Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2044296849', 'doi': 'https://doi.org/10.1073/pnas.1306621110', 'title': 'Pathogenetic mechanisms of amyloid A amyloidosis', 'display_name': 'Pathogenetic mechanisms of amyloid A amyloidosis', 'publication_year': 2013, 'publication_date': '2013-08-19', 'ids': {'openalex': 'https://openalex.org/W2044296849', 'doi': 'https://doi.org/10.1073/pnas.1306621110', 'mag': '2044296849', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/23959890', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3791773'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.1306621110', 'pdf_url': 'https://www.pnas.org/content/pnas/110/40/16115.full.pdf', 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.pnas.org/content/pnas/110/40/16115.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5070611649', 'display_name': 'Paul Simons', 'orcid': 'https://orcid.org/0000-0002-5007-6674'}, 'institutions': [{'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'J. Paul Simons', 'raw_affiliation_strings': ['Centre for Biomedical Science, Division of Medicine, University College London, London NW3 2PF, United Kingdom;', 'Wolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, University College London, London NW3 2PF, United Kingdom;'], 'affiliations': [{'raw_affiliation_string': 'Wolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, University College London, London NW3 2PF, United Kingdom;', 'institution_ids': ['https://openalex.org/I45129253']}, {'raw_affiliation_string': 'Centre for Biomedical Science, Division of Medicine, University College London, London NW3 2PF, United Kingdom;', 'institution_ids': ['https://openalex.org/I45129253']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071565068', 'display_name': 'Raya Al‐Shawi', 'orcid': 'https://orcid.org/0000-0002-9174-8924'}, 'institutions': [{'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Raya Al-Shawi', 'raw_affiliation_strings': ['bCentre for Biomedical Science, Division of Medicine, University College London, London NW3 2PF, United Kingdom;'], 'affiliations': [{'raw_affiliation_string': 'bCentre for Biomedical Science, Division of Medicine, University College London, London NW3 2PF, United Kingdom;', 'institution_ids': ['https://openalex.org/I45129253']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026476915', 'display_name': 'Stephan Ellmerich', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Stephan Ellmerich', 'raw_affiliation_strings': ['aWolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, University College London, London NW3 2PF, United Kingdom;'], 'affiliations': [{'raw_affiliation_string': 'aWolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, University College London, London NW3 2PF, United Kingdom;', 'institution_ids': ['https://openalex.org/I45129253']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040495824', 'display_name': 'Ivana Speck', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Ivana Speck', 'raw_affiliation_strings': ['aWolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, University College London, London NW3 2PF, United Kingdom;'], 'affiliations': [{'raw_affiliation_string': 'aWolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, University College London, London NW3 2PF, United Kingdom;', 'institution_ids': ['https://openalex.org/I45129253']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090834591', 'display_name': 'Samrina Aslam', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Samrina Aslam', 'raw_affiliation_strings': ['bCentre for Biomedical Science, Division of Medicine, University College London, London NW3 2PF, United Kingdom;'], 'affiliations': [{'raw_affiliation_string': 'bCentre for Biomedical Science, Division of Medicine, University College London, London NW3 2PF, United Kingdom;', 'institution_ids': ['https://openalex.org/I45129253']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017224460', 'display_name': 'W L Hutchinson', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Winston L. Hutchinson', 'raw_affiliation_strings': ['aWolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, University College London, London NW3 2PF, United Kingdom;'], 'affiliations': [{'raw_affiliation_string': 'aWolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, University College London, London NW3 2PF, United Kingdom;', 'institution_ids': ['https://openalex.org/I45129253']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065863330', 'display_name': 'P. Patrizia Mangione', 'orcid': 'https://orcid.org/0000-0003-0260-1400'}, 'institutions': [{'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}, {'id': 'https://openalex.org/I25217355', 'display_name': 'University of Pavia', 'ror': 'https://ror.org/00s6t1f81', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I25217355']}], 'countries': ['GB', 'IT'], 'is_corresponding': False, 'raw_author_name': 'Palma P. Mangione', 'raw_affiliation_strings': ['aWolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, University College London, London NW3 2PF, United Kingdom;', 'cDepartment of Molecular Medicine, University of Pavia, 27100 Pavia, Italy;'], 'affiliations': [{'raw_affiliation_string': 'aWolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, University College London, London NW3 2PF, United Kingdom;', 'institution_ids': ['https://openalex.org/I45129253']}, {'raw_affiliation_string': 'cDepartment of Molecular Medicine, University of Pavia, 27100 Pavia, Italy;', 'institution_ids': ['https://openalex.org/I25217355']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033429886', 'display_name': 'Petra Disterer', 'orcid': 'https://orcid.org/0000-0001-9702-9974'}, 'institutions': [{'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Petra Disterer', 'raw_affiliation_strings': ['dCentre for Neuroendocrinology, Division of Medicine, University College London, London NW3 2PF, United Kingdom; and'], 'affiliations': [{'raw_affiliation_string': 'dCentre for Neuroendocrinology, Division of Medicine, University College London, London NW3 2PF, United Kingdom; and', 'institution_ids': ['https://openalex.org/I45129253']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050123012', 'display_name': 'Janet A. Gilbertson', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Janet A. Gilbertson', 'raw_affiliation_strings': ['aWolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, University College London, London NW3 2PF, United Kingdom;'], 'affiliations': [{'raw_affiliation_string': 'aWolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, University College London, London NW3 2PF, United Kingdom;', 'institution_ids': ['https://openalex.org/I45129253']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086022732', 'display_name': 'Toby Hunt', 'orcid': 'https://orcid.org/0000-0001-8377-0841'}, 'institutions': [{'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Toby Hunt', 'raw_affiliation_strings': ['aWolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, University College London, London NW3 2PF, United Kingdom;'], 'affiliations': [{'raw_affiliation_string': 'aWolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, University College London, London NW3 2PF, United Kingdom;', 'institution_ids': ['https://openalex.org/I45129253']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101462032', 'display_name': 'David J. Millar', 'orcid': 'https://orcid.org/0000-0002-1555-6365'}, 'institutions': [{'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'David J. Millar', 'raw_affiliation_strings': ['aWolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, University College London, London NW3 2PF, United Kingdom;'], 'affiliations': [{'raw_affiliation_string': 'aWolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, University College London, London NW3 2PF, United Kingdom;', 'institution_ids': ['https://openalex.org/I45129253']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005804923', 'display_name': 'Shane Minogue', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Shane Minogue', 'raw_affiliation_strings': ['eInstitute of Liver and Digestive Health, Division of Medicine, University College London, London NW3 2PF, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'eInstitute of Liver and Digestive Health, Division of Medicine, University College London, London NW3 2PF, United Kingdom', 'institution_ids': ['https://openalex.org/I45129253']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091331212', 'display_name': 'Karl Bodin', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Karl Bodin', 'raw_affiliation_strings': ['aWolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, University College London, London NW3 2PF, United Kingdom;'], 'affiliations': [{'raw_affiliation_string': 'aWolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, University College London, London NW3 2PF, United Kingdom;', 'institution_ids': ['https://openalex.org/I45129253']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079554246', 'display_name': 'Mark B. Pepys', 'orcid': 'https://orcid.org/0000-0003-2614-3248'}, 'institutions': [{'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Mark B. Pepys', 'raw_affiliation_strings': ['aWolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, University College London, London NW3 2PF, United Kingdom;'], 'affiliations': [{'raw_affiliation_string': 'aWolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, University College London, London NW3 2PF, United Kingdom;', 'institution_ids': ['https://openalex.org/I45129253']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5033490022', 'display_name': 'Philip N. Hawkins', 'orcid': 'https://orcid.org/0000-0002-6983-9598'}, 'institutions': [{'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Philip N. Hawkins', 'raw_affiliation_strings': ['aWolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, University College London, London NW3 2PF, United Kingdom;'], 'affiliations': [{'raw_affiliation_string': 'aWolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, University College London, London NW3 2PF, United Kingdom;', 'institution_ids': ['https://openalex.org/I45129253']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 4.051, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 94, 'citation_normalized_percentile': {'value': 0.999986, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '110', 'issue': '40', 'first_page': '16115', 'last_page': '16120'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11305', 'display_name': 'Molecular Mechanisms of Amyloidosis', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11305', 'display_name': 'Molecular Mechanisms of Amyloidosis', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10760', 'display_name': 'Diagnosis and Management of Pancreatitis', 'score': 0.9807, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10915', 'display_name': 'Copper and Zinc in Health and Disease', 'score': 0.9788, 'subfield': {'id': 'https://openalex.org/subfields/2916', 'display_name': 'Nutrition and Dietetics'}, 'field': {'id': 'https://openalex.org/fields/29', 'display_name': 'Nursing'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/amyloid', 'display_name': 'Amyloid (mycology)', 'score': 0.73662734}, {'id': 'https://openalex.org/keywords/aa-amyloidosis', 'display_name': 'AA amyloidosis', 'score': 0.5825585}, {'id': 'https://openalex.org/keywords/cardiac-amyloidosis', 'display_name': 'Cardiac Amyloidosis', 'score': 0.514814}, {'id': 'https://openalex.org/keywords/amyloid-disease', 'display_name': 'Amyloid disease', 'score': 0.43696928}], 'concepts': [{'id': 'https://openalex.org/C55359608', 'wikidata': 'https://www.wikidata.org/wiki/Q3113038', 'display_name': 'Serum amyloid A', 'level': 3, 'score': 0.8693681}, {'id': 'https://openalex.org/C2779951007', 'wikidata': 'https://www.wikidata.org/wiki/Q816798', 'display_name': 'Amyloidosis', 'level': 2, 'score': 0.8647095}, {'id': 'https://openalex.org/C2777633098', 'wikidata': 'https://www.wikidata.org/wiki/Q2736051', 'display_name': 'Amyloid (mycology)', 'level': 2, 'score': 0.73662734}, {'id': 'https://openalex.org/C2910060150', 'wikidata': 'https://www.wikidata.org/wiki/Q3113038', 'display_name': 'Serum Amyloid A Protein', 'level': 4, 'score': 0.63100606}, {'id': 'https://openalex.org/C2777007455', 'wikidata': 'https://www.wikidata.org/wiki/Q2844591', 'display_name': 'AA amyloidosis', 'level': 4, 'score': 0.5825585}, {'id': 'https://openalex.org/C2780029684', 'wikidata': 'https://www.wikidata.org/wiki/Q14891716', 'display_name': 'Serum amyloid P component', 'level': 4, 'score': 0.56136554}, {'id': 'https://openalex.org/C57194454', 'wikidata': 'https://www.wikidata.org/wiki/Q424211', 'display_name': 'Acute-phase protein', 'level': 3, 'score': 0.5410203}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.53138393}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.50202155}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.48857936}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.46615967}, {'id': 'https://openalex.org/C2909607560', 'wikidata': 'https://www.wikidata.org/wiki/Q6740853', 'display_name': 'Amyloid disease', 'level': 5, 'score': 0.43696928}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.32526076}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.29180655}, {'id': 'https://openalex.org/C2994168385', 'wikidata': 'https://www.wikidata.org/wiki/Q6740853', 'display_name': 'Amyloid fibril', 'level': 4, 'score': 0.19848838}, {'id': 'https://openalex.org/C2781195455', 'wikidata': 'https://www.wikidata.org/wiki/Q422766', 'display_name': 'C-reactive protein', 'level': 3, 'score': 0.17274973}, {'id': 'https://openalex.org/C2779537928', 'wikidata': 'https://www.wikidata.org/wiki/Q1144618', 'display_name': 'Familial Mediterranean fever', 'level': 3, 'score': 0.11704072}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.07568875}, {'id': 'https://openalex.org/C3019447875', 'wikidata': 'https://www.wikidata.org/wiki/Q417667', 'display_name': 'Amyloid β', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000682', 'descriptor_name': 'Amyloid', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000686', 'descriptor_name': 'Amyloidosis', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': True}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': 'Q000150', 'qualifier_name': 'complications', 'is_major_topic': True}, {'descriptor_ui': 'D000685', 'descriptor_name': 'Serum Amyloid A Protein', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000682', 'descriptor_name': 'Amyloid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000686', 'descriptor_name': 'Amyloidosis', 'qualifier_ui': 'Q000209', 'qualifier_name': 'etiology', 'is_major_topic': False}, {'descriptor_ui': 'D000686', 'descriptor_name': 'Amyloidosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003224', 'descriptor_name': 'Congo Red', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017931', 'descriptor_name': 'DNA Primers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017931', 'descriptor_name': 'DNA Primers', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D004318', 'descriptor_name': 'Doxycycline', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004318', 'descriptor_name': 'Doxycycline', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008822', 'descriptor_name': 'Mice, Transgenic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D060888', 'descriptor_name': 'Real-Time Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000685', 'descriptor_name': 'Serum Amyloid A Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 6, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.1306621110', 'pdf_url': 'https://www.pnas.org/content/pnas/110/40/16115.full.pdf', 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3791773', 'pdf_url': 'https://europepmc.org/articles/pmc3791773?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791773', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://discovery.ucl.ac.uk/id/eprint/1405077/', 'pdf_url': 'https://discovery.ucl.ac.uk/1405077/1/Simons%20et%20al%20Pathogenesis%20of%20AA%20amyloidosis%20PNAS%202013.pdf', 'source': {'id': 'https://openalex.org/S4306400024', 'display_name': 'UCL Discovery (University College London)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I45129253', 'host_organization_name': 'University College London', 'host_organization_lineage': ['https://openalex.org/I45129253'], 'host_organization_lineage_names': ['University College London'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://discovery.ucl.ac.uk/id/eprint/1405077/1/Simons%20et%20al%20Pathogenesis%20of%20AA%20amyloidosis%20PNAS%202013.pdf', 'pdf_url': 'https://discovery.ucl.ac.uk/id/eprint/1405077/1/Simons%20et%20al%20Pathogenesis%20of%20AA%20amyloidosis%20PNAS%202013.pdf', 'source': {'id': 'https://openalex.org/S4306400024', 'display_name': 'UCL Discovery (University College London)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I45129253', 'host_organization_name': 'University College London', 'host_organization_lineage': ['https://openalex.org/I45129253'], 'host_organization_lineage_names': ['University College London'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/23959890', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.1306621110', 'pdf_url': 'https://www.pnas.org/content/pnas/110/40/16115.full.pdf', 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.71, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 42, 'referenced_works': ['https://openalex.org/W122337325', 'https://openalex.org/W1549265997', 'https://openalex.org/W1648126347', 'https://openalex.org/W1966937637', 'https://openalex.org/W1970879906', 'https://openalex.org/W1971610653', 'https://openalex.org/W1978475423', 'https://openalex.org/W1979614249', 'https://openalex.org/W1990912960', 'https://openalex.org/W1992251016', 'https://openalex.org/W2006058954', 'https://openalex.org/W2031920531', 'https://openalex.org/W2035391976', 'https://openalex.org/W2040675166', 'https://openalex.org/W2041895471', 'https://openalex.org/W2047948719', 'https://openalex.org/W2059846562', 'https://openalex.org/W2062003017', 'https://openalex.org/W2076467891', 'https://openalex.org/W2076807370', 'https://openalex.org/W2082024708', 'https://openalex.org/W2082800836', 'https://openalex.org/W2094274295', 'https://openalex.org/W2103402325', 'https://openalex.org/W2105290019', 'https://openalex.org/W2107911925', 'https://openalex.org/W2114159444', 'https://openalex.org/W2122605756', 'https://openalex.org/W2134735862', 'https://openalex.org/W2136477387', 'https://openalex.org/W2142322879', 'https://openalex.org/W2150420004', 'https://openalex.org/W2150712887', 'https://openalex.org/W2152565550', 'https://openalex.org/W2170626707', 'https://openalex.org/W2185194418', 'https://openalex.org/W2294568590', 'https://openalex.org/W2397183436', 'https://openalex.org/W2419049056', 'https://openalex.org/W4210576276', 'https://openalex.org/W4210660926', 'https://openalex.org/W4252997515'], 'related_works': ['https://openalex.org/W4310051484', 'https://openalex.org/W38259661', 'https://openalex.org/W2414084021', 'https://openalex.org/W2323655508', 'https://openalex.org/W2186899866', 'https://openalex.org/W2103402325', 'https://openalex.org/W2085236894', 'https://openalex.org/W2073875187', 'https://openalex.org/W1978604713', 'https://openalex.org/W144846707'], 'abstract_inverted_index': {'Systemic': [0], 'amyloid': [1, 26, 66, 78, 143, 175, 185, 224], 'A': [2], '(AA)': [3], 'amyloidosis': [4, 36, 92, 123, 133, 202, 210], 'is': [5, 21, 37, 80], 'a': [6, 97], 'serious': [7], 'complication': [8], 'of': [9, 43, 58, 71, 161, 169, 196, 206, 236, 243], 'chronic': [10], 'inflammation.': [11, 207], 'Serum': [12], 'AA': [13, 35, 65, 201, 209], 'protein': [14], '(SAA),': [15], 'an': [16], 'acute': [17, 204], 'phase': [18], 'plasma': [19, 152], 'protein,': [20], 'deposited': [22], 'extracellularly': [23], 'as': [24], 'insoluble': [25], 'fibrils': [27], 'that': [28, 64, 74], 'damage': [29], 'tissue': [30], 'structure': [31], 'and': [32, 73, 127, 141], 'function.': [33], 'Clinical': [34, 208], 'typically': [38], 'preceded': [39], 'by': [40, 82, 113], 'many': [41], 'years': [42], 'active': [44], 'inflammation': [45, 72], 'before': [46, 77], 'presenting,': [47], 'most': [48, 129], 'commonly': [49], 'with': [50, 159], 'renal': [51, 189, 197], 'involvement.': [52], 'Using': [53], 'dose-dependent,': [54], 'doxycycline-inducible': [55], 'transgenic': [56, 218], 'expression': [57, 90], 'SAA': [59, 85, 89, 102, 111, 119, 135, 153, 163, 170, 217], 'in': [60, 93, 199], 'mice,': [61], 'we': [62], 'show': [63], 'deposition': [67, 79, 144, 186], 'can': [68], 'occur': [69], 'independently': [70], 'the': [75, 83, 193, 213, 231, 233], 'time': [76], 'determined': [81], 'circulating': [84, 110], 'concentration.': [86, 154], 'High': [87], 'level': [88], 'induced': [91], 'all': [94, 177], 'mice': [95, 130, 178, 219], 'after': [96, 124, 165], 'short,': [98], 'slightly': [99], 'variable': [100], 'delay.': [101], 'was': [103], 'rapidly': [104], 'incorporated': [105], 'into': [106], 'amyloid,': [107], 'acutely': [108], 'reducing': [109], 'concentrations': [112], 'up': [114], 'to': [115, 151, 188, 228, 230], '90%.': [116], 'Prolonged': [117], 'modest': [118], 'overexpression': [120], 'occasionally': [121], 'produced': [122], 'long': [125], 'delays': [126], 'primed': [128], 'for': [131, 182, 241], 'explosive': [132], 'when': [134], 'production': [136, 164], 'subsequently': [137], 'increased.': [138], 'Endogenous': [139], 'priming': [140], 'bulk': [142], 'are': [145], 'thus': [146], 'separable': [147], 'events,': [148], 'each': [149], 'sensitive': [150], 'Amyloid': [155], 'deposits': [156], 'slowly': [157], 'regressed': [158], 'restoration': [160], 'normal': [162], 'doxycycline': [166], 'withdrawal.': [167], 'Reinduction': [168], 'overproduction': [171], 'revealed': [172], 'that,': [173], 'following': [174, 203], 'regression,': [176], 'were': [179], 'primed,': [180], 'especially': [181], 'rapid': [183, 194], 'glomerular': [184], 'leading': [187], 'failure,': [190], 'closely': [191], 'resembling': [192], 'onset': [195], 'failure': [198], 'clinical': [200], 'exacerbation': [205], 'rarely': [211], 'involves': [212], 'heart,': [214], 'but': [215], 'amyloidotic': [216], 'consistently': [220], 'had': [221], 'minor': [222], 'cardiac': [223], 'deposits,': [225], 'enabling': [226], 'us': [227], 'extend': [229], 'heart': [232], 'demonstrable': [234], 'efficacy': [235], 'our': [237], 'unique': [238], 'antibody': [239], 'therapy': [240], 'elimination': [242], 'visceral': [244], 'amyloid.': [245]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2044296849', 'counts_by_year': [{'year': 2024, 'cited_by_count': 7}, {'year': 2023, 'cited_by_count': 9}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 9}, {'year': 2019, 'cited_by_count': 10}, {'year': 2018, 'cited_by_count': 10}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 10}, {'year': 2015, 'cited_by_count': 11}, {'year': 2014, 'cited_by_count': 8}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-09-18T06:42:12.494559', 'created_date': '2016-06-24'}