Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2045160978', 'doi': 'https://doi.org/10.1074/jbc.m113.507996', 'title': 'Protein Phosphatase 2A Is Regulated by Protein Kinase Cα (PKCα)-dependent Phosphorylation of Its Targeting Subunit B56α at Ser41', 'display_name': 'Protein Phosphatase 2A Is Regulated by Protein Kinase Cα (PKCα)-dependent Phosphorylation of Its Targeting Subunit B56α at Ser41', 'publication_year': 2013, 'publication_date': '2013-11-14', 'ids': {'openalex': 'https://openalex.org/W2045160978', 'doi': 'https://doi.org/10.1074/jbc.m113.507996', 'mag': '2045160978', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/24225947', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3879541'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m113.507996', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://doi.org/10.1074/jbc.m113.507996', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5020433840', 'display_name': 'Uwe Kirchhefer', 'orcid': 'https://orcid.org/0000-0002-2838-2579'}, 'institutions': [{'id': 'https://openalex.org/I4210103666', 'display_name': 'University Hospital Münster', 'ror': 'https://ror.org/01856cw59', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210103666']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Uwe Kirchhefer', 'raw_affiliation_strings': ['Institut für Pharmakologie und Toxikologie, Universitätsklinikum Münster, 48149 Münster, Germany'], 'affiliations': [{'raw_affiliation_string': 'Institut für Pharmakologie und Toxikologie, Universitätsklinikum Münster, 48149 Münster, Germany', 'institution_ids': ['https://openalex.org/I4210103666']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5082896177', 'display_name': 'Alexander Heinick', 'orcid': 'https://orcid.org/0000-0002-3770-105X'}, 'institutions': [{'id': 'https://openalex.org/I4210103666', 'display_name': 'University Hospital Münster', 'ror': 'https://ror.org/01856cw59', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210103666']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Alexander Heinick', 'raw_affiliation_strings': ['Institut für Pharmakologie und Toxikologie, Universitätsklinikum Münster, 48149 Münster, Germany'], 'affiliations': [{'raw_affiliation_string': 'Institut für Pharmakologie und Toxikologie, Universitätsklinikum Münster, 48149 Münster, Germany', 'institution_ids': ['https://openalex.org/I4210103666']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027096741', 'display_name': 'Simone König', 'orcid': 'https://orcid.org/0000-0003-0672-7246'}, 'institutions': [{'id': 'https://openalex.org/I22465464', 'display_name': 'University of Münster', 'ror': 'https://ror.org/00pd74e08', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I22465464']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Simone König', 'raw_affiliation_strings': ['Integrierte Funktionelle Genomik, Interdisziplinäres Zentrum für Klinische Forschung, Westfälische Wilhelms-Universität, 48149 Münster, Germany'], 'affiliations': [{'raw_affiliation_string': 'Integrierte Funktionelle Genomik, Interdisziplinäres Zentrum für Klinische Forschung, Westfälische Wilhelms-Universität, 48149 Münster, Germany', 'institution_ids': ['https://openalex.org/I22465464']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077511199', 'display_name': 'Torsten Nygaard Kristensen', 'orcid': 'https://orcid.org/0000-0001-6204-8753'}, 'institutions': [{'id': 'https://openalex.org/I204337017', 'display_name': 'Aarhus University', 'ror': 'https://ror.org/01aj84f44', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I204337017']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Torsten Kristensen', 'raw_affiliation_strings': ['Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus, Denmark'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus, Denmark', 'institution_ids': ['https://openalex.org/I204337017']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102788740', 'display_name': 'Frank U. Müller', 'orcid': 'https://orcid.org/0000-0002-4896-2511'}, 'institutions': [{'id': 'https://openalex.org/I4210103666', 'display_name': 'University Hospital Münster', 'ror': 'https://ror.org/01856cw59', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210103666']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Frank U. Müller', 'raw_affiliation_strings': ['Institut für Pharmakologie und Toxikologie, Universitätsklinikum Münster, 48149 Münster, Germany'], 'affiliations': [{'raw_affiliation_string': 'Institut für Pharmakologie und Toxikologie, Universitätsklinikum Münster, 48149 Münster, Germany', 'institution_ids': ['https://openalex.org/I4210103666']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050999371', 'display_name': 'Matthias D. Seidl', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210103666', 'display_name': 'University Hospital Münster', 'ror': 'https://ror.org/01856cw59', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210103666']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Matthias D. Seidl', 'raw_affiliation_strings': ['Institut für Pharmakologie und Toxikologie, Universitätsklinikum Münster, 48149 Münster, Germany'], 'affiliations': [{'raw_affiliation_string': 'Institut für Pharmakologie und Toxikologie, Universitätsklinikum Münster, 48149 Münster, Germany', 'institution_ids': ['https://openalex.org/I4210103666']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5076241569', 'display_name': 'Peter Bokník', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210103666', 'display_name': 'University Hospital Münster', 'ror': 'https://ror.org/01856cw59', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210103666']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Peter Boknik', 'raw_affiliation_strings': ['Institut für Pharmakologie und Toxikologie, Universitätsklinikum Münster, 48149 Münster, Germany'], 'affiliations': [{'raw_affiliation_string': 'Institut für Pharmakologie und Toxikologie, Universitätsklinikum Münster, 48149 Münster, Germany', 'institution_ids': ['https://openalex.org/I4210103666']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 1.784, 'has_fulltext': False, 'cited_by_count': 44, 'citation_normalized_percentile': {'value': 0.999985, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '289', 'issue': '1', 'first_page': '163', 'last_page': '176'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10169', 'display_name': 'Molecular Mechanisms of Ras Signaling Pathways', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10169', 'display_name': 'Molecular Mechanisms of Ras Signaling Pathways', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12827', 'display_name': 'Nucleotide Metabolism and Enzyme Regulation', 'score': 0.9953, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10493', 'display_name': 'Molecular Mechanisms of Ion Channels Regulation', 'score': 0.9845, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/dephosphorylation', 'display_name': 'Dephosphorylation', 'score': 0.5141149}, {'id': 'https://openalex.org/keywords/protein-kinases', 'display_name': 'Protein Kinases', 'score': 0.495945}], 'concepts': [{'id': 'https://openalex.org/C389152', 'wikidata': 'https://www.wikidata.org/wiki/Q6593007', 'display_name': 'Protein phosphatase 2', 'level': 4, 'score': 0.8785142}, {'id': 'https://openalex.org/C11960822', 'wikidata': 'https://www.wikidata.org/wiki/Q242736', 'display_name': 'Phosphorylation', 'level': 2, 'score': 0.86423105}, {'id': 'https://openalex.org/C195794163', 'wikidata': 'https://www.wikidata.org/wiki/Q420877', 'display_name': 'Protein kinase C', 'level': 3, 'score': 0.6625364}, {'id': 'https://openalex.org/C178666793', 'wikidata': 'https://www.wikidata.org/wiki/Q422476', 'display_name': 'Phosphatase', 'level': 3, 'score': 0.6311659}, {'id': 'https://openalex.org/C2776414213', 'wikidata': 'https://www.wikidata.org/wiki/Q183290', 'display_name': 'Serine', 'level': 3, 'score': 0.6276049}, {'id': 'https://openalex.org/C104292427', 'wikidata': 'https://www.wikidata.org/wiki/Q899781', 'display_name': 'Protein subunit', 'level': 3, 'score': 0.59610116}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.5260672}, {'id': 'https://openalex.org/C181912034', 'wikidata': 'https://www.wikidata.org/wiki/Q1101143', 'display_name': 'Dephosphorylation', 'level': 4, 'score': 0.5141149}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.49233305}, {'id': 'https://openalex.org/C2775880066', 'wikidata': 'https://www.wikidata.org/wiki/Q186521', 'display_name': 'Threonine', 'level': 4, 'score': 0.4660816}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.4578802}, {'id': 'https://openalex.org/C97029542', 'wikidata': 'https://www.wikidata.org/wiki/Q281417', 'display_name': 'Protein kinase A', 'level': 3, 'score': 0.45443597}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.4346075}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D002118', 'descriptor_name': 'Calcium', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D004721', 'descriptor_name': 'Endoplasmic Reticulum', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D006706', 'descriptor_name': 'Homeostasis', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D051571', 'descriptor_name': 'Protein Kinase C-alpha', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D054648', 'descriptor_name': 'Protein Phosphatase 2', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D058646', 'descriptor_name': 'Adrenergic alpha-1 Receptor Agonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058646', 'descriptor_name': 'Adrenergic alpha-1 Receptor Agonists', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D019943', 'descriptor_name': 'Amino Acid Substitution', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002118', 'descriptor_name': 'Calcium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004721', 'descriptor_name': 'Endoplasmic Reticulum', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004721', 'descriptor_name': 'Endoplasmic Reticulum', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D057809', 'descriptor_name': 'HEK293 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006706', 'descriptor_name': 'Homeostasis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006706', 'descriptor_name': 'Homeostasis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020125', 'descriptor_name': 'Mutation, Missense', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010656', 'descriptor_name': 'Phenylephrine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010656', 'descriptor_name': 'Phenylephrine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D051571', 'descriptor_name': 'Protein Kinase C-alpha', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051571', 'descriptor_name': 'Protein Kinase C-alpha', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D054648', 'descriptor_name': 'Protein Phosphatase 2', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D054648', 'descriptor_name': 'Protein Phosphatase 2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012694', 'descriptor_name': 'Serine', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012694', 'descriptor_name': 'Serine', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012694', 'descriptor_name': 'Serine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D061987', 'descriptor_name': 'Sf9 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018411', 'descriptor_name': 'Spodoptera', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m113.507996', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3879541', 'pdf_url': 'https://europepmc.org/articles/pmc3879541?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879541', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/24225947', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m113.507996', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 57, 'referenced_works': ['https://openalex.org/W1577577364', 'https://openalex.org/W1966049529', 'https://openalex.org/W1971626394', 'https://openalex.org/W1971695868', 'https://openalex.org/W1973630093', 'https://openalex.org/W1974173448', 'https://openalex.org/W1974535915', 'https://openalex.org/W1977599918', 'https://openalex.org/W1977703065', 'https://openalex.org/W1980242148', 'https://openalex.org/W1984128917', 'https://openalex.org/W1987528621', 'https://openalex.org/W1988824838', 'https://openalex.org/W1991320072', 'https://openalex.org/W1997079073', 'https://openalex.org/W1999793253', 'https://openalex.org/W2007194671', 'https://openalex.org/W2017075655', 'https://openalex.org/W2018537340', 'https://openalex.org/W2033598954', 'https://openalex.org/W2035705986', 'https://openalex.org/W2041785538', 'https://openalex.org/W2050703700', 'https://openalex.org/W2055493976', 'https://openalex.org/W2062158492', 'https://openalex.org/W2063123880', 'https://openalex.org/W2066893159', 'https://openalex.org/W2070544692', 'https://openalex.org/W2074386808', 'https://openalex.org/W2076945543', 'https://openalex.org/W2079047912', 'https://openalex.org/W2081280187', 'https://openalex.org/W2092312719', 'https://openalex.org/W2092953381', 'https://openalex.org/W2096875864', 'https://openalex.org/W2099249565', 'https://openalex.org/W2099686283', 'https://openalex.org/W2100837269', 'https://openalex.org/W2106474320', 'https://openalex.org/W2114096240', 'https://openalex.org/W2126167700', 'https://openalex.org/W2126361876', 'https://openalex.org/W2127426595', 'https://openalex.org/W2139244522', 'https://openalex.org/W2139541709', 'https://openalex.org/W2147023594', 'https://openalex.org/W2157178116', 'https://openalex.org/W2165292955', 'https://openalex.org/W2169617094', 'https://openalex.org/W2170494228', 'https://openalex.org/W2312340834', 'https://openalex.org/W2315965467', 'https://openalex.org/W2415572742', 'https://openalex.org/W2475819978', 'https://openalex.org/W4235491773', 'https://openalex.org/W4237496848', 'https://openalex.org/W4240253200'], 'related_works': ['https://openalex.org/W4239029233', 'https://openalex.org/W3165929206', 'https://openalex.org/W3025957543', 'https://openalex.org/W2399418957', 'https://openalex.org/W2168642368', 'https://openalex.org/W2147519392', 'https://openalex.org/W2056779425', 'https://openalex.org/W1993181715', 'https://openalex.org/W1991320072', 'https://openalex.org/W1971335607'], 'abstract_inverted_index': {'Protein': [0], 'phosphatase': [1], '2A': [2], '(PP2A)': [3], 'is': [4], 'a': [5, 13, 16, 20, 79, 100, 151, 168, 229], 'family': [6], 'of': [7, 12, 31, 38, 62, 71, 85, 104, 130, 171, 174, 197, 218], 'multifunctional': [8], 'serine/threonine': [9], 'phosphatases': [10], 'consisting': [11], 'catalytic': [14], 'C,': [15], 'structural': [17], 'A,': [18], 'and': [19, 26, 120, 226], 'regulatory': [21, 45], 'B': [22, 46], 'subunit.': [23], 'The': [24, 128, 186], 'substrate': [25], 'therefore': [27], 'the': [28, 36, 39, 43, 69, 198], 'functional': [29, 169], 'specificity': [30], 'PP2A': [32, 64, 115, 133, 141, 214, 227], 'are': [33], 'determined': [34], 'by': [35, 96, 138, 159, 193, 195, 216], 'assembly': [37], 'enzyme': [40], 'complex': [41], 'with': [42, 111, 150, 202], 'appropriate': [44], 'subunit': [47], 'families,': [48], 'namely': [49], 'B55,': [50], 'B56,': [51], 'PR72,': [52], 'or': [53], 'PR93/PR110.': [54], 'It': [55], 'has': [56], 'been': [57], 'suggested': [58], 'that': [59, 210], 'additional': [60], 'levels': [61], 'regulating': [63], 'function': [65], 'may': [66], 'result': [67], 'from': [68, 178], 'phosphorylation': [70, 81, 103, 173, 217], 'B56': [72], 'isoforms.': [73], 'In': [74], 'this': [75], 'study,': [76], 'we': [77], 'identified': [78], 'novel': [80], 'site': [82], 'at': [83, 220], 'Ser<sup>41</sup>': [84], 'B56α.': [86, 127, 204], 'This': [87, 222], 'phosphoamino': [88], 'acid': [89], 'residue': [90], 'was': [91, 122, 135, 143, 157, 176, 191], 'efficiently': [92], 'phosphorylated': [93], '<i>in': [94], 'vitro</i>': [95], 'PKCα.': [97], 'We': [98], 'detected': [99], '7-fold': [101], 'higher': [102], 'B56α': [105, 131, 152, 175, 219], 'in': [106, 146, 182], 'failing': [107], 'human': [108], 'hearts': [109], 'compared': [110, 201], 'nonfailing': [112], 'hearts.': [113], 'Purified': [114], 'dimeric': [116], 'holoenzyme': [117], '(subunits': [118], 'C': [119], 'A)': [121], 'able': [123], 'to': [124, 232], 'dephosphorylate': [125], 'PKCα-phosphorylated': [126], 'potency': [129], 'for': [132, 167], 'inhibition': [134], 'markedly': [136], 'increased': [137, 192], 'PKCα': [139, 211, 225], 'phosphorylation.': [140, 164], 'activity': [142, 215], 'also': [144], 'reduced': [145], 'HEK293': [147], 'cells': [148], 'transfected': [149], 'mutant,': [153], 'where': [154], 'serine': [155], '41': [156], 'replaced': [158], 'aspartic': [160], 'acid,': [161], 'which': [162], 'mimics': [163], 'More': [165], 'evidence': [166], 'role': [170], 'PKCα-dependent': [172], 'derived': [177], 'Fluo-4': [179], 'fluorescence': [180], 'measurements': [181], 'phenylephrine-stimulated': [183], 'Flp293': [184], 'cells.': [185], 'endoplasmic': [187], 'reticulum': [188], 'Ca<sup>2+</sup>': [189, 239], 'release': [190], '23%': [194], 'expression': [196], 'pseudophosphorylated': [199], 'form': [200], 'wild-type': [203], 'Taken': [205], 'together,': [206], 'our': [207], 'results': [208], 'suggest': [209], 'can': [212], 'modify': [213], 'Ser<sup>41</sup>.': [221], 'interplay': [223], 'between': [224], 'represents': [228], 'new': [230], 'mechanism': [231], 'regulate': [233], 'important': [234], 'cellular': [235, 238], 'functions': [236], 'like': [237], 'homeostasis.': [240]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2045160978', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 7}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 7}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 4}], 'updated_date': '2024-09-17T15:41:08.827212', 'created_date': '2016-06-24'}