Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2046665203', 'doi': 'https://doi.org/10.1172/jci118787', 'title': 'Association and cosegregation of stroke with impaired endothelium-dependent vasorelaxation in stroke prone, spontaneously hypertensive rats.', 'display_name': 'Association and cosegregation of stroke with impaired endothelium-dependent vasorelaxation in stroke prone, spontaneously hypertensive rats.', 'publication_year': 1996, 'publication_date': '1996-07-15', 'ids': {'openalex': 'https://openalex.org/W2046665203', 'doi': 'https://doi.org/10.1172/jci118787', 'mag': '2046665203', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/8755632', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/507425'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1172/jci118787', 'pdf_url': 'http://www.jci.org/articles/view/118787/files/pdf', 'source': {'id': 'https://openalex.org/S114430552', 'display_name': 'Journal of Clinical Investigation', 'issn_l': '0021-9738', 'issn': ['0021-9738', '1558-8238'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320279', 'host_organization_name': 'American Society for Clinical Investigation', 'host_organization_lineage': ['https://openalex.org/P4310320279'], 'host_organization_lineage_names': ['American Society for Clinical Investigation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'http://www.jci.org/articles/view/118787/files/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5054282642', 'display_name': 'Massimo Volpe', 'orcid': 'https://orcid.org/0000-0002-9642-8380'}, 'institutions': [{'id': 'https://openalex.org/I861853513', 'display_name': 'Sapienza University of Rome', 'ror': 'https://ror.org/02be6w209', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I861853513']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'M Volpe', 'raw_affiliation_strings': ['Department of Experimental Medicine and Pathology – ‘La Sapienza’ University, Rome, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Experimental Medicine and Pathology – ‘La Sapienza’ University, Rome, Italy', 'institution_ids': ['https://openalex.org/I861853513']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015226386', 'display_name': 'Guido Iaccarino', 'orcid': 'https://orcid.org/0000-0002-8997-835X'}, 'institutions': [{'id': 'https://openalex.org/I71267560', 'display_name': 'University of Naples Federico II', 'ror': 'https://ror.org/05290cv24', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I71267560']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'G Iaccarino', 'raw_affiliation_strings': ['University of Naples-Federico II'], 'affiliations': [{'raw_affiliation_string': 'University of Naples-Federico II', 'institution_ids': ['https://openalex.org/I71267560']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085584750', 'display_name': 'Carmine Vecchione', 'orcid': 'https://orcid.org/0000-0002-2473-4565'}, 'institutions': [{'id': 'https://openalex.org/I3018288129', 'display_name': 'Istituto Neurologico Mediterraneo', 'ror': 'https://ror.org/00cpb6264', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3018288129', 'https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'C Vecchione', 'raw_affiliation_strings': ['Istituto Neurologico Mediterraneo Neuromed, Pozzilli'], 'affiliations': [{'raw_affiliation_string': 'Istituto Neurologico Mediterraneo Neuromed, Pozzilli', 'institution_ids': ['https://openalex.org/I3018288129']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075108700', 'display_name': 'Giorgio Rizzoni', 'orcid': 'https://orcid.org/0000-0002-8397-7241'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'D Rizzoni', 'raw_affiliation_strings': ['Inst. of Semiotic and Molec. Med.'], 'affiliations': [{'raw_affiliation_string': 'Inst. of Semiotic and Molec. Med.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041953373', 'display_name': 'Rosaria Russo', 'orcid': 'https://orcid.org/0000-0003-0011-5775'}, 'institutions': [{'id': 'https://openalex.org/I71267560', 'display_name': 'University of Naples Federico II', 'ror': 'https://ror.org/05290cv24', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I71267560']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'R Russo', 'raw_affiliation_strings': ['University of Naples-Federico II'], 'affiliations': [{'raw_affiliation_string': 'University of Naples-Federico II', 'institution_ids': ['https://openalex.org/I71267560']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010927128', 'display_name': 'Speranza Rubattu', 'orcid': 'https://orcid.org/0000-0001-5921-7368'}, 'institutions': [{'id': 'https://openalex.org/I2801851002', 'display_name': 'Harvard University Press', 'ror': 'https://ror.org/006v7bf86', 'country_code': 'US', 'type': 'other', 'lineage': ['https://openalex.org/I136199984', 'https://openalex.org/I2801851002']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'S Rubattu', 'raw_affiliation_strings': ['Harvard University'], 'affiliations': [{'raw_affiliation_string': 'Harvard University', 'institution_ids': ['https://openalex.org/I2801851002']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010700645', 'display_name': 'Gianluigi Condorelli', 'orcid': 'https://orcid.org/0000-0003-0481-6843'}, 'institutions': [{'id': 'https://openalex.org/I3018288129', 'display_name': 'Istituto Neurologico Mediterraneo', 'ror': 'https://ror.org/00cpb6264', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3018288129', 'https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'G Condorelli', 'raw_affiliation_strings': ['Istituto Neurologico Mediterraneo Neuromed, Pozzilli'], 'affiliations': [{'raw_affiliation_string': 'Istituto Neurologico Mediterraneo Neuromed, Pozzilli', 'institution_ids': ['https://openalex.org/I3018288129']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046987906', 'display_name': 'Ursula Ganten', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I205582932', 'display_name': 'Max Delbrück Center', 'ror': 'https://ror.org/04p5ggc03', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I1305996414', 'https://openalex.org/I205582932']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'U Ganten', 'raw_affiliation_strings': ['Max-Delbrück-Center for Molecular Medicine;'], 'affiliations': [{'raw_affiliation_string': 'Max-Delbrück-Center for Molecular Medicine;', 'institution_ids': ['https://openalex.org/I205582932']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008231286', 'display_name': 'Detlev Ganten', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I205582932', 'display_name': 'Max Delbrück Center', 'ror': 'https://ror.org/04p5ggc03', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I1305996414', 'https://openalex.org/I205582932']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'D Ganten', 'raw_affiliation_strings': ['Max-Delbrück-Center for Molecular Medicine;'], 'affiliations': [{'raw_affiliation_string': 'Max-Delbrück-Center for Molecular Medicine;', 'institution_ids': ['https://openalex.org/I205582932']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5020371820', 'display_name': 'Bruno Trimarco', 'orcid': 'https://orcid.org/0000-0002-0701-6449'}, 'institutions': [{'id': 'https://openalex.org/I71267560', 'display_name': 'University of Naples Federico II', 'ror': 'https://ror.org/05290cv24', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I71267560']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'B Trimarco', 'raw_affiliation_strings': ['University of Naples-Federico II'], 'affiliations': [{'raw_affiliation_string': 'University of Naples-Federico II', 'institution_ids': ['https://openalex.org/I71267560']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5060041987', 'display_name': 'Klaus Lindpaintner', 'orcid': 'https://orcid.org/0000-0002-6923-4900'}, 'institutions': [{'id': 'https://openalex.org/I2801851002', 'display_name': 'Harvard University Press', 'ror': 'https://ror.org/006v7bf86', 'country_code': 'US', 'type': 'other', 'lineage': ['https://openalex.org/I136199984', 'https://openalex.org/I2801851002']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'K Lindpaintner', 'raw_affiliation_strings': ['Harvard University'], 'affiliations': [{'raw_affiliation_string': 'Harvard University', 'institution_ids': ['https://openalex.org/I2801851002']}]}], 'countries_distinct_count': 3, 'institutions_distinct_count': 5, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 5200, 'currency': 'USD', 'value_usd': 5200, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 3.265, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 89, 'citation_normalized_percentile': {'value': 0.909703, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '98', 'issue': '2', 'first_page': '256', 'last_page': '261'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11457', 'display_name': 'Brown Adipose Tissue Function and Physiology', 'score': 0.9971, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11457', 'display_name': 'Brown Adipose Tissue Function and Physiology', 'score': 0.9971, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13551', 'display_name': 'Physiology and Pathophysiology of Carnosine', 'score': 0.9946, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10489', 'display_name': 'Neuroendocrine Regulation of Appetite and Body Weight', 'score': 0.9905, 'subfield': {'id': 'https://openalex.org/subfields/2807', 'display_name': 'Endocrine and Autonomic Systems'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/stroke', 'display_name': 'Stroke (engine)', 'score': 0.8085122}, {'id': 'https://openalex.org/keywords/endothelial-dysfunction', 'display_name': 'Endothelial dysfunction', 'score': 0.49688056}, {'id': 'https://openalex.org/keywords/metabolic-regulation', 'display_name': 'Metabolic Regulation', 'score': 0.435065}, {'id': 'https://openalex.org/keywords/thoracic-aorta', 'display_name': 'Thoracic aorta', 'score': 0.4250309}, {'id': 'https://openalex.org/keywords/spontaneously-hypertensive-rat', 'display_name': 'Spontaneously hypertensive rat', 'score': 0.4207072}], 'concepts': [{'id': 'https://openalex.org/C2780645631', 'wikidata': 'https://www.wikidata.org/wiki/Q671554', 'display_name': 'Stroke (engine)', 'level': 2, 'score': 0.8085122}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.7611469}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.719872}, {'id': 'https://openalex.org/C2776992346', 'wikidata': 'https://www.wikidata.org/wiki/Q111140', 'display_name': 'Endothelium', 'level': 2, 'score': 0.6412326}, {'id': 'https://openalex.org/C84393581', 'wikidata': 'https://www.wikidata.org/wiki/Q82642', 'display_name': 'Blood pressure', 'level': 2, 'score': 0.62858486}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.58043516}, {'id': 'https://openalex.org/C120770815', 'wikidata': 'https://www.wikidata.org/wiki/Q14859627', 'display_name': 'Vasodilation', 'level': 2, 'score': 0.52964425}, {'id': 'https://openalex.org/C2780972559', 'wikidata': 'https://www.wikidata.org/wiki/Q550061', 'display_name': 'Endothelial dysfunction', 'level': 2, 'score': 0.49688056}, {'id': 'https://openalex.org/C2779980429', 'wikidata': 'https://www.wikidata.org/wiki/Q101004', 'display_name': 'Aorta', 'level': 2, 'score': 0.47851217}, {'id': 'https://openalex.org/C2776864027', 'wikidata': 'https://www.wikidata.org/wiki/Q615993', 'display_name': 'Thoracic aorta', 'level': 3, 'score': 0.4250309}, {'id': 'https://openalex.org/C2778086073', 'wikidata': 'https://www.wikidata.org/wiki/Q7579064', 'display_name': 'Spontaneously hypertensive rat', 'level': 3, 'score': 0.4207072}, {'id': 'https://openalex.org/C78519656', 'wikidata': 'https://www.wikidata.org/wiki/Q101333', 'display_name': 'Mechanical engineering', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C127413603', 'wikidata': 'https://www.wikidata.org/wiki/Q11023', 'display_name': 'Engineering', 'level': 0, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001013', 'descriptor_name': 'Aorta, Thoracic', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': True}, {'descriptor_ui': 'D001488', 'descriptor_name': 'Basilar Artery', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': True}, {'descriptor_ui': 'D002561', 'descriptor_name': 'Cerebrovascular Disorders', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': True}, {'descriptor_ui': 'D004730', 'descriptor_name': 'Endothelium, Vascular', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': True}, {'descriptor_ui': 'D006973', 'descriptor_name': 'Hypertension', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': True}, {'descriptor_ui': 'D009131', 'descriptor_name': 'Muscle, Smooth, Vascular', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': True}, {'descriptor_ui': 'D014664', 'descriptor_name': 'Vasodilation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000109', 'descriptor_name': 'Acetylcholine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000109', 'descriptor_name': 'Acetylcholine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001013', 'descriptor_name': 'Aorta, Thoracic', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D001013', 'descriptor_name': 'Aorta, Thoracic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001013', 'descriptor_name': 'Aorta, Thoracic', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D001488', 'descriptor_name': 'Basilar Artery', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D001488', 'descriptor_name': 'Basilar Artery', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001794', 'descriptor_name': 'Blood Pressure', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002561', 'descriptor_name': 'Cerebrovascular Disorders', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D002561', 'descriptor_name': 'Cerebrovascular Disorders', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002561', 'descriptor_name': 'Cerebrovascular Disorders', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D003433', 'descriptor_name': 'Crosses, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004198', 'descriptor_name': 'Disease Susceptibility', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004730', 'descriptor_name': 'Endothelium, Vascular', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D004730', 'descriptor_name': 'Endothelium, Vascular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006339', 'descriptor_name': 'Heart Rate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006973', 'descriptor_name': 'Hypertension', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D006973', 'descriptor_name': 'Hypertension', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D006973', 'descriptor_name': 'Hypertension', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D066298', 'descriptor_name': 'In Vitro Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009119', 'descriptor_name': 'Muscle Contraction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009119', 'descriptor_name': 'Muscle Contraction', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D009131', 'descriptor_name': 'Muscle, Smooth, Vascular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009131', 'descriptor_name': 'Muscle, Smooth, Vascular', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D009131', 'descriptor_name': 'Muscle, Smooth, Vascular', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D005996', 'descriptor_name': 'Nitroglycerin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005996', 'descriptor_name': 'Nitroglycerin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D009599', 'descriptor_name': 'Nitroprusside', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D009599', 'descriptor_name': 'Nitroprusside', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011918', 'descriptor_name': 'Rats, Inbred SHR', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011919', 'descriptor_name': 'Rats, Inbred Strains', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012701', 'descriptor_name': 'Serotonin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D012701', 'descriptor_name': 'Serotonin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013373', 'descriptor_name': 'Substance P', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D013373', 'descriptor_name': 'Substance P', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014664', 'descriptor_name': 'Vasodilation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1172/jci118787', 'pdf_url': 'http://www.jci.org/articles/view/118787/files/pdf', 'source': {'id': 'https://openalex.org/S114430552', 'display_name': 'Journal of Clinical Investigation', 'issn_l': '0021-9738', 'issn': ['0021-9738', '1558-8238'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320279', 'host_organization_name': 'American Society for Clinical Investigation', 'host_organization_lineage': ['https://openalex.org/P4310320279'], 'host_organization_lineage_names': ['American Society for Clinical Investigation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc507425', 'pdf_url': 'https://europepmc.org/articles/pmc507425?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://edoc.mdc-berlin.de/2025/1/2025oa.pdf', 'pdf_url': 'http://edoc.mdc-berlin.de/2025/1/2025oa.pdf', 'source': {'id': 'https://openalex.org/S4306400224', 'display_name': 'MDC Repository (Max-Delbrueck-Center for Molecular Medicine)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I149899117', 'host_organization_name': 'Max Planck Society', 'host_organization_lineage': ['https://openalex.org/I149899117'], 'host_organization_lineage_names': ['Max Planck Society'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC507425', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/8755632', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1172/jci118787', 'pdf_url': 'http://www.jci.org/articles/view/118787/files/pdf', 'source': {'id': 'https://openalex.org/S114430552', 'display_name': 'Journal of Clinical Investigation', 'issn_l': '0021-9738', 'issn': ['0021-9738', '1558-8238'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320279', 'host_organization_name': 'American Society for Clinical Investigation', 'host_organization_lineage': ['https://openalex.org/P4310320279'], 'host_organization_lineage_names': ['American Society for Clinical Investigation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.84, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 35, 'referenced_works': ['https://openalex.org/W1839922051', 'https://openalex.org/W1929009802', 'https://openalex.org/W1964657445', 'https://openalex.org/W1970445852', 'https://openalex.org/W1997234857', 'https://openalex.org/W2003264729', 'https://openalex.org/W2008661724', 'https://openalex.org/W2015996189', 'https://openalex.org/W2016585399', 'https://openalex.org/W2020121600', 'https://openalex.org/W2025552293', 'https://openalex.org/W2035278369', 'https://openalex.org/W2040949241', 'https://openalex.org/W2058878434', 'https://openalex.org/W2064906534', 'https://openalex.org/W2069915524', 'https://openalex.org/W2070629776', 'https://openalex.org/W2090498221', 'https://openalex.org/W2104565146', 'https://openalex.org/W2113220448', 'https://openalex.org/W2114544525', 'https://openalex.org/W2120710290', 'https://openalex.org/W2127203967', 'https://openalex.org/W2130816762', 'https://openalex.org/W2133040751', 'https://openalex.org/W2140374830', 'https://openalex.org/W2147554218', 'https://openalex.org/W2163285329', 'https://openalex.org/W2165521770', 'https://openalex.org/W2265110805', 'https://openalex.org/W2331879659', 'https://openalex.org/W2332938287', 'https://openalex.org/W2409726275', 'https://openalex.org/W2912155580', 'https://openalex.org/W96819370'], 'related_works': ['https://openalex.org/W4388913750', 'https://openalex.org/W2977425909', 'https://openalex.org/W2899335053', 'https://openalex.org/W2799945650', 'https://openalex.org/W2565635511', 'https://openalex.org/W2548052441', 'https://openalex.org/W2028770962', 'https://openalex.org/W2025791617', 'https://openalex.org/W2022809694', 'https://openalex.org/W1985874031'], 'abstract_inverted_index': {'While': [0], 'hypertension': [1], 'is': [2, 10], 'a': [3, 72, 77, 153, 188], 'major': [4], 'risk': [5], 'factor': [6], 'for': [7, 63], 'stroke,': [8], 'it': [9], 'not': [11, 24], 'its': [12], 'sole': [13], 'determinant.': [14], 'Despite': [15], 'similar': [16, 87, 107], 'blood': [17], 'pressures,': [18], 'spontaneously': [19, 34], 'hypertensive': [20, 35], 'rats': [21, 36, 81, 149, 161], '(SHR)': [22], 'do': [23], 'share': [25], 'the': [26, 58, 64, 69, 198], 'predisposition': [27], 'to': [28, 112, 126, 163], 'cerebrovascular': [29], 'disease': [30], 'typical': [31], 'of': [32, 66, 74, 79, 98, 147, 170, 177, 192, 200], 'stroke-prone': [33, 75, 183], '(SHRSP).': [37], 'We': [38], 'investigated': [39], 'vascular': [40, 92, 195], 'function': [41], 'in': [42, 50, 88, 117, 124, 134, 145, 197], 'male': [43], 'SHR': [44, 158], 'and': [45, 76, 101, 109, 114, 168, 174, 182], 'SHRSP': [46, 135, 181], 'as': [47, 49], 'well': [48], 'SHRSP/SHR-F2': [51], 'hybrid': [52, 70], 'animals.': [53], 'Animals': [54], 'were': [55, 82, 143], 'maintained': [56], 'on': [57, 95], 'appropriate': [59], 'dietary': [60], 'regimen': [61], 'necessary': [62], 'manifestation': [65], 'stroke.': [67, 164, 201], 'Among': [68], 'animals,': [71], 'group': [73, 78], 'stroke-resistant': [80], 'selected.': [83], 'Blood': [84], 'pressure': [85], 'was': [86, 131], 'all': [89, 118], 'groups.': [90, 119], 'Endothelium-independent': [91], 'reactivity': [93], 'tested': [94], 'isolated': [96], 'rings': [97], 'thoracic': [99], 'aorta': [100], 'basilar': [102], 'artery': [103], 'after': [104], 'death': [105], 'showed': [106], 'contractile': [108], 'dilatory': [110], 'responses': [111, 142], 'serotonin': [113], 'nitroglycerin,': [115], 'respectively,': [116, 186], 'In': [120], 'contrast,': [121], 'endothelium-dependent': [122, 178, 194], 'relaxation,': [123], 'response': [125], 'acetylcholine': [127], 'or': [128, 159], 'substance': [129], 'P,': [130], 'markedly': [132], 'reduced': [133, 140], 'compared': [136, 156], 'with': [137, 157, 172], 'SHR.': [138], 'Similarly,': [139], 'vasodilatory': [141], 'present': [144], 'aortae': [146], 'F2': [148, 160, 184], 'that': [150], 'had': [151], 'suffered': [152], 'stroke': [154, 171], 'when': [155], 'resistant': [162], 'The': [165], 'observed': [166], 'association': [167], 'cosegregation': [169], 'significant': [173], 'specific': [175], 'impairment': [176], 'vasorelaxation': [179], 'among': [180], 'hybrids,': [185], 'suggest': [187], 'potential': [189], 'causal': [190], 'role': [191], 'altered': [193], 'relaxation': [196], 'pathogenesis': [199]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2046665203', 'counts_by_year': [{'year': 2023, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-08-15T06:49:32.103078', 'created_date': '2016-06-24'}