, 944, 1258, 1325, 1410, 1443, 1850, 1910, 1918, 1948, 1967, 1971, 1975, 2024, 2045, 3011, 3196, 3258, 3300, 4053, 4441], 'Brini': [646, 1964], 'Murgia': [648, 2038], 'Pozzan': [650, 662, 690, 711, 777, 896, 941, 1847, 1915, 1945, 1972, 2021, 2042, 3008, 3193, 4050], 'T.': [651, 663, 691, 712, 778, 897, 942, 1044, 1113, 1127, 1143, 1157, 1311, 1780, 1848, 1916, 1946, 1973, 2022, 2043, 3009, 3194, 3304, 4051], 'Science.': [652, 4130, 4207], '1993;': [653, 2049, 3036], '262:': [654], '744-747Google': [655], 'Golgi': [658, 2644], 'apparatus': [659], '(7Pinton': [660], 'P.': [661, 704, 770, 832, 889, 934, 1009, 1264, 1416, 1494, 1840, 1938, 2014, 3001, 3186, 4043, 4243], 'Rizzuto': [664, 682, 713, 779, 898, 943, 1849, 1917, 1947, 1974, 2023, 2044, 3010, 3195, 3257, 4052], 'EMBO': [666, 1976], '1998;': [668, 1133, 1163, 1192, 1389, 3365], '17:': [669], '5298-5308Google': [670], 'probably': [672], 'represent': [673, 1452, 3635], 'major': [675], '(8Kennedy': [680], 'E.D.': [681], 'Theler': [684, 2036], 'J.M.': [685, 1481, 2037, 3225, 3362], 'Pralong': [686, 1259, 1411], 'W.F.': [687], 'Bastianutto': [688, 1911], 'C.': [689, 708, 774, 893, 938, 1017, 1844, 1863, 1912, 1942, 2018, 2709, 2752, 3005, 3190, 3609, 4047], 'Wollheim': [692, 2040], 'Clin.': [695], 'Invest.': [696], '1996;': [697, 978, 1332, 2722, 2765], '98:': [698], '2524-2538Google': [699], '9Mitchell': [701], 'K.J.': [702, 768, 887, 932, 1838, 1936, 2012, 2999, 3184, 4041], 'Pinton': [703, 769, 888, 933, 1839, 1937, 2013, 3000, 3185, 4042], 'Varadi': [705, 771, 890, 935, 1841, 1939, 2015, 3002, 3187, 4044], 'Tacchetti': [707, 773, 892, 937, 1843, 1941, 2017, 3004, 3189, 4046], 'Ainscow': [709, 775, 894, 939, 1845, 1943, 2019, 2523, 3006, 3191, 3253, 3914, 4048], 'E.K.': [710, 776, 824, 895, 940, 1846, 1861, 1944, 2020, 2524, 3007, 3192, 3254, 3607, 3915, 4049], 'Rutter': [715, 726, 781, 800, 900, 945, 956, 1851, 1864, 1949, 2025, 2527, 3012, 3197, 3240, 3259, 3610, 3918, 4054], '155:': [721, 787, 906, 951, 1857, 1955, 2031, 3018, 3203, 4060], '41-51Google': [722, 788, 907, 952, 1858, 1956, 2032, 3019, 3204, 4061], '10Varadi': [724, 954], 'Diabetes.': [728, 958, 1866, 3612], '2002;': [729, 959, 1589, 2532, 3923, 4493], '51': [730, 960], 'Suppl.': [731, 961], '1:': [732, 962], '190-201Google': [733, 963], 'other': [737, 1478, 4498], 'types': [739, 4501], '(11Clapham': [740, 916], 'D.E.': [741, 917], 'Cell.': [742, 918], '1995;': [743, 919, 1447, 1922, 1978, 3228, 4445, 4458], '80:': [744, 920], '259-268Google': [745, 921], 'However,': [747, 1337, 1621, 4395], 'provided': [751, 3313, 3435, 3987], 'evidence': [752, 1735], 'also': [758, 1248, 1285, 3904], 'play': [759], 'role': [761, 1561], 'Ca2+signaling': [764], '(9Mitchell': [767, 886, 931, 1837, 1935, 2011, 2998, 3183, 4040], '12Emmanouilidou': [790], 'Teschemacher': [792], 'A.G.': [793], 'Pouli': [794, 3251], 'Nicholls': [796], 'L.I.': [797], 'Seward': [798], 'E.P.': [799], 'Curr.': [802, 1503, 3226], '1999;': [804, 1215, 1236, 1271, 1303, 1423, 1487, 1505, 3264], '9:': [805, 1506], '915-918Google': [806], 'Importantly,': [808], 'occupy': [811], 'substantial': [813], 'proportion': [814], 'volume': [818, 2193, 2380, 3345, 3352], '(13Dean': [821], 'P.M.': [822], 'Matthews': [823], 'Theor.': [826], '54:': [829], '309-321Google': [830], 'Scholar,14Rorsman': [831], 'Diabetologia.': [833], '40:': [835, 4224], '487-495Google': [836], 'may': [839, 1451, 1740, 4376, 4410, 4418, 4546], 'contain': [840], 'close': [841, 3073], 'half': [843], 'total': [845, 3350, 3600], 'cellular': [846], 'Ca2+.': [847], 'As': [848], 'such,': [849], 'these': [850, 3691, 3946, 4391], 'organelles': [851], 'potentially': [852], 'provide': [853, 1734], 'huge': [855], 'mobilizable': [858], '(15Hutton': [861], 'J.C.': [862], 'Penn': [863], 'E.J.': [864], 'Peshavaria': [865], 'Biochem.': [867, 1471, 2112, 2720, 2763, 3034, 3084, 3628, 4509], '1983;': [869], '210:': [870], '297-305Google': [871], 'Previous': [873], 'studies': [874, 1479, 3967, 4178], 'involving': [875], 'measurements': [876, 1873], 'intravesicular': [878], '([Ca2+]SV)': [882, 4110], 'immunoelectron': [884], 'microscopy': [885], 'indicated': [909, 3835, 3968], 'ryanodine,': [911], 'inositol': [914], '1,4,5-trisphosphate': [915], 'Scholar),': [922, 1032, 1195, 1335, 1392, 1450, 1592, 1981, 2373, 2725, 3267, 4062, 4256], 'mediate': [924], 'Ca2+release': [925, 4307], '16Ravazzola': [965], 'Halban': [967], 'Orci': [969], 'L.': [970, 1498, 1529, 2356], 'Proc.': [971, 1022, 1185, 1382, 1582, 4486], 'Natl.': [972, 1023, 1186, 1383, 1583, 4487], 'Acad.': [973, 1024, 1187, 1384, 1584, 4488], 'Sci.': [974, 1025, 1188, 1385, 1472, 1585, 2531, 3922, 4489, 4510], 'S.': [976, 1019, 1027, 1052, 1111, 1123, 1141, 1153, 1190, 1321, 1387, 1465, 1581, 1587, 2358, 3033, 4485, 4491, 4503], '93:': [979], '2745-2748Google': [980], 'cDNAs': [982, 3678], 'encoding': [983, 1903], 'three': [984, 2097, 3643], 'isoforms': [986, 3997, 4086, 4392], 'so': [988], 'far': [989], 'been': [990, 1093, 1249, 1286], 'identified': [991, 4434], 'mammals.': [993], 'isoform': [997, 1102], '(RyR': [998], 'I)': [999], 'expressed': [1001, 1101], 'mainly': [1002], 'skeletal': [1004, 2292, 2484, 2824, 3774, 4123, 4192], 'muscle': [1005, 2485, 2743, 2825, 2867, 4124, 4193], '(17Marks': [1006], 'A.R.': [1007], 'Tempst': [1008], 'Hwang': [1010], 'K.S.': [1011], 'Taubman': [1012], 'M.B.': [1013, 2715, 2758], 'Inui': [1014], 'Chadwick': [1016], 'Fleischer': [1018], 'Nadal-Ginard': [1020], '1989;': [1029], '86:': [1030], '8683-8687Google': [1031], 'whereas': [1033, 1393, 1666, 3953, 4155], 'abundant': [1037, 1688, 3862], 'heart': [1040, 1363, 2295, 3789], '(18Nakai': [1041], 'Imagawa': [1043], 'Hakamat': [1045], 'Y.': [1046, 1313, 1319, 1329, 1782, 1784, 3031], 'Shigekawa': [1047], 'Takeshima': [1049], 'Numa': [1051], 'FEBS': [1053, 1269, 1421], 'Lett.': [1054, 1270, 1422], '1990;': [1055, 1788, 2908], '271:': [1056], '169-177Google': [1057], 'III': [1060, 1282, 2134, 2689, 2886, 3685, 3703, 3957], 'variety': [1065, 1547], 'tissues': [1067], 'types,': [1070], 'most': [1071, 1099], 'notably': [1072], 'brain': [1074, 1406, 3705], '(19Ledbetter': [1075], 'M.W.': [1076], 'Preiner': [1077], 'J.K.': [1078], 'Louis': [1079, 4231, 4246], 'C.F.': [1080, 2894, 4232, 4247], 'Mickelson': [1081, 4229], 'J.R.': [1082, 4230], '1994;': [1086, 2370], '269:': [1087, 2371], '31544-31551Google': [1088], 'has': [1092, 1247], 'reported': [1094], 'previously': [1095, 2010, 2705, 2748, 3218, 4474], 'be': [1097, 4288, 4378, 4411, 4477, 4547], 'abundantly': [1100], '(at': [1103], 'mRNA': [1105, 1283, 1351, 3767, 3780], 'level)': [1106], 'wild': [1108], '(20Takasawa': [1110, 1140], 'Akiyama': [1112, 1142], 'Nata': [1114, 1144], 'Kuroki': [1116, 1146], 'Tohgo': [1118, 1148], 'Noguchi': [1120, 1150], 'N.': [1121, 1151, 2360], 'Kobayashi': [1122, 1152], 'Kato': [1124, 1154], 'Katada': [1126, 1156], 'Okamoto': [1128, 1158], '273:': [1134, 1164], '2497-2500Google': [1135, 1165], 'ob/obmouse': [1138], '21Islam': [1167], 'M.S.': [1168, 1365], 'Leibiger': [1169, 1171, 1366, 1368], 'Rossi': [1173, 1370], 'D.': [1174, 1371], 'Sorrentino': [1175, 1372], 'V.': [1176, 1373, 1531], 'Ekstrom': [1177, 1374], 'Westerblad': [1179, 1376], 'Andrade': [1181, 1378], 'F.H.': [1182, 1379], 'Berggren': [1183, 1380], 'P.O.': [1184, 1381], '95:': [1193, 1390], '6145-6150Google': [1194, 1391], 'well': [1197, 1765], 'rat': [1200, 2061, 2290, 2483, 3676, 3752, 3770], '(22Holz': [1202, 1223, 1290], 'G.G.': [1203, 1224, 1291], 'Leech': [1204, 1225, 1292], 'C.A.': [1205, 1226, 1293], 'Heller': [1206, 1227, 1294], 'R.S.': [1207, 1228, 1295], 'Castonguay': [1208, 1229, 1296], 'Habener': [1210, 1231, 1298], 'J.F.': [1211, 1232, 1299], '274:': [1216, 1237, 1304, 3265], '14147-14156Google': [1217, 1238, 1305], 'clonal': [1220], 'βTC3': [1221, 1289], 'Moreover,': [1240], 'presence': [1242, 1714, 3291, 4417], 'INS-1': [1253, 1399], '(23Gamberucci': [1255, 1407], 'Fulceri': [1257, 1409], 'Banhegyi': [1261, 1413], 'Marcolongo': [1263, 1415], 'Watkins': [1265, 1417], 'S.L.': [1266, 1418], 'Benedetti': [1267, 1419], '446:': [1272, 1424], '309-312Google': [1273, 1425], 'Lower': [1275], 'levels': [1276, 1352, 1397, 3768, 3781, 3837], 'detected': [1287, 3415], 'HIT-T15': [1308], '(24Taniguchi': [1310], 'Yamada': [1312], 'Yasuda': [1314], 'Kubota': [1316], 'Ihara': [1318], 'Kagimoto': [1320], 'Kuroe': [1322], 'Watanabe': [1324], 'Inada': [1326], 'Seino': [1328], 'Metab.': [1331], '3:': [1333], '135-138Google': [1334], 'respectively.': [1336], 'physiological': [1339], 'role(s)': [1340], 'RyRs': [1342, 1669, 1729, 3806, 3977, 4203, 4361], 'remains': [1345], 'unclear,': [1346], 'given': [1347, 3342, 4318, 4380], 'inob/ob': [1353], 'mouse': [1354, 1607, 1767, 3737], 'reportedly': [1357], '∼1000-fold': [1358], '(21Islam': [1364], '∼10-fold': [1402], 'lower': [1403, 3764, 3784], 'Receptors': [1427], 'agent': [1439], '(25Lee': [1440, 4438], 'H.C.': [1441, 3298, 4439], 'Aarhus': [1442, 3299, 4440], '270:': [1448, 1923, 4446, 4459], '2152-2157Google': [1449, 4447], 'alternative': [1454, 4398], 'pathway': [1455], 'efflux': [1458, 4281], '(26Patel': [1464, 4502], 'Churchill': [1466, 1482, 4504], 'G.C.': [1467, 1483, 4505], 'Galione': [1468, 1484, 1501, 4506], 'Trends': [1470, 4508], '26:': [1474, 4512], '482-489Google': [1475, 4513], 'Although': [1477, 1567], '(27Cancela': [1480], 'Nature.': [1486], '398:': [1488], '74-76Google': [1489], '28Bak': [1491], 'White': [1493, 3222, 3359], 'Timar': [1495], 'Missiaen': [1497], 'Genazzani': [1499], 'A.A.': [1500], '751-754Google': [1507], '29Berg': [1509], 'Potter': [1511], 'B.V.': [1512], 'Mayr': [1513], 'Guse': [1515], 'A.H.': [1516], '2000;': [1520, 1617, 1867, 2114, 3613], '150:': [1521], '581-588Google': [1522], '30Mojzisova': [1524], 'Krizanova': [1526], 'O.': [1527, 3029], 'Zacikova': [1528], 'Kominkova': [1530], 'Ondrias': [1532], 'Pfluegers': [1534], 'Arch.': [1535], '441:': [1537], '674-677Google': [1538], 'NAADP-induced': [1542, 1593], 'mammalian': [1549, 2678, 2685, 4499], 'lines,': [1553], 'few': [1554], 'data': [1555], 'currently': [1557], 'available': [1558], 'regarding': [1559], 'β-cell.': [1566], 'functional': [1568, 4021, 4412], 'NAADP-sensitive': [1569], 'revealed': [1574, 2914, 3731, 3762], 'human': [1576, 4480], '(31Johnson': [1578, 4482], 'J.D.': [1579, 4483], 'Misler': [1580, 4484], '99:': [1590, 4494], '14566-14571Google': [1591, 4495], 'was': [1596, 1685, 2055, 2083, 2296, 2301, 2386, 2466, 2514, 2549, 2555, 2657, 2729, 2809, 2913, 3022, 3330, 3405, 3414, 3452, 3574, 3619, 3648, 3687, 3707, 3720, 3815, 3859, 3889, 3903, 3942, 3962, 3978, 4166, 4181, 4316, 4530], 'observed': [1598], 'dispersed': [1600], 'normal': [1604], 'ob/ob': [1606], '(32Tengholm': [1609], 'Hellman': [1611], 'Gylfe': [1613], 'Calcium.': [1616], '27:': [1618], '43-51Google': [1619], 'report,': [1625], 'neither': [1626, 4156], 'agonists': [1629], 'caffeine': [1630], 'nor': [1633, 4161], 'ADP-ribose': [1635], '(cADPr)': [1636], 'induced': [1637], 'release.': [1639, 1732], 'study,': [1643], 'two': [1652, 3996], 'isoforms,': [1654, 3834], 'display': [1661], 'distinct': [1662], 'localizations.': [1664], 'Thus,': [1665], 'at': [1672, 1982, 2190, 2377, 2574, 2798, 2995, 3043, 3063, 3102, 3407, 3416, 3428, 3440, 3459, 3480, 3569, 3595, 3641, 4468], 'approximately': [1673], 'equal': [1674], 'density': [1675], 'vesicle/mitochondrial': [1678, 3898], 'fraction,': [1679, 3866], 'microsomes,': [1682, 2744], 'considerably': [1686], 'more': [1687, 3861, 4332], 'membranes.': [1691], 'Surprisingly,': [1692], 'selective': [1695, 3935], 'I,': [1699, 4263], 'increased': [1700, 4136], 'steady-state': [1701, 4099], '[Ca2+]': [1703, 1872, 3618], 'ER,': [1711, 1754, 2643], 'suggesting': [1712, 4257], 'further': [1719, 3592], 'activator': [1720], 'channel': [1722, 4296, 4409], 'capable': [1723], 'amplifying': [1725], 'effects': [1727, 4428, 4543], 'serve': [1741], 'this': [1742, 3140, 3429, 4169, 4295, 4351, 4472], 'role,': [1743, 4302], 'thus': [1746], 'demonstrate': [1747, 3884], 'NAADP-responsive': [1757], 'β-cells.': [1761, 4272, 4313], 'cells,': [1763], 'differentiated': [1766], 'insulinoma': [1768], 'line': [1770], '(33Miyazaki': [1771], 'Araki': [1773], 'Yamato': [1775], 'Ikegami': [1777], 'Asano': [1779], 'Shibasaki': [1781], 'Oka': [1783], 'Yamamura': [1785], 'Endocrinology.': [1787], '127:': [1789], '126-132Google': [1790], '(passages': [1792], '20–30),': [1793], 'grown': [1795, 1889], "Dulbecco's": [1797], 'modified': [1798, 2961], "Eagle's": [1799], 'medium': [1800, 3547, 3573], '(Invitrogen)': [1801], 'containing': [1802, 1834, 2606, 3550], '25': [1803, 2156, 2319, 2417], 'mm': [1804, 1818, 2157, 2163, 2320, 2326, 2600, 2967, 2970, 2975, 2978, 2981, 2990, 3051, 3113, 3116, 3121, 3124, 3127, 3130, 3134, 3167, 3212, 3521, 3552, 3588], '2': [1807, 2205, 2397, 2432, 2983, 3064, 3123, 3129, 3293, 3331, 4153, 4159, 4164], 'mmpyruvate,': [1808], 'supplemented': [1810, 2497, 2987, 3048, 3510, 3562, 3585], 'with': [1811, 1874, 1897, 2085, 2473, 2498, 2541, 2558, 2697, 2738, 2796, 2823, 2865, 2915, 2948, 2988, 3024, 3049, 3057, 3095, 3268, 3511, 3563, 3583, 3586, 3734, 3823, 3867, 3906, 4176, 4323], '15%': [1812], '(v/v)': [1813, 2500, 2608, 2778, 2848], 'fetal': [1814], 'bovine': [1815], 'serum,': [1816], '20': [1817, 2452, 3096, 3133], 'glutamine,': [1819], '100': [1820, 1823, 4515], 'units/ml': [1821], 'penicillin,': [1822], 'μg/ml': [1824], 'streptomycin,': [1825], '50': [1827, 2195, 2382], 'μm': [1828, 2181, 2344, 2352, 3026, 3097, 3164, 3294, 3513, 3516], 'β-mercaptoethanol,': [1829], 'humidified': [1832], 'atmosphere': [1833], '5%': [1835, 2607, 2777, 2847], 'CO2': [1836], '34Ainscow': [1860], 'Zhao': [1862, 3608], '49:': [1868, 3614], '1149-1155Google': [1869, 3615], 'For': [1871, 2769], 'recombinant': [1875], 'aequorins': [1876], '(see': [1877, 3548, 3698, 3939], 'below),': [1878], 'seeded': [1881, 3209], 'onto': [1882, 2853, 3210], '13-mm': [1883], 'diameter': [1884], 'poly-l-lysine-coated': [1885, 3213], 'glass': [1886], 'coverslips': [1887, 3214], '50–80%': [1891], 'confluency.': [1892], 'Cells': [1893, 2941, 3526], 'then': [1895, 2208, 2228, 2387, 2400, 2420, 2435, 2455, 2556, 2572, 3528, 3558, 3581], 'infected': [1896, 2540], 'Cyt.Aq,': [1898], 'VAMP.Aq,': [1899], 'ER.Aq': [1901], 'adenoviruses': [1902], 'untargeted': [1904], '(Cyt.Aq)': [1906], '(35Brini': [1907], 'Marsault': [1909, 1966], 'Alvarez': [1913, 1968], '9896-9903Google': [1924], '(VAMP.Aq)': [1934], '(ER.Aq)': [1961], '(36Montero': [1962], 'Sitia': [1970], '14:': [1979], '5467-5475Google': [1980], 'multiplicity': [1984], 'infection': [1986], '30': [1988, 3567, 3587, 3593], 'infectious': [1989], 'units': [1990], 'per': [1991], 'cell.': [1992], 'Measurements': [1993], 'bioluminescence': [1996], 'performed': [1998, 2084, 2237, 2302, 2388, 3649, 3905], 'using': [1999, 2063, 2074, 2271, 2617, 2932, 3393, 3422, 3621, 3650, 3693], 'purpose-built': [2001], 'photomultiplier': [2002, 3077], 'system': [2003, 2938, 3383], '48': [2004], 'h': [2005, 3042, 3370, 3556], 'after': [2006, 3371, 3485], 'infection,': [2007], 'described': [2009, 2704, 2747, 3219], '37Rutter': [2034], '268:': [2050], '22385-22390Google': [2051], 'Total': [2053, 2287], 'RNA': [2054, 2288], 'extracted': [2056, 2487], 'tissue': [2062], 'TRI': [2064], 'ReagentTM': [2065], '(Sigma)': [2066], 'according': [2067], "manufacturer's": [2070], 'instructions': [2071], 'reverse-transcribed': [2073], 'Moloney': [2075], 'murine': [2076], 'leukemia': [2077], 'virus-reverse': [2078], 'transcriptase': [2079], '(Promega).': [2080], 'PCR': [2081, 2140, 2254, 2300, 2385, 3659, 3718, 3761], 'amplification': [2082], 'primers': [2086, 2354], 'designed': [2087], 'amplify': [2089], 'isoform-specific': [2091, 3657], 'region': [2092], 'each': [2094, 2469, 3714, 4015, 4071, 4389], 'subtypes': [2099], '(38Fitzsimmons': [2100], 'Gukovsky': [2102], 'McRoberts': [2104], 'J.A.': [2105, 2892], 'Rodriguez': [2106], 'Lai': [2108, 2718, 2761], 'F.A.': [2109, 2719, 2762], 'Pandol': [2110], 'S.J.': [2111, 2898], '351:': [2115], '265-271Google': [2116], 'follows:': [2119, 2201, 2390], '(forward,': [2122, 2128, 2135], '5′-GAAGGTTCTGGACAAACACGGG-3′;': [2123], 'reverse,': [2124, 2130, 2137], '5′-TCGCTCTTGTTGTAGAATTTGCGG-3′);': [2125], '5′-GAATCAGTGAGTTACTGGGCATGG-3′;': [2129], '5′-CTGGTCTCTGAGTTCTCCAAAAGC-3′);': [2131], '5′-CCTTCGCTATCAACTTCATCCTGC-3′;': [2136], '5′-TCTTCTACTGGGCTAAAGTCAAGG-3′).': [2138], 'mix': [2141], 'consisted': [2142], '5': [2144, 2174, 2307, 2337, 2631, 3025], 'μl': [2145, 2154, 2160, 2166, 2175, 2308, 2317, 2323, 2329, 2338], '10×': [2147, 2310], 'Buffer': [2148, 2311], '3': [2149, 2312, 2977, 3551, 3564, 4537], '(Roche': [2150, 2171, 2313, 2334, 2561, 2939], 'Molecular': [2151, 2172, 2314, 2335, 2562], 'Biochemicals),': [2152, 2173, 2315, 2336], '6': [2153, 2316], 'MgCl2,': [2158, 2321], '1': [2159, 2222, 2322, 2414, 2449, 2639, 2989, 3050, 3100, 3118, 3126, 3438, 3512, 3520, 3851, 3880, 3949, 3959, 4344], '10': [2162, 2232, 2325, 2424, 2459, 2578, 2624, 2980, 2993, 3115, 3166, 3515, 3524], 'dNTPs,': [2164, 2327], '0.25': [2165, 2328], 'Taq': [2168, 2331], 'DNA': [2169, 2332], 'polymerase': [2170, 2333], 'reverse': [2177, 2242, 2340], 'transcriptase-PCR': [2178, 2341], 'cDNA,': [2179, 2342, 3776], '0.4': [2180, 2184, 2343], 'forward': [2182], 'primer,': [2183], 'μmreverse': [2185], 'primers,': [2186, 2350, 2393, 2428, 3658], 'distilled': [2188, 2375], 'H2O,': [2189], 'final': [2192, 2379, 3336], 'μl.': [2196, 2383], 'Amplification': [2197, 2461], 'conditions': [2198], '94': [2202, 2209, 2394, 2401, 2429, 2436], '°C': [2203, 2210, 2215, 2220, 2230, 2395, 2402, 2407, 2412, 2422, 2430, 2437, 2442, 2447, 2457, 2576, 2997, 3045, 3104], 'min': [2206, 2223, 2398, 2433, 2579, 2994, 3101, 3568, 3594], '45': [2212, 2217, 2404, 2409, 2439, 2444], 's,': [2213, 2218, 2405, 2410, 2440, 2445], '55.5': [2214], '72': [2219, 2229, 2411, 2421, 2446, 2456], '32': [2225], 'cycles': [2226, 2418, 2453, 2475], 'min.': [2233, 2460, 3525], 'Negative': [2234], 'controls': [2235], 'omission': [2239], 'transcription': [2243], 'step': [2244], 'exclusion': [2247], 'template': [2250], 'PCR.': [2253], 'products': [2255, 3660, 3719], 'separated': [2257, 2774], 'migration': [2259], '2%': [2262], '(w/v)': [2263, 2504, 2509], 'agarose': [2264], 'gel.': [2265], 'Products': [2266], 'excised': [2268], 'purified': [2270], 'QIAQuickTM': [2273], 'gel': [2274, 2780], 'extraction': [2275], 'kit': [2276], '(Qiagen)': [2277], 'subjected': [2279], 'restriction': [2281, 3724], 'digest': [2282], 'analysis': [2283, 2737, 3647, 3725], 'automated': [2285], 'sequencing.': [2286], 'islets,': [2291], 'muscle,': [2293], 'reverse-transcribed,': [2297], 'semi-quantitative': [2299], 'following': [2305, 2619, 2814, 2858], 'mix:': [2306], '0.1': [2351], 'β-actin': [2353], '(39Miquerol': [2355], 'Lopez': [2357], 'Cartier': [2359], 'Tulliez': [2361], 'Raymondjean': [2363], 'Kahn': [2365, 3238], '8944-8951Google': [2372], 'H2O': [2376], 'Semi-quantitative': [2384, 3760], '55': [2406], 'min,': [2415, 2450, 2625, 2632], 'min;': [2425], '58': [2441], 'linear': [2464], 'phase': [2465], 'confirmed': [2467, 2730, 3721], 'case': [2470], 'trials': [2472], '12–30': [2474], '(data': [2476, 3679, 3791], 'shown).': [2478, 3681, 3793], 'homogenized': [2482], 'into': [2488], 'radioimmunoprecipitation': [2489], 'assay': [2490, 2734], '(RIPA)': [2491], 'buffer,': [2492, 3283], 'consisting': [2493], 'phosphate-buffered': [2495], 'saline': [2496], '1%': [2499], 'Nonidet': [2501], 'P-40,': [2502], '0.5%': [2503], 'sodium': [2505, 3131], 'deoxycholate,': [2506], '0.1%': [2508], 'SDS.': [2510], 'Secretory': [2511], 'obtained': [2515], 'immunoadsorption': [2517], 'phogrin.EGFP-containing': [2519], '(40Varadi': [2521, 3912], 'Allan': [2525, 3916], 'V.J.': [2526, 3917], '115:': [2533, 3924], '4177-4189Google': [2534, 3925], 'brief,': [2537], 'phogrin.EGFP': [2542], 'homogenized,': [2544], 'nuclear': [2547, 2626], 'fraction': [2548, 3878, 3899, 4342], 'removed': [2550, 3575], 'centrifugation.': [2552], 'Pre-cleared': [2553], 'homogenate': [2554], 'incubated': [2557, 2573, 3543, 3559], 'anti-GFP': [2559], 'antibody': [2560, 2727, 2797, 2804, 2869, 3938], 'Biochemicals)': [2563], 'bound': [2564], 'A-Sepharose.': [2567], 'Immunoadsorbed': [2568], 'washed': [2571], '99': [2575], 'SDS-PAGE': [2581, 2845], 'loading': [2582], 'buffer': [2583, 2598, 2964, 3110, 3141], 'dissociate': [2585], 'proteins.': [2587], 'To': [2588, 3883, 4003, 4539], 'generate': [2589], 'fractions,': [2592], 'harvested': [2595], 'Tris-saline': [2597], '(10': [2599, 2950, 2953, 2958, 4076], 'Tris-HCl,': [2601], '0.14': [2602], 'mNaCl,': [2603], 'pH': [2604, 2985, 3136, 3284], '7.4)': [2605, 2986], 'Tween': [2609], '40.': [2610], 'Fractions': [2611], 'collected': [2613], 'differential': [2615], 'centrifugation': [2616], 'spins:': [2620], '200': [2621], '×g': [2622, 2637], 'fraction;': [2627, 2635, 2645], '15,000': [2628], '×': [2629, 2649], 'gfor': [2630], 'mitochondrial/secretory': [2633], '100,000': [2636, 2648], 'h,': [2640], 'membrane,': [2642, 4000], 'supernatant': [2646], 'g': [2650], 'spin,': [2651], 'fraction.': [2653], 'Rabbit': [2654], 'polyclonal': [2655], 'antiserum': [2656], 'raised': [2658, 4097], 'I-specific': [2662], 'sequence': [2663], '15': [2665], 'amino': [2666], 'acids': [2667], '(residues': [2668], '830–845;': [2669], 'RREGPRGPHLVGPSRC)': [2670], '100%': [2673, 3732], 'conserved': [2674], 'all': [2676, 3153, 4084], 'known': [2677], 'RyRI': [2679], 'sequences': [2680], 'absent': [2682], 'sequences.': [2690], 'Rabbits': [2691], '(New': [2692], 'Zealand': [2693], 'White)': [2694], 'immunized': [2696], 'keyhole': [2699], 'limpet': [2700], 'hemocyanin-conjugated': [2701], 'peptide': [2702], '(41Tunwell': [2706, 2749], 'R.E.': [2707, 2750], 'Wickenden': [2708, 2751], 'Bertrand': [2710, 2753], 'B.M.': [2711, 2754], 'Shevchenko': [2712, 2755], 'V.I.': [2713, 2756], 'Walsh': [2714, 2757], 'Allen': [2716, 2759], 'P.D.': [2717, 2760], '318:': [2723, 2766], '477-487Google': [2724, 2767], 'specificity': [2728], 'enzyme-linked': [2732], 'immunosorbent': [2733], 'immunoblot': [2736, 2770], 'brain,': [2739], 'skeletal,': [2740], 'cardiac': [2742, 4200], 'prepared': [2745, 2810], 'analysis,': [2771], 'microsomes': [2772], 'polyacrylamide': [2779, 2849], '(30': [2781], 'μg': [2782], 'protein/lane),': [2784], 'proteins': [2786], 'electrophoretically': [2788], 'transferred': [2789, 2852], 'polyvinylidene': [2791, 2830], 'difluoride': [2792, 2831], 'before': [2794, 3483], 'probing': [2795], 'dilution': [2800], '1:1000.': [2802], 'Affinity-purified': [2803], '(anti-RyR': [2805], 'I;': [2806], 'number': [2807, 2877, 2889, 4357], '2142)': [2808], 'elution': [2813], 'incubation': [2815, 2947, 3506], 'crude': [2818, 3819, 3876, 3896, 4339], 'antisera': [2821], 'immobilized': [2828], 'strips': [2833], 'A-agarose': [2837], 'columns': [2838], '(Sigma).': [2839], 'Protein': [2840], 'samples': [2841], 'resolved': [2843], 'gels': [2850], 'Immobilon-P': [2854], 'transfer': [2855], '(Millipore)': [2857], 'standard': [2860], 'protocol.': [2861], 'Membranes': [2862], 'probed': [2864], 'anti-skeletal': [2866], '(1:2500;': [2870], 'Upstate': [2871], 'Biotechnology,': [2872], 'Inc.),': [2873], 'anti-RyR': [2874, 2879, 2885, 3930, 3936], '(1:500;': [2876, 2888], '2142),': [2878], '(1:200;': [2881], 'Affinity': [2882], 'BioReagents),': [2883], 'antibodies': [2887, 4383], '110E)': [2890], '(42Airey': [2891], 'Beck': [2893], 'Murakami': [2895], 'Tanksley': [2897], 'Deerinck': [2899], 'Ellisman': [2901], 'M.H.': [2902], 'Sutko': [2903], 'J.L.': [2904], '265:': [2909], '14187-14194Google': [2910], 'Immunostaining': [2912], 'horseradish': [2916], 'peroxidase-conjugated': [2917], 'anti-rabbit': [2918], 'IgG': [2919, 2924, 2929], '(Sigma;': [2920, 2925], '1:100': [2921], '000),': [2922], 'anti-mouse': [2923], '1:10,000),': [2926], 'anti-sheep': [2928], '(Dako;': [2930], '1:4000)': [2931], 'chemiluminescence': [2935], '(ECL)': [2936], 'detection': [2937], 'Diagnostics).': [2940], 'depleted': [2943, 3495], 'ionomycin': [2949], 'μm),': [2951, 2954], 'monensin': [2952], 'cyclopiazonic': [2956, 3517], 'μm)': [2959, 4077], 'Krebs-Ringer': [2962], 'bicarbonate': [2963], '(KRB:': [2965], '140': [2966, 3112], 'NaCl,': [2968, 3117], '3.5': [2969], 'KCl,': [2971, 3114], '0.5': [2972, 2974], 'mmNaH2PO4,': [2973], 'MgSO4,': [2976, 3125], 'glucose,': [2979, 3122], 'Hepes,': [2982, 3135], 'mmNaHCO3,': [2984], 'EGTA,': [2991], '4': [2996, 3044], 'Aequorin': [3021], 'reconstituted': [3023], 'coelenterazine': [3027], 'n(43Shimomura': [3028], 'Kishi': [3030], 'Inouye': [3032], '296:': [3037], '549-551Google': [3038], '1–2': [3041], 'KRB': [3047, 3058, 3504, 3509, 3532, 3561, 3584], 'EGTA.': [3052], 'Intact': [3053], 'perifused': [3056, 3107], 'plus': [3059], 'additions': [3060], 'stated': [3062, 3144], 'ml·min−1': [3065], 'thermostatted': [3068], 'chamber': [3069], '(37': [3070], '°C)': [3071], 'proximity': [3074], 'tube': [3078], '(ThornEMI)': [3079], '(44Cobbold': [3080], 'P.H.': [3081], 'Rink': [3082], '1987;': [3086], '248:': [3087], '313-328Google': [3088], 'Where': [3090, 3489], 'indicated,': [3091, 3490], 'digitonin': [3098], '37': [3103, 3570, 3596], 'subsequently': [3106], '(IB:': [3111], 'mmKH2PO4,': [3119], '5.5': [3120], 'ATP,': [3128], 'succinate,': [3132], '7.05).': [3137], 'Additions': [3138], 'figure': [3147], 'legends.': [3148], 'At': [3149], 'end': [3151], 'experiments': [3154], 'lysed': [3157], 'hypotonic': [3160], 'Ca2+-rich': [3161], 'solution': [3162], '(100': [3163], 'digitonin,': [3165], 'H20)': [3170], 'discharge': [3172], 'remaining': [3174], 'pool': [3176], 'calibration': [3178], 'signal': [3182], '24': [3211], 'microinjected,': [3216], '(45Rutter': [3220], 'M.R.': [3223, 3360], 'Tavare': [3224, 3361], '5:': [3229, 3366], '890-899Google': [3230], '46Kennedy': [3232], 'H.J.': [3233, 3250, 3356], 'Viollet': [3234], 'Rafiq': [3236], '272:': [3246, 3309, 4237], '20636-20640Google': [3247], '47Kennedy': [3249], 'Jouaville': [3255], 'L.S.': [3256, 4217], '13281-13291Google': [3266], 'Oregon': [3269], 'Green': [3270], '488': [3271, 3408], '1,2-bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic': [3272], 'acid-1': [3273], 'dextran': [3274], '(Molecular': [3275], 'Probes,': [3276], 'Eugene,': [3277], 'OR;': [3278], '2.5': [3279], 'mg·ml−1)': [3280], 'Tris-HCl': [3282], '8.0,': [3285], 'absence': [3288], '(control)': [3289], '(48Lee': [3297], 'Gee': [3301], 'K.R.': [3302], 'Kestner': [3303], '4172-4178Google': [3310], '(kindly': [3312], 'Dr.': [3315], 'Luigia': [3316], 'Santella,': [3317], 'University': [3318], 'Naples).': [3320], 'microinjection': [3328], 'pipette': [3329], 'μm,': [3332], 'resulting': [3333], '50–150': [3340], 'nm,': [3341], 'injection': [3344], '2.5–7.5%': [3347], '(49Rutter': [3353], 'Kennedy': [3355], 'Wood': [3357], 'C.D.': [3358], 'R285-R290Google': [3367], '2–4': [3369], 'microinjection,': [3372], 'imaged': [3375], 'Leica': [3378, 3387], 'TCS-SP2': [3379], 'laser-scanning': [3380], 'confocal': [3381, 3475, 3534], 'illumination': [3382], 'attached': [3384], 'DM': [3388], 'IRBE': [3389], 'inverted': [3390], 'epifluorescence': [3391], 'microscope,': [3392], '63×': [3395], 'PL': [3396], 'Apo': [3397], '1.4': [3398], 'numerical': [3399], 'aperture': [3400], 'oil': [3401], 'immersion': [3402], 'objective.': [3403], 'Fluorescence': [3404], 'excited': [3406], 'nm': [3409, 3421, 3446, 4516], '(argon': [3410], 'laser),': [3411], 'fluorescence': [3413], 'wavelengths': [3417, 3441], 'longer': [3418], '515': [3420], 'long': [3424], 'pass': [3425], 'cut-off': [3426], 'filter': [3427], 'wavelength.': [3430], 'A': [3431, 4117], 'second': [3432], 'laser': [3433], '(CoherentTM)': [3434], 'light': [3436], 's': [3439], '351': [3443], '364': [3445], '(via': [3447], 'objective': [3449], 'lens)': [3450], 'used': [3453, 4019, 4386], 'selected': [3460], 'regions': [3461], 'interest': [3463], 'within': [3464], '(corresponding': [3467], '∼1%': [3469], 'surface': [3472], 'slice).': [3476], 'Images': [3477], 'acquired': [3479], '5-s': [3481], 'intervals': [3482], 'UV': [3487], 'pulse.': [3488], 'ER/Golgi': [3491], 'washing': [3499], 'Ca2+-free': [3503, 3508, 3531], 'thapsigargin,': [3514], 'acid,': [3518], 'EGTA': [3522], 'maintained': [3529], 'during': [3533], 'imaging': [3535], 'photorelease': [3537], 'NAADP.': [3539], 'full': [3545], 'growth': [3546], 'above)': [3549], '16': [3555], 'mmglucose': [3565], '°C.': [3571, 3597], 'retained,': [3577], 'stimulated': [3582], 'Released': [3598], 'measured': [3603], 'radioimmunoassay': [3605], '(34Ainscow': [3606], 'Free': [3617], 'calculated': [3620], 'METLIG': [3622], 'software': [3623], '(50Rutter': [3624], 'Denton': [3626], 'R.M.': [3627], '1988;': [3630], '252:': [3631], '181-189Google': [3632], 'Data': [3634], 'means': [3637], 'S.E.': [3639], 'least': [3642], 'separate': [3644], 'experiments.': [3645], 'Statistical': [3646], 'paired': [3652], "Student's": [3653], 't': [3654], 'test.': [3655], 'Using': [3656], 'corresponding': [3661, 3736], 'cDNA': [3668, 3686, 3706, 3790], 'readily': [3670], 'amplified': [3671, 3689], 'MIN6-,': [3673], 'INS1-,': [3674], 'islet-derived': [3677, 3771], 'By': [3682, 3854], 'contrast,': [3683, 3855, 4121], 'sources': [3692], 'chosen': [3695], 'primer': [3696], 'pair': [3697], '"Experimental': [3699, 3940], 'Procedures"),': [3700, 3941], 'although': [3701, 4278], 'amplified,': [3708], 'expected.': [3710], 'identity': [3712, 3733], 'generated': [3717], 'both': [3723, 3842, 3929, 4105], 'automatic': [3728], 'sequencing,': [3729], 'which': [3730, 3828], '(GenBankTM': [3738, 3753], 'accession': [3739, 3754], 'numbers': [3740, 3755], 'X83932': [3741], 'AF295105': [3743], 'respectively)': [3750], 'AF130879': [3756], 'U95157)': [3758], 'cDNAs.': [3759], '∼5-fold': [3763], 'muscle-derived': [3775], '∼8-fold': [3783], 'order': [3795], 'confirm': [3797], 'presence,': [3799], 'identify': [3801], 'localization,': [3804], 'immunoblotting': [3813, 3902], '(Western)': [3814], 'performed.': [3816], 'Probing': [3817], 'fractions': [3822, 3849, 4321], 'subtype-specific': [3825], 'antibody,': [3827], 'recognizes': [3829], '(and': [3832], 'III)': [3833], 'mitochondrial/dense': [3843], 'microsomal': [3848], '(Fig.': [3850, 3879, 3948, 3958, 4158, 4163, 4343, 4393, 4536], 'A,upper': [3852, 4345], 'panel).': [3853, 3882, 4346], 'much': [3860, 4367], 'only': [3868], 'weak': [3869], 'staining': [3870], 'vesicle/mitochondria': [3877, 4341], 'A,lower': [3881], 'examined': [3900, 4464], 'above,': [3901], 'immunopurified': [3907], 'Immunoreactivity': [3927], 'toward': [3928], 'I/III,': [3931], 'clearly': [3943], 'evident': [3944], 'B,': [3950], 'upper': [3951], 'panels),': [3952], 'reactivity': [3954], 'B,lower': [3960], 'panel)': [3961], 'undetectable.': [3963], 'above': [3965, 4274], 'relative': [3971, 3992, 4006], 'abundance': [3972, 3993], 'I/type': [3975], 'higher': [3979], 'information': [3989], 'considered': [4001], 'alone.': [4002], 'determine': [4004, 4540], 'importance': [4007], 'organelle,': [4016], 'therefore': [4018, 4463], 'approach': [4022], 'living': [4024], 'Recombinant': [4027], 'specifically': [4030], 'organelle': [4033], 'addition': [4036], 'appropriate': [4038], 'presequences': [4039], 'utilized': [4064], 'monitor': [4066], 'compartment.': [4072], 'Concentrations': [4073], 'expected': [4078], 'lead': [4080], 'closure': [4082], '(51Meissner': [4087], '6300-6306Google': [4094], 'matrix': [4109], 'lumen': [4114], '([Ca2+]ER)': [4115], '(Fig.2,': [4116], 'B).': [4119, 4538], 'relaxant': [4125], '(52Van': [4127, 4204], 'Winkle': [4128, 4205], 'W.B.': [4129, 4206], '1976;': [4131, 4208], '193:': [4132, 4209], '1130-1131Google': [4133, 4210], 'significantly': [4135], '[Ca2+]SV': [4137, 4430, 4526], 'μm;': [4146], 'n': [4147], '4,p': [4149], '0.01;': [4151], 'Fig.': [4152], 'C),': [4154], '[Ca2+]ER': [4157, 4535], 'D)': [4160], '[Ca2+]c': [4162], 'E)': [4165], 'affected': [4167], 'agent.': [4170], 'These': [4171], 'findings': [4172], 'agreement': [4175], 'previous': [4177], 'where': [4179], 'shown': [4182, 4475], 'bind': [4184], 'directly': [4185], 'inhibit': [4188], 'pig': [4189], 'rabbit': [4191], '(types': [4194], 'III),': [4197], '(type': [4201], 'II),': [4202], '53Paul-Pletzer': [4212], 'Palnitkar': [4214], 'S.S.': [4215], 'Jimenez': [4216], 'Morimoto': [4218], 'Parness': [4220], 'Biochemistry.': [4222], '531-542Google': [4225], '54Fruen': [4227], 'B.R.': [4228, 4249], '26965-26971Google': [4238], '55Zhao': [4240], 'F.': [4241], 'Li': [4242], 'Chen': [4244], 'S.R.': [4245], 'Fruen': [4248], '276:': [4254], '13810-13816Google': [4255], 'inhibits': [4260], 'results': [4275], 'suggest': [4276], 'ryanodine-sensitive': [4279], 'likely': [4286], 'mediated': [4289, 4548], 'principally': [4290], 'RyRs,': [4294], 'subtype': [4297], 'apparently': [4298, 4326], 'plays': [4299], 'minor': [4301], 'if': [4303], 'any,': [4304], 'mediating': [4306], 'This': [4314], 'unexpected': [4317], 'enriched': [4322], 'contained': [4327], 'same': [4329], 'amount': [4330], 'One': [4347], 'simple': [4348], 'explanation': [4349], 'observation': [4352], 'absolute': [4356], 'very': [4366], 'greater': [4368], 'receptors,': [4372], 'difference': [4374], 'apparent': [4379], 'different': [4382], 'dilutions': [4385], 'quantitate': [4388], '1).': [4394], 'explanation,': [4399], 'next': [4401], 'explored': [4402], 'possibility': [4404], 'another': [4406], 'whose': [4416], 'stimulate': [4419], 'activity': [4421], 'neighboring': [4423], 'channels.': [4426], 'molecule': [4436], '56Chini': [4449], 'E.N.': [4450], 'Beers': [4451], 'K.W.': [4452], 'Dousa': [4453], 'T.P.': [4454], '3216-3223Google': [4460], 'compound': [4473], 'optimal': [4478], 'caused': [4518], 'small': [4520], 'highly': [4522], 'decrease': [4524], '(Fig.3': [4527], 'A)': [4528], 'completely': [4531], 'without': [4532], 'whether': [4541], 'identical': [4552]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2047510863', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 11}, {'year': 2014, 'cited_by_count': 10}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 7}], 'updated_date': '2024-12-24T15:04:22.994276', 'created_date': '2016-06-24'}
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