Title: Elucidation of the biosynthesis of meroterpenoid yanuthone D in Aspergillus Niger
Abstract: We have elucidated the mode of biosynthesis of the meroterpenoid compound Yanuthone D in Aspergillus niger. We have successfully deleted all cluster genes, and identified a number of intermediates. Structures of the intermediates were solved using a combined approach comprising classical 1D- and 2D-NMR and tandem mass spectrometry (MS/MS). In this study we have confirmed that Yanuthone D is of meroterpenoid origin, and we have identified an unexpected precursor, which has not before been reported for Aspergillus niger.
Publication Year: 2012
Publication Date: 2012-07-01
Language: en
Type: article
Indexed In: ['crossref']
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