Metal-catalyzed asymmetric conjugate addition reaction: formation of quaternary stereocenters

Name: Work Video:
Duration: 3 min 30 s
Christine Hawner; Alexandre Alexakis
{'id': 'https://openalex.org/W2046447764', 'doi': 'https://doi.org/10.1039/c0cc02309d', 'title': 'Metal-catalyzed asymmetric conjugate addition reaction: formation of quaternary stereocenters', 'display_name': 'Metal-catalyzed asymmetric conjugate addition reaction: formation of quaternary stereocenters', 'publication_year': 2010, 'publication_date': '2010-01-01', 'ids': {'openalex': 'https://openalex.org/W2046447764', 'doi': 'https://doi.org/10.1039/c0cc02309d', 'mag': '2046447764', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/20734008'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1039/c0cc02309d', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S152760256', 'display_name': 'Chemical Communications', 'issn_l': '1359-7345', 'issn': ['1359-7345', '1364-548X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320556', 'host_organization_name': 'Royal Society of Chemistry', 'host_organization_lineage': ['https://openalex.org/P4310320556'], 'host_organization_lineage_names': ['Royal Society of Chemistry'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5002739386', 'display_name': 'Christine Hawner', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I114457229', 'display_name': 'University of Geneva', 'ror': 'https://ror.org/01swzsf04', 'country_code': 'CH', 'type': 'education', 'lineage': ['https://openalex.org/I114457229']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Christine Hawner', 'raw_affiliation_strings': ['Department of Organic Chemistry University of Geneva Quai Ernest Ansermet 30 CH-1211 Geneva Switzerland'], 'affiliations': [{'raw_affiliation_string': 'Department of Organic Chemistry University of Geneva Quai Ernest Ansermet 30 CH-1211 Geneva Switzerland', 'institution_ids': ['https://openalex.org/I114457229']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5110128565', 'display_name': 'Alexandre Alexakis', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I114457229', 'display_name': 'University of Geneva', 'ror': 'https://ror.org/01swzsf04', 'country_code': 'CH', 'type': 'education', 'lineage': ['https://openalex.org/I114457229']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Alexandre Alexakis', 'raw_affiliation_strings': ['Department of Organic Chemistry University of Geneva Quai Ernest Ansermet 30 CH-1211 Geneva Switzerland'], 'affiliations': [{'raw_affiliation_string': 'Department of Organic Chemistry University of Geneva Quai Ernest Ansermet 30 CH-1211 Geneva Switzerland', 'institution_ids': ['https://openalex.org/I114457229']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 23.429, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 454, 'citation_normalized_percentile': {'value': 0.999956, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '46', 'issue': '39', 'first_page': '7295', 'last_page': '7295'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11549', 'display_name': 'Synthetic Organic Chemistry Methods', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11549', 'display_name': 'Synthetic Organic Chemistry Methods', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T11611', 'display_name': 'Cyclopropane Reaction Mechanisms', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10013', 'display_name': 'Asymmetric Synthesis and Catalysis', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/stereocenter', 'display_name': 'Stereocenter', 'score': 0.95517695}, {'id': 'https://openalex.org/keywords/conjugate', 'display_name': 'Conjugate', 'score': 0.9548842}, {'id': 'https://openalex.org/keywords/quaternary-carbon', 'display_name': 'Quaternary carbon', 'score': 0.64217067}], 'concepts': [{'id': 'https://openalex.org/C134195300', 'wikidata': 'https://www.wikidata.org/wiki/Q902071', 'display_name': 'Stereocenter', 'level': 4, 'score': 0.95517695}, {'id': 'https://openalex.org/C197336794', 'wikidata': 'https://www.wikidata.org/wiki/Q5161150', 'display_name': 'Conjugate', 'level': 2, 'score': 0.9548842}, {'id': 'https://openalex.org/C178907741', 'wikidata': 'https://www.wikidata.org/wiki/Q745930', 'display_name': 'Nucleophile', 'level': 3, 'score': 0.64598686}, {'id': 'https://openalex.org/C2994484720', 'wikidata': 'https://www.wikidata.org/wiki/Q911288', 'display_name': 'Quaternary carbon', 'level': 4, 'score': 0.64217067}, {'id': 'https://openalex.org/C112613896', 'wikidata': 'https://www.wikidata.org/wiki/Q898370', 'display_name': 'Conjugated system', 'level': 3, 'score': 0.5727897}, {'id': 'https://openalex.org/C21951064', 'wikidata': 'https://www.wikidata.org/wiki/Q899212', 'display_name': 'Combinatorial chemistry', 'level': 1, 'score': 0.5610795}, {'id': 'https://openalex.org/C161790260', 'wikidata': 'https://www.wikidata.org/wiki/Q82264', 'display_name': 'Catalysis', 'level': 2, 'score': 0.5436347}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5238416}, {'id': 'https://openalex.org/C160464908', 'wikidata': 'https://www.wikidata.org/wiki/Q26185', 'display_name': 'Quaternary', 'level': 2, 'score': 0.49395543}, {'id': 'https://openalex.org/C544153396', 'wikidata': 'https://www.wikidata.org/wiki/Q11426', 'display_name': 'Metal', 'level': 2, 'score': 0.49341145}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.27582505}, {'id': 'https://openalex.org/C146686406', 'wikidata': 'https://www.wikidata.org/wiki/Q898628', 'display_name': 'Enantioselective synthesis', 'level': 3, 'score': 0.2466703}, {'id': 'https://openalex.org/C33923547', 'wikidata': 'https://www.wikidata.org/wiki/Q395', 'display_name': 'Mathematics', 'level': 0, 'score': 0.093373}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.068807244}, {'id': 'https://openalex.org/C521977710', 'wikidata': 'https://www.wikidata.org/wiki/Q81163', 'display_name': 'Polymer', 'level': 2, 'score': 0.04614517}, {'id': 'https://openalex.org/C134306372', 'wikidata': 'https://www.wikidata.org/wiki/Q7754', 'display_name': 'Mathematical analysis', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C151730666', 'wikidata': 'https://www.wikidata.org/wiki/Q7205', 'display_name': 'Paleontology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D008670', 'descriptor_name': 'Metals', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D002384', 'descriptor_name': 'Catalysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007202', 'descriptor_name': 'Indicators and Reagents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008670', 'descriptor_name': 'Metals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013237', 'descriptor_name': 'Stereoisomerism', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1039/c0cc02309d', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S152760256', 'display_name': 'Chemical Communications', 'issn_l': '1359-7345', 'issn': ['1359-7345', '1364-548X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320556', 'host_organization_name': 'Royal Society of Chemistry', 'host_organization_lineage': ['https://openalex.org/P4310320556'], 'host_organization_lineage_names': ['Royal Society of Chemistry'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/20734008', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 56, 'referenced_works': ['https://openalex.org/W1679066430', 'https://openalex.org/W1989513876', 'https://openalex.org/W1990557769', 'https://openalex.org/W2000880410', 'https://openalex.org/W2005977429', 'https://openalex.org/W2009016169', 'https://openalex.org/W2013663252', 'https://openalex.org/W2015032020', 'https://openalex.org/W2029402467', 'https://openalex.org/W2047335619', 'https://openalex.org/W2048297600', 'https://openalex.org/W2050313929', 'https://openalex.org/W2054256220', 'https://openalex.org/W2056819269', 'https://openalex.org/W2058265091', 'https://openalex.org/W2058338660', 'https://openalex.org/W2059153547', 'https://openalex.org/W2059997435', 'https://openalex.org/W2060588794', 'https://openalex.org/W2062487750', 'https://openalex.org/W2071804528', 'https://openalex.org/W2074204990', 'https://openalex.org/W2078790658', 'https://openalex.org/W2083159984', 'https://openalex.org/W2085372416', 'https://openalex.org/W2085792772', 'https://openalex.org/W2086837089', 'https://openalex.org/W2090142821', 'https://openalex.org/W2099683398', 'https://openalex.org/W2100463946', 'https://openalex.org/W2100960275', 'https://openalex.org/W2107323023', 'https://openalex.org/W2107440998', 'https://openalex.org/W2107935137', 'https://openalex.org/W2110157790', 'https://openalex.org/W2113308907', 'https://openalex.org/W2114882574', 'https://openalex.org/W2117529128', 'https://openalex.org/W2119352066', 'https://openalex.org/W2123469077', 'https://openalex.org/W2124051004', 'https://openalex.org/W2135481611', 'https://openalex.org/W2142565285', 'https://openalex.org/W2143329305', 'https://openalex.org/W2147141808', 'https://openalex.org/W2147588357', 'https://openalex.org/W2148868352', 'https://openalex.org/W2154525274', 'https://openalex.org/W2950696354', 'https://openalex.org/W2951778651', 'https://openalex.org/W2952467613', 'https://openalex.org/W2952789752', 'https://openalex.org/W2952888235', 'https://openalex.org/W2953223798', 'https://openalex.org/W2953375176', 'https://openalex.org/W4211172071'], 'related_works': ['https://openalex.org/W2969885645', 'https://openalex.org/W2952464778', 'https://openalex.org/W2566599193', 'https://openalex.org/W2524806418', 'https://openalex.org/W2508452919', 'https://openalex.org/W2325544077', 'https://openalex.org/W2144758702', 'https://openalex.org/W2144370118', 'https://openalex.org/W2131676582', 'https://openalex.org/W2061430807'], 'abstract_inverted_index': {'All-carbon': [0], 'quaternary': [1, 39, 67], 'stereocenters': [2], 'are': [3, 19, 70], 'ubiquitous': [4], 'motifs': [5], 'in': [6], 'biological': [7], 'products': [8], 'and': [9], 'pharmaceutical': [10], 'agents.': [11], 'However,': [12], 'due': [13], 'to': [14, 29, 37], 'sterical': [15], 'reasons,': [16], 'these': [17], 'centers': [18, 68], 'not': [20], 'always': [21], 'easily': [22], 'accessible.': [23], 'The': [24], 'metal-catalyzed': [25], 'conjugate': [26, 49, 74], 'addition': [27, 53, 75], 'reaction': [28], 'trisubstituted': [30], 'conjugated': [31], 'substrates': [32], 'presents': [33], 'a': [34], 'viable': [35], 'methodology': [36], 'create': [38], 'centers.': [40], 'In': [41], 'this': [42], 'article,': [43], 'different': [44, 64], 'ways': [45], 'of': [46, 66], 'activating': [47], 'the': [48, 63, 73], 'system': [50], 'towards': [51], 'nucleophilic': [52], 'will': [54, 59], 'be': [55, 60], 'described.': [56], 'An': [57], 'overview': [58], 'given': [61], 'on': [62], 'types': [65], 'that': [69], 'accessible': [71], 'through': [72], 'reaction.': [76]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2046447764', 'counts_by_year': [{'year': 2024, 'cited_by_count': 13}, {'year': 2023, 'cited_by_count': 9}, {'year': 2022, 'cited_by_count': 10}, {'year': 2021, 'cited_by_count': 10}, {'year': 2020, 'cited_by_count': 22}, {'year': 2019, 'cited_by_count': 26}, {'year': 2018, 'cited_by_count': 27}, {'year': 2017, 'cited_by_count': 31}, {'year': 2016, 'cited_by_count': 47}, {'year': 2015, 'cited_by_count': 54}, {'year': 2014, 'cited_by_count': 54}, {'year': 2013, 'cited_by_count': 66}, {'year': 2012, 'cited_by_count': 47}], 'updated_date': '2024-12-21T11:09:16.909270', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
