Title: Displacement of tolbutamide, glibenclamide and chlorpropamide from serum albumin by anionic drugs
Abstract: The binding of tolbutamide, chlorproramide and glibenclamide to human and bovine serum albumin has been estimated in the presence of a number of acidic drugs. It is shown that agreement between experimental data and that calculated using the competitive binding equation is very poor. The degree of displacement of tolbutamide and chlorpropamide is much greater than that calculated using the equation while displacement of glibenclamide is much less. These findings suggest that displacement is essentially non-competitive and that glibenclamide is less susceptible to displacement by acidic drugs than tolbutamide or chlorpropamide.
Publication Year: 1976
Publication Date: 1976-05-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 96
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot