Publication Information

{'id': 'https://openalex.org/W2047094448', 'doi': 'https://doi.org/10.1097/ajp.0000000000000236', 'title': 'Pharmacogenetic Testing for Analgesic Adverse Effects', 'display_name': 'Pharmacogenetic Testing for Analgesic Adverse Effects', 'publication_year': 2015, 'publication_date': '2015-03-24', 'ids': {'openalex': 'https://openalex.org/W2047094448', 'doi': 'https://doi.org/10.1097/ajp.0000000000000236', 'mag': '2047094448', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/25803758'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1097/ajp.0000000000000236', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S102460418', 'display_name': 'Clinical Journal of Pain', 'issn_l': '0749-8047', 'issn': ['0749-8047', '1536-5409'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5090675801', 'display_name': 'Renee C.B. Manworren', 'orcid': 'https://orcid.org/0000-0003-3626-0990'}, 'institutions': [{'id': 'https://openalex.org/I140172145', 'display_name': 'University of Connecticut', 'ror': 'https://ror.org/02der9h97', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I140172145']}, {'id': 'https://openalex.org/I4210101648', 'display_name': "Connecticut Children's Medical Center", 'ror': 'https://ror.org/01a1jjn24', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210101648']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Renee C.B. Manworren', 'raw_affiliation_strings': ['Center for the Advancement in Managing Pain, University of Connecticut School of Nursing Storrs', 'Department of Pediatrics, University of Connecticut School of Medicine, Farmington', "Division of Pain and Palliative Medicine, Connecticut Children's Medical Center, Hartford, CT"], 'affiliations': [{'raw_affiliation_string': 'Center for the Advancement in Managing Pain, University of Connecticut School of Nursing Storrs', 'institution_ids': ['https://openalex.org/I140172145']}, {'raw_affiliation_string': "Division of Pain and Palliative Medicine, Connecticut Children's Medical Center, Hartford, CT", 'institution_ids': ['https://openalex.org/I4210101648']}, {'raw_affiliation_string': 'Department of Pediatrics, University of Connecticut School of Medicine, Farmington', 'institution_ids': ['https://openalex.org/I140172145']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086727705', 'display_name': 'Lauren Jeffries', 'orcid': 'https://orcid.org/0000-0002-6419-0515'}, 'institutions': [{'id': 'https://openalex.org/I140172145', 'display_name': 'University of Connecticut', 'ror': 'https://ror.org/02der9h97', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I140172145']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Lauren Jeffries', 'raw_affiliation_strings': ['Department of Pediatrics, University of Connecticut School of Medicine, Farmington'], 'affiliations': [{'raw_affiliation_string': 'Department of Pediatrics, University of Connecticut School of Medicine, Farmington', 'institution_ids': ['https://openalex.org/I140172145']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065969812', 'display_name': 'Ashley Pantaleao', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210101648', 'display_name': "Connecticut Children's Medical Center", 'ror': 'https://ror.org/01a1jjn24', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210101648']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Ashley Pantaleao', 'raw_affiliation_strings': ["Division of Pain and Palliative Medicine, Connecticut Children's Medical Center, Hartford, CT"], 'affiliations': [{'raw_affiliation_string': "Division of Pain and Palliative Medicine, Connecticut Children's Medical Center, Hartford, CT", 'institution_ids': ['https://openalex.org/I4210101648']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110408988', 'display_name': 'Richard L. Seip', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1302163369', 'display_name': 'Hartford Hospital', 'ror': 'https://ror.org/00gt5xe03', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1302163369']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Richard Seip', 'raw_affiliation_strings': ['Genetics Research Center, Hartford Hospital, Hartford'], 'affiliations': [{'raw_affiliation_string': 'Genetics Research Center, Hartford Hospital, Hartford', 'institution_ids': ['https://openalex.org/I1302163369']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065563083', 'display_name': 'William T. Zempsky', 'orcid': 'https://orcid.org/0000-0001-7162-0002'}, 'institutions': [{'id': 'https://openalex.org/I140172145', 'display_name': 'University of Connecticut', 'ror': 'https://ror.org/02der9h97', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I140172145']}, {'id': 'https://openalex.org/I4210101648', 'display_name': "Connecticut Children's Medical Center", 'ror': 'https://ror.org/01a1jjn24', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210101648']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'William T. Zempsky', 'raw_affiliation_strings': ['Center for the Advancement in Managing Pain, University of Connecticut School of Nursing Storrs', 'Department of Pediatrics, University of Connecticut School of Medicine, Farmington', "Division of Pain and Palliative Medicine, Connecticut Children's Medical Center, Hartford, CT"], 'affiliations': [{'raw_affiliation_string': 'Center for the Advancement in Managing Pain, University of Connecticut School of Nursing Storrs', 'institution_ids': ['https://openalex.org/I140172145']}, {'raw_affiliation_string': "Division of Pain and Palliative Medicine, Connecticut Children's Medical Center, Hartford, CT", 'institution_ids': ['https://openalex.org/I4210101648']}, {'raw_affiliation_string': 'Department of Pediatrics, University of Connecticut School of Medicine, Farmington', 'institution_ids': ['https://openalex.org/I140172145']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5006052999', 'display_name': 'Gualberto Ruaño', 'orcid': 'https://orcid.org/0000-0002-5348-4702'}, 'institutions': [{'id': 'https://openalex.org/I1302163369', 'display_name': 'Hartford Hospital', 'ror': 'https://ror.org/00gt5xe03', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1302163369']}, {'id': 'https://openalex.org/I4210143843', 'display_name': 'Genomas (United States)', 'ror': 'https://ror.org/03yr6s895', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210143843']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Gualberto Ruaño', 'raw_affiliation_strings': ['Genetics Research Center, Hartford Hospital, Genomas Laboratory of Personalized Health Inc, Hartford, CT', 'Genetics Research Center, Hartford Hospital, Hartford'], 'affiliations': [{'raw_affiliation_string': 'Genetics Research Center, Hartford Hospital, Genomas Laboratory of Personalized Health Inc, Hartford, CT', 'institution_ids': ['https://openalex.org/I1302163369', 'https://openalex.org/I4210143843']}, {'raw_affiliation_string': 'Genetics Research Center, Hartford Hospital, Hartford', 'institution_ids': ['https://openalex.org/I1302163369']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5090675801', 'https://openalex.org/A5065969812', 'https://openalex.org/A5065563083'], 'corresponding_institution_ids': ['https://openalex.org/I140172145', 'https://openalex.org/I4210101648', 'https://openalex.org/I4210101648', 'https://openalex.org/I140172145', 'https://openalex.org/I4210101648'], 'apc_list': None, 'apc_paid': None, 'fwci': 2.226, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 14, 'citation_normalized_percentile': {'value': 0.863717, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 88, 'max': 89}, 'biblio': {'volume': '32', 'issue': '2', 'first_page': '109', 'last_page': '115'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11292', 'display_name': 'Pediatric Pain Management Techniques', 'score': 0.9981, 'subfield': {'id': 'https://openalex.org/subfields/2735', 'display_name': 'Pediatrics, Perinatology and Child Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11292', 'display_name': 'Pediatric Pain Management Techniques', 'score': 0.9981, 'subfield': {'id': 'https://openalex.org/subfields/2735', 'display_name': 'Pediatrics, Perinatology and Child Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10375', 'display_name': 'Pharmacogenetics and Drug Metabolism', 'score': 0.9971, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12547', 'display_name': 'Pharmaceutical studies and practices', 'score': 0.9959, 'subfield': {'id': 'https://openalex.org/subfields/2735', 'display_name': 'Pediatrics, Perinatology and Child Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/pharmacogenomics', 'display_name': 'Pharmacogenomics', 'score': 0.45149586}], 'concepts': [{'id': 'https://openalex.org/C55775858', 'wikidata': 'https://www.wikidata.org/wiki/Q1152227', 'display_name': 'Pharmacogenetics', 'level': 4, 'score': 0.8923601}, {'id': 'https://openalex.org/C33664856', 'wikidata': 'https://www.wikidata.org/wiki/Q3271142', 'display_name': 'CYP2D6', 'level': 4, 'score': 0.8822099}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.8558047}, {'id': 'https://openalex.org/C2780820201', 'wikidata': 'https://www.wikidata.org/wiki/Q173235', 'display_name': 'Analgesic', 'level': 2, 'score': 0.82486117}, {'id': 'https://openalex.org/C140840227', 'wikidata': 'https://www.wikidata.org/wiki/Q3737532', 'display_name': 'CYP2C19', 'level': 4, 'score': 0.7728094}, {'id': 'https://openalex.org/C197934379', 'wikidata': 'https://www.wikidata.org/wiki/Q2047938', 'display_name': 'Adverse effect', 'level': 2, 'score': 0.64592755}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.4586321}, {'id': 'https://openalex.org/C170734499', 'wikidata': 'https://www.wikidata.org/wiki/Q1152227', 'display_name': 'Pharmacogenomics', 'level': 2, 'score': 0.45149586}, {'id': 'https://openalex.org/C42219234', 'wikidata': 'https://www.wikidata.org/wiki/Q131130', 'display_name': 'Anesthesia', 'level': 1, 'score': 0.4249456}, {'id': 'https://openalex.org/C2780673598', 'wikidata': 'https://www.wikidata.org/wiki/Q285223', 'display_name': 'Genetic testing', 'level': 2, 'score': 0.4110908}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.31318158}, {'id': 'https://openalex.org/C135763542', 'wikidata': 'https://www.wikidata.org/wiki/Q106016', 'display_name': 'Genotype', 'level': 3, 'score': 0.15841845}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.07576311}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.07188052}, {'id': 'https://openalex.org/C526171541', 'wikidata': 'https://www.wikidata.org/wiki/Q407693', 'display_name': 'Cytochrome P450', 'level': 3, 'score': 0.057824403}, {'id': 'https://openalex.org/C62231903', 'wikidata': 'https://www.wikidata.org/wiki/Q1057', 'display_name': 'Metabolism', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000700', 'descriptor_name': 'Analgesics', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': True}, {'descriptor_ui': 'D064420', 'descriptor_name': 'Drug-Related Side Effects and Adverse Reactions', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D008659', 'descriptor_name': 'Metabolic Diseases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D008659', 'descriptor_name': 'Metabolic Diseases', 'qualifier_ui': 'Q000139', 'qualifier_name': 'chemically induced', 'is_major_topic': True}, {'descriptor_ui': 'D010146', 'descriptor_name': 'Pain', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D010597', 'descriptor_name': 'Pharmacogenetics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000293', 'descriptor_name': 'Adolescent', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000700', 'descriptor_name': 'Analgesics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D065731', 'descriptor_name': 'Cytochrome P-450 CYP2C19', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D065731', 'descriptor_name': 'Cytochrome P-450 CYP2C19', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D065729', 'descriptor_name': 'Cytochrome P-450 CYP2C9', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D065729', 'descriptor_name': 'Cytochrome P-450 CYP2C9', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019389', 'descriptor_name': 'Cytochrome P-450 CYP2D6', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D019389', 'descriptor_name': 'Cytochrome P-450 CYP2D6', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D064420', 'descriptor_name': 'Drug-Related Side Effects and Adverse Reactions', 'qualifier_ui': 'Q000209', 'qualifier_name': 'etiology', 'is_major_topic': False}, {'descriptor_ui': 'D064420', 'descriptor_name': 'Drug-Related Side Effects and Adverse Reactions', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005838', 'descriptor_name': 'Genotype', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008659', 'descriptor_name': 'Metabolic Diseases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010146', 'descriptor_name': 'Pain', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010146', 'descriptor_name': 'Pain', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D010146', 'descriptor_name': 'Pain', 'qualifier_ui': 'Q000145', 'qualifier_name': 'classification', 'is_major_topic': False}, {'descriptor_ui': 'D012189', 'descriptor_name': 'Retrospective Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1097/ajp.0000000000000236', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S102460418', 'display_name': 'Clinical Journal of Pain', 'issn_l': '0749-8047', 'issn': ['0749-8047', '1536-5409'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/25803758', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.49, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 38, 'referenced_works': ['https://openalex.org/W1490656360', 'https://openalex.org/W1510717844', 'https://openalex.org/W1828123165', 'https://openalex.org/W1965228291', 'https://openalex.org/W1968814844', 'https://openalex.org/W1973128804', 'https://openalex.org/W1977093684', 'https://openalex.org/W1980349304', 'https://openalex.org/W1980718719', 'https://openalex.org/W1982533755', 'https://openalex.org/W1985854946', 'https://openalex.org/W2000492372', 'https://openalex.org/W2001815145', 'https://openalex.org/W2004848360', 'https://openalex.org/W2013235742', 'https://openalex.org/W2018608742', 'https://openalex.org/W2024592581', 'https://openalex.org/W2029904859', 'https://openalex.org/W2037662227', 'https://openalex.org/W2041423270', 'https://openalex.org/W2046386752', 'https://openalex.org/W2055936731', 'https://openalex.org/W2059149449', 'https://openalex.org/W2064792065', 'https://openalex.org/W2068863582', 'https://openalex.org/W2072094720', 'https://openalex.org/W2077854844', 'https://openalex.org/W2082335023', 'https://openalex.org/W2086185646', 'https://openalex.org/W2091212941', 'https://openalex.org/W2105342833', 'https://openalex.org/W2136587464', 'https://openalex.org/W2141895799', 'https://openalex.org/W2143443866', 'https://openalex.org/W2146481987', 'https://openalex.org/W2169863987', 'https://openalex.org/W2321585154', 'https://openalex.org/W4238594081'], 'related_works': ['https://openalex.org/W4212909650', 'https://openalex.org/W2574799308', 'https://openalex.org/W2470985001', 'https://openalex.org/W2140460104', 'https://openalex.org/W2118451906', 'https://openalex.org/W2105342833', 'https://openalex.org/W2064302284', 'https://openalex.org/W2047094448', 'https://openalex.org/W2007367734', 'https://openalex.org/W1573559951'], 'abstract_inverted_index': {'Genetic': [0], 'variants': [1, 132], 'in': [2, 44, 135, 216], 'pharmacokinetic': [3], 'genes': [4, 50], 'can': [5], 'alter': [6], 'the': [7, 11, 28, 45, 53, 61, 104, 138, 160, 201], 'effectiveness': [8], 'and': [9, 48, 51, 56, 64, 78, 91, 99, 107, 122, 153, 190, 196, 210, 226, 235], 'increase': [10], 'risks': [12], 'of': [13, 21, 36, 137, 193, 204], 'using': [14], 'analgesics': [15], 'to': [16, 26, 33, 82, 114, 124, 178, 188, 200, 223, 238], 'treat': [17], 'pain.': [18, 241], 'The': [19, 172], 'purpose': [20], 'this': [22], 'retrospective': [23], 'study': [24], 'is': [25, 221], 'describe': [27], 'clinical': [29, 227], 'experiences': [30], 'that': [31], 'led': [32, 199], 'pharmacogenetic': [34, 73, 225, 233], 'testing': [35, 74, 234], 'pediatric': [37], 'pain': [38], 'management': [39], 'program': [40], 'patients': [41, 69, 119, 162, 206], 'for': [42, 72, 117, 232], 'alterations': [43, 215], 'CYP2D6,': [46, 89, 208], 'CYP2C19,': [47, 90, 209], 'CYP2C9': [49, 92, 211], 'correlate': [52], 'analgesic': [54, 58, 83, 87, 127, 194, 217, 236], 'efficacy': [55], 'adverse': [57, 86, 197], 'effects': [59, 198], 'with': [60, 163, 180, 184, 207, 214, 240], 'gene-specific': [62], 'findings': [63], 'Metabolic': [65], 'Reserve': [66], '(MR)': [67], 'index.Nineteen': [68], 'were': [70, 120, 133, 143, 147, 150, 168], 'referred': [71], 'between': [75], 'February': [76], '2010': [77], 'December': [79], '2013': [80], 'due': [81], 'ineffectiveness': [84, 195], 'or': [85], 'effects.': [88], 'functional': [93, 164], 'status': [94], 'was': [95, 155], 'inferred': [96], 'from': [97, 103, 111, 176], 'genotyping;': [98], 'MR': [100, 173], 'calculated.': [101], 'Data': [102], 'available': [105], 'inpatient': [106], 'outpatient': [108], 'medical': [109], 'records': [110], 'January': [112], '2007': [113], 'May': [115], '2014': [116], 'these': [118], 'reviewed': [121], 'extracted': [123], 'characterize': [125], 'patient': [126], 'response': [128], 'phenotype.Significant': [129], 'CYP2D6': [130, 156, 165], 'genetic': [131], 'identified': [134], '16': [136], '19': [139], '(84%)': [140], 'patients:': [141], '4': [142], 'ultra-rapid': [144], 'metabolizers,': [145, 152], '8': [146], 'deficient,': [148], '3': [149, 161], 'poor': [151], '1': [154], 'null': [157, 170], 'metabolizer.': [158], 'Of': [159], 'status,': [166], '2': [167], 'CYP2C19': [169], 'metabolizers.': [171], 'scores': [174], 'ranged': [175], '3.0': [177], '7.0,': [179], 'a': [181], 'bimodal': [182], 'distribution': [183], 'high': [185, 202], 'frequencies': [186], 'corresponding': [187], '4.0/4.5': [189], '7.0.Clinical': [191], 'evaluation': [192], 'likelihood': [203], 'identifying': [205], 'alleles': [212], 'associated': [213], 'metabolism.': [218], 'Further': [219], 'research': [220], 'needed': [222], 'integrate': [224], 'information': [228], 'into': [229], 'anticipatory': [230], 'guidance': [231], 'prescribing': [237], 'children': [239]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2047094448', 'counts_by_year': [{'year': 2022, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 1}], 'updated_date': '2025-01-10T05:57:00.057431', 'created_date': '2016-06-24'}