Publication Information

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5422, 5438], 'most': [9, 229, 780, 1130, 1596, 1859, 1896, 4211], 'important': [10, 66, 230, 286, 1860, 3535, 4212, 4471, 4555, 5367], 'effects': [11, 212, 231, 432, 1331, 1650, 1848, 2047, 4214], 'type': [13, 39, 87, 128, 134, 196, 214, 233, 259, 307, 348, 354, 416, 434, 1187, 1437, 1645, 1661, 1850, 1924, 1930, 2005, 2049, 2063, 2664, 2727, 2753, 2883, 2912, 3157, 3201, 3205, 3260, 3325, 3436, 3477, 3521, 3658, 3692, 3725, 3834, 4150, 4216, 4379, 4410, 4561, 4574, 4588, 4597, 4661, 4682, 4746, 4776, 4967, 5159, 5180, 5229, 5264, 5272, 5378], 'I': [14, 40, 88, 135, 197, 215, 234, 260, 308, 355, 417, 435, 1029, 1188, 1269, 1438, 1646, 1662, 1851, 1925, 1931, 2006, 2050, 2645, 2665, 2728, 2884, 3158, 3169, 3202, 3326, 3478, 3502, 3522, 3659, 3693, 4151, 4217, 4380, 4411, 4562, 4589, 4662, 4683, 4747, 4777, 4968, 5160, 5181, 5230, 5265, 5273, 5379], 'interferons': [15, 235, 1030], '(IFNs).': [16, 236], 'This': [17, 237, 3221, 3262, 4370], 'response': [18, 37, 164, 238, 257, 384, 1261, 1921, 1988, 2543, 2719, 3223, 3558, 3591, 3656, 3999, 4408, 4680, 4749, 4761, 4779], 'may': [19, 239, 4131, 4445, 4827, 5408], 'involve': [20, 240, 1448], 'a': [21, 146, 241, 366, 642, 761, 1116, 1235, 1449, 1819, 1835, 1986, 2012, 2038, 2143, 2414, 2426, 2614, 2618, 2760, 2831, 3226, 3364, 3589, 3604, 3654, 3689, 3697, 4534, 4634, 4758, 4829, 4946, 4957, 4971, 5029, 5256, 5387], 'cytostatic': [22, 209, 242, 429, 1450, 1987, 2046, 3227, 3290, 3470, 4227, 5156, 5261], 'effect': [23, 58, 85, 132, 170, 243, 278, 305, 352, 390, 1346, 1399, 1451, 1611, 1982, 2662, 3199, 3295, 3323, 3475, 3519, 3539, 3566, 3898, 4451, 4559, 4659, 4930, 5010, 5036, 5052, 5103, 5127, 5157, 5178, 5262, 5440], 'or': [24, 115, 155, 244, 335, 375, 601, 603, 658, 704, 797, 799, 804, 811, 1452, 1624, 1679, 1831, 1960, 2324, 2485, 3122, 3181, 3249, 3280, 3330, 3338, 3349, 3418, 3486, 3493, 3514, 3669, 3715, 3770, 3785, 3856, 4228, 4543, 4551, 4652, 4670, 4704, 4769, 5028, 5110, 5166, 5170, 5201, 5389], 'induction': [26, 192, 246, 412, 1453, 1944, 2034, 2802, 2848, 2890, 2899, 2986, 3155, 3733, 3781, 3816, 3906, 3925, 4021, 4030, 4100, 4112, 4146, 4568, 4608, 4639, 4792, 4881, 4963, 5117, 5137, 5144, 5191], 'apoptosis': [28, 162, 194, 248, 382, 414, 703, 1455, 1770, 2010, 2036, 3429, 3620, 3676, 3695, 3880, 3927, 3997, 4023, 4148, 4944, 5193, 5241], 'depending': [29, 249, 1654], 'on': [30, 250, 1651, 1655, 3569, 5128, 5381], 'context.': [33, 253, 1658], 'Often': [34, 254], 'growth-inhibitory': [36, 57, 84, 131, 256, 277, 304, 351, 1398, 1981, 2718, 3198, 3222, 3294, 3322, 3474, 3518, 3538, 3655, 4558, 5051, 5439], 'IFNs': [41, 198, 216, 261, 418, 436, 1189, 1270, 1439, 1647, 1663, 1932, 2007, 2051, 2646, 2666, 2729, 2885, 3159, 3170, 3479, 3523, 3660, 4152, 4218, 4381, 4590, 4663, 4969, 5161, 5182, 5274, 5380, 5442], 'studied': [43, 263, 2451, 3564, 3731, 4566], 'in': [44, 82, 97, 103, 149, 163, 187, 264, 302, 317, 323, 369, 383, 407, 514, 654, 690, 809, 830, 1194, 1400, 1614, 1668, 1843, 1918, 1945, 1952, 1967, 2011, 2022, 2037, 2118, 2265, 2386, 2413, 2469, 2651, 2743, 2757, 2794, 2814, 2826, 2834, 2851, 2879, 2902, 2910, 2928, 2987, 3003, 3072, 3140, 3195, 3233, 3298, 3309, 3384, 3430, 3434, 3450, 3505, 3524, 3536, 3540, 3555, 3559, 3607, 3664, 3671, 3680, 3691, 3743, 3758, 3771, 3800, 3810, 3846, 3849, 3885, 3956, 3998, 4063, 4097, 4121, 4124, 4153, 4406, 4414, 4424, 4439, 4556, 4572, 4595, 4600, 4621, 4625, 4644, 4664, 4744, 4750, 4765, 4770, 4780, 4786, 4814, 4832, 4879, 4894, 4900, 4909, 4973, 5061, 5115, 5168, 5199, 5210, 5244, 5259, 5401, 5437], 'tumor': [45, 51, 265, 271, 794, 1615, 1621, 1821, 2677, 2699, 2732, 3283, 3531, 4001, 4421, 4475, 4974], 'lines': [47, 267, 1617, 1672, 2658, 3587, 4156, 4423], 'carrying': [48, 268], 'mutations': [49, 269, 808, 2740, 4540, 4581], 'suppressor': [52, 272, 1622, 2678, 2700], 'genes,': [53, 273, 2679, 4444], 'and': [54, 141, 168, 206, 210, 274, 361, 388, 426, 430, 701, 774, 840, 843, 1033, 1058, 1098, 1125, 1204, 1221, 1226, 1229, 1234, 1277, 1288, 1292, 1315, 1329, 1634, 1677, 1685, 1767, 1846, 1902, 1951, 1969, 1972, 2041, 2045, 2061, 2083, 2101, 2104, 2136, 2140, 2188, 2210, 2232, 2248, 2255, 2263, 2301, 2341, 2349, 2368, 2383, 2388, 2392, 2408, 2456, 2480, 2588, 2609, 2611, 2782, 2840, 3076, 3086, 3111, 3149, 3179, 3278, 3306, 3357, 3386, 3402, 3453, 3553, 3572, 3580, 3602, 3736, 3745, 3756, 3796, 3863, 3871, 3939, 4046, 4086, 4103, 4107, 4116, 4418, 4455, 4463, 4467, 4593, 4718, 4742, 5204, 5236, 5287, 5471, 5483, 5486], 'therefore,': [55, 275], 'can': [59, 279, 1447, 1664, 3303, 3661, 4711, 5275], 'be': [60, 280, 1394, 1640, 3372, 3534, 3662, 3949, 3965, 3973, 4446, 4554, 4728, 4763, 5251, 5435], 'influenced': [61, 281], 'by': [62, 174, 195, 282, 394, 415, 507, 589, 845, 1436, 1673, 1923, 1939, 1985, 2089, 2162, 2355, 2406, 2421, 2521, 2552, 2574, 2605, 2632, 2702, 2830, 2855, 3011, 3156, 3167, 3174, 3182, 3391, 3483, 3621, 3727, 3741, 3928, 3967, 4149, 4460, 4673, 4934, 4966, 5186, 5377], 'inactivation': [63, 283, 792, 3722], 'these': [65, 285, 1978, 2747, 3282, 3530, 4570, 4583, 5447], 'regulators': [67, 287, 5280, 5385], 'proliferation.': [70, 151, 290, 371], 'In': [71, 291, 1763, 1813, 1977], 'this': [72, 169, 292, 389, 664, 1814, 2731, 3335, 3915, 3945, 4035, 4430, 4806, 4887], 'report,': [73, 293], 'we': [74, 294, 1908, 2722, 2990, 3314, 3546, 3704, 3730, 4017, 4037, 4564, 4736, 5033], 'explored': [75, 295], 'role': [77, 297, 1854, 3190, 3550, 3690, 4722, 4739, 4831, 4876, 4972, 5112, 5258], 'ARF-p53': [80, 300, 1914, 2698, 3193, 4695], 'pathway': [81, 202, 301, 422, 758, 789, 1340, 1915, 2701, 3194, 3698, 4696, 5216], 'IFNs.': [89, 136, 309, 356, 1333, 1926, 2399, 3203, 4453, 4684, 5266], 'We': [90, 310, 1927, 3562, 3837, 4585, 5449], 'found': [91, 311, 1928, 4586], 'that': [92, 99, 110, 183, 203, 312, 319, 330, 403, 423, 652, 813, 1280, 1606, 1644, 1839, 1929, 2018, 2769, 2857, 2882, 2897, 2920, 2930, 3060, 3153, 3244, 3246, 3265, 3271, 3281, 3370, 3400, 3468, 3529, 3626, 3652, 3699, 3751, 3824, 3867, 3904, 4129, 4433, 4435, 4533, 4549, 4587, 4606, 4633, 4710, 4757, 4798, 4838, 4917, 4941, 4961, 5008, 5123, 5153, 5271], 'p53': [93, 313, 695, 1840, 1905, 1934, 1943, 2648, 2835, 2850, 2872, 2932, 2985, 3068, 3123, 3139, 3154, 3180, 3248, 3279, 3339, 3515, 3554, 3670, 3713, 3726, 3735, 3805, 3835, 4456, 4552, 4594, 4610, 4620, 4641, 4726, 4743, 4965, 5014, 5038, 5130, 5146, 5167, 5237], 'only': [95, 153, 315, 373, 679, 783, 3678, 5016, 5409], 'induced': [96, 316, 2772, 2877, 3010, 3426, 3876, 4813, 5243, 5376], 'cells': [98, 144, 318, 364, 815, 2158, 2378, 2468, 2482, 2929, 2993, 2997, 3002, 3142, 3151, 3235, 3245, 3360, 3432, 3449, 3541, 3575, 3598, 3614, 3634, 3707, 3761, 3848, 3983, 4624, 4768, 4783], 'express': [100, 320, 4904], 'p14ARF': [101, 160, 321, 380, 3008, 3134], '(p19ARF': [102, 322], 'mouse': [104, 107, 324, 327, 1052, 1092, 1947], 'cells).': [105, 325], 'Surprisingly,': [106, 326, 1993, 3917, 4647, 4774], 'embryonal': [108, 328, 1053, 1093, 1948], 'fibroblasts': [109, 329, 1949], 'are': [111, 331, 636, 1207, 2639, 2681, 2713, 2925, 3268, 3285, 3377, 3806, 4094, 4436, 4457, 4707, 5207, 5386, 5390, 5450], 'null': [112, 332, 1954, 3340, 3488], 'for': [113, 333, 638, 764, 1209, 1326, 1343, 1396, 2032, 2222, 2305, 2431, 2531, 2540, 2566, 2580, 2585, 2591, 2846, 2863, 2888, 2984, 3273, 3288, 3516, 3873, 3914, 3944, 3981, 4052, 4144, 4375, 4382, 4429, 4448, 4637, 4700, 4713, 4805, 5134, 5393, 5421, 5430, 5479], 'p19ARF': [114, 334, 841, 2244, 2770, 2804, 2827, 2845, 2878, 2887], 'P53,': [116, 336], 'even': [117, 337, 3419, 3809, 4419, 5233], 'after': [118, 338, 2777, 3215, 3603, 3638, 4042, 4819, 5228], 'transformation': [119, 339, 581, 3319, 4667], 'with': [120, 158, 340, 378, 1317, 1599, 1618, 1998, 2126, 2337, 2394, 2446, 2484, 2490, 2861, 2994, 3102, 3147, 3184, 3217, 3254, 3344, 3354, 3406, 3439, 3460, 3643, 3765, 3773, 3788, 3869, 3934, 4025, 4048, 4817, 4952, 5023], 'oncogenic': [121, 341, 1897, 2686, 2703, 3301, 3382, 3407, 3457, 3484, 4461, 4674, 5187], 'RAS,': [122, 342, 771], 'respond': [123, 343, 3251, 3409], 'as': [124, 126, 344, 346, 770, 1218, 1900, 1937, 2027, 2259, 2613, 2641, 2670, 2907, 2909, 3258, 3363, 3415, 3417, 3978, 4139, 4442, 5282], 'well': [125, 345, 3416], 'wild': [127, 347, 2752, 2911, 3259, 3435, 3724, 3833, 4573, 4596], 'to': [129, 165, 349, 385, 504, 696, 816, 828, 1190, 1251, 1264, 1282, 1393, 1608, 1642, 1910, 2008, 2332, 2569, 2659, 2671, 2706, 2724, 2999, 3063, 3132, 3225, 3252, 3366, 3410, 3500, 3592, 3657, 3923, 3995, 4000, 4409, 4531, 4576, 4618, 4681, 4924, 5048, 5250, 5434, 5445, 5452], 'Similarly,': [137, 357, 4614], 'human': [138, 358, 1045, 1085, 1955, 1973, 2541, 2988, 3007, 3560, 3585, 3672, 3986, 4622, 4645, 4751, 5024, 5171, 5245], 'ARF–/–': [139, 359, 1946, 1974, 1996, 2084, 2858, 3307, 3329, 3385, 3401, 3452, 4601, 4669, 4771, 4787], 'U2OS': [140, 156, 360, 376, 1956, 1975, 1997, 2481, 3001, 3570, 4047, 4772, 4788, 4818, 5200], 'P53–/–': [142, 362, 2082, 3305, 3331, 3387, 3403, 3454, 4671, 4766], 'SAOS-2': [143, 154, 363, 374, 2479, 3141, 3573, 3597, 3630, 3682, 4045, 4106, 4122, 4767, 4782, 4815, 4901, 5202], 'show': [145, 365, 3211], 'significant': [147, 367, 3081, 3212, 3231, 4759], 'decrease': [148, 368], 'However,': [152, 372, 633, 2875, 3128, 4109, 4401, 5365], 'reconstituted': [157, 377], 'inducible': [159, 379, 2000], 'undergo': [161, 381, 3635, 5225], 'IFNβ': [166, 386, 1768, 1961, 3129, 3568, 3646, 3768, 3841, 3872, 3900, 3929, 3937, 4051, 4923, 5012, 5054, 5105], 'treatment,': [167, 387], 'was': [171, 391, 1916, 1983, 2353, 2419, 2450, 2476, 2502, 2603, 2828, 2853, 2894, 2905, 2981, 3130, 3236, 3389, 3615, 3677, 3912, 3919, 4118, 4372, 4616, 4697, 4803, 4931, 5015, 5242], 'not': [172, 392, 678, 782, 826, 1391, 1639, 1866, 2053, 2867, 2895, 2906, 3105, 3114, 3138, 3286, 3442, 3481, 3632, 3778, 3894, 4529, 4599, 4655, 4677, 4698, 4785, 4932, 4955, 5098, 5163, 5184, 5197, 5224, 5369], 'inhibited': [173, 393, 5185], 'expression': [175, 395, 1681, 2628, 2870, 3005, 3380, 4067, 4134, 4896, 5405], 'dominant': [177, 397, 3711, 4935], 'negative': [178, 398, 3712, 4936], 'p53.': [179, 399, 2892, 3494, 4544, 4719, 5119], 'These': [180, 400, 776, 2015, 3465, 3649, 4126, 4685, 4753], 'data': [181, 401, 3145, 3466, 3650, 4127, 4890, 4950, 5151], 'suggest': [182, 402, 3467, 3651, 4128], '(i)': [184, 404, 2019, 5154], 'at': [185, 405, 2020, 2308, 2381, 2442, 2465, 2563, 2786, 2789, 4886], 'least': [186, 406, 2021, 2443, 2466], 'specific': [188, 408, 1257, 1283, 1323, 2175, 2676], 'types,': [190, 410, 5219], 'requires': [199, 419, 3160, 5147, 5194], 'an': [200, 420, 1999, 2372, 2560, 4470, 4892, 5124, 5135, 5366, 5411], 'ARF': [201, 421, 812, 1953, 2003, 2029, 2650, 2901, 2924, 2980, 3121, 3178, 3250, 3277, 3337, 3492, 3495, 3513, 3552, 3579, 3668, 3687, 3742, 3954, 4130, 4454, 4542, 4550, 4592, 4628, 4651, 4717, 4724, 4741, 4802, 4878, 4921, 5114, 5165, 5195, 5235], 'p53-independent': [205, 425, 2013, 2039, 4947], '(ii)': [207, 427, 2042, 5175], 'pro-apoptotic': [211, 431, 4844], 'employ': [217, 437], 'different': [218, 438, 1649, 4386, 4688, 5044], 'pathways.': [219, 439], 'product': [441], 'retinoblastoma': [444], 'gene,': [445], 'RB': [446, 676, 788, 796], '(for': [447], 'recent': [448, 1836], 'reviews': [449], 'see': [450], 'Refs.': [451, 515], '1DiCiommo': [452, 516], 'D.': [453, 517, 609, 885, 972, 1509, 1525, 1577, 1581, 1694, 1714, 1718, 1754, 1804, 1875, 4284, 4300, 4352, 4356, 4983, 5077, 5296, 5316, 5320, 5356], 'Gallie': [454, 518, 610], 'B.L.': [455, 519, 611], 'Bremner': [456, 520, 612], 'R.': [457, 521, 613, 4197, 4863], 'Semin.': [458, 522, 614, 1144], 'Cancer': [459, 523, 615, 861, 938, 1006, 1145, 1481, 2167, 4256, 5475], 'Biol.': [460, 524, 616, 1146, 1382, 1590, 1727, 1776, 2077, 2152, 3052, 4365, 4502, 5329], '2000;': [461, 525, 617, 1015, 1147, 4480, 4522], '10:': [462, 526, 618, 1148, 1760, 4523, 5362], '255-269Google': [463, 527, 619], 'Scholar,': [464, 475, 486, 528, 539, 550, 562, 569, 620, 725, 744, 866, 879, 902, 927, 943, 962, 979, 991, 1011, 1018, 1150, 1168, 1303, 1355, 1376, 1474, 1486, 1497, 1517, 1530, 1541, 1560, 1573, 1699, 1710, 1731, 1742, 1781, 1792, 2960, 3041, 4179, 4249, 4261, 4272, 4292, 4305, 4316, 4335, 4348, 4483, 4495, 4506, 4513, 5301, 5312, 5333, 5344], '2Zheng': [465, 529], 'L.': [466, 530, 868, 881, 968], 'Lee': [467, 531, 965], 'W.-H.': [468, 532], 'Exp.': [469, 533, 1021, 1297, 1349, 4174], 'Cell': [470, 534, 1022, 1298, 1350, 1510, 1755, 1805, 2059, 2076, 2151, 2347, 3051, 4285, 4501, 5357], 'Res.': [471, 535, 862, 939, 1007, 1023, 1164, 1299, 1351, 1482, 4257], '2001;': [472, 536, 1008, 1384, 1427, 1778, 3053, 4503], '264:': [473, 537], '2-18Google': [474, 538], '3Lundberg': [476, 540], 'A.S.': [477, 541], 'Weinberg': [478, 542, 4486], 'R.A.': [479, 543, 872, 896, 949, 974, 983, 4487], 'Eur.': [480, 544], 'J.': [481, 492, 545, 556, 626, 870, 883, 929, 1156, 1161, 1381, 1467, 1488, 1492, 1503, 1555, 1568, 1748, 1775, 1783, 1787, 1798, 2075, 2150, 2361, 2956, 3037, 3047, 4173, 4183, 4203, 4242, 4263, 4267, 4278, 4330, 4343, 4849, 4869, 5350], 'Cancer.': [482, 546, 1493, 1569, 1788, 4268, 4344], '1999;': [483, 547, 863, 940, 988, 1165, 1300, 1352, 1471, 1759, 2973, 4246, 5361], '35:': [484, 548], '1886-1894Google': [485, 549], '4Sellers': [487, 551, 621], 'W.R.': [488, 552, 622], 'Kaelin': [489, 553, 623, 710], 'Jr.,': [490, 554, 624, 711], 'W.G.': [491, 555, 625, 712], 'Clin.': [493, 557, 627], 'Oncol.': [494, 558, 628], '1997;': [495, 559, 629, 899, 959, 1024, 1514, 1527, 1696, 1739, 1809, 4176, 4204, 4289, 4302, 4510, 4870, 5298, 5341], '15:': [496, 560, 630], '3301-3312Google': [497, 561, 631], 'Scholar),': [498, 1387], 'regulates': [499], 'passage': [501, 2796, 2799, 2816], 'from': [502, 2067, 2197, 2226, 2234, 2241, 2246, 2251, 2478, 2499, 2515, 3208], 'G1': [503, 1666], 'S': [505, 683], 'phase': [506, 684], 'tightly': [508], 'controlling': [509], 'restriction': [511, 587], 'point': [512, 588], '(reviewed': [513], '5Sherr': [563], 'C.J.': [564, 571, 860, 922, 951, 2968, 4515], 'Science.': [565], '1996;': [566, 976, 1373, 1591, 1728, 4366, 5330], '274:': [567], '1672-1677Google': [568], '6Sherr': [570], 'Proc.': [572, 715, 952, 1366, 1420, 4390], 'Assoc.': [573], 'Am.': [574], 'Physicians.': [575], '1995;': [576, 924, 1494, 1570, 1789, 4269, 4345], '107:': [577], '181-186Google': [578], 'Scholar).': [579, 632, 755, 1027, 1184, 1430, 1594, 1762, 1812, 1894, 2081, 2156, 2976, 3056, 4015, 4207, 4369, 4400, 4525, 4873, 5002, 5364], 'Malignant': [580], 'always': [582], 'involves': [583], 'deregulation': [584], 'either': [590, 791, 3120, 3266, 3345, 3451, 3491, 3512, 3710, 3882, 4225], 'absence': [592, 674, 1941, 3275, 3311, 3666, 3812, 3958, 4649, 4715], 'functional': [594, 3161], 'RB,': [595], 'amplification': [597, 800], 'cyclin': [599, 802, 1683, 5285], 'D': [600, 803], 'CDK4,': [602], 'loss': [605], 'p16INK4a': [607], '(1DiCiommo': [608], 'additional': [634], 'events': [635, 1605], 'required': [637, 1342, 1395, 2983, 3287, 4143, 4447, 4699], 'emergence': [640], 'malignant': [643], 'phenotype,': [644], 'because': [645, 1134, 1445, 2914, 3229, 3576, 3974, 5220], 'hyperproliferative': [646], 'signals': [647], 'trigger': [648], 'built-in': [649], 'safety': [650, 665, 762, 4472], 'mechanisms': [651, 777, 4230, 4709], 'result': [653, 3263], 'cycle': [656, 699, 819, 1632, 1828, 2708, 5279, 5384, 5416], 'arrest/senescence': [657], 'apoptosis.': [659, 822, 1635, 1992, 4833, 4926], 'main': [661], 'effector': [662], 'mechanism': [666, 4473, 4636], 'ARF-MDM2-p53': [669, 757], 'pathway.': [670, 2058, 2734, 4948], 'For': [671, 1659, 2311, 5003, 5397], 'instance,': [672], 'triggers': [677], 'transcription': [681, 1215, 1224, 1320], 'genes': [685, 1324, 1623, 2544, 4434, 5432], 'but': [686, 806, 3137, 4598], 'also': [687, 760, 807, 1271, 2714, 2982, 4755], 'p19ARF,': [688], 'which': [689, 836, 1122, 1206, 1249, 1628, 2680, 2712, 3004, 3963, 3991, 4141, 4626, 4903, 4912], 'turn': [691], 'inhibits': [692, 3827], 'MDM2,': [693], 'allowing': [694], 'stop': [697], 'progression': [700], 'induce': [702, 1272, 1665, 1769, 2009, 3133, 3843, 4591, 4619, 4925], 'senescence': [705], '(7Qin': [706], 'X.Q.': [707], 'Livingston': [708], 'D.M.': [709], 'Adams': [713], 'P.D.': [714], 'Natl.': [716, 953, 1367, 1421, 4391], 'Acad.': [717, 954, 1368, 1422, 4392], 'Sci.': [718, 875, 955, 1369, 1423, 4393], 'U.': [719, 956, 1370, 1424, 4394], 'S.': [720, 727, 852, 957, 1371, 1425, 1463, 1501, 1507, 1521, 1523, 1536, 1690, 1692, 1705, 1744, 1752, 1796, 1802, 1871, 1881, 2091, 2936, 2944, 3017, 3025, 3043, 4005, 4189, 4238, 4276, 4282, 4296, 4298, 4311, 4395, 4855, 4979, 4989, 5073, 5083, 5292, 5294, 5307, 5346, 5354, 5454], 'A.': [721, 958, 1372, 1426, 1459, 1465, 1587, 1724, 1869, 4181, 4193, 4234, 4240, 4362, 4396, 4847, 4859, 4977, 5071, 5326], '1994;': [722, 1557, 4332, 4397, 4492], '91:': [723, 4398], '10918-10922Google': [724], '8Bates': [726], 'Phillips': [728], 'A.C.': [729, 1380, 1733, 1774, 5335], 'Clark': [730, 3044], 'P.A.': [731, 3045], 'Stott': [732, 930], 'F.': [733, 914], 'Peters': [734, 934, 2165, 2953, 3034, 3048, 5473], 'G.': [735, 935, 1158, 1160, 1476, 2954, 3035, 3049, 4251, 5472], 'Ludwig': [736], 'R.L.': [737], 'Vousden': [738, 932, 2951, 3032], 'K.H.': [739, 933, 2952, 3033], 'Nature.': [740, 751, 1890, 4998, 5092], '1998;': [741, 752, 876, 1181, 1311, 1538, 1707, 2957, 3038, 4313, 5309], '395:': [742, 753], '124-125Google': [743], '9Palmero': [745], 'I.': [746, 1583, 1720, 2946, 3027, 4358, 5322], 'Pantoja': [747], 'C.': [748, 889, 891, 970, 1141, 1296, 1348, 2105, 4199, 4865, 5463], 'Serrano': [749], 'M.': [750, 887, 947, 964, 993, 1013, 1020, 1154, 1170, 1461, 1469, 1532, 1701, 1750, 2102, 2942, 3023, 4236, 4244, 4307, 4478, 5303, 5352, 5461], '125-126Google': [754], 'net': [763], 'activation': [766, 1196, 1389, 1625, 2695, 4692], 'oncogenes': [768], 'such': [769, 1899, 2026, 4138, 4441, 5281], 'MYC,': [772, 3313], 'v-Abl,': [773], 'E1A.': [775], 'explain': [778], 'why': [779], 'tumors': [781], 'have': [784, 1128, 1648, 4843], 'alterations': [785, 1619], '(i.e.': [790], 'suppressors': [795, 3284, 3532], 'INK4A,': [798], 'CDK4/6)': [805], 'P53': [810, 4653], 'allow': [814], 'escape': [817], 'arrest': [820, 1667, 2709], 'and/or': [821, 847, 2710, 4725], 'Thus,': [823], 'it': [824, 1255, 1446, 1637, 2915, 3971, 4527], 'surprising': [827, 1641, 2896, 4530], 'find': [829, 1643, 4532], 'many': [831], 'cancers': [832, 4538], 'INK4A': [834], 'locus,': [835], 'encodes': [837], 'both': [838, 3584], 'p16': [839], 'deleted': [842], 'inactivated': [844], 'methylation': [846], 'mutated': [848, 4438], '(10Kamijo': [849], 'T.': [850, 904, 995, 1478, 1505, 1800, 1885, 1889, 2360, 4253, 4280, 4993, 4997, 5087, 5091], 'Bodner': [851], 'van': [853], 'de': [854], 'Kamp': [855], 'E.': [856, 1001, 1152, 1407, 1480, 2950, 3031, 4255], 'Randle': [857], 'D.H.': [858], 'Sherr': [859, 921, 950, 2967], '59:': [864, 941], '2217-2222Google': [865], '11Chin': [867], 'Pomerantz': [869, 882], 'DePinho': [871, 895, 973, 982], 'Trends': [873], 'Biochem.': [874], '23:': [877], '291-296Google': [878], '12Chin': [880], 'Polsky': [884], 'Jacobson': [886], 'Cohen': [888], 'Cordon-Cardo': [890, 969], 'Horner': [892], 'II,': [893], 'J.W.': [894], 'Genes': [897, 2971], 'Dev.': [898, 987, 2972, 4491, 4521], '11:': [900], '2822-2834Google': [901], '13Okuda': [903], 'Shurtleff': [905], 'S.A.': [906], 'Valentine': [907], 'M.B.': [908], 'Raimondi': [909], 'S.C.': [910], 'Head': [911], 'D.R.': [912], 'Behm': [913], 'Curcio-Brint': [915], 'A.M.': [916, 1378, 1772, 4499], 'Liu': [917], 'Q.': [918], 'Pui': [919], 'C.H.': [920], 'Blood.': [923], '85:': [925, 977], '2321-2330Google': [926], '14Munro': [928], 'F.J.': [931, 1551, 2934, 3015, 4326], 'Parkinson': [936], 'E.K.': [937], '2516-2521Google': [942], '15Quelle': [944], 'D.E.': [945], 'Cheng': [946], 'Ashmun': [948], '94:': [960], '669-673Google': [961], '16Serrano': [963], 'H.': [966, 997, 999, 1457, 1873, 1877, 1879, 2074, 2149, 4187, 4232, 4853, 4981, 4985, 4987, 5075, 5079, 5081], 'Chin': [967], 'Beach': [971], 'Cell.': [975, 1589, 1726, 4011, 4364, 4509, 5328], '27-37Google': [978], '17Sharpless': [980], 'N.E.': [981], 'Curr.': [984, 4488, 4518], 'Opin.': [985, 4489, 4519], 'Genet.': [986, 4490, 4520], '9:': [989, 1182], '22-30Google': [990], '18Nakamura': [992], 'Sakaki': [994], 'Hashimoto': [996], 'Nakase': [998], 'Ishida': [1000], 'Shimada': [1002], 'K.': [1003, 1534, 1703, 1883, 1887, 2948, 3029, 4166, 4309, 4991, 4995, 5085, 5089, 5305], 'Konishi': [1004], 'N.': [1005, 1575, 1579, 1712, 1716, 4350, 4354, 5314, 5318], '61:': [1009, 1495, 1571, 1790, 4270, 4346], '6335-6339Google': [1010], '19Serrano': [1012], 'Carcinogenesis.': [1014, 4479], '21:': [1016, 4481], '865-869Google': [1017, 4482], '20Serrano': [1019], '237:': [1025], '7-13Google': [1026], 'Type': [1028, 1268, 2644, 3168, 3501], '(IFNα,': [1031], '-β,': [1032], '-ω)': [1034], '1The': [1035, 1075], 'abbreviations': [1036, 1076], 'used': [1037, 1077, 2221, 3705, 5047], 'are:': [1038, 1078], 'IFN,': [1039, 1079], 'interferon;': [1040, 1080], 'muIFN,': [1041, 1081], 'murine': [1042, 1082], 'IFN;': [1043, 1046, 1083, 1086], 'huIFN,': [1044, 1084], 'IRF,': [1047, 1087], 'interferon': [1048, 1088, 2542, 4081], 'regulatory': [1049, 1089, 4082], 'factor;': [1050, 1090], 'MEF,': [1051, 1091], 'fibroblast;': [1054, 1094], 'STAT,': [1055, 1095], 'signal': [1056, 1096, 1219], 'transducer': [1057, 1097], 'activator': [1059, 1099], 'transcription;': [1061, 1101], 'IPTG,': [1062, 1102, 3902], 'isopropyl': [1063, 1103], 'β-d-thiogalactopyranoside;': [1064, 1104], 'MTT,': [1065, 1105], '3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium': [1066, 1106], 'bromide;': [1067, 1107], 'ISG,': [1068, 1108], 'IFN-stimulated': [1069, 1109, 1244], 'gene;': [1070, 1110], 'OAS1,': [1071, 1111, 4140], 'oligoadenylate': [1072, 1112, 4087], 'synthetase': [1073, 1113, 4088], '1.': [1074, 1114], 'possess': [1115], 'wide': [1117], 'variety': [1118], 'actions': [1120], 'among': [1121, 2655, 4420, 5217], 'antiviral': [1124, 1328, 1345, 1847], 'antiproliferative': [1126, 1330, 1610, 1845, 1920, 2661, 4450, 4658, 4702, 4760, 5177, 5395], 'activities': [1127], 'captured': [1129], 'attention': [1133], 'their': [1136, 1191], 'potential': [1137], 'therapeutic': [1138], 'uses': [1139], '(21Prejean': [1140], 'Colamonici': [1142], 'O.R.': [1143], '83-92Google': [1149], '22Mogensen': [1151], 'Lewerenz': [1153], 'Reboul': [1155], 'Lutfalla': [1157], 'Uzé': [1159], 'Interferon': [1162], 'Cytokine': [1163, 1177], '19:': [1166], '1069-1098Google': [1167], '23Rubinstein': [1169], 'Dinarello': [1171], 'C.A.': [1172], 'Oppenheim': [1173], 'J.J.': [1174, 1307], 'Hertzog': [1175], 'P.': [1176], 'Growth': [1178, 1511, 1756, 1806, 4286, 5358], 'Factor': [1179], 'Rev.': [1180, 1309], '175-181Google': [1183], 'Binding': [1185], 'receptors': [1192], 'results': [1193, 2016, 3094], 'kinases': [1198], 'Jak': [1201], 'family': [1202], '(Jak1': [1203], 'Tyk2),': [1205], 'responsible': [1208, 1325, 2031, 3913, 4804, 5133, 5392, 5420], 'tyrosine': [1210], 'phosphorylation': [1211], 'latent': [1213], 'cytoplasmic': [1214], 'factors': [1216], 'designated': [1217], 'transducers': [1220], 'activators': [1222, 1861], '1': [1225, 2177, 2280, 2283, 2286, 2290, 2294, 3774, 4071, 4089], '2': [1227], '(STAT1': [1228], 'STAT2).': [1230], 'Phosphorylated': [1231], 'STAT1,': [1232], 'STAT2,': [1233], 'protein': [1236, 4070, 4074, 4079], 'IRF': [1239], 'family,': [1240], 'p48/IRF9,': [1241], 'form': [1242, 2001], 'gene': [1245, 1266, 2627], '(ISG)': [1246], 'F3': [1247], 'complex,': [1248], 'translocates': [1250], 'nucleus': [1253], 'where': [1254], 'binds': [1256], 'promoter': [1258, 5131], 'regions': [1259], '(interferon-stimulated': [1260], 'elements': [1262, 1285], '(ISRE))': [1263], 'regulate': [1265, 1319], 'transcription.': [1267], 'formation': [1274], 'STAT1-STAT1': [1276], 'STAT1-STAT3': [1278], 'dimers': [1279], 'bind': [1281], 'DNA': [1284], '(IFNγ-activated': [1286], 'sequence': [1287], 'c-sis-inducible': [1289], 'element,': [1290], 'GAS': [1291], 'SIE,': [1293], 'respectively)': [1294, 3865], '(24Schindler': [1295, 1347], '253:': [1301, 1353], '7-14Google': [1302, 1354], '25Leonard': [1304], 'W.J.': [1305], "O'Shea": [1306], 'Annu.': [1308], 'Immunol.': [1310, 2362], '16:': [1312, 1539, 1708, 4205, 4314, 4871, 5310], '293-322Google': [1313], 'Scholar)': [1314, 2367, 5096], 'together': [1316], 'ISGF3': [1318], 'Although': [1334, 1834, 3424, 3583, 3799, 4874], 'integrity': [1336, 2674], 'Jak-STAT': [1339], '26Bromberg': [1356], 'J.F.': [1357], 'Horvath': [1358], 'C.M.': [1359, 2962], 'Wen': [1360], 'Z.': [1361], 'Schreiber': [1362, 1418], 'R.D.': [1363, 1419], 'Darnell': [1364], 'J.E.J.': [1365], '93:': [1374], '7673-7678Google': [1375], '27Gamero': [1377], 'Larner': [1379, 1773], 'Chem.': [1383, 1777], '276:': [1385, 1779], '13547-13553Google': [1386, 1780], 'STAT': [1388], 'does': [1390, 5162], 'appear': [1392], 'some': [1401, 1669, 2023, 4154, 5382], 'types': [1403, 2025], '(28Gil': [1404], 'M.P.': [1405], 'Bhon': [1406], "O'Guin": [1408], 'A.K.': [1409], 'Ramana': [1410], 'C.V.': [1411], 'Levine': [1412], 'B.': [1413, 4191, 4195, 4857, 4861], 'Stark': [1414], 'G.R.': [1415], 'Virgin': [1416], 'H.W.': [1417], '98:': [1428], '6680-6685Google': [1429], 'proliferation': [1435, 1653, 1965, 2352, 4224], 'more': [1441, 3428, 3600, 3921], 'complex': [1442], 'than': [1443, 3421, 3433, 3543, 3881, 3910, 4123, 5418], 'expected': [1444], '(29Yano': [1456, 4231], 'Iemura': [1458, 4233], 'Haramaki': [1460, 4235], 'Ogasawara': [1462, 4237], 'Takayama': [1464, 4239], 'Akiba': [1466, 4241], 'Kojiro': [1468, 4243], 'Hepatology.': [1470, 4245], '29:': [1472, 4247], '1708-1717Google': [1473, 4248], '30Roos': [1475, 4250], 'Leanderson': [1477, 4252], 'Ludgren': [1479, 4254], '1984;': [1483, 4258], '44:': [1484, 4259], '2358-2362Google': [1485, 4260], '31Rodríguez-Villanueva': [1487, 1782, 4262], 'McDonnell': [1489, 1784, 4264], 'T.J.': [1490, 1785, 4265], 'Int.': [1491, 1567, 1786, 4266, 4342], '110-114Google': [1496, 1791, 4271], '32Sangfelt': [1498, 1793, 4273], 'O.': [1499, 1519, 1688, 1746, 1794, 4274, 4294, 5290, 5348], 'Erickson': [1500, 1520, 1689, 1795, 4275, 4295, 5291], 'Castro': [1502, 1747, 1797, 4277, 5349], 'Heiden': [1504, 1799, 4279], 'Einhorn': [1506, 1522, 1691, 1751, 1801, 4281, 4297, 5293, 5353], 'Grandér': [1508, 1524, 1693, 1753, 1803, 4283, 4299, 5295, 5355], '&': [1512, 1757, 1807, 4287, 5359], 'Differ.': [1513, 1758, 1808, 4288, 5360], '8:': [1515, 1810, 4290], '343-352Google': [1516, 1811, 4291], '33Sangfelt': [1518, 4293], 'Oncogene.': [1526, 1537, 1695, 1706, 1738, 4301, 4312, 5297, 5308, 5340], '14:': [1528, 1697, 1740, 4303, 5299, 5342], '415-423Google': [1529, 1698, 4304, 5300], '34Matsuoka': [1531, 1700, 4306, 5302], 'Tani': [1533, 1702, 4308, 5304], 'Asano': [1535, 1704, 4310, 5306], '2075-2086Google': [1540, 1709, 4315, 5311], '35Jewell': [1542, 4317], 'A.P.': [1543, 4318], 'Worman': [1544, 4319], 'C.P.': [1545, 4320], 'Lydyard': [1546, 4321], 'P.M.': [1547, 4322], 'Yong': [1548, 4323], 'K.L.': [1549, 4324], 'Gilles': [1550, 4325], 'Goldstone': [1552, 4327], 'A.H.': [1553, 4328], 'Br.': [1554, 4329], 'Haematol.': [1556, 4331], '88:': [1558, 4333, 4511], '268-274Google': [1559, 4334], '36Milner': [1561, 4336], 'A.E.': [1562, 4337], 'Grand': [1563, 4338], 'R.J.A.': [1564, 4339], 'Gregory': [1565, 4340], 'C.D.': [1566, 4341], '348-354Google': [1572, 4347], '37Tieferbrun': [1574, 1711, 4349, 5313], 'Melamed': [1576, 1713, 4351, 5315], 'Levy': [1578, 1715, 4353, 5317], 'Resnitzky': [1580, 1717, 4355, 5319], 'Hoffmann': [1582, 1719, 4357, 5321], 'Reed': [1584, 1721, 4359, 5323], 'S.I.': [1585, 1722, 4360, 5324], 'Kimchi': [1586, 1723, 4361, 5325], 'Mol.': [1588, 1725, 4010, 4363, 5327], '7:': [1592, 1729, 4367, 5331], '3934-3944Google': [1593, 1730, 4368, 5332], 'Interestingly,': [1595, 3240, 3888, 4808], 'studies': [1597, 4754, 4907], 'dealing': [1598], 'characterization': [1601], 'signaling': [1604], 'lead': [1607], 'were': [1612, 2065, 2086, 2116, 2159, 2195, 2220, 2257, 2319, 2330, 2379, 2404, 2440, 2529, 2630, 2749, 3095, 3100, 3342, 3361, 3599, 4811, 5020, 5046, 5238], 'performed': [1613, 2420, 2441, 2750, 3101, 4038, 4908], 'oncogenes,': [1627], 'could': [1629, 1822, 3371, 3533, 3948, 3972, 4553, 4727, 4762], 'affect': [1630, 3779, 5276], 'Therefore,': [1636, 3545, 4526], 'should': [1638], 'example,': [1660, 5004, 5398], 'responsive': [1670], 'inducing': [1674], 'p21,': [1675, 3740], 'p27,': [1676, 5283], 'INK4D': [1678], 'decreasing': [1680], 'D3': [1684], 'cdc25A': [1686], '(33Sangfelt': [1687, 5289], '38Hobeika': [1732, 5334], 'Subramaniam': [1734, 5336], 'P.S.': [1735, 5337], 'Johnson': [1736, 5338], 'H.M.': [1737, 5339], '1165-1170Google': [1741, 5343], '39Erickson': [1743, 5345], 'Sangfelt': [1745, 5347], 'Heyman': [1749, 5351], '575-582Google': [1761, 5363], 'other': [1764, 3542, 3976, 5277], 'cases,': [1765], 'IFNα2': [1766, 3061, 3110], '(27Gamero': [1771], 'scenario,': [1815], 'genotype': [1817], 'particular': [1820], 'determine': [1823, 1911, 2725, 2978, 3685], 'whether': [1824, 1912, 2672, 2726, 2979, 3317, 3686, 3840, 4019, 5373], 'IFN': [1825, 2692, 3327, 3557, 4412, 4615, 4748, 4778, 4820, 4942, 5231], 'induces': [1826, 3080, 3753, 4943], 'arrest,': [1829], 'apoptosis,': [1830, 2711, 4794], 'no': [1832, 3230], 'response.': [1833], 'report': [1837, 4959], 'indicates': [1838], 'involved': [1842, 1917, 4790, 5436], 'IFNs,': [1852, 2721, 4563], 'p53,': [1863, 3085, 3581, 3703, 3755, 3784, 3911, 4937], 'ARF,': [1864, 1907, 1936, 3754, 3783, 3814, 3908, 4915], 'addressed': [1867, 5371], '(40Takaoka': [1868, 4976, 5070], 'Hayakawa': [1870, 4978, 5072], 'Yanal': [1872, 4980, 5074], 'Stolber': [1874, 4982, 5076], 'Negishi': [1876, 4984, 5078], 'Kikuchi': [1878, 4986, 5080], 'Sasaki': [1880, 4988, 5082], 'Imai': [1882, 4990, 5084], 'Shibue': [1884, 4992, 5086], 'Honda': [1886, 4994, 5088], 'Taniguchi': [1888, 4996, 5090], '2003;': [1891, 4012, 4999, 5093], '424:': [1892, 5000, 5094], '516-523Google': [1893, 5001, 5095], 'Because': [1895, 2694, 3300], 'agents': [1898], 'RAS': [1901, 3318, 3383, 3408, 3485, 4675], 'MYC': [1903], 'stabilize': [1904], 'via': [1906, 1935, 2649, 4612, 4945, 5013], 'sought': [1909, 2723], 'triggered': [1922], 'up-regulate': [1933, 2868], 'demonstrated': [1938], '(MEFs)': [1950], 'cells.': [1957, 1976, 3261, 3423, 3561, 3683, 3747, 3887, 4646, 4752, 4773], 'Yet': [1958], 'IFNα': [1959, 3297], 'significantly': [1962, 3443, 3807], 'reduced': [1963], 'rate': [1966], 'ARF-': [1968], 'p53-deficient': [1970], 'MEFs': [1971, 2064, 2085, 2115, 2755, 2797, 2817, 2852, 2859, 2904, 3148, 3206, 3308, 3341, 3388, 3404, 3455, 3525, 4575, 4672, 4953, 5019, 5169, 5222], 'cells,': [1979, 2989, 4902, 4911, 5203, 5488], 'characterized': [1984, 4737], 'without': [1989, 2486], 'signs': [1990], 'reconstitution': [1994], 'allowed': [2004, 4922], 'manner.': [2014], 'demonstrate': [2017, 4891, 4916, 5152], 'U2OS,': [2028], 'manner': [2040], 'apoptotic': [2044, 3234, 3448, 3897, 4929], 'do': [2052, 4954], 'share': [2054], 'same': [2056, 3256], 'linear': [2057], 'Lines': [2060], 'Reagents—Wild': [2062], 'prepared': [2066], '13.5-day': [2068], 'embryos': [2069, 3210], '(C57B6)': [2070], '(41Todaro': [2071, 2146], 'G.J.': [2072, 2147], 'Green': [2073, 2148], '1963;': [2078, 2153], '17:': [2079, 2154, 2958, 3039], '299-313Google': [2080, 2155], 'kindly': [2087, 2160], 'provided': [2088, 2161], 'Drs.': [2090, 2198, 5453], 'Jones': [2092, 5455], '(University': [2093, 5456], 'Massachusetts': [2095, 5458], 'Medical': [2096, 5459], 'School,': [2097], 'North': [2098], 'Worcester,': [2099], 'MA)': [2100], 'Roussel': [2103, 2965], 'Sher': [2106, 5464], '(St.': [2107, 5465], 'Jude': [2108, 5466], "Children's": [2109, 5467], 'Hospital,': [2110, 5468], 'Memphis,': [2111, 5469], 'TN),': [2112, 5470], 'respectively.': [2113, 3582, 5489], 'grown': [2117], 'complete': [2119], 'medium': [2120, 2124], "(Dulbecco's": [2121], 'modified': [2122], "Eagle's": [2123], 'supplemented': [2125], '10%': [2127], '(v/v)': [2128], 'fetal': [2129], 'bovine': [2130], 'serum,': [2131], 'nonessential': [2132], 'amino': [2133], 'acids,': [2134], 'glutamine,': [2135], '50': [2137, 2423, 2583], 'μm': [2138], '2-mercaptoethanol)': [2139], 'split': [2141], 'following': [2142, 2218, 2517, 2548, 2759], '3T3': [2144, 2762], 'protocol': [2145, 2519, 2550, 2763], 'NARF2': [2157, 2992, 2996, 3150, 3706], 'Dr.': [2163], 'Gordon': [2164], '(Imperial': [2166, 5474], 'Research': [2168, 5476], 'Fund,': [2169, 5477], 'London,': [2170], 'UK).': [2171], 'Murine': [2172], 'IFNα4': [2173], '(muIFNα4,': [2174], 'activity': [2176, 2183, 2191], '×': [2178, 2185, 2193], '106': [2179], 'units/ml),': [2180], 'huIFNα2': [2181], '(specific': [2182, 2190], '2.2': [2184], '108': [2186], 'units/mg),': [2187], 'huIFNβ': [2189, 2489, 3103, 3593], '4.7': [2192], '107)': [2194], 'gifts': [2196], 'Dirk': [2199], 'Gewert': [2200], '(QT': [2201], 'Genetics,': [2202], 'Cambridge,': [2203], 'UK),': [2204], 'Ronald': [2205], 'Bordens': [2206], '(Schering-Plough,': [2207], 'Kenilworth,': [2208], 'NJ),': [2209], 'Ed': [2211], 'Croze': [2212], '(Berlex': [2213], 'Biosciences,': [2214], 'Richmond,': [2215], 'CA).': [2216], 'antibodies': [2219], 'immunoblotting:': [2223], 'anti-p21': [2224], '(F-5': [2225], 'Santa': [2227, 2235], 'Cruz': [2228, 2236], 'Biotechnology),': [2229, 2237], 'anti-p53': [2230], '(FL-393': [2231], 'DO-1': [2233], 'anti-ARF': [2238], '(p14ARF': [2239], 'Ab-2': [2240], 'Lab': [2242, 2252], 'Vision-NeoMarkers;': [2243], 'ab80': [2245], 'Abcam),': [2247], 'anti-tubulin': [2249], '(Ab-4': [2250], 'Vision-NeoMarkers).': [2253], 'Immunoprecipitation': [2254], 'Immunoblotting—Cells': [2256], 'treated': [2258, 2393, 2483, 2991], 'indicated': [2260, 2339, 2396], 'under': [2261, 5039], '"Results"': [2262], 'lysed': [2264], 'lysis': [2266], 'buffer': [2267], '(50': [2268], 'mm': [2269, 2278, 2281, 2284, 2287, 2291, 2295, 3775], 'HEPES,': [2270], 'pH': [2271], '7.5,': [2272], 'containing': [2273], '0.5%': [2274], 'Triton': [2275], 'X-100,': [2276], '150': [2277, 2467], 'NaCl,': [2279], 'EDTA,': [2282], 'MgCl2,': [2285], 'sodium': [2288, 2292], 'fluoride,': [2289, 2297], 'orthovanadate,': [2293], 'phenylmethylsulfonyl': [2296], '10': [2298, 2302, 2598], 'μg/ml': [2299, 2303], 'leupeptin,': [2300], 'aprotinin)': [2304], '30': [2306, 2575, 2581, 2586], 'min': [2307, 2568], '4': [2309, 2434, 3075], '°C.': [2310], 'direct': [2312, 5126], 'immunoblotting,': [2313], '200': [2314], 'μg': [2315, 2498], 'lysate': [2318], 'directly': [2320, 5391], 'electrophoresed': [2321], 'into': [2322], '8%': [2323], '4–15%': [2325], 'gradient': [2326], 'gels.': [2327], 'proteins': [2329, 4571], 'transferred': [2331], 'polyvinylidene': [2333], 'difluoride': [2334], 'membranes,': [2335], 'immunoblotted': [2336], 'antibodies,': [2340], 'developed': [2342], 'using': [2343, 2371, 2452, 2505, 2533, 2617, 2751], 'enhanced': [2344], 'chemiluminescence': [2345], '(Pierce).': [2346], 'Proliferation': [2348], 'Apoptosis': [2350, 2449, 3504], 'Assays—Cell': [2351], 'assessed': [2354, 5034], 'performing': [2356], 'MTT': [2357, 2417, 2429], 'assays': [2358, 5057], '(42Mossman': [2359], 'Methods.': [2363], '1983;': [2364], '65:': [2365], '55-63Google': [2366], 'counts': [2370], 'automated': [2373], 'counter.': [2375], 'Briefly,': [2376], 'seeded': [2380], '10,000': [2382, 2487, 4049], '2,000': [2384], 'cells/well': [2385, 2403], '24-': [2387], '96-well': [2389], 'plates,': [2390], 'respectively,': [2391, 4466], 'concentrations': [2397], 'numbers': [2401], 'determined': [2405, 3188, 3548, 3839, 4018], 'trypsinization': [2407], 'counting': [2409], 'duplicate': [2411], 'wells': [2412], 'Coulter': [2415], 'Counter.': [2416], 'assay': [2418], 'adding': [2422], 'μl': [2424, 2599], '5': [2427, 2497, 2567, 3749], 'mg/ml': [2428], 'solution': [2430], 'last': [2433], 'h': [2435, 2774, 2791, 2865], 'experiment.': [2438], 'Experiments': [2439], 'three': [2444], 'times': [2445], 'similar': [2447, 4635], 'results.': [2448], 'Hoechst,': [2453], 'trypan': [2454], 'blue,': [2455], 'annexin': [2457, 3622, 3857], 'V': [2458, 3623, 3858], '(Alexis': [2459], 'Corp.,': [2460], 'Lausanne,': [2461], 'Switzerland)': [2462], 'staining,': [2463], 'scoring': [2464], 'random': [2470], 'fields.': [2471], 'Induction': [2472], 'ISGs—Total': [2474], 'RNA': [2475], 'isolated': [2477], 'units/ml': [2488, 3645, 3767, 3936, 4050], 'TRIzol': [2491], 'Reagent': [2492], '(Invitrogen).': [2493], 'A': [2494, 3862], 'total': [2495], 'each': [2500, 2601], 'sample': [2501, 2602], 'reverse': [2503, 2525, 2536, 2625, 4040], 'transcribed': [2504], 'cloned': [2507], 'avian': [2508], 'myeloblastosis': [2509], 'virus': [2510, 3988, 5026], 'first-strand': [2511], 'cDNA': [2512], 'synthesis': [2513], 'kit': [2514, 2539], 'Invitrogen': [2516], 'suggested': [2520, 2551], 'manufacturer.': [2523, 2554], 'Following': [2524], 'transcription,': [2526], 'samples': [2528, 2572], 'processed': [2530], 'PCR': [2532, 2556], 'MultiGene-12': [2535], 'transcriptase-PCR': [2537, 2626, 4041], 'profiling': [2538], '(SuperArray,': [2545], 'Frederick,': [2546], 'MD)': [2547], 'program': [2557], 'consisted': [2558], 'initial': [2561, 5125], 'incubation': [2562], '94': [2564, 2578], '°C': [2565, 2579, 2584, 2590], 'denature': [2570], 'followed': [2573], 'cycles': [2576], 's,': [2582, 2587], '72': [2589], '45': [2592], 's.': [2593], 'After': [2594], 'completion': [2595], 'PCR,': [2597], 'separated': [2604], 'agarose': [2606], 'gel': [2607], 'electrophoresis': [2608], 'stained': [2610], 'scanned': [2612], 'digital': [2615], 'image': [2616], 'CCD': [2619], 'camera.': [2620], 'levels': [2622, 2788, 2812, 2922, 3071, 3118, 3803, 3878, 3952, 4027], 'profile': [2629], 'quantified': [2631], 'NIH': [2633], 'Image': [2634], '(version': [2635], '1.62).': [2636], 'Normalized': [2637], 'values': [2638], 'represented': [2640], '-fold': [2642], 'increases.': [2643], 'Induce': [2647], 'MEFs—The': [2652], 'ample': [2653, 4404], 'variability': [2654, 3369, 4405, 4431], 'cancer': [2656], 'raises': [2667], 'question': [2669, 5368], 'commonly': [2682, 2741, 4437, 4458], 'altered': [2683], 'during': [2684], 'process,': [2687], 'influences': [2688], 'outcome': [2690], 'treatment.': [2693, 4821], 'insults': [2704], 'leads': [2705], 'attributes': [2715], 'activated': [2730, 4459], 'surveillance': [2733], 'To': [2735, 2977, 3333, 3684, 3719, 4033, 4545, 4731], 'avoid': [2736, 3367, 4577], 'presence': [2738, 3610, 3851, 3890, 4579, 4800, 4919], 'observed': [2742, 3096, 3237, 3373, 3663, 3679, 3787, 5017], 'tumor-derived': [2744], 'lines,': [2746, 3675], 'experiments': [2748, 3099], 'primary': [2754, 5221], 'maintained': [2756], 'culture': [2758, 5041, 5063], 'typical': [2761], '(Fig.': [2764, 2818, 2836, 2873, 3124, 3135, 3219, 3238, 3395, 3463, 3595, 3647, 3792, 3860, 3930], '1A).': [2765], 'Fig.': [2766, 3057, 3241, 3397, 3748, 4055], '1B': [2767], 'shows': [2768, 3059, 3243, 3399, 3750, 4057], '24': [2773, 4053], '(lane': [2775, 2792, 3091, 3762], '3)': [2776], 'muIFNα4': [2778, 2862, 2876, 3218, 3253, 3411, 3425, 3440], 'treatment': [2779, 3216, 3438, 3594, 3642, 3790, 3868, 3933, 4384, 4413, 5106, 5232], '(1,000': [2780, 3412], 'units/ml)': [2781, 3413], 'still': [2784, 2806], 'expressed': [2785], 'high': [2787], '48': [2790, 2864], '4)': [2793], 'early': [2795, 5136], '(P2,': [2798], '2).': [2800, 2821, 3092, 3763], 'detected': [2807, 2927, 3966], 'above': [2808, 3069], 'elevated': [2810, 3808], 'base-line': [2811, 3070], 'present': [2813, 3955], 'late': [2815], '1C,': [2819, 2837], 'lane': [2820, 3126], 'As': [2822, 4091], 'expected,': [2823], 'increase': [2825, 2833, 3064, 3116, 3232, 3444, 4060, 4893, 5400], 'accompanied': [2829], 'concomitant': [2832], 'lanes': [2838, 3794], '3': [2839, 3639, 3795, 3874], '5).': [2841], 'requirement': [2843, 3510], 'confirmed': [2854, 3390], 'finding': [2856], 'stimulated': [2860], 'did': [2866, 3113, 3441, 3777, 3893, 4654, 4676, 5097, 5223], '1D).': [2874], 'P53–/–MEFs': [2880], 'indicating': [2881, 4960], 'require': [2886, 5164], 'It': [2893, 5120, 5248, 5267], 'p53–/–': [2903], 'pronounced': [2908], 'MEFs,': [2913, 4602], 'has': [2916, 4836, 5268], 'been': [2917, 4630, 5269], 'reported': [2918, 3980, 5007, 5270], 'previously': [2919, 5021], 'higher': [2921, 3877, 3946, 4026], 'normally': [2926], 'lack': [2931, 3247, 3508, 3578], '(43Stott': [2933, 3014], 'Bates': [2935, 3016], 'James': [2937, 3018], 'M.C.': [2938, 3019, 4168], 'McConnell': [2939, 3020], 'B.B.': [2940, 3021], 'Starborg': [2941, 3022], 'Brookes': [2943, 3024], 'Palmero': [2945, 3026], 'Ryan': [2947, 3028], 'Hara': [2949, 3030], 'EMBO': [2955, 3036, 4202, 4868], '5001-5014Google': [2959, 3040], '44Eischen': [2961], 'Weber': [2963, 4516], 'J.D.': [2964, 4517], 'M.F.': [2966], 'Cleveland': [2969], 'J.L.': [2970], '13:': [2974], '2658-2669Google': [2975], 'huIFNα.2.': [2995], 'correspond': [2998], 'ARF–/–P53+/+': [3000], 'isopropyl-β-d-thiogalactopyranoside': [3012], '(IPTG)': [3013], '45Llanos': [3042], 'Rowe': [3046], 'Nat.': [3050, 4500], '3:': [3054, 4504], '445-452Google': [3055], '2A': [3058], 'fails': [3062], 'amount': [3066], 'NARF': [3073, 3847, 3982, 4623, 4910, 5487], '(lanes': [3074], '5),': [3077], 'whereas': [3078, 5032, 5141, 5240], 'IPTG': [3079, 3112, 3752, 3776, 3789, 3870, 3960], 'amounts': [3082], 'p14ARF,': [3084], 'its': [3087, 3737], 'downstream': [3088, 3738], 'target,': [3089, 3739], 'p21': [3090, 3757, 3786, 3818], 'Identical': [3093], 'when': [3097, 3374, 5018], '(data': [3104], 'shown).': [3106], 'combination': [3108], 'further': [3115], '2A,': [3125], '3).': [3127], 'able': [3131], '2B)': [3136], '(ARF+/+P53–/–).': [3143], 'obtained': [3146, 4764, 4951], 'indicate': [3152], 'ARF.': [3162, 3853, 4613, 5148], 'Growth-inhibitory': [3164], 'Effect': [3165], 'Promoted': [3166], 'Is': [3171], 'Not': [3172, 3497], 'Altered': [3173], 'Lack': [3176], 'Transformation': [3183], 'Oncogenic': [3185], 'RASV12—We': [3186], 'next': [3187, 3315, 3547, 3838], 'Wild': [3204], 'derived': [3207], 'independent': [3209, 3701], 'inhibition': [3214], '3A).': [3220], 'corresponded': [3224], 'effect,': [3228, 4703], '3E).': [3239, 3464], '3B': [3242], 'efficiency': [3257], 'suggests': [3264], 'there': [3267, 4093, 4402, 4706, 5206], 'redundant': [3269, 4708], 'pathways': [3270], 'compensate': [3272, 4712], 'component': [3291, 3471], 'MEFs.': [3299, 3332, 3544, 4665], 'RASV12': [3302, 3352, 3458], 'transform': [3304], 'tested': [3316], 'affected': [3320, 3482], 'address': [3334, 4732, 5099], 'question,': [3336], 'infected': [3343], 'empty': [3346, 3716], 'pBabe-hygromycin': [3347], 'vector': [3348, 3350, 3461, 3717], 'encoding': [3351], 'selected': [3353], 'hygromycin': [3355], 'B,': [3356, 3864], 'surviving': [3359], 'kept': [3362], 'pool': [3365], 'individual': [3375], 'clones': [3376], 'isolated.': [3378], 'Western': [3392, 3968], 'blot': [3393], 'analysis': [3394], '3C).': [3396], '3D': [3398], 'transformed': [3405], 'just': [3414], 'better': [3420], 'control': [3422, 3744, 3759, 4062], 'slightly': [3427], 'retrovirus-transduced': [3431], 'controls,': [3437], 'number': [3446], 'expressing': [3456, 3709, 3984], 'compared': [3459, 4816], 'controls': [3462], 'mutation': [3489], '(but': [3496, 3631, 4784, 5196], 'p53)': [3498, 5198], 'Contributes': [3499], 'IFN-induced': [3503, 3694], 'Human': [3506], 'Cells—The': [3507], 'raised': [3526, 4687], 'possibility': [3528, 4797], 'first': [3563, 4565], '(ARF–/–P53+/+)': [3571], '(ARF+/+P53–/–)': [3574], 'they': [3577], 'showed': [3588, 3866, 3992], 'good': [3590], '4),': [3596], 'sensitive,': [3601], 'few': [3605], 'days': [3606, 3640, 3875], 'culture,': [3608], 'floating': [3612], 'dead': [3613], 'evident.': [3616], 'study': [3618], 'staining': [3624, 3859], 'confirms': [3625], 'almost': [3627, 3820], '50%': [3628], 'U2OS)': [3633], 'death': [3637, 3845, 5227], '1,000': [3644, 3766], '4C).': [3648], 'although': [3653], 'osteosarcoma': [3673, 5172, 5246], 'ARF+/+': [3681, 4781], 'plays': [3688, 4970], 'through': [3696, 4226], 'stably': [3708], '(NARF-DNp53)': [3714], '(NARF-Puro).': [3718], 'confirm': [3720], 'DNp53,': [3729], 'NARF-DNp53': [3746, 3801, 3918], 'NARF-Puro': [3760, 3886], 'Treatment': [3764], 'alone': [3769, 3791, 3884, 3938], 'association': [3772], '5,': [3793], '4,': [3797], 'respectively).': [3798], 'completely': [3821], 'obliterated,': [3822], 'demonstrating': [3823], 'DNp53': [3825, 3892], 'effectively': [3826], 'function': [3829], 'endogenous': [3832, 4627], 'protein.': [3836], 'would': [3842], 'Trypan': [3854], 'blue': [3855], '6,': [3861], 'drug': [3883], 'inhibit': [3895], 'plus': [3901, 3940], 'suggesting': [3903], 'rather': [3909, 5417], 'effect.': [3916, 4807, 5396], 'consistently': [3920], 'sensitive': [3922], '6B,': [3931], 'compare': [3932], '100': [3935], 'IPTG).': [3941], 'reason': [3943], 'sensitivity': [3947, 3994], 'low': [3951], '(leaky': [3961], 'promoter),': [3962], 'cannot': [3964], 'blotting.': [3969], 'Alternatively,': [3970, 4720], 'factors,': [3977], 'recently': [3979], 'papilloma': [3987, 5025], 'E6': [3989, 5027], 'protein,': [3990, 5140], 'increased': [3993], 'ARF-mediated': [3996], 'necrosis': [4002], 'factor': [4003, 4083], '(46Rocha': [4004], 'Campbell': [4006], 'K.J.': [4007], 'Perkins': [4008], 'N.D.': [4009], '12:': [4013], '15-25Google': [4014], 'Finally,': [4016], 'correlated': [4024], 'ISGs.': [4032], 'achieve': [4034], 'goal,': [4036], 'semiquantitative': [4039], 'stimulation': [4043], 'h.': [4054], '7': [4056, 4084], 'fold': [4059, 4099, 4111], 'over': [4061], 'level': [4065, 5403], 'guanylate-binding': [4069], '(GBP1),': [4072], 'interferon-induced': [4073], '35': [4075], '(IFI35),': [4076], 'interferon-inducible': [4077], '56-kDa': [4078], 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