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'4-Quinolones': [57], 'mainly': [58], 'modify': [59], 'activity': [61, 191], 'topoisomerase': [63, 72], 'II': [64], 'gyrase,': [67, 148], 'but': [68, 212], 'also': [69, 105], 'that': [70], 'I': [73], 'IV.': [75], 'Any': [76], 'damage': [77], 'to': [78, 139, 167], 'genome': [81], 'will': [82], 'induce': [83], 'a': [84, 133, 140, 156, 168, 183, 200, 205, 214], 'stress': [85], 'response': [86], 'which': [87, 218], 'consists': [88], 'in': [89, 186], 'SOS': [91], 'response,': [92], 'chaperonin': [93], 'synthesis': [94, 103], 'generation': [97], 'oxygen': [99], 'free': [100], 'radicals.': [101], 'Peptidoglycan': [102], 'modified,': [106], 'as': [107, 182, 199], 'shown': [108], 'by': [109], 'inhibition': [111], 'PBP(3)': [113], 'activity.': [114], 'Mechanism': [115], 'involves': [118], 'mutations': [119, 149, 165, 174], 'gyrA': [121, 125], 'gyrB': [123, 151], 'genes.': [124], 'Mutations': [126], 'chromosome': [129], 'responsible': [131, 154, 176], 'for': [132, 155, 177], 'high': [134, 169], 'level': [135, 158, 170], 'due': [138], 'modification': [141], 'A': [144], 'subunit': [145], 'gene': [152], 'low': [157], 'resistance;': [160], 'combination': [162], 'both': [164], 'leads': [166], 'resistance.': [172], 'Other': [173], 'increasing': [178], 'MIC,': [180], 'such': [181], 'norA': [184], 'mutation': [185], 'S.': [187], 'aureus.': [188], 'antibacterial': [190], 'various': [194], 'different': [197], 'and,': [198], 'result,': [201], 'there': [202], 'not': [204], 'single': [206], 'resistance,': [211], 'rather': [213], 'common': [215], 'trunk': [216], 'additional': [219], 'mechanisms': [220], 'grafted.': [222]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2045309777', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 5}], 'updated_date': '2024-09-03T18:30:54.250047', 'created_date': '2016-06-24'}