Title: Intracellular Localization of Carcinogen and its Relationship to the Mechanism of Carcinogenesis in Rat Liver
Abstract: THE experimental study of carcinogenesis aims at the finding of the common denominator for metabolic and structural changes which are characteristic of malignant transformation.In the previous paper (Fiala and Fiala, 1959) we tried to throw some light on this problem by correlating in time various changes during the carcinogenic process induced in rat liver by 3'-methyl, 4-dimethylaminoazobenzene. It was found that the whole process consists of two distinct * N = nucleus.M = mitochondria.CH = "fluffy layer ".R ergastoplasm.S soluble fraction.