Publication Information

{'id': 'https://openalex.org/W2045334963', 'doi': 'https://doi.org/10.1074/jbc.m109.000042', 'title': 'Long Range Communication between Exosites 1 and 2 Modulates Thrombin Function', 'display_name': 'Long Range Communication between Exosites 1 and 2 Modulates Thrombin Function', 'publication_year': 2009, 'publication_date': '2009-07-10', 'ids': {'openalex': 'https://openalex.org/W2045334963', 'doi': 'https://doi.org/10.1074/jbc.m109.000042', 'mag': '2045334963', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/25713406', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4335219'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m109.000042', 'pdf_url': 'http://www.jbc.org/article/S0021925818810377/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S0021925818810377/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5041878311', 'display_name': 'Nicolas S. Petrera', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I98251732', 'display_name': 'McMaster University', 'ror': 'https://ror.org/02fa3aq29', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I98251732']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Nicolas S. Petrera', 'raw_affiliation_strings': ['Department of Medicine, McMaster University, and Henderson Research Center, Hamilton, Ontario L8V 1C3, Canada.'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, McMaster University, and Henderson Research Center, Hamilton, Ontario L8V 1C3, Canada.', 'institution_ids': ['https://openalex.org/I98251732']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065716918', 'display_name': 'Alan R. Stafford', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I98251732', 'display_name': 'McMaster University', 'ror': 'https://ror.org/02fa3aq29', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I98251732']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Alan R. Stafford', 'raw_affiliation_strings': ['From the Departments of Medicine and Biochemistry and Biomedical Sciences, McMaster University, and Henderson Research Center, Hamilton, Ontario L8V 1C3, Canada'], 'affiliations': [{'raw_affiliation_string': 'From the Departments of Medicine and Biochemistry and Biomedical Sciences, McMaster University, and Henderson Research Center, Hamilton, Ontario L8V 1C3, Canada', 'institution_ids': ['https://openalex.org/I98251732']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5082054329', 'display_name': 'Beverly A. Leslie', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I98251732', 'display_name': 'McMaster University', 'ror': 'https://ror.org/02fa3aq29', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I98251732']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Beverly A. Leslie', 'raw_affiliation_strings': ['From the Departments of Medicine and Biochemistry and Biomedical Sciences, McMaster University, and Henderson Research Center, Hamilton, Ontario L8V 1C3, Canada'], 'affiliations': [{'raw_affiliation_string': 'From the Departments of Medicine and Biochemistry and Biomedical Sciences, McMaster University, and Henderson Research Center, Hamilton, Ontario L8V 1C3, Canada', 'institution_ids': ['https://openalex.org/I98251732']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5066029896', 'display_name': 'Colin A. Kretz', 'orcid': 'https://orcid.org/0000-0001-7979-7603'}, 'institutions': [{'id': 'https://openalex.org/I98251732', 'display_name': 'McMaster University', 'ror': 'https://ror.org/02fa3aq29', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I98251732']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Colin A. Kretz', 'raw_affiliation_strings': ['From the Departments of Medicine and Biochemistry and Biomedical Sciences, McMaster University, and Henderson Research Center, Hamilton, Ontario L8V 1C3, Canada'], 'affiliations': [{'raw_affiliation_string': 'From the Departments of Medicine and Biochemistry and Biomedical Sciences, McMaster University, and Henderson Research Center, Hamilton, Ontario L8V 1C3, Canada', 'institution_ids': ['https://openalex.org/I98251732']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006549987', 'display_name': 'James C. Fredenburgh', 'orcid': 'https://orcid.org/0000-0003-1223-0754'}, 'institutions': [{'id': 'https://openalex.org/I98251732', 'display_name': 'McMaster University', 'ror': 'https://ror.org/02fa3aq29', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I98251732']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'James C. Fredenburgh', 'raw_affiliation_strings': ['From the Departments of Medicine and Biochemistry and Biomedical Sciences, McMaster University, and Henderson Research Center, Hamilton, Ontario L8V 1C3, Canada'], 'affiliations': [{'raw_affiliation_string': 'From the Departments of Medicine and Biochemistry and Biomedical Sciences, McMaster University, and Henderson Research Center, Hamilton, Ontario L8V 1C3, Canada', 'institution_ids': ['https://openalex.org/I98251732']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5082464840', 'display_name': 'Jeffrey I. Weitz', 'orcid': 'https://orcid.org/0000-0002-1092-7550'}, 'institutions': [{'id': 'https://openalex.org/I98251732', 'display_name': 'McMaster University', 'ror': 'https://ror.org/02fa3aq29', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I98251732']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Jeffrey I. Weitz', 'raw_affiliation_strings': ['From the Departments of Medicine and Biochemistry and Biomedical Sciences, McMaster University, and Henderson Research Center, Hamilton, Ontario L8V 1C3, Canada'], 'affiliations': [{'raw_affiliation_string': 'From the Departments of Medicine and Biochemistry and Biomedical Sciences, McMaster University, and Henderson Research Center, Hamilton, Ontario L8V 1C3, Canada', 'institution_ids': ['https://openalex.org/I98251732']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 3.389, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 71, 'citation_normalized_percentile': {'value': 0.999842, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '284', 'issue': '38', 'first_page': '25620', 'last_page': '25629'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10881', 'display_name': 'Blood Coagulation and Thrombosis Mechanisms', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10881', 'display_name': 'Blood Coagulation and Thrombosis Mechanisms', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10746', 'display_name': 'Platelet Disorders and Treatments', 'score': 0.9977, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10620', 'display_name': 'Protease and Inhibitor Mechanisms', 'score': 0.9962, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/hirudin', 'display_name': 'Hirudin', 'score': 0.84205246}, {'id': 'https://openalex.org/keywords/aptamer', 'display_name': 'Aptamer', 'score': 0.4986832}], 'concepts': [{'id': 'https://openalex.org/C2778271848', 'wikidata': 'https://www.wikidata.org/wiki/Q386715', 'display_name': 'Hirudin', 'level': 4, 'score': 0.84205246}, {'id': 'https://openalex.org/C2777292125', 'wikidata': 'https://www.wikidata.org/wiki/Q409166', 'display_name': 'Thrombin', 'level': 3, 'score': 0.8159374}, {'id': 'https://openalex.org/C166342909', 'wikidata': 'https://www.wikidata.org/wiki/Q845326', 'display_name': 'Allosteric regulation', 'level': 3, 'score': 0.7733288}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.7603979}, {'id': 'https://openalex.org/C54173615', 'wikidata': 'https://www.wikidata.org/wiki/Q27205', 'display_name': 'Fibrin', 'level': 2, 'score': 0.73292255}, {'id': 'https://openalex.org/C2779036427', 'wikidata': 'https://www.wikidata.org/wiki/Q381899', 'display_name': 'Fibrinogen', 'level': 2, 'score': 0.70113105}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.5689241}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.54919535}, {'id': 'https://openalex.org/C57002609', 'wikidata': 'https://www.wikidata.org/wiki/Q5281999', 'display_name': 'Discovery and development of direct thrombin inhibitors', 'level': 4, 'score': 0.5315661}, {'id': 'https://openalex.org/C128972844', 'wikidata': 'https://www.wikidata.org/wiki/Q418722', 'display_name': 'Aptamer', 'level': 2, 'score': 0.4986832}, {'id': 'https://openalex.org/C2779281246', 'wikidata': 'https://www.wikidata.org/wiki/Q172847', 'display_name': 'Peptide', 'level': 2, 'score': 0.49655086}, {'id': 'https://openalex.org/C107824862', 'wikidata': 'https://www.wikidata.org/wiki/Q616005', 'display_name': 'Binding site', 'level': 2, 'score': 0.48533598}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.20941013}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.18102488}, {'id': 'https://openalex.org/C89560881', 'wikidata': 'https://www.wikidata.org/wiki/Q101026', 'display_name': 'Platelet', 'level': 2, 'score': 0.1280593}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.10418928}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D005337', 'descriptor_name': 'Fibrin', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D005340', 'descriptor_name': 'Fibrinogen', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D013917', 'descriptor_name': 'Thrombin', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D000494', 'descriptor_name': 'Allosteric Regulation', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D000494', 'descriptor_name': 'Allosteric Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005337', 'descriptor_name': 'Fibrin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005337', 'descriptor_name': 'Fibrin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D005340', 'descriptor_name': 'Fibrinogen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005340', 'descriptor_name': 'Fibrinogen', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017434', 'descriptor_name': 'Protein Structure, Tertiary', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D017434', 'descriptor_name': 'Protein Structure, Tertiary', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020349', 'descriptor_name': 'Surface Plasmon Resonance', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013917', 'descriptor_name': 'Thrombin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D013917', 'descriptor_name': 'Thrombin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m109.000042', 'pdf_url': 'http://www.jbc.org/article/S0021925818810377/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2757964', 'pdf_url': 'https://europepmc.org/articles/pmc2757964?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757964', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/19589779', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m109.000042', 'pdf_url': 'http://www.jbc.org/article/S0021925818810377/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 49, 'referenced_works': ['https://openalex.org/W1486898082', 'https://openalex.org/W1491436521', 'https://openalex.org/W1500832609', 'https://openalex.org/W1507466570', 'https://openalex.org/W1515982653', 'https://openalex.org/W1517896461', 'https://openalex.org/W1525549376', 'https://openalex.org/W1531765158', 'https://openalex.org/W1553185560', 'https://openalex.org/W1582785412', 'https://openalex.org/W1603365810', 'https://openalex.org/W1604105761', 'https://openalex.org/W1605419972', 'https://openalex.org/W1972112385', 'https://openalex.org/W1980398280', 'https://openalex.org/W1992989611', 'https://openalex.org/W1997255202', 'https://openalex.org/W1998906394', 'https://openalex.org/W2001854628', 'https://openalex.org/W2003843472', 'https://openalex.org/W2004021726', 'https://openalex.org/W2010020730', 'https://openalex.org/W2011955429', 'https://openalex.org/W2012130949', 'https://openalex.org/W2015367504', 'https://openalex.org/W2028503793', 'https://openalex.org/W2049991016', 'https://openalex.org/W2057952723', 'https://openalex.org/W2062307087', 'https://openalex.org/W2067058572', 'https://openalex.org/W2067327367', 'https://openalex.org/W2068123793', 'https://openalex.org/W2072856207', 'https://openalex.org/W2077182436', 'https://openalex.org/W2077375327', 'https://openalex.org/W2101296091', 'https://openalex.org/W2106733037', 'https://openalex.org/W2109078461', 'https://openalex.org/W2109906659', 'https://openalex.org/W2112629837', 'https://openalex.org/W2151982987', 'https://openalex.org/W2168409771', 'https://openalex.org/W2170567456', 'https://openalex.org/W2410737623', 'https://openalex.org/W2550348382', 'https://openalex.org/W4210663131', 'https://openalex.org/W4211160326', 'https://openalex.org/W4229675254', 'https://openalex.org/W84979909'], 'related_works': ['https://openalex.org/W2412372608', 'https://openalex.org/W2284875578', 'https://openalex.org/W2138849164', 'https://openalex.org/W2088968209', 'https://openalex.org/W2052384028', 'https://openalex.org/W2023523876', 'https://openalex.org/W2013574584', 'https://openalex.org/W1964256982', 'https://openalex.org/W1963822565', 'https://openalex.org/W131863389'], 'abstract_inverted_index': {'Although': [0, 242, 1123, 1555], 'exosites': [1, 227, 243, 469, 488, 553, 568, 1129, 1145, 1585], '1': [2, 48, 191, 228, 244, 290, 433, 470, 489, 554, 602, 831, 1106, 1169, 1218, 1308, 1586, 1775, 2267, 2334, 2608, 3128, 3370, 3447, 3556, 3573, 3637, 4148, 4336], 'and': [3, 11, 13, 72, 131, 152, 229, 245, 253, 255, 314, 373, 394, 471, 490, 520, 542, 555, 576, 666, 688, 786, 850, 859, 866, 959, 965, 1134, 1258, 1379, 1436, 1587, 1721, 1859, 1922, 1961, 1967, 1971, 1985, 2005, 2079, 2106, 2125, 2146, 2253, 2260, 2277, 2321, 2358, 2402, 2411, 2443, 2487, 2535, 2591, 2602, 2632, 2649, 2693, 2710, 2721, 2795, 2847, 2879, 2889, 2910, 2920, 2981, 3070, 3134, 3161, 3168, 3212, 3249, 3364, 3395, 3473, 3495, 3572, 3636, 3661, 3761, 3813, 3859, 3885, 3952, 3983, 3992, 4002, 4031, 4045, 4095, 4197, 4289, 4326, 4353, 4364], '2': [4, 51, 96, 126, 230, 246, 293, 338, 368, 472, 491, 941, 1002, 1109, 1369, 1378, 1510, 1588, 1824, 2907, 2911, 3115, 3250, 3434, 3641, 3838, 3949, 3990, 3993, 4075, 4179], 'regulate': [5, 247], 'thrombin': [6, 42, 100, 116, 135, 148, 157, 177, 213, 240, 248, 284, 342, 358, 377, 390, 399, 419, 455, 482, 493, 514, 549, 738, 822, 931, 961, 1013, 1152, 1385, 1501, 1743, 1760, 1769, 1873, 1894, 1911, 3086, 3105, 3209, 3227, 3932, 4077, 4129, 4142, 4226, 4313, 4393, 4424], 'activity': [7, 249, 3184, 3202, 3933, 4057], 'by': [8, 14, 108, 250, 256, 350, 533, 552, 613, 823, 851, 920, 963, 1006, 1439, 1567, 1592, 1654, 1981, 2142, 2151, 2363, 2382, 2548, 2657, 2808, 2943, 2965, 3007, 3052, 3159, 3173, 3258, 3294, 3323, 3498, 3514, 3550, 3663, 3691, 3693, 3706, 3790, 4062, 4074, 4099, 4375], 'binding': [9, 101, 136, 251, 343, 378, 545, 571, 854, 1211, 1303, 1761, 1874, 1909, 2645, 2821, 3102, 3228, 3619, 4206, 4306, 4323], 'substrates': [10, 252, 573, 614, 828, 1133, 1187, 2103], 'cofactors': [12, 254, 575, 1135], 'allosterically': [15, 257], 'modulating': [16, 258], 'the': [17, 30, 61, 65, 84, 92, 118, 138, 145, 154, 174, 187, 202, 208, 237, 259, 272, 303, 307, 326, 334, 360, 380, 387, 396, 416, 429, 444, 450, 479, 509, 540, 564, 570, 583, 610, 689, 819, 1124, 1128, 1144, 1179, 1223, 1253, 1279, 1302, 1310, 1381, 1484, 1497, 1564, 1568, 1580, 1713, 1731, 1738, 1754, 1766, 1866, 1885, 1891, 1908, 1964, 1982, 1995, 2020, 2024, 2028, 2044, 2244, 2304, 2341, 2490, 2603, 2622, 2635, 2738, 2772, 2780, 2803, 2820, 2828, 2831, 2836, 2843, 2850, 2995, 3010, 3016, 3019, 3032, 3071, 3081, 3095, 3125, 3138, 3155, 3174, 3200, 3205, 3216, 3219, 3265, 3313, 3450, 3476, 3500, 3504, 3592, 3647, 3665, 3671, 3684, 3694, 3699, 3716, 3808, 3862, 3871, 3881, 3928, 4024, 4055, 4064, 4079, 4104, 4117, 4173, 4188, 4218, 4230, 4284, 4303, 4370, 4384, 4388, 4397, 4405], 'active': [18, 260, 565, 584, 611, 1180, 1227, 1498, 1565, 3084, 3093, 3104, 4231], 'site,': [19, 261], 'it': [20, 262, 1570], 'is': [21, 25, 183, 263, 267, 425, 515, 550, 603, 1004, 1130, 1141, 1437, 1511, 1557, 1575, 2827, 2835, 2842, 2849, 4138], 'unclear': [22, 264, 1572], 'whether': [23, 265, 1573, 1903], 'there': [24, 127, 266, 369, 1140, 1556, 1574], 'direct': [26, 268, 1576], 'allosteric': [27, 224, 269, 466, 1149, 1265, 1490, 1561, 1577], 'linkage': [28, 225, 270, 467], 'between': [29, 186, 226, 271, 428, 468, 487, 1579, 1584, 2777, 3375, 4392], 'two': [31, 273], 'exosites.': [32, 274, 1581, 4394], 'To': [33, 82, 275, 324, 1764, 2038, 3079, 3413, 3431, 3941, 4115, 4368, 4395], 'begin': [34, 276], 'to': [35, 98, 102, 137, 172, 236, 277, 340, 344, 379, 414, 478, 548, 606, 609, 829, 1011, 1131, 1167, 1186, 1216, 1221, 1306, 1363, 1388, 1496, 1717, 1724, 1762, 1864, 1875, 1883, 1912, 1999, 2256, 2280, 2330, 2480, 2516, 2587, 2620, 2652, 2749, 2775, 2819, 2870, 2898, 2901, 2924, 2993, 3028, 3106, 3131, 3170, 3214, 3301, 3337, 3417, 3470, 3583, 3591, 3603, 3774, 3807, 3861, 3880, 3890, 3985, 4015, 4217, 4277, 4312, 4328, 4382], 'address': [36, 278], 'this,': [37, 279], 'we': [38, 90, 280, 332, 1729, 1752, 1901, 4126, 4378, 4402], 'first': [39, 281, 4403], 'titrated': [40, 282, 2746, 2832, 4176, 4234], 'a': [41, 129, 283, 371, 927, 1213, 1371, 1503, 1742, 1940, 1974, 2281, 2290, 2296, 2309, 2316, 2481, 2501, 2530, 2681, 2686, 2696, 2784, 2871, 2903, 2915, 2947, 2986, 3056, 3188, 3298, 3326, 3342, 3383, 3440, 3511, 3520, 3538, 3577, 3597, 3607, 3609, 3778, 3891, 3897, 3937, 3944, 3970, 4010, 4036, 4128, 4139, 4195, 4214, 4268, 4292, 4315, 4417], 'variant': [43, 285, 1744, 1976, 4130, 4143], 'fluorescently': [44, 286, 4131, 4227], 'labeled': [45, 287, 1747, 4132, 4228], 'at': [46, 288, 529, 1383, 1988, 2295, 2343, 2350, 2398, 2404, 2416, 2466, 2495, 2542, 2610, 2641, 2677, 2703, 2725, 2883, 2929, 2967, 3074, 3152, 3195, 3382, 3392, 3439, 3537, 3576, 3596, 3801, 3873, 3999, 4006, 4133, 4229], 'exosite': [47, 50, 95, 109, 190, 209, 289, 292, 337, 351, 432, 451, 815, 830, 921, 940, 1168, 1217, 1269, 1307, 1364, 1377, 1509, 1734, 1749, 1774, 1823, 1869, 1904, 1914, 1965, 2647, 3047, 3098, 3319, 3687, 3713, 4120, 4124, 4134, 4147, 4178, 4309, 4319, 4335, 4409], 'with': [49, 115, 178, 214, 291, 357, 420, 456, 536, 582, 1138, 2048, 2243, 2251, 2306, 2505, 2550, 2680, 2747, 3120, 3308, 3369, 3466, 3563, 3768, 3830, 3896, 4144, 4150, 4177, 4235, 4267, 4291, 4341, 4347, 4358, 4423], 'ligands,': [52, 192, 294, 434, 4030], 'HD22': [53, 143, 295, 385, 1962, 2764, 2858, 3144, 3225, 4282], '(a': [54, 194, 296, 436], 'DNA': [55, 195, 297, 437], 'aptamer),': [56, 298], 'γ′-peptide': [57, 299, 2029, 2045, 2590, 2624, 2637, 2758, 2861, 3588, 4183, 4205, 4236, 4278], '(an': [58, 199, 300, 441], 'analog': [59, 200, 301, 442, 2018, 2088], 'of': [60, 64, 67, 87, 94, 120, 147, 156, 176, 201, 205, 212, 239, 302, 306, 309, 329, 336, 362, 389, 398, 418, 443, 447, 454, 481, 495, 512, 546, 572, 821, 826, 1016, 1127, 1151, 1178, 1212, 1225, 1255, 1281, 1304, 1312, 1374, 1483, 1500, 1563, 1712, 1733, 1741, 1756, 1868, 1887, 1893, 1910, 1977, 2019, 2023, 2026, 2043, 2053, 2089, 2092, 2299, 2318, 2356, 2409, 2423, 2485, 2533, 2539, 2582, 2596, 2646, 2662, 2707, 2713, 2718, 2752, 2800, 2830, 2838, 2857, 2873, 2886, 2906, 2917, 2957, 2977, 2997, 3002, 3013, 3018, 3024, 3034, 3041, 3046, 3055, 3092, 3097, 3103, 3127, 3140, 3143, 3164, 3176, 3179, 3203, 3207, 3218, 3224, 3237, 3243, 3260, 3269, 3275, 3284, 3289, 3297, 3306, 3317, 3341, 3386, 3404, 3409, 3428, 3443, 3452, 3475, 3516, 3519, 3541, 3552, 3555, 3566, 3580, 3600, 3658, 3677, 3686, 3701, 3712, 3718, 3720, 3792, 3828, 3867, 3927, 3943, 3973, 3981, 3989, 4028, 4038, 4051, 4058, 4066, 4083, 4103, 4167, 4182, 4191, 4220, 4270, 4286, 4295, 4307, 4324, 4361, 4387, 4399, 4407, 4415, 4419], 'COOH': [62, 203, 304, 445], 'terminus': [63, 204, 305, 446], 'γ′-chain': [66, 308, 2025], 'fibrinogen)': [68, 310], 'or': [69, 123, 180, 197, 311, 365, 422, 439, 574, 1163, 1276, 2377, 2767, 2864, 3267, 3310, 3315, 3332, 3378, 3406, 3459, 3632, 3640, 3679, 3834, 3844, 3965, 4026, 4072, 4081, 4090, 4184, 4279], 'heparin.': [70, 312], 'Concentration-dependent': [71, 313], 'saturable': [73, 132, 315, 374, 4198], 'changes': [74, 316], 'in': [75, 117, 134, 317, 359, 376, 517, 531, 539, 934, 1263, 1491, 1505, 1748, 2051, 2471, 2489, 2593, 2667, 2685, 2728, 2881, 2914, 2955, 3015, 3031, 3124, 3137, 3187, 3264, 3312, 3358, 3373, 3389, 3424, 3449, 3525, 3683, 3698, 3766, 3821, 3870, 3969, 4009, 4018, 4023, 4043, 4078, 4111, 4146, 4194, 4318], 'fluorescence': [76, 318, 1506, 1739, 2740, 2773, 2781, 2845, 4166, 4189, 4285, 4376], 'were': [77, 164, 319, 406, 1881, 1925, 1979, 1997, 2046, 2082, 2109, 2128, 2379, 2413, 2522, 2630, 2638, 2789, 2806, 2868, 2922, 2963, 2979, 3049, 3166, 3291, 3334, 3356, 3367, 3482, 3561, 3644, 3653, 3704, 3772, 3811, 3818, 3851, 3888, 3934, 3947, 3997, 4033, 4041, 4097, 4109, 4332], 'elicited,': [78, 320], 'supporting': [79, 321], 'inter-exosite': [80, 322], 'linkage.': [81, 323], 'explore': [83, 325], 'functional': [85, 327, 4385], 'consequences': [86, 328, 4386], 'this': [88, 330, 1726, 1826], 'phenomenon,': [89, 331], 'evaluated': [91, 333], 'capacity': [93, 335], 'ligands': [97, 339, 547, 1305, 1723, 1736, 1758, 1871, 1889, 1906, 2651, 3100, 3320, 3714, 3930, 4053, 4122, 4311, 4337, 4411], 'inhibit': [99, 341, 2257], 'γA/γA-fibrin,': [103, 345, 3418], 'an': [104, 346, 1172, 1226, 1264, 1913, 2011, 2536, 2704, 2722, 2729, 3349, 3978], 'interaction': [105, 175, 211, 347, 417, 453, 581, 3305], 'mediated': [106, 348, 919], 'solely': [107, 349], '1.': [110, 352, 816, 1750, 4135, 4320], 'When': [111, 353], 'γA/γA-fibrinogen': [112, 179, 354, 421, 1771, 2909, 3244, 3290, 3309, 3405, 3416, 3982], 'was': [113, 128, 170, 355, 370, 412, 1219, 1716, 1746, 1828, 1939, 1954, 2031, 2097, 2117, 2133, 2138, 2149, 2205, 2249, 2313, 2361, 2478, 2527, 2546, 2585, 2605, 2618, 2655, 2675, 2701, 2745, 2896, 2936, 2953, 3005, 3038, 3077, 3109, 3118, 3157, 3185, 3210, 3229, 3253, 3256, 3278, 3321, 3380, 3411, 3422, 3437, 3468, 3508, 3589, 3616, 3689, 3726, 3788, 3877, 4004, 4020, 4060, 4170, 4175, 4209, 4233], 'clotted': [114, 356, 3119], 'presence': [119, 361, 3126, 3139, 3268, 3316, 3451, 3685, 4027, 4082], 'HD22,': [121, 363, 1978, 3455, 3625, 3961, 4089], 'γ′-peptide,': [122, 364, 3458, 3628, 3964], 'prothrombin': [124, 366, 1104, 1107, 1367, 2209, 2332], 'fragment': [125, 367, 699, 701, 1105, 1108, 1215, 1368, 2333], 'dose-dependent': [130, 372, 4196], 'decrease': [133, 375, 1278], 'resultant': [139, 381], 'fibrin': [140, 382, 1389, 1857, 1898, 2961, 3156, 3724, 3804], 'clots.': [141, 161, 383, 403, 1899], 'Furthermore,': [142, 384], 'reduced': [144, 386], 'affinity': [146, 388, 4343], 'for': [149, 221, 391, 463, 579, 856, 932, 1014, 1560, 2002, 2010, 2492, 2607, 2797, 2926, 2971, 2983, 3149, 3446, 3491, 3655, 3798, 3815, 3857, 4204], 'γA/γA-fibrin': [150, 160, 392, 402, 3107, 3311], '6-fold': [151, 393], 'accelerated': [153, 395], 'dissociation': [155, 397, 1895, 2851, 3472], 'from': [158, 400, 1161, 1272, 1896, 1927, 1943, 1948, 1955, 2032, 2084, 2099, 2110, 2118, 2129, 2135, 2140, 2207, 2336, 2340, 2625, 2791, 3009, 3090, 3503, 3670, 3722, 3853], 'preformed': [159, 401, 1897], 'Similar': [162, 404], 'responses': [163, 405], 'obtained': [165, 407, 1926, 2083, 2790], 'when': [166, 408, 1158, 1508, 4225], 'surface': [167, 409, 1110, 1174, 1860], 'plasmon': [168, 410, 703, 1111, 1861], 'resonance': [169, 411, 1112, 1862], 'used': [171, 413, 605, 695, 1005, 1855, 2619, 2954, 3213, 3469, 4379], 'monitor': [173, 415, 3471], 'fibrin.': [181, 423, 1763], 'There': [182, 424], 'bidirectional': [184, 426], 'communication': [185, 427, 486, 4391], 'exosites,': [188, 430, 1569], 'because': [189, 431, 1366], 'HD1': [193, 435, 1959, 2761, 3631, 4325, 4352], 'aptamer)': [196, 438], 'hirudin-(54–65)': [198, 440, 2768, 4327, 4354], 'hirudin),': [206, 448], 'inhibited': [207, 449, 1438], '2-mediated': [210, 452], 'immobilized': [215, 457, 3415, 3509], 'γ′-peptide.': [216, 458], 'These': [217, 459, 523, 567, 4300], 'findings': [218, 460, 4301], 'provide': [219, 461], 'evidence': [220, 462, 1142, 1559], 'long': [222, 464, 4389], 'range': [223, 465, 485, 4390], 'on': [231, 473, 711, 1009, 1170, 1737, 1759, 1872, 1890, 2008, 2144, 2289, 2365, 3101, 3199, 3226, 3715, 3931, 4054, 4412], 'thrombin,': [232, 474, 1139, 1171, 3094, 3204], 'revealing': [233, 475], 'further': [234, 476], 'complexity': [235, 477], 'mechanisms': [238, 480], 'regulation.': [241, 483], 'Long': [484], 'modulates': [492], 'function.Journal': [494], 'Biological': [496], 'ChemistryVol.': [497], '290Issue': [498], '8PreviewVOLUME': [499], '284': [500], '(2009)': [501], 'PAGES': [502], '25620–25629': [503], 'Full-Text': [504], 'PDF': [505, 634, 660, 682, 758, 782, 846, 886, 910, 981, 1038, 1068, 1247, 1297, 1332, 1352, 1404, 1430, 1459, 1477, 1535, 1551, 1611, 1631, 1674, 1704, 1792, 1816, 1848, 2174, 2198, 2236, 2439, 2459, 2574, 3749, 3919, 4255], 'Open': [506], 'Access': [507], 'As': [508, 2946, 3606, 4321], 'central': [510], 'effector': [511], 'hemostasis,': [513], 'engaged': [516], 'procoagulant,': [518], 'anticoagulant,': [519], 'fibrinolytic': [521], 'processes.': [522], 'seemingly': [524], 'contrasting': [525], 'roles': [526], 'are': [527, 558, 918, 1165, 1360, 1489], 'regulated,': [528], 'least': [530], 'part,': [532], "thrombin's": [534], 'interactions': [535], 'other': [537, 827, 935], 'factors': [538, 640], 'blood': [541], 'vasculature.': [543], 'The': [544, 1210, 1710, 2247, 2354, 2407, 2644, 3000, 3022, 3222, 3273, 3304, 3675, 3710, 3865, 3925, 4013, 4049, 4165, 4202], 'promoted': [551], '2,': [556, 922], 'which': [557, 923, 1251, 1384], 'positively': [559], 'charged': [560], 'domains': [561], 'that': [562, 736, 929, 1143, 1486, 1745, 1768, 3083, 3681, 4119, 4305, 4345, 4373, 4421], 'flank': [563], 'site.': [566], 'facilitate': [569], 'align': [577], 'them': [578], 'optimal': [580], 'site': [585, 612, 1181, 1228, 1499, 1566, 4232], '(1Lane': [586], 'D.A.': [587, 619, 1777], 'Philippou': [588], 'H.': [589], 'Huntington': [590, 798], 'J.A.': [591, 773, 799, 1025], 'Blood.': [592], '2005;': [593], '106:': [594], '2605-2612Crossref': [595], 'PubMed': [596, 635, 661, 683, 730, 759, 783, 808, 847, 887, 911, 954, 982, 996, 1039, 1069, 1096, 1205, 1248, 1298, 1333, 1353, 1405, 1431, 1460, 1478, 1536, 1552, 1612, 1632, 1647, 1675, 1705, 1793, 1817, 1849, 2068, 2175, 2199, 2237, 2440, 2460, 2575, 3750, 3920, 4160, 4256], 'Scopus': [597, 636, 662, 684, 731, 809, 912, 955, 997, 1040, 1070, 1097, 1206, 1354, 1432, 1461, 1537, 1633, 1648, 1676, 1706, 1794, 1818, 1850, 2069, 2176, 2200, 2238, 2576, 3751, 3921, 4161, 4257], '(274)': [598], 'Google': [599, 638, 664, 686, 733, 760, 784, 811, 848, 888, 914, 957, 983, 999, 1042, 1072, 1099, 1208, 1249, 1299, 1334, 1356, 1406, 1434, 1463, 1479, 1539, 1553, 1613, 1635, 1650, 1678, 1708, 1796, 1820, 1852, 2071, 2178, 2202, 2240, 2441, 2461, 2578, 3753, 3923, 4163, 4259], 'Scholar).': [600, 734, 915, 1000, 1100, 1209, 1300, 1357, 1480, 1554, 1709, 1853, 2072, 2203, 2579, 3754, 3924, 4164], 'Exosite': [601, 1001], 'predominantly': [604], 'gain': [607], 'access': [608, 825, 1185], 'such': [615], 'as': [616, 926, 1148, 2153, 2217, 2553, 2941, 3232, 3280, 3728, 4035, 4172], 'fibrinogen': [617, 1277, 1387, 2141, 3037, 3938, 4420], '(2Meh': [618, 1776], 'Siebenlist': [620, 1778], 'K.R.': [621, 1779], 'Mosesson': [622, 1780], 'M.W.': [623, 1781], 'J.': [624, 650, 672, 743, 750, 774, 838, 878, 897, 900, 973, 1028, 1058, 1232, 1239, 1289, 1324, 1342, 1396, 1420, 1449, 1469, 1525, 1543, 1598, 1603, 1621, 1664, 1694, 1782, 1806, 1838, 2062, 2164, 2188, 2226, 2431, 2451, 2564, 3739, 3909, 4245], 'Biol.': [625, 651, 673, 751, 775, 839, 879, 901, 974, 1029, 1059, 1092, 1240, 1290, 1325, 1343, 1397, 1421, 1450, 1470, 1526, 1544, 1604, 1622, 1665, 1695, 1783, 1807, 1839, 2165, 2189, 2227, 2432, 2452, 2565, 3740, 3910, 4246], 'Chem.': [626, 652, 674, 752, 776, 840, 880, 902, 975, 1030, 1060, 1241, 1291, 1326, 1344, 1398, 1422, 1451, 1471, 1527, 1545, 1605, 1623, 1666, 1696, 1784, 1808, 1840, 2166, 2190, 2228, 2433, 2453, 2566, 3741, 3911, 4247], '1996;': [627, 675, 1785], '271:': [628, 676, 1786], '23121-23125Abstract': [629, 1787], 'Full': [630, 632, 656, 658, 678, 680, 756, 780, 844, 884, 906, 908, 979, 1034, 1036, 1064, 1066, 1245, 1295, 1330, 1348, 1350, 1402, 1426, 1428, 1455, 1457, 1475, 1531, 1533, 1549, 1609, 1627, 1629, 1670, 1672, 1700, 1702, 1788, 1790, 1812, 1814, 1844, 1846, 2170, 2172, 2194, 2196, 2232, 2234, 2437, 2457, 2570, 2572, 3745, 3747, 3915, 3917, 4251, 4253], 'Text': [631, 633, 657, 659, 679, 681, 757, 781, 845, 885, 907, 909, 980, 1035, 1037, 1065, 1067, 1246, 1296, 1331, 1349, 1351, 1403, 1427, 1429, 1456, 1458, 1476, 1532, 1534, 1550, 1610, 1628, 1630, 1671, 1673, 1701, 1703, 1789, 1791, 1813, 1815, 1845, 1847, 2171, 2173, 2195, 2197, 2233, 2235, 2438, 2458, 2571, 2573, 3746, 3748, 3916, 3918, 4252, 4254], '(117)': [637, 1795], 'Scholar),': [639, 687, 761, 785, 812, 1250, 1651, 1821, 2462, 4260], 'V': [641], '(3Myles': [642], 'T.': [643, 718, 871, 988], 'Yun': [644], 'T.H.': [645], 'Hall': [646, 1047], 'S.W.': [647, 1048], 'Leung': [648], 'L.L.': [649], '2001;': [653, 727, 1061], '276:': [654, 1062], '25143-25149Abstract': [655], '(81)': [663], 'Scholar)': [665, 849, 958, 1435, 2241, 2442], 'VIII': [667], '(4Esmon': [668], 'C.T.': [669, 747, 797, 833, 1236, 1321, 1468, 1602, 2428], 'Lollar': [670], 'P.': [671], '13882-13887Abstract': [677], '(102)': [685, 732], 'protease-activated': [690, 1101], 'receptors': [691], '(PARs)': [692], '2The': [693], 'abbreviations': [694], 'are:': [696], 'PARprotease-activated': [697], 'receptor5-IAF5-iodoacetamidofluoresceinF1prothrombin': [698], '1F2prothrombin': [700], '2SPRsurface': [702], 'resonanceHBSHepes-buffered': [704], 'salineFPRckd-Phe-Pro-Arg': [705], 'chloromethyl': [706, 708, 1116, 1119], 'ketoneYPRckd-Tyr-Pro-Arg': [707], 'ketoneRUresponse': [709], 'unit(s).': [710, 1122], 'platelets': [712, 1010], '(5Ayala': [713], 'Y.M.': [714], 'Cantwell': [715], 'A.M.': [716], 'Rose': [717], 'Bush': [719], 'L.A.': [720, 1081, 2448], 'Arosio': [721], 'D.': [722], 'Di': [723, 1082, 1194], 'Cera': [724, 1083, 1195], 'E.': [725, 1046, 1084, 1196], 'Proteins.': [726], '45:': [728, 1645], '107-116Crossref': [729], 'Effectors': [735], 'modulate': [737, 1907, 4123], 'activity,': [739], 'including': [740], 'thrombomodulin': [741, 1214], '(6Ye': [742], 'Liu': [744], 'L.W.': [745, 1317, 1596], 'Esmon': [746, 796, 834, 1233, 1235, 1320, 1467, 1601, 2427], 'Johnson': [748, 1237, 1599], 'A.E.': [749, 1238, 1600], '1992;': [753, 1546], '267:': [754, 1547], '11023-11028Abstract': [755], 'hirudin': [762, 2095], '(7Naski': [763], 'M.C.': [764, 1642], 'Fenton': [765], '2nd,': [766], 'J.W.': [767], 'Maraganore': [768], 'J.M.': [769], 'Olson': [770, 1443, 1658], 'S.T.': [771, 970, 1444, 1659], 'Shafer': [772], '1990;': [777, 881], '265:': [778, 882], '13484-13489Abstract': [779], 'heparin': [787, 938, 966, 1273, 2755, 4186, 4263], 'cofactor': [788, 967, 1274], 'II': [789, 968, 1275], '(8Baglin': [790], 'T.P.': [791], 'Carrell': [792], 'R.W.': [793], 'Church': [794], 'F.C.': [795], 'Proc.': [800, 946, 1197], 'Natl.': [801, 947, 1198], 'Acad.': [802, 948, 1199], 'Sci.': [803, 949, 1200], 'U.S.A.': [804, 950, 1201], '2002;': [805, 1031, 1452, 1667], '99:': [806], '11079-11084Crossref': [807], '(186)': [810], 'also': [813, 1003, 1146, 3108, 4331], 'utilize': [814], 'Thrombomodulin': [817], 'alters': [818, 1309], 'specificity': [820], 'hindering': [824], '(9Esmon': [832], 'N.L.': [835, 1234], 'Harris': [836], 'K.W.': [837], '1982;': [841, 976], '257:': [842, 977], '7944-7947Abstract': [843], 'providing': [852, 1184], 'new': [853], 'sites': [855], 'protein': [857, 1256, 1282, 2094], 'C': [858, 1257, 1283], 'thrombin-activable': [860, 1259], 'fibrinolysis': [861, 1260], 'inhibitor,': [862], 'thereby': [863, 1183], 'promoting': [864], 'anticoagulant': [865], 'antifibrinolytic': [867], 'pathways,': [868], 'respectively': [869], '(10Hayashi': [870], 'Zushi': [872], 'M.': [873, 893, 895, 899, 2059], 'Yamamoto': [874], 'S.': [875, 1050, 1681, 1683], 'Suzuki': [876], 'K.': [877], '20156-20159Abstract': [883], 'Scholar,': [889, 984, 1043, 1073, 1335, 1407, 1464, 1540, 1614, 1636, 1679, 1797, 2179], '11Wang': [890], 'W.': [891], 'Nagashima': [892], 'Schneider': [894], 'Morser': [896], 'Nesheim': [898], '2000;': [903], '275:': [904], '22942-22947Abstract': [905], '(90)': [913], 'Fewer': [916], 'processes': [917], 'serves': [924], 'largely': [925], 'tether': [928], 'anchors': [930], 'participation': [933], 'reactions.': [936], 'Thus,': [937, 4351], 'binds': [939, 1376, 1770], '(12Sheehan': [942], 'J.P.': [943], 'Sadler': [944], 'J.E.': [945], '1994;': [951], '91:': [952], '5518-5522Crossref': [953], '(184)': [956], 'catalyzes': [960], 'inhibition': [962], 'antithrombin': [964, 1440], '(13Olson': [969], 'Shore': [971], 'J.D.': [972], '14891-14895Abstract': [978], '14Yamagishi': [985], 'R.': [986, 1052, 1057, 1693], 'Koide': [987], 'Sakuragawa': [989], 'N.': [990, 1688], 'FEBS': [991], 'Lett.': [992], '1987;': [993], '225:': [994], '109-112Crossref': [995], '(9)': [998], 'glycoprotein': [1007], '1bα': [1008], 'localize': [1012], 'activation': [1015, 1262, 1284, 2210], 'PARs': [1017], '(15Baglia': [1018], 'F.A.': [1019], 'Badellino': [1020], 'K.O.': [1021], 'Li': [1022], 'C.Q.': [1023], 'Lopez': [1024], 'Walsh': [1026], 'P.N.': [1027], '277:': [1032, 1453, 1668], '1662-1668Abstract': [1033], '(87)': [1041, 1207], '16De': [1044], 'Candia': [1045], 'Rutella': [1049, 1682], 'Landolfi': [1051], 'Andrews': [1053], 'R.K.': [1054], 'De': [1055, 1684, 1691], 'Cristofaro': [1056, 1692], '4692-4698Abstract': [1063], '(203)': [1071], '17Berny': [1074], 'M.A.': [1075], 'White': [1076], 'T.C.': [1077], 'Tucker': [1078], 'E.I.': [1079], 'Bush-Pelc': [1080], 'Gruber': [1085], 'A.': [1086, 1415, 1520], 'McCarty': [1087], 'O.J.': [1088], 'Arterioscler.': [1089], 'Thromb.': [1090, 2063], 'Vasc.': [1091], '2008;': [1093, 1202, 1697, 2191, 2567, 3742, 3912], '28:': [1094], '329-334Crossref': [1095], '(37)': [1098], 'receptor': [1102], '5-iodoacetamidofluorescein': [1103], 'Hepes-buffered': [1113], 'saline': [1114, 2669], 'd-Phe-Pro-Arg': [1115], 'ketone': [1117, 1120, 2074, 2077, 2081, 2255], 'd-Tyr-Pro-Arg': [1118], 'response': [1121, 3401], 'prevailing': [1125], 'role': [1126], 'bring': [1132], 'into': [1136], 'proximity': [1137], 'serve': [1147], 'regulators': [1150], 'activity.': [1153], 'Crystallographic': [1154], 'studies': [1155, 1880], 'reveal': [1156], 'that,': [1157], 'peptides': [1159, 1271], 'derived': [1160], 'PAR1': [1162], 'PAR3': [1164], 'bound': [1166, 1495, 3003, 3026, 3042, 3220, 3277, 3285, 3682, 4264, 4290, 4338, 4355], 'obstructing': [1173], 'loop': [1175, 3781], 'moves': [1176], 'out': [1177], 'pocket,': [1182], '(18Gandhi': [1188], 'P.S.': [1189], 'Chen': [1190], 'Z.': [1191], 'Mathews': [1192], 'F.S.': [1193], '105:': [1203], '1832-1837Crossref': [1204], 'shown': [1220], 'alter': [1222], 'environment': [1224], 'fluorescent': [1229, 1493], 'probe': [1230], '(19Ye': [1231], '1991;': [1242, 1292, 1327, 1606, 2454], '266:': [1243, 1293, 1328, 1607, 2455], '23016-23021Abstract': [1244], 'accelerates': [1252], 'rate': [1254, 1280, 1382, 1892, 2298, 3385, 3442, 3540, 3579, 3599, 3717], 'inhibitor': [1261], 'fashion.': [1266], 'In': [1267, 1481, 1877, 4275], 'contrast,': [1268], '1-binding': [1270], '(20Hortin': [1285], 'G.L.': [1286], 'Trimpe': [1287], 'B.L.': [1288], '6866-6871Abstract': [1294], 'Additionally,': [1301], 'rates': [1311], 'chromogenic': [1313, 3171, 4056], 'substrate': [1314], 'hydrolysis': [1315, 4065], '(21Liu': [1316], 'Vu': [1318], 'T.K.': [1319], 'Coughlin': [1322], 'S.R.': [1323], '16977-16980Abstract': [1329], '22Sakharov': [1336], 'D.V.': [1337], 'Plow': [1338], 'E.F.': [1339], 'Rijken': [1340], 'D.C.': [1341], '1997;': [1345, 1624, 2229], '272:': [1346, 1625, 2230], '14477-14482Abstract': [1347], '(208)': [1355], 'Allosteric': [1358], 'effects': [1359, 1583, 3926], 'not': [1361, 1653], 'limited': [1362], '1,': [1365, 4125], '(F2),': [1370], 'cleavage': [1372], 'product': [1373], 'prothrombin,': [1375], 'decreases': [1380], 'converts': [1386], '(23Jakubowski': [1390], 'H.V.': [1391], 'Kline': [1392], 'M.D.': [1393], 'Owen': [1394], 'W.G.': [1395, 2426], '1986;': [1399], '261:': [1400], '3876-3882Abstract': [1401], '24Liaw': [1408], 'P.C.': [1409, 1514], 'Fredenburgh': [1410, 1515, 1802, 1834, 2160, 4241], 'J.C.': [1411, 1516, 1616, 1803, 1835, 2161, 2181, 2221, 2557, 3732, 3902, 4242], 'Stafford': [1412, 1517, 1617, 1800, 1832, 2158, 2182, 2222, 2558, 3733, 3903, 4239], 'A.R.': [1413, 1518, 1618, 1801, 1833, 2159, 2183, 2223, 2559, 3734, 3904, 4240], 'Tulinsky': [1414, 1519], 'Austin': [1416, 1521], 'R.C.': [1417, 1522], 'Weitz': [1418, 1523, 1619, 1804, 1836, 2162, 2186, 2224, 2562, 3737, 3907, 4243], 'J.I.': [1419, 1524, 1620, 1805, 1837, 2163, 2187, 2225, 2563, 3738, 3908, 4244], '1998;': [1423, 1528], '273:': [1424, 1529], '8932-8939Abstract': [1425, 1530], '(30)': [1433, 1538], '(25Verhamme': [1441, 1656], 'I.M.': [1442, 1657], 'Tollefsen': [1445, 1660], 'D.M.': [1446, 1661], 'Bock': [1447, 1662], 'P.E.': [1448, 1542, 1663], '6788-6798Abstract': [1454, 1669], '(69)': [1462, 1677], '26Walker': [1465], 'F.J.': [1466], '1979;': [1472], '254:': [1473], '5618-5622Abstract': [1474], 'support': [1482, 4302], 'concept': [1485, 4304], 'these': [1487, 1757, 2933, 4308], 'alterations': [1488], 'origin,': [1492], 'probes': [1494], 'undergo': [1502], 'change': [1504, 4317], 'intensity': [1507, 1740, 2786, 4190], 'occupied': [1512], '(24Liaw': [1513], '27Bock': [1541], '14974-14981Abstract': [1548], 'good': [1558], 'regulation': [1562], 'remains': [1571], 'connection': [1578], 'Reciprocal': [1582], 'have': [1589], 'been': [1590], 'observed': [1591, 4346], 'some': [1593], 'investigators': [1594], '(28Liu': [1595], 'Ye': [1597], '23633-23636Abstract': [1608], '29Fredenburgh': [1615], '25493-25499Abstract': [1626, 2231], '(96)': [1634, 2239], '30Sabo': [1637], 'T.M.': [1638], 'Farrell': [1639, 2060], 'D.H.': [1640, 2061], 'Maurer': [1641], 'Biochemistry.': [1643, 4156], '2006;': [1644], '7434-7445Crossref': [1646], '(33)': [1649], 'but': [1652, 2242], 'others': [1655], '31Lancellotti': [1680], 'Filippis': [1685], 'V.': [1686], 'Pozzi': [1687], 'Rocca': [1689], 'B.': [1690, 2353], '283:': [1698, 2192, 2568, 3743, 3913], '30193-30204Abstract': [1699], '(36)': [1707], 'aim': [1711], 'current': [1714], 'study': [1715], 'use': [1718], 'different': [1719], 'techniques': [1720], 'additional': [1722, 2012, 4380, 4408], 'resolve': [1725], 'controversy.': [1727], 'First,': [1728], 'examined': [1730, 1753, 3935, 4404], 'effect': [1732, 1755, 1886, 3096, 3223, 3711, 4406], '2-directed': [1735, 1870, 1915, 1968, 2650, 3099, 4121, 4310, 4410], 'Next,': [1751], 'exploit': [1765], 'observation': [1767], 'exclusively': [1772], 'via': [1773], '32Pospisil': [1798], 'C.H.': [1799, 1831, 2157, 4238], '2003;': [1809, 1841, 2065, 2167, 4248], '278:': [1810, 1842, 2168, 4249], '21584-21591Abstract': [1811, 1843, 2169, 4250], '(64)': [1819, 1851, 2177, 4258], 'leaving': [1822], 'accessible,': [1825], 'subpopulation': [1827], 'isolated': [1829, 2139, 2206], '(32Pospisil': [1830, 2156, 4237], 'We': [1854], 'intact': [1856, 3723], 'clots': [1858, 2962, 3725, 3805, 3850], '(SPR)': [1863], 'examine': [1865, 1884, 4383], 'influence': [1867, 4050], 'γA/γA-fibrin.': [1876], 'addition,': [1878], 'diffusion': [1879, 3719], 'performed': [1882, 2314, 4042, 4110], 'exosite-directed': [1888, 3659, 3929, 4029, 4052], 'Finally,': [1900], 'explored': [1902], '1-directed': [1905], 'ligand.': [1916], 'Human': [1917], 'α-thrombin,': [1918], 'γ-thrombin,': [1919], 'plasminogen-free': [1920], 'fibrinogen,': [1921, 2027], 'factor': [1923, 2261, 3764], 'XIII': [1924, 3765], 'Enzyme': [1928], 'Research': [1929, 2214], 'Laboratories,': [1930, 2215], 'Inc.': [1931], '(South': [1932], 'Bend,': [1933], 'IN),': [1934], 'whereas': [1935, 2114, 2347, 4261], 'Quick': [1936, 2464, 4136], 'I-thrombin': [1937, 2465, 2525, 2654, 2666, 2744, 4137, 4169, 4193, 4208, 4266, 4288, 4330, 4340, 4357], '(R67C)': [1938], 'generous': [1941], 'gift': [1942], 'Ruth': [1944], 'Ann': [1945], 'Henrickson.': [1946], 'Batroxobin': [1947, 3130], 'Bothrops': [1949], 'atrox': [1950], 'moojeni': [1951], 'snake': [1952], 'venom': [1953], 'Pentapharm': [1956], '(Switzerland).': [1957], 'Oligonucleotides': [1958], '(5′-GGTTGGTGTGGTTGG-3′)': [1960], '(5′-AGTCCGTGGTAGGGCAGGTTGGGGTGACT-3′),': [1963], '1-': [1966, 2648, 2748], 'aptamers,': [1969], 'respectively,': [1970, 2263, 3398, 3995], 'HD23': [1972], '(5′-AGTCCGTAAAGCAGGTTAAAATGACT-3′),': [1973], 'scrambled': [1975], 'synthesized': [1980], 'Molecular': [1983], 'Biology': [1984], 'Biotechnology': [1986], 'Institute': [1987], 'McMaster': [1989], 'University': [1990], '(Hamilton,': [1991], 'Canada).': [1992], 'Before': [1993], 'use,': [1994], 'aptamers': [1996], 'heated': [1998], '95': [2000], '°C': [2001, 2679], '10': [2003, 2013, 2392, 2687, 2719, 2939, 2972, 3526, 3569, 3756, 4084, 4087, 4091], 'min': [2004, 2494, 2928, 3151, 3448, 3800], 'then': [2006, 2278, 3050, 3230, 3292, 3496, 3819], 'cooled': [2007], 'ice': [2009], 'min.': [2014, 2973, 3430], 'A': [2015, 2086, 2320, 2613, 2893, 3235, 3463], '20-amino': [2016], 'acid': [2017], 'COOH-terminal': [2021], 'portion': [2022], '(H-Val-Arg-Pro-Glu-His-Pro-Ala-Glu-Thr-Glu-Tyr(PO3H2)-Asp-Ser-Leu-Tyr(PO3H2)-Pro-Glu-Asp-Asp-Leu-OH),': [2030], 'Bachem': [2033, 2100], 'AG': [2034], '(San': [2035], 'Diego,': [2036], 'CA).': [2037], 'enhance': [2039], 'stability,': [2040], 'Tyr': [2041], 'residues': [2042, 2090], 'modified': [2047], 'phosphate': [2049, 2270, 2474], 'groups': [2050, 2055, 3549], 'place': [2052, 2956], 'sulfate': [2054], '(33Lovely': [2056], 'R.S.': [2057], 'Moaddel': [2058], 'Haemost.': [2064], '1:': [2066], '124-131Crossref': [2067], '(77)': [2070], 'd-Phe-Pro-Arg-chloromethyl': [2073], '(FPRck),': [2075], 'd-Tyr-Pro-Arg-chloromethyl': [2076], '(YPRck)': [2078], 'dansyl-Glu-Gly-Arg-chloromethyl': [2080, 2254], 'Calbiochem.': [2085], 'peptide': [2087], '54–65': [2091], 'leech': [2093], '(hirudin-(54–65))': [2096], 'purchased': [2098, 2134], 'AG.': [2101], 'Chromogenic': [2102, 3183], 'H-d-Phe-Pip-Arg-p-nitroanilide': [2104], '(S2238)': [2105], 'pyro-Glu-Pro-Arg-pNA-HCl': [2107], '(S2366)': [2108], 'Chromogenix': [2111], '(Milano,': [2112], 'Italy),': [2113], 'tosyl-Gly-Pro-Arg-p-nitroaniline': [2115, 4069], 'acetate': [2116, 3390], 'Aniara': [2119], '(Mason,': [2120], 'OH).': [2121], 'Unfractionated': [2122], 'heparin,': [2123, 4281], 'streptavidin,': [2124], 'biotinaminohexanoic': [2126, 2583], 'acid-3-sulfoester': [2127, 2584], 'Sigma-Aldrich.': [2130], '5-Iodoacetamidofluorescein': [2131], '(5-IAF)': [2132], 'Invitrogen.': [2136], 'γA/γA-Fibrinogen': [2137, 3111, 3331, 3377], 'fractionation': [2143], 'DEAE-Sepharose,': [2145], 'its': [2147], 'integrity': [2148, 2355], 'assessed': [2150, 2362, 2656], 'SDS-PAGE': [2152, 2364], 'previously': [2154, 2218, 2554, 3729, 4224], 'described': [2155, 2219, 2555, 3233, 3281, 3730], '34Fredenburgh': [2180], 'Leslie': [2184, 2560, 3735, 3905], 'B.A.': [2185, 2561, 3736, 3906], '2470-2477Abstract': [2193, 2569, 3744, 3914], '(53)': [2201, 2577, 3752, 3922], 'F2': [2204, 2338, 2357, 2378, 2412, 2865, 3968], 'human': [2208], 'byproduct': [2211], 'fraction': [2212, 3023, 3274, 3676, 3866], '(Enzyme': [2213], 'Inc.)': [2216], '(29Fredenburgh': [2220], 'following': [2245], 'modifications.': [2246], 'material': [2248], 'treated': [2250], 'FPRck': [2252], 'residual': [2258], 'α-thrombin': [2259, 2880, 3123, 3263, 3421, 3951, 4059, 4348], 'Xa,': [2262], 'dialyzed': [2264, 2390], 'overnight': [2265], 'against': [2266, 2391], 'mm': [2268, 2323, 2393, 2396, 2507, 2512, 2690, 2912, 3116, 3251, 3527, 3570], 'sodium': [2269, 3528], '(NaPi)': [2271], 'buffer,': [2272, 2325, 2475, 3855], 'pH': [2273, 2326, 2399, 2476, 2509, 2600, 3393, 3396, 3530], '6.9': [2274, 2327], '(buffer': [2275, 2328], 'A),': [2276], 'applied': [2279], '5-ml': [2282], 'hydroxyapatite': [2283], '(CHT-II)': [2284], 'Econo-Pac': [2285], 'Cartridge': [2286], 'column': [2287, 2305, 2342, 2503, 2615], '(Bio-Rad)': [2288], 'Bio-Rad': [2291], 'Biologic': [2292], 'Duoflow': [2293], 'system': [2294], 'flow': [2297, 3339, 3365, 3384, 3441, 3477, 3535, 3539, 3559, 3578, 3598, 3611, 3648, 3673], '3': [2300], 'ml/min.': [2301], 'After': [2302, 2498, 2737, 2959, 3147, 3544, 3796, 3976], 'washing': [2303], 'buffer': [2307, 2319, 2345, 2352, 3391, 3835], 'A,': [2308], 'stepwise': [2310], 'elution': [2311], 'protocol': [2312], 'using': [2315, 2419, 2529, 2695, 2811, 2985, 3059, 3325, 3348, 3484, 3936], 'mixture': [2317], '500': [2322, 3604], 'NaPi': [2324], 'B),': [2329], 'separate': [2331, 2621, 3338, 3610], '(F1)': [2335], 'F2.': [2337, 3462], 'eluted': [2339, 2349], '16%': [2344], 'B,': [2346], 'F1': [2348, 2359, 2376, 2410], '100%': [2351], 'preparations': [2360], '4–15%': [2366], 'polyacrylamide': [2367], 'gels': [2368], '(Ready-Gel,': [2369], 'Bio-Rad)': [2370], 'under': [2371], 'reducing': [2372], 'conditions.': [2373], 'Fractions': [2374], 'containing': [2375, 2634, 2670, 2877, 3114, 3240, 3360, 3568, 3613, 3622, 3777, 3825, 3836], 'pooled,': [2380], 'concentrated': [2381], 'speed': [2383], 'vacuum': [2384], '(Allegra': [2385], '6R': [2386], 'Centrifuge,': [2387], 'Beckman': [2388], 'Coulter),': [2389], 'Hepes-NaOH,': [2394], '150': [2395, 2511], 'NaCl': [2397, 2513, 3372, 3575], '7.4': [2400], '(HBS),': [2401], 'stored': [2403], '−80': [2405], '°C.': [2406, 2497, 2612, 2931], 'concentrations': [2408, 2856, 2885, 3142, 3242, 3988], 'determined': [2414, 2528, 2942, 3211, 3279, 3483, 3654, 3669, 3697, 4021, 4061, 4098, 4223], 'spectrophotometrically': [2415, 2640], '280': [2417, 2543], 'nm': [2418, 2664, 2709, 2715, 2727, 2888, 3122, 3262, 3420, 3763, 3794, 3950, 4008, 4076, 4297], 'extinction': [2420, 2537], 'coefficients': [2421], '(ml/mg/cm)': [2422], '1.01': [2424], '(35Owen': [2425], 'Jackson': [2429], 'C.M.': [2430], '1974;': [2434], '249:': [2435], '594-605Abstract': [2436], '1.1': [2444], '(36Church': [2445], 'W.R.': [2446], 'Ouellette': [2447], 'Messier': [2449], 'T.L.': [2450], '8384-8391Abstract': [2456], 'respectively.': [2463, 2892, 4367], '0.40': [2467], 'mg/ml': [2468, 3522], '(150': [2469], 'μl)': [2470], '0.2': [2472], 'm': [2473, 2598, 3371, 3557, 3574, 3839], '7.5,': [2477], 'added': [2479, 2586, 2869, 2897, 3773, 3948], '15-fold': [2482], 'molar': [2483], 'excess': [2484], '5-IAF': [2486], 'incubated': [2488, 2606, 3998], 'dark': [2491], '45': [2493, 2927, 3150, 3799], '23': [2496, 2611, 2678, 2930, 3153, 3802, 4000], 'passage': [2499], 'over': [2500, 3532, 3646], 'PD-10': [2502, 2614], 'equilibrated': [2504], '20': [2506, 2887, 3247, 3270, 3387, 3444, 3601, 3771, 3833, 3845, 3974], 'Tris-HCl,': [2508], '7.4,': [2510], '(Tris-buffered': [2514], 'saline)': [2515], 'remove': [2517], 'unreacted': [2518], '5-IAF,': [2519], '0.5-ml': [2520, 2628], 'fractions': [2521, 2629], 'collected.': [2523], '5-IAF-Quick': [2524, 2653, 2665, 2743, 2839, 4168, 4192, 4207, 4265, 4287, 4329, 4339, 4356], 'concentration': [2526, 2805, 2829, 2837, 2905, 2996, 3045, 3206, 3217, 3288, 3494, 3657], 'molecular': [2531], 'weight': [2532], '37,000': [2534], 'coefficient': [2538], '1.8': [2540], 'ml/mg/cm': [2541], 'nm.': [2544, 2643, 3197, 4274], 'α-Thrombin': [2545], 'radiolabeled': [2547], 'reaction': [2549], '125I-labeled': [2551], 'YPRck': [2552], '(34Fredenburgh': [2556, 3731, 3901], 'One': [2580], 'milligram': [2581], '0.5': [2588, 2594], 'mg': [2589], 'dissolved': [2592], 'ml': [2595, 3827], '0.1': [2597], 'NaPi,': [2599], '8,': [2601], 'solution': [2604, 2895, 3524, 3567], 'h': [2609], '(Amersham': [2616, 3329], 'Biosciences)': [2617], 'biotinylated': [2623, 2636], 'unincorporated': [2626], 'biotin.': [2627], 'collected,': [2631], 'samples': [2633, 2921], 'identified': [2639], '214': [2642], 'fluorescence.': [2658], 'An': [2659], '800-μl': [2660], 'aliquot': [2661, 3980], '50': [2663, 3581], 'Tris-buffered': [2668], '0.2%': [2671], 'polyethylene': [2672], 'glycol': [2673], '8000': [2674], 'maintained': [2676], 'circulating': [2682], 'water': [2683], 'bath': [2684], '×': [2688, 2969], '4': [2689, 2949], 'quartz': [2691], 'cuvette': [2692], 'stirred': [2694], 'micro': [2697], 'stir': [2698], 'bar.': [2699], 'Fluorescence': [2700], 'monitored': [2702, 4005, 4171], 'excitation': [2705], 'wavelength': [2706, 2712], '492': [2708], 'emission': [2711, 2723], '532': [2714], '(slit': [2716], 'widths': [2717], 'nm)': [2720], 'filter': [2724], '515': [2726], 'LS': [2730], '50B': [2731], 'luminescence': [2732], 'spectrometer': [2733], '(PerkinElmer': [2734], 'Life': [2735], 'Sciences).': [2736], 'baseline': [2739], '(Io)': [2741], 'stabilized,': [2742], '10-μl': [2750], 'aliquots': [2751, 2976, 3163, 3621], 'either': [2753, 3837], 'unfractionated': [2754, 4185, 4262, 4280], '(1': [2756, 2762, 2765], 'mg/ml),': [2757], '(200': [2759], 'μm),': [2760, 2860, 2863, 3246], 'mm),': [2763, 2766, 2770], '(1.27': [2769], 'allowing': [2771], 'signal': [2774, 2782], 'stabilize': [2776], 'additions.': [2778], 'Once': [2779], 'reached': [2783], 'plateau,': [2785], 'values': [2787, 3481, 3502, 3652, 3668, 3696, 4032, 4360], '(I)': [2788], 'time': [2792, 3875, 3886, 4014], 'drive': [2793], 'profiles': [2794], 'corrected': [2796, 3497, 3662], 'dilution.': [2798], 'Plots': [2799, 3040, 3283], 'I/Io': [2801], 'versus': [2802, 3044, 3287], 'titrant': [2804], 'analyzed': [2807, 3051, 3231, 3293, 3705], 'nonlinear': [2809, 3707, 4100], 'regression': [2810, 3054, 3296, 3708, 4101], 'Table': [2812, 3060], 'Curve': [2813, 3061], '(Jandel': [2814, 3062], 'Scientific,': [2815, 3063, 3784], 'San': [2816, 3067], 'Rafael,': [2817], 'CA)': [2818, 3194], 'equation': [2822], '(Equation': [2823], '1),': [2824], 'where': [2825], 'L': [2826], 'ligand,': [2833], 'Qo': [2834], 'I-thrombin,': [2840], 'α': [2841], 'maximal': [2844], 'change,': [2846], 'Kd': [2848, 4203, 4219, 4269, 4293, 4359], 'constant.': [2852], 'll0=1+α2(1+Kd+LQ0−(1+Kd+LQ0)2−4LQ0)(Eq.': [2853], '1)': [2854], 'Varying': [2855], '(0–20': [2859], '(0–50': [2862], '(0–75': [2866], 'μm)': [2867, 3113], 'series': [2872, 3236], '1.5-ml': [2874], 'microcentrifuge': [2875, 3238, 3775], 'tubes': [2876, 3035, 3239, 3776, 3824], '125I-YPR-α-thrombin': [2878, 3004, 3014, 3025, 3030, 3043, 3276, 3286, 3721, 3868], 'HBS': [2882, 3359, 3374, 3467, 3767, 3829], 'final': [2884, 2904, 3987], '5': [2890, 3261, 3542, 3826, 3841, 4362], 'nm,': [2891], 'stock': [2894], 'each': [2899, 3492, 3656, 3874], 'tube': [2900], 'achieve': [2902], 'μm': [2908, 2950, 3181, 3271, 3435, 3454, 3457, 3461, 3624, 3627, 3630, 3634, 3638, 3642, 3757, 3842, 3846, 3954, 3957, 3960, 3963, 3967, 3991, 4068, 4085, 4088, 4092, 4222, 4363], 'CaCl2': [2913, 3117, 3252, 3984], 'volume': [2916, 3972], '100': [2918, 3419, 3564, 3793], 'μl,': [2919], 'allowed': [2923], 'clot': [2925, 3872], 'Under': [2932], 'conditions': [2934], 'clotting': [2935, 3136, 3939, 4414], 'complete': [2937], 'within': [2938], 'min,': [2940], 'turbidometric': [2944], 'analysis.': [2945, 3709], 'control,': [2948, 3608], 'bovine': [2951], 'albumin': [2952, 3020], 'γA/γA-fibrinogen.': [2958], 'vortexing,': [2960], 'pelleted': [2964, 3158], 'centrifugation': [2966], '14,000': [2968], 'g': [2970], 'Duplicate': [2974], '20-μl': [2975, 3162], 'supernatant': [2978, 3017, 3165], 'removed': [2980, 3167, 3812, 3852], 'counted': [2982, 3814, 3856], 'radioactivity': [2984], 'gamma': [2987], 'counter': [2988], '(1272': [2989], 'Clinigamma,': [2990], 'LKB': [2991], 'Wallace)': [2992], 'determine': [2994, 3302], 'unbound': [2998], '125I-YPR-α-thrombin.': [2999], 'amount': [3001, 3012, 3883], 'calculated': [3006, 3690, 3878], 'subtraction': [3008], 'total': [3011, 3029, 3971], 'controls.': [3021], 'relative': [3027, 3879], 'supernatants': [3033], 'without': [3036], 'calculated.': [3039], 'competitor': [3048], 'non-linear': [3053, 3295], 'rectangular': [3057, 3299], 'hyperbola': [3058, 3300], 'Systat': [3064], 'Software': [3065, 3487], 'Inc.,': [3066], 'Jose': [3068], 'CA),': [3069], 'Kiobs': [3072], '(concentration': [3073], 'half-maximal': [3075, 4016], 'response)': [3076], 'determined.': [3078], 'exclude': [3080], 'possibility': [3082, 4118], 'site-blocked': [3085], 'has': [3087], 'properties': [3088], 'distinct': [3089], 'those': [3091], 'examined.': [3110, 4333], '(5': [3112], '25': [3121], 'unit/ml': [3129], 'ensure': [3132], 'rapid': [3133], 'consistent': [3135], 'varying': [3141, 3241], '(0–5': [3145], 'μm).': [3146], 'incubation': [3148, 3797], '°C,': [3154, 3803, 4001], 'centrifugation,': [3160], 'subjected': [3169], 'assay': [3172], 'addition': [3175, 3259, 3791], '80': [3177], 'μl': [3178, 3518, 3554, 3565], '200': [3180], 'S2238.': [3182], 'read': [3186], 'SpectraMAX': [3189], 'platereader': [3190], '(Molecular': [3191], 'Devices,': [3192], 'Sunnyvale,': [3193], '405': [3196, 4007], 'Based': [3198], 'specific': [3201], 'free': [3208], 'calculate': [3215], 'fraction.': [3221], 'above.': [3234, 3282], '(0–12.5': [3245], 'nm125I-YPR-α-thrombin,': [3248, 3760], 'prepared.': [3254], 'Clotting': [3255, 3787], 'initiated': [3257, 3789], 'absence': [3266, 3314, 3700, 4025, 4080], 'HD22.': [3272, 3847], 'Kd.': [3303], 'FPR-α-thrombin': [3307, 3436, 3639, 3678], 'various': [3318], 'quantified': [3322], 'SPR': [3324, 3354], 'BIAcore': [3327], '1000': [3328], 'Biosciences).': [3330], 'ovalbumin': [3333, 3379, 3410, 3505], 'covalently': [3335], 'linked': [3336], 'cells': [3340, 3366, 3536, 3560], 'carboxymethylated': [3343], 'dextran': [3344], '(CM-5)': [3345], 'biosensor': [3346], 'chip': [3347, 3513, 3595], 'amine': [3350], 'coupling': [3351], 'kit.': [3352], 'All': [3353, 4107], 'procedures': [3355], 'done': [3357], '0.005%': [3361, 3769, 3831], 'Tween': [3362, 3770, 3832], '20,': [3363], 'regenerated': [3368], 'runs.': [3376], 'injected': [3381, 3423, 3438, 3645], 'μl/min': [3388, 3445, 3582, 3602], '5.5': [3394], '4.0,': [3397], 'until': [3399], '10,000': [3400], 'units': [3402], '(RU)': [3403], '5,500': [3407], 'RU': [3408, 3480, 3501, 3651, 3667, 3695], 'adsorbed.': [3412], 'convert': [3414], 'three': [3425, 4047, 4113], 'successive': [3426], 'runs': [3427], '60': [3429], 'measure': [3432], 'binding,': [3433], '0–20': [3453, 3623, 3629, 3633, 3959], '0–50': [3456, 3626, 3962], '0–100': [3460], '1-min': [3464], 'wash': [3465], 'regeneration': [3474], 'cell.': [3478, 3674], 'Peak': [3479, 3650], 'Scrubber2': [3485], '(BioLogic': [3486], 'Co.,': [3488], 'Campbell,': [3489], 'Australia)': [3490], 'ligand': [3493, 3660, 3688], 'subtracting': [3499, 3664], 'control.': [3506], 'Streptavidin': [3507], 'onto': [3510], 'CM-5': [3512, 3594], 'injection': [3515, 3551], '40': [3517, 3553], '0.4': [3521], 'streptavidin': [3523, 3615], 'acetate,': [3529, 4070], '4.5,': [3531], 'all': [3533], 'four': [3534], 'μl/min.': [3543], 'neutralizing': [3545], 'any': [3546], 'remaining': [3547, 3869], 'reactive': [3548], 'ethanolamine,': [3558], 'washed': [3562], 'NaOH': [3571], 'minimize': [3584], 'nonspecific': [3585], 'binding.': [3586], 'Biotinylated': [3587], 'adsorbed': [3590], 'streptavidin-modified': [3593], 'RU.': [3605], 'cell': [3612], 'only': [3614], 'used.': [3617], 'For': [3618], 'studies,': [3620, 4401], 'hirudin-(54–65),': [3635, 3958], 'γ-thrombin': [3643, 3680], 'cells.': [3649], 'peak': [3666], 'blank': [3672], 'dividing': [3692], 'competitor.': [3702], 'Data': [3703], 'measured': [3727], 'Briefly,': [3755], 'γA/γA-fibrinogen,': [3758, 4416], '17': [3759], '15': [3762], 'plastic': [3779, 3809], 'inoculation': [3780], '(Bac-Loop,': [3782], 'Thermo-Fisher': [3783], 'Waltham,': [3785], 'MA).': [3786], 'α-thrombin.': [3795], 'attached': [3806], 'loops': [3810], 'radioactivity.': [3816], 'Clots': [3817], 'placed': [3820], '50-ml': [3822], 'conical': [3823], 'NaCl,': [3840], 'HD1,': [3843, 3955, 4086], 'At': [3848], 'intervals,': [3849], 'bathing': [3854], 'radioactivity,': [3858], 'returned': [3860], 'respective': [3863], 'tubes.': [3864], 'point': [3876, 3900], 'initial': [3882], 'bound,': [3884], 'courses': [3887], 'fit': [3889], 'two-phase': [3892], 'exponential': [3893], 'decay': [3894], 'curve': [3895], 'zero': [3898], 'end': [3899], 'assay.': [3940], 'wells': [3942], '96-well': [3945], 'plate': [3946, 4011], '0–1': [3953, 3956], '0–80': [3966], 'μl.': [3975], 'adding': [3977], '80-μl': [3979], 'yield': [3986], 'mm,': [3994], 'plates': [3996], 'turbidity': [4003, 4019], 'reader.': [4012], 'increase': [4017], 'both': [4022], 'plotted': [4034], 'function': [4037], 'time.': [4039], 'Experiments': [4040], 'duplicate': [4044, 4112], 'repeated': [4046], 'times.': [4048, 4114], 'monitoring': [4063], '0–500': [4067], 'S2238,': [4071], 'S2366': [4073], 'hirudin-(54–65).': [4093], 'Km': [4094], 'kcat': [4096], 'analysis': [4102], 'Michaelis-Menten': [4105], 'equation.': [4106], 'experiments': [4108], 're-examine': [4116], 'utilized': [4127], 'naturally': [4140], 'occurring': [4141], 'Arg-67': [4145], 'replaced': [4149], 'Cys': [4151], '(37Henriksen': [4152], 'R.A.': [4153], 'Mann': [4154], 'K.G.': [4155], '1988;': [4157], '27:': [4158], '9160-9165Crossref': [4159], '(41)': [4162], 'sample': [4174], 'ligands.': [4180], 'Addition': [4181], 'decreased': [4187], 'manner': [4199], '(Fig.': [4200, 4298], '1).': [4201, 4299], '2.5': [4210], '±': [4211, 4272], '0.6': [4212], 'μm,': [4213, 4366], 'value': [4215, 4294], 'similar': [4216], '2.2': [4221], '530': [4271], '58': [4273], 'contrast': [4276], 'increased': [4283], '38': [4296], 'elicits': [4314], 'conformational': [4316], 'controls,': [4322], 'Both': [4334], 'lower': [4342], 'than': [4344], '(not': [4349], 'shown).': [4350], '10.8': [4365], 'extend': [4369], 'investigation': [4371], 'beyond': [4372], 'achieved': [4374], 'measurements,': [4377], 'methods': [4381], 'verify': [4396], 'results': [4398], 'previous': [4400], 'thrombin-mediated': [4413], 'form': [4418], 'interacts': [4422], 'exclusiv': [4425]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2045334963', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 7}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 9}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 8}], 'updated_date': '2024-12-24T14:18:04.589204', 'created_date': '2016-06-24'}