Resetting Transcription Factor Control Circuitry toward Ground-State Pluripotency in Human

Name: Work Video:
Duration: 3 min 30 s
Yasuhiro Takashima; Ge Guo; Remco Loos; Jennifer Nichols; Gabriella Ficz; Felix Krueger; David Oxley; Fátima Santos; James Clarke; W Mansfield; Wolf Reik; Paul Bertone; Austin Smith
{'id': 'https://openalex.org/W2045067641', 'doi': 'https://doi.org/10.1016/j.cell.2014.08.029', 'title': 'Resetting Transcription Factor Control Circuitry toward Ground-State Pluripotency in Human', 'display_name': 'Resetting Transcription Factor Control Circuitry toward Ground-State Pluripotency in Human', 'publication_year': 2014, 'publication_date': '2014-09-01', 'ids': {'openalex': 'https://openalex.org/W2045067641', 'doi': 'https://doi.org/10.1016/j.cell.2014.08.029', 'mag': '2045067641', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/28843285', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5628177'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.cell.2014.08.029', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S110447773', 'display_name': 'Cell', 'issn_l': '0092-8674', 'issn': ['0092-8674', '1097-4172'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315673', 'host_organization_name': 'Cell Press', 'host_organization_lineage': ['https://openalex.org/P4310320990', 'https://openalex.org/P4310315673'], 'host_organization_lineage_names': ['Elsevier BV', 'Cell Press'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://doi.org/10.1016/j.cell.2014.08.029', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5058839064', 'display_name': 'Yasuhiro Takashima', 'orcid': 'https://orcid.org/0000-0003-0126-7260'}, 'institutions': [{'id': 'https://openalex.org/I4210086780', 'display_name': 'Japan Science and Technology Agency', 'ror': 'https://ror.org/00097mb19', 'country_code': 'JP', 'type': 'government', 'lineage': ['https://openalex.org/I4210086780']}, {'id': 'https://openalex.org/I21196054', 'display_name': 'Wellcome/MRC Cambridge Stem Cell Institute', 'ror': 'https://ror.org/05nz0zp31', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I21196054', 'https://openalex.org/I241749', 'https://openalex.org/I4210087105', 'https://openalex.org/I87048295', 'https://openalex.org/I90344618']}, {'id': 'https://openalex.org/I90344618', 'display_name': 'Medical Research Council', 'ror': 'https://ror.org/03x94j517', 'country_code': 'GB', 'type': 'government', 'lineage': ['https://openalex.org/I4210087105', 'https://openalex.org/I90344618']}, {'id': 'https://openalex.org/I241749', 'display_name': 'University of Cambridge', 'ror': 'https://ror.org/013meh722', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I241749']}], 'countries': ['GB', 'JP'], 'is_corresponding': False, 'raw_author_name': 'Yasuhiro Takashima', 'raw_affiliation_strings': ['PRESTO, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, Saitama, 332-0012, Japan', 'Wellcome Trust–Medical Research Council Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK'], 'affiliations': [{'raw_affiliation_string': 'PRESTO, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, Saitama, 332-0012, Japan', 'institution_ids': ['https://openalex.org/I4210086780']}, {'raw_affiliation_string': 'Wellcome Trust–Medical Research Council Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK', 'institution_ids': ['https://openalex.org/I21196054', 'https://openalex.org/I90344618', 'https://openalex.org/I241749']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050392088', 'display_name': 'Ge Guo', 'orcid': 'https://orcid.org/0000-0002-3273-9147'}, 'institutions': [{'id': 'https://openalex.org/I90344618', 'display_name': 'Medical Research Council', 'ror': 'https://ror.org/03x94j517', 'country_code': 'GB', 'type': 'government', 'lineage': ['https://openalex.org/I4210087105', 'https://openalex.org/I90344618']}, {'id': 'https://openalex.org/I241749', 'display_name': 'University of Cambridge', 'ror': 'https://ror.org/013meh722', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I241749']}, {'id': 'https://openalex.org/I21196054', 'display_name': 'Wellcome/MRC Cambridge Stem Cell Institute', 'ror': 'https://ror.org/05nz0zp31', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I21196054', 'https://openalex.org/I241749', 'https://openalex.org/I4210087105', 'https://openalex.org/I87048295', 'https://openalex.org/I90344618']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Ge Guo', 'raw_affiliation_strings': ['Wellcome Trust–Medical Research Council Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK'], 'affiliations': [{'raw_affiliation_string': 'Wellcome Trust–Medical Research Council Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK', 'institution_ids': ['https://openalex.org/I90344618', 'https://openalex.org/I241749', 'https://openalex.org/I21196054']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5107974625', 'display_name': 'Remco Loos', 'orcid': 'https://orcid.org/0000-0002-9850-6821'}, 'institutions': [{'id': 'https://openalex.org/I87048295', 'display_name': 'Wellcome Trust', 'ror': 'https://ror.org/029chgv08', 'country_code': 'GB', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I87048295']}, {'id': 'https://openalex.org/I21196054', 'display_name': 'Wellcome/MRC Cambridge Stem Cell Institute', 'ror': 'https://ror.org/05nz0zp31', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I21196054', 'https://openalex.org/I241749', 'https://openalex.org/I4210087105', 'https://openalex.org/I87048295', 'https://openalex.org/I90344618']}, {'id': 'https://openalex.org/I90344618', 'display_name': 'Medical Research Council', 'ror': 'https://ror.org/03x94j517', 'country_code': 'GB', 'type': 'government', 'lineage': ['https://openalex.org/I4210087105', 'https://openalex.org/I90344618']}, {'id': 'https://openalex.org/I241749', 'display_name': 'University of Cambridge', 'ror': 'https://ror.org/013meh722', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I241749']}, {'id': 'https://openalex.org/I1303153112', 'display_name': 'European Bioinformatics Institute', 'ror': 'https://ror.org/02catss52', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I1303153112', 'https://openalex.org/I4210138560']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Remco Loos', 'raw_affiliation_strings': ['European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SD, UK', 'Wellcome Trust–Medical Research Council Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK'], 'affiliations': [{'raw_affiliation_string': 'European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SD, UK', 'institution_ids': ['https://openalex.org/I87048295', 'https://openalex.org/I1303153112']}, {'raw_affiliation_string': 'Wellcome Trust–Medical Research Council Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK', 'institution_ids': ['https://openalex.org/I21196054', 'https://openalex.org/I90344618', 'https://openalex.org/I241749']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008565592', 'display_name': 'Jennifer Nichols', 'orcid': 'https://orcid.org/0000-0002-8650-1388'}, 'institutions': [{'id': 'https://openalex.org/I241749', 'display_name': 'University of Cambridge', 'ror': 'https://ror.org/013meh722', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I241749']}, {'id': 'https://openalex.org/I21196054', 'display_name': 'Wellcome/MRC Cambridge Stem Cell Institute', 'ror': 'https://ror.org/05nz0zp31', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I21196054', 'https://openalex.org/I241749', 'https://openalex.org/I4210087105', 'https://openalex.org/I87048295', 'https://openalex.org/I90344618']}, {'id': 'https://openalex.org/I90344618', 'display_name': 'Medical Research Council', 'ror': 'https://ror.org/03x94j517', 'country_code': 'GB', 'type': 'government', 'lineage': ['https://openalex.org/I4210087105', 'https://openalex.org/I90344618']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Jennifer Nichols', 'raw_affiliation_strings': ['Department of Physiology, Development, and Neuroscience, University of Cambridge, Tennis Court Road, Cambridge CB2 3EG, UK', 'Wellcome Trust–Medical Research Council Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK'], 'affiliations': [{'raw_affiliation_string': 'Department of Physiology, Development, and Neuroscience, University of Cambridge, Tennis Court Road, Cambridge CB2 3EG, UK', 'institution_ids': ['https://openalex.org/I241749']}, {'raw_affiliation_string': 'Wellcome Trust–Medical Research Council Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK', 'institution_ids': ['https://openalex.org/I21196054', 'https://openalex.org/I90344618', 'https://openalex.org/I241749']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051622432', 'display_name': 'Gabriella Ficz', 'orcid': 'https://orcid.org/0000-0001-9313-9578'}, 'institutions': [{'id': 'https://openalex.org/I124357947', 'display_name': 'University of London', 'ror': 'https://ror.org/04cw6st05', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Gabriella Ficz', 'raw_affiliation_strings': ['Centre for Haemato-Oncology, Barts Cancer Institute, University of London, Charterhouse Square, London EC1M 6BQ, UK'], 'affiliations': [{'raw_affiliation_string': 'Centre for Haemato-Oncology, Barts Cancer Institute, University of London, Charterhouse Square, London EC1M 6BQ, UK', 'institution_ids': ['https://openalex.org/I124357947']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5066726255', 'display_name': 'Felix Krueger', 'orcid': 'https://orcid.org/0000-0002-5513-3324'}, 'institutions': [{'id': 'https://openalex.org/I1302113299', 'display_name': 'Babraham Institute', 'ror': 'https://ror.org/01d5qpn59', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I1302113299', 'https://openalex.org/I2799693246', 'https://openalex.org/I4210087105']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Felix Krueger', 'raw_affiliation_strings': ['Babraham Institute, Babraham, CB22 3AT, UK'], 'affiliations': [{'raw_affiliation_string': 'Babraham Institute, Babraham, CB22 3AT, UK', 'institution_ids': ['https://openalex.org/I1302113299']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112270869', 'display_name': 'David Oxley', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1302113299', 'display_name': 'Babraham Institute', 'ror': 'https://ror.org/01d5qpn59', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I1302113299', 'https://openalex.org/I2799693246', 'https://openalex.org/I4210087105']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'David Oxley', 'raw_affiliation_strings': ['Babraham Institute, Babraham, CB22 3AT, UK'], 'affiliations': [{'raw_affiliation_string': 'Babraham Institute, Babraham, CB22 3AT, UK', 'institution_ids': ['https://openalex.org/I1302113299']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5063078130', 'display_name': 'Fátima Santos', 'orcid': 'https://orcid.org/0000-0002-3854-4084'}, 'institutions': [{'id': 'https://openalex.org/I1302113299', 'display_name': 'Babraham Institute', 'ror': 'https://ror.org/01d5qpn59', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I1302113299', 'https://openalex.org/I2799693246', 'https://openalex.org/I4210087105']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Fatima Santos', 'raw_affiliation_strings': ['Babraham Institute, Babraham, CB22 3AT, UK'], 'affiliations': [{'raw_affiliation_string': 'Babraham Institute, Babraham, CB22 3AT, UK', 'institution_ids': ['https://openalex.org/I1302113299']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045332430', 'display_name': 'James Clarke', 'orcid': 'https://orcid.org/0009-0001-8803-4728'}, 'institutions': [{'id': 'https://openalex.org/I21196054', 'display_name': 'Wellcome/MRC Cambridge Stem Cell Institute', 'ror': 'https://ror.org/05nz0zp31', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I21196054', 'https://openalex.org/I241749', 'https://openalex.org/I4210087105', 'https://openalex.org/I87048295', 'https://openalex.org/I90344618']}, {'id': 'https://openalex.org/I90344618', 'display_name': 'Medical Research Council', 'ror': 'https://ror.org/03x94j517', 'country_code': 'GB', 'type': 'government', 'lineage': ['https://openalex.org/I4210087105', 'https://openalex.org/I90344618']}, {'id': 'https://openalex.org/I241749', 'display_name': 'University of Cambridge', 'ror': 'https://ror.org/013meh722', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I241749']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'James Clarke', 'raw_affiliation_strings': ['Wellcome Trust–Medical Research Council Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK'], 'affiliations': [{'raw_affiliation_string': 'Wellcome Trust–Medical Research Council Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK', 'institution_ids': ['https://openalex.org/I21196054', 'https://openalex.org/I90344618', 'https://openalex.org/I241749']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002055593', 'display_name': 'W Mansfield', 'orcid': 'https://orcid.org/0000-0002-4299-5590'}, 'institutions': [{'id': 'https://openalex.org/I21196054', 'display_name': 'Wellcome/MRC Cambridge Stem Cell Institute', 'ror': 'https://ror.org/05nz0zp31', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I21196054', 'https://openalex.org/I241749', 'https://openalex.org/I4210087105', 'https://openalex.org/I87048295', 'https://openalex.org/I90344618']}, {'id': 'https://openalex.org/I90344618', 'display_name': 'Medical Research Council', 'ror': 'https://ror.org/03x94j517', 'country_code': 'GB', 'type': 'government', 'lineage': ['https://openalex.org/I4210087105', 'https://openalex.org/I90344618']}, {'id': 'https://openalex.org/I241749', 'display_name': 'University of Cambridge', 'ror': 'https://ror.org/013meh722', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I241749']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'William Mansfield', 'raw_affiliation_strings': ['Wellcome Trust–Medical Research Council Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK'], 'affiliations': [{'raw_affiliation_string': 'Wellcome Trust–Medical Research Council Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK', 'institution_ids': ['https://openalex.org/I21196054', 'https://openalex.org/I90344618', 'https://openalex.org/I241749']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052074743', 'display_name': 'Wolf Reik', 'orcid': 'https://orcid.org/0000-0003-0216-9881'}, 'institutions': [{'id': 'https://openalex.org/I2802476451', 'display_name': 'Wellcome Sanger Institute', 'ror': 'https://ror.org/05cy4wa09', 'country_code': 'GB', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2802476451', 'https://openalex.org/I87048295']}, {'id': 'https://openalex.org/I1302113299', 'display_name': 'Babraham Institute', 'ror': 'https://ror.org/01d5qpn59', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I1302113299', 'https://openalex.org/I2799693246', 'https://openalex.org/I4210087105']}, {'id': 'https://openalex.org/I241749', 'display_name': 'University of Cambridge', 'ror': 'https://ror.org/013meh722', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I241749']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Wolf Reik', 'raw_affiliation_strings': ['Babraham Institute, Babraham, CB22 3AT, UK', 'Centre for Trophoblast Research, University of Cambridge, Tennis Court Road, Cambridge CB2 3EG, UK', 'Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK'], 'affiliations': [{'raw_affiliation_string': 'Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK', 'institution_ids': ['https://openalex.org/I2802476451']}, {'raw_affiliation_string': 'Babraham Institute, Babraham, CB22 3AT, UK', 'institution_ids': ['https://openalex.org/I1302113299']}, {'raw_affiliation_string': 'Centre for Trophoblast Research, University of Cambridge, Tennis Court Road, Cambridge CB2 3EG, UK', 'institution_ids': ['https://openalex.org/I241749']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5023094545', 'display_name': 'Paul Bertone', 'orcid': 'https://orcid.org/0000-0001-5059-4829'}, 'institutions': [{'id': 'https://openalex.org/I1303153112', 'display_name': 'European Bioinformatics Institute', 'ror': 'https://ror.org/02catss52', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I1303153112', 'https://openalex.org/I4210138560']}, {'id': 'https://openalex.org/I87048295', 'display_name': 'Wellcome Trust', 'ror': 'https://ror.org/029chgv08', 'country_code': 'GB', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I87048295']}, {'id': 'https://openalex.org/I4210153543', 'display_name': 'European Molecular Biology Laboratory', 'ror': 'https://ror.org/050589e39', 'country_code': 'DE', 'type': 'government', 'lineage': ['https://openalex.org/I4210138560', 'https://openalex.org/I4210153543']}, {'id': 'https://openalex.org/I21196054', 'display_name': 'Wellcome/MRC Cambridge Stem Cell Institute', 'ror': 'https://ror.org/05nz0zp31', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I21196054', 'https://openalex.org/I241749', 'https://openalex.org/I4210087105', 'https://openalex.org/I87048295', 'https://openalex.org/I90344618']}, {'id': 'https://openalex.org/I90344618', 'display_name': 'Medical Research Council', 'ror': 'https://ror.org/03x94j517', 'country_code': 'GB', 'type': 'government', 'lineage': ['https://openalex.org/I4210087105', 'https://openalex.org/I90344618']}, {'id': 'https://openalex.org/I241749', 'display_name': 'University of Cambridge', 'ror': 'https://ror.org/013meh722', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I241749']}], 'countries': ['DE', 'GB'], 'is_corresponding': False, 'raw_author_name': 'Paul Bertone', 'raw_affiliation_strings': ['European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SD, UK', 'Genome Biology and Developmental Biology Units, European Molecular Biology Laboratory, Meyerhofstraβe 1, 69117 Heidelberg, Germany', 'Wellcome Trust–Medical Research Council Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK'], 'affiliations': [{'raw_affiliation_string': 'European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SD, UK', 'institution_ids': ['https://openalex.org/I1303153112', 'https://openalex.org/I87048295']}, {'raw_affiliation_string': 'Genome Biology and Developmental Biology Units, European Molecular Biology Laboratory, Meyerhofstraβe 1, 69117 Heidelberg, Germany', 'institution_ids': ['https://openalex.org/I4210153543']}, {'raw_affiliation_string': 'Wellcome Trust–Medical Research Council Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK', 'institution_ids': ['https://openalex.org/I21196054', 'https://openalex.org/I90344618', 'https://openalex.org/I241749']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5054950667', 'display_name': 'Austin Smith', 'orcid': 'https://orcid.org/0000-0002-3029-4682'}, 'institutions': [{'id': 'https://openalex.org/I21196054', 'display_name': 'Wellcome/MRC Cambridge Stem Cell Institute', 'ror': 'https://ror.org/05nz0zp31', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I21196054', 'https://openalex.org/I241749', 'https://openalex.org/I4210087105', 'https://openalex.org/I87048295', 'https://openalex.org/I90344618']}, {'id': 'https://openalex.org/I90344618', 'display_name': 'Medical Research Council', 'ror': 'https://ror.org/03x94j517', 'country_code': 'GB', 'type': 'government', 'lineage': ['https://openalex.org/I4210087105', 'https://openalex.org/I90344618']}, {'id': 'https://openalex.org/I241749', 'display_name': 'University of Cambridge', 'ror': 'https://ror.org/013meh722', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I241749']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Austin Smith', 'raw_affiliation_strings': ['Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, UK', 'Wellcome Trust–Medical Research Council Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK'], 'affiliations': [{'raw_affiliation_string': 'Wellcome Trust–Medical Research Council Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK', 'institution_ids': ['https://openalex.org/I21196054', 'https://openalex.org/I90344618', 'https://openalex.org/I241749']}, {'raw_affiliation_string': 'Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, UK', 'institution_ids': ['https://openalex.org/I241749']}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 10, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 10100, 'currency': 'USD', 'value_usd': 10100, 'provenance': 'doaj'}, 'apc_paid': {'value': 10100, 'currency': 'USD', 'value_usd': 10100, 'provenance': 'doaj'}, 'fwci': 37.32, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 868, 'citation_normalized_percentile': {'value': 0.999985, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '158', 'issue': '6', 'first_page': '1254', 'last_page': '1269'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10505', 'display_name': 'Pluripotent Stem Cells Research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10505', 'display_name': 'Pluripotent Stem Cells Research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10878', 'display_name': 'CRISPR and Genetic Engineering', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetics and DNA Methylation', 'score': 0.9954, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/homeobox-protein-nanog', 'display_name': 'Homeobox protein NANOG', 'score': 0.63533247}, {'id': 'https://openalex.org/keywords/rex1', 'display_name': 'Rex1', 'score': 0.48798102}, {'id': 'https://openalex.org/keywords/klf4', 'display_name': 'KLF4', 'score': 0.4402481}, {'id': 'https://openalex.org/keywords/cell-potency', 'display_name': 'Cell potency', 'score': 0.42341125}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.8901684}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.7319052}, {'id': 'https://openalex.org/C207701140', 'wikidata': 'https://www.wikidata.org/wiki/Q420522', 'display_name': 'Homeobox protein NANOG', 'level': 5, 'score': 0.63533247}, {'id': 'https://openalex.org/C107459253', 'wikidata': 'https://www.wikidata.org/wiki/Q674925', 'display_name': 'Induced pluripotent stem cell', 'level': 4, 'score': 0.6070759}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.5346782}, {'id': 'https://openalex.org/C207168726', 'wikidata': 'https://www.wikidata.org/wiki/Q18050439', 'display_name': 'Rex1', 'level': 5, 'score': 0.48798102}, {'id': 'https://openalex.org/C145103041', 'wikidata': 'https://www.wikidata.org/wiki/Q1151519', 'display_name': 'Embryonic stem cell', 'level': 3, 'score': 0.46543872}, {'id': 'https://openalex.org/C28328180', 'wikidata': 'https://www.wikidata.org/wiki/Q48196', 'display_name': 'Stem cell', 'level': 2, 'score': 0.4548006}, {'id': 'https://openalex.org/C2778265714', 'wikidata': 'https://www.wikidata.org/wiki/Q18033993', 'display_name': 'KLF4', 'level': 5, 'score': 0.4402481}, {'id': 'https://openalex.org/C27390768', 'wikidata': 'https://www.wikidata.org/wiki/Q862600', 'display_name': 'Cell potency', 'level': 5, 'score': 0.42341125}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.3061461}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D018398', 'descriptor_name': 'Homeodomain Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D051741', 'descriptor_name': 'Kruppel-Like Transcription Factors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003584', 'descriptor_name': 'Cytological Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053595', 'descriptor_name': 'Embryonic Stem Cells', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D044127', 'descriptor_name': 'Epigenesis, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000090062', 'descriptor_name': 'Kruppel-Like Factor 4', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000071317', 'descriptor_name': 'Nanog Homeobox Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D039904', 'descriptor_name': 'Pluripotent Stem Cells', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D059467', 'descriptor_name': 'Transcriptome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.cell.2014.08.029', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S110447773', 'display_name': 'Cell', 'issn_l': '0092-8674', 'issn': ['0092-8674', '1097-4172'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315673', 'host_organization_name': 'Cell Press', 'host_organization_lineage': ['https://openalex.org/P4310320990', 'https://openalex.org/P4310315673'], 'host_organization_lineage_names': ['Elsevier BV', 'Cell Press'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.repository.cam.ac.uk/handle/1810/286042', 'pdf_url': 'https://www.repository.cam.ac.uk/bitstreams/ad04e146-6e28-44f1-864a-e6755a0e06af/download', 'source': {'id': 'https://openalex.org/S4306401777', 'display_name': 'Apollo (University of Cambridge)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I241749', 'host_organization_name': 'University of Cambridge', 'host_organization_lineage': ['https://openalex.org/I241749'], 'host_organization_lineage_names': ['University of Cambridge'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4162745', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162745', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/25215486', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.cell.2014.08.029', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S110447773', 'display_name': 'Cell', 'issn_l': '0092-8674', 'issn': ['0092-8674', '1097-4172'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315673', 'host_organization_name': 'Cell Press', 'host_organization_lineage': ['https://openalex.org/P4310320990', 'https://openalex.org/P4310315673'], 'host_organization_lineage_names': ['Elsevier BV', 'Cell Press'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Life on land', 'id': 'https://metadata.un.org/sdg/15', 'score': 0.5}, {'display_name': 'Responsible consumption and production', 'id': 'https://metadata.un.org/sdg/12', 'score': 0.49}], 'grants': [{'funder': 'https://openalex.org/F4320307874', 'funder_display_name': 'Wellcome', 'award_id': None}, {'funder': 'https://openalex.org/F4320314023', 'funder_display_name': 'European Molecular Biology Laboratory', 'award_id': None}, {'funder': 'https://openalex.org/F4320334626', 'funder_display_name': 'Medical Research Council', 'award_id': None}, {'funder': 'https://openalex.org/F4320334789', 'funder_display_name': 'Japan Science and Technology Agency', 'award_id': None}], 'datasets': [], 'versions': [], 'referenced_works_count': 70, 'referenced_works': ['https://openalex.org/W1874303456', 'https://openalex.org/W1904046622', 'https://openalex.org/W1970084119', 'https://openalex.org/W1972564906', 'https://openalex.org/W1975200987', 'https://openalex.org/W1981197560', 'https://openalex.org/W1984077980', 'https://openalex.org/W1985439298', 'https://openalex.org/W1985658425', 'https://openalex.org/W1992603073', 'https://openalex.org/W1994596013', 'https://openalex.org/W1994758141', 'https://openalex.org/W1998070636', 'https://openalex.org/W2005617468', 'https://openalex.org/W2007439698', 'https://openalex.org/W2009771946', 'https://openalex.org/W2030362521', 'https://openalex.org/W2031285837', 'https://openalex.org/W2035047647', 'https://openalex.org/W2036326229', 'https://openalex.org/W2043473476', 'https://openalex.org/W2044120077', 'https://openalex.org/W2053056178', 'https://openalex.org/W2053860318', 'https://openalex.org/W2054576015', 'https://openalex.org/W2058521801', 'https://openalex.org/W2064037605', 'https://openalex.org/W2065731136', 'https://openalex.org/W2068650840', 'https://openalex.org/W2069043023', 'https://openalex.org/W2074591015', 'https://openalex.org/W2076612253', 'https://openalex.org/W2084201375', 'https://openalex.org/W2085884630', 'https://openalex.org/W2086943348', 'https://openalex.org/W2087786585', 'https://openalex.org/W2088128367', 'https://openalex.org/W2090260381', 'https://openalex.org/W2091514601', 'https://openalex.org/W2093822374', 'https://openalex.org/W2094099211', 'https://openalex.org/W2096465161', 'https://openalex.org/W2101771613', 'https://openalex.org/W2105241566', 'https://openalex.org/W2106219965', 'https://openalex.org/W2107202213', 'https://openalex.org/W2110702717', 'https://openalex.org/W2111888363', 'https://openalex.org/W2112014972', 'https://openalex.org/W2126432370', 'https://openalex.org/W2131374955', 'https://openalex.org/W2133501984', 'https://openalex.org/W2133703873', 'https://openalex.org/W2134526812', 'https://openalex.org/W2138035159', 'https://openalex.org/W2142482111', 'https://openalex.org/W2148708580', 'https://openalex.org/W2149236471', 'https://openalex.org/W2151870437', 'https://openalex.org/W2152239989', 'https://openalex.org/W2163092257', 'https://openalex.org/W2167010568', 'https://openalex.org/W2169456326', 'https://openalex.org/W2170989872', 'https://openalex.org/W2171109270', 'https://openalex.org/W2595539433', 'https://openalex.org/W2952535963', 'https://openalex.org/W4210767115', 'https://openalex.org/W4232123484', 'https://openalex.org/W64811814'], 'related_works': ['https://openalex.org/W4313471925', 'https://openalex.org/W3145626050', 'https://openalex.org/W2963000833', 'https://openalex.org/W2355629952', 'https://openalex.org/W2134030824', 'https://openalex.org/W2117623697', 'https://openalex.org/W2109250023', 'https://openalex.org/W2011126334', 'https://openalex.org/W1994993245', 'https://openalex.org/W1978560791'], 'abstract_inverted_index': {'Current': [0], 'human': [1, 45, 122, 146], 'pluripotent': [2, 46, 123], 'stem': [3, 18, 124], 'cells': [4, 19, 61, 125], 'lack': [5], 'the': [6, 12, 40, 44, 128], 'transcription': [7, 112], 'factor': [8], 'circuitry': [9, 141], 'that': [10, 24], 'governs': [11], 'ground': [13], 'state': [14, 101], 'of': [15, 27, 39, 49, 88, 110, 135], 'mouse': [16], 'embryonic': [17], '(ESC).': [20], 'Here,': [21], 'we': [22], 'report': [23], 'short-term': [25], 'expression': [26], 'two': [28], 'components,': [29], 'NANOG': [30], 'and': [31, 42, 51, 70, 78, 99, 137], 'KLF2,': [32], 'is': [33, 84, 96, 102], 'sufficient': [34], 'to': [35], 'ignite': [36], 'other': [37], 'elements': [38], 'network': [41], 'reset': [43, 129], 'state.': [47, 59, 130], 'Inhibition': [48], 'ERK': [50, 65], 'protein': [52], 'kinase': [53], 'C': [54], 'sustains': [55], 'a': [56], 'transgene-independent': [57], 'rewired': [58], 'Reset': [60], 'self-renew': [62], 'continuously': [63], 'without': [64], 'signaling,': [66], 'are': [67, 71], 'phenotypically': [68], 'stable,': [69], 'karyotypically': [72], 'intact.': [73], 'They': [74], 'differentiate': [75], 'in': [76, 81, 92, 145], 'vitro': [77], 'form': [79], 'teratomas': [80], 'vivo.': [82], 'Metabolism': [83], 'reprogrammed': [85], 'with': [86], 'activation': [87], 'mitochondrial': [89], 'respiration': [90], 'as': [91], 'ESC.': [93], 'DNA': [94], 'methylation': [95], 'dramatically': [97], 'reduced': [98], 'transcriptome': [100], 'globally': [103], 'realigned': [104], 'across': [105], 'multiple': [106], 'cell': [107], 'lines.': [108], 'Depletion': [109], 'ground-state': [111, 143], 'factors,': [113], 'TFCP2L1': [114], 'or': [115], 'KLF4,': [116], 'has': [117], 'marginal': [118], 'impact': [119], 'on': [120], 'conventional': [121], 'but': [126], 'collapses': [127], 'These': [131], 'findings': [132], 'demonstrate': [133], 'feasibility': [134], 'installing': [136], 'propagating': [138], 'functional': [139], 'control': [140], 'for': [142], 'pluripotency': [144], 'cells.': [147]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2045067641', 'counts_by_year': [{'year': 2024, 'cited_by_count': 58}, {'year': 2023, 'cited_by_count': 76}, {'year': 2022, 'cited_by_count': 85}, {'year': 2021, 'cited_by_count': 81}, {'year': 2020, 'cited_by_count': 91}, {'year': 2019, 'cited_by_count': 93}, {'year': 2018, 'cited_by_count': 90}, {'year': 2017, 'cited_by_count': 99}, {'year': 2016, 'cited_by_count': 83}, {'year': 2015, 'cited_by_count': 94}, {'year': 2014, 'cited_by_count': 10}], 'updated_date': '2024-12-24T22:52:00.147612', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
