Publication Information

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'https://openalex.org/W2071366179', 'https://openalex.org/W2079374859', 'https://openalex.org/W2094212758', 'https://openalex.org/W2095504227', 'https://openalex.org/W2096890286', 'https://openalex.org/W2101409569', 'https://openalex.org/W2110121929', 'https://openalex.org/W2114796046', 'https://openalex.org/W2149442576', 'https://openalex.org/W2165700649', 'https://openalex.org/W2170882418', 'https://openalex.org/W2313051429', 'https://openalex.org/W2427794290', 'https://openalex.org/W4235335257'], 'related_works': ['https://openalex.org/W4253482303', 'https://openalex.org/W3150231798', 'https://openalex.org/W2886713531', 'https://openalex.org/W2313163197', 'https://openalex.org/W2094249300', 'https://openalex.org/W1997582444', 'https://openalex.org/W1993452556', 'https://openalex.org/W19813757', 'https://openalex.org/W173611471', 'https://openalex.org/W1552843030'], 'abstract_inverted_index': {'Platelet-derived': [0, 277, 554], 'growth': [1, 11, 138, 197, 278, 288, 415, 474, 555, 564, 568, 581, 1543, 1568, 1753, 3587, 4474], 'factors': [2, 279, 556, 1261, 4426], '(PDGFs)': [3, 280, 557], 'play': [4, 281, 1404], 'an': [5, 282, 1465, 3779, 4251], 'integral': [6, 283], 'role': [7, 248, 284, 525, 1406], 'in': [8, 114, 207, 254, 285, 391, 484, 531, 603, 633, 788, 948, 973, 1056, 1164, 1248, 1268, 1407, 1464, 1479, 1526, 1542, 1653, 1825, 1851, 1996, 2281, 2707, 2849, 2863, 2907, 3003, 3288, 3310, 3352, 3417, 3493, 3579, 3676, 3680, 3734, 3867, 3957, 4027, 4053, 4085, 4203, 4217, 4390, 4399, 4438, 4486, 4569, 4693, 4776, 4790], 'normal': [9, 286, 4440], 'tissue': [10, 287, 615, 1366, 4746], 'and': [12, 24, 37, 60, 70, 110, 151, 157, 191, 203, 210, 213, 272, 289, 301, 314, 337, 347, 387, 428, 434, 468, 480, 487, 490, 549, 601, 617, 628, 641, 664, 907, 961, 985, 1051, 1146, 1176, 1237, 1255, 1265, 1279, 1288, 1409, 1459, 1494, 1502, 1516, 1523, 1554, 1606, 1615, 1617, 1685, 1697, 1721, 1765, 1801, 1823, 1846, 1875, 1879, 1896, 1924, 1971, 1975, 2031, 2099, 2125, 2141, 2165, 2192, 2212, 2221, 2233, 2251, 2257, 2263, 2272, 2800, 2829, 2873, 2927, 2967, 2994, 3019, 3021, 3027, 3107, 3137, 3187, 3203, 3233, 3248, 3274, 3303, 3321, 3370, 3404, 3515, 3529, 3575, 3588, 3592, 3701, 3746, 3753, 3755, 3768, 3800, 3879, 3961, 3980, 3991, 4084, 4146, 4222, 4275, 4289, 4406, 4417, 4435, 4441, 4445, 4475, 4491, 4583, 4675, 4718, 4724, 4745, 4782], 'maintenance': [13, 290], 'as': [14, 16, 291, 293, 637, 1090, 1275, 1283, 1365, 2179, 2246, 3100, 3129, 3355, 3543, 3836, 4273, 4404, 4428, 4447, 4736], 'well': [15, 292], 'many': [17, 294, 604, 4282], 'human': [18, 57, 295, 334, 1593, 2100, 2107, 2717, 2828, 2910, 3243], 'pathological': [19, 296, 3593], 'states': [20, 297], 'including': [21, 298, 609, 4286], 'atherosclerosis,': [22, 299, 638], 'fibrosis,': [23, 300, 640], 'tumorigenesis.': [25, 302], 'The': [26, 72, 303, 349, 1155, 1538, 1609, 1631, 1833, 1886, 2037, 2242, 2266, 2739, 2782, 2804, 2819, 3109, 3153, 3264, 3951, 4394, 4457, 4479], 'PDGF': [27, 304, 1141], 'family': [28, 305, 1143], 'of': [29, 33, 47, 55, 75, 87, 130, 162, 249, 306, 310, 324, 332, 352, 364, 407, 439, 526, 598, 606, 959, 1152, 1157, 1170, 1252, 1360, 1430, 1448, 1566, 1576, 1633, 1679, 1688, 1785, 1812, 1828, 1854, 1899, 1906, 1947, 1954, 1998, 2018, 2022, 2034, 2052, 2074, 2093, 2161, 2293, 2699, 2703, 2716, 2761, 2838, 2857, 2876, 2917, 2956, 2965, 2985, 2997, 3039, 3055, 3068, 3083, 3096, 3114, 3125, 3144, 3155, 3231, 3266, 3282, 3291, 3335, 3345, 3415, 3502, 3510, 3513, 3585, 3616, 3661, 3730, 3737, 3781, 3785, 3830, 3872, 3888, 3954, 3966, 3983, 4021, 4152, 4200, 4239, 4267, 4361, 4386, 4396, 4415, 4449, 4459, 4465, 4472, 4672, 4711, 4741, 4766, 4795], 'ligands': [30, 307], 'is': [31, 125, 183, 268, 308, 402, 460, 545, 953, 987, 1052, 1351, 1413, 1439, 2814, 2824, 3425, 3581, 3611, 3778, 4015, 4261, 4409, 4482, 4492, 4580, 4679, 4728, 4738], 'comprised': [32, 309], 'A,': [34, 311], 'B,': [35, 312, 3754, 3962], 'C,': [36, 167, 313, 444], 'D': [38, 315, 1957], 'chains.': [39, 316], 'Here,': [40, 317], 'we': [41, 244, 318, 521, 1424, 2840, 2882, 2972, 3239, 3314, 3347, 3522, 3606, 4023, 4046, 4196, 4300, 4561], 'provide': [42, 319, 1425, 4683], 'the': [43, 48, 56, 76, 88, 127, 131, 163, 181, 218, 246, 320, 325, 333, 353, 365, 404, 408, 440, 458, 495, 523, 621, 630, 969, 1057, 1134, 1167, 1171, 1249, 1253, 1357, 1426, 1431, 1445, 1449, 1507, 1564, 1585, 1602, 1620, 1634, 1673, 1698, 1705, 1750, 1760, 1799, 1847, 1897, 2053, 2065, 2072, 2075, 2091, 2152, 2172, 2282, 2290, 2700, 2704, 2746, 2752, 2759, 2769, 2777, 2810, 2835, 2845, 2850, 2864, 2877, 2908, 2918, 2953, 2957, 2963, 2986, 3047, 3053, 3063, 3081, 3097, 3112, 3141, 3148, 3171, 3191, 3213, 3228, 3236, 3260, 3280, 3292, 3311, 3322, 3375, 3387, 3413, 3418, 3503, 3507, 3511, 3519, 3539, 3546, 3566, 3613, 3659, 3721, 3735, 3762, 3773, 3828, 3831, 3863, 3886, 3924, 3934, 3964, 3978, 3989, 3993, 4019, 4035, 4148, 4182, 4265, 4293, 4330, 4339, 4358, 4384, 4387, 4397, 4422, 4439, 4463, 4487, 4572, 4670, 4680, 4687, 4701, 4705, 4712, 4791], 'first': [44, 321, 1427, 3774, 4681], 'functional': [45, 322, 1428, 2701, 3508], 'characterization': [46, 323, 1429, 2702], 'PDGF-C': [49, 58, 77, 164, 204, 220, 223, 256, 263, 326, 335, 354, 441, 481, 497, 500, 533, 540, 663, 1085, 1408, 1432, 1437, 1450, 1462, 1586, 2284, 2294, 2705, 2719, 2821, 2865, 2878, 2958, 2987, 3237, 3420, 3485, 3504, 3520, 3540, 3576, 3644, 3672, 3732, 3782, 3864, 3995, 4000, 4006, 4013, 4025, 4201, 4212, 4228, 4249, 4298, 4324, 4392, 4480, 4567, 4691, 4719], 'promoter.': [50, 221, 327, 498, 1433, 3421], 'We': [51, 328, 1434, 2711, 3637], 'examined': [52, 329], '797': [53, 330], 'bp': [54, 331, 2775, 2892, 2981], 'promoter': [59, 78, 90, 165, 336, 355, 367, 442, 1411, 1418, 2706, 2784, 2879, 2912, 2920, 2959, 2988, 3050, 3388, 3541, 3996], 'identified': [61, 338, 1089], 'several': [62, 339], 'putative': [63, 340, 2793], 'recognition': [64, 341], 'elements': [65, 342, 2924], 'for': [66, 175, 343, 452, 991, 1241, 1455, 1532, 1559, 1656, 1716, 1755, 1803, 1840, 1883, 1893, 1931, 1942, 2041, 2067, 2085, 2131, 2184, 2189, 2195, 2198, 2204, 2209, 2215, 2218, 2225, 2230, 2236, 2239, 2735, 2796, 2925, 3006, 3272, 3276, 3285, 3654, 3772, 3814, 3842, 4193, 4281, 4313, 4496], 'Sp1,': [67, 344, 2797, 3346], 'Ets': [68, 345, 3071, 3075], 'Egr-1,': [69, 346, 566, 1442, 2222, 2260, 2798, 3984, 4022, 4578], 'Smad.': [71, 348], 'proximal': [73, 219, 350, 496, 1250, 1446, 2909, 2954, 3048, 3419, 3994, 4706], 'region': [74, 86, 161, 351, 363, 438, 1251, 1447, 1582, 2785, 2813, 2862, 2890, 2903, 2916, 2955, 3290], 'bears': [79, 356], 'a': [80, 84, 185, 208, 357, 361, 462, 485, 956, 988, 1091, 1353, 1405, 1469, 1573, 1782, 1790, 1804, 2120, 2713, 2722, 2787, 2858, 2885, 2900, 2976, 3035, 3073, 3340, 3349, 3582, 3681, 4255, 4412, 4470, 4493, 4729], 'remarkable': [81, 358, 4702], 'resemblance': [82, 359], 'to': [83, 169, 360, 446, 1133, 1271, 1356, 1563, 1627, 1660, 1672, 1759, 1798, 1809, 2071, 2693, 2731, 2809, 2833, 2894, 2899, 2905, 2950, 2983, 2992, 3044, 3079, 3092, 3159, 3161, 3168, 3177, 3195, 3253, 3259, 3306, 3330, 3339, 3402, 3408, 3496, 3658, 3678, 3703, 3705, 3798, 3846, 3862, 3883, 3907, 3941, 3947, 3988, 4049, 4185, 4224, 4263, 4317, 4682, 4716, 4721, 4732, 4739, 4769], 'comparable': [85, 362], 'PDGF-A': [89, 366, 627, 984, 1145, 1254, 1264, 2911, 2919, 3049, 3312, 4713], '(1Khachigian': [91, 368, 1178, 1291, 2929], 'L.M.': [92, 369, 1179, 1197, 1220, 1292, 1310, 1333, 1736, 2930, 3432, 3455, 3474, 3627, 4073, 4102, 4133, 4169, 4372, 4610, 4635, 4654, 4749], 'J.': [93, 370, 722, 799, 807, 872, 873, 994, 996, 1004, 1006, 1014, 1016, 1031, 1064, 1180, 1293, 1384, 2355, 2363, 2427, 2428, 2499, 2501, 2509, 2511, 2519, 2521, 2534, 2583, 2631, 2650, 2656, 2931, 3629, 4374, 4501, 4503, 4511, 4513, 4521, 4523, 4538, 4637], 'Biol.': [94, 371, 684, 731, 776, 937, 1019, 1123, 1181, 1210, 1294, 1323, 1385, 2337, 2489, 2524, 2584, 2632, 2932, 3445, 3600, 4526], 'Chem.': [95, 372, 1182, 1295, 1386, 2585, 2633, 2933], '1995;': [96, 373, 1183, 1296, 2934], '270:': [97, 374, 1184, 1297, 2935], '27679-27686Abstract': [98, 375, 1185, 1298, 2936], 'Full': [99, 101, 376, 378, 1186, 1188, 1299, 1301, 1390, 1392, 2589, 2591, 2637, 2639, 2937, 2939], 'Text': [100, 102, 377, 379, 1187, 1189, 1300, 1302, 1391, 1393, 2590, 2592, 2638, 2640, 2938, 2940], 'PDF': [103, 380, 1190, 1303, 1394, 2593, 2641, 2941], 'PubMed': [104, 381, 652, 688, 735, 780, 811, 832, 854, 880, 902, 941, 1023, 1046, 1079, 1127, 1191, 1214, 1231, 1304, 1327, 1344, 1395, 1742, 2341, 2367, 2387, 2409, 2435, 2457, 2493, 2528, 2550, 2594, 2610, 2642, 2661, 2674, 2687, 2942, 3449, 3466, 3480, 4079, 4108, 4139, 4175, 4530, 4553, 4604, 4621, 4660, 4760], 'Scopus': [105, 382, 653, 689, 736, 781, 812, 833, 855, 881, 903, 942, 1024, 1047, 1080, 1128, 1192, 1215, 1232, 1305, 1328, 1345, 1396, 1743, 2342, 2368, 2388, 2410, 2436, 2458, 2494, 2529, 2551, 2595, 2611, 2643, 2662, 2675, 2688, 2943, 3450, 3467, 3481, 4080, 4109, 4140, 4176, 4531, 4554, 4605, 4622, 4661, 4761], '(266)': [106, 383, 1193, 1306, 2944], 'Google': [107, 384, 655, 691, 738, 783, 814, 835, 857, 883, 905, 944, 1026, 1049, 1082, 1130, 1194, 1217, 1234, 1307, 1330, 1347, 1398, 1745, 2344, 2370, 2390, 2412, 2438, 2460, 2496, 2531, 2553, 2597, 2613, 2645, 2664, 2677, 2690, 2945, 3452, 3469, 3483, 3603, 3635, 4082, 4111, 4142, 4178, 4380, 4533, 4556, 4607, 4624, 4643, 4663, 4763], 'Scholar).': [108, 385, 656, 945, 1083, 1235, 1348, 1399, 2691, 3604, 3636, 4112, 4557, 4664, 4764], 'Binding': [109, 386, 2279, 3861], 'transient': [111, 211, 388, 488, 3524], 'transfection': [112, 389, 1713, 1762, 1794], 'analysis': [113, 143, 193, 390, 420, 470, 3033, 3181, 3318, 3526, 3826, 3931], 'primary': [115, 392], 'vascular': [116, 393, 975, 1362, 4401, 4455, 4796], 'smooth': [117, 146, 394, 423, 592, 610, 965], 'muscle': [118, 147, 395, 424, 593, 611, 966], 'cells': [119, 396, 612, 967, 1269, 1508, 1539, 1550, 1751, 1800, 1834, 4204, 4240, 4437], 'revealed': [120, 154, 397, 431, 3189, 3885, 3932], 'that': [121, 155, 195, 214, 262, 398, 432, 472, 491, 539, 981, 1436, 2868, 2884, 2952, 2999, 3111, 3140, 3173, 3190, 3204, 3380, 3609, 3640, 3776, 3933, 3975, 4029, 4238, 4352, 4420, 4451, 4564], 'PDGF-C,': [122, 399, 982, 2181, 2248, 2839], 'like': [123, 400, 983], 'PDGF-A,': [124, 401], 'under': [126, 403, 3590, 3612, 4230], 'transcriptional': [128, 405, 962, 2754, 2836, 3614, 4418, 4688], 'control': [129, 406, 3615], 'zinc': [132, 409, 1172, 4574], 'finger': [133, 410, 1173, 4575], 'nuclear': [134, 149, 411, 426, 1168, 2035, 2995, 3801, 3870, 3981], 'protein': [135, 153, 412, 430, 1095, 3142, 3287, 3843, 4270], 'Egr-1': [136, 156, 171, 202, 216, 233, 271, 413, 433, 448, 479, 493, 510, 548, 1175, 1236, 1401, 2109, 2872, 2926, 2966, 3186, 3208, 3232, 3247, 3302, 3336, 3356, 3371, 3424, 3492, 3500, 3517, 3534, 3574, 3610, 3694, 3742, 3747, 3767, 3786, 3860, 3942, 4002, 4036, 4154, 4355, 4786], '(early': [137, 414], 'response-1).': [139, 416], 'Electrophoretic': [140, 417, 1987], 'mobility': [141, 418, 572], 'shift': [142, 419, 573], 'using': [144, 228, 241, 421, 505, 518, 1549, 1601, 1666, 1704, 1763, 2148, 2158, 2728, 2975, 3034, 3182, 3242, 3319, 3527, 3794, 3869], 'both': [145, 201, 422, 478, 4733], 'cell': [148, 425, 599, 971, 2709, 3586, 4498, 4695, 4777, 4780], 'extracts': [150, 427, 2066, 2996, 3802, 3839, 3871, 3967], 'recombinant': [152, 429, 2101, 2108, 3244, 3256, 3324, 3516], 'Sp1': [158, 174, 435, 451, 1177, 1238, 1403, 1454, 2102, 2928, 2968, 3188, 3200, 3234, 3245, 3273, 3304, 3353, 3369, 3948], 'bind': [159, 436, 3147, 3176, 3305], 'this': [160, 437, 2842, 3122, 3289, 4497, 4559, 4667], '(Oligo': [166, 443], '–35': [168, 445, 2893, 2982, 2991], '–1).': [170, 447, 3254, 3331], 'competes': [172, 449, 1452], 'with': [173, 450, 1453, 1487, 1512, 1520, 1676, 1779, 1816, 1903, 1951, 2064, 2090, 2871, 3131, 3150, 3164, 3235, 3326, 3374, 3398, 3518, 3545, 3564, 3650, 3740, 3808, 3875, 3939, 3998, 4034, 4118, 4189, 4206, 4220, 4242, 4304, 4319, 4348], 'overlapping': [176, 453, 1242, 1456, 2922, 3307], 'binding': [177, 454, 1246, 1457, 2080, 2794, 2923, 3076, 3296, 3308, 3354, 3357, 3749], 'sites': [178, 455, 1247, 2734, 2795, 2848, 3284, 3309], 'even': [179, 456], 'when': [180, 457, 3368, 3558], 'former': [182, 459], 'at': [184, 461, 1162, 1499, 1535, 1572, 1645, 1781, 1837, 1843, 1890, 1934, 1939, 1977, 2044, 2128, 3121, 3685, 3698], 'stoichiometric': [186, 463], 'disadvantage.': [187, 464], 'Reverse': [188, 465], 'transcriptase': [189, 466, 2169, 3668], 'PCR': [190, 467, 1600, 3669], 'supershift': [192, 469, 2048], 'demonstrate': [194, 245, 261, 471, 522, 538, 3717, 3771], 'fibroblast': [196, 473, 580, 1567], 'factor-2': [198, 475, 1569], '(FGF-2)': [199, 476], 'stimulates': [200, 477, 3977, 4354, 4566], 'mRNA': [205, 482, 2142, 3577, 3663, 3673, 3695, 4007, 4155, 4325], 'expression': [206, 224, 483, 501, 1359, 1463, 3674, 3696, 3733, 3743, 4014, 4202, 4213, 4229, 4326, 4356, 4464, 4568], 'time-dependent': [209, 486, 3682], 'manner': [212, 489], 'FGF-2-inducible': [215, 222, 255, 492, 499, 532, 1461, 4005, 4012, 4297, 4323, 4391], 'binds': [217, 494, 1444, 3992], 'was': [225, 502, 1590, 1611, 1637, 1702, 1714, 1776, 1796, 1849, 1888, 1901, 1949, 2039, 2146, 2156, 3117, 3217, 3366, 3556, 3562, 3792, 3899, 3913, 3937, 4214, 4327], 'completely': [226, 503, 3119], 'abrogated': [227, 504], 'catalytic': [229, 506], 'DNA': [230, 507, 1595, 2024, 2720, 3149, 3748], '(DNAzymes)': [231, 508], 'targeting': [232, 509, 1747, 4785], 'but': [234, 251, 511, 528, 1467, 1792, 2791, 3945, 4253, 4336], 'not': [235, 252, 512, 529, 1414, 1468, 3118, 3218, 3384, 3946, 4235, 4337], 'by': [236, 266, 270, 513, 543, 547, 955, 1054, 1166, 1441, 1518, 1599, 1613, 1639, 1928, 2117, 2136, 2758, 3220, 3297, 3395, 3427, 3491, 3665, 3708, 3789, 3823, 4329, 4338, 4411, 4433, 4484, 4586], 'its': [237, 273, 514, 550, 2296, 4767], 'scrambled': [238, 515, 4183], 'counterpart.': [239, 516], 'Moreover,': [240, 517, 1084, 3422], 'pharmacological': [242, 519], 'inhibitors': [243, 520, 2270], 'critical': [247, 524], 'ERK': [250, 527, 1466, 4252, 4274, 4362], 'JNK': [253, 530, 4340], 'expression.': [257, 534, 4001, 4393], 'These': [258, 535, 3758, 3972, 4277, 4345], 'findings': [259, 536], 'thus': [260, 537], 'transcription,': [264, 541], 'activated': [265, 542, 3538], 'FGF-2,': [267, 544], 'mediated': [269, 546, 954, 4410], 'upstream': [274, 551, 1583, 2750], 'kinase': [275, 552, 2268, 2269], 'ERK.': [276, 553], '1The': [558], 'abbreviations': [559], 'used': [560, 4047], 'are:': [561], 'PDGF,': [562], 'platelet-derived': [563], 'factor;': [565, 582], 'early': [567], 'response-1;': [569], 'EMSA,': [570], 'electrophoretic': [571], 'assay;': [574], 'ERK,': [575], 'extracellular': [576], 'signal-regulated': [577], 'kinase;': [578, 586, 590], 'FGF,': [579], 'JNK,': [583], 'c-Jun': [584], 'N-terminal': [585], 'MEK,': [587], 'mitogen-activated': [588, 2267, 4269], 'kinase/ERK': [589], 'SMC,': [591], 'cell.': [594], 'are': [595, 1160, 2245, 2696, 3821, 4040, 4279, 4430, 4452], 'important': [596, 4280, 4773], 'regulators': [597], 'proliferation': [600], 'survival': [602], 'types': [605], 'mesenchymal': [607], 'cells,': [608, 616], '(SMCs),': [613, 968], 'connective': [614], 'fibroblasts.': [618], 'Studies': [619, 978], 'over': [620], 'last': [622], 'two': [623, 3323], 'decades': [624], 'have': [625, 785, 979, 1239, 2288, 3607, 4562], 'implicated': [626, 787], '-B,': [629, 986], 'classical': [631, 1135], 'PDGFs,': [632, 1136], 'pathophysiologic': [634], 'processes': [635, 4285], 'such': [636, 1274, 1282, 1364, 4272, 4403, 4427], 'restenosis,': [639], 'tumorigenesis': [642], '(2Heldin': [643], 'C.': [644, 706, 712, 765, 824, 2326, 2379, 2536, 4596], 'Westermark': [645], 'B.': [646, 720, 921, 1107, 2473], 'Physiol.': [647, 2657, 3630, 4375, 4638], 'Rev.': [648, 2606], '1999;': [649, 1739, 3631, 4076, 4136, 4172, 4376, 4639], '79:': [650], '1283-1316Crossref': [651], '(1978)': [654], 'Since': [657], 'their': [658], 'discovery': [659, 2297], '4': [660, 1844, 1935, 2298, 3686, 3817], 'years': [661, 2299], 'ago,': [662], 'PDGF-D': [665, 1410], '(3Bergsten': [666], 'E.': [667, 716, 793, 1033, 1066, 2349, 4540], 'Uutela': [668, 752, 2313], 'M.': [669, 696, 710, 753, 757, 864, 1029, 1062, 1377, 2314, 2318, 2419, 2542, 2574, 2652, 4536], 'Li': [670, 760, 794, 1034, 1067, 2321, 2350, 4541], 'X.': [671, 741, 795, 840, 1035, 1068, 2302, 2351, 2395, 2600, 4542], 'Pietras': [672, 796, 2352], 'K.': [673, 679, 745, 747, 769, 797, 818, 888, 1041, 1074, 2306, 2308, 2330, 2353, 2373, 2443, 2540, 2570, 4548, 4590], 'Ostman': [674, 770, 800, 2331, 2356], 'A.': [675, 743, 751, 771, 801, 820, 848, 1002, 1732, 2304, 2312, 2332, 2357, 2375, 2403, 2507, 2538, 2624, 2628, 4069, 4098, 4129, 4165, 4509, 4592], 'Heldin': [676, 766, 2327], 'C.H.': [677, 767, 2328], 'Alitalo': [678, 768, 1040, 1073, 2329, 4547], 'Eriksson': [680, 772, 802, 825, 867, 1038, 1071, 2333, 2358, 2380, 2422, 2601, 4545, 4597], 'U.': [681, 773, 803, 826, 868, 1039, 1072, 2334, 2359, 2381, 2423, 2602, 4546, 4598], 'Nat.': [682, 729, 774, 1737, 2335, 4074, 4134, 4170], 'Cell': [683, 730, 775, 1018, 1472, 2336, 2523, 4525], '2001;': [685, 732, 1043, 1076, 2586, 2684, 3601, 4105, 4550, 4657], '3:': [686, 733], '512-516Crossref': [687], '(464)': [690], 'Scholar,': [692, 739, 836, 858, 884, 1027, 1195, 1218, 1308, 1331, 2345, 2371, 2391, 2413, 2439, 2461, 2497, 2532, 2554, 2598, 2614, 2646, 2665, 2678, 3453, 3470, 4534, 4608, 4625, 4644], '4LaRochelle': [693], 'W.J.': [694], 'Jeffers': [695], 'McDonald': [697], 'W.F.': [698], 'Chillakuru': [699], 'R.A.': [700, 724], 'Giese': [701, 932, 1118, 2484], 'N.A.': [702, 704, 925, 933, 1111, 1119, 2477, 2485], 'Lokker': [703, 924, 1110, 2476], 'Sullivan': [705, 918, 1104, 2470], 'Boldog': [707], 'F.L.': [708, 3623, 4368, 4631], 'Yang': [709], 'Vernet': [711], 'Burgess': [713], 'C.E.': [714, 2582], 'Fernandes': [715], 'Deegler': [717], 'L.L.': [718], 'Rittman': [719], 'Shimkets': [721, 723], 'Rothberg': [725], 'J.M.': [726, 2578], 'Lichenstein': [727], 'H.S.': [728], '517-521Crossref': [734], '(316)': [737], '5Li': [740], 'Ponten': [742, 2303], 'Aase': [744, 746, 2305, 2307], 'Karlsson': [748, 821, 2309, 2376, 4593], 'L.': [749, 822, 911, 1097, 2310, 2377, 2463, 4594], 'Abramsson': [750, 819, 2311, 2374, 4591], 'Backstrom': [754, 2315], 'G.': [755, 2316], 'Hellstrom': [756, 2317], 'Bostrom': [758, 2319], 'H.': [759, 761, 838, 870, 892, 1375, 2320, 2322, 2393, 2425, 2447], 'Soriano': [762, 2323], 'P.': [763, 929, 1010, 1115, 1373, 2324, 2481, 2515, 4517], 'Betsholtz': [764, 823, 2325, 2378, 4595], '2000;': [777, 851, 2338, 2406], '2:': [778, 2339], '302-309Crossref': [779, 2340], '(505)': [782, 2343], 'Scholar)': [784, 1050, 1131, 1746, 4083], 'been': [786, 1088, 1421, 3001, 4032], 'angiogenesis': [789], '(6Cao': [790], 'R.': [791, 1012, 2347, 2517, 4519], 'Brakenhielm': [792, 2348], 'Widenfalk': [798, 2354], 'Cao': [804, 2360], 'Y.': [805, 896, 913, 1099, 2361, 2451, 2465, 2648], 'FASEB': [806, 2362], '2002;': [808, 829, 899, 1020, 2364, 2384, 2454, 2525, 2547, 2671, 4527, 4601], '16:': [809, 2365], '1575-1583Crossref': [810, 2366], '(183)': [813, 2369], 'Scholar),': [815, 906, 2946, 3484, 4143, 4179, 4381], 'embryogenesis': [816], '(7Aase': [817, 4589], 'Mech.': [827, 849, 897, 2382, 2404, 2452, 4599], 'Dev.': [828, 850, 898, 2383, 2405, 2453, 4600], '110:': [830, 2385, 4602], '187-191Crossref': [831, 2386, 4603], '(54)': [834, 2389, 4606], '8Ding': [837, 2392], 'Wu': [839, 2394], 'Kim': [841, 2396], 'I.': [842, 2397], 'Tam': [843, 2398], 'P.P.L.': [844, 2399], 'Koh': [845, 2400], 'G.Y.': [846, 2401], 'Nagy': [847, 2402], '96:': [852, 2407], '209-213Crossref': [853, 2408], '(93)': [856, 2411], '9Eitner': [859, 2414], 'F.': [860, 890, 2415, 2445, 3619, 4364, 4627], 'Ostendorf': [861, 2416], 'T.': [862, 886, 894, 1206, 1226, 1319, 1339, 2417, 2441, 2449, 3441, 3461, 4616, 4755], 'Krewtzler': [863, 2418], 'Cohen': [865, 2420], 'C.D.': [866, 2421], 'Grone': [869, 2424], 'Floege': [871, 2426], 'Am.': [874, 2429, 2655, 3628, 4373, 4636], 'Soc.': [875, 2430], 'Nephrol.': [876, 2431], '2003;': [877, 2432, 2607, 2634], '14:': [878, 2433, 2608], '1145-1153Crossref': [879, 2434], '(65)': [882, 2437], '10Hamada': [885, 2440], 'Ui-Tei': [887, 2442], 'Takahashi': [889, 2444], 'Onodera': [891, 2446], 'Mishima': [893, 2448], 'Miyata': [895, 2450], '112:': [900, 2455], '161-164Crossref': [901, 2456], '(19)': [904, 2459], 'platelet': [908, 1092], 'activation': [909, 4020, 4199, 4266, 4360, 4692], '(11Fang': [910, 1096], 'Yan': [912, 1098, 2464], 'Komuves': [914, 1100, 2466], 'L.G.': [915, 1101, 2467], 'Yonkovich': [916, 1102, 2468], 'S.': [917, 923, 998, 1000, 1008, 1103, 1109, 2469, 2475, 2503, 2505, 2513, 4505, 4507, 4515], 'C.M.': [919, 1105, 2471], 'Stringer': [920, 1106, 2472], 'Galbraith': [922, 1108, 2474], 'Hwang': [926, 1112, 2478], 'S.S.': [927, 1113, 2479], 'Nurden': [928, 1114, 2480], 'Phillips': [930, 1116, 2482], 'D.R.': [931, 1117, 2483], 'Arterioscler.': [934, 1120, 1207, 1320, 2486, 3442], 'Thromb.': [935, 1121, 1208, 1321, 2487, 3443, 4655], 'Vasc.': [936, 1122, 1209, 1322, 2488, 3444], '2004;': [938, 1124, 2490, 2658], '24:': [939, 1125, 2491], '787-792Crossref': [940, 1126, 2492], '(38)': [943, 1129, 2495], 'Neointima': [946], 'formation': [947, 3054, 3095, 3113, 3265, 3887, 4052, 4395], 'atherosclerosis': [949, 4405], 'or': [950, 1683, 1690, 1817, 2106, 2737, 3295, 3560, 3809, 3816, 4180, 4309], 'post-angioplasty': [951, 4407], 'restenosis': [952, 4408], 'complex': [957, 3115, 3197, 3205, 3215, 3834, 3897, 3936, 3955, 4413], 'series': [958, 4414], 'signaling': [960, 4294, 4416], 'events': [963, 4419], 'involving': [964, 1718], 'hallmark': [970], 'type': [972, 4499], 'these': [974, 1260, 3084, 3145, 3381, 4231, 4734], 'occlusive': [976, 4400, 4797], 'disorders.': [977, 4798], 'shown': [980, 3608], 'potent': [989, 4494], 'mitogen': [990, 4495], 'SMCs': [992, 1055, 1476, 1644, 2998, 3494, 3647, 3806, 3873, 4028, 4114, 4218, 4485, 4570], '(12Dijkmans': [993, 4500], 'Xu': [995, 2500, 4502], 'Masure': [997, 2502, 4504], 'Dhanaraj': [999, 2504, 4506], 'Gosiewska': [1001, 2506, 4508], 'Gessin': [1003, 2508, 4510], 'Sprengel': [1005, 2510, 4512], 'Harris': [1007, 2512, 4514], 'Verhasselt': [1009, 2514, 4516], 'Gordon': [1011, 2516, 4518], 'Yon': [1013, 2518, 4520], 'Int.': [1015, 2520, 4522], 'Biochem.': [1017, 2522, 2543, 4524], '34:': [1021, 2526, 4528], '414-426Crossref': [1022, 2527, 4529], '(18)': [1025, 2530, 4532], '13Uutela': [1028, 4535], 'Lauren': [1030, 1063, 4537], 'Bergsten': [1032, 1065, 4539], 'Horelli-Kuitunen': [1036, 1069, 4543], 'N.': [1037, 1070, 1204, 1317, 1383, 3439, 3598, 4544], 'Circulation.': [1042, 1075, 4549], '103:': [1044, 1077, 4551], '2242-2247Crossref': [1045, 1078, 4552], '(106)': [1048, 1081, 4110, 4555], 'expressed': [1053, 4432, 4483], 'intact': [1058, 4488], 'arterial': [1059, 4587], 'wall': [1060, 4444, 4490], '(13Uutela': [1061], 'has': [1086, 1419], 'recently': [1087], 'α-granule': [1093], 'secretory': [1094], 'similar': [1132, 3174], 'suggesting': [1137], 'common': [1138, 1150, 1355, 4730], 'functions': [1139], 'between': [1140, 1259, 1551, 2827, 3720, 3766, 4704], 'ligand': [1142], 'members.': [1144], 'PDGF-B': [1147, 1256, 1266], 'also': [1148, 1352, 2961, 4698], 'share': [1149], 'mechanisms': [1151, 4689], 'gene': [1153, 1159], 'regulation.': [1154], 'promoters': [1156, 4723], 'each': [1158, 3178, 3286], 'controlled,': [1161], 'least': [1163], 'part,': [1165], 'activity': [1169, 1701, 3788], 'proteins': [1174, 3175, 3257, 3325, 3382], '14Khachigian': [1196, 1309], 'Halnon': [1198, 1311, 3433], 'N.J.': [1199, 1312, 3434], 'Gimbrone': [1200, 1313, 3435], 'Jr.,': [1201, 1314, 3436], 'M.A.': [1202, 1315, 3437], 'Resnick': [1203, 1316, 3438], 'Collins': [1205, 1225, 1318, 1338, 3440, 3460, 4615, 4754], '1997;': [1211, 1324, 3446, 3477], '17:': [1212, 1325, 3447], '2280-2286Crossref': [1213, 1326, 3448], '(174)': [1216, 1329, 3451], '15Khachigian': [1219, 1332, 3454, 4609], 'Linder': [1221, 1334, 3456, 4611, 4750], 'V.': [1222, 1335, 3457, 4612, 4751], 'Williams': [1223, 1336, 3458, 4613, 4752], 'A.J.': [1224, 1337, 3459, 4614, 4753], 'Science.': [1227, 1340, 3462, 4617, 4756], '1996;': [1228, 1341, 1387, 3463, 4618, 4757], '271:': [1229, 1342, 1388, 3464, 4619, 4758], '1427-1432Crossref': [1230, 1343, 3465, 4620, 4759], '(476)': [1233, 1346, 3468, 4623, 4762], 'affinity': [1240], 'G': [1243, 2816, 2859, 2887, 4707], '+': [1244, 2817, 2860, 2888, 4708], 'C-rich': [1245, 2861, 2889, 4709], 'promoters.': [1257], 'Interplay': [1258], 'mediates': [1262, 1460, 3642], 'inducible': [1263, 1358], 'transcription': [1267, 1438, 3486, 4576], 'exposed': [1270, 3495, 4223], 'chemical': [1272], 'stresses': [1273, 1281], 'phorbol': [1276], '12-myristate': [1277], '13-acetate': [1278], 'environmental': [1280], 'altered': [1284], 'fluid': [1285], 'shear': [1286], 'stress': [1287], 'mechanical': [1289], 'injury': [1290, 4059, 4588], 'Egr-1/Sp1': [1349, 4726], 'interplay': [1350, 2078, 3416, 4727], 'feature': [1354], 'other': [1361, 3132, 4466], 'genes': [1363, 4774], 'factor': [1367, 4577, 4747], '(16Cui': [1368], 'M.Z.': [1369], 'Parry': [1370], 'G.C.': [1371], 'Oeth': [1372], 'Larson': [1374], 'Smith': [1376], 'Huang': [1378], 'R.P.': [1379], 'Adamson': [1380], 'E.D.': [1381], 'Mackman': [1382], '2731-2739Abstract': [1389], '(151)': [1397], 'Whether': [1400], 'and/or': [1402, 3246, 4793], 'regulation': [1412, 2837], 'known,': [1415], 'because': [1416, 3423], 'neither': [1417], 'yet': [1420], 'characterized.': [1422], 'Here': [1423], 'show': [1435], 'governed': [1440], 'which': [1443, 2947, 3531, 3760, 3985, 4045, 4144, 4579], 'promoter,': [1451, 3238, 3293, 3313, 3521], 'sites,': [1458], 'JNK-dependent': [1470, 4256], 'manner.': [1471], 'Culture—Primary': [1473], 'rat': [1474, 4054, 4153], 'aortic': [1475], 'were': [1477, 1509, 1540, 1547, 1557, 1651, 1663, 1693, 1752, 1820, 1835, 1993, 2062, 2082, 2115, 2178, 2274, 3337, 3372, 3648, 3840, 4115], 'cultured': [1478], "Waymouth's": [1480], 'MB752/1': [1481], 'medium': [1482, 1655], '(Invitrogen),': [1483], 'pH': [1484, 1831, 1861, 1913, 1961], '7.4,': [1485], 'supplemented': [1486], '10': [1488, 1491, 1826, 1841, 1866, 2002], 'units/ml': [1489], 'penicillin,': [1490], 'μg/ml': [1492], 'streptomycin,': [1493], '10%': [1495], 'fetal': [1496], 'calf': [1497], 'serum': [1498, 2095], '37': [1500, 1536], '°C': [1501, 1979, 2130, 2183, 2188, 2194, 2203, 2208, 2214, 2224, 2229, 2235], '5%': [1503, 2014], 'CO2.': [1504], 'At': [1505], 'confluence,': [1506], 'rinsed': [1510], 'twice': [1511, 1822], 'phosphate-buffered': [1513], 'saline': [1514], 'solution': [1515, 1530], 'passaged': [1517], 'incubating': [1519], '0.05%': [1521], 'trypsin': [1522], '0.02%': [1524], 'EDTA': [1525], "Hanks'": [1527], 'balanced': [1528], 'salt': [1529], '(BioWhittaker)': [1531], '7–10': [1533], 'min': [1534, 1842, 1933, 2043, 2069, 2087, 2197, 2217, 2238], '°C.': [1537, 1936, 2046], 'resuspended': [1541, 1850], 'medium.': [1544], 'All': [1545, 1982], 'experiments': [1546], 'performed': [1548, 1715, 2973, 3240, 3315, 3523, 3793], 'passages': [1552], '5': [1553, 1677, 1884, 2159], '8.': [1555], 'Cells': [1556, 1692], 'growth-arrested': [1558, 3002], '24': [1560, 3007, 3709], 'h': [1561, 1658, 1757, 1807, 2133, 3687, 3700, 3710, 3927, 4315], 'prior': [1562, 1659, 1758, 1808, 2070, 3657, 3702, 3845, 4316], 'addition': [1565, 2073, 2092], '(FGF-2;': [1570], 'Promega)': [1571], 'final': [1574, 1768, 1783], 'concentration': [1575, 1784, 3844], '25': [1577, 1786], 'ng/ml.': [1578, 1787], 'Plasmid': [1579], 'Construction—The': [1580], '1288-bp': [1581, 2820], 'from': [1584, 1592, 2276, 2721, 2751, 3804, 3968, 4237], 'ATG': [1587], 'start': [1588, 2755, 4150], 'site': [1589, 2756, 4151], 'amplified': [1591], 'genomic': [1594, 2718, 2822], '(Roche': [1596, 1668, 2725], 'Applied': [1597, 1669, 2726], 'Science)': [1598, 2727], 'primers': [1603, 2244, 2729], '5′-ATGCTAGCCCTGAACACAAGCCACAAGA-3′': [1604], '(forward)': [1605, 2250, 2256, 2262], '5′-CGCTCGAGTTGTTGCTGGAAAACTGGAA-3′': [1607], '(reverse).': [1608, 2265], 'fragment': [1610, 2715, 2843], 'cleaved': [1612], 'NheI': [1614, 2736], 'XhoI': [1616], 'ligated': [1618], 'into': [1619, 2844, 4686], 'firefly': [1621, 2851], 'luciferase-based': [1622, 2852], 'reporter': [1623, 1635, 1680, 2853], 'vector': [1624, 3569], 'pGL3-basic': [1625, 1684], '(Promega)': [1626, 2105, 2170], 'create': [1628], 'construct': [1629, 1636, 1681, 2854], 'pPDGF-C-797.': [1630], 'integrity': [1632], 'confirmed': [1638], 'nucleotide': [1640, 2749, 2805], 'sequencing.': [1641], 'Transient': [1642], 'Transfections—Primary': [1643], '70%': [1646], 'confluence': [1647], '(100-mm': [1648], 'Petri': [1649], 'dishes)': [1650], 'incubated': [1652, 1802, 1880, 2040, 2063, 4301], 'serum-free': [1654, 1774, 3004], '6': [1657, 1756, 1806, 4194], 'transfection.': [1661], 'Transfections': [1662], 'carried': [1664, 1994, 2083], 'out': [1665, 1995, 2084, 4700], 'FuGENE6': [1667, 1764], 'Science),': [1670], 'according': [1671, 2151, 2171], "manufacturer's": [1674, 2153, 2173], 'guidelines,': [1675], 'μg': [1678, 1687, 2017, 2021, 2033, 2160], 'pPDGF-C-797': [1682, 3528], '3': [1686], 'pCB6': [1689, 3561], 'pCB6-Egr-1.': [1691], 'harvested': [1694], '24h': [1695], 'later,': [1696, 1772, 1789], 'corresponding': [1699, 2846], 'luciferase': [1700, 3568], 'quantified': [1703], 'Dual': [1706], 'Luciferase': [1707], 'Reporter': [1708], 'Assay': [1709, 1990], '(Promega).': [1710], 'A': [1711, 1857, 3042, 3102, 3106, 3136, 3157, 3400, 3752, 3960], 'double': [1712], 'transfections': [1717], 'DNAzymes': [1719, 4003, 4039], '(ED5': [1720], 'ED5SCR)': [1722], '(27Santiago': [1723, 4060, 4120, 4156], 'F.S.': [1724, 4061, 4121, 4157], 'Lowe': [1725, 3620, 4062, 4122, 4158, 4365, 4628], 'H.C.': [1726, 3621, 4063, 4092, 4123, 4159, 4366, 4629, 4646], 'Kavurma': [1727, 4064, 4095, 4124, 4160], 'M.M.': [1728, 4065, 4096, 4125, 4161], 'Chesterman': [1729, 3624, 4066, 4099, 4126, 4162, 4369, 4632, 4647], 'C.N.': [1730, 3625, 4067, 4100, 4127, 4163, 4370, 4633, 4648], 'Baker': [1731, 4068, 4097, 4128, 4164], 'Atkins': [1733, 4070, 4130, 4166], 'D.G.': [1734, 2556, 4071, 4131, 4167], 'Khachigian': [1735, 3473, 3626, 4072, 4101, 4132, 4168, 4371, 4634, 4653], 'Med.': [1738, 4075, 4135, 4171], '5:': [1740, 4077, 4137, 4173], '1264-1269Crossref': [1741, 4078, 4138, 4174], '(240)': [1744, 4081, 4141, 4177], 'Egr-1.': [1748, 3837], 'Briefly': [1749], 'arrested': [1754], 'initial': [1761], 'DNAzyme': [1766, 4037], '(0.4μm,': [1767], 'concentration).': [1769], 'Eighteen': [1770], 'hours': [1771], 'fresh': [1773], 'media': [1775, 3005], 'added': [1777, 1797, 3338], 'together': [1778], 'FGF-2': [1780, 1819, 3572, 3617, 3641, 3651, 3679, 3692, 3738, 3769, 3777, 3811, 3858, 3876, 3908, 3976, 4190, 4225, 4243, 4247, 4320, 4353, 4429, 4460, 4565], 'Minutes': [1788], 'second': [1791], 'identical': [1793], 'mix': [1795], 'further': [1805, 3226], 'harvesting.': [1810], 'Preparation': [1811, 2140], 'Nuclear': [1813, 3838], 'Extracts—SMCs': [1814], 'treated': [1815, 3649, 3807, 3874], 'without': [1818, 3810], 'washed': [1821], 'scraped': [1824], 'ml': [1827], 'cold': [1829, 1855, 1907, 1955], 'PBS,': [1830], '7.4.': [1832], 'centrifuged': [1836, 1889], '1200': [1838], 'rpm': [1839, 1892, 1941], '°C,': [1845], 'pellet': [1848, 1898], '100': [1852, 1963], 'μl': [1853, 1905, 1946, 1953, 2000, 2051], 'Buffer': [1856, 1908, 1956], '(10': [1858, 4307], 'mm': [1859, 1864, 1867, 1870, 1873, 1911, 1916, 1919, 1922, 1926, 1959, 1964, 1967, 1973, 2003, 2006, 2009, 2012], 'HEPES,': [1860, 1912, 1960], '8,': [1862, 1914, 1962], '1.5': [1863, 1915], 'MgCl2,': [1865, 1917], 'KCl,': [1868, 1965], '0.5': [1869], 'dithiothreitol,': [1871, 2013], '20': [1872, 1904, 1932, 1945, 1952, 1999], 'sucrose,': [1874], '0.5%': [1876], 'Nonidet': [1877], 'P-40)': [1878], 'on': [1881, 2088, 2119], 'ice': [1882, 2089], 'min.': [1885], 'suspension': [1887], '1400': [1891, 1940], '40': [1894, 2199], 's,': [1895, 2186, 2191, 2206, 2211, 2227, 2232], 'nuclei': [1900], 'lysed': [1902], 'C': [1909, 2990, 3090, 3166, 3193, 3251, 3328, 3406, 3796, 3881], '(20': [1910, 1958], '420': [1918], 'NaCl,': [1920, 2007], '0.2': [1921, 1966], 'EDTA,': [1923, 1968, 2010], '1': [1925, 1943, 1972, 2008, 2011, 2016, 2020, 2050, 2132, 2216, 2237, 4314], 'dithiothreitol)': [1927, 1974], 'mixing': [1929], 'gently': [1930], 'After': [1937, 4187], 're-centrifugation': [1938], 'min,': [1944], 'supernatant': [1948], 'combined': [1950], '20%': [1969], 'glycerol,': [1970, 2015], 'stored': [1976], '–80': [1978], 'until': [1980], 'use.': [1981], 'buffers': [1983], 'contained': [1984], 'protease': [1985], 'inhibitors.': [1986], 'Mobility': [1988], 'Shift': [1989], '(EMSA)—Binding': [1991], 'reactions': [1992, 2081], 'volume': [1997], 'containing': [2001, 3342], 'Tris-HCl,': [2004], '50': [2005], 'poly(dI-dC),': [2019], 'salmon': [2023], '(Sigma),': [2025], '32P-labeled': [2026, 3249], 'oligonucleotide': [2027, 2979, 3128, 3261, 3376], 'probe': [2028], '(100,000': [2029], 'cpm),': [2030], '6–10': [2032], 'extract.': [2036], 'reaction': [2038, 3341], '30': [2042, 2185, 2190, 2205, 2210, 2226, 2231, 2240], '22': [2045], 'In': [2047, 2077, 3061, 3211, 3552, 4210, 4558], 'studies,': [2049], 'indicated': [2054, 3822], 'affinity-purified': [2055], 'rabbit': [2056], 'anti-peptide': [2057], 'antibodies': [2058, 3183, 3222, 3940], '(Santa': [2059], 'Cruz': [2060, 2764], 'Biotechnology)': [2061], '15': [2068, 2086], 'probe.': [2076], 'experiments,': [2079], 'bovine': [2094], 'albumin': [2096], '(2': [2097], 'μg)': [2098], '(12.5–100': [2103], 'ng)': [2104, 2111], '(20–80': [2110], '(Alexis': [2112], 'Biochemicals).': [2113], 'Samples': [2114], 'resolved': [2116], 'electrophoresis': [2118], '6%': [2121], 'non-denaturing': [2122], 'polyacrylamide': [2123], 'gel': [2124], 'vacuum': [2126], 'dried': [2127], '80': [2129], 'before': [2134], 'visualization': [2135], 'autoradiography.': [2137], 'Total': [2138], 'RNA': [2139, 2145], 'Expression': [2143, 3578], 'Analysis—Total': [2144], 'prepared': [2147], 'TRIzol®': [2149], '(Invitrogen)': [2150], 'instructions.': [2154, 2174], 'cDNA': [2155], 'generated': [2157], 'total': [2162], 'RNA,': [2163], 'oligo(dT),': [2164], 'Superscript': [2166], 'II': [2167], 'reverse': [2168, 3667], 'Thermal': [2175], 'cycling': [2176], 'conditions': [2177, 3594, 4233], 'follows:': [2180, 2247], '98': [2182, 2202, 2223], '62.5': [2187], '72': [2193, 2213, 2234], '2': [2196, 3699, 3815, 3917, 3926], 'cycles;': [2200, 2220], 'β-actin,': [2201, 2254], '61': [2207], '18': [2219], '52': [2228], 'cycles.': [2241], 'relative': [2243], '5′-TCCAGCAACAAGGAACAGAAC-3′': [2249], '5′-CTGAAGGGGGTAGCTCTGAA-3′': [2252], '(reverse);': [2253, 2259], '5′-TGACGGGGTCACCCACACTGTGCCCATCTA-3′': [2255], '5′-CTAGAAGCATTTGCGGTGGACGATGGAGGG-3′': [2258], '5′-GCATGTAACGCGGCCA-3′': [2261], '5′-CCGAACGGGTCAGAGAT-3′': [2264], 'PD98059': [2271, 4306, 4333], 'SP600125': [2273, 4310, 4342], 'purchased': [2275], 'Calbiochem.': [2277], 'Putative': [2278], 'Sites': [2280], 'Human': [2283], 'Promoter—': [2285], 'Numerous': [2286], 'studies': [2287, 3397], 'investigated': [2289], 'biological': [2291], 'roles': [2292], 'since': [2295], 'ago': [2300], '(5Li': [2301], '6Cao': [2346], '7Aase': [2372], '11Fang': [2462], '12Dijkmans': [2498], '17Andrae': [2533], 'Molander': [2535], 'Smits': [2537], 'Funa': [2539], 'Nister': [2541], 'Biophys.': [2544], 'Res.': [2545, 3476, 4104], 'Commun.': [2546], '296:': [2548], '604-611Crossref': [2549], '(31)': [2552, 2644], '18Gilbertson': [2555], 'Duff': [2557], 'M.E.': [2558], 'West': [2559], 'J.W.': [2560], 'Kelly': [2561], 'J.D.': [2562], 'Sheppard': [2563], 'P.O.': [2564], 'Hofstand': [2565], 'P.D.': [2566], 'Gao': [2567], 'Z.': [2568], 'Showmaker': [2569], 'Bukowski': [2571], 'T.R.': [2572], 'Moore': [2573], 'Feldhaus': [2575], 'A.L.': [2576], 'Humes': [2577], 'Palmer': [2579], 'T.E.': [2580], 'Hart': [2581], '276:': [2587], '27406-27414Abstract': [2588], '(230)': [2596], '19Li': [2599], 'Cytokine': [2603], 'Growth': [2604, 4425], 'Factor': [2605], '91-98Crossref': [2609], '(163)': [2612], '20Reigstad': [2615], 'L.J.': [2616], 'Sande': [2617], 'H.M.': [2618], 'Fluge': [2619], 'O.': [2620, 2622], 'Bruland': [2621], 'Muga': [2623], 'Varhaug': [2625], 'J.E.': [2626], 'Martinez': [2627], 'Lillehaug': [2629], 'J.R.': [2630], '278:': [2635], '17114-17120Abstract': [2636], '21Zhuo': [2647], 'Zhang': [2649], 'Laboy': [2651], 'Lasky': [2653], 'J.A.': [2654], '286:': [2659], 'L182-L188Crossref': [2660], '(62)': [2663], '22Zwerner': [2666], 'J.P.': [2667, 2680], 'May': [2668, 2681], 'W.A.': [2669, 2682], 'Oncogene.': [2670, 2683], '21:': [2672], '3847-3854Crossref': [2673], '(45)': [2676], '23Zwerner': [2679], '20:': [2685], '626-633Crossref': [2686], '(101)': [2689], 'However,': [2692], 'date': [2694], 'there': [2695], 'no': [2697, 3554, 4198], 'reports': [2698], 'any': [2708, 4694], 'type.': [2710, 4696], 'isolated': [2712], '1.395-kb': [2714], 'commercial': [2723], 'source': [2724], 'engineered': [2730], 'contain': [2732], 'restriction': [2733, 2847], 'XhoI.': [2738], '5′': [2740, 2748, 2779, 2811], 'primer': [2741, 2771], 'targeted': [2742, 2772], 'position': [2743, 2773], '–797': [2744], '(as': [2745], 'extreme': [2747], 'predicted': [2753], 'defined': [2757], 'University': [2760], 'California': [2762], 'Santa': [2763], 'genome': [2765], 'data': [2766, 3391, 3973], 'base),': [2767], 'whereas': [2768], '3′': [2770], '598': [2774], 'spanning': [2776, 2980], 'entire': [2778], 'untranslated': [2780, 2812], 'region.': [2781], '797-bp': [2783], 'lacks': [2786], 'consensus': [2788, 3074], 'TATA': [2789], 'box': [2790], 'contains': [2792, 2921, 3199, 3207], 'Ets-1,': [2799], 'Smad': [2801], '(Fig.': [2802, 2880, 2913, 2969, 3029, 3059, 3086, 3134, 3201, 3209, 3223, 3262, 3269, 3361, 3377, 3392, 3410, 3535, 3550, 3570, 3670, 3688, 3711, 3723, 3744, 3750, 3891, 3902, 3909, 3928, 3943, 3949, 4208, 4226, 4245, 4334, 4343], '1A).': [2803], 'sequence': [2806, 2823, 3051], 'immediately': [2807], 'adjacent': [2808], 'extremely': [2815], 'C-rich.': [2818], '∼80%': [2825], 'homologous': [2826], 'mouse.': [2830], 'To': [2831, 3225, 4291], 'begin': [2832], 'investigate': [2834], 'subcloned': [2841], 'pGL3-basic.': [2855], 'Identification': [2856], 'Proximal': [2866, 3865], 'Promoter': [2867, 3866], 'Physically': [2869], 'Interacts': [2870], 'Sp1—Upon': [2874], 'examination': [2875], '1A),': [2881], 'discovered': [2883], '35-bp': [2886], '(spanning': [2891], '–1)': [2895, 2993, 3093, 3169, 3196, 3409, 3799, 3884, 4722], 'possesses': [2896], 'striking': [2897], 'similarity': [2898, 4703], 'comparably': [2901], 'sized': [2902], '(–6': [2904], '–47)': [2906, 3045, 3160, 3403, 4717], '1B).': [2914, 2970], 'This': [2915, 3390], 'led': [2948], 'us': [2949], 'hypothesize': [2951], 'might': [2960], 'support': [2962], 'interaction': [2964, 3230, 3512], 'Accordingly,': [2971], 'EMSA': [2974, 3241, 3320, 3791], '32P-labeled,': [2977], 'double-stranded': [2978], '–1': [2984], '(32P-Oligo': [2989], 'had': [3000, 4030], 'h.': [3008, 3818], 'Six': [3009], 'nucleoprotein': [3010, 3214, 3833, 3935], 'complexes': [3011, 3058, 3085, 3099, 3133, 3146, 3268, 3889], 'formed,': [3012], 'i.e.': [3013], 'three': [3014, 3022], 'major': [3015], '(complexes': [3016, 3024], 'N1,': [3017], 'N5,': [3018], 'N6)': [3020], 'minor': [3023], 'N2,': [3025], 'N3,': [3026], 'N4)': [3028], '2A).': [3030, 3060, 3087], 'Cold': [3031], 'competition': [3032, 3317], '50-fold': [3036], 'molar': [3037, 3066, 3123], 'excess': [3038, 3067, 3124], 'unlabeled': [3040, 3069, 3127], 'Oligo': [3041, 3070, 3089, 3101, 3156, 3165, 3250, 3399, 3405], '(–76': [3043, 3158, 3401], 'bearing': [3046], 'inhibited': [3052, 3094, 3120], 'all': [3056], 'six': [3057], 'contrast,': [3062, 3212, 3553, 4211], 'same': [3064, 3098], 'fold': [3065], '(bearing': [3072], 'site)': [3077], 'failed': [3078], 'alter': [3080, 4421], 'profile': [3082, 3216], 'Unlabeled': [3088], '(–35': [3091, 3167, 3194, 3252, 3329, 3407, 3797, 3882, 4720], '(compare': [3103], 'Fig.': [3104, 3756, 3958], '2,': [3105, 3135, 3751, 3959], 'B).': [3108], 'fact': [3110], 'N5': [3116], 'either': [3126, 3279, 4117, 4305], 'compared': [3130, 3544], 'B)': [3138], 'indicates': [3139, 3412, 4383], 'components': [3143], 'different': [3151], 'affinities.': [3152], 'capacity': [3154], 'specifically': [3162], 'compete': [3163], 'suggests': [3170, 3278], 'possibility': [3172], 'oligonucleotide.': [3179], 'Supershift': [3180, 3825, 3930], 'raised': [3184], 'against': [3185], '32P-Oligo': [3192, 3327, 3795, 3880], 'N1': [3198], '2B)': [3202, 3411], 'N3': [3206, 3912, 3956], '2B).': [3210, 3224], 'affected': [3219], 'Sp3': [3221], 'confirm': [3227], 'physical': [3229], 'Both': [3255], 'bound': [3258], '3A).': [3263], 'multiple': [3267, 3283, 3428, 4268, 4771], '3A;': [3270], 'S1–S2': [3271], 'E1–E4': [3275], 'Egr-1)': [3277], 'existence': [3281, 3414], 'self-association,': [3294], 'partially': [3298], 'degraded': [3299], 'species.': [3300], 'Because': [3301, 4765], 'protein-protein': [3316], 'When': [3332], 'increasing': [3333], 'amounts': [3334, 3344], 'fixed': [3343], 'observed': [3348, 3367, 3557, 4197], 'dose-dependent': [3350], 'reduction': [3351], 'became': [3358], 'more': [3359], 'apparent': [3360, 3915], '3B).': [3362], 'No': [3363], '"super"': [3364], 'species': [3365], 'co-incubated': [3373], '3B),': [3378, 3393], 'indicating': [3379], 'do': [3383], 'simultaneously': [3385], 'occupy': [3386], 'fragment.': [3389], 'supported': [3394], 'cross-competition': [3396], 'induced': [3426, 3693, 3901, 4216, 4585], 'pro-atherogenic': [3429], 'stimuli': [3430], '(14Khachigian': [3431], '24Delbridge': [3471], 'G.J.': [3472], 'Circ.': [3475, 4103], '81:': [3478], '282-288Crossref': [3479], '(55)': [3482], 'may': [3487, 4461, 4787], 'be': [3488, 4788], 'positively': [3489], 'regulated': [3490], 'pathophysiologically': [3497, 4772], 'relevant': [3498], 'stimuli.': [3499], 'Activation': [3501], 'Promoter—To': [3505], 'determine': [3506, 4292], 'consequence': [3509], 'endogenous': [3514], 'co-transfection': [3525], 'pCB6-Egr-1,': [3530], 'generates': [3532], 'exogenous': [3533], '4).': [3536, 3551, 3571], 'pCB6-Egr-1': [3537, 3559], '>5-fold': [3542], 'backbone,': [3547], 'pCB6,': [3548], 'alone': [3549, 4244], 'difference': [3555], 'co-transfected': [3563], 'pGL3-basic,': [3565], 'empty': [3567], 'Induces': [3573, 3859, 4248], 'SMCs—FGF-2': [3580], 'key': [3583, 4684], 'mediator': [3584], 'differentiation': [3589], 'physiological': [3591], '(25Ornitz': [3595], 'D.M.': [3596], 'Itoh': [3597], 'Genome': [3599], '(http://genomebiology.com/2001/2/3/REVIEWS/3005)PubMed': [3602], 'Previously,': [3605], '(26Santiago': [3618, 4363], 'Day': [3622, 4367, 4630], '154:': [3632, 4377, 4640], '937-944Scopus': [3633, 4378, 4641], '(111)': [3634, 4379, 4642], 'therefore': [3638, 4382], 'postulated': [3639], 'Egr-1-dependent': [3643], 'activation.': [3645], 'Serum-starved': [3646, 4113], '(25': [3652, 3812, 3877, 4191, 4311, 4321], 'ng/ml)': [3653, 3813, 3878, 4192], 'various': [3655], 'times': [3656], 'assessment': [3660], 'steady-state': [3662], 'levels': [3664, 3707, 3716, 3729, 3921, 4026], 'semiquantitative': [3666], '5).': [3671], 'increased': [3675, 3999], 'response': [3677], 'manner,': [3683], 'maximally': [3684, 3697], '5,': [3689, 3712, 3724], 'top': [3690], 'section).': [3691, 3714, 3726], 'returning': [3704], 'basal': [3706, 3731], 'middle': [3713], 'β-Actin': [3715], 'unbiased': [3718], 'loading': [3719], 'samples': [3722], 'bottom': [3725], 'Interestingly,': [3727], 'low': [3728], 'absence': [3736], 'coincide': [3739], 'weak': [3741, 3952], '5)': [3745], '6).': [3757, 3892, 3910, 3929, 3950], 'findings,': [3759, 4346], 'illustrate': [3761], 'tight': [3763], 'temporal': [3764], 'relationship': [3765], 'expression,': [3770, 4299], 'time': [3775], 'agonist': [3780], 'expression.Fig.': [3783], '6Induction': [3784], 'DNA-binding': [3787], 'FGF-2.': [3790], '(NE)': [3803], 'serum-starved': [3805, 4302], 'Complexes': [3819], 'N1–N6': [3820, 3890], 'arrows.': [3824], 'demonstrates': [3827], 'specificity': [3829], 'FGF-2-induced': [3832], '(IND)': [3835], 'corrected': [3841], 'assay.': [3847], 'α,': [3848], 'antibody.View': [3849], 'Large': [3850], 'Image': [3851], 'Figure': [3852], 'ViewerDownload': [3853], 'Hi-res': [3854], 'image': [3855], 'Download': [3856], '(PPT)': [3857], 'SMCs—EMSA': [3868], 'Of': [3893], 'these,': [3894], 'only': [3895], 'one': [3896], '(N3)': [3898], 'transiently': [3900, 4584], '6,': [3903], 'IND)': [3904], 'upon': [3905, 4018, 4454], 'exposure': [3906], 'Complex': [3911], 'clearly': [3914], 'within': [3916, 3923], 'h;': [3918], 'then': [3919, 3986], 'intensity': [3920, 3953], 'fell': [3922], 'subsequent': [3925], 'eliminated': [3938], '6)': [3944], 'reflects': [3963], 'use': [3965, 4671], 'growth-quiescent': [3969], '(unstimulated)': [3970], 'SMCs.': [3971], 'indicate': [3974], 'synthesis': [3979], 'accumulation': [3982], 'translocates': [3987], 'nucleus': [3990], 'coincident': [3997], 'Block': [4004], 'Expression—To': [4008], 'directly': [4009], 'establish': [4010], 'whether': [4011], 'critically': [4016], 'dependent': [4017], 'assessed': [4024], 'previously': [4031, 4048], 'transfected': [4033, 4116, 4205, 4219], 'ED5.': [4038, 4186], 'sequence-specific': [4041], '"gene': [4042], 'knock-down"': [4043], 'agents,': [4044], 'inhibit': [4050], 'neointima': [4051, 4398], 'carotid': [4055], 'arteries': [4056, 4088], 'after': [4057], 'balloon': [4058], 'pig': [4086], 'coronary': [4087], 'following': [4089], 'stenting': [4090], '(28Lowe': [4091], 'Fahmy': [4093], 'R.G.': [4094], '89:': [4106], '670-677Crossref': [4107], 'ED5': [4119, 4207], 'targets': [4145], 'cleaves': [4147], 'translational': [4149], 'ED5SCR,': [4181], 'counterpart': [4184], 'treatment': [4188, 4318, 4792], 'h,': [4195], '7).': [4209, 4227, 4246], 'still': [4215], 'ED5SCR': [4221], 'latter': [4232], 'did': [4234], 'differ': [4236], 'stimulated': [4241], 'via': [4250, 4571], 'Not': [4254], 'Signaling': [4257], 'Pathway—FGF-2-induced': [4258], 'signal': [4259], 'transduction': [4260], 'known': [4262], 'involve': [4264], 'kinases': [4271], 'JNK.': [4276], 'pathways': [4278], 'fundamental': [4283], 'cellular': [4284], 'proliferation,': [4287], 'differentiation,': [4288], 'survival.': [4290], 'pathway': [4295], 'mediating': [4296], 'SMC': [4303, 4423, 4434], 'μm)': [4308], 'nm)': [4312], 'ng/ml).': [4322], 'blocked': [4328], 'MEK/ERK': [4331], 'inhibitor': [4332, 4341], '8)': [4335], '8).': [4344], 'consistent': [4347], 'our': [4349], 'previous': [4350], 'demonstration': [4351], 'through': [4357, 4669], 'specific': [4359], 'involvement': [4385], 'ERK-Egr-1': [4388], 'axis': [4389], 'disorders': [4402], 'phenotype.': [4424], 'constitutively': [4431], 'endothelial': [4436], 'diseased': [4442], 'artery': [4443, 4489], 'serve': [4446], 'reservoirs': [4448], 'mitogens': [4450], 'released': [4453], 'injury.': [4456], 'release': [4458], 'trigger': [4462], 'mitogens,': [4467], 'thereby': [4468], 'starting': [4469], 'cascade': [4471], 'autocrine/paracrine': [4473], 'consequential': [4476], 'intimal': [4477], 'thickening.': [4478], 'chain': [4481], 'study,': [4560, 4668], 'demonstrated': [4563], 'ERK-dependent': [4573], 'itself': [4581], 'rapidly': [4582], '26Santiago': [4626], '29Lowe': [4645], 'Hopkins': [4649], 'A.P.': [4650], 'Juergens': [4651], 'C.P.': [4652], 'Haemostasis.': [4656], '85:': [4658], '574-576Crossref': [4659], '(13)': [4662], 'As': [4665], 'such,': [4666], 'agonists,': [4673], 'overexpression,': [4674], 'novel': [4676], 'knockdown': [4677], 'approaches,': [4678], 'insights': [4685], 'regulating': [4690], 'It': [4697], 'points': [4699], 'regions': [4710], '(bp': [4714], '–76': [4715], 'how': [4725], 'theme': [4731], 'promoters,': [4735], 'it': [4737], 'those': [4740], 'PDGF-B,': [4742], 'u-PA,': [4743], 'PAI-1,': [4744], '(15Khachigian': [4748], 'ability': [4768], 'activate': [4770], 'involved': [4775], 'growth,': [4778], 'migration,': [4779], 'adhesion,': [4781], 'coagulation,': [4783], 'strategies': [4784], 'useful': [4789], 'prevention': [4794]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2044643825', 'counts_by_year': [{'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2025-01-04T23:14:49.523034', 'created_date': '2016-06-24'}