Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2046638602', 'doi': 'https://doi.org/10.1038/sj.jcbfm.9600146', 'title': 'Kinetic Modeling of Amyloid Binding in Humans using PET Imaging and Pittsburgh Compound-B', 'display_name': 'Kinetic Modeling of Amyloid Binding in Humans using PET Imaging and Pittsburgh Compound-B', 'publication_year': 2005, 'publication_date': '2005-06-08', 'ids': {'openalex': 'https://openalex.org/W2046638602', 'doi': 'https://doi.org/10.1038/sj.jcbfm.9600146', 'mag': '2046638602', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/15944649'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1038/sj.jcbfm.9600146', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S89339265', 'display_name': 'Journal of Cerebral Blood Flow & Metabolism', 'issn_l': '0271-678X', 'issn': ['0271-678X', '1559-7016'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320017', 'host_organization_name': 'SAGE Publishing', 'host_organization_lineage': ['https://openalex.org/P4310320017'], 'host_organization_lineage_names': ['SAGE Publishing'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5074758454', 'display_name': 'Julie C. Price', 'orcid': 'https://orcid.org/0000-0001-7131-4865'}, 'institutions': [{'id': 'https://openalex.org/I170201317', 'display_name': 'University of Pittsburgh', 'ror': 'https://ror.org/01an3r305', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I170201317']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Julie C Price', 'raw_affiliation_strings': ['Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA', 'institution_ids': ['https://openalex.org/I170201317']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036841670', 'display_name': 'William E. Klunk', 'orcid': 'https://orcid.org/0000-0001-5512-0251'}, 'institutions': [{'id': 'https://openalex.org/I170201317', 'display_name': 'University of Pittsburgh', 'ror': 'https://ror.org/01an3r305', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I170201317']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'William E Klunk', 'raw_affiliation_strings': ['2Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.'], 'affiliations': [{'raw_affiliation_string': '2Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.', 'institution_ids': ['https://openalex.org/I170201317']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068192630', 'display_name': 'Brian J. Lopresti', 'orcid': 'https://orcid.org/0000-0002-0595-0203'}, 'institutions': [{'id': 'https://openalex.org/I170201317', 'display_name': 'University of Pittsburgh', 'ror': 'https://ror.org/01an3r305', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I170201317']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Brian J Lopresti', 'raw_affiliation_strings': ['1Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA'], 'affiliations': [{'raw_affiliation_string': '1Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA', 'institution_ids': ['https://openalex.org/I170201317']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100930338', 'display_name': 'Xueling Lu', 'orcid': 'https://orcid.org/0009-0004-3492-0419'}, 'institutions': [{'id': 'https://openalex.org/I170201317', 'display_name': 'University of Pittsburgh', 'ror': 'https://ror.org/01an3r305', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I170201317']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Xueling Lu', 'raw_affiliation_strings': ['1Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA'], 'affiliations': [{'raw_affiliation_string': '1Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA', 'institution_ids': ['https://openalex.org/I170201317']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5060175911', 'display_name': 'Jessica A. Hoge', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I170201317', 'display_name': 'University of Pittsburgh', 'ror': 'https://ror.org/01an3r305', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I170201317']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jessica A Hoge', 'raw_affiliation_strings': ['1Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA'], 'affiliations': [{'raw_affiliation_string': '1Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA', 'institution_ids': ['https://openalex.org/I170201317']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040176146', 'display_name': 'Scott K. Ziolko', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I170201317', 'display_name': 'University of Pittsburgh', 'ror': 'https://ror.org/01an3r305', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I170201317']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Scott K Ziolko', 'raw_affiliation_strings': ['1Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA'], 'affiliations': [{'raw_affiliation_string': '1Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA', 'institution_ids': ['https://openalex.org/I170201317']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064352152', 'display_name': 'Daniel P. Holt', 'orcid': 'https://orcid.org/0000-0001-5793-198X'}, 'institutions': [{'id': 'https://openalex.org/I170201317', 'display_name': 'University of Pittsburgh', 'ror': 'https://ror.org/01an3r305', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I170201317']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Daniel P Holt', 'raw_affiliation_strings': ['1Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA'], 'affiliations': [{'raw_affiliation_string': '1Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA', 'institution_ids': ['https://openalex.org/I170201317']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5066006962', 'display_name': 'Carolyn C. Meltzer', 'orcid': 'https://orcid.org/0000-0003-1127-9783'}, 'institutions': [{'id': 'https://openalex.org/I170201317', 'display_name': 'University of Pittsburgh', 'ror': 'https://ror.org/01an3r305', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I170201317']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Carolyn C Meltzer', 'raw_affiliation_strings': ['1Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA'], 'affiliations': [{'raw_affiliation_string': '1Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA', 'institution_ids': ['https://openalex.org/I170201317']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084618289', 'display_name': 'Steven T. DeKosky', 'orcid': 'https://orcid.org/0000-0003-3743-2758'}, 'institutions': [{'id': 'https://openalex.org/I170201317', 'display_name': 'University of Pittsburgh', 'ror': 'https://ror.org/01an3r305', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I170201317']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Steven T DeKosky', 'raw_affiliation_strings': ['3Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA'], 'affiliations': [{'raw_affiliation_string': '3Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA', 'institution_ids': ['https://openalex.org/I170201317']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5029440312', 'display_name': 'Chester A. Mathis', 'orcid': 'https://orcid.org/0000-0001-9811-0950'}, 'institutions': [{'id': 'https://openalex.org/I170201317', 'display_name': 'University of Pittsburgh', 'ror': 'https://ror.org/01an3r305', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I170201317']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Chester A Mathis', 'raw_affiliation_strings': ['1Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA'], 'affiliations': [{'raw_affiliation_string': '1Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA', 'institution_ids': ['https://openalex.org/I170201317']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 28.457, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 664, 'citation_normalized_percentile': {'value': 0.999924, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '25', 'issue': '11', 'first_page': '1528', 'last_page': '1547'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11304', 'display_name': 'Diffusion Magnetic Resonance Imaging', 'score': 0.9961, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11304', 'display_name': 'Diffusion Magnetic Resonance Imaging', 'score': 0.9961, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10009', 'display_name': "Diagnosis and Management of Alzheimer's Disease", 'score': 0.9957, 'subfield': {'id': 'https://openalex.org/subfields/2738', 'display_name': 'Psychiatry and Mental health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10086', 'display_name': "Mechanisms of Alzheimer's Disease", 'score': 0.993, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/pittsburgh-compound-b', 'display_name': 'Pittsburgh compound B', 'score': 0.92530084}, {'id': 'https://openalex.org/keywords/neuroimaging', 'display_name': 'Neuroimaging', 'score': 0.540819}, {'id': 'https://openalex.org/keywords/axonal-tracking', 'display_name': 'Axonal Tracking', 'score': 0.517937}, {'id': 'https://openalex.org/keywords/protein-misfolding', 'display_name': 'Protein Misfolding', 'score': 0.50634}, {'id': 'https://openalex.org/keywords/amyloid-hypothesis', 'display_name': 'Amyloid Hypothesis', 'score': 0.503103}, {'id': 'https://openalex.org/keywords/posterior-cingulate', 'display_name': 'Posterior cingulate', 'score': 0.48530954}, {'id': 'https://openalex.org/keywords/binding-potential', 'display_name': 'Binding potential', 'score': 0.45213148}, {'id': 'https://openalex.org/keywords/amyloid', 'display_name': 'Amyloid (mycology)', 'score': 0.44808593}], 'concepts': [{'id': 'https://openalex.org/C2781073650', 'wikidata': 'https://www.wikidata.org/wiki/Q4047010', 'display_name': 'Pittsburgh compound B', 'level': 4, 'score': 0.92530084}, {'id': 'https://openalex.org/C2989005', 'wikidata': 'https://www.wikidata.org/wiki/Q214963', 'display_name': 'Nuclear medicine', 'level': 1, 'score': 0.67835397}, {'id': 'https://openalex.org/C2775842073', 'wikidata': 'https://www.wikidata.org/wiki/Q208376', 'display_name': 'Positron emission tomography', 'level': 2, 'score': 0.62394404}, {'id': 'https://openalex.org/C143409427', 'wikidata': 'https://www.wikidata.org/wiki/Q161238', 'display_name': 'Magnetic resonance imaging', 'level': 2, 'score': 0.5146123}, {'id': 'https://openalex.org/C2778733324', 'wikidata': 'https://www.wikidata.org/wiki/Q2998088', 'display_name': 'Posterior cingulate', 'level': 3, 'score': 0.48530954}, {'id': 'https://openalex.org/C54170458', 'wikidata': 'https://www.wikidata.org/wiki/Q663554', 'display_name': 'Voxel', 'level': 2, 'score': 0.4563305}, {'id': 'https://openalex.org/C60592354', 'wikidata': 'https://www.wikidata.org/wiki/Q4914018', 'display_name': 'Binding potential', 'level': 3, 'score': 0.45213148}, {'id': 'https://openalex.org/C2984915365', 'wikidata': 'https://www.wikidata.org/wiki/Q5141203', 'display_name': 'Cognitive impairment', 'level': 3, 'score': 0.44866666}, {'id': 'https://openalex.org/C2777633098', 'wikidata': 'https://www.wikidata.org/wiki/Q2736051', 'display_name': 'Amyloid (mycology)', 'level': 2, 'score': 0.44808593}, {'id': 'https://openalex.org/C502032728', 'wikidata': 'https://www.wikidata.org/wiki/Q11081', 'display_name': "Alzheimer's disease", 'level': 3, 'score': 0.44199428}, {'id': 'https://openalex.org/C2781441883', 'wikidata': 'https://www.wikidata.org/wiki/Q1632835', 'display_name': 'Precuneus', 'level': 3, 'score': 0.43921268}, {'id': 'https://openalex.org/C58693492', 'wikidata': 'https://www.wikidata.org/wiki/Q551875', 'display_name': 'Neuroimaging', 'level': 2, 'score': 0.42719555}, {'id': 'https://openalex.org/C15744967', 'wikidata': 'https://www.wikidata.org/wiki/Q9418', 'display_name': 'Psychology', 'level': 0, 'score': 0.40888053}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.36537024}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.35482877}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.27766424}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.2515958}, {'id': 'https://openalex.org/C169900460', 'wikidata': 'https://www.wikidata.org/wiki/Q2200417', 'display_name': 'Cognition', 'level': 2, 'score': 0.23624685}, {'id': 'https://openalex.org/C126838900', 'wikidata': 'https://www.wikidata.org/wiki/Q77604', 'display_name': 'Radiology', 'level': 1, 'score': 0.15743893}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.15626189}], 'mesh': [{'descriptor_ui': 'D000544', 'descriptor_name': 'Alzheimer Disease', 'qualifier_ui': 'Q000000981', 'qualifier_name': 'diagnostic imaging', 'is_major_topic': True}, {'descriptor_ui': 'D000682', 'descriptor_name': 'Amyloid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000814', 'descriptor_name': 'Aniline Compounds', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D002525', 'descriptor_name': 'Cerebellar Cortex', 'qualifier_ui': 'Q000000981', 'qualifier_name': 'diagnostic imaging', 'is_major_topic': True}, {'descriptor_ui': 'D007091', 'descriptor_name': 'Image Processing, Computer-Assisted', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D049268', 'descriptor_name': 'Positron-Emission Tomography', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D013844', 'descriptor_name': 'Thiazoles', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000369', 'descriptor_name': 'Aged, 80 and over', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000544', 'descriptor_name': 'Alzheimer Disease', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000544', 'descriptor_name': 'Alzheimer Disease', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000682', 'descriptor_name': 'Amyloid', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000814', 'descriptor_name': 'Aniline Compounds', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000814', 'descriptor_name': 'Aniline Compounds', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': False}, {'descriptor_ui': 'D002525', 'descriptor_name': 'Cerebellar Cortex', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002525', 'descriptor_name': 'Cerebellar Cortex', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007091', 'descriptor_name': 'Image Processing, Computer-Assisted', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D007700', 'descriptor_name': 'Kinetics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008569', 'descriptor_name': 'Memory Disorders', 'qualifier_ui': 'Q000000981', 'qualifier_name': 'diagnostic imaging', 'is_major_topic': False}, {'descriptor_ui': 'D008569', 'descriptor_name': 'Memory Disorders', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008569', 'descriptor_name': 'Memory Disorders', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049268', 'descriptor_name': 'Positron-Emission Tomography', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011859', 'descriptor_name': 'Radiography', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013844', 'descriptor_name': 'Thiazoles', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': False}, {'descriptor_ui': 'D013844', 'descriptor_name': 'Thiazoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1038/sj.jcbfm.9600146', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S89339265', 'display_name': 'Journal of Cerebral Blood Flow & Metabolism', 'issn_l': '0271-678X', 'issn': ['0271-678X', '1559-7016'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320017', 'host_organization_name': 'SAGE Publishing', 'host_organization_lineage': ['https://openalex.org/P4310320017'], 'host_organization_lineage_names': ['SAGE Publishing'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/15944649', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 78, 'referenced_works': ['https://openalex.org/W1556008598', 'https://openalex.org/W1771725737', 'https://openalex.org/W1821065636', 'https://openalex.org/W182231919', 'https://openalex.org/W1835478781', 'https://openalex.org/W1847168837', 'https://openalex.org/W1963568158', 'https://openalex.org/W1963934004', 'https://openalex.org/W1967823816', 'https://openalex.org/W1970567308', 'https://openalex.org/W1975427503', 'https://openalex.org/W1978663763', 'https://openalex.org/W1980842500', 'https://openalex.org/W1984754451', 'https://openalex.org/W1985603549', 'https://openalex.org/W1986159971', 'https://openalex.org/W1991952617', 'https://openalex.org/W1994653867', 'https://openalex.org/W2000706612', 'https://openalex.org/W2001434260', 'https://openalex.org/W2004593644', 'https://openalex.org/W2010543503', 'https://openalex.org/W2019503269', 'https://openalex.org/W2023118385', 'https://openalex.org/W2024940817', 'https://openalex.org/W2024965845', 'https://openalex.org/W2029923284', 'https://openalex.org/W2035837210', 'https://openalex.org/W2051809205', 'https://openalex.org/W2052094195', 'https://openalex.org/W2054089714', 'https://openalex.org/W2054344703', 'https://openalex.org/W2054929374', 'https://openalex.org/W2056237956', 'https://openalex.org/W2056833274', 'https://openalex.org/W2058747520', 'https://openalex.org/W2059875787', 'https://openalex.org/W2063017390', 'https://openalex.org/W2064865731', 'https://openalex.org/W2065535274', 'https://openalex.org/W2065592408', 'https://openalex.org/W2069201769', 'https://openalex.org/W2082411172', 'https://openalex.org/W2085459598', 'https://openalex.org/W2091088809', 'https://openalex.org/W2091874081', 'https://openalex.org/W2096998012', 'https://openalex.org/W2097485341', 'https://openalex.org/W2100379723', 'https://openalex.org/W2105381419', 'https://openalex.org/W2111352290', 'https://openalex.org/W2113708991', 'https://openalex.org/W2119823987', 'https://openalex.org/W2123021161', 'https://openalex.org/W2125591528', 'https://openalex.org/W2141403362', 'https://openalex.org/W2142635246', 'https://openalex.org/W2144279364', 'https://openalex.org/W2146729934', 'https://openalex.org/W2149614271', 'https://openalex.org/W2153631628', 'https://openalex.org/W2154170073', 'https://openalex.org/W2156220037', 'https://openalex.org/W2157299685', 'https://openalex.org/W2159789463', 'https://openalex.org/W2162426787', 'https://openalex.org/W2162978906', 'https://openalex.org/W2167720733', 'https://openalex.org/W2170994321', 'https://openalex.org/W2183640792', 'https://openalex.org/W2325343629', 'https://openalex.org/W2417368727', 'https://openalex.org/W2543962677', 'https://openalex.org/W4247701771', 'https://openalex.org/W4251308908', 'https://openalex.org/W4299503428', 'https://openalex.org/W630092384', 'https://openalex.org/W657611509'], 'related_works': ['https://openalex.org/W4241424657', 'https://openalex.org/W2664282508', 'https://openalex.org/W2538776211', 'https://openalex.org/W2134858198', 'https://openalex.org/W2130540257', 'https://openalex.org/W2114319021', 'https://openalex.org/W2074957274', 'https://openalex.org/W2060363468', 'https://openalex.org/W1994233627', 'https://openalex.org/W1977651507'], 'abstract_inverted_index': {'A': [0], 'valid': [1], 'quantitative': [2, 48, 227], 'imaging': [3, 49, 230], 'method': [4], 'for': [5, 32, 88, 197, 209, 239], 'the': [6, 117, 140, 195, 198, 243], 'measurement': [7], 'of': [8, 54], 'amyloid': [9], 'deposition': [10], 'in': [11, 66, 162, 173, 188], 'humans': [12], 'could': [13], 'improve': [14], "Alzheimer's": [15], 'disease': [16, 245], '(AD)': [17], 'diagnosis': [18], 'and': [19, 52, 71, 75, 92, 106, 132, 207, 213], 'antiamyloid': [20], 'therapy': [21], 'assessment.': [22], 'Our': [23], 'group': [24], 'developed': [25], 'Pittsburgh': [26, 61], 'Compound-B': [27, 62], '(PIB),': [28], 'an': [29], 'amyloid-binding': [30], 'radiotracer,': [31], 'positron': [33], 'emission': [34], 'tomography': [35], '(PET).': [36], 'The': [37, 170, 181, 191], 'current': [38], 'study': [39, 218], 'was': [40, 128, 149, 160, 185, 194], 'aimed': [41], 'to': [42, 116, 121, 167, 225, 235], 'further': [43], 'validate': [44, 236], 'PIB': [45, 147, 171, 199, 228], 'PET': [46, 200, 229], 'through': [47], '(arterial': [50], 'input)': [51], 'inclusion': [53], 'subjects': [55, 74, 77, 152, 175], 'with': [56], 'mild': [57], 'cognitive': [58], 'impairment': [59], '(MCI).': [60], 'studies': [63, 212, 231], 'were': [64, 78, 86, 102, 114, 143], 'performed': [65], 'five': [67, 69, 72, 76], 'AD,': [68], 'MCI,': [70], 'control': [73], 'retested': [79], 'within': [80], '20': [81], 'days.': [82], 'Magnetic': [83], 'resonance': [84], 'images': [85], 'acquired': [87], 'partial': [89], 'volume': [90, 111], 'correction': [91], 'region-of-interest': [93], 'definition': [94], '(e.g.,': [95, 136], 'posterior': [96], 'cingulate:': [97], 'PCG;': [98], 'cerebellum:': [99], 'CER).': [100], 'Data': [101], 'analyzed': [103], 'using': [104], 'compartmental': [105, 131], 'graphical': [107], 'approaches.': [108], 'Regional': [109], 'distribution': [110], '(DV)': [112], 'values': [113, 135], 'normalized': [115], 'reference': [118], 'region': [119], '(CER)': [120], 'yield': [122], 'DV': [123], 'ratios': [124], '(DVRs).': [125], 'Good': [126], 'agreement': [127], 'observed': [129, 161], 'between': [130], 'Logan': [133, 141, 154, 192], 'DVR': [134], 'PCG:': [137], 'r=0.89,': [138], 'slope=0.91);': [139], 'results': [142], 'less': [144], 'variable.': [145], 'Nonspecific': [146], 'retention': [148, 159, 172], 'similar': [150], 'across': [151, 242], '(n=15,': [153], 'CER': [155], 'DV:': [156], '3.63+/-0.48).': [157], 'Greater': [158], 'AD': [163, 244], 'cortical': [164], 'areas,': [165], 'relative': [166], 'controls': [168], '(P<0.05).': [169], 'MCI': [174], 'appeared': [176], 'either': [177], "'AD-like'": [178], 'or': [179], "'control-like'.": [180], 'mean': [182], 'test/retest': [183], 'variation': [184], 'approximately': [186], '6%': [187], 'primary': [189], 'areas-of-interest.': [190], 'analysis': [193], 'method-of-choice': [196], 'data': [201], 'as': [202], 'it': [203, 222], 'proved': [204], 'stable,': [205], 'valid,': [206], 'promising': [208], 'future': [210], 'larger': [211], 'voxel-based': [214], 'statistical': [215], 'analyses.': [216], 'This': [217], 'also': [219], 'showed': [220], 'that': [221, 232], 'is': [223], 'feasible': [224], 'perform': [226], 'are': [233], 'needed': [234], 'simpler': [237], 'methods': [238], 'routine': [240], 'use': [241], 'spectrum.': [246]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2046638602', 'counts_by_year': [{'year': 2024, 'cited_by_count': 13}, {'year': 2023, 'cited_by_count': 11}, {'year': 2022, 'cited_by_count': 22}, {'year': 2021, 'cited_by_count': 28}, {'year': 2020, 'cited_by_count': 30}, {'year': 2019, 'cited_by_count': 33}, {'year': 2018, 'cited_by_count': 25}, {'year': 2017, 'cited_by_count': 41}, {'year': 2016, 'cited_by_count': 31}, {'year': 2015, 'cited_by_count': 53}, {'year': 2014, 'cited_by_count': 44}, {'year': 2013, 'cited_by_count': 52}, {'year': 2012, 'cited_by_count': 52}], 'updated_date': '2024-09-11T20:09:54.551715', 'created_date': '2016-06-24'}