Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2045612398', 'doi': 'https://doi.org/10.1083/jcb.200912084', 'title': 'The APC/C recruits cyclin B1–Cdk1–Cks in prometaphase before D box recognition to control mitotic exit', 'display_name': 'The APC/C recruits cyclin B1–Cdk1–Cks in prometaphase before D box recognition to control mitotic exit', 'publication_year': 2010, 'publication_date': '2010-08-23', 'ids': {'openalex': 'https://openalex.org/W2045612398', 'doi': 'https://doi.org/10.1083/jcb.200912084', 'mag': '2045612398', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/20733055', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2928021'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1083/jcb.200912084', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S96410829', 'display_name': 'The Journal of Cell Biology', 'issn_l': '0021-9525', 'issn': ['0021-9525', '1540-8140'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315676', 'host_organization_name': 'Rockefeller University Press', 'host_organization_lineage': ['https://openalex.org/P4310315676'], 'host_organization_lineage_names': ['Rockefeller University Press'], 'type': 'journal'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://doi.org/10.1083/jcb.200912084', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5036838979', 'display_name': 'Wouter van Zon', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2898336195', 'display_name': 'The Netherlands Cancer Institute', 'ror': 'https://ror.org/03xqtf034', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2898336195']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Wouter van Zon', 'raw_affiliation_strings': ['Division of Molecular Biology 1 and 2', 'Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands 1 and 2'], 'affiliations': [{'raw_affiliation_string': 'Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands 1 and 2', 'institution_ids': ['https://openalex.org/I2898336195']}, {'raw_affiliation_string': 'Division of Molecular Biology 1 and 2', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012773044', 'display_name': 'Janneke Ogink', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2898336195', 'display_name': 'The Netherlands Cancer Institute', 'ror': 'https://ror.org/03xqtf034', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2898336195']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Janneke Ogink', 'raw_affiliation_strings': ['Division of Molecular Biology 1 and 2', 'Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands 1 and 2'], 'affiliations': [{'raw_affiliation_string': 'Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands 1 and 2', 'institution_ids': ['https://openalex.org/I2898336195']}, {'raw_affiliation_string': 'Division of Molecular Biology 1 and 2', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011365421', 'display_name': 'Bas ter Riet', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2898336195', 'display_name': 'The Netherlands Cancer Institute', 'ror': 'https://ror.org/03xqtf034', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2898336195']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Bas ter Riet', 'raw_affiliation_strings': ['Division of Molecular Biology 1 and 2', 'Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands 1 and 2'], 'affiliations': [{'raw_affiliation_string': 'Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands 1 and 2', 'institution_ids': ['https://openalex.org/I2898336195']}, {'raw_affiliation_string': 'Division of Molecular Biology 1 and 2', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074565662', 'display_name': 'René H. Medema', 'orcid': 'https://orcid.org/0000-0002-6754-0381'}, 'institutions': [{'id': 'https://openalex.org/I3018483916', 'display_name': 'University Medical Center Utrecht', 'ror': 'https://ror.org/0575yy874', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3018483916']}, {'id': 'https://openalex.org/I2898336195', 'display_name': 'The Netherlands Cancer Institute', 'ror': 'https://ror.org/03xqtf034', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2898336195']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'René H. Medema', 'raw_affiliation_strings': ['Department of Medical Oncology, University Medical Center Utrecht, 3584 CG Utrecht, Netherlands 3', 'Division of Molecular Biology 1 and 2', 'Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands 1 and 2'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Oncology, University Medical Center Utrecht, 3584 CG Utrecht, Netherlands 3', 'institution_ids': ['https://openalex.org/I3018483916']}, {'raw_affiliation_string': 'Division of Molecular Biology 1 and 2', 'institution_ids': []}, {'raw_affiliation_string': 'Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands 1 and 2', 'institution_ids': ['https://openalex.org/I2898336195']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002551113', 'display_name': 'Hein te Riele', 'orcid': 'https://orcid.org/0000-0003-0255-4042'}, 'institutions': [{'id': 'https://openalex.org/I2898336195', 'display_name': 'The Netherlands Cancer Institute', 'ror': 'https://ror.org/03xqtf034', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2898336195']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Hein te Riele', 'raw_affiliation_strings': ['Division of Molecular Biology 1 and 2', 'Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands 1 and 2'], 'affiliations': [{'raw_affiliation_string': 'Division of Molecular Biology 1 and 2', 'institution_ids': []}, {'raw_affiliation_string': 'Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands 1 and 2', 'institution_ids': ['https://openalex.org/I2898336195']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5060499140', 'display_name': 'Rob M.F. Wolthuis', 'orcid': 'https://orcid.org/0000-0002-3109-1588'}, 'institutions': [{'id': 'https://openalex.org/I2898336195', 'display_name': 'The Netherlands Cancer Institute', 'ror': 'https://ror.org/03xqtf034', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2898336195']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Rob M.F. Wolthuis', 'raw_affiliation_strings': ['Division of Molecular Biology 1 and 2', 'Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands 1 and 2'], 'affiliations': [{'raw_affiliation_string': 'Division of Molecular Biology 1 and 2', 'institution_ids': []}, {'raw_affiliation_string': 'Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands 1 and 2', 'institution_ids': ['https://openalex.org/I2898336195']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.637, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 53, 'citation_normalized_percentile': {'value': 0.999874, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '190', 'issue': '4', 'first_page': '587', 'last_page': '602'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10492', 'display_name': 'Regulation and Function of Microtubules in Cell Division', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10492', 'display_name': 'Regulation and Function of Microtubules in Cell Division', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10303', 'display_name': 'Molecular Mechanisms of Photosynthesis and Photoprotection', 'score': 0.9987, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11041', 'display_name': 'Ubiquitin-Proteasome Proteolytic Pathway', 'score': 0.996, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/prometaphase', 'display_name': 'Prometaphase', 'score': 0.8058419}, {'id': 'https://openalex.org/keywords/cdc20', 'display_name': 'CDC20', 'score': 0.6806069}, {'id': 'https://openalex.org/keywords/cyclin-a2', 'display_name': 'Cyclin A2', 'score': 0.6635206}, {'id': 'https://openalex.org/keywords/cyclin-a', 'display_name': 'Cyclin A', 'score': 0.6524579}, {'id': 'https://openalex.org/keywords/anaphase-promoting-complex', 'display_name': 'Anaphase-promoting complex', 'score': 0.6388221}, {'id': 'https://openalex.org/keywords/cyclin-b1', 'display_name': 'Cyclin B1', 'score': 0.6253034}, {'id': 'https://openalex.org/keywords/cyclin-b', 'display_name': 'Cyclin B', 'score': 0.55683684}, {'id': 'https://openalex.org/keywords/cyclin-d', 'display_name': 'Cyclin D', 'score': 0.48569497}, {'id': 'https://openalex.org/keywords/mitotic-checkpoint', 'display_name': 'Mitotic Checkpoint', 'score': 0.476078}], 'concepts': [{'id': 'https://openalex.org/C154202817', 'wikidata': 'https://www.wikidata.org/wiki/Q14763006', 'display_name': 'Prometaphase', 'level': 5, 'score': 0.8058419}, {'id': 'https://openalex.org/C2781125876', 'wikidata': 'https://www.wikidata.org/wiki/Q17859720', 'display_name': 'CDC20', 'level': 5, 'score': 0.6806069}, {'id': 'https://openalex.org/C28179978', 'wikidata': 'https://www.wikidata.org/wiki/Q5198263', 'display_name': 'Cyclin A2', 'level': 5, 'score': 0.6635206}, {'id': 'https://openalex.org/C16438837', 'wikidata': 'https://www.wikidata.org/wiki/Q5198260', 'display_name': 'Cyclin A', 'level': 5, 'score': 0.6524579}, {'id': 'https://openalex.org/C107888121', 'wikidata': 'https://www.wikidata.org/wiki/Q418432', 'display_name': 'Anaphase-promoting complex', 'level': 5, 'score': 0.6388221}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.6268916}, {'id': 'https://openalex.org/C2778437423', 'wikidata': 'https://www.wikidata.org/wiki/Q5198265', 'display_name': 'Cyclin B1', 'level': 5, 'score': 0.6253034}, {'id': 'https://openalex.org/C9743823', 'wikidata': 'https://www.wikidata.org/wiki/Q5198264', 'display_name': 'Cyclin B', 'level': 5, 'score': 0.55683684}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5423118}, {'id': 'https://openalex.org/C54086632', 'wikidata': 'https://www.wikidata.org/wiki/Q5512671', 'display_name': 'G2-M DNA damage checkpoint', 'level': 5, 'score': 0.53264403}, {'id': 'https://openalex.org/C11882975', 'wikidata': 'https://www.wikidata.org/wiki/Q24781041', 'display_name': 'Cyclin D', 'level': 5, 'score': 0.48569497}, {'id': 'https://openalex.org/C124320809', 'wikidata': 'https://www.wikidata.org/wiki/Q46292', 'display_name': 'Cyclin-dependent kinase', 'level': 4, 'score': 0.3342167}, {'id': 'https://openalex.org/C120504264', 'wikidata': 'https://www.wikidata.org/wiki/Q1147372', 'display_name': 'Cyclin-dependent kinase 1', 'level': 4, 'score': 0.3294897}, {'id': 'https://openalex.org/C120089663', 'wikidata': 'https://www.wikidata.org/wiki/Q59250999', 'display_name': 'Cyclin', 'level': 4, 'score': 0.32725814}, {'id': 'https://openalex.org/C105696609', 'wikidata': 'https://www.wikidata.org/wiki/Q1068809', 'display_name': 'Cell cycle checkpoint', 'level': 4, 'score': 0.27174667}, {'id': 'https://openalex.org/C29537977', 'wikidata': 'https://www.wikidata.org/wiki/Q188941', 'display_name': 'Cell cycle', 'level': 3, 'score': 0.1932962}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.13674566}, {'id': 'https://openalex.org/C53420372', 'wikidata': 'https://www.wikidata.org/wiki/Q22299157', 'display_name': 'Anaphase', 'level': 4, 'score': 0.10568255}, {'id': 'https://openalex.org/C11960822', 'wikidata': 'https://www.wikidata.org/wiki/Q242736', 'display_name': 'Phosphorylation', 'level': 2, 'score': 0.08848393}, {'id': 'https://openalex.org/C82495950', 'wikidata': 'https://www.wikidata.org/wiki/Q14911732', 'display_name': 'Cyclin-dependent kinase 2', 'level': 4, 'score': 0.067388624}, {'id': 'https://openalex.org/C97029542', 'wikidata': 'https://www.wikidata.org/wiki/Q281417', 'display_name': 'Protein kinase A', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D016203', 'descriptor_name': 'CDC2 Protein Kinase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D002352', 'descriptor_name': 'Carrier Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D056744', 'descriptor_name': 'Cyclin B1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D018844', 'descriptor_name': 'Cyclin-Dependent Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D008938', 'descriptor_name': 'Mitosis', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D049468', 'descriptor_name': 'Prometaphase', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D043743', 'descriptor_name': 'Ubiquitin-Protein Ligase Complexes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D064173', 'descriptor_name': 'Anaphase-Promoting Complex-Cyclosome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016203', 'descriptor_name': 'CDC2 Protein Kinase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016203', 'descriptor_name': 'CDC2 Protein Kinase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D042846', 'descriptor_name': 'CDC2-CDC28 Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002352', 'descriptor_name': 'Carrier Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002352', 'descriptor_name': 'Carrier Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D064199', 'descriptor_name': 'Cdc20 Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018797', 'descriptor_name': 'Cell Cycle Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018797', 'descriptor_name': 'Cell Cycle Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D018797', 'descriptor_name': 'Cell Cycle Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019925', 'descriptor_name': 'Cyclin A', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019925', 'descriptor_name': 'Cyclin A', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D019925', 'descriptor_name': 'Cyclin A', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D056744', 'descriptor_name': 'Cyclin B1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D056744', 'descriptor_name': 'Cyclin B1', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D018844', 'descriptor_name': 'Cyclin-Dependent Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018844', 'descriptor_name': 'Cyclin-Dependent Kinases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008938', 'descriptor_name': 'Mitosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009363', 'descriptor_name': 'Neoplasm Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009363', 'descriptor_name': 'Neoplasm Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009363', 'descriptor_name': 'Neoplasm Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015739', 'descriptor_name': 'Nocodazole', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015739', 'descriptor_name': 'Nocodazole', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049468', 'descriptor_name': 'Prometaphase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047428', 'descriptor_name': 'Protein Kinase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047428', 'descriptor_name': 'Protein Kinase Inhibitors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011687', 'descriptor_name': 'Purines', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011687', 'descriptor_name': 'Purines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034622', 'descriptor_name': 'RNA Interference', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011993', 'descriptor_name': 'Recombinant Fusion Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011993', 'descriptor_name': 'Recombinant Fusion Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011993', 'descriptor_name': 'Recombinant Fusion Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000077546', 'descriptor_name': 'Roscovitine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D064249', 'descriptor_name': 'Securin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050257', 'descriptor_name': 'Tubulin Modulators', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050257', 'descriptor_name': 'Tubulin Modulators', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D025801', 'descriptor_name': 'Ubiquitin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D025801', 'descriptor_name': 'Ubiquitin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D043743', 'descriptor_name': 'Ubiquitin-Protein Ligase Complexes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D043743', 'descriptor_name': 'Ubiquitin-Protein Ligase Complexes', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1083/jcb.200912084', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S96410829', 'display_name': 'The Journal of Cell Biology', 'issn_l': '0021-9525', 'issn': ['0021-9525', '1540-8140'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315676', 'host_organization_name': 'Rockefeller University Press', 'host_organization_lineage': ['https://openalex.org/P4310315676'], 'host_organization_lineage_names': ['Rockefeller University Press'], 'type': 'journal'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2928021', 'pdf_url': 'https://europepmc.org/articles/pmc2928021?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928021', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/20733055', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1083/jcb.200912084', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S96410829', 'display_name': 'The Journal of Cell Biology', 'issn_l': '0021-9525', 'issn': ['0021-9525', '1540-8140'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315676', 'host_organization_name': 'Rockefeller University Press', 'host_organization_lineage': ['https://openalex.org/P4310315676'], 'host_organization_lineage_names': ['Rockefeller University Press'], 'type': 'journal'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 61, 'referenced_works': ['https://openalex.org/W1483395792', 'https://openalex.org/W163275813', 'https://openalex.org/W1966542401', 'https://openalex.org/W1969616198', 'https://openalex.org/W1971594042', 'https://openalex.org/W1971797131', 'https://openalex.org/W1974310284', 'https://openalex.org/W1979404830', 'https://openalex.org/W1980766960', 'https://openalex.org/W1991007324', 'https://openalex.org/W1994650857', 'https://openalex.org/W1997160811', 'https://openalex.org/W1999074203', 'https://openalex.org/W1999456659', 'https://openalex.org/W2012173473', 'https://openalex.org/W2019439038', 'https://openalex.org/W2020679691', 'https://openalex.org/W2021020196', 'https://openalex.org/W2021489554', 'https://openalex.org/W2022006967', 'https://openalex.org/W2029158215', 'https://openalex.org/W2029875848', 'https://openalex.org/W2034086671', 'https://openalex.org/W2034536654', 'https://openalex.org/W2035764687', 'https://openalex.org/W2037533459', 'https://openalex.org/W2041652145', 'https://openalex.org/W2044570417', 'https://openalex.org/W2045184659', 'https://openalex.org/W2048693359', 'https://openalex.org/W2050120619', 'https://openalex.org/W2058065336', 'https://openalex.org/W2068836864', 'https://openalex.org/W2071607475', 'https://openalex.org/W2074351205', 'https://openalex.org/W2076753965', 'https://openalex.org/W2078611167', 'https://openalex.org/W2090017838', 'https://openalex.org/W2104458086', 'https://openalex.org/W2114480956', 'https://openalex.org/W2114662977', 'https://openalex.org/W2115566490', 'https://openalex.org/W2116864752', 'https://openalex.org/W2117990990', 'https://openalex.org/W2118073418', 'https://openalex.org/W2119963286', 'https://openalex.org/W2120253739', 'https://openalex.org/W2127565681', 'https://openalex.org/W2127895252', 'https://openalex.org/W2128985829', 'https://openalex.org/W2130145624', 'https://openalex.org/W2136810308', 'https://openalex.org/W2139141152', 'https://openalex.org/W2142790777', 'https://openalex.org/W2144863848', 'https://openalex.org/W2147055985', 'https://openalex.org/W2172106590', 'https://openalex.org/W2172169349', 'https://openalex.org/W2404304740', 'https://openalex.org/W65694556', 'https://openalex.org/W73722401'], 'related_works': ['https://openalex.org/W80278414', 'https://openalex.org/W4361822804', 'https://openalex.org/W3033055530', 'https://openalex.org/W2137036313', 'https://openalex.org/W2124639422', 'https://openalex.org/W2100246943', 'https://openalex.org/W2096952537', 'https://openalex.org/W2045612398', 'https://openalex.org/W1998798121', 'https://openalex.org/W1963739916'], 'abstract_inverted_index': {'The': [0], 'ubiquitin': [1], 'ligase': [2], 'anaphase-promoting': [3], 'complex/cyclosome': [4], '(APC/C)': [5], 'is': [6, 27, 62], 'activated': [7], 'at': [8], 'prometaphase': [9, 69], 'by': [10, 29, 87], 'mitotic': [11, 110], 'phosphorylation': [12], 'and': [13, 92, 112, 127, 158], 'binding': [14, 97], 'of': [15, 71, 144, 155], 'its': [16], 'activator,': [17], 'Cdc20.': [18, 52], 'This': [19, 134], 'initiates': [20], 'cyclin': [21, 25, 46, 60, 75, 80, 82, 101, 125, 128, 146, 156], 'A': [22, 126, 157], 'degradation,': [23], 'whereas': [24, 148], 'B1': [26, 47, 76, 83, 102, 129], 'stabilized': [28], 'the': [30, 36, 74, 85, 88, 93, 119, 137, 152], 'spindle': [31, 138], 'checkpoint.': [32], 'Upon': [33], 'checkpoint': [34, 139, 161], 'release,': [35], 'RXXL': [37], 'destruction': [38], 'box': [39, 142], '(D': [40], 'box)': [41], 'was': [42], 'proposed': [43], 'to': [44, 48, 64, 98], 'direct': [45], 'core': [49], 'APC/C': [50, 67, 86, 105, 121], 'or': [51, 73], 'In': [53], 'this': [54], 'study,': [55], 'we': [56], 'report': [57], 'that': [58, 116, 136], 'endogenous': [59], 'B1–Cdk1': [61], 'recruited': [63], 'checkpoint-inhibited,': [65], 'phosphorylated': [66, 120], 'in': [68, 107, 117, 130], 'independently': [70], 'Cdc20': [72, 159], 'D': [77, 141], 'box.': [78], 'Like': [79], 'A,': [81], 'binds': [84], 'Cdk': [89], 'cofactor': [90], 'Cks': [91], 'APC3': [94], 'subunit.': [95], 'Prior': [96], 'APC/CCdc20': [99], 'makes': [100], 'a': [103, 131], 'better': [104], 'substrate': [106], 'metaphase,': [108], 'driving': [109], 'exit': [111], 'cytokinesis.': [113], 'We': [114], 'conclude': [115], 'prometaphase,': [118], 'can': [122], 'recruit': [123], 'both': [124], 'Cks-dependent': [132], 'manner.': [133], 'suggests': [135], 'blocks': [140], 'recognition': [143], 'APC/C-bound': [145], 'B1,': [147], 'distinctive': [149], 'complexes': [150], 'between': [151], 'N': [153], 'terminus': [154], 'evade': [160], 'control.': [162]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2045612398', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 7}, {'year': 2013, 'cited_by_count': 6}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2024-09-09T11:45:56.445386', 'created_date': '2016-06-24'}