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4829, 4881, 4888, 5059, 5139, 5203, 5321], 'nitric': [7, 199, 385, 867], 'oxide': [8, 200, 386, 868], '(NO)-dependent': [9, 201, 869], 'pathway.': [10, 202, 3276, 4171], 'However,': [11, 34, 203, 226, 1059, 4769, 5063], 'mechanisms': [12, 204], 'underlying': [13, 205, 4279], 'IL-6-induced': [14, 64, 206, 256, 946, 1638, 1796, 1861, 3029, 3073, 3162, 3266, 3541, 3568, 3686, 3723, 3769, 3809, 3842, 3867, 4023, 4098, 4156, 4280, 4336, 4650, 4663, 4705, 4729, 4793, 4990, 5005, 5025, 5067, 5265, 5432], 'NO': [15, 65, 149, 207, 257, 341, 1832, 2309, 3724, 3812, 3847, 3870, 3917, 4326, 4341, 4826, 5011, 5036, 5246, 5440], 'production': [16, 66, 208, 258, 1833, 2310, 3570, 3690, 3725, 3813, 3848, 3918, 4327, 4827, 5037], 'remain': [17, 209], 'unclear.': [18, 210, 1800, 5077], 'JAK2/STAT3': [19, 178, 184, 211, 370, 376, 1082, 1812, 2852, 3274, 3855, 4015, 4296, 4678, 4699, 5026, 5285, 5411, 5429, 5450], 'and': [20, 59, 67, 82, 94, 114, 134, 151, 166, 179, 212, 251, 259, 274, 286, 306, 326, 343, 358, 371, 395, 433, 472, 512, 515, 767, 801, 909, 951, 1010, 1030, 1068, 1116, 1188, 1293, 1522, 1528, 1584, 1637, 1688, 1793, 1813, 1828, 1865, 1927, 1958, 1971, 1996, 2036, 2065, 2080, 2141, 2152, 2213, 2243, 2293, 2301, 2317, 2323, 2331, 2338, 2347, 2366, 2400, 2424, 2467, 2502, 2563, 2624, 2731, 2749, 2809, 2884, 2911, 2926, 2944, 2949, 3044, 3067, 3112, 3135, 3172, 3182, 3202, 3252, 3371, 3580, 3627, 3646, 3691, 3715, 3755, 3818, 3846, 3987, 4034, 4041, 4052, 4066, 4079, 4089, 4102, 4110, 4141, 4176, 4297, 4331, 4334, 4343, 4358, 4376, 4382, 4504, 4506, 4533, 4627, 4634, 4679, 4696, 4709, 4800, 4828, 4894, 5002, 5013, 5038, 5143, 5188, 5207, 5326, 5377, 5396, 5412, 5442, 5484], 'ERK1/2': [21, 83, 123, 129, 180, 213, 275, 315, 321, 372, 1118, 1656, 1691, 1750, 1792, 1814, 3061, 3219, 3269, 3860, 4017, 4298, 4369, 4628, 4658, 4666, 4680, 4708, 5043, 5070, 5083, 5129, 5199, 5208, 5268, 5278, 5306, 5395, 5413], 'are': [22, 214, 3720, 3849, 4019, 4347, 4638, 5018, 5415], 'two': [23, 54, 215, 246], 'well': [24, 216, 3145, 3462], 'known': [25, 217, 3463], 'signaling': [26, 185, 218, 377, 1061, 1439, 1486, 2779, 2987, 3220, 3275, 4179, 5027, 5209, 5286, 5451], 'pathways': [27, 37, 55, 219, 229, 247, 1815, 4018, 4299, 4681, 5414], 'activated': [28, 175, 220, 367, 1658, 1809, 5416], 'by': [29, 107, 132, 164, 221, 299, 324, 356, 427, 1063, 1449, 1499, 1659, 1871, 1875, 1954, 2313, 2533, 2692, 2762, 2786, 3037, 3045, 3056, 3115, 3121, 3248, 3258, 3453, 3574, 3650, 3749, 3816, 3822, 3851, 3983, 4081, 4106, 4116, 4163, 4246, 4322, 4349, 4366, 4427, 4453, 4640, 4690, 4718, 4822, 4910, 4947, 5058, 5085, 5196, 5200, 5252, 5257, 5320, 5368, 5418], 'IL-6': [30, 57, 75, 140, 174, 222, 249, 267, 332, 366, 463, 511, 834, 862, 896, 999, 1025, 1065, 1074, 1194, 1632, 1808, 1841, 1846, 1937, 2343, 2708, 2839, 2849, 2983, 3027, 3216, 3236, 3286, 3352, 3447, 3520, 3564, 3630, 3662, 3745, 3782, 3898, 3974, 4043, 4076, 4147, 4211, 4292, 4309, 4375, 4454, 4620, 4675, 4770, 4815, 5253, 5294, 5382, 5419], 'in': [31, 42, 63, 69, 190, 223, 234, 255, 261, 382, 507, 518, 524, 843, 853, 1126, 1186, 1299, 1376, 1421, 1444, 1488, 1625, 1647, 1736, 1795, 1816, 1831, 1867, 2005, 2186, 2228, 2258, 2281, 2297, 2320, 2329, 2335, 2379, 2464, 2544, 2841, 2854, 2976, 2988, 3089, 3131, 3221, 3240, 3288, 3330, 3341, 3347, 3353, 3393, 3411, 3420, 3437, 3467, 3512, 3540, 3552, 3604, 3608, 3634, 3667, 3688, 3705, 3776, 3788, 3811, 3828, 3869, 3919, 3934, 3977, 3985, 4021, 4036, 4063, 4100, 4158, 4188, 4300, 4325, 4328, 4340, 4345, 4629, 4692, 4720, 4734, 4796, 4825, 4831, 4950, 5053, 5069, 5072, 5089, 5133, 5185, 5210, 5269, 5283, 5295, 5328, 5404, 5420, 5434, 5439, 5444, 5460], 'non-cardiac': [32, 224, 1127], 'cells.': [33, 225], 'these': [35, 53, 227, 245, 847, 3024, 3513, 3516], 'IL-6-activated': [36, 228, 5449], 'have': [38, 230, 521, 1191, 1617, 1642, 1652, 4181], 'not': [39, 120, 137, 169, 231, 312, 329, 361, 1643, 1874, 3055, 3206, 3257, 3327, 3648, 3821, 3836, 3858, 3930, 4115, 4149, 4169, 4283, 4365, 4655, 4668, 4702, 4724, 5255, 5281], 'been': [40, 232, 522, 836, 1076, 1381, 1492, 1618, 1644, 2617, 2781, 3328, 4182, 4284, 4547, 4942, 5046, 5308], 'identified': [41, 50, 233, 242], 'adult': [43, 72, 235, 264, 1626, 1817, 1885, 2855, 2989, 3132, 3222, 3331, 3354, 3978, 4215, 4301, 4693, 4797, 4951, 5296, 5329, 5421], 'myocytes.': [45, 74, 237, 266, 1819, 1854, 2843, 2857, 2992, 3225, 3333, 3357, 4303, 5298, 5424], 'In': [46, 238, 850, 995, 1480, 1730, 1801, 2737, 3758, 4286, 4613, 4642, 4994, 5126, 5236, 5299, 5407], 'this': [47, 239, 1802, 2836, 3106, 3685, 4287], 'study,': [48, 240, 998, 1803, 4288, 4616, 4997], 'we': [49, 241, 1804, 1857, 2845, 4011, 4289, 4617, 4998], 'activation': [51, 243, 959, 1203, 1482, 1634, 1692, 1751, 1790, 1862, 2776, 3852, 4164, 4651, 4664, 4706, 4902, 4949, 4987, 5081, 5130, 5266, 5279, 5304, 5364, 5387, 5427], 'of': [52, 71, 78, 103, 128, 145, 158, 244, 263, 270, 295, 320, 337, 350, 397, 423, 510, 846, 912, 948, 960, 1024, 1197, 1204, 1296, 1374, 1391, 1456, 1483, 1503, 1615, 1622, 1635, 1749, 1788, 1791, 1826, 1840, 1852, 1863, 1884, 1941, 1945, 1964, 2042, 2054, 2340, 2382, 2387, 2462, 2481, 2512, 2528, 2687, 2699, 2768, 2777, 2835, 2863, 2872, 2896, 2903, 2929, 2936, 2947, 2998, 3006, 3011, 3031, 3076, 3091, 3100, 3139, 3164, 3168, 3185, 3196, 3233, 3242, 3268, 3272, 3285, 3322, 3324, 3374, 3406, 3426, 3446, 3465, 3528, 3583, 3611, 3617, 3661, 3673, 3680, 3718, 3801, 3853, 3863, 3905, 4032, 4050, 4057, 4144, 4165, 4214, 4351, 4368, 4386, 4388, 4397, 4419, 4496, 4508, 4530, 4543, 4624, 4652, 4665, 4686, 4707, 4715, 4792, 4806, 4814, 4843, 4891, 4903, 5032, 5061, 5066, 5082, 5198, 5259, 5264, 5267, 5293, 5305, 5316, 5324, 5365, 5375, 5388, 5428, 5481], 'during': [56, 248, 419, 871, 1526, 2970, 3628, 3726, 4223, 4840], 'stimulation': [58, 250, 2535, 2785, 2840, 2973, 3287], 'examined': [60, 252, 2303, 2847, 3329, 4012, 4788], 'their': [61, 253], 'roles': [62, 254, 4187], 'decrease': [68, 189, 260, 381, 901, 1866, 4157, 4344, 4830, 5443], 'ventricular': [73, 265, 1395, 1818, 1853, 1878, 2529, 2856, 2991, 3133, 3224, 3356, 3979, 4217, 4302, 4694, 4798, 4953, 5297, 5331, 5423], 'increased': [76, 148, 268, 340, 2907, 3367, 3397, 3556, 3671, 3783, 4657, 4774, 4818], 'phosphorylation': [77, 127, 269, 319, 2862, 2902, 2937, 3005, 3030, 3075, 3090, 3163, 3198, 3241, 3267, 4353, 4424, 4529, 4623, 4685, 5071], 'STAT3': [79, 104, 271, 296, 1288, 1433, 1744, 1761, 2864, 2964, 2986, 3007, 3032, 3077, 4352, 4509, 4531, 4626, 4653, 4986, 5006, 5141, 5145, 5153, 5405], '(at': [80, 84, 272, 276], 'Tyr705)': [81, 273], 'Tyr204)': [85, 277], 'within': [86, 278, 916, 2887, 3525, 4318, 4811], '5': [87, 279, 2870, 3098, 3335, 3379, 3413], 'min': [88, 93, 280, 285, 2227, 2247, 2273, 2280, 2420, 2871, 2928, 3010, 3022, 3099, 3111, 3184, 3232, 3624, 3892], 'that': [89, 173, 281, 365, 861, 1014, 1193, 1386, 1436, 1655, 1689, 1807, 1823, 1859, 2698, 2861, 2982, 3072, 3086, 3125, 3215, 3229, 3265, 3389, 3416, 3519, 3548, 3566, 3620, 3656, 3711, 3732, 3781, 3841, 3933, 3973, 4056, 4154, 4210, 4291, 4307, 4619, 4635, 4673, 4802, 4887, 4985, 5000, 5023, 5182, 5242, 5277], 'peaked': [90, 282, 3108], 'at': [91, 99, 283, 291, 1961, 2087, 2129, 2191, 2264, 2353, 2368, 2402, 2414, 2421, 2441, 2453, 2541, 2865, 2881, 2957, 3033, 3093, 3109, 3199, 3244, 3362], '15–30': [92, 284], 'returned': [95, 287, 2938], 'to': [96, 288, 460, 838, 900, 956, 1002, 1078, 1290, 1301, 2391, 2489, 2518, 2607, 2619, 2697, 2745, 2838, 2874, 2931, 2939, 3013, 3102, 3118, 3235, 3349, 3428, 3561, 3626, 3742, 3895, 3912, 3944, 3990, 4055, 4073, 4146, 4184, 4379, 4489, 4510, 4538, 4549, 4845, 4944, 5048, 5301, 5310, 5313], 'basal': [97, 289, 2940, 3119, 3137, 3697], 'levels': [98, 290, 509, 2941, 2966, 3120, 4771], '2': [100, 156, 292, 348, 1838, 2016, 2019, 2022, 2029, 2943, 2994, 3122, 3404, 3424, 3526, 3678, 3738, 3799, 3900, 4071, 4319, 4812], 'h.': [101, 293, 2889, 3123, 3901], 'Phosphorylation': [102, 294], 'was': [105, 130, 297, 322, 897, 954, 1000, 1012, 1947, 2045, 2311, 2364, 2389, 2398, 2412, 2428, 2470, 2531, 2567, 2605, 2665, 2690, 2709, 2723, 2760, 2867, 2906, 2955, 3035, 3095, 3113, 3205, 3246, 3280, 3360, 3366, 3396, 3418, 3434, 3506, 3555, 3571, 3606, 3621, 3639, 3647, 3670, 3746, 3814, 4732, 4809, 4908, 5131, 5194, 5254], 'blocked': [106, 131, 163, 298, 323, 355, 3036, 3247, 3572, 3684, 3747, 3815, 4105, 4348, 4639, 4648, 4662, 4689, 4909], 'genistein,': [108, 300, 2729, 3048], 'protein': [110, 302, 474, 516, 1824, 2044, 2056, 2393, 2965, 3050, 3343, 3359, 3391, 3523, 3536, 3543, 3618, 3645, 3735, 3844, 4312, 4360, 4553, 4808, 4992, 5009, 5436], 'tyrosine': [111, 303, 3051, 3074, 4361, 4423, 4622, 4684], 'kinase': [112, 124, 304, 316, 392, 401, 3001, 3052, 3062, 3864, 3923, 4362, 4554], 'inhibitor,': [113, 118, 305, 310, 3043, 3053], 'AG490,': [115, 307, 3040, 3885, 4123], 'JAK2': [117, 309, 1205, 3042, 3081, 4356, 4645, 5397, 5401], 'but': [119, 136, 168, 182, 311, 328, 360, 374, 1873, 3054, 3256, 3365, 3820, 3857, 4114, 4168, 4364, 4654, 4667], 'PD98059,': [121, 313, 2730, 3059, 3882, 4122, 5201], 'an': [122, 314, 840, 1829, 2305, 2570, 3060, 3087, 3615, 4042, 4220, 4323, 4823, 5050], 'inhibitor.': [125, 317], 'The': [126, 318, 944, 1372, 1943, 2040, 2147, 2360, 2375, 2395, 2409, 2460, 2602, 2684, 2934, 3194, 3449, 3632, 3916, 4048, 4097, 4134, 4277, 4712, 4785, 4848, 5042, 5177, 5386], 'PD98059': [133, 325, 3251, 3764], 'genistein': [135, 165, 327, 357, 3255, 3819, 3889, 4113, 4125, 5001], 'AG490.': [138, 330, 3261], 'Furthermore,': [139, 331], 'enhanced': [141, 333, 1016, 2136], 'de': [142, 334, 3534, 3712, 4315, 4803], 'novo': [143, 335, 3535, 4316, 4804], 'synthesis': [144, 336, 475, 3537, 3619, 3714, 4317, 4805], 'iNOS': [146, 338, 1004, 1017, 1067, 1827, 1864, 3278, 3325, 3342, 3358, 3390, 3417, 3450, 3466, 3522, 3542, 3719, 3734, 3770, 3843, 4221, 4281, 4311, 4337, 4716, 4730, 4794, 4807, 4819, 4849, 4899, 4938, 4991, 5008, 5244, 5317, 5435], 'protein,': [147, 339], 'production,': [150, 342, 4342, 5012, 5247, 5441], 'decreased': [152, 344, 1848, 3975], 'after': [155, 347, 1006, 1837, 2671, 2869, 2922, 2942, 3008, 3097, 3178, 3230, 3282, 3368, 3403, 3423, 3443, 3557, 3677, 3740, 3798, 3831, 4139, 4739, 4779], 'h': [157, 349, 1839, 2086, 2349, 2946, 2959, 3204, 3284, 3364, 3373, 3405, 3425, 3445, 3527, 3679, 3739, 3800, 3928, 4072, 4143, 4813, 4842], 'incubation.': [159, 351, 3681], 'These': [160, 352, 2448, 2979, 3069, 3212, 3262, 3708, 3838, 4151, 4670, 4834, 5016], 'effects': [161, 353, 466, 1621, 1798, 2997, 4837], 'were': [162, 354, 1834, 1869, 1880, 1913, 1931, 1973, 2003, 2058, 2091, 2133, 2149, 2175, 2201, 2222, 2276, 2327, 2377, 2451, 2495, 2515, 2733, 2743, 2828, 3018, 3774, 3826, 3874, 3908, 4104, 4137, 4838], 'AG490': [167, 359, 2732, 3754, 3817, 4109, 4911, 5003], 'PD98059.': [170, 362, 3823, 4119], 'We': [171, 363, 1820, 3530, 4304, 5475], 'conclude': [172, 364], 'independently': [176, 368, 4682], 'the': [177, 187, 369, 379, 420, 424, 768, 844, 996, 1015, 1021, 1027, 1060, 1081, 1117, 1291, 1437, 1446, 1484, 1495, 1690, 1747, 1785, 1811, 1849, 1860, 1955, 1962, 2336, 2372, 2425, 2457, 2490, 2523, 2549, 2668, 2703, 2718, 2851, 2897, 2901, 2971, 2996, 3004, 3128, 3136, 3237, 3273, 3319, 3338, 3567, 3609, 3629, 3635, 3658, 3664, 3674, 3696, 3716, 3733, 3784, 3854, 3859, 3988, 4014, 4022, 4155, 4166, 4177, 4295, 4384, 4400, 4497, 4551, 4614, 4656, 4677, 4698, 4789, 4846, 4904, 4995, 5021, 5024, 5054, 5064, 5238, 5243, 5262, 5284, 5289, 5314, 5373, 5410, 5426, 5431, 5448, 5456, 5477], 'pathways,': [181, 373], 'only': [183, 375, 1735, 4649, 5148, 5400], 'mediated': [186, 378, 1870, 3079, 3850, 4162], 'NO-associated': [188, 380], 'contractility.': [191, 383, 5041, 5446], 'interleukin': [384], 'nitric-oxide': [387], 'synthase': [388], 'inducible': [389], 'NOS': [390], 'Janus': [391], 'signal': [393, 1123, 2604, 4391], 'transducer': [394], 'activator': [396], 'transcription': [398, 1200], 'extracellular': [399, 3991], 'signal-regulated': [400], 'cell': [402, 769, 910, 1031, 2324, 2449, 2468, 2509, 3644, 3668, 3703, 3706, 3789, 3829, 4332, 4884], 'shortening': [403], 'post-rest': [404], 'potentiation': [405, 2613], 'leukemia': [406, 1450], 'inhibitory': [407, 1451], 'factor': [408, 1452, 5191], 'interferon-γ': [409], 'phosphate-buffered': [410], 'saline': [411], 'cycloheximide': [412], 'IL-6,1': [413], 'pro-inflammatory': [415], 'cytokine,': [416], 'is': [417, 1018, 1657, 1693, 3078, 3127, 3270, 3538, 4061, 4161, 4487, 4701, 4723, 4820, 4983, 5075, 5275, 5280, 5402], 'produced': [418], 'acute': [421, 945, 1585, 5467], 'phase': [422], 'immune': [425], 'response': [426, 1300, 3348], 'macrophages,': [428], 'T': [429], 'cells,': [430, 432, 4880], 'B': [431, 2892, 3155], 'non-immune': [434], 'cells': [435, 439, 1128, 1190, 1757, 1912, 2200, 2275, 3292, 4738, 5149], 'such': [436, 4373, 4500, 4781, 5465], 'as': [437, 1893, 1976, 2504, 2578, 2667, 2751, 3144, 3146, 3508, 3910, 3981, 4374, 4425, 4501, 4782, 5466], 'endothelial': [438, 966], '(1Akira': [440, 476], 'S.': [441, 477, 564, 805, 929, 980, 1044, 1087, 1132, 1410, 1566, 1589, 1711, 1717, 1897, 3304, 4262, 4406, 4476, 4515, 4594, 4600, 4754, 5107, 5113], 'Hirano': [442, 478, 1103, 1331], 'T.': [443, 445, 447, 479, 481, 483, 684, 686, 781, 921, 927, 933, 972, 978, 984, 1036, 1042, 1048, 1085, 1091, 1104, 1130, 1136, 1162, 1262, 1304, 1324, 1332, 1358, 1402, 1404, 1470, 1509, 1556, 1599, 1678, 1707, 1709, 1713, 1774, 2799, 2814, 3296, 3302, 3308, 3493, 4254, 4260, 4266, 4404, 4410, 4442, 4468, 4470, 4513, 4519, 4571, 4590, 4592, 4596, 4746, 4752, 4758, 4915, 5103, 5105, 5109, 5167, 5226], 'Taga': [444, 480, 1090, 1135, 1403, 4409, 4467, 4518], 'Kishimoto': [446, 482, 1401, 1469, 1508, 1598, 1677, 1773, 2798, 2813, 4441, 4469, 4570, 5166, 5225], 'FASEB': [448, 484], 'J.': [449, 485, 549, 574, 588, 602, 633, 689, 713, 750, 784, 816, 1105, 1154, 1167, 1216, 1243, 1271, 1333, 1511, 1568, 1569, 1703, 1719, 1901, 1982, 1984, 2588, 2590, 2655, 2816, 3494, 3591, 4000, 4232, 4586, 4602, 4865, 4927, 4965, 5099, 5115, 5343], '1990;': [450, 486, 759], '4:': [451, 487], '2860-2867Crossref': [452, 488], 'PubMed': [453, 489, 500, 554, 580, 612, 638, 668, 699, 738, 762, 796, 828, 891, 939, 990, 1054, 1096, 1111, 1141, 1178, 1252, 1282, 1312, 1339, 1352, 1367, 1415, 1475, 1517, 1548, 1579, 1607, 1683, 1727, 1779, 1908, 2597, 2643, 2662, 2804, 2822, 3314, 3503, 4201, 4272, 4415, 4447, 4481, 4524, 4576, 4610, 4764, 4871, 4932, 4976, 5123, 5172, 5231, 5354], 'Scopus': [454, 490, 501, 555, 581, 613, 639, 700, 739, 763, 797, 829, 892, 940, 991, 1055, 1112, 1179, 1253, 1283, 1313, 1340, 1353, 1368, 1416, 1476, 1518, 1549, 1580, 1608, 1684, 1780, 2598, 2644, 2805, 2823, 3315, 4202, 4273, 4448, 4482, 4577, 4765, 4872, 4933, 4977, 5173, 5232, 5355], '(1159)': [455, 491], 'Google': [456, 492, 503, 557, 583, 615, 641, 669, 702, 718, 741, 765, 799, 831, 894, 942, 993, 1057, 1097, 1114, 1142, 1159, 1181, 1221, 1255, 1285, 1315, 1342, 1355, 1370, 1418, 1478, 1520, 1551, 1582, 1610, 1686, 1728, 1782, 1909, 1992, 2600, 2646, 2663, 2807, 2825, 3317, 3504, 4204, 4275, 4416, 4450, 4484, 4525, 4579, 4611, 4767, 4874, 4935, 4979, 5124, 5175, 5234, 5357], 'Scholar).': [457, 504, 832, 895, 943, 994, 1058, 1182, 1286, 1371, 1419, 1479, 1611, 1729, 1783, 1910, 1993, 2601, 3600, 4009, 4205, 4276, 4417, 4526, 4612, 4768, 4875, 4936, 4980, 5125, 5176, 5235, 5358], 'After': [458, 2070, 2194, 2267, 2522], 'binding': [459, 4858], 'its': [461, 513, 2694, 4535, 5030], 'receptor,': [462, 1125, 4393], 'elicits': [464], 'numerous': [465], 'including': [467, 530], 'antibody': [468], 'induction,': [469], 'hematopoiesis,': [470], 'thrombocytopoiesis,': [471], 'acute-phase': [473], 'Scholar,': [493, 558, 584, 703, 719, 1098, 1143, 1160, 1222, 1256, 1316, 1343, 1356, 2647, 4580], '2Kammuller': [494], 'M.E.': [495], 'Toxicology.': [496], '1995;': [497, 715, 735, 1093, 1138, 1412, 1905, 4412, 4521], '105:': [498], '91-107Crossref': [499], '(23)': [502], 'Significant': [505], 'increases': [506, 3167, 5068], 'serum': [508, 2233, 2263, 2296], 'mRNA': [514, 5192], 'expression': [517, 1005, 1295, 1825, 3279, 3346, 3392, 3451, 3524, 3736, 3845, 4313, 4731, 4795, 4900, 4939, 5193, 5318], 'tissues': [520], 'reported': [523, 2503, 4245], 'patients': [525], 'with': [526, 772, 1389, 1427, 1494, 1523, 1620, 1695, 1741, 1746, 1759, 1845, 1934, 2072, 2093, 2143, 2154, 2196, 2204, 2207, 2215, 2241, 2248, 2270, 2477, 2770, 2783, 2919, 3023, 3166, 3175, 3376, 3400, 3457, 3751, 3761, 3805, 3879, 3922, 3952, 3958, 4121, 4243, 4354, 4399, 4494, 5020, 5138, 5151, 5393], 'several': [527], 'diseases': [529], 'congestive': [531], 'heart': [532, 859, 1490, 3291, 4737], 'failure': [533], '(3Satoh': [534, 618], 'M.': [535, 566, 592, 598, 619, 707, 725, 731, 746, 811, 1089, 1100, 1134, 1147, 1209, 1258, 1322, 1326, 1330, 1362, 1533, 1537, 1558, 1595, 1705, 1715, 3481, 4408, 4456, 4458, 4460, 4466, 4517, 4588, 4598, 5101, 5111], 'Tamura': [536, 620], 'G.': [537, 568, 600, 621, 727, 1145, 1151, 1207, 1213, 4917], 'Segawa': [538, 622], 'I.': [539, 623, 705, 723, 4919], 'Tashiro': [540, 624], 'A.': [541, 625, 733, 925, 976, 1040, 1411, 3300, 4258, 4477, 4750, 5486], 'Hiramori': [542, 626], 'K.': [543, 627, 680, 688, 779, 919, 970, 1034, 1102, 1260, 1320, 1328, 1360, 1400, 1460, 1468, 1507, 1564, 1591, 1601, 1666, 1676, 1701, 1764, 1772, 2789, 2797, 2812, 3294, 4252, 4430, 4440, 4464, 4559, 4569, 4584, 4744, 4956, 5097, 5157, 5165, 5216, 5224, 5334], 'Satodate': [544, 628], 'R.': [545, 629, 748, 1240, 4862], 'Virchows': [546, 630], 'Arch.': [547, 631], 'Int.': [548, 632, 1510, 2815], 'Pathol.': [550, 634, 1513, 2818], '1996;': [551, 577, 635, 820, 1108, 1680, 4444, 4573, 4968, 5346], '427:': [552, 636], '503-509Crossref': [553, 637], '(68)': [556, 640], '4Steele': [559], 'I.C.': [560], 'Nugent': [561], 'A.M.': [562], 'Maguire': [563], 'Hoper': [565], 'Campbell': [567], 'Halliday': [569], 'M.I.': [570], 'Nicholls': [571], 'D.P.': [572], 'Eur.': [573], 'Clin.': [575], 'Invest.': [576], '26:': [578], '1018-1022Crossref': [579], '(50)': [582, 1581], '5Roig': [585], 'E.': [586, 1462, 1531, 1593, 1766, 2634, 2791, 5159, 5218], 'Orus': [587], 'Pare': [589], 'C.': [590, 1270, 1345, 4864], 'Azqueta': [591], 'Filella': [593], 'X.': [594, 1226], 'Perez-Villa': [595], 'F.': [596, 676, 1224, 1232, 1268, 1560, 4921], 'Heras': [597], 'Sanz': [599], 'Am.': [601, 712, 1718, 1900, 1983, 2589, 2654, 4601, 5114], 'Cardiol.': [603, 692, 1572, 3594, 4003, 4235], '1998;': [604, 788, 1472, 1776, 1989, 2640, 2801, 4929, 5169, 5228], '82:': [605], '688-690Abstract': [606], 'Full': [607, 609, 696, 791, 793, 823, 825, 1173, 1175, 1249, 1277, 1279, 1576, 3500, 4971, 4973, 5349, 5351], 'Text': [608, 610, 697, 792, 794, 824, 826, 1174, 1176, 1250, 1278, 1280, 1577, 3501, 4972, 4974, 5350, 5352], 'PDF': [611, 698, 795, 827, 1177, 1251, 1281, 1578, 3502, 4975, 5353], '(84)': [614], 'Scholar),': [616, 642, 670, 742, 766, 1521, 1552, 1583, 2664, 2826, 3318, 3505, 4241, 4485], 'myocarditis': [617], 'septic': [643], 'cardiomyopathy': [644], '(6Hack': [645], 'C.E.': [646], 'De': [647], 'Groot': [648], 'E.R.': [649], 'Felt-Bersma': [650], 'R.J.': [651, 657], 'Nuijens': [652], 'J.H.': [653], 'Strack': [654], 'Van': [655], 'Schijndel': [656], 'Eerenberg-Belmer': [658], 'A.J.': [659, 3487], 'Thijs': [660], 'L.G.': [661], 'Aarden': [662], 'L.A.': [663], 'Blood.': [664, 1092, 1137, 4411, 4520], '1989;': [665], '74:': [666, 1109], '1704-1710Crossref': [667], 'myocardial': [671, 1553, 1586, 5468], 'infarction': [672, 1587], '(7Ikeda': [673], 'U.': [674, 1149, 1211, 1409, 4475, 4925], 'Ohkawa': [675], 'Seino': [677], 'Y.': [678, 682, 775, 931, 982, 1046, 1464, 1539, 1670, 1674, 1768, 2637, 2793, 3306, 4264, 4434, 4438, 4563, 4567, 4756, 5161, 5220], 'Yamamoto': [679], 'Hidaka': [681], 'Kasahara': [683], 'Kawai': [685], 'Shimada': [687], 'Mol.': [690, 1106, 1306, 1570, 3592, 4001, 4233], 'Cell.': [691, 1305, 1571, 3593, 4002, 4234], '1992;': [693, 888], '24:': [694], '579-584Abstract': [695], '(161)': [701], '8Guillen': [704], 'Blanes': [706], 'Gomez-Lechon': [708], 'M.J.': [709], 'Castell': [710], 'J.V.': [711], 'Physiol.': [714, 1720, 1723, 1902, 1904, 1985, 1988, 2591, 2593, 2656, 2658, 4603, 4606, 5116, 5119], '269:': [716, 3498], 'R229-R235PubMed': [717], '9Neumann': [720], 'F.-J.': [721], 'Ott': [722], 'Gawaz': [724], 'Richardt': [726], 'Holzapfel': [728], 'H.': [729, 777, 783, 1398, 1466, 1562, 1597, 1668, 1672, 1699, 1770, 2632, 2795, 4194, 4432, 4436, 4462, 4561, 4565, 4582, 4913, 5095, 5163, 5222], 'Jochum': [730], 'Schömig': [732], 'Circulation.': [734, 1471, 1544, 1679, 1775, 2800, 4443, 4572, 5168, 5227], '92:': [736, 1413], '748-755Crossref': [737], '(466)': [740], 'myxoma': [744], '(10Jourdan': [745], 'Bataille': [747], 'Seguin': [749], 'Zhang': [751], 'X.G.': [752], 'Chaptal': [753], 'P.A.': [754], 'Klein': [755], 'B.': [756], 'Arthritis': [757], 'Rheum.': [758], '33:': [760, 1574], '398-402Crossref': [761], '(143)': [764], 'injury': [770], 'associated': [771, 1493, 1619, 1694, 2782, 5392], 'ischemia/reperfusion': [773], '(11Sawa': [774], 'Ichikawa': [776], 'Kagisaki': [778], 'Ohata': [780], 'Matsuda': [782], 'Thorac.': [785, 817], 'Cardiovasc.': [786, 818, 1602], 'Surg.': [787, 819, 1244], '116:': [789], '511-517Abstract': [790], '(120)': [798], 'Scholar)': [800, 1115, 1687, 2808, 4451], 'cardiopulmonary': [802, 4783, 5473], 'bypass': [803], '(12Wan': [804], 'DeSmet': [806], 'J.M.': [807], 'Barvais': [808], 'L.': [809, 2630], 'Goldstein': [810], 'Vincent': [812], 'J.L.': [813, 815, 4958, 5336], 'LeClerc': [814], '112:': [821], '806-811Abstract': [822], '(234)': [830], 'Thus,': [833, 1784, 2844, 3515, 4010, 5447], 'has': [835, 1075, 1379, 1491, 2616, 2780, 3326, 4282, 4545, 4853, 4940, 5045, 5307], 'suggested': [837, 955, 1013, 1435, 4183, 4209], 'play': [839, 4185, 5049], 'important': [841, 4186, 5051], 'role': [842, 1373, 1443, 1787, 5052, 5065, 5263], 'pathophysiology': [845, 4190], 'disorders.': [849], 'vitro': [851], 'studies': [852, 1185, 4208], 'papillary': [854], 'muscle': [855], 'isolated': [856, 1881], 'from': [857, 958, 1755, 1882, 2497, 2711, 2725, 2735, 3209, 3385, 3876, 3932, 3942, 5363], 'hamster': [858], 'showed': [860, 1385, 1822, 3972, 4306, 4618, 4886, 4999, 5181, 5241], 'pathway': [870, 1083, 1119, 1440, 1487, 2837, 2853, 4180, 4222, 5028, 5044, 5287, 5452], '20-min': [873], 'exposure': [874, 2525, 2873, 2930, 3012, 3101, 3186, 3234, 3427, 3560, 3741, 3802, 3894, 4145, 4225, 4844], '(13Finkel': [875], 'M.S.': [876], 'Oddis': [877], 'C.V.': [878], 'Jacob': [879], 'T.D.': [880], 'Watkins': [881], 'S.C.': [882, 1264], 'Hatttler': [883], 'B.G.': [884], 'Simmons': [885, 3474], 'R.L.': [886], 'Science.': [887], '257:': [889], '387-389Crossref': [890], '(1497)': [893], 'also': [898, 1380, 1653, 1821, 1847, 3149, 4305, 4546, 4941, 4988, 5180], 'shown': [899, 1001, 1077, 1192, 1654, 4062, 4548, 4943, 5047, 5309], 'peak': [902, 2695], 'cytosolic': [903], 'intracellular': [904], 'Ca2+': [905, 1028, 2622, 3992], '([Ca2+]': [906], 'i': [907, 953], ')': [908], 'contraction': [911, 1032, 2527, 2670], 'chick': [913, 3289, 4249, 4735], 'embryonic': [914, 3290, 4736], 'cardiomyocytes': [915, 4250], 'minutes': [917], '(14Kinugawa': [918, 969, 1033, 3293, 4251, 4743], 'Takahashi': [920, 971, 1035, 1706, 3295, 4253, 4589, 4745, 5102], 'Kohmoto': [922, 973, 1037, 3297, 4255, 4747], 'O.': [923, 974, 1038, 3298, 4256, 4748], 'Yao': [924, 975, 1039, 3299, 4257, 4749], 'Aoyagi': [926, 977, 1041, 3301, 4259, 4751], 'Momomura': [928, 979, 1043, 3303, 4261, 4753], 'Hirata': [930, 981, 1045, 3305, 4263, 4755], 'Serizawa': [932, 983, 1047, 3307, 4265, 4757], 'Circ.': [934, 985, 1049, 1722, 1987, 3309, 4267, 4605, 4759, 5118], 'Res.': [935, 986, 1050, 1245, 1348, 1603, 3310, 4268, 4760], '1994;': [936, 987, 1051, 3311, 3497, 4269, 4761], '75:': [937, 988, 1052, 3312, 4270, 4762], '285-295Crossref': [938, 989, 1053, 3313, 4271, 4763], '(168)': [941, 992, 1056, 3316, 4274, 4766], 'suppression': [947], '[Ca2+]': [952], 'result': [957, 5362], 'Ca2+-dependent': [961], 'NOS,': [962], 'presumably': [963], 'constitutive': [965], 'isoform': [967], '(eNOS)': [968], 'same': [997, 3659, 4135, 5178], 'induce': [1003], '24-h': [1008, 2972, 4741], 'incubation,': [1009], 'it': [1011, 3433, 4982, 5274], 'responsible': [1019], 'for': [1020, 1938, 1966, 2084, 2210, 2225, 2245, 2278, 2344, 2357, 2406, 2418, 2445, 2676, 2900, 3020, 3722, 3890, 3899, 3926, 4070, 4492, 4704, 4775, 4856, 5455], 'chronic': [1022, 4224], 'effect': [1023, 3107, 3694, 3767, 4129], 'on': [1026, 2061, 3003, 3695, 3768, 3866, 4130], 'transient': [1029], 'mechanism': [1062, 4278], 'which': [1064, 2388, 2615, 2905, 3381, 4486, 4907], 'activates': [1066, 1294, 2850, 2984, 3218, 4293, 4676, 5379, 5383], 'remains': [1072, 1799, 5272], 'undefined.': [1073], 'activate': [1079, 4550], 'both': [1080, 1810, 4173, 4294, 4625, 4636, 5394, 5409], '(15Kishimoto': [1084, 1129, 4403, 4512], 'Akira': [1086, 1131, 4405, 4514], 'Narazaki': [1088, 1133, 4407, 4457, 4516], '86:': [1094, 1139, 4413, 4522], '1243-1254Crossref': [1095, 1140, 4414, 4523], '16Hibi': [1099], 'Nakajima': [1101, 1319], 'Med.': [1107, 1335, 4867], '1-12Crossref': [1110], '(201)': [1113], 'through': [1120, 2430, 3080], 'gp130,': [1121, 4394], 'transducing': [1124, 4392], '17Schumann': [1144], 'Huell': [1146, 1208], 'Machein': [1148, 1210], 'Hocke': [1150, 1212], 'Fiebich': [1152, 1214], 'B.L.': [1153, 1215], 'Neurochem.': [1155, 1217], '1999;': [1156, 1218, 1309, 1336, 1349], '73:': [1157, 1219], '2009-2017PubMed': [1158, 1220], '18Ueda': [1161], 'Bruchovsky': [1163], 'N.': [1164, 1318, 1535, 2636], 'Sadar': [1165], 'M.D.': [1166], 'Biol.': [1168, 1272, 3495, 4966, 5344], 'Chem.': [1169, 1273, 3496, 4967, 5345], '2002;': [1170], '277:': [1171], '7076-7085Abstract': [1172], '(317)': [1180], 'For': [1183, 4727, 5078, 5371], 'example,': [1184, 4728, 5079, 5372], 'liver': [1187], 'neuronal': [1189], 'induces': [1195, 3521, 4310, 5087], 'Tyr705phosphorylation': [1196], 'STAT3,': [1198, 2904], 'factor,': [1201], '(17Schumann': [1206], '19Debonera': [1223], 'Aldeguer': [1225], 'Shen': [1227], 'X.D.': [1228], 'Gelman': [1229], 'A.E.': [1230], 'Gao': [1231], 'Que': [1233], 'X.Y.': [1234], 'Greenbaum': [1235], 'L.E.': [1236], 'Furth': [1237], 'E.E.': [1238], 'Taub': [1239], 'Olthoff': [1241], 'K.M.': [1242], '2001;': [1246, 1274, 1545, 1573, 4198], '96:': [1247], '289-295Abstract': [1248], '(79)': [1254], '20Niehof': [1257], 'Streetz': [1259], 'Rakemann': [1261], 'Bischoff': [1263], 'Manns': [1265], 'M.P.': [1266], 'Horn': [1267], 'Trautwein': [1269], '276:': [1275], '9016-9027Abstract': [1276], '(91)': [1284], 'Activated': [1287], 'translocates': [1289], 'nucleus': [1292], 'many': [1297, 5461], 'genes': [1298], 'cytokines': [1302, 1458, 1505, 1624, 4175, 4719], '(21Decker': [1303], 'Life': [1307], 'Sci.': [1308, 1408, 2639, 4474], '55:': [1310], '1505-1508Crossref': [1311], '(19)': [1314], '22Kiuchi': [1317], 'Ichiba': [1321], 'Fukada': [1323], 'Narimatsu': [1325], 'Mizuno': [1327], 'Hibi': [1329, 1361, 4459], 'Exp.': [1334, 1346, 1512, 2817, 4866], '189:': [1337], '63-73Crossref': [1338], '(342)': [1341], '23Schindler': [1344], 'Cell': [1347, 1903, 2099, 2592, 2657, 3872], '253:': [1350], '7-14Crossref': [1351], '(116)': [1354], '24Hirano': [1357], 'Ishihara': [1359], 'Oncogene.': [1363], '2000;': [1364, 1514, 1604, 1724, 2819, 3595, 4004, 4236, 4607, 5120], '19:': [1365], '2548-2556Crossref': [1366], '(982)': [1369], 'gp130': [1375, 1392, 4398, 4420, 4511, 4544], 'function': [1378, 1851, 2626, 5074, 5271], 'examined.': [1382], 'One': [1383], 'study': [1384, 4787, 5179, 5240], 'transgenic': [1387], 'mice': [1388], 'overexpression': [1390], 'displayed': [1393, 5154], 'hypertrophied': [1394], 'myocardium': [1396], '(25Hirota': [1397], 'Yoshida': [1399], 'Proc.': [1405, 4471], 'Natl.': [1406, 4472], 'Acad.': [1407, 2638, 4473], '4862-4866Crossref': [1414], '(451)': [1417], 'Studies': [1420, 1646, 4876], 'fetal': [1422, 1737, 5134, 5211], 'murine': [1423, 5212], 'myocytes': [1425, 1651, 1739, 1879, 1998, 2530, 3395, 3441, 3469, 3877, 3920, 3980, 4218, 4722, 4799, 4954, 5093, 5136, 5214, 5332], 'infected': [1426, 1740, 1758, 5137, 5150], 'adenovirus': [1428], 'carrying': [1429], 'wild-type': [1430, 1743, 5140], 'or': [1431, 1917, 2117, 2164, 2499, 2680, 2766, 3442, 3886, 4124, 4132, 4395, 4452, 5248, 5472], 'mutated': [1432, 1760, 5144], 'cDNA': [1434, 1745, 1762, 5142], 'STAT3-dependent': [1438, 5186], 'plays': [1441], 'promoting': [1445], 'hypertrophy': [1447, 1497, 1697, 1733, 5056, 5088, 5155], 'induced': [1448, 3452, 3737, 4426, 4898, 5057, 5084, 5251], '(LIF),': [1453], 'member': [1455, 1502], 'IL-6-related': [1457, 1504, 1623, 4174, 4371], '(26Kunisada': [1459, 1763, 2788, 5156, 5215], 'Tone': [1461, 1592, 1765, 2790, 5158, 5217], 'Fujio': [1463, 1669, 1767, 2792, 4433, 4562, 5160, 5219], 'Matsui': [1465, 1671, 1769, 2794, 4435, 4564, 5162, 5221], 'Yamauchi-Takihara': [1467, 1600, 1675, 1771, 2796, 4439, 4568, 5164, 5223], '98:': [1473, 1777, 2802, 5170, 5229], '346-352Crossref': [1474, 1778, 2803, 5171, 5230], '(204)': [1477, 1781, 2806, 5174, 5233], 'addition,': [1481], 'JAK/STAT': [1485, 1616, 1794, 2778, 4178, 5206], 'rat': [1489, 1627, 1649, 2707, 2990, 3223, 3355, 4216, 4952, 5091, 5330, 5422], 'stimulated': [1498], 'cardiotrophin-1,': [1500], 'another': [1501], '(27Yamauchi-Takihara': [1506, 2811], '81:': [1515, 2820], '1-16Crossref': [1516, 2821], '(60)': [1519, 2824], 'dysfunction': [1525, 5458], 'ischemia': [1527, 1554], 'reperfusion': [1529], '(28Mascareno': [1530], 'El-Shafei': [1532], 'Maulik': [1534], 'Sato': [1536], 'Guo': [1538], 'Das': [1540], 'D.K.': [1541], 'Siddiqui': [1542], 'M.A.Q.': [1543], '104:': [1546], '325-329Crossref': [1547], '(152)': [1550], '(29Omura': [1555], 'Yoshiyama': [1557], 'Ishikura': [1559], 'Kobayashi': [1561], 'Takeuchi': [1563], 'Beppu': [1565], 'Yoshikawa': [1567], '307-316Abstract': [1575], '(30Negoro': [1588], 'Kunisada': [1590], 'Funamoto': [1594], 'Oh': [1596], '47:': [1605], '797-805Crossref': [1606], '(190)': [1609], 'Although': [1612, 2775, 3277, 5261], 'different': [1613, 3000, 3208, 5366, 5369], 'isoforms': [1614], 'heart,': [1628], 'direct': [1629, 2833], 'links': [1630], 'between': [1631, 5205], 'stimulation,': [1633], 'JAK/STAT,': [1636], 'inotropic': [1640, 4025, 5291], 'actions': [1641, 5292], 'established.': [1645], 'neonatal': [1648, 5090], 'LIF': [1660, 2787, 4401, 4428, 5086], 'gp130-dependent': [1663, 5080], 'process': [1664], '(31Kunisada': [1665, 4429, 4558], 'Hirota': [1667, 4431, 4560], 'Tani': [1673, 4437, 4566], '94:': [1681, 4445, 4574], '2626-2632Crossref': [1682, 4446, 4575], '(170)': [1685, 4449, 4578], '(32Kodama': [1698, 5094], 'Fukuda': [1700, 4583, 5096], 'Pan': [1702, 4585, 5098], 'Sano': [1704, 4587, 5100], 'Kato': [1708, 4591, 5104], 'Makino': [1710, 4593, 5106], 'Manabe': [1712, 4595, 5108], 'Murata': [1714, 4597, 5110], 'Ogawa': [1716, 4599, 5112], 'Heart': [1721, 1986, 4195, 4604, 5117], '279:': [1725, 4608, 5121], 'H1635-H1644Crossref': [1726, 4609, 5122], 'contrast,': [1731, 3759, 4643, 5127, 5237], 'LIF-induced': [1732, 5128, 5183], 'occurred': [1734], 'level': [1748, 2935, 3138, 3195, 3698], 'showing': [1752, 3159], 'no': [1753, 2829, 3693, 3766, 4128], 'difference': [1754], 'those': [1756], 'functional': [1786], 'gp130-associated': [1789], 'first': [1805, 1835, 2669, 2846], 'demonstrated': [1806, 3982, 4290], 'increase': [1830, 2952, 3088, 3239, 3340, 3603, 3687, 3810, 3868, 4324, 4339, 4824, 5184, 5433, 5438], 'detectable': [1836, 3436], 'stimulation.': [1842, 3448, 4816], 'Such': [1843, 4817], 'treatment': [1844, 2195], 'contractile': [1850, 2625, 4832], 'Most': [1855], 'importantly,': [1856], 'found': [1858, 4801], 'JAK2/STAT3,': [1872, 4167], 'ERK1/2.': [1876, 5260], 'Single': [1877], 'hearts': [1883], '(3–6-month-old)': [1886], 'male': [1887], 'Sprague-Dawley': [1888], 'rats': [1889], 'using': [1890, 2047, 2135, 2304, 2472, 2569, 4248, 4877], 'enzymatic': [1891], 'dissociation': [1892], 'described': [1894, 1977, 2579], 'previously': [1895, 1978, 2580], '(33Liu': [1896], 'Schreur': [1898], 'K.D.': [1899], '268:': [1906], 'C339-C349Crossref': [1907], 'Isolated': [1911], 'plated': [1914, 2176], 'into': [1915], 'Petri': [1916], 'culture': [1918, 1925, 2188, 2321, 2333, 2465, 3553, 4329], 'dishes': [1919], '(Falcon)': [1920], 'containing': [1921, 2009, 2076, 2217, 2230, 2260, 2283, 2548], 'serum-free,': [1923], 'l-arginine-containing': [1924], 'medium': [1926, 2334, 3554, 4330], 'incubated': [1928, 2224, 2244, 2277, 2328], 'overnight.': [1929], 'Myocytes': [1930, 2174, 2326], 'then': [1932, 2150, 2223, 2302, 2516, 2885, 3531], 'treated': [1933, 1997, 2513, 2741, 3906, 3921, 4044], '10': [1935, 2025, 2037, 2197, 2211, 2341, 2358, 2561, 2875, 3014, 3046, 3057, 3103, 3249, 3253, 3350, 3429, 3458, 3562, 3612, 3743, 3756, 3762, 3880, 3887, 3896, 4074, 4111, 4117], 'ng/ml': [1936, 2198, 2342, 2876, 3015, 3104, 3351, 3430, 3459, 3563, 3744, 3897, 4075], 'various': [1939], 'periods': [1940, 4778], 'time.': [1942], 'use': [1944], 'animals': [1946], 'carried': [1948, 1974], 'out': [1949, 1975], 'under': [1950, 3657], 'protocol': [1952], 'approved': [1953], 'Animal': [1956], 'Care': [1957], 'Use': [1959], 'Committee': [1960], 'University': [1963], 'Arkansas': [1965], 'Medical': [1967], 'Sciences.': [1968], 'Protein': [1969], 'preparation': [1970], 'immunoblotting': [1972], '(34Liu': [1979], 'S.J.': [1980, 2582, 3590, 3999, 4231], 'McHowat': [1981], '44:': [1990], 'H1462-H1472Crossref': [1991], 'Briefly,': [1994], 'control': [1995, 2748, 3440, 3511, 3638, 3676, 3914], '(0.25': [1999], '×': [2000, 2355, 2404, 2416, 2443], '106': [2001], 'cells/group)': [2002], 'lysed': [2004], 'ice-cold': [2006], 'lysis': [2007], 'buffer': [2008, 2074], '20': [2010, 2033, 2079, 2226, 2407, 3038, 3259, 3752, 3883, 4107], 'mm': [2011, 2014, 2017, 2020, 2023, 2026, 2030], 'HEPES,': [2012], '250': [2013], 'sucrose,': [2015], 'dithiothreitol,': [2018], 'EDTA,': [2021], 'EGTA,': [2024], 'sodium': [2027], 'orthovanadate,': [2028], 'phenylmethylsulfonyl': [2031], 'fluoride,': [2032], 'μg/ml': [2034, 2038], 'leupeptin,': [2035], 'aprotinin.': [2039], 'concentration': [2041, 2461, 3551, 3666, 3787], 'total': [2043, 2315, 3549, 3785], 'determined': [2046, 2471, 3532], 'Bradford': [2049], 'assay': [2050, 2475, 2721], '(Bio-Rad).': [2051, 2146], '20–40': [2052], 'μg': [2053], 'each': [2055, 2519, 2746, 3913], 'sample': [2057], 'separated': [2059], 'electrophoretically': [2060], '10%': [2062, 2231], 'SDS-polyacrylamide': [2063], 'gels': [2064], 'electrotransferred': [2066], 'onto': [2067, 2177], 'nitrocellulose': [2068], 'membranes.': [2069], 'blocking': [2071], 'Tris': [2073], 'solution': [2075, 2547], '0.05%': [2077], 'Tween': [2078], '5%': [2081], 'non-fat': [2082], 'milk': [2083], '1': [2085, 2557, 2859, 2888, 2891, 2961, 3363, 3444], 'room': [2088, 2265], 'temperature,': [2089], 'membranes': [2090, 2148], 'probed': [2092], 'polyclonal': [2094, 2118, 2155, 2165, 2249], 'anti-phospho-STAT3': [2095], 'antibodies': [2096, 2107, 2120, 2157, 2167, 2251], '(1:1000': [2097], 'dilution;': [2098, 2109, 2122, 2159, 2169], 'Signaling': [2100], 'Technology': [2101], 'Inc.,': [2102, 2113], 'Beverly,': [2103], 'MA),': [2104], 'monoclonal': [2105], 'anti-phospho-ERK': [2106], '(1:1,000': [2108, 2121], 'Santa': [2110, 2114, 2160, 2170], 'Cruz': [2111, 2161, 2171], 'Biotechnology,': [2112, 2162, 2172], 'Cruz,': [2115], 'CA),': [2116], 'anti-iNOS': [2119, 2250], 'Cayman': [2123, 2253, 2726], 'Co.,': [2124, 2254, 2484], 'Ann': [2125, 2255, 2485], 'Arbor,': [2126, 2256, 2486], 'MI)': [2127, 2257, 2487], 'overnight': [2128, 2190], '4': [2130, 2422, 2945, 3227, 4140], '°C.': [2131, 2193], 'Immunoblots': [2132], 'detected': [2134, 2868, 3096, 3281, 4733, 4810], 'chemiluminescent': [2137], 'kits': [2138], '(SuperSignal;': [2139], 'Pierce)': [2140], 'analyzed': [2142], 'densitometer': [2145], 'stripped': [2151], 'reprobed': [2153], 'anti-STAT3': [2156], '(1:2,000': [2158, 2168], 'Inc.)': [2163], 'anti-ERK': [2166], 'Inc.).': [2173], 'sterile': [2178], 'multi-chamber': [2179], 'slides': [2180], '(Nalge': [2181], 'Nunc': [2182], 'Corp.,': [2183], 'Naperville,': [2184], 'IL)': [2185], 'serum-free': [2187, 2330], 'media': [2189, 2322, 2466], '37': [2192], 'IL-6,': [2199, 2877, 2932, 3431], 'washed': [2202, 2240], 'twice': [2203], 'PBS,': [2205, 2242], 'fixed': [2206], '4%': [2208], 'paraformaldehyde': [2209], 'min,': [2212, 2883], 'permeabilized': [2214], 'PBS': [2216, 2229, 2259, 2271, 2282, 2383], '0.1%': [2218], 'Triton': [2219], 'X-100.': [2220], 'Cells': [2221, 3017], 'goat': [2232, 2262, 2286, 2295], '(Jackson': [2234], 'ImmunoResearch': [2235, 2291], 'Laboratories,': [2236], 'West': [2237], 'Grove,': [2238], 'PA),': [2239], '60': [2246, 2681, 2927, 3183], '(1:100;': [2252, 2289], '1.5%': [2261, 2294], 'temperature.': [2266], 'three': [2268, 2999, 3943, 4854], 'washes': [2269], '(5': [2272], 'each),': [2274], '45': [2279], 'fluorescein': [2284], 'isothiocyanate-conjugated': [2285], 'anti-rabbit': [2287], 'IgG': [2288], 'Jackson': [2290], 'Laboratories)': [2292], 'dark': [2299], 'chamber': [2300], 'epifluorescent': [2306], 'microscope': [2307], '(Zeiss).': [2308], 'assessed': [2312], 'measuring': [2314], 'nitrate': [2316], 'nitrite': [2318], '(NOx)': [2319], 'lysates.': [2325], 'phenol-red-free': [2332], 'absence': [2337], 'presence': [2339, 3610], '2,': [2345, 3065, 3200, 3369], '4,': [2346, 3201, 3370], '24': [2348, 2958, 3203, 3283, 3372, 4142, 4841], 'before': [2350, 2702, 3026, 3893], 'being': [2351], 'centrifuged': [2352, 2401, 2413], '100': [2354], 'g': [2356, 2405, 2417, 2444], 'min.': [2359, 2408, 2447], 'supernatant': [2361, 2411, 2427], '(culture': [2362], 'media)': [2363], 'removed': [2365], 'kept': [2367, 2452], '−20': [2369, 2454], '°C': [2370, 2455], 'until': [2371, 2456], 'NOx': [2373, 2458, 2463, 2506, 3550, 3569, 3665, 3689, 3786, 3903], 'assay.': [2374, 2459], 'pellets': [2376], 'resuspended': [2378], '500': [2380], 'μl': [2381], '(pH': [2384], '7.4),': [2385], 'half': [2386, 2397], 'used': [2390, 2618, 3507], 'determine': [2392, 2608], 'content.': [2394], 'other': [2396], 'sonicated': [2399], '10,000': [2403], 'resulting': [2410], '100,000': [2415], '15': [2419, 2882], '°C,': [2423], 'final': [2426], 'filtered': [2429], '10-kDa': [2432], 'molecular': [2433], 'mass': [2434], 'cut-off': [2435], 'filter': [2436], '(Fisher': [2437], 'Scientific,': [2438], 'Pittsburgh,': [2439], 'PA)': [2440], '12,000': [2442], '30': [2446, 2677, 3009, 3021, 3110, 3231, 3623, 3891], 'lysates': [2450, 2469, 3669, 3790, 3873], 'colorimetric': [2474, 2720], 'kit': [2476, 2722], 'detection': [2479], 'limit': [2480], '2.5': [2482, 3927], 'μm(Cayman': [2483], 'according': [2488], "manufacturer's": [2491], 'instructions.': [2492], 'Nitrate/nitrite': [2493], 'concentrations': [2494, 3904, 3993], 'averaged': [2496], 'duplicate': [2498], 'triplicate': [2500], 'measurements': [2501], 'nmol': [2505], 'per': [2507], 'mg': [2508], 'protein.': [2510], 'Results': [2511], 'groups': [2514, 2742, 3907], 'normalized': [2517, 2744], 'time': [2520, 2747, 2898, 2920, 3142, 3176, 3210, 3320, 3401, 3439, 3637, 3675, 3806, 3935, 4632, 4713, 4790], 'control.': [2521], 'designated': [2524], 'duration,': [2526, 2537], 'elicited': [2532, 5319], 'field': [2534], '(2-ms': [2536], '1.5-fold': [2538], 'threshold': [2539], 'voltage)': [2540], '0.5': [2542], 'Hz': [2543], 'normal': [2545], "Tyrode's": [2546], 'following': [2550], '(in': [2551], 'mm):': [2552], '140': [2553], 'NaCl,': [2554], '5.4': [2555], 'KCl,': [2556], 'CaCl2,': [2558], '0.8': [2559], 'MgCl2,': [2560], 'HEPES/Tris,': [2562], '5.6': [2564], 'glucose.': [2565], 'CS': [2566, 2689, 2701], 'monitored': [2568], 'edge': [2571], 'motion': [2572, 2610], 'detector': [2573], '(Crescent': [2574], 'Electronics,': [2575], 'Sandy,': [2576], 'UT)': [2577], '(35Liu': [2581], 'Kennedy': [2583, 3587, 3996, 4228], 'R.H.': [2584, 3588, 3997, 4229], 'Creer': [2585], 'M.H.': [2586], 'Howat': [2587], '2003;': [2594], '284:': [2595], 'C826-C838Crossref': [2596], '(17)': [2599], 'voltage': [2603], 'calibrated': [2606], 'actual': [2609], '(μm).': [2611], 'Post-rest': [2612], '(PRP),': [2614], 'assess': [2620], 'handling': [2623], '(36Bers': [2627], 'D.M.': [2628, 2653], 'Li': [2629], 'Satoh': [2631], 'McCall': [2633], 'Ann.': [2635], '853:': [2641], '157-177Crossref': [2642], '(31)': [2645], '37Bassani': [2648], 'J.W.M.': [2649], 'Bassani': [2650], 'R.A.': [2651, 3489, 4964, 5342], 'Bers': [2652], '1993;': [2659, 4868], '265:': [2660], 'C533-C540Crossref': [2661], 'measured': [2666], 'given': [2672], 'rest': [2673, 2704], 'intervals': [2674], '(e.g.': [2675, 4688], 's': [2678, 2682], '(PRP30)': [2679], '(PRP60)).': [2683], 'relative': [2685, 4054], 'amplitude': [2686, 2696, 4049], 'PRP': [2688, 3986], 'presented': [2691, 2750, 3909], 'normalizing': [2693], 'steady-state': [2700], 'interval.': [2705], 'Recombinant': [2706], 'purchased': [2710, 2734], 'Pepro': [2712], 'Tech': [2713], 'Inc': [2714], '(Rocky': [2715], 'Hill,': [2716], 'NJ);': [2717], 'nitrate/nitrite': [2719], 'obtained': [2724, 3875], 'Co.': [2727], 'Cycloheximide,': [2728], 'Calbiochem.': [2736], 'biochemical': [2738], 'assays,': [2739], 'all': [2740], 'means': [2752, 3939], '±': [2753, 3641, 3700, 3940], 'S.E.': [2754, 3941], 'Statistical': [2755], 'significance': [2756], '(p': [2757], '<': [2758, 2916, 3191, 3796, 3949, 3955, 4087, 4094], '0.05)': [2759, 3797, 4088], 'evaluated': [2761], "Student's": [2763], 't': [2764], 'test': [2765], 'analysis': [2767], 'variance': [2769], "Duncan's": [2771], 'multiple': [2772], 'range': [2773], 'test.': [2774], 'gp130-related': [2784], 'cardiotrophin-1': [2810], 'there': [2827], 'data': [2830, 2895, 3070, 3158, 3263, 3384, 3410, 4031, 4152], 'demonstrating': [2831], 'link': [2834], 'whether': [2848, 3533, 4013], 'Fig.': [2858, 2890, 2993, 3153, 3226, 3334, 3378, 3412, 3653, 3779, 4064], 'Ashows': [2860], 'Tyr705': [2866, 3034], 'reached': [2878], 'maximum': [2880], 'declined': [2886], 'shows': [2893, 2995, 3085, 3228, 3337, 3388, 3547, 3731, 4029], 'combined': [2894, 3157, 3383], 'course': [2899, 3321, 4633, 4714, 4791], '9.3-,': [2908], '12.1-,': [2909], '9.7-,': [2910], '7.6-fold': [2912], '(n': [2913, 3187, 3792, 4083, 4091], '=': [2914, 3188, 3793, 4084, 4092], '4,p': [2915], '0.05,': [2917, 3950, 3956], 'compared': [2918, 3399, 3804, 3951, 3957], 'control)': [2921, 3148], '5,': [2923, 3179, 3794], '15,': [2924, 3180], '30,': [2925, 3181], 'respectively.': [2933, 3193, 4068, 4096], 'treatment,': [2948, 3663], 'second': [2951], '(∼': [2953], '2-fold)': [2954], 'observed': [2956, 3775, 3827, 4138, 5132, 5459], '(Fig.': [2960, 3064], 'B).': [2962, 3068], 'Total': [2963], 'remained': [2967, 3150], 'relatively': [2968, 3151, 4776], 'constant': [2969], '(lower': [2974, 4046], 'panel': [2975], 'Fig.1': [2977], 'A).': [2978], 'results': [2980, 3213, 3517, 3709, 3773, 3825, 3839, 4136, 4671, 5017], 'demonstrate': [2981], 'inhibitors': [3002, 3025, 3865, 3924], 'IL-6.': [3016, 3377], 'pretreated': [3019, 3878], 'exposure.': [3028, 3529, 3729], 'μm': [3039, 3047, 3058, 3250, 3254, 3260, 3753, 3763, 3881, 3884, 3888, 4108, 4112, 4118], 'inhibitor': [3063, 3582, 3616, 4357, 4363, 4646], 'A': [3066, 3084, 3336, 3546, 4028], 'suggest': [3071, 3214, 3264, 3518, 3710, 3840, 4153, 4672], 'activation.': [3082, 4370, 5406], 'Fig.3': [3083], 'ERK2': [3092, 3126, 3165, 3197, 3243], 'Tyr204': [3094, 3245], 'IL-6;': [3105], 'followed': [3114], 'decline': [3117], 'Note': [3124], 'predominate': [3129], 'form': [3130], 'myocytes,': [3134, 4695], 'p-ERK2': [3140], '(each': [3141], 'control,': [3143], 'zero-time': [3147], 'constant.': [3152], '3': [3154], 'summarizes': [3156], 'time-dependent': [3161, 3339], '5.2-,': [3169], '5.0-,': [3170], '9.5-,': [3171], '5.1-fold': [3173], '(compared': [3174], 'controls)': [3177], '3,': [3189], 'p': [3190, 3795, 3948, 4086], '0.05),': [3192, 4095], 'significantly': [3207], 'controls.': [3211, 3807, 3936], 'transiently': [3217, 5417], 'marked': [3238], 'independent': [3271], 'induction': [3323, 4717, 5031, 5315], '(∼130': [3344], 'kDa)': [3345], 'undetectable': [3361], 'incubation': [3375, 3456, 3834, 4742], 'B,': [3380], 'represents': [3382], 'five': [3386, 3777], 'experiments,': [3387], 'IL-6-treated': [3394], '9-fold,': [3398], 'controls': [3402], 'treatment.': [3407, 3631], 'Similarly,': [3408, 3652], 'immunocytochemical': [3409], 'C': [3414], 'show': [3415], 'evident': [3419], 'myocyte': [3422, 4045], 'whereas': [3432, 4660, 5147, 5381, 5399], 'barely': [3435], '2-h': [3438, 3455, 3559, 3636, 3728], 'IL-1β,': [3460, 4893], 'inducer': [3464], '(38Balligand': [3470], 'J.-L.': [3471], 'Ungureanu-Longrois': [3472], 'D.': [3473, 3477], 'W.W.': [3475], 'Pimental': [3476], 'Malinski': [3478], 'T.A.': [3479, 4960, 5338], 'Kapturczak': [3480], 'Taha': [3482], 'Z.': [3483], 'Lowenstein': [3484], 'C.J.': [3485], 'Davidoff': [3486], 'Kelly': [3488, 4963, 5341], 'Smith': [3490, 4961, 5339], 'T.W.': [3491, 4962, 5340], 'Michel': [3492], '27580-27588Abstract': [3499], 'positive': [3510], 'experiments.': [3514, 3778, 3946], 'involved': [3539, 4020, 5282, 5403], 'expression.': [3544, 3771, 4541], 'Fig.6': [3545], '(note': [3565], 'completely': [3573, 3683, 3748], '50': [3575], 'nmol/liter': [3576], '2-amino-5,6-dihydro-6-methyl-4H-1,3-thiazine,': [3577], 'potent': [3579], 'selective': [3581], 'iNOS)': [3584], '(39Yu': [3585, 3994, 4226], 'X.-W.': [3586, 3995, 4227], 'Liu': [3589, 3998, 4230, 5483], '32': [3596, 4005, 4237], '(Abstr.': [3597, 4006, 4238], 'J10):': [3598, 4007, 4239], 'A72Google': [3599, 4008, 4240], 'This': [3601, 3808, 5359], '2.5-fold': [3602], 'NOxproduction': [3605], 'abolished': [3607], 'μmcycloheximide': [3613], '(CHX),': [3614], 'applied': [3622], 'prior': [3625], 'NOxconcentration': [3633], '2.65': [3640], '0.46': [3642], 'nmol/mg': [3643, 3702], 'affected': [3649, 5256], 'CHX.': [3651], '6': [3654], 'Bshows': [3655], 'conditions': [3660], '∼3.5-fold': [3672], 'CHX': [3682], 'had': [3692, 3765, 4127], '(2.18': [3699], '0.31': [3701], 'protein)': [3704], 'lysate.': [3707], 'novoprotein': [3713], 'activity': [3717, 4700], 'required': [3721, 4491, 4703], 'Fig.7': [3730], 'pretreatment': [3750, 3760], 'μmgenistein.': [3757], 'Similar': [3772, 3824], '8shows': [3780], '∼2.4-fold': [3791], 'when': [3803], 'lysate': [3830], '4-h': [3833], '(data': [3835, 4148], 'shown).': [3837, 4150], 'pathway,': [3856, 4906], 'pathway.Figure': [3861], '8Effects': [3862], 'production.': [3871], 'Normalized': [3902], 'ratio': [3911], 'value.': [3915], 'alone': [3925, 4126], 'did': [3929], 'differ': [3931], 'Data': [3937], 'represent': [3938], 'eight': [3945], '*,': [3947], 'control;': [3953], '#,p': [3954], 'PD98058': [3959, 4661], 'alone.View': [3960], 'Large': [3961], 'Image': [3962], 'Figure': [3963], 'ViewerDownload': [3964], 'Hi-res': [3965], 'image': [3966], 'Download': [3967], '(PPT)': [3968], 'Our': [3969, 4206], 'preliminary': [3970, 4207], 'findings': [3971, 4244], 'reductions': [3984], 'responsiveness': [3989], 'and/or': [4016], 'negative': [4024, 5014, 5249, 5290], 'effect.': [4026], 'Fig.9': [4027], 'representative': [4030], 'PRP30': [4033, 4051, 4078, 4101, 4131], 'PRP60': [4035, 4053, 4080, 4103], 'time-control': [4038], '(upper': [4039], 'panel)': [4040], 'panel).': [4047], 'pre-rest': [4058], 'steady': [4059], 'state': [4060], '9,B': [4065], 'C,': [4067], 'Exposure': [4069], 'reduced': [4077], '∼34%': [4082], '17,': [4085], '32%': [4090], '16,p': [4093], 'Pretreatment': [4120], 'PRP60.': [4133], 'ERK1/2,': [4170], 'Recently,': [4172], '(40Wollert': [4191], 'K.C.': [4192], 'Drexler': [4193], 'Fail.': [4196], 'Rev.': [4197], '6:': [4199], '95-103Crossref': [4200], '(163)': [4203], 'consistent': [4242, 5019], 'others': [4247], 'defined.': [4285, 4726], 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[4539], 'gene': [4540, 4850], 'Ras-mitogen-activated': [4552], '(or': [4555], 'ERK1/2)': [4556], '32Kodama': [4581], 'present': [4615, 4786, 4996, 5239], 'enhances': [4621], 'similar': [4631], 'activations': [4637], 'genistein.': [4641], '(AG490)': [4647], 'phosphorylation,': [4659, 5007], 'STAT3.': [4669, 5385], 'g130': [4687], 'genistein)': [4691], 'vice': [4710], 'versa.': [4711], 'clearly': [4725], 'may': [4772, 5361], 'short': [4777], 'insults': [4780], 'bypass.': [4784, 5474], 'function.': [4833], 'IL-6-elicited': [4835], 'sustained': [4839], 'cytokine.': [4847], 'promoter': [4851], 'region': [4852], 'sites': [4855], 'STAT': [4857], '(42Xie': [4859], 'Q.W.': [4860], 'Whisnant': [4861], 'Nathan': [4863], '177:': [4869], '1779-1784Crossref': [4870], '(1030)': [4873], 'human': [4878], 'DLD-1': [4879], 'colon': [4882], 'epithelial-derived': [4883], 'line,': [4885], 'cytokine': [4889, 5322], 'mixture': [4890, 5323], 'INF-γ,': [4892], 'tumor': [4895], 'necrosis': [4896], 'factor-α': [4897], 'JAK2/STAT1α': [4905], '(43Kleinert': [4912], 'Wallerath': [4914], 'Fritz': [4916], 'Ihrig-Biedert': [4918], 'Rodriguez-Pascual': [4920], 'Geller': [4922], 'D.A.': [4923], 'Förstermann': [4924], 'Br.': [4926], 'Pharmacol.': [4928], '125:': [4930], '193-201Crossref': [4931], '(128)': [4934], 'INF-γ-induced': [4937], 'paralleled': [4946], 'STAT1α': [4948, 5389], '(44Singh': [4955, 5333], 'Balligand': [4957, 5335], 'Fischer': [4959, 5337], '271:': [4969, 5347], '1111-1117Abstract': [4970, 5348], '(150)': [4978, 5356], 'Therefore,': [4981], 'likely': [4984], 'mediates': [4989, 5029, 5430], 'synthesis.': [4993], 'block': [5004], 'inotropy.': [5015], 'hypothesis': [5022], 'iNOS,': [5033], 'thereby': [5034], 'increasing': [5035], 'decreasing': [5039], 'variety': [5060], 'stimuli.': [5062], 'still': [5076], 'cDNA,': [5146], 'intact': [5152], 'c-fos': [5187], 'atrial': [5189], 'natriuretic': [5190], 'attenuated': [5195], 'suggesting': [5202], 'cross-talk': [5204], 'inotropy': [5250], 'unclear,': [5273], 'clear': [5276], 'nor': [5288], 'contrast': [5300], 'our': [5302], 'results,': [5303], 'essential': [5312], 'INF-γ': [5325, 5376], 'IL-1β': [5327, 5378], 'discrepancy': [5360], 'STATs': [5367], 'cytokines.': [5370], 'combination': [5374], 'STAT1α,': [5380], 'primarily': [5384], 'might': [5390], 'activation,': [5398], 'summary,': [5408], 'Only': [5425], 'could': [5453], 'account': [5454], 'cytokine-associated': [5462], 'disorders': [5464], 'infarction,': [5469], 'ischemia/reperfusion,': [5470], 'myocarditis,': [5471], 'acknowledge': [5476], 'expert': [5478], 'technical': [5479], 'assistance': [5480], 'Meei-Yueh': [5482], 'Kerrey': [5485], 'Roberto.': [5487]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2044681698', 'counts_by_year': [{'year': 2024, 'cited_by_count': 7}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 8}, {'year': 2020, 'cited_by_count': 10}, {'year': 2019, 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