Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2046609408', 'doi': 'https://doi.org/10.1371/journal.pone.0015063', 'title': 'Visual Responses in Mice Lacking Critical Components of All Known Retinal Phototransduction Cascades', 'display_name': 'Visual Responses in Mice Lacking Critical Components of All Known Retinal Phototransduction Cascades', 'publication_year': 2010, 'publication_date': '2010-11-29', 'ids': {'openalex': 'https://openalex.org/W2046609408', 'doi': 'https://doi.org/10.1371/journal.pone.0015063', 'mag': '2046609408', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21124780', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2993945'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0015063', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0015063&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0015063&type=printable', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5085411623', 'display_name': 'Annette E. Allen', 'orcid': 'https://orcid.org/0000-0003-0214-7076'}, 'institutions': [{'id': 'https://openalex.org/I28407311', 'display_name': 'University of Manchester', 'ror': 'https://ror.org/027m9bs27', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I28407311']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Annette E. Allen', 'raw_affiliation_strings': ['‡Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom'], 'affiliations': [{'raw_affiliation_string': '‡Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom', 'institution_ids': ['https://openalex.org/I28407311']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003879713', 'display_name': 'Morven A. Cameron', 'orcid': 'https://orcid.org/0000-0002-2277-7035'}, 'institutions': [{'id': 'https://openalex.org/I28407311', 'display_name': 'University of Manchester', 'ror': 'https://ror.org/027m9bs27', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I28407311']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Morven A. Cameron', 'raw_affiliation_strings': ['‡Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom'], 'affiliations': [{'raw_affiliation_string': '‡Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom', 'institution_ids': ['https://openalex.org/I28407311']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070509490', 'display_name': 'Timothy M. Brown', 'orcid': 'https://orcid.org/0000-0002-5625-4750'}, 'institutions': [{'id': 'https://openalex.org/I28407311', 'display_name': 'University of Manchester', 'ror': 'https://ror.org/027m9bs27', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I28407311']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Timothy M. Brown', 'raw_affiliation_strings': ['‡Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom'], 'affiliations': [{'raw_affiliation_string': '‡Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom', 'institution_ids': ['https://openalex.org/I28407311']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046739263', 'display_name': 'Anthony Vugler', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Anthony A. Vugler', 'raw_affiliation_strings': ['Department of Ocular Biology and Therapeutics, University College London, Institute of Ophthalmology, London, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Department of Ocular Biology and Therapeutics, University College London, Institute of Ophthalmology, London, United Kingdom', 'institution_ids': ['https://openalex.org/I45129253']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5064699466', 'display_name': 'Robert J. Lucas', 'orcid': 'https://orcid.org/0000-0002-1088-8029'}, 'institutions': [{'id': 'https://openalex.org/I28407311', 'display_name': 'University of Manchester', 'ror': 'https://ror.org/027m9bs27', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I28407311']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Robert J. Lucas', 'raw_affiliation_strings': ['‡Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom'], 'affiliations': [{'raw_affiliation_string': '‡Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom', 'institution_ids': ['https://openalex.org/I28407311']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 1805, 'currency': 'USD', 'value_usd': 1805, 'provenance': 'doaj'}, 'apc_paid': {'value': 1805, 'currency': 'USD', 'value_usd': 1805, 'provenance': 'doaj'}, 'fwci': 1.999, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 63, 'citation_normalized_percentile': {'value': 0.999985, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '5', 'issue': '11', 'first_page': 'e15063', 'last_page': 'e15063'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10691', 'display_name': 'Retinal Development and Disorders', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10691', 'display_name': 'Retinal Development and Disorders', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12236', 'display_name': 'Photoreceptor and optogenetics research', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10077', 'display_name': 'Neuroscience and Neuropharmacology Research', 'score': 0.9981, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/visual-phototransduction', 'display_name': 'Visual phototransduction', 'score': 0.96597445}, {'id': 'https://openalex.org/keywords/transducin', 'display_name': 'Transducin', 'score': 0.94169474}, {'id': 'https://openalex.org/keywords/melanopsin', 'display_name': 'Melanopsin', 'score': 0.8992404}, {'id': 'https://openalex.org/keywords/opsin', 'display_name': 'Opsin', 'score': 0.86810744}, {'id': 'https://openalex.org/keywords/lateral-geniculate-nucleus', 'display_name': 'Lateral geniculate nucleus', 'score': 0.4596145}], 'concepts': [{'id': 'https://openalex.org/C131667965', 'wikidata': 'https://www.wikidata.org/wiki/Q445081', 'display_name': 'Visual phototransduction', 'level': 3, 'score': 0.96597445}, {'id': 'https://openalex.org/C149574991', 'wikidata': 'https://www.wikidata.org/wiki/Q420428', 'display_name': 'Transducin', 'level': 4, 'score': 0.94169474}, {'id': 'https://openalex.org/C3449773', 'wikidata': 'https://www.wikidata.org/wiki/Q92594', 'display_name': 'Melanopsin', 'level': 4, 'score': 0.8992404}, {'id': 'https://openalex.org/C30028475', 'wikidata': 'https://www.wikidata.org/wiki/Q24785022', 'display_name': 'Opsin', 'level': 4, 'score': 0.86810744}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.69915533}, {'id': 'https://openalex.org/C202033177', 'wikidata': 'https://www.wikidata.org/wiki/Q423107', 'display_name': 'Rhodopsin', 'level': 3, 'score': 0.6886124}, {'id': 'https://openalex.org/C2777093970', 'wikidata': 'https://www.wikidata.org/wiki/Q169342', 'display_name': 'Retina', 'level': 2, 'score': 0.6157025}, {'id': 'https://openalex.org/C38137364', 'wikidata': 'https://www.wikidata.org/wiki/Q934475', 'display_name': 'Intrinsically photosensitive retinal ganglion cells', 'level': 4, 'score': 0.5667926}, {'id': 'https://openalex.org/C2780827179', 'wikidata': 'https://www.wikidata.org/wiki/Q422001', 'display_name': 'Retinal', 'level': 2, 'score': 0.54164565}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.51916873}, {'id': 'https://openalex.org/C2776362945', 'wikidata': 'https://www.wikidata.org/wiki/Q719179', 'display_name': 'Lateral geniculate nucleus', 'level': 3, 'score': 0.4596145}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.4432502}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.32716492}, {'id': 'https://openalex.org/C105702510', 'wikidata': 'https://www.wikidata.org/wiki/Q514', 'display_name': 'Anatomy', 'level': 1, 'score': 0.32090175}, {'id': 'https://openalex.org/C189780591', 'wikidata': 'https://www.wikidata.org/wiki/Q7187882', 'display_name': 'Photopigment', 'level': 3, 'score': 0.23981845}, {'id': 'https://openalex.org/C2777624874', 'wikidata': 'https://www.wikidata.org/wiki/Q927337', 'display_name': 'Retinal ganglion cell', 'level': 3, 'score': 0.115626216}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D054815', 'descriptor_name': 'Cyclic Nucleotide-Gated Cation Channels', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D044385', 'descriptor_name': 'GTP-Binding Protein alpha Subunits', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D055537', 'descriptor_name': 'Light Signal Transduction', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D017299', 'descriptor_name': 'Rod Opsins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D015293', 'descriptor_name': 'Transducin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D014793', 'descriptor_name': 'Visual Cortex', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D014796', 'descriptor_name': 'Visual Perception', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000221', 'descriptor_name': 'Adaptation, Ocular', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D000221', 'descriptor_name': 'Adaptation, Ocular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054815', 'descriptor_name': 'Cyclic Nucleotide-Gated Cation Channels', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054815', 'descriptor_name': 'Cyclic Nucleotide-Gated Cation Channels', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D004596', 'descriptor_name': 'Electroretinography', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004963', 'descriptor_name': 'Estrenes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004963', 'descriptor_name': 'Estrenes', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D044385', 'descriptor_name': 'GTP-Binding Protein alpha Subunits', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044385', 'descriptor_name': 'GTP-Binding Protein alpha Subunits', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D005829', 'descriptor_name': 'Geniculate Bodies', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D005829', 'descriptor_name': 'Geniculate Bodies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005829', 'descriptor_name': 'Geniculate Bodies', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D055537', 'descriptor_name': 'Light Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055537', 'descriptor_name': 'Light Signal Transduction', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018345', 'descriptor_name': 'Mice, Knockout', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010726', 'descriptor_name': 'Phosphodiesterase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010726', 'descriptor_name': 'Phosphodiesterase Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011760', 'descriptor_name': 'Pyrrolidinones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011760', 'descriptor_name': 'Pyrrolidinones', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D012160', 'descriptor_name': 'Retina', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D012160', 'descriptor_name': 'Retina', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012160', 'descriptor_name': 'Retina', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017948', 'descriptor_name': 'Retinal Rod Photoreceptor Cells', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D017948', 'descriptor_name': 'Retinal Rod Photoreceptor Cells', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D017948', 'descriptor_name': 'Retinal Rod Photoreceptor Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017299', 'descriptor_name': 'Rod Opsins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D017299', 'descriptor_name': 'Rod Opsins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015293', 'descriptor_name': 'Transducin', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015293', 'descriptor_name': 'Transducin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014793', 'descriptor_name': 'Visual Cortex', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014793', 'descriptor_name': 'Visual Cortex', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D014793', 'descriptor_name': 'Visual Cortex', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014796', 'descriptor_name': 'Visual Perception', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D014796', 'descriptor_name': 'Visual Perception', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 8, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0015063', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0015063&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/8758d3c190d641c7883fa86bc84c5e88', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2993945', 'pdf_url': 'https://europepmc.org/articles/pmc2993945?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.research.manchester.ac.uk/portal/en/publications/visual-responses-in-mice-lacking-critical-components-of-all-known-retinal-phototransduction-cascades(8e857ca9-5e6b-4c78-ac76-a2ecb79de9c4).html', 'pdf_url': 'http://www.plosone.org/article/fetchObjectAttachment.action?uri=info%3Adoi%2F10.1371%2Fjournal.pone.0015063&representation=PDF', 'source': {'id': 'https://openalex.org/S4306400662', 'display_name': 'Research Explorer (The University of Manchester)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I28407311', 'host_organization_name': 'University of Manchester', 'host_organization_lineage': ['https://openalex.org/I28407311'], 'host_organization_lineage_names': ['University of Manchester'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://discovery.ucl.ac.uk/id/eprint/440820/', 'pdf_url': 'https://discovery.ucl.ac.uk/440820/1/440820.pdf', 'source': {'id': 'https://openalex.org/S4306400024', 'display_name': 'UCL Discovery (University College London)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I45129253', 'host_organization_name': 'University College London', 'host_organization_lineage': ['https://openalex.org/I45129253'], 'host_organization_lineage_names': ['University College London'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://discovery.ucl.ac.uk/id/eprint/440820/1/440820.pdf', 'pdf_url': 'https://discovery.ucl.ac.uk/id/eprint/440820/1/440820.pdf', 'source': {'id': 'https://openalex.org/S4306400024', 'display_name': 'UCL Discovery (University College London)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I45129253', 'host_organization_name': 'University College London', 'host_organization_lineage': ['https://openalex.org/I45129253'], 'host_organization_lineage_names': ['University College London'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993945', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/21124780', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0015063', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0015063&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 33, 'referenced_works': ['https://openalex.org/W1508340757', 'https://openalex.org/W1522048223', 'https://openalex.org/W1959436961', 'https://openalex.org/W1964738011', 'https://openalex.org/W1969161729', 'https://openalex.org/W1983875092', 'https://openalex.org/W2005802189', 'https://openalex.org/W2006460329', 'https://openalex.org/W2011919807', 'https://openalex.org/W2012101359', 'https://openalex.org/W2013322636', 'https://openalex.org/W2014028088', 'https://openalex.org/W2027321601', 'https://openalex.org/W2036239753', 'https://openalex.org/W2056792189', 'https://openalex.org/W2056888759', 'https://openalex.org/W2064628894', 'https://openalex.org/W2066482151', 'https://openalex.org/W2075577721', 'https://openalex.org/W2100028025', 'https://openalex.org/W2105050095', 'https://openalex.org/W2113401699', 'https://openalex.org/W2119719550', 'https://openalex.org/W2124063604', 'https://openalex.org/W2129134595', 'https://openalex.org/W2135393774', 'https://openalex.org/W2135816885', 'https://openalex.org/W2149729365', 'https://openalex.org/W2151900188', 'https://openalex.org/W2155577860', 'https://openalex.org/W2157308120', 'https://openalex.org/W2170271291', 'https://openalex.org/W2417032266'], 'related_works': ['https://openalex.org/W3215669069', 'https://openalex.org/W2981841456', 'https://openalex.org/W2165755710', 'https://openalex.org/W2141029861', 'https://openalex.org/W2054544118', 'https://openalex.org/W2046609408', 'https://openalex.org/W2018575922', 'https://openalex.org/W1603853902', 'https://openalex.org/W1142356321', 'https://openalex.org/W1000556642'], 'abstract_inverted_index': {'The': [0, 71, 119], 'mammalian': [1, 191], 'visual': [2, 169, 192], 'system': [3], 'relies': [4], 'upon': [5, 205], 'light': [6, 89, 113, 121], 'detection': [7], 'by': [8, 115, 135], 'outer-retinal': [9], 'rod/cone': [10], 'photoreceptors': [11], 'and': [12, 47, 165], 'melanopsin-expressing': [13], 'retinal': [14, 62], 'ganglion': [15], 'cells.': [16], 'Gnat1(-/-);Cnga3(-/-);Opn4(-/-)': [17], 'mice': [18, 58, 150], 'lack': [19], 'critical': [20], 'elements': [21], 'of': [22, 24, 31, 74, 81, 99, 126, 139, 160, 167, 181], 'each': [23], 'these': [25, 57], 'photoreceptive': [26], 'mechanisms': [27], 'via': [28], 'targeted': [29], 'disruption': [30], 'genes': [32], 'encoding': [33], 'rod': [34, 100, 117, 182, 196, 210], 'α': [35, 141], 'transducin': [36, 142], '(Gnat1);': [37], 'the': [38, 116, 153, 157, 161, 168, 190], 'cone-specific': [39], 'α3': [40], 'cyclic': [41], 'nucleotide': [42], 'gated': [43], 'channel': [44], 'subunit': [45], '(Cnga3);': [46], 'melanopsin': [48], '(Opn4).': [49], 'Although': [50], 'assumed': [51], 'blind,': [52], 'we': [53], 'show': [54], 'here': [55], 'that': [56, 80, 98, 109, 175], 'retain': [59], 'sufficiently': [60], 'widespread': [61, 187], 'photoreception': [63], 'to': [64, 79, 155, 208], 'drive': [65], 'a': [66, 136, 176], 'reproducible': [67], 'flash': [68], 'electroretinogram': [69], '(ERG).': [70], 'threshold': [72], 'sensitivity': [73], 'this': [75], 'ERG': [76], 'is': [77, 86, 95, 133], 'similar': [78], 'cone-based': [82], 'responses,': [83], 'however': [84], 'it': [85, 110], 'lost': [87], 'under': [88], 'adapted': [90], 'conditions.': [91], 'Its': [92], 'spectral': [93], 'efficiency': [94], 'consistent': [96], 'with': [97, 112], 'opsin,': [101], 'but': [102, 132], 'not': [103], 'cone': [104, 140], 'opsins': [105], 'or': [106], 'melanopsin,': [107], 'indicating': [108], 'originates': [111], 'absorption': [114], 'pigment.': [118], 'TKO': [120, 149], 'response': [122], 'survives': [123], 'intravitreal': [124], 'injection': [125], 'U73122': [127], '(a': [128], 'phospholipase': [129], 'C': [130], 'antagonist),': [131], 'inhibited': [134], 'missense': [137], 'mutation': [138], '(Gnat2(cpfl3)),': [143], 'suggesting': [144], 'Gnat2-dependence.': [145], 'Visual': [146], 'responses': [147, 188], 'in': [148, 189, 202], 'extend': [151], 'beyond': [152], 'retina': [154], 'encompass': [156], 'lateral': [158, 162], 'margins': [159], 'geniculate': [163], 'nucleus': [164], 'components': [166], 'cortex.': [170], 'Our': [171], 'data': [172], 'thus': [173], 'suggest': [174], 'Gnat1-independent': [177], 'phototransduction': [178], 'mechanism': [179], 'downstream': [180], 'opsin': [183], 'can': [184], 'support': [185], 'relatively': [186], 'system.': [193], 'This': [194], 'anomalous': [195], 'opsin-based': [197], 'vision': [198], 'should': [199], 'be': [200], 'considered': [201], 'experiments': [203], 'relying': [204], 'Gnat1': [206], 'knockout': [207], 'silence': [209], 'phototransduction.': [211]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2046609408', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 7}], 'updated_date': '2024-12-08T22:05:12.833495', 'created_date': '2016-06-24'}