Publication Information

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4062, 4075, 4199, 4247, 4258, 4291, 4342, 4373, 4394, 4404], 'adamalysin': [12, 258, 509, 2512], 'family': [13, 259, 983, 1854, 2514], 'transmembrane': [15, 25, 226, 261, 271, 472, 649, 778, 802, 972, 995, 1141, 1157, 1260, 1330, 1535, 1817, 2025, 2081, 2195, 2516, 2571], 'metalloproteases': [16, 262, 2517], 'that': [17, 33, 76, 142, 263, 279, 322, 388, 554, 1504, 1648, 2073, 2817, 2827, 3070, 3252, 3333, 3363, 3386, 3781, 4019], 'effects': [18, 264], 'ectodomain': [19, 265, 557, 658, 775, 958, 1011, 1292, 1326, 1340, 1402, 1531, 1650, 1799, 1811, 1848, 1972, 2021, 2199, 2794], 'cleavage': [20, 266, 547, 659, 776, 2075], 'and': [21, 122, 133, 152, 236, 267, 368, 379, 398, 482, 657, 670, 783, 795, 969, 981, 1139, 1270, 1276, 1307, 1645, 1804, 1815, 1863, 2068, 2078, 2208, 2279, 2358, 2518, 2530, 2562, 2573, 2698, 2798, 3030, 3377, 3428, 3443, 3462, 3594, 3633, 3681, 3817, 3840, 3871, 3911, 3950, 3967, 3997, 4005, 4056, 4061, 4068, 4084, 4110, 4196, 4285, 4296, 4349, 4410], 'release': [22, 268, 619, 785, 1287, 2268], 'many': [24, 270], 'proteins,': [26, 272, 996, 2351], 'including': [27, 273, 3480], 'transforming': [28, 227, 274, 473, 503, 977], 'growth': [29, 87, 131, 143, 172, 181, 215, 222, 228, 275, 333, 377, 389, 418, 427, 461, 468, 474, 504, 525, 529, 532, 973, 978, 986, 1004, 1145, 1264, 1331, 1802, 1858, 1860, 3334, 3393, 3408, 3440], 'factor-α.': [30, 276], 'Growth': [31, 277, 1087], 'factors': [32, 278, 974, 987, 1005, 1146, 1265, 1803], 'act': [34, 280, 2822], 'through': [35, 46, 115, 281, 292, 361, 1819, 1868, 2185, 3258, 3345], 'tyrosine': [36, 282, 1158, 1806], 'kinase': [37, 54, 65, 201, 283, 300, 311, 447, 508, 536, 1522, 1792, 1807, 1825, 1958, 2016, 2803, 3166, 3262, 3351], 'receptors,': [38, 284, 1150, 2354], 'as': [39, 41, 167, 285, 287, 413, 976, 994, 1002, 1006, 1526, 1639, 2272, 2274, 2521, 2688, 2823, 3411, 3413, 3640, 3655, 3657, 4027, 4137, 4328, 4330], 'well': [40, 286, 2273, 3412, 3656, 4329], 'other': [42, 288, 1816, 2080, 2350, 2543, 2851, 3249], 'stimuli,': [43, 289], 'induce': [44, 290, 1282, 1298, 1810, 3077], 'shedding': [45, 67, 224, 291, 313, 470, 558, 755, 964, 1012, 1293, 1327, 1403, 1532, 1651, 1812, 1849, 1973, 2022, 2200, 2347, 2745, 2795, 2808, 2829, 3074, 3213, 3257], 'activation': [47, 196, 293, 442, 672, 1346, 1797, 1869, 1953, 2536, 3346], 'Erk': [50, 199, 296, 445, 1823, 1872, 2012, 3260, 3349], 'mitogen-activated': [51, 297, 501, 1789], 'protein': [52, 61, 298, 307, 502, 654, 1521, 1790, 1833, 2547, 2814, 3015, 3165, 3628, 4350], '(MAP)': [53, 299, 1791], 'pathway': [55, 301, 1827, 1874, 3264], 'without': [56, 302, 1828, 2809, 4246], 'need': [58, 304, 1830, 2811], 'new': [60, 306, 1832, 2813], 'synthesis.': [62, 308], 'How': [63, 309], 'MAP': [64, 200, 310, 446, 534, 1824, 1957, 2015, 2802, 3261, 3350], 'regulates': [66, 312, 966, 2828], 'by': [68, 230, 314, 476, 666, 801, 2085, 2559, 2564, 2796, 2830, 3164, 3214, 3767, 3784, 3851, 3942, 4040, 4289, 4357, 4369], 'TACE': [69, 81, 147, 210, 241, 315, 327, 393, 456, 487, 2197, 2264, 2341, 2550, 2754, 2797, 2835, 2978, 3034, 3078, 3157, 3344, 3362, 3376, 3380, 3387, 3621, 3675, 3690, 3764, 3773, 3827, 3842, 4026, 4109, 4131, 4156, 4180, 4218, 4340], 'not': [71, 153, 189, 219, 317, 399, 435, 465, 630, 2202], 'known.': [72, 318], 'We': [73, 90, 319, 336, 3330, 3354, 3384, 3398], 'now': [74, 320, 3331], 'report': [75, 321], 'cytoplasmic': [78, 103, 211, 238, 324, 349, 457, 484, 2575, 2819, 2845, 3028, 3160, 3373, 3676], 'domain': [79, 104, 212, 325, 350, 458, 2556, 2572, 2576, 2737, 2820, 2833, 2846, 3029, 3374, 3677, 3688], 'phosphorylated': [83, 127, 329, 373, 3163, 3389], 'in': [84, 128, 178, 330, 374, 424, 556, 761, 1795, 2027, 2198, 2210, 2262, 2346, 2364, 2694, 2732, 2836, 3063, 3158, 3405, 3631, 3637, 3776, 3813, 3845, 3973, 3990, 4049, 4086, 4096, 4112, 4157, 4165, 4173, 4305, 4341, 4403], 'response': [85, 129, 179, 331, 375, 425, 2028, 2837, 3406], 'to': [86, 99, 125, 130, 180, 213, 243, 332, 345, 371, 376, 426, 459, 489, 771, 791, 793, 1281, 1297, 1317, 1339, 1400, 1507, 1971, 2029, 2728, 2741, 2806, 2838, 3020, 3031, 3207, 3340, 3369, 3379, 3407, 3434, 3627, 3679, 3806, 4185, 4273], 'factor': [88, 132, 182, 334, 378, 428, 526, 530, 533, 1861, 3335, 3394, 3409, 3441], 'stimulation.': [89, 137, 183, 335, 383, 429, 3397, 3421], 'also': [91, 337, 638, 965, 999, 1336, 1866, 1969, 2206, 2343, 2519, 3355], 'identified': [92, 165, 338, 411, 3356, 3399], 'naturally': [94, 340], 'expressed': [95, 341, 989], 'smaller': [96, 342], 'polypeptide': [97, 343, 622], 'corresponding': [98, 344], 'most': [100, 346, 1278, 3370], 'TACE.': [106, 231, 352, 477], 'This': [107, 353, 2971], 'protein,': [108, 354, 2357], 'which': [109, 355, 797, 1519, 3152, 3416, 3800], 'we': [110, 356, 3364], 'named': [111, 357], 'SPRACT,': [112, 358, 4397], 'derived': [114, 360], 'alternative': [116, 362, 3358], 'translation': [117, 363, 3359], 'TACE-coding': [120, 366], 'sequence': [121, 367, 2548, 2972, 3154, 3829], 'is,': [123, 369], 'similarly': [124, 370, 3378], 'TACE,': [126, 372, 2507, 2848, 3481], 'phorbol': [134, 380, 495, 1516], '12-myristate': [135, 381, 496], '13-acetate': [136, 382, 497], 'Phosphoamino': [138, 384], 'acid': [139, 385, 2844, 3822], 'analysis': [140, 386], 'revealed': [141, 387, 2072], 'factor-induced': [144, 173, 216, 223, 390, 419, 462, 469], 'phosphorylation': [145, 185, 217, 239, 391, 431, 463, 485, 3079, 3204, 3342, 3404, 3419, 3426, 4154], 'occurs': [148, 394], 'only': [149, 395, 631, 1266, 2203, 2751], 'on': [150, 154, 195, 396, 400, 441, 1273, 1304, 1325, 2532, 3390, 3867, 4294, 4359], 'serine': [151, 397], 'threonine': [155, 401], 'or': [156, 206, 402, 452, 643, 1155, 1262, 1852, 1966, 2973, 3336, 3395, 3819, 4107, 4167, 4170, 4209, 4238, 4245], 'tyrosine.': [157, 403], 'Tryptic': [158, 404], 'mapping': [159, 405], 'experiments': [160, 406, 2070, 4392], 'coupled': [161, 407], 'with': [162, 408, 541, 882, 1509, 2980, 3022, 3156, 3642, 3981, 3993, 4090, 4101, 4133, 4178, 4193, 4198, 4202, 4244, 4298, 4345, 4372], 'site-directed': [163, 409], 'mutagenesis': [164, 410], 'Ser819': [166, 412], 'major': [169, 415, 3401], 'target': [170, 416], 'phosphorylation,': [174, 420, 4219], 'whereas': [175, 421, 3248], 'Ser791undergoes': [176, 422], 'dephosphorylation': [177, 191, 423, 437], 'The': [184, 232, 430, 478, 617, 2546, 2685, 2791, 3422, 3458, 3610, 3649, 3757, 3791, 3835, 3962, 4015, 4276, 4412], 'Ser819,': [187, 433], 'but': [188, 434, 637, 2205], 'Ser791,': [193, 439], 'depends': [194, 440], 'pathway.': [202, 448, 3353], 'Increased': [203, 449], 'SPRACT': [204, 235, 450, 481, 3367, 3432], 'expression': [205, 451, 2265, 3758, 3808, 3847, 4022, 4102, 4181], 'mutation': [207, 453], 'inactivate': [214, 460], 'did': [218, 464], 'detectably': [220, 466], 'affect': [221, 467], 'roles': [233, 479, 970, 1787], 'remain': [242, 488, 3433], 'be': [244, 490, 799, 1000, 1337, 2742, 3435, 3874], 'defined.': [245, 491], 'tumor': [492, 779], 'TNF-α': [498, 788, 803, 878, 1864, 2204], 'extracellular': [506, 550, 2554, 3687], 'signal-regulated': [507], 'Chinese': [510], 'hamster': [511], 'ovary': [512], "Dulbecco's": [513, 3974], 'modified': [514, 3465, 3975], 'minimal': [515, 3976], 'essential': [516, 3977], 'medium': [517, 3978, 4088, 4114], 'dialyzed': [518, 4230], 'fetal': [519, 3450, 3983, 3999, 4053, 4231], 'bovine': [520, 3451, 3984, 4000, 4054, 4232], 'serum': [521, 3396, 3452, 4055, 4187, 4233], 'polyvinylidene': [522], 'difluoride': [523], 'epidermal': [524], 'heparin': [527, 1856], 'binding-EGF-like': [528], 'fibroblast': [531, 3439], 'kinase/Erk': [535], 'Various': [537], 'cell': [538, 625, 992, 1296, 2086, 3965, 3969, 4017, 4070, 4343, 4407], 'surface': [539, 993, 2087], 'proteins': [540, 1536, 1818, 2026, 2082, 4132], 'diverse': [542, 2024, 2365], 'functions': [543], 'undergo': [544], 'regulated': [545, 3382], 'proteolytic': [546], 'their': [549, 1010, 1333], 'domains,': [551], 'process': [553], 'results': [555], '(for': [559], 'review': [560], 'see': [561], 'Refs.': [562], '1Ehlers': [563], 'M.R.': [564], 'Riordan': [565], 'J.F.': [566], 'Biochemistry.': [567], '1991;': [568, 1020, 1415, 1430], '30:': [569], '10065-10074Crossref': [570], 'PubMed': [571, 587, 600, 612, 685, 699, 723, 749, 812, 945, 1023, 1036, 1051, 1077, 1093, 1131, 1168, 1194, 1222, 1254, 1357, 1377, 1391, 1418, 1436, 1458, 1473, 1493, 1556, 1583, 1630, 1666, 1690, 1718, 1756, 1781, 1844, 1884, 1908, 1946, 1983, 2003, 2041, 2061, 2112, 2135, 2163, 2254, 2314, 2335, 2410, 2443, 2467, 2502, 2621, 2680, 2718, 2786, 2907, 2966, 3005, 3053, 3124, 3145, 3195, 3243, 3287, 3325, 3515, 3543, 3567, 3730, 3752, 3906, 3937, 4125, 4149], 'Scopus': [572, 588, 613, 686, 700, 724, 750, 813, 946, 1024, 1037, 1052, 1078, 1094, 1132, 1169, 1195, 1223, 1255, 1358, 1378, 1392, 1419, 1459, 1474, 1494, 1557, 1584, 1631, 1691, 1719, 1757, 1909, 1947, 2004, 2062, 2113, 2136, 2164, 2255, 2315, 2336, 2411, 2444, 2468, 2503, 2622, 2681, 2719, 2787, 2908, 2967, 3006, 3054, 3125, 3146, 3196, 3244, 3288, 3326, 3516, 3544, 3568, 3731, 3753, 3907], '(256)': [573], 'Google': [574, 590, 601, 615, 688, 702, 726, 752, 815, 870, 948, 1026, 1039, 1054, 1080, 1096, 1134, 1171, 1197, 1225, 1237, 1257, 1360, 1380, 1394, 1421, 1437, 1461, 1476, 1496, 1559, 1586, 1633, 1667, 1693, 1721, 1759, 1782, 1845, 1885, 1911, 1949, 1984, 2006, 2042, 2064, 2115, 2138, 2166, 2181, 2257, 2317, 2338, 2413, 2446, 2470, 2505, 2624, 2683, 2721, 2789, 2910, 2969, 3008, 3056, 3127, 3148, 3198, 3246, 3290, 3328, 3518, 3546, 3570, 3733, 3755, 3909, 3938, 4126, 4150], 'Scholar,': [575, 591, 602, 689, 703, 727, 816, 1027, 1040, 1055, 1081, 1097, 1172, 1198, 1226, 1238, 1361, 1381, 1422, 1438, 1462, 1477, 1587, 1668, 1694, 1722, 1760, 1886, 1912, 1985, 2043, 2116, 2139, 2167, 2318, 2447, 2471, 2625, 2911, 3128, 3291, 3519, 3734], '2Hooper': [576], 'N.M.': [577], 'Karran': [578], 'E.H.': [579], 'Turner': [580], 'A.J.': [581], 'Biochem.': [582, 1017, 1047, 1467, 1488, 2713, 3000, 3562], 'J.': [583, 744, 856, 860, 863, 891, 907, 1016, 1042, 1066, 1120, 1208, 1210, 1243, 1351, 1366, 1407, 1426, 1427, 1440, 1466, 1489, 1538, 1561, 1571, 1572, 1662, 1679, 1707, 1745, 1776, 1840, 1880, 1897, 1935, 1979, 1992, 2037, 2050, 2090, 2100, 2101, 2129, 2145, 2152, 2176, 2303, 2432, 2456, 2659, 2708, 2714, 2775, 2945, 2997, 3001, 3039, 3042, 3191, 3239, 3276, 3314, 3493, 3503, 3504, 3525, 3532, 3557, 3563, 3712, 3719, 3736, 3741, 4121, 4145], '1997;': [584, 1354, 2178, 2618, 2677, 2904, 2963, 3121], '321:': [585], '265-279Crossref': [586], '(562)': [589], '3Werb': [592], 'Z.': [593, 1240, 1670, 1888, 3267], 'Yan': [594], 'Y.': [595, 913, 921, 1734, 1738, 1742, 1924, 1928, 1932, 3037, 3169, 3181, 3217, 3229, 3303, 3307, 3311, 3716], 'Science.': [596, 681, 1626, 2250, 2406, 3902], '1998;': [597, 1069, 1450, 1548, 1627, 2251, 2407, 3192, 3240, 3929], '282:': [598, 1628, 2252, 2408], '1279-1280Crossref': [599], '4Blobel': [603], 'C.P.': [604, 2173, 2712, 2999, 3041, 3561, 3718, 3740], 'Curr.': [605, 3927], 'Opin.': [606], 'Cell': [607, 1352], 'Biol.': [608, 695, 1067, 1121, 1233, 1244, 1353, 1367, 1428, 1573, 1680, 1708, 1746, 1898, 1936, 1993, 2051, 2102, 2153, 2304, 2433, 2457, 2776, 3043, 3140, 3277, 3315, 3505, 3533, 3720, 3742, 3928], '2000;': [609, 1090, 1369, 1710, 2332, 2435, 2459, 2494, 2715, 2778, 3564], '12:': [610], '606-612Crossref': [611], '(225)': [614], 'Scholar).': [616, 753, 871, 949, 1135, 1258, 1395, 1497, 1634, 1846, 1950, 2007, 2065, 2182, 2258, 2339, 2506, 2684, 2722, 2790, 2970, 3009, 3057, 3149, 3199, 3329, 3547, 3571, 3756, 4127, 4151], 'subsequent': [618], 'from': [623, 3447, 3456, 3469, 3485, 3554, 3587, 3598, 3612, 3645, 3663, 3694, 4074, 4347, 4388], 'can': [626, 769, 998, 1147, 1335, 3076], 'have': [627, 1784, 2071], 'profound': [628], 'consequences': [629], 'at': [632, 639, 990, 2701, 3856, 4162, 4362], 'cellular': [634, 765], 'physiological': [635, 1653, 1967, 2366, 2987], 'level': [636], 'more': [641], 'tissue-wide': [642], 'even': [644], 'systemic': [645], 'level.': [646], 'For': [647, 1513], 'example,': [648, 1514], 'L-selectin': [650, 661, 2207], 'an': [652, 758, 2553, 2689, 2747, 3072, 3357, 3476, 3810, 4265, 4281, 4385], 'adhesion': [653], 'for': [655, 1309, 1831, 2193, 2541, 2744, 2812, 3618, 3652, 3760, 3880, 4104, 4212, 4280, 4365, 4382], 'leukocytes,': [656], 'may': [662, 2537, 2821, 3254], 'therefore': [663, 2538], 'down-regulate': [664, 3033], 'inflammation': [665], 'limiting': [667], 'neutrophil': [668], 'accumulation': [669], 'lymphocyte': [671], '(5Kishimoto': [673], 'T.K.': [674, 1448, 1546, 1567, 2096, 2151, 3499, 3531], 'Jutila': [675, 1445, 1543], 'M.A.': [676, 834, 1446, 1544, 2653, 2939, 3924], 'Berg': [677], 'E.L.': [678], 'Butcher': [679], 'E.C.': [680, 691], '1989;': [682, 1188, 1216], '245:': [683], '1238-1241Crossref': [684], '(922)': [687], '6Butcher': [690], 'Adv.': [692, 1030, 1162], 'Exp.': [693, 865, 2130], 'Med.': [694, 719, 2131], '1992;': [696, 1033, 1165], '323:': [697], '181-194Crossref': [698], '(64)': [701], '7Strausbaugh': [704], 'H.J.': [705], 'Green': [706], 'P.G.': [707], 'Lo': [708], 'E.': [709, 899, 1085, 1483, 1744, 1772, 1934, 2324, 3130, 3189, 3237, 3313, 3922], 'Tangemann': [710], 'K.': [711, 840, 1704, 2143, 3179, 3227, 3488, 3523, 3896], 'Reichling': [712], 'D.B.': [713], 'Rosen': [714], 'S.D.': [715], 'Levine': [716], 'J.D.': [717, 862, 1766, 2451, 2675, 2710, 2961, 3559, 3708], 'Nat.': [718], '1999;': [720, 937, 1470, 1663, 1682, 1841, 1881, 1900, 1980, 1995, 2038, 2053, 3002, 3279, 3722, 4122, 4146], '5:': [721, 2495], '1057-1061Crossref': [722], '(46)': [725], '8Gerli': [728], 'R.': [729, 927, 1029, 1083, 1161, 1174, 1186, 1660, 1838, 1878, 1977, 2035, 2419, 2606, 2762, 2892, 3109, 3175, 3223, 3706, 4119, 4143], 'Gresele': [730], 'P.': [731, 842, 1565, 1593, 1696, 1706, 2094, 2217, 2373, 2415, 2487, 2594, 2655, 2758, 2880, 2941, 3097, 3497, 3714], 'Bistoni': [732], 'O.': [733, 2481], 'Paolucci': [734], 'C.': [735, 741, 1770, 2124, 2141, 2449, 2473, 2479, 3521], 'Lanfrancone': [736], 'L.': [737, 903, 1481, 1563, 2092, 2322, 3136, 3495, 3702, 3738], 'Fiorucci': [738], 'S.': [739, 1413, 1569, 1700, 1732, 1922, 2098, 2596, 2882, 3099, 3187, 3235, 3301, 3501, 3894], 'Muscat': [740], 'Costantini': [742], 'V.': [743, 826], 'Immunol.': [745, 2177], '2001;': [746, 867, 1246, 1748, 1778, 1938, 3317, 3744], '166:': [747], '832-840Crossref': [748], '(21)': [751], 'Because': [754], 'plays': [756, 3059], 'such': [757, 975], 'important': [759], 'role': [760, 2192, 2363, 2731, 3062, 3430], 'regulation': [763, 2792], 'functions,': [766], 'its': [767, 952, 982, 1853, 2362, 2695, 3159], 'dysregulation': [768], 'contribute': [770, 792], 'disease': [772], 'conditions.': [773, 1654], 'Thus,': [774, 1259, 1801, 2008], '(TNF-α)1': [782], 'consequent': [784], 'soluble': [787, 1003, 1138, 1289, 2270], 'thought': [790, 1506, 2727], 'cachexia': [794], 'arthritis,': [796], 'cannot': [798], 'induced': [800, 4217], '(9Beutler': [804], 'B.': [805, 822, 838, 1212, 1442, 1540, 2147, 3527], 'Cerami': [806], 'A.': [807, 1014, 1044, 1405, 1414, 1424, 1464, 1485, 1487, 1991, 2049, 2326, 2328, 2485, 2491, 3134, 3138, 3185, 3233], 'Nature.': [808, 2617, 2676, 2903, 2962, 3120], '1986;': [809], '320:': [810], '584-588Crossref': [811], '(1310)': [814], '10Conway': [817], 'J.G.': [818], 'Andrews': [819], 'R.C.': [820, 832, 2175], 'Beaudet': [821], 'Bickett': [823, 2632, 2918], 'D.M.': [824, 909, 2633, 2919], 'Boncek': [825], 'Brodie': [827], 'T.A.': [828, 2649, 2935], 'Clark': [829], 'R.L.': [830], 'Crumrine': [831], 'Leenitzer': [833], 'McDougald': [835], 'D.L.': [836, 935], 'Han': [837], 'Hedeen': [839], 'Lin': [841], 'Milla': [843, 2630, 2916], 'M.': [844, 846, 897, 901, 911, 917, 1057, 1103, 1178, 1184, 1348, 1678, 1698, 1726, 1736, 1740, 1896, 1916, 1926, 1930, 2286, 2604, 2661, 2890, 2947, 3107, 3171, 3219, 3275, 3295, 3305, 3309], 'Moss': [845], 'Pink': [847], 'H.': [848, 1658, 1836, 1876, 1975, 2033, 3173, 3221, 3710, 3953, 4117, 4141], 'Rabinowitz': [849], 'M.H.': [850, 2651, 2937, 3926], 'Tippin': [851], 'T.': [852, 905, 1182, 1724, 1728, 1914, 1918, 2671, 2957, 3177, 3183, 3225, 3231, 3293, 3297, 3487], 'Scates': [853], 'P.W.': [854], 'Selph': [855], 'Stimpson': [857], 'S.A.': [858, 3920], 'Warner': [859], 'Becherer': [861, 2674, 2709, 2960, 3558, 3707], 'Pharmacol.': [864], 'Ther.': [866], '298:': [868], '900-908PubMed': [869], 'In': [872, 1285, 1315, 1635, 1951, 3200, 4390], 'addition,': [873, 1952], 'families': [874], 'carrying': [875], 'non-cleavable': [877], 'receptor': [879, 1154, 1283, 1345, 2750], 'are': [880, 960, 988, 1277, 1398, 1500, 1505], 'presented': [881], 'severe': [883], 'autoimmune': [884], 'reactions': [885], '(11McDermott': [886], 'M.F.': [887, 1615, 2239, 2395, 2588, 2874, 3091], 'Aksentijevich': [888], 'I.': [889, 923], 'Galon': [890], 'McDermott': [892], 'E.M.': [893], 'Ogunkolade': [894], 'B.W.': [895], 'Centola': [896], 'Mansfield': [898], 'Gadina': [900], 'Karenko': [902], 'Pettersson': [904], 'McCarthy': [906], 'Frucht': [908], 'Aringer': [910], 'Torosyan': [912], 'Teppo': [914], 'A.M.': [915], 'Wilson': [916], 'Karaarslan': [918], 'H.M.': [919], 'Wan': [920], 'Todd': [922], 'Wood': [924], 'G.': [925, 1065, 1350, 1365, 1385, 1674, 1892, 2455, 2657, 2663, 2943, 2949, 3271, 3945], 'Schlimgen': [926], 'Kumarajeewa': [928], 'T.R.': [929], 'Cooper': [930], 'S.M.': [931], 'Vella': [932], 'J.P.': [933], 'Kastner': [934], 'Cell.': [936, 1187, 1215, 1449, 1547, 2330, 2493, 3141], '97:': [938], '133-144Abstract': [939], 'Full': [940, 942, 1072, 1074, 1126, 1128, 1191, 1219, 1249, 1251, 1372, 1374, 1433, 1453, 1455, 1551, 1553, 1578, 1580, 1685, 1687, 1713, 1715, 1751, 1753, 1903, 1905, 1941, 1943, 1998, 2000, 2056, 2058, 2107, 2109, 2158, 2160, 2309, 2311, 2438, 2440, 2462, 2464, 2497, 2499, 2781, 2783, 3048, 3050, 3282, 3284, 3320, 3322, 3510, 3512, 3538, 3540, 3725, 3727, 3747, 3749, 3932, 3934], 'Text': [941, 943, 1073, 1075, 1127, 1129, 1192, 1220, 1250, 1252, 1373, 1375, 1434, 1454, 1456, 1552, 1554, 1579, 1581, 1686, 1688, 1714, 1716, 1752, 1754, 1904, 1906, 1942, 1944, 1999, 2001, 2057, 2059, 2108, 2110, 2159, 2161, 2310, 2312, 2439, 2441, 2463, 2465, 2498, 2500, 2782, 2784, 3049, 3051, 3283, 3285, 3321, 3323, 3511, 3513, 3539, 3541, 3726, 3728, 3748, 3750, 3933, 3935], 'PDF': [944, 1076, 1130, 1193, 1221, 1253, 1376, 1435, 1457, 1555, 1582, 1689, 1717, 1755, 1907, 1945, 2002, 2060, 2111, 2162, 2313, 2442, 2466, 2501, 2785, 3052, 3286, 3324, 3514, 3542, 3729, 3751, 3936], '(1119)': [947], 'However,': [950], 'despite': [951], 'importance,': [953], 'molecular': [955], 'mechanisms': [956, 2534], 'underlying': [957], 'processes': [959], 'poorly': [961], 'understood.': [962], 'Ectodomain': [963], 'activities': [968], '(TGF-α)': [980], 'members.': [984], 'These': [985, 1498], 'yet': [997, 1640], 'released': [1001], 'result': [1008, 1962, 4029], '(12Pandiella': [1013], 'Massagué': [1015, 1209, 1406, 1425, 1570, 2099, 3502], 'Soc.': [1018, 1468], 'Trans.': [1019, 1469], '19:': [1021], '259-262Crossref': [1022], '(11)': [1025], '13Derynck': [1028], 'Cancer': [1031, 1163, 1232], 'Res.': [1032, 1164, 1387], '58:': [1034, 1166], '27-52Crossref': [1035, 1167], '(250)': [1038, 1170], '14Massagué': [1041], 'Pandiella': [1043, 1486, 2327, 3137], 'Annu.': [1045], 'Rev.': [1046, 1089], '1993;': [1048], '62:': [1049], '515-541Crossref': [1050], '(600)': [1053], '15Vecchi': [1056], 'Rudolph-Owen': [1058], 'L.A.': [1059], 'Brown': [1060], 'C.L.': [1061, 1101, 2284], 'Dempsey': [1062], 'P.J.': [1063], 'Carpenter': [1064, 1349, 1364, 1384], 'Chem.': [1068, 1122, 1245, 1368, 1429, 1574, 1681, 1709, 1747, 1899, 1937, 1994, 2052, 2103, 2154, 2305, 2434, 2458, 2777, 3044, 3278, 3316, 3506, 3534, 3721, 3743], '273:': [1070], '20589-20595Abstract': [1071], '(82)': [1079], '16Iwamoto': [1082], 'Mekada': [1084, 1743, 1933, 3188, 3236, 3312], 'Cytokine': [1086], 'Factor': [1088], '11:': [1091], '335-344Crossref': [1092], '(186)': [1095], '17Sunnarborg': [1098], 'S.W.': [1099, 1597, 2221, 2282, 2377], 'Hinkle': [1100, 2283], 'Stevenson': [1102, 2285], 'Russell': [1104, 1600, 2224, 2287, 2380], 'W.E.': [1105, 1601, 2225, 2288, 2381], 'Raska': [1106, 2289], 'C.S.': [1107, 2290], 'Peschon': [1108, 2291, 2428, 2452, 2583, 2771, 2869, 3086], 'J.J.': [1109, 1589, 2213, 2292, 2369, 2429, 2453, 2584, 2772, 2870, 3087], 'Castner': [1110, 1602, 2226, 2293, 2382, 2589, 2875, 3092], 'B.J.': [1111, 1603, 2227, 2294, 2383, 2590, 2876, 3093], 'Gerhart': [1112, 2295, 2603, 2889, 3106], 'M.J.': [1113, 2296, 3918], 'Paxton': [1114, 1620, 2244, 2297, 2400, 2611, 2897, 3114], 'R.J.': [1115, 1621, 2245, 2298, 2401, 2612, 2898, 3115], 'Black': [1116, 1624, 2125, 2248, 2299, 2404, 2430, 2488, 2773, 3787, 4043], 'R.A.': [1117, 1625, 2126, 2249, 2300, 2405, 2425, 2431, 2489, 2578, 2768, 2774, 2864, 3081], 'Lee': [1118, 1213, 1229, 1598, 2222, 2301, 2378], 'D.C.': [1119, 1214, 1230, 1599, 2223, 2302, 2379], '2002;': [1123, 1388, 1490, 2306, 3045, 3142], '277:': [1124, 2307, 3046], '12838-12845Abstract': [1125, 2308], '(369)': [1133, 2316], 'Both': [1136], 'forms': [1142], 'these': [1144, 1318, 3425], 'activate': [1148, 1401, 1649, 2807, 3255], 'i.e.': [1151], 'EGF/TGF-α': [1153], 'related': [1156, 1263], 'kinases': [1159], '(13Derynck': [1160], '18Brachmann': [1173], 'Lindquist': [1175], 'P.B.': [1176], 'Nagashima': [1177], 'Kohr': [1179], 'W.': [1180, 1363, 1383, 2635, 2665, 2921, 2951], 'Lipari': [1181], 'Napier': [1183], 'Derynck': [1185, 1659, 1837, 1877, 1976, 2034, 4118, 4142], '56:': [1189, 1217], '691-700Abstract': [1190], '(340)': [1196], '19Wong': [1199], 'S.T.': [1200], 'Winchell': [1201], 'L.F.': [1202], 'McCune': [1203], 'B.K.': [1204], 'Earp': [1205], 'H.S.': [1206], 'Teixido': [1207], 'Herman': [1211], '495-506Abstract': [1218], '(375)': [1224], '20Luetteke': [1227], 'N.C.': [1228], 'Semin.': [1231], '1990;': [1234], '1:': [1235], '265-275PubMed': [1236], '21Aguilar': [1239], 'Slamon': [1241], 'D.J.': [1242], '276:': [1247, 1749, 1939, 3318, 3745], '44099-44107Abstract': [1248], '(26)': [1256], 'TGF-α': [1261, 1814, 1851, 2077, 2209, 2271], 'exert': [1267], 'autocrine': [1268], 'activity': [1269], 'stimulate': [1271], 'receptors': [1272, 1334, 1808], 'adjacent': [1274], 'cells': [1275, 1306, 2260, 3987, 4007, 4046, 4161, 4172, 4277], 'likely': [1279], 'unable': [1280], 'internalization.': [1284], 'contrast,': [1286, 1636], 'ligand': [1290, 1322, 2860], 'following': [1291], 'allows': [1294, 1308], 'biological': [1299], 'effects,': [1300], 'e.g.': [1301], 'TGF-α-mediated': [1302], 'proliferation,': [1303], 'non-adjacent': [1305], 'ligand-induced': [1310, 1344], 'internalization': [1311], 'receptors.': [1314], 'addition': [1316], 'two': [1319], 'modes': [1320], 'signaling': [1323, 1511, 1646, 1793, 1826, 1873, 2017, 2804, 3263, 3352], 'depending': [1324], 'factor,': [1332], 'subject': [1338], 'cleavage,': [1341], 'thereby': [1342], 'down-regulating': [1343], '(22Vecchi': [1347], '139:': [1355], '995-1003Crossref': [1356], '(114)': [1359], '23Zhou': [1362], '275:': [1370, 1711, 2436, 2460, 2779], '34737-34743Abstract': [1371], '(86)': [1379], '24Zhou': [1382], 'Inflamm.': [1386], '51:': [1389], '91-101Crossref': [1390], '(15)': [1393], 'Diverse': [1396], 'stimuli': [1397, 2031], 'known': [1399, 1525, 1641, 2520], '(25Pandiella': [1404], 'Proc.': [1408], 'Natl.': [1409], 'Acad.': [1410], 'Sci.': [1411], 'U.': [1412], '88:': [1416], '1726-1730Crossref': [1417], '(181)': [1420], '26Pandiella': [1423], '266:': [1431], '5769-5773Abstract': [1432], '27Kahn': [1439], 'Walcheck': [1441, 1539, 2146, 3526], 'Migaki': [1443, 1541], 'G.I.': [1444, 1542], 'Kishimoto': [1447, 1545, 1566, 2095, 2150, 3489, 3498, 3530], '92:': [1451, 1549], '809-818Abstract': [1452, 1550], '(177)': [1460, 1558], '28Merlos-Suarez': [1463], 'Arribas': [1465], '27:': [1471], '243-246Crossref': [1472], '(17)': [1475], '29Montero': [1478], 'J.C.': [1479, 2320, 3132], 'Yuste': [1480, 2321, 3135], 'Diaz-Rodriguez': [1482, 2323], 'Esparis-Ogando': [1484, 2325, 3133], '363:': [1491], '211-221Crossref': [1492], '(50)': [1495], 'inducers': [1499, 1644], 'often': [1501, 1960], 'artificial': [1502, 3073], 'compounds': [1503], 'correlate': [1508], 'natural': [1510, 1643], 'pathways.': [1512], 'ester': [1517], 'PMA,': [1518, 3071], 'activates': [1520], 'C,': [1523], 'potent': [1528], 'activator': [1529], 'various': [1534, 2030, 2079, 2349], '(27Kahn': [1537], 'Scholar,30Arribas': [1560], 'Coodly': [1562, 2091, 3494], 'Vollmer': [1564, 2093, 3496], 'Rose-John': [1568, 2097, 3500], '1996;': [1575, 2104, 2155, 3507, 3535], '271:': [1576, 2105, 2156, 3508, 3536], '11376-11382Abstract': [1577, 2106, 3509], '(361)': [1585, 2114, 3517], '31Peschon': [1588], 'Slack': [1590, 2214, 2370, 2416, 2585, 2759, 2871, 3088], 'J.L.': [1591, 1672, 1890, 2215, 2371, 2417, 2586, 2673, 2760, 2872, 2959, 3089, 3269], 'Reddy': [1592, 2216, 2372, 2593, 2879, 3096], 'Stocking': [1594, 2218, 2374, 2591, 2877, 3094], 'K.L.': [1595, 2219, 2375, 2592, 2878, 3095], 'Sunnarborg': [1596, 2220, 2376], 'Johnson': [1604, 2228, 2384, 2609, 2895, 3112], 'R.S.': [1605, 2229, 2385, 2610, 2896, 3113], 'Fitzner': [1606, 2230, 2386, 2607, 2893, 3110], 'J.N.': [1607, 2231, 2387, 2608, 2894, 3111], 'Boyce': [1608, 2232, 2388], 'R.W.': [1609, 2233, 2389], 'Nelson': [1610, 2234, 2390, 2597, 2883, 3100], 'N.': [1611, 1702, 2235, 2391, 2477, 2598, 2600, 2884, 2886, 3101, 3103], 'Kozlosky': [1612, 2236, 2392, 2422, 2581, 2765, 2867, 3084], 'C.J.': [1613, 1623, 2237, 2247, 2393, 2403, 2423, 2582, 2614, 2766, 2868, 2900, 3085, 3117], 'Wolfson': [1614, 2238, 2394, 2587, 2873, 3090], 'Rauch': [1616, 2240, 2396, 2579, 2865, 3082], 'C.T.': [1617, 2241, 2397, 2580, 2866, 3083], 'Cerretti': [1618, 2242, 2398, 2420, 2615, 2763, 2901, 3118], 'D.P.': [1619, 2243, 2399, 2421, 2616, 2764, 2902, 3119], 'March': [1622, 2246, 2402, 2613, 2899, 3116], '1281-1284Crossref': [1629, 2253, 2409], '(1371)': [1632, 2256, 2412], 'little': [1637], 'about': [1642], 'pathways': [1647, 1794, 2018, 2805], 'under': [1652], 'Recent': [1655], 'studies': [1656, 2067, 2531], '(32Fan': [1657, 1835, 1875, 1974, 2032, 4116, 4140], 'EMBO': [1661, 1839, 1879, 1978, 2036, 3190, 3238, 4120, 4144], '18:': [1664, 1842, 1882, 1981, 2039, 4123, 4147], '6962-6972Crossref': [1665, 1843, 1883, 1982, 2040, 4124, 4148], '33Gechtman': [1669, 1887], 'Alonso': [1671, 1889, 3268], 'Raab': [1673, 1891, 3270], 'Ingber': [1675, 1893, 3272], 'D.E.': [1676, 1894, 3273], 'Klagsbrun': [1677, 1895, 3274], '274:': [1683, 1901, 1996, 2054, 3280, 3723], '28828-28835Abstract': [1684, 1902, 3281], '(160)': [1692, 1910, 3289], '34Gutwein': [1695], 'Oleszewski': [1697], 'Mechtersheimer': [1699], 'Agmon-Levin': [1701], 'Krauss': [1703], 'Altevogt': [1705], '15490-15497Abstract': [1712], '(157)': [1720], '35Umata': [1723, 1913, 3292], 'Hirata': [1725, 1915, 3170, 3218, 3294], 'Takahashi': [1727, 1733, 1917, 1923, 3296, 3302], 'Ryu': [1729, 1919, 3298], 'F.': [1730, 1920, 2475, 2669, 2955, 3299], 'Shida': [1731, 1921, 3300], 'Tsuneoka': [1735, 1925, 3304], 'Miura': [1737, 1927, 3306], 'Masuda': [1739, 1929, 3308], 'Horiguchi': [1741, 1931, 3310], '30475-30482Abstract': [1750, 1940, 3319], '(87)': [1758, 1948, 3327], '36Xu': [1761], 'K.P.': [1762], 'Zoukhri': [1763], 'D.': [1764, 2427, 2645, 2770, 2931], 'Zieske': [1765], 'Dartt': [1767], 'D.A.': [1768], 'Sergheraert': [1769], 'Loing': [1771], 'Yu': [1773], 'F.S.': [1774], 'Am.': [1775], 'Physiol.': [1777], '281:': [1779], 'C603-C614Crossref': [1780], 'Scholar)': [1783, 3910, 3939], 'uncovered': [1785], 'shedding.': [1800], 'activated': [1805, 3882, 3913], 'rapidly': [1809], 'induction': [1820, 3210], 'synthesis': [1834, 2815], 'PMA-induced': [1847], 'binding-epidermal': [1857], 'factor-like': [1859], '(HB-EGF)': [1862], 'mediated': [1867, 2084], 'p38': [1956, 2014], 'pathway,': [1959], 'inflammatory': [1964], 'mediators': [1965], 'stress,': [1968], 'leads': [1970, 3339], '37Rizoli': [1986, 2044], 'S.B.': [1987, 2045], 'Rotstein': [1988, 2046], 'O.D.': [1989, 2047], 'Kapus': [1990, 2048], '22072-22080Abstract': [1997, 2055], '(105)': [2005, 2063], 'inhibition': [2009], 'both': [2011, 3605], 'and/or': [2013], 'strongly': [2019], 'suppresses': [2020], 'Inhibitor': [2066], 'functional': [2069, 2263], 'metalloprotease(s)': [2088], '(30Arribas': [2089, 3492], '38Crowe': [2117], 'P.D.': [2118], 'Walter': [2119], 'B.N.': [2120], 'Mohler': [2121], 'K.M.': [2122], 'Otten-Evans': [2123], 'Ware': [2127], 'C.F.': [2128], '1995;': [2132], '181:': [2133], '1205-1210Crossref': [2134], '(245)': [2137], '39Feehan': [2140, 3520], 'Darlak': [2142, 3522], 'Kahn': [2144, 3524], 'Spatola': [2148, 3528], 'A.F.': [2149, 3529], '7019-7024Abstract': [2157, 3537], '(132)': [2165, 3545], '40Solomon': [2168], 'K.A.': [2169, 2602, 2888, 3105], 'Covington': [2170], 'M.B.': [2171], 'DeCicco': [2172], 'Newton': [2174], '159:': [2179], '4524-4531PubMed': [2180], 'Functional': [2183], 'inactivation': [2184], 'gene': [2186, 3812, 4032], 'targeting': [2187], 'has': [2188, 2342, 2738, 2854, 3017, 3067], 'subsequently': [2189], 'implicated': [2190, 2345], 'protease': [2196, 2693, 2832, 4332], 'vivo': [2211], '(31Peschon': [2212, 2368], 'Accordingly,': [2259], 'deficient': [2261, 2983], 'display': [2266], 'impaired': [2267], 'TGF-α-related': [2276], 'amphiregulin,': [2277], 'HB-EGF,': [2278], 'neuregulins': [2280], '(17Sunnarborg': [2281], '41Montero': [2319], 'Mol.': [2329, 2492, 3139], 'Neurosci.': [2331], '16:': [2333], '631-648Crossref': [2334], '(150)': [2337], 'Finally,': [2340], 'been': [2344, 2739, 3018, 3068], 'e.g.ErbB4,': [2352], 'TNF': [2353], 'β-amyloid': [2355], 'precursor': [2356], 'Notch,': [2359], 'thus': [2360], 'illustrating': [2361], 'contexts': [2367], 'Scholar,42Reddy': [2414], 'Davis': [2418, 2605, 2761, 2891, 3108], 'Blanton': [2424, 2767], 'Shows': [2426, 2769], '14608-14614Abstract': [2437, 2780], '(443)': [2445, 2788], '43Rio': [2448], 'Buxbaum': [2450], 'Corfas': [2454], '10379-10387Abstract': [2461], '(267)': [2469], '44Brou': [2472], 'Logeat': [2474], 'Gupta': [2476], 'Bessia': [2478], 'LeBail': [2480], 'Doedens': [2482], 'J.R.': [2483, 2643, 2929], 'Cumano': [2484], 'Roux': [2486], 'Israel': [2490], '207-216Abstract': [2496], '(899)': [2504], '(ADAM)': [2513], 'ADAM': [2522, 2852], '17,': [2523], '"sheddase."': [2527], 'Its': [2528], 'characterization': [2529], 'provide': [2539], 'models': [2540], 'how': [2542], 'adamalysins': [2544], 'function.': [2545], 'consists': [2551], 'metalloprotease': [2555], 'flanked': [2557], 'upstream': [2558], 'prodomain': [2561, 2686], 'downstream': [2563], 'cysteine-rich': [2566], 'disintegrin': [2567, 2736], 'domain,': [2568, 3161], 'single': [2570, 3818], '(45Black': [2577, 2863, 3080], 'Srinivasan': [2595, 2881, 3098], 'Boiani': [2599, 2885, 3102], 'Schooley': [2601, 2887, 3104], '385:': [2619, 2678, 2905, 2964, 3122], '729-733Crossref': [2620, 2906, 3123], '(2728)': [2623, 2909, 3126], '46Moss': [2626, 2912], 'M.L.': [2627, 2913], 'Jin': [2628, 2914], 'S.L.': [2629, 2915], 'M.E.': [2631, 2917], 'Burkhart': [2634, 2920], 'Carter': [2636, 2922], 'H.L.': [2637, 2923], 'Chen': [2638, 2924], 'W.J.': [2639, 2925], 'Clay': [2640, 2926], 'W.C.': [2641, 2927], 'Didsbury': [2642, 2928], 'Hassler': [2644, 2930], 'Hoffman': [2646, 2932], 'C.R.': [2647, 2933], 'Kost': [2648, 2934], 'Lambert': [2650, 2936], 'Leesnitzer': [2652, 2938], 'McCauley': [2654, 2940], 'McGeehan': [2656, 2942], 'Mitchell': [2658, 2944], 'Moyer': [2660, 2946], 'Pahel': [2662, 2948], 'Rocque': [2664, 2950], 'Overton': [2666, 2952], 'L.K.': [2667, 2953], 'Schoenen': [2668, 2954], 'Seaton': [2670, 2956], 'Su': [2672, 2958], '733-736Crossref': [2679, 2965], '(1490)': [2682, 2968], 'serves': [2687], 'inhibitor': [2690, 3460, 3477, 4249, 4333], 'zymogen': [2696], 'state': [2697], 'removed': [2700], 'late': [2703], 'Golgi': [2704], 'processing': [2705], 'stage': [2706], '(47Schlondorff': [2707, 3556], 'Blobel': [2711, 2998, 3040, 3560, 3696, 3717, 3739], '347:': [2716, 3565], '131-138Crossref': [2717, 3566], '(315)': [2720, 3569], 'Although': [2723], 'it': [2724], 'was': [2725, 3205, 3454, 3482, 3552, 3615, 3661, 3765, 3782, 3794, 4008, 4037, 4135, 4255, 4263, 4271, 4287, 4354, 4401], 'originally': [2726], 'play': [2729], 'substrate': [2733], 'recognition,': [2734], 'shown': [2740, 3019, 3206], 'required': [2743], 'interleukin': [2748], '1': [2749, 4316, 4319], 'among': [2752], 'several': [2753, 2850], 'substrates': [2755], 'tested': [2756], '(42Reddy': [2757], 'ability': [2800], 'suggest': [2816], 'signal': [2825], 'transducer': [2826], 'intracellular': [2839, 3064], 'activities.': [2840], 'Interestingly,': [2841, 3150], '130-amino': [2843], 'like': [2849], 'members,': [2853], 'potential': [2856], 'Src': [2857], 'homology': [2858], '3': [2859], 'protein-binding': [2861], 'motif': [2862], 'proximal': [2975], 'region': [2976], 'interacts': [2979], 'mitotic': [2981], 'arrest': [2982], '2,': [2984], 'although': [2985], 'relevance': [2988], 'this': [2990, 3203, 3582], 'interaction': [2991], 'unknown': [2993], '(48Nelson': [2994], 'K.K.': [2995], 'Schlondorff': [2996, 3038, 3711], '343:': [3003], '673-680Crossref': [3004], '(76)': [3007], 'More': [3010], 'recently,': [3011], 'PDZ': [3013], 'domain-containing': [3014], 'PTPH1': [3016], 'interact': [3021], 'carboxyl': [3024], 'terminus': [3025], 'possibly': [3032], 'function': [3035, 3423], '(49Zheng': [3036], '42463-42470Abstract': [3047], '(100)': [3055], 'Phosphorylation': [3058], 'critical': [3061], 'signaling.': [3065], 'It': [3066], 'reported': [3069], 'activator,': [3075], '50Diaz-Rodriguez': [3129], 'Montero': [3131], '13:': [3143], '2031-2044Crossref': [3144], '(259)': [3147], 'MDC9,': [3151], 'shares': [3153], 'similarity': [3155], 'Cδ': [3167], '(51Izumi': [3168, 3216], 'Hasuwa': [3172, 3220], 'Iwamoto': [3174, 3222], 'Umata': [3176, 3224], 'Miyado': [3178, 3226], 'Tamai': [3180, 3228], 'Kurisaki': [3182, 3230], 'Sehara-Fujisawa': [3184, 3232], 'Ohno': [3186, 3234], '17:': [3193, 3241], '7260-7272Crossref': [3194, 3242], '(475)': [3197, 3245], 'one': [3201], 'study': [3202], 'regulate': [3208], 'HB-EGF': [3212, 3256], 'PMA': [3215, 3253, 3337, 4239], 'Scholar),': [3247], 'findings': [3250], 'indicate': [3251], 'instead': [3265], '(33Gechtman': [3266], 'show': [3332, 3385], 'stimulation': [3338], 'enhanced': [3341], 'product': [3360], 'name': [3365], 'SPRACT.': [3366], 'corresponds': [3368], 'undergoes': [3381], 'phosphorylation.': [3383], 'serines': [3391], 'upon': [3392, 3420, 3876], 'site': [3402], 'stimulation,': [3410], 'another': [3414, 3549], 'serine,': [3415], 'shows': [3417], 'decreased': [3418], 'sites': [3427], 'characterized.': [3436], 'Recombinant': [3437], 'acidic': [3438], '(FGF)': [3442], 'EGF': [3444, 4225], 'were': [3445, 3467, 3576, 3691, 3830, 3849, 3940, 3971, 3988, 4047, 4057, 4072, 4099, 4183, 4278, 4303, 4380], 'purchased': [3446, 3455, 3468, 3553, 3662], 'Calbiochem.': [3448], 'Dialyzed': [3449], '(FBS)': [3453, 4234], 'Invitrogen.': [3457], 'MEK1': [3459, 3883], 'U0126': [3461, 4250], 'sequencing': [3463, 3854], 'grade': [3464], 'trypsin': [3466], 'Promega': [3470], '(San': [3471, 3591], 'Luis': [3472], 'Obispo,': [3473], 'CA).': [3474], 'TAPI-1,': [3475], 'metalloproteases,': [3479], 'gift': [3484], 'Dr.': [3486, 3695, 3785, 3943, 3951, 4041], '(Boehringer': [3490], 'Ingelheim)': [3491], 'Phenanthroline,': [3548], 'metalloprotease/TACE': [3550], 'inhibitor,': [3551], 'Sigma': [3555], 'Four': [3572], 'polyclonal': [3573, 3669, 3683], 'anti-TACE': [3574, 4386], 'antibodies': [3575, 4346], 'used': [3577, 4381], 'throughout': [3578], 'course': [3580], 'study.': [3583], 'A': [3584, 3667], 'rabbit': [3585, 3659, 3668, 4348], 'antiserum': [3586, 3597, 3684], 'QED': [3588, 3613], 'Bioscience,': [3589], 'Inc.': [3590], 'Diego,': [3592], 'CA),': [3593], 'goat': [3596], 'Santa': [3599, 3646, 3664], 'Cruz': [3600, 3647, 3665], 'Biotechnology': [3601], '(Santa': [3602], 'Cruz,': [3603], 'CA)': [3604], 'recognize': [3606], 'carboxyl-terminal': [3608], 'sequence.': [3609], 'antibody': [3611, 3644, 3670, 4387], 'Bioscience': [3614], 'found': [3616], 'preferable': [3617], 'analyzing': [3619, 4393], 'endogenous': [3620], 'because': [3622], 'higher': [3625], 'affinity': [3626], 'A-agarose': [3629], 'beads': [3630, 4353, 4379], 'immunoprecipitation': [3632, 4383], 'cleaner': [3635], 'background': [3636], 'Western': [3638], 'blotting': [3639], 'compared': [3641], 'Biotechnology.': [3648, 3666], 'blocking': [3650], 'peptide': [3651], 'antisera': [3654], 'normal': [3658], 'IgG': [3660], 'raised': [3671], 'against': [3672, 3685], 'recombinant': [3674], 'fused': [3678], 'glutathioneS-transferase,': [3680], 'generous': [3692], 'gifts': [3693], '(Sloan-Kettering': [3697], 'Institute,': [3698], 'New': [3699], 'York)': [3700], '(52Lum': [3701], 'Wong': [3703], 'B.R.': [3704], 'Josien': [3705], 'Erdjument-Bromage': [3709], 'Tempst': [3713], 'Choi': [3715], '13613-13618Abstract': [3724], '(366)': [3732], '53Schlondorff': [3735], 'Lum': [3737], '14665-14674Abstract': [3746], '(115)': [3754], 'vector': [3759, 3780, 4182], 'wild': [3762, 3838, 4105], 'type': [3763, 3839, 4106], 'constructed': [3766, 3831], 'PCR': [3768], 'amplification': [3769], 'human': [3772, 3803], 'cDNA': [3774, 3793], 'cloned': [3775], 'bacteriophage': [3778], 'λ': [3779], 'provided': [3783, 3875, 3941, 4039], 'Roy': [3786, 4042], '(Immunex,': [3788], 'Seattle,': [3789], 'WA).': [3790], 'PCR-amplified': [3792], 'inserted': [3795, 3811], 'into': [3796, 4257], 'pRK5': [3798], 'vector,': [3799], 'uses': [3801], 'cytomegalovirus': [3804], 'promoter': [3805], 'drive': [3807], 'mammalian': [3814], 'cells.': [3815], 'Deletion': [3816], 'multiple': [3820], 'amino': [3821], 'substitution': [3823], 'mutants': [3824], 'coding': [3828, 3843], 'using': [3832, 4010, 4059, 4384], 'PCR-based': [3833], 'approaches.': [3834], 'sequences': [3836, 3844], 'mutant': [3841], 'all': [3846], 'plasmids': [3848, 3879], 'confirmed': [3850], 'automated': [3852], 'DNA': [3853], 'performed': [3855, 4136], 'University': [3858, 4076], 'California,': [3860], 'San': [3861, 4079], 'Francisco,': [3862], 'Biomolecular': [3863], 'Resource': [3864], 'Center.': [3865], 'Information': [3866], 'plasmid': [3869], 'design': [3870], 'construction': [3872], 'will': [3873], 'request.': [3877], 'Expression': [3878], 'constitutively': [3881, 3912], '(ΔN-S218E-S222D)': [3884], '(54Mansour': [3885], 'S.J.': [3886], 'Matten': [3887], 'W.T.': [3888], 'Hermann': [3889], 'A.S.': [3890], 'Candia': [3891], 'J.M.': [3892], 'Rong': [3893], 'Fukasawa': [3895], 'Vande': [3897], 'Woude': [3898], 'G.F.': [3899], 'Ahn': [3900, 3946], 'N.G.': [3901], '1994;': [3903], '265:': [3904], '966-970Crossref': [3905], '(1263)': [3908], 'Erk2': [3914], '(MCMV5-Erk2-MEK1': [3915], 'LA)': [3916], '(55Robinson': [3917], 'Stippec': [3919], 'Goldsmith': [3921], 'White': [3923], 'Cobb': [3925, 3954], '8:': [3930], '1141-1150Abstract': [3931], 'Nathalie': [3944], '(University': [3947, 3955], 'Colorado)': [3949], 'Melanie': [3952], 'Texas': [3957], 'Southwestern': [3958], 'Medical': [3959], 'Center),': [3960], 'respectively.': [3961], 'HeLa': [3963, 4159], 'S3': [3964, 4160], 'line': [3966, 3970, 4018], 'HEK293': [3968, 4006], 'maintained': [3972, 4048], '(DMEM)': [3979], 'supplemented': [3980, 3992, 4201], '7%': [3982], 'serum.': [3985, 4001], 'CHO': [3986, 4004, 4093, 4171], 'cultured': [3989, 4085, 4111, 4197, 4279], 'DMEM': [3991, 4050, 4200, 4270], '2': [3994, 4213, 4312, 4366], 'mm': [3995, 4313, 4317, 4323, 4326], 'proline': [3996], '10%': [3998, 4052, 4091, 4203], 'Transfection': [4002], 'achieved': [4009], 'LipofectAMINE': [4012, 4060], 'reagent': [4013, 4064], '(Invitrogen).': [4014, 4065], 'EC2': [4016, 4045], 'lacks': [4020], 'catalytically': [4024], 'active': [4025], 'targeted': [4031], 'inactivation,i.e.': [4033], 'taceΔZn/ΔZn': [4035], 'mutation,': [4036], 'kindly': [4038], '(Immunex).': [4044], 'containing': [4051, 4308], 'transfected': [4058, 4100, 4177], 'Plus': [4063], 'K562,': [4066], 'THP-1,': [4067], 'U937': [4069], 'lines': [4071], 'obtained': [4073], 'California': [4078], 'Francisco': [4080], 'Tissue': [4081], 'Culture': [4082], 'Facility': [4083], 'RPMI': [4087], 'supplement': [4089], 'FBS.': [4092], 'cells,': [4094], 'grown': [4095], '6-well': [4097, 4174], 'plates,': [4098], 'vectors': [4103], 'mutated': [4108], 'serum-free': [4113], 'overnight': [4115, 4186], 'Metabolic': [4128], 'labeling': [4129, 4259, 4286], '[35S]cysteine/methionine': [4134], 'described': [4138], 'previously': [4139], 'To': [4152, 4215], 'detect': [4153], 'vivo,': [4158], '90%': [4163], 'confluency': [4164], '6-': [4166], '10-cm': [4168], 'dishes': [4169], 'plates': [4175, 4293], 'transiently': [4176], 'subjected': [4184], 'starvation': [4188], 'before': [4189], '32P': [4190], 'labeling,': [4191], 'washed': [4192], 'phosphate-free': [4194, 4269], 'DMEM,': [4195], '(v/v)': [4204], '[32P]orthophosphate': [4205], '(PerkinElmer': [4206], 'Life': [4207], 'Sciences': [4208], 'Amersham': [4210], 'Biosciences)': [4211], 'h.': [4214], 'observe': [4216], 'FGF': [4220], '(final': [4221, 4226, 4235, 4240, 4251], 'concentration,': [4222, 4227, 4236, 4241, 4252], '10': [4223, 4228, 4253, 4325, 4398], 'ng/ml),': [4224, 4229], '20%)': [4237], '20': [4242], 'nm),': [4243], 'MEK': [4248], 'μm),': [4254], 'added': [4256, 4272], 'medium.': [4260], 'When': [4261], 'FBS': [4262], 'used,': [4264], 'equal': [4266], 'volume': [4267], 'control': [4274], 'wells.': [4275], 'additional': [4282], '15': [4283], 'min,': [4284], 'terminated': [4288], 'placing': [4290], 'culture': [4292], 'ice': [4295], 'washing': [4297], 'ice-cold': [4299], 'phosphate-buffered': [4300, 4306], 'saline.': [4301], 'Cells': [4302], 'lysed': [4304], 'saline': [4307], '1%': [4309], 'Nonidet': [4310], 'P-40,': [4311], 'sodium': [4314], 'orthovanadate,': [4315], 'NaF,': [4318], 'μm4-(2-aminoethyl)benzenesulfonyl': [4320], 'fluoride,': [4321], '5': [4322], 'EDTA,': [4324], 'phenanthroline': [4327], '"Complete"': [4331], 'mixture': [4334], '(Roche': [4335], 'Applied': [4336], 'Science).': [4337], 'Immunoprecipitation': [4338], 'extract': [4344], 'A-conjugated': [4351], 'agarose': [4352], 'carried': [4355], 'out': [4356], 'rotating': [4358], 'platform': [4361], '4': [4363], '°C': [4364], 'h,': [4367], 'followed': [4368], 'three': [4370], 'washes': [4371], 'above': [4374], 'lysis': [4375], 'buffer.': [4376], 'Protein': [4377], 'G': [4378], 'goat.': [4389], 'selected': [4391], 'nature': [4395], 'μm': [4399], 'TAPI-1': [4400], 'included': [4402], 'steps': [4405], 'lysate': [4408], 'preparation': [4409], 'immunoprecipitation.': [4411], 'immunopreci': [4413]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2044157798', 'counts_by_year': [{'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 11}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 8}], 'updated_date': '2024-12-15T05:49:13.024164', 'created_date': '2016-06-24'}