Title: Hydroxyl radical scavenging activity of compatible solutes
Abstract: Compatible solutes were assessed for their hydroxyl radical scavenging activity by their ability to compete in two different hydroxyl radical generating and detecting systems. Hydroxyl radicals were generated by ascorbate-hydrogen peroxide or by xanthine oxidase-hypoxanthine-hydrogen peroxide. They were detected by hydroxylation of salicylate or by denaturation of malate dehydrogenase. Of the compatible solutes tested, sorbitol, mannitol, myo-inositol and proline were effective hydroxyl radical scavengers. Glycinebetaine was ineffective. The role of compatible solutes as hydroxyl radical scavengers in vivo is discussed.
Publication Year: 1989
Publication Date: 1989-01-01
Language: en
Type: article
Indexed In: ['crossref']
Access and Citation
Cited By Count: 2030
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