Title: Identification of Tyrosinase Inhibitors from<i>Glycyrrhiza uralensis</i>
Abstract: Tyrosinase is a key enzyme in the production of melanins. Phytochemical studies of a Glycyrrhiza uralensis extract were performed by measuring the tyrosinase and melanin synthesis inhibitory activity. Glycyrrhisoflavone and glyasperin C were identified as tyrosinase inhibitors for the first time. Glyasperin C showed a stronger tyrosinase inhibitory activity (IC50 = 0.13 ± 0.01 μg/mL) than glabridin (IC50 = 0.25 ± 0.01 μg/mL) and a moderate inhibition of melanin production (17.65 ± 8.8 % at 5 μg/mL). Glycyrrhisoflavone showed a strong melanin synthesis inhibitory activity (63.73 ± 6.8 % inhibition at 5 μg/mL). These results suggest that glyasperin C and glycyrrhisoflavone could be promising candidates in the design of skin-whitening agents.
Publication Year: 2005
Publication Date: 2005-08-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 48
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